1,983 results match your criteria Multinucleate Cell Angiohistiocytoma


Jumu is required for circulating hemocyte differentiation and phagocytosis in Drosophila.

Cell Commun Signal 2018 Dec 5;16(1):95. Epub 2018 Dec 5.

Department of Genetics, College of Life Sciences, Northeast Forestry University, Harbin, 150040, People's Republic of China.

Background: The regulatory mechanisms of hematopoiesis and cellular immunity show a high degree of similarity between insects and mammals, and Drosophila has become a good model for investigating cellular immune responses. Jumeau (Jumu) is a member of the winged-helix/forkhead (FKH) transcription factor family and is required for Drosophila development. Adult jumu mutant flies show defective hemocyte phagocytosis and a weaker defense capability against pathogen infection. Read More

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December 2018

A cargo model of yolk syncytial nuclear migration during zebrafish epiboly.

Development 2018 Dec 3. Epub 2018 Dec 3.

Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, USA

In teleost fish, the multinucleate yolk syncytial layer functions as an extraembryonic signaling center to pattern mesendoderm, coordinate morphogenesis and supply nutrients to the embryo. External yolk syncytial nuclei (e-YSN) undergo microtubule dependent movements that distribute the nuclei over the large yolk mass. How e-YSN migration proceeds, and the role of the yolk microtubules is not understood but it is proposed that e-YSN are pulled vegetally as the microtubule network shortens from the vegetal pole. Read More

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December 2018
1 Read

A case of multinucleate cell angiohistiocytoma in a 14-year old boy showing two different clinical and histopathological findings.

J Cutan Pathol 2018 Nov 29. Epub 2018 Nov 29.

Department of Dermatology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea.

Multinucleate cell angiohistiocytoma (MCAH) is a rare cutaneous disease entity characterized by multiple red-to-brown or violaceous papules usually located on the acral regions such as the face and the distal arms and legs. It affects elderly women more than men and hardly occurs at a young age. The exact pathogenic mechanism of MCAH is not yet clearly understood. Read More

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November 2018
1 Read

Extramedullary Haematopoiesis in Axillary Lymph Nodes of Breast Carcinoma Patients Receiving Neoadjuvant Chemotherapy: A Potential Diagnostic Pitfall.

Pathobiology 2018 Nov 13:1-6. Epub 2018 Nov 13.

Queen Elizabeth Hospital Birmingham and the University of Birmingham, Birmingham, United Kingdom.

Extramedullary haematopoiesis (EMH) in the axillary lymph node of breast cancer patients is extremely rare but when encountered can represent a diagnostic challenge. We aim to highlight this incidental finding as a diagnostic pitfall which can be mistaken for metastatic carcinoma (particularly of the metaplastic type). We report the case of a 68-year-old Caucasian female with a family history of cancer. Read More

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November 2018
5 Reads

Mid borderline leprosy in type Bα Blaschko linear pattern: a rare phenomenon.

Int J Dermatol 2018 Oct 21. Epub 2018 Oct 21.

Department of Skin & VD, SBH Govt Medical College, Chakkarbardi, Dhule, Maharashtra, India.

Introduction: Leprosy is a chronic granulomatous disease caused by M. leprae. It is a great imitator as it can manifest in different unusual and atypical ways. Read More

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October 2018
5 Reads

[Lentigo maligna and lentigo maligna melanoma: a clinicopathologic analysis of twenty-four cases].

Zhonghua Bing Li Xue Za Zhi 2018 Oct;47(10):769-774

Department of Pathology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

To study the clinicopathologic features, differential diagnosis and prognosis of lentigo maligna (LM) and lentigo maligna melanoma (LMM). Histopathologic evaluation and immunohistochemical study by HRP multimer method were carried out in 24 cases of LM and LMM from 2012 to 2017 at Fudan University Shanghai Cancer Center. The clinical information and follow-up data were analyzed. Read More

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October 2018
5 Reads

Histological Features of Shallow Placental Implantation Unify Early-Onset and Late-Onset Preeclampsia.

Authors:
Jerzy Stanek

Pediatr Dev Pathol 2018 Oct 9:1093526618803759. Epub 2018 Oct 9.

1 Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Preeclampsia is distinguishable from other hypertensive conditions of pregnancy by its high rates of decidual arteriopathy, the uterine type of chronic hypoxic placental injury, the occurrence of villous infarctions, and clusters of multinucleate trophoblasts in the maternal floor. To retrospectively study the clinical and placental phenotypes of 230 women with early-onset preeclampsia, 261 women with late-onset preeclampsia, and 5059 women without hypertension in pregnancy (comparative group), 24 clinical and 46 placental phenotypes were statistically compared (analysis of variance, χ with Bonferroni correction). The frequency of decidual arteriopathy (both hypertrophic and atherosis), patterns of chronic hypoxic placental injury, villous infarction, membrane laminar necrosis, membrane microscopic chorionic pseudocysts, clusters of maternal floor multinucleated trophoblasts, excessive number of extravillous trophoblasts, and intervillous thrombi was strikingly higher in both late-onset preeclampsia and early-onset preeclampsia than in the comparative group without hypertension in pregnancy. Read More

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October 2018
2 Reads

Multiple Sources for Sertoli Cells and Two Sertoli Phenotypes in the Adult Elasmobranch Testis: Insight from Two Species Belonging to Different Orders.

Anat Rec (Hoboken) 2018 Nov 19;301(11):1944-1954. Epub 2018 Oct 19.

Department of Health & Care, Faculty of Health Sciences, University of Tromsø - The Arctic University of Norway, Narvik, Norway.

Findings presented here for the chondrichthyans Prionace glauca and Isurus oxyrinchus show that the assembly of the spermatocyst and it's attached collecting duct are seamlessly connected developmental phenomena. The cyst's somatic cell component (i.e. Read More

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November 2018
5 Reads

Inflammation-associated miR-155 activates differentiation of muscular satellite cells.

PLoS One 2018 1;13(10):e0204860. Epub 2018 Oct 1.

Division of Cell Biology for Regenerative Medicine, Institute of Advanced Clinical Medicine, Kindai University Faculty of Medicine, Osaka, Japan.

Tissue renewal and muscle regeneration largely rely on the proliferation and differentiation of muscle stem cells called muscular satellite cells (MuSCs). MuSCs are normally quiescent, but they are activated in response to various stimuli, such as inflammation. Activated MuSCs proliferate, migrate, differentiate, and fuse to form multinucleate myofibers. Read More

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October 2018

A young patient with a lytic skull lesion.

J Clin Pathol 2018 Sep 26. Epub 2018 Sep 26.

Department of Haematology-Oncology, National University Cancer Institute Singapore, National University Health System, Singapore, Singapore.

Clinical Question: A man in his mid-20s presented with a 2-month history of an enlarging left-sided skull swelling associated with focal pain. His medical history and systems enquiry were otherwise unremarkable. Specifically, he had no neurological deficits and respiratory, skin or constitutional symptoms. Read More

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September 2018
6 Reads
2.920 Impact Factor

Extracellular matrix with defective collagen cross-linking affects the differentiation of bone cells.

PLoS One 2018 25;13(9):e0204306. Epub 2018 Sep 25.

Division of Bio-Prosthodontics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Fibrillar type I collagen, the predominant organic component in bone, is stabilized by lysyl oxidase (LOX)-initiated covalent intermolecular cross-linking, an important determinant of bone quality. However, the impact of collagen cross-linking on the activity of bone cells and subsequent tissue remodeling is not well understood. In this study, we investigated the effect of collagen cross-linking on bone cellular activities employing a loss-of-function approach, using a potent LOX inhibitor, β-aminopropionitrile (BAPN). Read More

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September 2018
2 Reads

Multinucleate cell angiohistiocytoma: Case report and literature review.

J Cutan Pathol 2018 Sep 24. Epub 2018 Sep 24.

Advanced Dermatology Associates, LTD, Allentown, Pennsylvania.

Multinucleate cell angiohistiocytoma is a rare, vascular, fibrohistiocytic proliferation that has a benign but progressive course. The clinical presentation is that of grouped red-purple papules and nodules characteristically located on the lower extremities in women. The histopathology shows a proliferation of narrow vessels within thickened collagen bundles associated with multinucleate giant cells. Read More

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September 2018

A GFP-fusion coupling FACS platform for advancing the metabolic engineering of filamentous fungi.

Biotechnol Biofuels 2018 24;11:232. Epub 2018 Aug 24.

1Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308 People's Republic of China.

Background: The filamentous fungus , the most widely used cellulase producer, also has promising applications in lignocellulose-based biorefinery: consolidated bioprocessing for the production of high value-added products. However, such applications are thwarted by the time-consuming metabolic engineering processes (design-build-test-learn cycle) for , resulted from (i) the spore separation-mediated purification as the multinucleate hyphae, (ii) transformant screening for high expression levels since unavailable of episomal expression system, and (iii) cases of inexpressible heterologous proteins.

Results: In this study, a GFP-fusion coupled fluorescence-activated cell sorting (FACS) platform was established to speed up the build and test process of the DBTL cycle, by enabling rapid selection for expressible heterologous genes and bypassing both laborious spore separation and transformant screening. Read More

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August 2018
2 Reads

Fine needle aspiration of giant cell tumor involving thyroid gland: A case report of an unprecedented entity.

Diagn Cytopathol 2018 Oct 26;46(10):879-882. Epub 2018 Aug 26.

Department of Pathology, West China Hospital of Sichuan University, Chengdu, China.

Fine-needle aspiration (FNA) is commonly used to evaluate both primary thyroid lesions (PTLs) and secondary thyroid neoplasms (STNs). Although STNs are uncommon, metastases from various primary sites particularly the kidney, lung, and breast have been previously described. Giant cell tumor (GCT) is typically found in the metaphyseal-epiphyseal area of long bones that seldom involves thyroid. Read More

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October 2018

Characterization of the Testicular Toxicity of 3-Nitro-1,2,4-Triazol-5-One and 2,4-Dinitroanisole in Rats ( Rattus norvegicus).

Int J Toxicol 2018 Sep/Oct;37(5):364-372. Epub 2018 Aug 22.

4 US Army Medical Institute of Chemical Defense, Aberdeen Proving Ground, MD, USA.

Nitrotriazolone (3-nitro-1,2,4-triazol-5-one; NTO) and dinitroanisole (2,4-dinitroanisole; DNAN), insensitive energetic materials used in explosive formulations, have induced testicular toxicity and oligospermia in repeated-dose oral toxicity tests. To identify the target site of testicular toxicity of NTO and DNAN, Sprague Dawley rats were orally dosed with NTO (500 mg/kg/d) or DNAN (50 or 100 mg/kg/d) in corn oil for 1, 3, 7, or 14 days. Degeneration of germinal epithelium occurred in multiple tubule stages on days 7 and 14 in treated rats. Read More

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MADS-Box Transcription Factor Regulates Dimorphic Transition, Conidiation, and Germination of .

Front Microbiol 2018 7;9:1781. Epub 2018 Aug 7.

Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

The opportunistic human pathogen exhibits a temperature-dependent dimorphic transition, which is closely related with its pathogenicity. This species grows as multinucleate mycelia that produce infectious conidia at 25°C, while undergoes a dimorphic transition to generate uninucleate yeast form cells at 37°C. The mechanisms of phenotype switching are not fully understood. Read More

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August 2018
8 Reads

Growth arrested live-attenuated Leishmania infantum KHARON1 null mutants display cytokinesis defect and protective immunity in mice.

Sci Rep 2018 Aug 2;8(1):11627. Epub 2018 Aug 2.

Instituto René Rachou - Fiocruz Minas, 31390-009, Belo Horizonte, Brazil.

There is no safe and efficacious vaccine against human leishmaniasis available and live attenuated vaccines have been used as a prophylactic alternative against the disease. In order to obtain an attenuated Leishmania parasite for vaccine purposes, we generated L. infantum KHARON1 (KH1) null mutants (ΔLikh1). Read More

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August 2018
1 Read

Reduction of ATPase activity in the rice kinesin protein Stemless Dwarf 1 inhibits cell division and organ development.

Plant J 2018 Nov 1;96(3):620-634. Epub 2018 Sep 1.

National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.

Several kinesins, the ATP-driven microtubule (MT)-based motor proteins, have been reported to be involved in many basic processes of plant development; however, little is known about the biological relevance of their ATPase activity. Here, we characterized the Oryza sativa (rice) stemless dwarf 1 (std1) mutant, showing a severely dwarfed phenotype, with no differentiation of the node and internode structure, abnormal cell shapes, a shortened leaf division zone and a reduced cell division rate. Further analysis revealed that a substantial subset of cells was arrested in the S and G2/M phases, and multinucleate cells were present in the std1 mutant. Read More

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November 2018
1 Read

Expression of N471D strumpellin leads to defects in the endolysosomal system.

Dis Model Mech 2018 09 13;11(9). Epub 2018 Sep 13.

Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, 50931 Cologne, Germany

Hereditary spastic paraplegias (HSPs) are genetically diverse and clinically characterised by lower limb weakness and spasticity. The N471D and several other point mutations of human strumpellin (Str; also known as WASHC5), a member of the Wiskott-Aldrich syndrome protein and SCAR homologue (WASH) complex, have been shown to cause a form of HSP known as spastic paraplegia 8 (SPG8). To investigate the molecular functions of wild-type (WT) and N417D Str, we generated Str cells and ectopically expressed Str-GFP or Str-GFP in Str and WT cells. Read More

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September 2018
1 Read
4.970 Impact Factor

Haplosporidium pinnae sp. nov., a haplosporidan parasite associated with mass mortalities of the fan mussel, Pinna nobilis, in the Western Mediterranean Sea.

J Invertebr Pathol 2018 Sep 10;157:9-24. Epub 2018 Jul 10.

Centro de Investigacións Mariñas (CIMA), Consellería do Mar, Xunta de Galicia, Pedras de Corón s/n, 36620 Vilanova de Arousa, Spain; Departamento de Ciencias de la Vida, Universidad de Alcalá, 28871 Alcalá de Henares, Spain. Electronic address:

This study provides morphological and molecular characterization of a new species, Haplosporidium pinnae), very likely responsible for mass mortality of fan mussels, Pinna nobilis, in the Western Mediterranean Sea. The parasite was found in dead or moribund P. nobilis but did not occur in healthy fan mussels from locations that were not affected by abnormal mortality. Read More

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September 2018

Primary Cutaneous Osteosarcoma.

S D Med 2018 Apr;71(4):164-166

Department of Pathology, University of South Dakota, Sanford School of Medicine, Sioux Falls, South Dakota.

Primary cutaneous osteosarcoma is an exceedingly rare malignant mesenchymal neoplasm of the skin which produces bone, osteoid, or chondroid material and does not involve the underlying bone. The most common site for extraskeletal osteosarcoma is in the deep soft tissues of the thigh, upper extremities, and retroperitoneum; however, it may occur anywhere in the body. Involvement of the skin is rare and when it does occur it is more commonly due to metastatic disease rather than a primary malignancy. Read More

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April 2018
2 Reads

Histological changes secondary to wire coil placement in breast tissue and lymph nodes.

Virchows Arch 2018 Sep 8;473(3):285-291. Epub 2018 Jul 8.

Pathology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.

We describe the histological and immunohistochemical features of the changes produced by spiral coil localization wires in the breast parenchyma and lymph nodes of a total of 100 patients undergoing surgery for different breast lesions. Coil wires produced cystic lesions containing a hyaline, mucous-like, PAS-negative fluid. Cavities were lined by cells of variable morphology ranging from synovial-like cells (with a conspicuous epithelial appearance) to mononuclear or multinucleate histiocytic cells that expressed CD68, but were negative for keratins. Read More

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September 2018
11 Reads

Expression of both Arabidopsis γ-tubulin genes is essential for development of a functional syncytium induced by Heterodera schachtii.

Plant Cell Rep 2018 Sep 12;37(9):1279-1292. Epub 2018 Jun 12.

Department of Botany, Faculty of Agriculture and Biology, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-776, Warsaw, Poland.

Key Message: After initial up-regulation, expression of TUBG1 and TUBG2 is significantly down-regulated in mature syncytia, but lack of expression of either of γ-tubulin genes reduces numbers of nematode infections and developing females. Infective second stage juveniles of sedentary plant parasitic nematode Heterodera schachtii invade the root vascular tissue and induce a feeding site, named syncytium, formed as a result of cell hypertrophy and partial cell wall dissolution leading to a multinucleate state. Syncytium formation and maintenance involves a molecular interplay between the plant host and the developing juveniles leading to rearrangements and fragmentation of the plant cytoskeleton. Read More

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September 2018
8 Reads

Introduction of Large Sequence Inserts by CRISPR-Cas9 To Create Pathogenicity Mutants in the Multinucleate Filamentous Pathogen Sclerotinia sclerotiorum.

MBio 2018 06 26;9(3). Epub 2018 Jun 26.

Department of Plant Pathology, University of Florida, Gainesville, Florida, USA

The necrotrophic fungal plant pathogen is responsible for substantial global crop losses annually resulting in localized food insecurity and loss of livelihood. Understanding the basis of this broad-host-range and aggressive pathogenicity is hampered by the quantitative nature of both host resistance and pathogen virulence. To improve this understanding, methods for efficient functional gene characterization that build upon the existing complete genome sequence are needed. Read More

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June 2018
6 Reads

Monocyte Subsets Have Distinct Patterns of Tetraspanin Expression and Different Capacities to Form Multinucleate Giant Cells.

Front Immunol 2018 8;9:1247. Epub 2018 Jun 8.

Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.

Monocytes are able to undergo homotypic fusion to produce different types of multinucleated giant cells, such as Langhans giant cells in response to infection or foreign body giant cells in response to implanted biomaterials. Monocyte fusion is highly coordinated and complex, with various soluble, intracellular, and cell-surface components mediating different stages of the process. Tetraspanins, such as CD9, CD63, and CD81, are known to be involved in cell:cell fusion and have been suggested to play a role in regulating homotypic monocyte fusion. Read More

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June 2018
9 Reads

Parasitic pneumonia in roe deer (Capreolus capreolus) in Cornwall, Great Britain, caused by Varestrongylus capreoli (Protostrongylidae).

BMC Vet Res 2018 Jun 22;14(1):198. Epub 2018 Jun 22.

Pathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire, AL9 7TA, UK.

Background: Roe deer (Capreolus capreolus) became extinct over large areas of Britain during the post mediaeval period but following re-introductions from Europe during the 1800s and early 1900s the population started to recover and in recent decades there has been a spectacular increase. Many roe deer are shot in Britain each year but despite this there is little published information on the diseases and causes of mortality of roe deer in Great Britain.

Case Presentation: The lungs of two hunter-shot roe deer in Cornwall showed multiple, raised, nodular lesions associated with numerous protostrongylid-type nematode eggs and first stage larvae. Read More

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June 2018
2 Reads

Decoupling of Nuclear Division Cycles and Cell Size during the Coenocytic Growth of the Ichthyosporean Sphaeroforma arctica.

Curr Biol 2018 Jun 7;28(12):1964-1969.e2. Epub 2018 Jun 7.

Institut de Biologia Evolutiva (CSIC-Universitat Pompeu Fabra), Passeig Maritím de la Barceloneta 37-49, 08003 Barcelona, Catalonia, Spain; Departament de Genètica, Microbiologia i Estadística, Universitat de Barcelona, Avinguda Diagonal 643, 08028 Barcelona, Catalonia, Spain; ICREA, Passeig Lluís Companys 23, 08010 Barcelona, Catalonia, Spain.

Coordination of the cell division cycle with the growth of the cell is critical to achieve cell size homeostasis [1]. Mechanisms coupling the cell division cycle with cell growth have been described across diverse eukaryotic taxa [2-4], but little is known about how these processes are coordinated in organisms that undergo more complex life cycles, such as coenocytic growth. Coenocytes (multinucleate cells formed by sequential nuclear divisions without cytokinesis) are commonly found across the eukaryotic kingdom, including in animal and plant tissues and several lineages of unicellular eukaryotes [5]. Read More

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Generalized multinucleate cell angiohistiocytoma with involvement of palms and soles: An unusual manifestation.

Indian J Dermatol Venereol Leprol 2018 Jul-Aug;84(4):468-470

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

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November 2018
2 Reads

Does being multi-headed make you better at solving problems? A survey of Physarum-based models and computations.

Phys Life Rev 2018 May 22. Epub 2018 May 22.

Center of Mathematics for Social Creativity, Research Institute for Electronic Science, Hokkaido University, Sapporo 060-0812, Japan; Global Station for Soft Matter, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo 060-0815, Japan.

Physarum polycephalum, a single-celled, multinucleate slime mould, is a seemingly simple organism, yet it exhibits quasi-intelligent behaviour during extension, foraging, and as it adapts to dynamic environments. For these reasons, Physarum is an attractive target for modelling with the underlying goal to uncover the physiological mechanisms behind the exhibited quasi-intelligence and/or to devise novel algorithms for solving complex computational problems. The recent increase in modelling studies on Physarum has prompted us to review the latest developments in this field in the context of modelling and computing alike. Read More

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May 2018
3 Reads
7.480 Impact Factor

Perinatal Lethal Gaucher Disease due to RecNcil Recombinant Mutation in the Gene Presenting with Hydrops Fetalis and Severe Congenital Anemia.

Case Rep Pathol 2018 9;2018:2549451. Epub 2018 May 9.

Mater Pathology, Mater Health Services, South Brisbane, QLD, Australia.

A 35-year-old woman presented at 27-week gestation with hypertension and pedal edema. Antenatal scan showed hydrops fetalis and growth restriction. Cordocentesis showed severe fetal anemia. Read More

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May 2018
1 Read

Enterococcus gallinarum meningitis: a case report and literature review.

BMC Infect Dis 2018 May 21;18(1):231. Epub 2018 May 21.

Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.

Background: As an opportunistic pathogen, E. gallinarum mainly leads to nosocomial infections, and it's multi-drug resistance has gained more and more attention. Central nervous system infections caused by E. Read More

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Plexiform Atypical Spitz Tumor With Rosette-Like Giant Cells: A Histologic and Immunohistochemical Study on a Case Suggesting Ganglioneuroblastic Differentiation: Review of the Literature and Considerations on Histogenesis.

Am J Dermatopathol 2018 Dec;40(12):903-907

Department of Biomedicine, Internal Medicine, and Specialized, Medicine (DIBIMIS), Section of Dermatology, University of Palermo, AOUP Paolo Giaccone, Palermo, PA, Italy.

Spitz nevi, atypical Spitz tumors and Spitzoid melanoma, the three clinicopathologic forms that constitute the spectrum of the Spitz-type melanocytic lesions, share a histologic picture characterized by large spindle and/or epithelioid ganglion-like cells, with various admixtures of multinucleate bizarre cells. This remarkable cytology has always been interpreted as an unusual, as well as unexplained form of atypia. We report a case of atypical Spitz tumor with Homer Wright-like rosettes, a feature characteristic of ganglioneuroblastic proliferation. Read More

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December 2018
3 Reads

The secreted Theileria annulata Ta9 protein contributes to activation of the AP-1 transcription factor.

PLoS One 2018 8;13(5):e0196875. Epub 2018 May 8.

Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, Faculté de Médecine, Université Paris Descartes - Sorbonne Paris Cité, Paris, France.

Theileria annulata is an obligate intracellular protozoan parasite of the phylum Apicomplexa. Theileria sporozoites invade bovine leukocytes and develop into a multinucleate syncytial macroschizont that causes uncontrolled proliferation and dissemination of infected and transformed leukocytes. Activator protein 1 (AP-1) is a transcription factor driving expression of genes involved in proliferation and dissemination and is therefore a key player in Theileria-induced leukocytes transformation. Read More

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August 2018
5 Reads

DiSUMO-LIKE Interacts with RNA-Binding Proteins and Affects Cell-Cycle Progression during Maize Embryogenesis.

Curr Biol 2018 May 3;28(10):1548-1560.e5. Epub 2018 May 3.

Cell Biology and Plant Biochemistry, Biochemie-Zentrum Regensburg, University of Regensburg, 93053 Regensburg, Germany. Electronic address:

Embryogenesis in flowering plants is initiated by an asymmetric zygote division, generating two daughter cells that are the precursors of different cell lineages. Little is known about the molecular players regulating activation and progression of zygote development, establishment of asymmetry, and the plant-specific process of cell-plate formation. Here, we report the function of the ubiquitin-like modifier DiSUMO-LIKE (DSUL) for early embryo development in maize. Read More

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Case for diagnosis. Multinucleated cell angiohistiocytoma.

An Bras Dermatol 2018 Mar;93(2):291-293

Hospital de Santarém EPE, Santarém, Portugal.

Multinucleate cell angiohistiocytoma is a rare idiopathic benign fibrohistiocytic and vascular proliferation usually presenting as multiple asymptomatic papules, red to violaceous in colour, primarily located on the extremities of middle-aged females. This entity is probably underdiagnosed due to the lack of recognition by clinicians and pathologists. We describe a patient with a multinucleate cell angiohistiocytoma of the face, a less frequent localization, in order to increase awareness of this entity and elucidate its clinical, histopathological, and immunohistochemistry features. Read More

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March 2018
3 Reads

An efficient Agrobacterium-mediated transformation method for aflatoxin generation fungus Aspergillus flavus.

J Microbiol 2018 May 2;56(5):356-364. Epub 2018 May 2.

School of Life Sciences, Anhui Agricultural University, Hefei, 230036, P. R. China.

Aspergillus flavus often invade many important corps and produce harmful aflatoxins both in preharvest and during storage stages. The regulation mechanism of aflatoxin biosynthesis in this fungus has not been well explored mainly due to the lack of an efficient transformation method for constructing a genome-wide gene mutant library. This challenge was resolved in this study, where a reliable and efficient Agrobacterium tumefaciens-mediated transformation (ATMT) protocol for A. Read More

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May 2018
3 Reads

Detection and phylogenetic characterization of porcine circovirus 2 from pigs in Mozambique.

J Vet Diagn Invest 2018 May;30(3):342-347

Department of Veterinary Pathology (Laisse, Pereira, De Lorenzo, Bianchi, Pavarini, Driemeier) and Laboratory of Virology (Souza and Canal), School of Veterinary Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

Porcine circovirus-associated diseases (PCVADs), caused by porcine circovirus 2 (PCV-2), have a significant economic impact on the swine industry worldwide. In Africa, there is little information, to date, regarding the occurrence of PCV-2, and it has not been reported in Mozambique's swine population. We randomly collected mesenteric lymph nodes ( n = 111) from slaughtered pigs from 9 districts in southern Mozambique. Read More

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May 2018
1 Read

Variation in nuclear size and PD-L2 positivity correlate with aggressive chromophobe renal cell carcinoma.

Ann Diagn Pathol 2018 Jun 10;34:31-35. Epub 2018 Jan 10.

Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address:

Chromophobe renal cell carcinoma (CRCC) is not amenable to International Society for Urologic Pathology-endorsed nucleolar grading. Novel grading approaches were proposed, but the rarity of adverse pathology hampers their discriminatory value. We investigate simple linear micrometer measurements and a proposed immunostain in CRCCs. Read More

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June 2018
9 Reads

[Clinical and genetic analysis of a pediatric patient with sodium taurocholate cotransporting polypeptide deficiency].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Apr;20(4):279-284

Department of Pediatrics, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.

Sodium taurocholate cotransporting polypeptide (NTCP) deficiency is an inborn error of bile acid metabolism caused by mutations of SLC10A1 gene. This paper reports the clinical and genetic features of a patient with this disease. A 3. Read More

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April 2018
2 Reads

La nécrobiose lipoïdique: à propos d’un cas: Necrobiosis lipoidica: about a case.

Pan Afr Med J 2018 3;29. Epub 2018 Jan 3.

Centre Hospitalier Universitaire Hassan II, Fès, Maroc.

Necrobiosis lipoidica is a rare granulomatous dermatosis. It occurs in 0.3-1. Read More

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May 2018
3 Reads

Fibroblastic osteosarcoma with epithelioid and squamous differentiation in a dog.

J Vet Diagn Invest 2018 Jul 9;30(4):593-597. Epub 2018 Apr 9.

Athens Veterinary Diagnostic Laboratory, Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA (Rissi).

A fibroblastic osteosarcoma with epithelioid and squamous differentiation in the distal femur of a 9-y-old spayed female Greyhound dog is described. Grossly, the tumor consisted of a pale-white, firm-to-hard mass that replaced the medullary and cortical areas of the distal end of the right femur. Histologically, the mass was composed predominantly of spindle cells admixed with areas of mineralized and non-mineralized osteoid matrix that were surrounded by stellate osteoblasts and scattered multinucleate giant cells, consistent with the diagnosis of a fibroblastic osteosarcoma. Read More

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July 2018
2 Reads

Src signaling in a low-complexity unicellular kinome.

Sci Rep 2018 Mar 29;8(1):5362. Epub 2018 Mar 29.

Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY, 11794, USA.

Creolimax fragrantissima is a member of the ichthyosporean clade, the earliest branching holozoan lineage. The kinome of Creolimax is markedly reduced as compared to those of metazoans. In particular, Creolimax possesses a single non-receptor tyrosine kinase: CfrSrc, the homolog of c-Src kinase. Read More

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Induction of Mitotic Catastrophe in Human Cervical Cancer Cells After Administration of Aloe-emodin.

Anticancer Res 2018 04;38(4):2037-2044

Faculty of Management, University of Warsaw, Warsaw, Poland.

Background: Aloe-emodin is an anthraquinone with potential pharmacological properties, including numerous antitumor properties. The purpose of the study was to determine whether aloe-emodin induces mitotic death in cervical cancer cells.

Materials And Methods: Analysis of morphological changes as surrogate mitotic death indicators in HeLa cells was carried out using optical, fluorescence and electron microscopy. Read More

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April 2018
3 Reads

Differential Organ-targeting and Cellular Characteristics of Metastatic Human Pancreatic Cancer Cell Lines in Mouse Models.

Anticancer Res 2018 04;38(4):1927-1935

AntiCancer, Inc. San Diego, CA, U.S.A.

Background/aim: The lethal characteristic of pancreatic cancer is metastasis which is recalcitrant to currently-used chemotherapy. Our aim was to understand metastasis at the cellular level. We previously reported that multi-nucleate cells or spindle cells were more prominent in pancreatic cancer metastasis than in the primary tumor. Read More

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April 2018
1 Read

Septic presentation of a giant fibroepithelial polyp of the vulva.

BMJ Case Rep 2018 Mar 23;2018. Epub 2018 Mar 23.

Department of Obstetrics and Gynaecology, Royal Hospital, Muscat, Oman.

Fibroepithelial stromal polyps are mesenchymal lesions occurring typically in reproductive age women with a predilection for the vulvo-vaginal region. Malignancy may mimic this polyp in morphology, rendering further investigations including detailed histopathology mandatory. Histologically its characteristic features are stellate and multinucleate stromal cells identified near the epithelial-stromal interface. Read More

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March 2018
4 Reads

Carcinosarcoma mimicking a feline injection-site sarcoma in a cat.

Vet Clin Pathol 2018 Jun 8;47(2):297-302. Epub 2018 Feb 8.

Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences (SGGW), Warsaw, Poland.

A 15-year-old spayed female domestic short-haired cat with cutaneous/subcutaneous well-circumscribed, alopecic mass approximately 25 × 30 mm in diameter, localized to the left shoulder region was brought to the veterinary surgery department. Despite the suggestive location and macroscopic appearance, feline injection-site sarcoma was not suspected based on the cytologic examination of fine-needle aspirates. The tumor was surgically resected, and tissue sections were evaluated microscopically. Read More

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June 2018
11 Reads

Ex vivo expansion of alveolar macrophages with Mycobacterium tuberculosis from the resected lungs of patients with pulmonary tuberculosis.

PLoS One 2018 5;13(2):e0191918. Epub 2018 Feb 5.

Scientific Department, Ural Research Institute for Phthisiopulmonology, National Medical Research Center of Tuberculosis and Infectious Diseases of Ministry of Health of the Russian Federation, Yekaterinburg, Russia.

Tuberculosis (TB), with the Mycobacterium tuberculosis (Mtb) as the causative agent, remains to be a serious world health problem. Traditional methods used for the study of Mtb in the lungs of TB patients do not provide information about the number and functional status of Mtb, especially if Mtb are located in alveolar macrophages. We have developed a technique to produce ex vivo cultures of cells from different parts of lung tissues surgically removed from patients with pulmonary TB and compared data on the number of cells with Mtb inferred by the proposed technique to the results of bacteriological and histological analyses used for examination of the resected lungs. Read More

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March 2018
2 Reads

Effect of l-caldesmon on osteoclastogenesis in RANKL-induced RAW264.7 cells.

J Cell Physiol 2018 Sep 25;233(9):6888-6901. Epub 2018 Mar 25.

Boston Biomedical Research Institute, Watertown, Massachusetts.

Non-muscle caldesmon (l-CaD) is involved in the regulation of actin cytoskeletal remodeling in the podosome formation, but its function in osteoclastogenesis remains to be determined. In this study, RANKL-induced differentiation of RAW264.7 murine macrophages to osteoclast-like cells (OCs) was used as a model to determine the physiological role of l-CaD and its phosphorylation in osteoclastogenesis. Read More

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September 2018
2 Reads

Lupus miliaris disseminatus faciei.

An Bras Dermatol 2017 Nov-Dec;92(6):851-853

Department of Dermatology, Santarém Hospital, Santarém, Portugal.

Lupus miliaris disseminatus faciei is a rare inflammatory dermatosis of unknown etiology that primarily affects young adults. Clinically, it is characterized by an asymptomatic papular eruption mainly involving the central face, typically on and around the eyelids. Characteristic histopathological features include dermal epithelioid cell granulomas with central necrosis and surrounding lymphocytic infiltrate with multinucleate giant cells. Read More

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April 2018
3 Reads

Multinucleate cell angiohistiocytoma.

Cutis 2017 Dec;100(6):429-431

Southwest Skin Specialists, Phoenix, Arizona, USA.

Multinucleate cell angiohistiocytoma (MCAH) is a rare cutaneous entity described as grouped erythematous to violaceous papules. Histopathologic findings include vascular proliferations with multinucleate giant cells and dermal fibrosis. We report a case of MCAH in an 83-year-old white man affecting both the right anterior thigh and left posterior calf. Read More

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December 2017
4 Reads