1,246,504 results match your criteria Multiple Myeloma
Aktuelle Urol 2018 Dec 6;49(6):500-508. Epub 2018 Dec 6.
Klinik und Poliklinik für Urologie und Kinderurologie der Universitätsmedizin Mainz, Mainz.
Introduction: Virtual reality (VR) is an artificially simulated environment permitting interaction. On the other hand, augmented reality (AR) is an enhanced version of reality created by the use of technology to overlay digital information on an image of something being viewed through a device. Both technologies have partially been implemented in clinical daily routine. Read More
Cell Physiol Biochem 2018 Dec 6;51(5):2098-2110. Epub 2018 Dec 6.
Background/aims: Bortezomib (BTZ) is largely used as a chemotherapeutic agent for the treatment of multiple myeloma. However, one of the significant limiting complications of BTZ is painful peripheral neuropathy during BTZ therapy. The purpose of this study was to examine the underlying mechanisms leading to neuropathic pain induced by BTZ. Read More
Blood Purif 2018 Dec 6:1-7. Epub 2018 Dec 6.
Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Vicenza, Italy.
Background: Sepsis is a life-threatening condition often associated with a high incidence of multiple organs injury. Several papers suggested the immune response by itself, with the production of humoral inflammatory mediators, is crucial in determining organ injury. However, little is known of how sepsis directly induces organ injury at the cellular levels. Read More
J Environ Manage 2018 Dec 3;232:636-653. Epub 2018 Dec 3.
Institute for Water Quality and Resource Management, TU Wien, Karlsplatz 13/226, 1040, Vienna, Austria.
Occurrence and concentration of a broad spectrum of micropollutants are investigated in Austrian river catchments, namely polycyclic aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs), organotin compounds, perfluoroalkyl acids (PFAAs) and metals. The parallel analysis across multiple environmental and engineered compartments sheds light on the ratio of dissolved and particulate transport and on differences in concentration levels between point and diffuse emission pathways. It is found that some PAHs and organotins are present in rivers, groundwater and bulk deposition at higher concentrations than in municipal wastewater effluents. Read More
Epilepsy Behav 2018 Dec 3;90:99-106. Epub 2018 Dec 3.
Population, Policy and Practice Unit, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Background: Sudden Unexpected Death in Epilepsy (SUDEP) is a significant cause of death in childhood epilepsy, and causes considerable concern to patients and their families. Despite this, the condition remains poorly understood. This systematic review investigates the risk factors, pathophysiology, and circumstances associated with childhood SUDEP. Read More
Arch Oral Biol 2018 Nov 22;98:226-237. Epub 2018 Nov 22.
Ohio University Heritage College of Osteopathic Medicine, Department of Biomedical Sciences, Irvine Hall 228, Athens, OH, 45701, USA. Electronic address:
Objective: This study evaluates the effect of unilateral lingual sensory loss on the spatial and temporal dynamics of jaw movements during pig chewing.
Design: X-ray Reconstruction of Moving Morphology (XROMM) was used to reconstruct the 3-dimensional jaw movements of 6 pigs during chewing before and after complete unilateral lingual nerve transection. The effect of the transection were evaluated at the temporal and spatial level using Multiple Analysis of Variance. Read More
Sci Total Environ 2018 Nov 22;656:482-494. Epub 2018 Nov 22.
Nelson Mandela University, PO Box 77000, Port Elizabeth 6031, South Africa. Electronic address:
This paper presents an environmental flow methodology that was developed to accommodate shallow, highly dynamic micro-tidal estuaries found along the wave-dominated coast of South Arica. This method differs to most other approaches that primarily focus on larger permanently open systems having unrestricted inlets. Following an adaptive, design science research approach, the 7-step method adopted both ecohydrological and ecosystem-based concepts, encapsulating key hydrologicalhydrodynamic-biogeochemical processes, as well as biotic responses. Read More
Sci Total Environ 2018 Nov 23;656:458-467. Epub 2018 Nov 23.
Department of Hydrology, Faculty of Geography and Regional Studies, University of Warsaw, Krakowskie Przedmieście 30, 00-927 Warsaw, Poland. Electronic address:
Considering the growing recognition that human activity and climate variability are critical stressors influencing river regimes, there is an urgent need to identify the contribution of these fundamental factors. Here we examine the runoff changes of a wastewater-effluent dominated river flowing in a heavily modified urban environment. The study concerns the Utrata River basin (727 km), central Poland, a challenging human-natural system for investigating changes in hydrological processes. Read More
Clin Neurophysiol 2018 Nov 26;130(1):111-121. Epub 2018 Nov 26.
Department of Linguistics and Languages, McMaster University, Togo Salmon Hall 513, 1280 Main Street, West Hamilton, ON L8S 4M2, Canada; ARiEAL Research Centre, McMaster University, L.R. Wilson Hall, 1280 Main Street, West Hamilton, ON L8S 4M2, Canada; School of Biomedical Engineering, McMaster University, ETB-406, 1280 Main St., West Hamilton, ON L8S 4K1, Canada; MaRS Centre, Vector Institute, Canada; McMaster University, Department of Psychology, Neuroscience and Behaviour, Canada. Electronic address:
Objective: Recent studies demonstrate that sports-related concussions can have negative consequences on long-term brain health. The goal of the present study was to determine whether retired Canadian Football League (CFL) athletes with a history of concussions exhibit alterations in neurocognitive functioning, along with changes in physical, social, and psychological health.
Methods: Our study compared nineteen retired CFL athletes' concussion histories to eighteen healthy age-matched controls with no history of concussion. Read More
J Psychiatr Res 2018 Nov 27;109:107-117. Epub 2018 Nov 27.
Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, CEP 97105-900, Santa Maria, Rio Grande do Sul, Brazil. Electronic address:
Alzheimer 's disease (AD) is characterized by progressive cognitive decline including memory impairment, cortical dysfunction, and neuropsychiatric disturbances. The drug discovery to treat AD consists to develop compounds able to act in multiple molecular targets involved in the pathogenesis of the disease and the repositioning of old drugs for new application. This way, the intracerebroventricular (icv) injection of streptozotocin (STZ) has been used as a metabolic model of sporadic AD. Read More
J Inorg Biochem 2018 Nov 28;191:135-142. Epub 2018 Nov 28.
Institute of Environmental Toxicology and Environmental Ecology, Yancheng Teachers University, Yancheng City, Jiangsu Province 224007, People's Republic of China. Electronic address:
In this work, we designed polysaccharide-metal complex of dopamine-modified pectin linking ruthenium compound, which exhibited a certain inhibition specificity to human renal cell adenocarcinoma cell line 786-O. The chemical structure and physical properties of the polysaccharide-metal complex were well characterized by multiple analysis methods. The multi-spectral results revealed that pectin-dopamine have been successfully coordinated by ruthenium complex to form nano-conjugates, which self-assembled into relatively regular nanospheres of approximately 200 nm. Read More
Drug Discov Today 2018 Dec 3. Epub 2018 Dec 3.
Pfizer, Pfizer Essential Health, US Medical Affairs Women's s Health. Electronic address:
Technical expertise and a spirit of inquiry serve as cornerstones for a career in science. Within that career, there are multiple pathways across disciplines, therapeutic areas, and sectors. To optimize career planning, I showcase here a career development framework that integrates four pillars: behavior, experience, skill, and training (BEST). Read More
Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.
Department of Medical Oncology, CAncer Research for PErsonalized Medicine (CARPEM), Paris Centre Teaching Hospitals, Paris Descartes University, USPC, Paris, France.
Body composition has gained increasing attention in oncology in recent years due to fact that sarcopenia has been revealed to be a strong prognostic indicator for survival across multiple stages and cancer types and a predictive factor for toxicity and surgery complications. Accumulating evidence over the last decade has unraveled the "pharmacology" of sarcopenia. Lean body mass may be more relevant to define drug dosing than the "classical" body surface area or flat-fixed dosing in patients with cancer. Read More
Biotechnol Adv 2018 Dec 3. Epub 2018 Dec 3.
Department of Molecular Sciences, Macquarie University, Sydney, Australia; Biomolecular Discovery and Design Research Centre, Macquarie University, Sydney, Australia. Electronic address:
Single enzyme systems or engineered microbial hosts have been used for decades but the notion of assembling multiple enzymes into cell-free synthetic pathways is a relatively new development. The extensive possibilities that stem from this synthetic concept makes it a fast growing and potentially high impact field for biomanufacturing fine and platform chemicals, pharmaceuticals and biofuels. However, the translation of individual single enzymatic reactions into cell-free multi-enzyme pathways is not trivial. Read More
J Invest Dermatol 2018 Dec 3. Epub 2018 Dec 3.
Department of Paediatrics, Prince of Wales Hospital, Hong Kong, SAR China.
Some previously described environmental associations for atopic eczema (AE) may be due to reverse causation. We explored the role of reverse causation by comparing individual- and school-level results for multiple AE risk factors. ISAAC Phase Three surveyed children within schools (the sampling unit) on AE symptoms and potential risk factors. Read More
Antiviral Res 2018 Dec 3. Epub 2018 Dec 3.
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Arboviruses represent a group of pathogens that can spread efficiently throughout human populations by hematophagous arthropod vectors. The mosquito-borne (re)emerging Chikungunya and Dengue viruses belong to the alphavirus and flavivirus genus, respectively, with no approved therapeutics or safe vaccines for humans. Transmitted by the same vector Aedes spp. Read More
J Control Release 2018 Dec 3. Epub 2018 Dec 3.
Department of Cardiac Surgery, First Affiliated Hospital, China Medical University, Shenyang, PR China. Electronic address:
Coronary artery bypass graft surgery (CABG) is an effective therapeutic method for coronary artery disease. Great saphenous vein is the predominant graft due to the accessibility, sufficient length and suitable size matching with coronary artery. However, saphenous vein graft failure (SVGF) always restrict the long-term success of CABG. Read More
J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.
Loyola University Medical Center Dermatology, 321 N La Grange Rd, La Grange Park, IL. Electronic address:
•Hematologic malignancies have been reported sporadically in patients with pemphigus.•In the current study, significant associations were observed between pemphigus and chronic leukemia, multiple myeloma, and non-Hodgkin lymphoma.•Further research is needed to confirm these findings in other cohorts. Read More
Surv Ophthalmol 2018 Dec 3. Epub 2018 Dec 3.
Associate Professor, Departments of Clinical Neurosciences and Surgery, University of Calgary.
A 45-year-old Caucasian woman presented with chronic bilateral, painless, progressive, peripheral vision loss. She was found to have bilateral optic atrophy and non-enhancing multifocal white matter lesions on magnetic resonance imaging of the brain. Cerebrospinal fluid analysis showed elevated myelin basic protein. Read More
Dev Biol 2018 Dec 3. Epub 2018 Dec 3.
Division of Ecology and Evolution, Bldg 46, Research School of Biology, Australian National University, Canberra, ACT 0200, Australia; ARC Centre of Excellence for Coral Reef Studies, James Cook University, Townsville, QLD 4811, Australia. Electronic address:
Neuropeptides play critical roles in cnidarian development. However, although they are known to play key roles in settlement and metamorphosis, their temporal and spatial developmental expression has not previously been characterized in any coral. We here describe Acropora millepora LWamide and RFamide and their developmental expression from the time of their first appearance, using in situ hybridization and FMRFamide immunohistochemistry. Read More
ACS Nano 2018 Dec 6. Epub 2018 Dec 6.
Understanding the molecular-level properties of electrochemically-active ions at operating electrode-electrolyte interfaces (EEI) is key to the rational development of high-performance nanostructured surfaces for applications in energy technology. Herein, an electrochemical cell coupled with ion soft landing is employed to examine the effect of "atom-by-atom" metal substitution on the activity and stability of well-defined redox-active anions, PMoWO (x = 0,1,2,3,6,9,12), at nanostructured ionic liquid EEI. A striking observation made by in situ electrochemical measurements and further supported by theoretical calculations is that substitution of only (1-3) tungsten by molybdenum atoms in the PWO anions results in a substantial spike in their first reduction potential. Read More
Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):364-370. Epub 2018 Nov 30.
Secretaría de Salud, Hospital General de México “Dr. Eduardo Liceaga”, Unidad de Neumología y Cirugía de Tórax. Ciudad de México, México
Background: Tuberculosis is a public health problem, extrapulmonary presentations have increased, it is difficult to diagnose because of the low bacillary load.
Objective: To identify risk factors and to evaluate the efficiency of diagnostic methods in pleural, meningeal, peritoneal and pericardial tuberculosis.
Methods: Prospective study of cases and controls. Read More
Acta Ortop Mex 2018 May-Jun;32(3):140-144
Módulo de Cirugía de Hombro y Codo, Hospital General Xoco. Av. México Coyoacán S/N, Col. General Anaya, Deleg. Benito Juárez, CP 03340, Ciudad de México, México.
Background: Fractures of the lateral third of the clavicle represent 18% of all clavicle fractures. Even though non-displaced fractures can be managed conservatively, displaced fractures have a non-union percentage of 30%. Multiple approaches have been proposed to manage the displaced fractures. Read More
PLoS One 2018 6;13(12):e0208551. Epub 2018 Dec 6.
Key Laboratory of Ministry of Education for Genetics, Breeding and Multiple Utilization of Crops, College of Crop Science, Fujian Agriculture and Forestry University, Fuzhou, P.R. China.
Inbred lines are important germplasm in cauliflower breeding programs. To understand the genetic diversity and relationships of cauliflower inbred lines, the use of simple sequence repeat (SSR) markers will be of great value for parental line selection and breeding strategy design. In this study, the genetic diversity and relationships of 165 cauliflower inbred lines primarily derived from southeast China were assessed using SSR markers. Read More
PLoS One 2018 6;13(12):e0208494. Epub 2018 Dec 6.
School of Computer and Information Technology, Shanxi University, Taiyuan, China.
Since multi-view data are available in many real-world clustering problems, multi-view clustering has received considerable attention in recent years. Most existing multi-view clustering methods learn consensus clustering results but do not make full use of the distinct knowledge in each view so that they cannot well guarantee the complementarity across different views. In this paper, we propose a Distinction based Consensus Spectral Clustering (DCSC), which not only learns a consensus result of clustering, but also explicitly captures the distinct variance of each view. Read More
PLoS One 2018 6;13(12):e0208435. Epub 2018 Dec 6.
Occupational and environmental medicine, Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Recurrent headache, abdominal and musculoskeletal pain are common in adolescents and it is therefore important to understand their impact on the transitional period from childhood to adulthood. However, studies of the prevalence over time and implications on educational outcomes are still limited, especially regarding multiple pain symptoms. The present study material consists of questionnaire surveys, completed in 2000 and 2008, including two study populations of 9th grade adolescents aged 15 living in West Sweden (n = 20 877). Read More
PLoS One 2018 6;13(12):e0208403. Epub 2018 Dec 6.
University of Portsmouth, Department of Psychology, Portsmouth, United Kingdom.
Research in perception and recognition demonstrates that a current decision (i) can be influenced by previous ones (i-j), meaning that subsequent responses are not always independent. Experiments 1 and 2 tested whether initial showup identification decisions impact choosing behavior for subsequent showup identification responses. Participants watched a mock crime film involving three perpetrators and later made three showup identification decisions, one showup for each perpetrator. Read More
PLoS One 2018 6;13(12):e0207459. Epub 2018 Dec 6.
De la Préhistoire à l'Actuel, Culture, Environnement, Anthropologie-UMR 5199, CNRS, Université de Bordeaux, Allée Geoffroy Saint-Hilaire, CS, Pessac Cedex, France.
The compilation of archaeological and genetic data for ancient European human groups has provided persuasive evidence for a complex series of migrations, population replacements and admixture until the Bronze Age. If the Bronze-to-Iron Age transition has been well documented archaeologically, ancient DNA (aDNA) remains rare for the latter period and does not precisely reflect the genetic diversity of European Celtic groups. In order to document the evolution of European communities, we analysed 45 individuals from the Late Iron Age (La Tène) Urville-Nacqueville necropolis in northwestern France, a region recognized as a major cultural contact zone between groups from both sides of the Channel. Read More
PLoS One 2018 6;13(12):e0208251. Epub 2018 Dec 6.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
Background: Numerous clinical practice guidelines (CPGs) are published to guide management of osteoporosis. Little is known about their quality or how recommendations have changed over time.
Objective: To systematically assess the quality and content of the guidelines on screening for osteoporosis, using the Appraisal of Guidelines for Research and Evaluation (AGREE II) tool, and the Institute of Medicine (IOM) standards for trustworthy guidelines. Read More
PLoS One 2018 6;13(12):e0207843. Epub 2018 Dec 6.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.
Aims: To investigate associations of glomerular hyperfiltration with other metabolic factors in a nationally representative dataset.
Methods: We analyzed cross-sectional data from 15,918 subjects with estimated glomerular filtration rate (eGFR) >60 ml/min/1.73 m2 and urine albumin creation ratio (ACR) <30 mg/g, who participated in the 5th and 6th Korea National Health and Nutrition Examination Surveys. Read More
PLoS One 2018 6;13(12):e0206053. Epub 2018 Dec 6.
Department of Gynecological Endocrinology and Fertility Disorders, University of Heidelberg, Heidelberg, Germany.
Background: Local anesthetics (LAs) are increasingly used as therapeutics due to their multiple molecular effects. They may be potential agents also in gynecology and reproductive medicine. The objective of this study was to investigate the contractility response of the perfused swine uterus to different concentrations of the LAs procaine, lidocaine, and ropivacaine. Read More
PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006888. Epub 2018 Dec 6.
Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Background: Despite the overall decrease in visceral leishmaniasis (VL) incidence on the Indian subcontinent, there remain spatiotemporal clusters or 'hotspots' of new cases. The characteristics of these hotspots, underlying transmission dynamics, and their importance for shaping control strategies are not yet fully understood and are investigated in this study for a VL endemic area of ~100,000 inhabitants in Bihar, India between 2007-2015.
Methodology/principal Findings: VL incidence (cases/10,000/year) dropped from 12. Read More
PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006935. Epub 2018 Dec 6.
Draper, Cambridge, Massachusetts, United States of America.
Background: Rainfall patterns are one of the main drivers of dengue transmission as mosquitoes require standing water to reproduce. However, excess rainfall can be disruptive to the Aedes reproductive cycle by "flushing out" aquatic stages from breeding sites. We developed models to predict the occurrence of such "flushing" events from rainfall data and to evaluate the effect of flushing on dengue outbreak risk in Singapore between 2000 and 2016. Read More
Nanotechnology 2019 Feb;30(5):055301
Department of Physics and London Centre for Nanotechnology, King's College London, Strand, London, WC2R 2LS, United Kingdom.
Metamaterials and metasurfaces provide unprecedented opportunities for designing light-matter interactions. Optical properties of hyperbolic metamaterials with meta-atoms based on plasmonic nanorods, important in nonlinear optics, sensing and spontaneous emission control, can be tuned by varying geometrical sizes and arrangement of the meta-atoms. At the same time the role of the shape of the meta-atoms forming the array has not been studied. Read More
Rom J Intern Med 2018 Dec;56(4):233-242
Laboratory of Allergology and Clinical Immunology, "Nicolae Testemitanu" State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.
Pancreas divisum (PD) is the most common developmental anatomic variant of pancreatic duct. The attention towards the PD has grown significantly since there are reports that this condition may cause acute relapsing pancreatitis, chronic pancreatitis and chronic abdominal pain syndrome. Furthermore, over the years, there have been multiple reports of PD associated with different types of tumors. Read More
Rom J Intern Med 2018 Dec;56(4):265-268
National Institute of Neurology and Neurovascular Diseases, Bucharest, Romania.
Acute promyelocytic leukemia often manifests with hemorrhagic diathesis, thrombotic events being much rarer. This is the case of a 59-year-old patient with thrombotic cerebro-vascular complications as the onset manifestation of acute promyelocytic leukemia. Read More
Multivariate Behav Res 2018 Dec 6:1-16. Epub 2018 Dec 6.
a Department of Educational Policy Studies , Georgia State University.
While conventional hierarchical linear modeling is applicable to purely hierarchical data, a multiple membership random effects model (MMrem) is appropriate for nonpurely nested data wherein some lower-level units manifest mobility across higher-level units. Although a few recent studies have investigated the influence of cluster-level residual nonnormality on hierarchical linear modeling estimation for purely hierarchical data, no research has examined the statistical performance of an MMrem given residual non-normality. The purpose of the present study was to extend prior research on the influence of residual non-normality from purely nested data structures to multiple membership data structures. Read More
Aging Ment Health 2018 Dec 6:1-9. Epub 2018 Dec 6.
b Faculty of Health Sciences , Western University , London , Canada.
Objectives: The study used data from the Canadian Longitudinal Study on Aging to investigate the relationships among social support (measured as affectionate support, emotional/informational support, positive social interaction, tangible support), social participation and depression in caregivers and non-caregivers.
Method: Hierarchical multiple regression was used to investigate relationships among social support, social participation, and depression. Analyses of variance were used to examine differences in the means of social support, social participation, and depression between the two participant groups. Read More
Appl Physiol Nutr Metab 2018 Dec 6. Epub 2018 Dec 6.
University of Miami, Kinesiology and Sport Sciences, Coral Gable, Florida, United States ;
The presence of postganglionic sympathetic denervation is well established in Parkinson's disease (PD). Denervation at cardiac and blood vessel sites may lead to abnormal cardiovascular and hemodynamic responses to exercise. The aim of the present investigation was to examine how heart rate (HR) and hemodynamics are affected by an exercise test in PD patients without orthostatic hypotension. Read More
J Agric Food Chem 2018 Dec 6. Epub 2018 Dec 6.
Food and feed safety assessment is not enhanced by performing protein expression analysis on stacked trait products. The expression levels of six proteins in cotton matrices from four single cotton events and three conventionally stacked trait cotton products are reported. Three proteins were for insect control, two proteins confer herbicide tolerance, and one protein was a transformation selectable marker. Read More