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J Osteopath Med 2021 May 7. Epub 2021 May 7.

Department of Pediatrics, Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA.

Context: Asthma is a leading cause of pediatric chronic illness, and poor disease control can lead to decreased quality of life and impaired academic performance. Although osteopathic manipulative treatment (OMT) has been shown to have positive effects on pulmonary function in adult patient populations, less is known about its impact in children.

Objectives: To evaluate changes in pulmonary function testing (PFT) in pediatric patients on the same day they received OMT compared with PFT in those who received usual care. Read More

J Perinat Med 2021 May 6. Epub 2021 May 6.

Department of Obstetrics and Gynecology, Women's Wellness and Research Centre, Hamad Medical Corporation, Doha, Qatar.

Objectives: To examine the impact of early term caesarean section (CS) on respiratory morbidity and early neonatal outcomes when elective caesarean section was carried out before 39 completed weeks gestation in our population.

Methods: A one-year population-based retrospective cohort analysis using routinely collected hospital data. Livebirths from women who had elective lower segment cesarean section (ELSCS) for uncomplicated singleton pregnancies at early term (ET) 37+0 to 38+6 weeks were compared to full term (FT)≥39+0 weeks gestation. Read More

J Complement Integr Med 2021 May 7. Epub 2021 May 7.

Neurophysiology Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.

Objectives: Dopamine neurotransmission is implicated in multiple neuropsychiatric disorders, most strikingly in Parkinson's disease, bipolar disorder, attention-deficit hyperactivity disorder and schizophrenia. In addition to canonical pathway, D2-receptor (D2R) exerts some of its biological actions through regulating the activity of Akt and GSK3, which in turn were found to be altered in several psychiatric illnesses. The present study examined the impacts of maternal separation, an early-life stress model which has been associated with disturbed neurodevelopment and appearance of many psychiatric disorders, on developmental changes in dopamine concentration and the expression of D2Rs, Akt and GSK-3β in the medial prefrontal cortex (PFC; a key target of stress) in adolescent and young adult male rats. Read More

Immunohematology 2021 Mar;37(1):13-17

Department of Transfusion Medicine and Transplantation Biology, University Clinical Hospital Zagreb , Zagreb , Croatia .

Many patients with anti-Yt receive multiple transfusions of Yt(a+) red blood cells (RBCs) with no ill effects. However, anti-Yt has been implicated in hemolytic transfusion reactions. Antibody identification typically determines specificity of antibodies and their clinical significance to justify blood requirements for antigen-negative blood when clinically significant antibodies are involved. Read More

Horm Metab Res 2021 May 7;53(5):285-292. Epub 2021 May 7.

Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal.

Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy. For stage I and II tumors, surgery is a curative option, but even in these cases recurrence is frequent. Practical guidelines advocate a combination of mitotane with etoposide, doxorubicin, and cisplatin as first-line therapy for metastatic adrenocortical carcinoma. Read More

J Neurosurg 2021 May 7:1-8. Epub 2021 May 7.

Departments of1Neurological Surgery.

Objective: Silent corticotroph adenomas (SCAs) are a distinct subtype of nonfunctioning pituitary adenomas (NFAs) that demonstrate positive immunohistochemistry for adrenocorticotropic hormone (ACTH) without causing Cushing's disease. SCAs are hypothesized to exhibit more aggressive behavior than standard NFAs. The authors analyzed their institution's surgical experience with SCAs in an effort to characterize rates of invasion, postoperative clinical outcomes, and patterns of disease recurrence and progression. Read More

J Affect Disord 2021 Mar 5;289:90-97. Epub 2021 Mar 5.

University of Texas at Austin.

Although depression symptoms are often treated as interchangeable, some symptoms may relate to adolescent life satisfaction more strongly than others. To assess this premise, we first conducted a network analysis on the Mood and Feelings Questionnaire (MFQ) in a large (N = 1,059), cross-sectional sample of community adolescents (age M = 14.72 ± 1. Read More

Early Hum Dev 2021 Apr 29;157:105379. Epub 2021 Apr 29.

Department of Neonatal Medicine, Osaka Women's and Children's Hospital, 840 Murodo-cho, Izumi, Osaka 594-1101, Japan. Electronic address:

Background: Skin-to-skin care (SSC) reduces neonatal mortality and morbidity and is widely implemented in the neonatal intensive care unit. However, changes in respiratory effort during SSC in ventilated preterm infants remain unclear.

Aims: To evaluate the effect of SSC on electrical activity of the diaphragm (Edi) and vital signs in premature infants who are intubated and under neurally adjusted ventilatory assist ventilation. Read More

Early Hum Dev 2021 May 4;157:105381. Epub 2021 May 4.

Department of Medical Psychology, Leiden University Medical Center, the Netherlands.

Aim: To investigate the school performance and behavioral difficulties in children with hemolytic disease of the fetus and newborn (HDFN) treated with intrauterine transfusion (IUT) compared to Dutch norm data.

Study Design: Cros-sectional cohort study.

Subjects: Children who received one or multiple IUTs for severe Rh- or K (Kell)-mediated HDFN between January 2008 and January 2015 at the LUMC. Read More

Eur J Cancer 2021 May 4;151:35-48. Epub 2021 May 4.

Department of Urology, Medical University of Vienna, Vienna, Austria; Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia; Research Division of Urology, Department of Special Surgery, The University of Jordan, Amman, Jordan; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Urology, Weill Cornell Medical College, New York, NY, USA; Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria; European Association of Urology Research Foundation, Arnhem, Netherlands. Electronic address:

Introduction: Platinum-based combination chemotherapy is the standard treatment for patients with chemotherapy-eligible metastatic urothelial carcinoma (mUC). Immune-checkpoint inhibitors (ICIs) are currently assessed in this setting. This review aimed to assess the role of ICIs alone or in combination as first-line treatment in chemotherapy-eligible patients with mUC. Read More

Psychiatry Res 2021 Apr 22;301:113955. Epub 2021 Apr 22.

Center for Mental Health Education, Faculty of Psychology, Southwest University, Chongqing, China. Electronic address:

This study sought to identify the developmental trajectories of depressive symptoms and delinquency in Chinese left-behind children (LBC) over a three-year period, a topic that is less often studied. Overall, 578 Chinese LBC (M= 10.63 years; boys = 53. Read More

Psychiatry Res 2021 Apr 21;301:113956. Epub 2021 Apr 21.

Brown School of Social Work, Washington University in St. Louis, Goldfarb Hall, Room 358, Campus Box 1196, One Brookings Drive, St. Louis, MO 63130, United States.

Cognitive remediation (CR) is an evidence-based therapy used to improve cognition in people with schizophrenia. However, it often requires multiple in-person clinic sessions per week, which can limit scalability. This mixed methods study considered the feasibility and acceptability of a hybrid approach, which allowed for half the sessions to be conducted remotely as homework, without the clinician present. Read More

Pediatr Neurol 2021 Apr 2;120:7-10. Epub 2021 Apr 2.

Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Background: Tuberous sclerosis complex (TSC) is a genetic disorder that is manifested in multiple body systems. A mammalian target of rapamycin (mTOR) inhibitor (mTORi), either everolimus or sirolimus, is now routinely prescribed for multiple clinical manifestations of TSC, including subependymal giant cell astrocytoma and epilepsy. These medications are generally well tolerated. Read More

J Clin Anesth 2021 May 5;73:110331. Epub 2021 May 5.

Zucker School of Medicine at Hofstra/Northwell, Department of Anesthesiology, Northwell Health, New Hyde Park, NY, United States of America.

Study Objective: To identify whether adding intrathecal ketamine to intrathecal bupivacaine prolongs the time to first analgesic request in adult humans.

Design: A meta-analysis of randomized controlled trials in humans.

Setting: The majority of data was obtained in an operating room and postoperative recovery area. Read More

J Neurol Sci 2021 Apr 29;426:117472. Epub 2021 Apr 29.

Department of Neurology, Kitasato University School of Medicine, Sagamihara, Japan.

Background: Asymptomatic acute ischemic lesions (AIL) may be coincidentally found on brain magnetic resonance imaging (MRI) obtained during the acute phase of intracerebral hemorrhage, but its clinical significance has yet to be determined. The objective of this study is to determine the frequency of asymptomatic AIL, its characteristic features of brain MRI and risk factors in patients with acute intracerebral hemorrhage.

Methods: We retrospectively reviewed the clinical information of 108 patients with intracerebral hemorrhage who underwent brain MRIs within 30 days of hospitalization between April 2013 and January 2018. Read More

Microbiol Res 2021 Apr 29;249:126774. Epub 2021 Apr 29.

Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Sciences, Nanjing Normal University, Nanjing, China. Electronic address:

In agroecosystems, drought stress severely threatens crops development. Although potassium (K) is required in amounts by crops under drought stress, the mobilization and availablity of K are limited by the soil water status. Arbuscular mycorrhizal (AM) fungi can form mutualistic associations with most crops and play direct or indirect roles in the host drought resistance. Read More

Chemosphere 2021 Apr 19;280:130582. Epub 2021 Apr 19.

Aarhus University, Department of Environmental Science, Environmental Metabolomics Lab, Roskilde, Denmark. Electronic address:

Amendment of soil with organic urban and animal wastes can keep arable soil fertile without the need for synthetic fertilizers. However, pollutants present in these types of waste might be carried into the soil with unintended consequences for the environment. We studied an experimental agricultural plot, which had been amended with either synthetic inorganic fertilizers, human urine, manure, or wastewater treatment sludge at very high rates. Read More

J Environ Manage 2021 May 4;291:112675. Epub 2021 May 4.

Universidad Nacional de Colombia - Sede Medellín, Facultad de Minas, Departamento de Ciencias de la decisión y la computación, Cra 80 No 65-223, Bloque M8, Colombia. Electronic address:

The high dependence of human communities on ecosystems' well-functioning has transformed and degraded ecosystems at alarming rates. Strategies for sustainability are an urgent need and requires the understanding of the complex interactions between human and ecological systems in the territories. For such understanding several modelling approaches have been proposed, but still face important challenges. Read More

J Environ Manage 2021 May 4;291:112638. Epub 2021 May 4.

Conservation Science Research Group, School of Environmental and Life Sciences, Biology Building, University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia.

Amphibians have declined due to multiple impacts including invasive fish and the disease chytridiomycosis caused by the chytrid fungus Batrachochytrium dendrobatidis (Bd). Wetland restoration can be used to increase amphibian populations. However the design of created wetlands must account for threats such as Bd and introduced fish. Read More

Int J Surg Case Rep 2021 Apr 27;82:105905. Epub 2021 Apr 27.

Department of General Surgery, Al-Hada Armed Forces Hospital, Taif, Saudi Arabia.

Introduction And Importance: Heterotopic mesenteric ossification is a benign bony tissue growth in the mesentery that mostly follows repetitive or severe abdominal injuries leading to reactive bone formation in the mesentery. There are only 73 cases (51 publications) identified in the literature up to the beginning of 2020.

Case Presentation: 45-year-old Saudi male underwent multiple laparotomies to manage complicated appendicitis which ended with a diverting ileostomy and a colostomy as a mucus fistula. Read More

Int J Surg Case Rep 2021 Apr 27;82:105900. Epub 2021 Apr 27.

Kscien Organization, Hamdi Str, Azadi Mall, Sulaimani, Kurdistan, Iraq; Department of Medical Analysis, Tishk International University, Erbil, Kurdistan Region, Iraq.

Introduction And Importance: Lymph node metastasis is the most prominent prognostic factor in breast cancer. The aim of this paper is to report a case of contralateral axillary lymph node metastasis (CAM) which look like metachronous initially, but histopathologicaly confirmed as synchronous CAM.

Case Presentation: A-44-year old female was a known case of left breast cancer five years prior to this presentation (T2,N2,M0, grade III, Triple negative, multifocal invasive ductal carcinoma). Read More

Epilepsy Behav 2021 May 4;120:107992. Epub 2021 May 4.

Department of Psychiatry and Behavioral Neurosciences, McMaster University/St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.

Objective: Parent caregivers often play vital roles in the care of adolescents with epilepsy (AWE) in resource-restricted settings; however, little is known about the burden borne by these parents. This study investigated the burden perceived by parents of AWE and described the explanatory factors.

Methods: An equal number (n = 121) of age- and gender-matched parent caregivers of AWE (cases) and parents of adolescents with sickle cell disease (comparison group) were interviewed with the Parent Illness Intrusiveness Rating Scale to assess disruptions in their relationships and lifestyle. Read More

Epilepsy Behav 2021 May 4;120:107979. Epub 2021 May 4.

Department of Epileptology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: Acceptance of disability (AOD) is a key concept in rehabilitation psychology that enhances psychosocial adjustment of individuals with disability. However, the impact of AOD on well-being has never been examined for patients with epilepsy. The present study investigated whether AOD affects quality of life (QOL) in patients with epilepsy in the presence of other multiple aspects of epilepsy based on the biopsychosocial model. Read More

Cancer Treat Res Commun 2021 Apr 25;28:100380. Epub 2021 Apr 25.

Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Multiple myeloma (MM), is a heterogeneous disease in which chromosomal abnormalities are important for prognostic risk stratification. Cytogenetic profiling with FISH on plasma cells from bone marrow samples (BM-PCs) is the current gold standard, but variable infiltration of plasma cells or failed aspiration can hamper this process. Ultra-low coverage sequencing (ULCS) of circulating cell-free DNA (ccfDNA) may offer a minimally invasive alternative for the work-up of these cases. Read More

Biochem Biophys Res Commun 2021 May 4;559:230-237. Epub 2021 May 4.

National Centre for Cell Science, S.P. Pune University Campus, Pune, 411007, India. Electronic address:

MicroRNA (miRNA)-mediated translational suppression of mRNAs is involved in the regulation of multiple cellular processes. A recent study showed that Nup358, a protein mutated in a neurological disorder called acute necrotizing encephalopathy 1 (ANE1), helps in the coupling of miRNA-induced silencing complex (miRISC) - consisting of miRNA, AGO and GW182/TNRC6 proteins - with the target mRNA. Here we provide a detailed characterization of the interaction between Nup358 and GW182. Read More

Biochem Biophys Res Commun 2021 May 4;559:222-229. Epub 2021 May 4.

Key Laboratory of Traditional Chinese Medicine Analysis, School of Pharmaceutical Sciences, Changchun University of Traditional Chinese Medicine, Changchun, 130117, China. Electronic address:

As one of the natural triterpenoids isolated from Anemone Raddeana Regel, Raddeanin A (RA) has been confirmed to possess therapeutic effects against multiple tumorigeneses, especially for the onset of glioblastoma and growth in human brains. However, the mechanism by which this happens remains poorly understood in terms of the vascular endothelium trafficking routine of RA through the brain-blood barrier (BBB). To seek such answers, human brain microenvironment endothelial cells (HBMECs) were used to stimulate the microenvironment in vitro, and to explore the intracellular accumulation of RA. Read More

Food Chem 2021 Apr 20;359:129820. Epub 2021 Apr 20.

STLO, Agrocampus Ouest, UMR1253, INRAE, 35000 Rennes, France.

Caseins are recognized as safe for consumption, abundant, renewable and have high nutritional value. Casein molecules are found in different aggregation states and their multiple binding sites offer the potential for delivering biomolecules with nutritional and/or health benefits, such as vitamins, phytochemicals, fibers, lipids, minerals, proteins, peptides, and pharmaceutical compounds. In the present review, we highlight the interactions between caseins and food-derived bioactive molecules, with a special focus on the aggregation states of caseins and the techniques used to produce and study the particles used for delivering. Read More

Clin Imaging 2021 Mar 31;78:187-193. Epub 2021 Mar 31.

Department of Radiology, Longyan First Hospital, Fujian Medical University, No. 105 North 91 Road, Xinluo District, Fujian 364000, China.

Objective: A recent study described the relationship between cerebral venous diameter and white matter hyperintensity (WMH) volume. However, the adults were not further grouped; therefore, we aimed to compare across age groups and use susceptibility-weighted imaging (SWI) to explore whether there is also a relationship between a larger cerebral draining venous diameter and age, which could provide evidence of a temporal relationship.

Methods: We retrospectively analysed data collected from 405 subjects (90 youths, 166 middle-aged participants, and 149 elderly subjects) and respectively used T2-weighted fluid-attenuated inversion recovery (FLAIR) and SWI to assess WMHs and venous diameter. Read More

J Pharm Biomed Anal 2021 Apr 29;201:114108. Epub 2021 Apr 29.

Department of Pharmaceutics, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh, 11451, Saudi Arabia.

A novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the rapid and sensitive enantioselective analysis of verapamil (VER) in rat plasma was developed and validated using new superficially porous silica isopropyl-cyclofructan 6 chiral column (LarihcShell-P, LSP). The isocratic mobile phase composed of acetonitrile: trifluoroacetic acid: 10 mM ammonium formate (100 : 0.1 : 0. Read More

J Neuroimmunol 2021 Apr 30;356:577589. Epub 2021 Apr 30.

Department of Neurology, Nitobe Memorial Nakano General Hospital, Japan; Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Japan. Electronic address: