70 results match your criteria Multinucleate Cell Angiohistiocytoma


Generalized Multinucleate Cell Angiohistiocytoma: Histopathological and Immunohistochemical Analyses of 10 Lesions.

Am J Dermatopathol 2021 Apr 21. Epub 2021 Apr 21.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University Hospital, Philadelphia, PA; and Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.

Abstract: Multinucleate cell angiohistiocytoma (MCAH) is an uncommon fibrohistiocytic disorder that usually presents as a localized solitary papule or multiple grouped papules. Generalized presentation is very rare with less than 20 cases reported in the literature. In this article, we present histopathological and immunohistochemical studies of 10 lesions from a patient with generalized MCAH. Read More

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Generalized multinucleate cell angiohistiocytoma with possible origin from fibroblasts: A clinicopathological study of 15 cases.

J Dermatol 2021 Jan 12;48(1):114-119. Epub 2020 Nov 12.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Multinucleate cell angiohistiocytoma (MCAH) is a vascular and fibrohistiocytic proliferation with unknown pathogenesis. Clinical lesions tend to be localized to an anatomical area. Exceptionally, the generalized variant is rare. Read More

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January 2021

Multinucleate cell angiohistiocytoma: an uncommon cutaneous tumor.

An Bras Dermatol 2020 Jul - Aug;95(4):480-483. Epub 2020 May 11.

Department of Dermatology, Faculdade de Medicina do ABC, Santo André, SP, Brazil.

Multinucleate cell angiohistiocytoma is a rare, benign vascular proliferation of unknown etiology. It occurs mainly in middle-aged women and usually affects the acral regions; the lesions appear as discrete, grouped, and asymptomatic violaceous papules. Histopathology shows proliferation and dilated small vessels in the papillary dermis, fibrous stroma with thickened collagen bundles, and multinucleated giant cells. Read More

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Fibroblastic Rheumatism Versus Variant Disease of Multinucleate Cell Angiohistiocytoma.

Am J Dermatopathol 2020 Feb;42(2):136-139

National Skin Centre, Singapore.

We report an unusual case of a 49-year-old woman who presented with persistent papulonodules over bilateral fingers and inframammary region in conjunction with features of connective tissue disease including symmetrical polyarthritis and Raynaud phenomenon. Skin biopsy showed an upper-to-mid dermal proliferation of bland spindled cells with thickened collagen bundles and occasional multinucleated giant cells. Dermal blood vessels were only marginally increased. Read More

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February 2020

Cutaneous plasmacytosis and multinucleate cell angiohistiocytoma-like lesion in a patient with hepatitis B: A fortuitous triad?

J Cutan Pathol 2019 Sep 28;46(9):678-683. Epub 2019 May 28.

Division of Pathology, University of Montréal, Montréal, Québec, Canada.

A 28-year-old woman of Chinese descent, with congenital chronic hepatitis B presented with a 7-year history of erythematous-brown papules and plaques on her groins, axillae, and forehead. A first skin biopsy showed findings consistent with two concomitant, yet highly uncommon cutaneous diseases. The presence of lymphoid nodules with germinal centers and clustered polyclonal plasma cells was consistent with cutaneous plasmocytosis. Read More

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September 2019

Successful treatment of multinucleate cell angiohistiocytoma with fractionated ablative CO laser.

JAAD Case Rep 2019 Apr 25;5(4):297-299. Epub 2019 Mar 25.

Department of Dermatology, Brown University, Providence, Rhode Island.

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Multinucleate cell angiohistiocytoma: A clinicopathologic study of 62 cases and proposed diagnostic criteria.

J Cutan Pathol 2019 Aug 23;46(8):563-569. Epub 2019 Apr 23.

Department of Dermatology, Yale University Medical School, New Haven, Connecticut.

Background: Multinucleate cell angiohistiocytoma (MCAH) is an uncommon and likely underdiagnosed entity that is thought to be of vascular and fibrohistiocytic origin.

Methods: We retrospectively reviewed all cases diagnosed as MCAH at the Yale Medicine Dermatopathology laboratory between 1 January 1990 and 1 September 2018. Sixty-two cases were retained. Read More

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A case of multinucleate cell angiohistiocytoma in a 14-year-old boy showing two different clinical and histopathological findings.

J Cutan Pathol 2019 Mar 26;46(3):221-225. Epub 2018 Dec 26.

Department of Dermatology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea.

Multinucleate cell angiohistiocytoma (MCAH) is a rare cutaneous disease entity characterized by multiple red-to-brown or violaceous papules usually located on the acral regions, such as the face and the distal arms and legs. It affects elderly women more than men and rarely occurs at a young age. The exact pathogenic mechanism of MCAH is not yet clearly understood. Read More

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Multinucleate cell angiohistiocytoma: Case report and literature review.

J Cutan Pathol 2019 Jan 19;46(1):59-61. Epub 2018 Nov 19.

Advanced Dermatology Associates, LTD, Allentown, Pennsylvania.

Multinucleate cell angiohistiocytoma is a rare, vascular, fibrohistiocytic proliferation that has a benign but progressive course. The clinical presentation is that of grouped red-purple papules and nodules characteristically located on the lower extremities in women. The histopathology shows a proliferation of narrow vessels within thickened collagen bundles associated with multinucleate giant cells. Read More

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January 2019

Generalized multinucleate cell angiohistiocytoma with involvement of palms and soles: An unusual manifestation.

Indian J Dermatol Venereol Leprol 2018 Jul-Aug;84(4):468-470

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

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November 2018

Case for diagnosis. Multinucleated cell angiohistiocytoma.

An Bras Dermatol 2018 03;93(2):291-293

Hospital de Santarém EPE, Santarém, Portugal.

Multinucleate cell angiohistiocytoma is a rare idiopathic benign fibrohistiocytic and vascular proliferation usually presenting as multiple asymptomatic papules, red to violaceous in colour, primarily located on the extremities of middle-aged females. This entity is probably underdiagnosed due to the lack of recognition by clinicians and pathologists. We describe a patient with a multinucleate cell angiohistiocytoma of the face, a less frequent localization, in order to increase awareness of this entity and elucidate its clinical, histopathological, and immunohistochemistry features. Read More

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Multinucleate cell angiohistiocytoma.

Cutis 2017 Dec;100(6):429-431

Southwest Skin Specialists, Phoenix, Arizona, USA.

Multinucleate cell angiohistiocytoma (MCAH) is a rare cutaneous entity described as grouped erythematous to violaceous papules. Histopathologic findings include vascular proliferations with multinucleate giant cells and dermal fibrosis. We report a case of MCAH in an 83-year-old white man affecting both the right anterior thigh and left posterior calf. Read More

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December 2017

Linear and Bilateral Multinucleated Cell Angiohistiocytoma (MCAH).

J Dermatol Case Rep 2016 Dec 31;10(4):58-61. Epub 2016 Dec 31.

Dermatology Unit, Catholic University of Sacred Heart, Rome, Italy.

Background: Multinucleated Cell Angiohistiocytoma (MCAH) is a rare disease, first described by Smith and Wilson Jones in 1985. Since then, less than 100 cases have been reported in the literature. Clinically it is characterized by papules or plaques arising from a specific anatomical area such as lower extremities, dorsum of the hands and face. Read More

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December 2016

Multinucleate giant cell angiohistiocytoma of the vaginal wall.

J Obstet Gynaecol 2017 Apr 26;37(3):395-397. Epub 2016 Dec 26.

a Provincial Health Care Services , Institute of Pathology, Santa Maria del Carmine Hospital , Rovereto , TN , Italy.

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Generalized multinucleate cell angiohistiocytoma: case report and literature review.

J Cutan Pathol 2017 Feb 28;44(2):125-134. Epub 2016 Nov 28.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Multinucleate cell angiohistiocytoma (MCAH) is an uncommon benign fibrohistiocytic and vascular proliferation, which usually occurs as slow-growing grouped reddish-brown to purple papules and nodules on the distal extremities or face. Patients with generalized MCAH are extremely rare and to our knowledge, there are no more than 11 cases reported previously in the medical literature.

Objective: To describe the clinical, histopathologic features and immunohistochemical characteristics of all reported cases of generalized MCAH and investigate any potential clinicopathological correlations. Read More

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February 2017

Multinucleate cell angiohistiocytoma of the lower vermilion lip: an unusual site.

G Ital Dermatol Venereol 2019 Feb 5;154(1):79-81. Epub 2016 Oct 5.

Department of Dermatology, S. Martino University Hospital and Institute for Research and Care, University of Genoa, Genoa, Italy.

Multinucleate cell angiohistiocytoma (MCA) represent an uncommon benign fibrohistiocytic vascular lesion that sometimes may go undiagnosed because of its clinical and histopathological similarities with benign fibrous histiocytoma and other soft-tissue neoplasms especially when localized on oral cavity or semi mucosa. We report the case of a solitary multinucleate cell angiohistiocytoma on the lower lip of a 46-year-old woman suggesting that this rare lesion should be considered in the differential diagnosis of the oral soft-tissue neoplasms. Read More

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February 2019

Multinucleate cell angiohistiocytoma-like features around a ganglion.

J Cutan Pathol 2016 Jan 9;43(1):88-90. Epub 2015 Sep 9.

Clinical Department of Dermatology & Venereology, Medical University Innsbruck, Innsbruck, Austria.

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January 2016

Generalized Eruptive Histiocytosis With Features of Multinucleate Cell Angiohistiocytoma.

Am J Dermatopathol 2016 Jun;38(6):470-2

*Private Dermatohistological Laboratory, Nuernberg, Germany †Institute of Pathology, Medical University Innsbruck, Innsbruck, Austria ‡Clinical Department of Dermatology and Venereology, Medical University Innsbruck, Innsbruck, Austria.

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Facial multinucleate cell angiohistiocytoma: long-term remission with 585 nm pulsed dye laser.

Authors:
V Richer H Lui

Clin Exp Dermatol 2016 Apr 12;41(3):312-3. Epub 2015 Aug 12.

Department of Dermatology and Skin Science, University of British Columbia and the Photomedicine Institute, Vancouver Coastal Health Research Institute, 835 West tenth Avenue, Vancouver, BC, Canada, V5Z 4E8.

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Generalized Multinucleate Cell Angiohistiocytoma.

J Cutan Med Surg 2015 May-Jun;19(3):323-5. Epub 2015 Mar 13.

Departments of Medicine and Pathology, Capital District Health Authority and Dalhousie University, Halifax, NS.

Background: There are less than 100 cases of multinucleate cell angiohistiocytoma (MCA) currently reported in the literature. It occurs as a localized, asymptomatic, benign proliferation of the skin, characterized histologically by irregular multinucleate cells. Due to its novelty, the etiology of the disease and treatment options are still under investigation. Read More

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October 2015

Multinucleate cell angiohistiocytoma: clinicopathological correlation of 142 cases with insights into etiology and pathogenesis.

Authors:
John W Frew

Am J Dermatopathol 2015 Mar;37(3):222-8

Dermatology Services, Skin and Cancer Foundation, University of New South Wales, Sydney, Australia.

Introduction: Multinucleate cell angiohistiocytoma (MCAH) is a peculiar dermatopathological entity described as asymptomatic grouped red-to-violaceous papules, developing over weeks to months without spontaneous regression. The histopathological findings comprise bizarre basophilic multinucleated cells (MC), small vessel inflammation, mild dermal fibrosis, and a sparse lymphohistiocytic infiltrate.

Aims And Methods: This study aimed to collate and analyze the clinical, histological, and immunohistochemical characteristics of all reported cases of MCAH from the international literature, and the presence or absence of concurrent chronic inflammatory or neoplastic phenomena to investigate any potential clinicopathological correlations, which may hint at the underlying pathophysiology of this condition. Read More

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Multinucleate cell angiohistiocytoma: a case report and review of the literature.

Dermatol Online J 2014 May 16;20(5):22610. Epub 2014 May 16.

Baylor College of Medicine.

Multinucleate cell angiohistiocytoma (MCAH) is a rare, benign vascular proliferation. Fewer than 80 cases have been reported to date, which may relate to under-recognition of this entity. Lesions are commonly asymptomatic and appear as erythematous to violaceous papules on the lower extremities and dorsal hands of middle-aged to elderly women. Read More

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Multinucleate cell angiohistiocytoma: a new case report with dermoscopy.

Dermatol Online J 2014 Mar 17;20(3). Epub 2014 Mar 17.

Coimbra University Hospital.

Multinucleate cell angiohistiocytoma (MCA) is a benign fibrohistiocytic and vascular proliferation usually located on the extremities. It may be underdiagnosed owing to lack of recognition by clinicians and pathologists. We report a 48-year-old man with asymptomatic grouped reddish papules on the dorsum of his right hand for 8 years. Read More

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Multinucleate cell angiohistiocytoma with hypertrophic nerves.

J Cutan Pathol 2013 Dec 30;40(12):1048-53. Epub 2013 Sep 30.

Department of Skin and V.D, B. J. Medical Government College and Sassoon General Hospital, Pune, India.

Multinucleate cell angiohistiocytoma (MCAH) represents a rare benign skin lesion characterized by multiple papules that are usually found on the distal extremities or face of middle-aged women. We report on a 60-year-old male with a history of monoclonal gammopathy and severe rheumatoid arthritis who had several asymptomatic red-to-livid papules grouped on the right side of his trunk. The lesions had been present for a few years and were gradually enlarging. Read More

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December 2013

Multiple asymptomatic violaceous macules on the thigh. Multinucleate cell angiohistiocytoma (MCAH).

JAMA Dermatol 2013 Mar;149(3):357-63

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA.

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Nonepithelial skin tumors with multinucleated giant cells.

Semin Diagn Pathol 2013 Feb;30(1):58-72

Department of Pathology, Hospital Clínico Universitario-INCLIVA, University of Valencia, Valencia, Spain.

Recognition of the different types of multinucleated giant cells in neoplastic and pseudotumoral lesions of the skin may be helpful in the differential diagnosis of these tumors. In this review, we will analyze the different types of multinucleated giant cells that can be found in nonepithelial cutaneous tumors and, more importantly, the clinicopathological context in which they are found. Touton giant cells are typically present in juvenile xanthogranuloma, necrobiotic xanthogranuloma, and some subtypes of xanthomas. Read More

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February 2013

Multiple papulonodular lesions on the dorsum of the hand: challenge. Multinucleate cell angiohistiocytoma (MCAH).

Am J Dermatopathol 2012 Apr;34(2):176, 226

Department of Pathology; Western General Hospital, Crewe Road, Edinburgh, United Kingdom.

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