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    57 results match your criteria Multinucleate Cell Angiohistiocytoma

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    Linear and Bilateral Multinucleated Cell Angiohistiocytoma (MCAH).
    J Dermatol Case Rep 2016 Dec 31;10(4):58-61. Epub 2016 Dec 31.
    Dermatology Unit, Catholic University of Sacred Heart, Rome, Italy.
    Background: Multinucleated Cell Angiohistiocytoma (MCAH) is a rare disease, first described by Smith and Wilson Jones in 1985. Since then, less than 100 cases have been reported in the literature. Clinically it is characterized by papules or plaques arising from a specific anatomical area such as lower extremities, dorsum of the hands and face. Read More

    Generalized multinucleate cell angiohistiocytoma: case report and literature review.
    J Cutan Pathol 2017 Feb 28;44(2):125-134. Epub 2016 Nov 28.
    Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Background: Multinucleate cell angiohistiocytoma (MCAH) is an uncommon benign fibrohistiocytic and vascular proliferation, which usually occurs as slow-growing grouped reddish-brown to purple papules and nodules on the distal extremities or face. Patients with generalized MCAH are extremely rare and to our knowledge, there are no more than 11 cases reported previously in the medical literature.

    Objective: To describe the clinical, histopathologic features and immunohistochemical characteristics of all reported cases of generalized MCAH and investigate any potential clinicopathological correlations. Read More

    Multinucleate cell angiohistiocytoma of the lower vermilion lip: an unusual site.
    G Ital Dermatol Venereol 2016 Oct 5. Epub 2016 Oct 5.
    DISSAL, Department of Dermatology, IRCCS-AOU S. Martino-IST, University of Genoa,Genoa, Italy - javor.medmail.com.
    Multinucleate cell angiohistiocytoma (MCA) represent an uncommon benign fibrohistiocytic vascular lesion that sometimes may go undiagnosed because of its clinical and hystopathological similarities with benign fibrous histiocytoma and other soft-tissue neoplasms especially when localized on oral cavity or semi mucosa. We report the case of a solitary multinucleate cell angiohistiocytoma on the lower lip of a 46-year old woman suggesting that this rare lesion should be considered in the differential diagnosis of the oral soft-tissue neoplasms. Read More

    Generalized Multinucleate Cell Angiohistiocytoma.
    J Cutan Med Surg 2015 May-Jun;19(3):323-5. Epub 2015 Mar 13.
    Departments of Medicine and Pathology, Capital District Health Authority and Dalhousie University, Halifax, NS.
    Background: There are less than 100 cases of multinucleate cell angiohistiocytoma (MCA) currently reported in the literature. It occurs as a localized, asymptomatic, benign proliferation of the skin, characterized histologically by irregular multinucleate cells. Due to its novelty, the etiology of the disease and treatment options are still under investigation. Read More

    Multinucleate cell angiohistiocytoma: clinicopathological correlation of 142 cases with insights into etiology and pathogenesis.
    Am J Dermatopathol 2015 Mar;37(3):222-8
    Dermatology Services, Skin and Cancer Foundation, University of New South Wales, Sydney, Australia.
    Introduction: Multinucleate cell angiohistiocytoma (MCAH) is a peculiar dermatopathological entity described as asymptomatic grouped red-to-violaceous papules, developing over weeks to months without spontaneous regression. The histopathological findings comprise bizarre basophilic multinucleated cells (MC), small vessel inflammation, mild dermal fibrosis, and a sparse lymphohistiocytic infiltrate.

    Aims And Methods: This study aimed to collate and analyze the clinical, histological, and immunohistochemical characteristics of all reported cases of MCAH from the international literature, and the presence or absence of concurrent chronic inflammatory or neoplastic phenomena to investigate any potential clinicopathological correlations, which may hint at the underlying pathophysiology of this condition. Read More

    Multinucleate cell angiohistiocytoma: a case report and review of the literature.
    Dermatol Online J 2014 May 16;20(5):22610. Epub 2014 May 16.
    Baylor College of Medicine.
    Multinucleate cell angiohistiocytoma (MCAH) is a rare, benign vascular proliferation. Fewer than 80 cases have been reported to date, which may relate to under-recognition of this entity. Lesions are commonly asymptomatic and appear as erythematous to violaceous papules on the lower extremities and dorsal hands of middle-aged to elderly women. Read More

    Multinucleate cell angiohistiocytoma: a new case report with dermoscopy.
    Dermatol Online J 2014 Mar 17;20(3). Epub 2014 Mar 17.
    Coimbra University Hospital.
    Multinucleate cell angiohistiocytoma (MCA) is a benign fibrohistiocytic and vascular proliferation usually located on the extremities. It may be underdiagnosed owing to lack of recognition by clinicians and pathologists. We report a 48-year-old man with asymptomatic grouped reddish papules on the dorsum of his right hand for 8 years. Read More

    Multinucleate cell angiohistiocytoma with hypertrophic nerves.
    J Cutan Pathol 2013 Dec 30;40(12):1048-53. Epub 2013 Sep 30.
    Department of Skin and V.D, B. J. Medical Government College and Sassoon General Hospital, Pune, India.
    Multinucleate cell angiohistiocytoma (MCAH) represents a rare benign skin lesion characterized by multiple papules that are usually found on the distal extremities or face of middle-aged women. We report on a 60-year-old male with a history of monoclonal gammopathy and severe rheumatoid arthritis who had several asymptomatic red-to-livid papules grouped on the right side of his trunk. The lesions had been present for a few years and were gradually enlarging. Read More

    Nonepithelial skin tumors with multinucleated giant cells.
    Semin Diagn Pathol 2013 Feb;30(1):58-72
    Department of Pathology, Hospital Clínico Universitario-INCLIVA, University of Valencia, Valencia, Spain.
    Recognition of the different types of multinucleated giant cells in neoplastic and pseudotumoral lesions of the skin may be helpful in the differential diagnosis of these tumors. In this review, we will analyze the different types of multinucleated giant cells that can be found in nonepithelial cutaneous tumors and, more importantly, the clinicopathological context in which they are found. Touton giant cells are typically present in juvenile xanthogranuloma, necrobiotic xanthogranuloma, and some subtypes of xanthomas. Read More

    Estrogen receptor alpha overexpression in multinucleate cell angiohistiocytoma: new insights into the pathogenesis of a reactive process.
    Am J Dermatopathol 2010 Oct;32(7):655-9
    Department of Anatomic Pathology, University of Modena and Reggio Emilia, Italy.
    Multinucleate cell angiohistiocytoma (MCAH) is a putative reactive skin lesion, which has been reported mostly in adult female patients, and hormones have been recently suggested as a factor influencing its development. To test this hypothesis, monoclonal anti-estrogen receptor (ER) a, anti-progesterone receptor (PR), anti-Factor XIIIa, and polyclonal anti-vascular endothelial growth factor (VEGF) antibodies were applied by immunohistochemistry on a series of 21 MCAHs and, compared to 10 cases of dermatofibroma (DF) and 5 cases of chronic dermatitis presenting multinucleate cells. On normal skin surrounding the lesions and in cases of DF and chronic dermatitis, ERa was expressed in few undifferentiated and differentiated sebocytes, in few cells of anagen follicles and perifollicular mesenchymal cells, and in scattered dermal fibrocytes. Read More

    Novel case of generalized multinucleate cell angiohistiocytoma.
    J Cutan Med Surg 2010 Jul-Aug;14(4):178-80
    Division of Dermatology and Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS.
    Background: multinucleate cell angiohistiocytoma is a rare benign fibrohistiocytic and vascular proliferation, typically characterized by the development of solitary papules, in an acral distribution in otherwise healthy late middle-aged to elderly women.

    Objective: our objectives are to present a novel case of generalized multinucleate cell angiohistiocytoma and to review the current literature regarding the clinical and histologic findings in this condition, as well as its potential causes and treatments.

    Observations: we describe a 35-year-old man who presented with generalized asymptomatic firm violaceous papules. Read More

    [Multinucleate cell angiohistiocytoma].
    Hautarzt 2010 May;61(5):373-6
    Klinik für Allergologie und Dermatologie, Universitätsklinikum RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.
    Multinucleate cell angiohistiocytoma is a rare, benign, usually asymptomatic fibrohistiocytic and vascular proliferation which occurs predominantly on the extremities of middle-aged women. Histology shows characteristic multinucleate cells and is indispensable for diagnosis. We present a 42-year-old man from Egypt who was diagnosed with multinucleate cell angiohistiocytoma on the left cheek. Read More

    Multinucleate cell angiohistiocytoma: report of three new cases and literature review.
    Dermatol Online J 2009 Feb 15;15(2). Epub 2009 Feb 15.
    Dept. of Dermatology, Ed. Herriot Hospital, Lyon cedex 03, France.
    Multinucleate cell angiohistiocytoma (MCA) is a rare benign vascular proliferation of the skin of unknown cause. About 75 cases have been reported previously. We present herein three new cases of MCA studied immunohistologically and present a review the relevant literature that delineates the salient clinicopathological features of this unusual entity. Read More

    Multinucleate cell angiohistiocytoma: an uncommon mucosal tumour.
    Clin Exp Dermatol 2009 Apr 24;34(3):333-6. Epub 2008 Nov 24.
    Department of Oral and Maxillofacial Pathology, University of Tenesee Health Sciences Center, Memphis, TN 38163, USA.
    Multinucleate cell angiohistiocytoma (MCAH) is an uncommon benign soft-tissue lesion with characteristic histological and immunohistochemical features. It is unclear if it represents a benign neoplasm or a reactive/inflammatory process. The overwhelming majority of these tumors have been described on cutaneous surfaces. Read More

    Multinucleate cell angiohistiocytoma. Report of five cases.
    J Cutan Pathol 2006 May;33(5):349-52
    Department of Dermatology, Complejo Hospitalario Universitario, Santiago de Compostela, Spain.
    Background: Multinucleate cell angiohistiocytoma is an infrequent and most likely non-neoplastic disorder usually seen in acral regions in elderly women. It presents clinically as asymptomatic red-to-brown tumors, with a tendency to confluence. It must be distinguished from other diverse cutaneous lesions, notably dermatofibroma, Kaposi sarcoma, and angiofibroma. Read More

    [Multinucleate cells angiohistiocytoma].
    Ann Dermatol Venereol 2005 Jun-Jul;132(6-7 Pt 1):546-9
    Service d'Anatomie Pathologique, Hôpital Saint-Louis, Paris.
    Introduction: Multinucleate cell angiohistiocytoma is a rare entity. We report two unusual cases of this lesion.

    Case Report: A 39 year-old man had presented since two years an arciform papular eruption of the forehead. Read More

    Multinucleate cell angiohistiocytoma: a new case report.
    J Eur Acad Dermatol Venereol 2005 Mar;19(2):208-11
    Service of Dermatology, Hospital of Cabueñes, Gijón, Spain.
    Multinucleate cell angiohistiocytoma (MCAH) was first described by Smith and Wilson-Jones in 1985. It is an uncommon entity but probably underdiagnosed because of lack of recognition by clinicians and pathologists. We report a 47-year-old man with asymptomatic grouped violaceous papules on the dorsum of the hands for 3 years. Read More

    Multinucleate cell angiohistiocytoma: a fibrohistiocytic proliferation with increased mast cell numbers and vascular hyperplasia.
    J Cutan Pathol 2002 Apr;29(4):232-7
    Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
    Background: Multinucleate cell angiohistiocytoma (MCAH) is an uncommon lesion clinically characterized by multiple papules usually located on the face and acral regions of elderly women. Histopathologically, MCAH is characterized by dermal vascular hyperplasia associated with increased number of factor XIIIa-positive fibrohistiocytic cells and multinucleate cells with scalloped borders.

    Methods: We report the clinical, histopathological and immunohistochemical features of three cases of MCAH, with ulstrastructural study in one of them. Read More

    Multinucleate cell angiohistiocytoma: report of two cases with no evidence of human herpesvirus-8 infection.
    J Cutan Pathol 2000 May;27(5):258-61
    Department of Dermatology, CHU Saint-Pierre, Brussels, Belgium.
    Multinucleate cell angiohistiocytoma (MCA) is a vascular tumor of unknown pathogenesis. Possible misinterpretation of this disorder with Kaposi's sarcoma (KS), a human herpesvirus-8 (HHV-8)-associated tumor, prompted us to look for this virus in two women with MCA. None of the multiple skin specimens obtained from both our patients produced amplified HHV-8 DNA. Read More

    Multinucleate-cell angiohistiocytoma occurring in a patient with mycosis fungoides.
    Cutis 1999 Mar;63(3):145-8
    Department of Dermatology, Allegheny University Hospitals, Philadelphia, Pennsylvania 19107, USA.
    Multinucleate-cell angiohistiocytoma (MCAH) is a benign vascular proliferation of unknown etiology. Clinically, MCAH presents as grouped, erythematous, or violaceous papules on the extremities in older women. These lesions often resemble Kaposi's sarcoma. Read More

    [Fibrohistiocytic skin lesions].
    Verh Dtsch Ges Pathol 1998 ;82:290-300
    Dermatohistopathologisches Labor, Universitätsklinik für Dermatologie, Universität Innsbruck, Osterreich.
    Aims: A new unifying concept of fibrohistiocytic skin lesions.

    Methods: Retrospective clinicopathologic study of more than 2,000 dermatofibromas (DF) recruited over the last two decades.

    Results: As the least common denominator all DF show a reactive fibrohistiocytic tissue response with variable epidermal hyperplasia, peripheral sclerosis and peripherally accentuated lymphohistiocytic tissue response. Read More

    [Dermatofibroma. A clinico-pathologic classification scheme].
    Pathologe 1998 Nov;19(6):412-9
    Institut für Pathologie, Universität Innsbruck, Osterreich.
    Dermatofibroma is a common benign fibrohistiocytic lesion which presents with a wide variety of clinicopathologic variants. This may cause great difficulties in delineation from a variety of benign and malignant tumours. According to their peculiarities we differentiate: 1. Read More

    Plaque-type multinucleate cell angiohistiocytoma.
    J Cutan Med Surg 1998 Oct;3(2):112-4
    Division of Dermatology, Vancouver Hospital & Health Sciences Centre, University of British Columbia, Vancouver, British Columbia, Canada.
    Background: Multinucleate cell angiohistiocytoma (MCAH) is a rare cutaneous disorder that usually presents as papules or nodules.

    Objective: This article reports a case of MCAH that appeared clinically as a large cutaneous plaque.

    Methods And Results: A 74-year-old woman presented with a large painless, dusky red, indurated plaque measuring 12 x 6 cm on the trunk that was found on histopathologic examination to be a MCAH. Read More

    Multinucleate cell angiohistiocytoma: a report of two cases.
    J Eur Acad Dermatol Venereol 1998 Jul;11(1):51-4
    Department of Dermatology, University of Turin, Italy.
    We report the clinical, histological and immunological features of two cases of multinucleate cell angiohistiocytoma (MCAH) in women of 32 and 53 years of age, respectively. Clinically, MCAH occurs mostly in middle-aged women and consists of crops of reddish-purple, dome-shaped papules especially on the limbs. Histologically, the reticular dermis presents an increased number of small vascular channels with plump endothelial cells embedded in a fibrohistiocitic stroma with numerous bizarre multinucleate cells. Read More

    Cutaneous vascular proliferations. Part III. Malignant neoplasms, other cutaneous neoplasms with significant vascular component, and disorders erroneously considered as vascular neoplasms.
    J Am Acad Dermatol 1998 Feb;38(2 Pt 1):143-75; quiz 176-8
    Department of Dermatology, Fundación Jiménez-Díaz, Universidad Autónoma, Madrid, Spain.
    In this third and last part of our review of cutaneous vascular proliferations we include malignant vascular neoplasms and a group of heterogeneous cutaneous neoplasms characterized by a significant vascular component. We also review some disorders that, in our opinion, have been erroneously considered as vascular neoplasms. We review the epidemiologic, histogenetic, clinical, and histopathologic aspects of Kaposi's sarcoma in its four distinctive variants (classic, African-endemic, immunosuppressive drug-associated, and AIDS-associated Kaposi's sarcoma). Read More

    Multinucleate cell angiohistiocytoma.
    Cutis 1997 Apr;59(4):190-2
    Department of Dermatology, University of São Paulo, Brazil.
    Multinucleate cell angiohistiocytoma (MCA) is a benign fibrohistiocytic vascular tumor affecting predominantly the acral sites in elderly women. The disorder is often confused clinically and histologically with Kaposi's sarcoma. We report the case of a 63-year-old woman with MCA and describe the main clinical and histopathologic features of this disorder. Read More

    Generalized multinucleate cell angiohistiocytoma.
    J Am Acad Dermatol 1996 Aug;35(2 Pt 2):320-2
    Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
    Multinucleate cell angiohistiocytoma is a rare benign fibrohistiocytic vascular condition that mainly affects middle-aged women. Grouped reddish-brown papules are found in the extremities. We describe a case of multinucleate cell angiohistiocytoma occurring in a 24-year-old man who presented with multiple papules on the trunk and extremities. Read More

    Clear cell dermatofibroma. Case report of an unusual fibrohistiocytic lesion.
    Am J Surg Pathol 1996 Apr;20(4):483-91
    Department of Dermatology, University of Innsbruck, Austria.
    A case of clear cell dermatofibroma is presented. Clinically, a 41-year-old woman exhibited a hard brown nodule on her instep that was assumed to be a dermatofibroma. Histologically, more than 90% of the lesion was composed of clear cells. Read More

    Multinucleate cell angiohistiocytoma. A review and report of four cases.
    Acta Derm Venereol 1995 Sep;75(5):337-9
    Clinic of Dermatology, Strasbourg, France.
    Multinucleate cell angiohistiocytoma (MCA) was first characterized by Smith & Wilson-Jones. Although only a few cases have been published, this very characteristic benign tumor is probably not rare. The clinical pictures are firm circumscribed papules, mainly of the hands, which progress slowly over the years. Read More

    Multinucleate cell angiohistiocytoma of the orbit.
    Am J Ophthalmol 1995 Sep;120(3):402-3
    Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
    Purpose: A 31-year-old had a five-year history of painless progressive swelling of her right upper eyelid.

    Method: A mass was removed from the superonasal aspect of the right orbit.

    Results: The orbital mass was composed of a collagenous stroma with capillary channels and irregular giant cells. Read More

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