28,466 results match your criteria Multifocal Motor Neuropathy With Conduction Blocks


Autoimmune encephalitis following alemtuzumab treatment of multiple sclerosis.

Mult Scler Relat Disord 2018 Dec 3;28:31-33. Epub 2018 Dec 3.

Department of Neurology, St Vincent's Hospital, 390 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia.

Secondary autoimmune disorders are a recognised complication of alemtuzumab treatment for multiple sclerosis. We report a case of autoimmune encephalitis manifesting as a polymorphic epilepsia partialis continua / status epilepticus seven months after the second course of alemtuzumab in a patient with previous autoimmune hypothyroidism and immune thrombocytopenic purpura. An MRI revealed multifocal cortical abnormalities and neuronal loss was evident on biopsy. Read More

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December 2018
1 Read

Binocular Visual Function with Staged Implantation of Diffractive Multifocal Intraocular Lenses with Three Add Powers.

Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Tokyo Dental Collage Suidobashi Hospital.

Purpose: To evaluate the binocular visual function and depth of focus after staged implantation of diffractive multifocal intraocular lenses (MIOLs) with three different add powers following cataract removal.

Design: Prospective comparative case series.

Methods: Setting: Institutional. Read More

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December 2018

Heterozygosity of p16 expression in an oral squamous cell carcinoma with associated loss of heterozygosity and copy number alterations.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Faculty of Health Sciences, Department of Oral Pathology and Oral Biology, School of Dentistry, University of Pretoria, Pretoria, South Africa.

Background: Oral field cancerization describes a multifocal development process involving many cells at once in response to prolong exposure to carcinogens. This case demonstrated differential p16 expression in different sections of the same HPV negative tumor on the floor of mouth in a patient with history of prolonged smoking.

Methods: Histological examination, presence of HPV infection and OncoScan analysis of DNA extracted from two well-defined areas with different p16 expression profiles were performed. Read More

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December 2018

Progressive Multifocal Leukoencephalopathy in Primary Immunodeficiencies.

J Clin Immunol 2018 Dec 14. Epub 2018 Dec 14.

Department of Haematology, Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades, France et Université Paris Descartes, 149 rue de Sèvres, 75015, Paris, France.

Purpose: Progressive multifocal leukoencephalopathy (PML) is a rare but severe demyelinating disease caused by the polyomavirus JC (JCV) in immunocompromised patients. We report a series of patients with primary immune deficiencies (PIDs) who developed PML.

Methods: Retrospective observational study including PID patients with PML. Read More

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December 2018

Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites.

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S75-S92

Department of Histopathology, King Edward Memorial Hospital and School for Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia (C.J.R.S.) Department of Pathology, Brigham and Women's Hospital (C.P.C.) Department of Pathology, Massachusetts General Hospital and Harvard Medical School (E.O.), Boston, Massachusetts Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK (W.G.M.) Department of Pathology, Memorial-Sloan Kettering Cancer Center, New York, New York (K.J.P.) Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California (J.K.R.) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M.) Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (V.P.) Pathological Oncology Group and Pathology Department, Hospital Arnau de Vilanova, Lleida, Spain (X.M.-G.) Departments of Pathology and Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland (B.M.R.).

In most cases of suspected endometrial neoplasia tumor origin can be correctly assigned according to a combination of clinical, radiologic, and pathologic features, even when the latter are based upon the examination of relatively small biopsy samples. However there are well-recognized exceptions to this rule which continue to create diagnostic difficulty, and sometimes difficulties persist even after the detailed examination of resection specimens. Among the most common problems encountered in practice are the distinction of primary endometrial and primary endocervical adenocarcinomas, and the determination of tumor origin when there is synchronous, multifocal involvement of gynecologic tract sites, for example the endometrium and the ovary. Read More

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January 2019

Cervical Spinal Cord Stimulation for the Vegetative State: A Preliminary Result of 12 Cases.

Neuromodulation 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.

Objectives: Data on the treatment of the vegetative state (VS) with cervical spinal cord stimulation (cSCS) are limited and prognostic factors are inconclusive. In this study, we present our experience of treating 12 VS patients with cSCS and discuss the prognostic factors.

Methods: Twelve VS patients were enrolled. Read More

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December 2018

Multifocal multiphoton volumetric imaging approach for high-speed time-resolved Förster resonance energy transfer imaging in vivo.

Opt Lett 2018 Dec;43(24):6057-6060

In this Letter, we will discuss the development of a multifocal multiphoton fluorescent lifetime imaging system where four individual fluorescent intensity and lifetime planes are acquired simultaneously, allowing us to obtain volumetric data without the need for sequential scanning at different axial depths. Using a phase-only spatial light modulator (SLM) with an appropriate algorithm to generate a holographic pattern, we project a beamlet array within a sample volume of a size, which can be preprogrammed by the user. We demonstrate the capabilities of the system to image live-cell interactions. Read More

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December 2018

Disease burden and social impact of pediatric chronic nonbacterial osteomyelitis from the patient and family perspective.

Pediatr Rheumatol Online J 2018 Dec 14;16(1):78. Epub 2018 Dec 14.

Pediatric Rheumatology, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.

Background: Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disorder that if left untreated can result in bone destruction and severe continuing pain due to persistent inflammation. The impact this chronic disease has on the daily lives of affected children and their families is not well known. The purpose of this study is to understand the disease burden and socioeconomic and psychological impact of CNO from the patients' and families' perspectives and identify areas of improvement for patient care and reduced disease burden based on patients' and families' responses. Read More

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December 2018

A well differentiated neuroendocrine tumor of the jejunum with peritoneal carcinomatosis: A case report.

Mol Clin Oncol 2018 Dec 4;9(6):651-655. Epub 2018 Oct 4.

First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Neuroendocrine tumors (NETs), belong to a group of neoplasms that arise from neuroendocrine cells and express markers such as synaptophysin and chromogranin A. The digestive system (DS) is the most common site of NET development. The World Health Organization classification divides NETs into low grade (G1-G2) tumors (NETs) and high grade carcinomas [neuroendocrine carcinomas (NECs)], based on mitotic index and histological criteria. Read More

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December 2018

Surgical outcomes after reoperation for recurrent non-skull base meningiomas.

Authors:

J Neurosurg 2018 Nov 1:1-9. Epub 2018 Nov 1.

OBJECTIVERecurrent meningiomas are primarily managed with radiation therapy or repeat resection. Surgical morbidity after reoperation for recurrent meningiomas is poorly understood. Thus, the objective of this study was to report surgical outcomes after reoperation for recurrent non-skull base meningiomas. Read More

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November 2018

Combination of serum microRNAs and ultrasound profile as predictive biomarkers of diagnosis and prognosis for papillary thyroid microcarcinoma.

Oncol Rep 2018 Oct 9. Epub 2018 Oct 9.

Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

Circulating microRNAs (miRNAs) are promising diagnostic markers in various types of cancers, including papillary thyroid carcinoma (PTC). However, there is sparse information reported with regards to miRNA expression in papillary thyroid microcarcinoma (PTMC) or concerning the role of a combination of miRNAs and ultrasound (US) in the diagnosis of PTMC before surgery. Therefore, we designed a study that aimed to evaluate miRNA expression levels and their potential associations with US findings and determine whether miRNAs could be used as diagnostic and prognostic biomarkers of PTMC. Read More

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October 2018

mutations cause variable phenotypes of developmental and epileptic encephalopathy.

Epilepsia Open 2018 Dec 1;3(4):495-502. Epub 2018 Nov 1.

Department of Pediatrics Showa University School of Medicine Shinagawa-ku, Tokyo Japan.

Objective: Vitamin B-dependent epilepsies are treatable disorders caused by variants in several genes, such as ,, and others. Recently, biallelic variants in formerly known as , were identified as a novel cause of vitamin B-dependent epilepsies. Our objective was to further delineate the phenotype of mutation. Read More

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December 2018

Surgical Resection for Recurrent Intrahepatic Cholangiocarcinoma.

World J Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of General, Visceral and Transplant Surgery, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.

Background: Although after R0 resection of intrahepatic cholangiocarcinoma (ICC) recurrence is frequent, most guidelines do not address strategies for this. The aim of this study was to analyze the outcome of repeated resection and to determine criteria when repeated resection is reasonable.

Methods: Between 2008 and 2016, we consecutively collected all cases of ICC (n = 176) in a prospective database and further analyzed them with a focus on tumor recurrence, its surgical treatment, overall survival and recurrence-free survival. Read More

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December 2018

[Magnetic resonance imaging features for primary brain lymphoma].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Oct;43(10):1118-1122

Department of Diagnostic Radiology, Hunan Cancer Hospital, Changsha 410013, China.

Objective: To investigate the magnetic resonance imaging (MRI) features for primary brain lymphoma and improve its diagnosis and differential diagnosis.
 Methods: The clinical and MRI data from 14 patients with primary brain lymphoma were retrospectively reviewed.
 Results: Fourteen patients, including 5 males and 9 females, were (55±8) years old. Read More

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October 2018

Increased IP-10 production by blood-nerve barrier in multifocal acquired demyelinating sensory and motor neuropathy and multifocal motor neuropathy.

J Neurol Neurosurg Psychiatry 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Japan

Objective: Dysfunction of the blood-nerve barrier (BNB) plays important roles in chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN). The aim of the present study was to identify the candidate cytokines/chemokines that cause the breakdown of the BNB using sera from patients with CIDP and MMN.

Methods: We determined the levels of 27 cytokines and chemokines in human peripheral nerve microvascular endothelial cells (PnMECs) after exposure to sera obtained from patients with CIDP variants (typical CIDP and multifocal acquired demyelinating sensory and motor neuropathy [MADSAM]), MMN and amyotrophic lateral sclerosis (ALS), and healthy controls (HC), using a multiplexed fluorescent bead-based immunoassay system. Read More

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December 2018

Longitudinal Chromatic Aberration and Polychromatic Image Quality Metrics of Intraocular Lenses.

J Refract Surg 2018 Dec;34(12):832-838

Purpose: To measure longitudinal chromatic aberration (LCA) of various intraocular lenses (IOLs) and to assess LCA effects on polychromatic image quality with a focus on multifocal IOL designs.

Methods: The LCA values of four multifocal IOL models (three diffractive models: AT LARA 829MP and AT LISA 809M [both from Carl Zeiss Meditec AG, Jena, Germany] and Restor SN6AD1 [Alcon Laboratories, Inc., Fort Worth, TX] and one refractive model [Mini Well Ready; SIFI Medtech, Sant'Antonio, Italy]) were compared with that of their monofocal counterparts. Read More

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December 2018

Clinical Outcomes Using a Novel Image-Guided Planning System in Patients With Cataract and IOL Implantation.

J Refract Surg 2018 Dec;34(12):824-831

Purpose: To determine the proportion of eyes with preexisting astigmatism achieving 0.50 diopters (D) or less of residual refractive cylinder 3 months after either implantation of toric intraocular lenses (IOLs) or corneal incisions using the VERION system (Alcon Laboratories, Inc., Fort Worth, TX) measurement module and digital markers for microscope (M) and laser (L). Read More

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December 2018
2 Reads

Safety and Efficacy of Rituximab in Multiple Sclerosis: A Retrospective Observational Study.

J Immunol Res 2018 12;2018:9084759. Epub 2018 Nov 12.

Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanon.

Objective: To evaluate the efficacy and safety of rituximab in multiple sclerosis in a clinical practice setting.

Methods: Clinical data for all adult patients with multiple sclerosis (MS) treated with off-label rituximab at a single MS center in Lebanon between March 2008 and April 2017 were retrospectively collected from medical charts. The main efficacy outcomes assessed were annualized relapse rate (ARR) and proportion of patients free from relapses, disability progression, or magnetic resonance imaging (MRI) activity. Read More

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November 2018
2 Reads

Systemic mastocytosis in adults: 2019 update on diagnosis, risk stratification and management.

Am J Hematol 2018 Dec 8. Epub 2018 Dec 8.

Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Overview: Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast cells (MC) in extra-cutaneous organs.

Diagnosis: The major criterion is presence of multifocal clusters of abnormal MC in the bone marrow. Minor diagnostic criteria include elevated serum tryptase level, abnormal MC CD25 expression, and presence of KITD816V mutation. Read More

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December 2018
9 Reads

Combined flecainide and sotalol therapy for multifocal atrial tachycardia in cardio-facio-cutaneous syndrome.

Pediatr Int 2018 Nov;60(11):1036-1037

Department of Pediatric Cardiology, Okinawa Children's Medical Center, Okinawa, Japan.

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November 2018
1 Read

Flexible focusing pattern realization of centimeter-scale planar super-oscillatory lenses in parallel fabrication.

Nanoscale 2018 Dec 11. Epub 2018 Dec 11.

Key Laboratory of Micro/Nano Systems for Aerospace (Ministry of Education), Northwestern Polytechnical University, Xi'an 710072, China. and Shaanxi Province Key Laboratory of Micro and Nano Electro-Mechanical Systems, Northwestern Polytechnical University, Xi'an 710072, China.

Planar super-oscillatory lenses (SOLs) can exert far-field foci beyond the diffraction limit free from the contribution of evanescent waves. However, the reported design methods of SOLs are always complicated and divergent, leading to a poor control over the desired focusing patterns. Furthermore, the existing device sizes of SOLs are mainly within hundreds of micrometers accompanied by a subwavelength-scale feature size. Read More

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December 2018
1 Read

New Approach to Oncoplastic Breast Conservation: Combining Autologous Volume Replacement and the Wise-pattern Mammaplasty.

Plast Reconstr Surg Glob Open 2018 Oct 16;6(10):e1987. Epub 2018 Oct 16.

Georgia Breast Surgery, Lawrenceville, Ga.

Background: Oncoplastic breast-conserving surgery describes a set of techniques that allow for generous oncological resection with immediate tumor-specific reconstruction. These techniques are classically divided into either volume displacement (local breast flaps and or reduction mammaplasty/mastopexy strategies) versus volume replacement strategies (transfer of autologous nonbreast tissue from a local or distant site and, less commonly, implant placement). There have been few descriptions of merging these 2 classical approaches to facilitate breast-conserving surgery. Read More

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October 2018

Chronic Recurrent Multifocal Osteomyelitis - A Case Series from India.

Indian J Orthop 2018 Nov-Dec;52(6):672-677

Pediatric Rheumatology Clinic, Indira Gandhi Institute of Child Health and Columbia Asia Hospital, Bengaluru, Karnataka, India.

Background: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare auto-inflammatory disease of the bone. It tends to be multifocal and usually the symptoms tend to run for months and years before diagnosis is usually made. The objective of our study was to understand the clinical presentation and short-term response to treatment of CRMO patients. Read More

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December 2018

[Aortic bicarotid subclavian trifurcation bypass grafting combined with coronary aortic bypass grafting].

Angiol Sosud Khir 2018 ;24(4):146-149

Scientific Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia.

Presented herein is the result of a successful simultaneous operation: carotid endarterectomy on the left + aortic-carotid prosthetic repair on the left + prosthetic repair of the brachiocephalic trunk + graft-subclavian bypass procedure on the left + graft-coronary bypass prosthetic repair of the anterior descending artery with an autovein and coronary aortic bypass grafting of the right coronary artery with an autovein. The chosen method of surgical correction was characterized by a high level of technical difficulty. Retrospectively, the correctness of the implemented surgical policy was confirmed by the worked out in our institution automated decision-making support system for choosing optimal strategy of revascularization in multifocal atherosclerosis. Read More

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January 2018

Indications for ascending aorta-bifemoral bypass grafting in patients with IHD and occlusion of the infrarenal aorta.

Angiol Sosud Khir 2018 ;24(4):133-144

Federal Centre of Cardiovascular Surgery under the RF Ministry of Public Health, Penza, Russia.

The problem concerning surgical decision-making in patients with significant atherosclerotic lesions of arteries of more than one basin will, probably, be important for cardiovascular surgeons for more than one decade. Even the centres possessing experience in several thousand cases of successful treatment of multifocal atherosclerosis have from time to time been facing non-trivial clinical situations requiring a non-standard decision the recommendations for which could hardly be found in the guidelines available, if at all. This article describes the technique and immediate results of an operation making it possible to simultaneously carry out revascularization of the myocardium and lower limbs in patients diagnosed as having a critical coronary lesion and Leriche syndrome with no intervention on the abdominal portion of the aorta. Read More

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January 2018

[Results of a single-centre study of open and endovascular operations of prosthetic repair of abdominal aortic aneurysms].

Angiol Sosud Khir 2018 ;24(4):126-130

National Medical Research Centre named after V.A. Almazov under the RF Ministry of Public Health, Saint Petersburg, Russia.

Objective: The purpose of the study was to assess surgical outcomes in patients suffering from an infrarenal abdominal aortic aneurysm and treated at the Department of Cardiovascular Surgery #2 of the National Medical Research Centre named after V.A. Almazov. Read More

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January 2018

Simultaneous Axial Multifocal Imaging using a Single Acoustical Transmission: a Practical Implementation.

IEEE Trans Ultrason Ferroelectr Freq Control 2018 Dec 5. Epub 2018 Dec 5.

Standard ultrasound imaging techniques rely on sweeping a focused beam across a field of view; however, outside the transmission focal depth, image resolution and contrast are degraded. High-quality deep tissue in vivo imaging requires focusing the emitted field at multiple depths, yielding high resolution and high contrast ultrasound images but at the expense of a loss in frame rate. Recent developments in ultrasound technologies have led to user-programmable systems, which enable real-time dynamic control over the phase and apodization of each individual element in the imaging array. Read More

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December 2018

"The other side of the coin": understanding noninvasive follicular tumor with papillary-like nuclear features in Unifocal and multifocal settings.

Hum Pathol 2018 Dec 7. Epub 2018 Dec 7.

IPATIMUP, Institute of Molecular Pathology and Immunology of University of Porto, Porto, Portugal; I3S, Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal; Department of Pathology, Medical Faculty of Porto University, Porto, Portugal. Electronic address:

The recent description of noninvasive follicular tumor with papillary-like nuclear features (NIFTP) creates several diagnostic and therapeutic challenges for both the pathologist and the attending clinician. Given the concern about overtreatment of these neoplasms, the best way to manage the patients by a surgical procedure and post-surgical follow-up is still under discussion. We aimed to identify predictors of synchronous disease (eg, bilateral cancers) that can influence the appropriate type of surgery and long-term surveillance. Read More

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December 2018
1 Read

Reappraising localized juvenile spongiotic gingival hyperplasia.

J Am Dent Assoc 2018 Dec 7. Epub 2018 Dec 7.

Background: Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a gingival lesion of unknown cause. The purpose of this study is to present a series of LJSGH cases and compare the findings with the literature.

Methods: After obtaining institutional review board approval, cases of biopsy-proven LJSGH from 2008 through 2018 were retrieved from the University of Pittsburgh Oral Pathology Biopsy Service archives and reviewed. Read More

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December 2018
2 Reads

[Epithelioid hemangioendothelioma].

Bull Cancer 2018 Dec 4. Epub 2018 Dec 4.

Centre Oscar Lambret, département d'oncologie médicale, 3, rue Frédéric Combemale, 59000 Lille, France; Hôpital Claude Huriez, service d'oncologie médicale, rue Michel Polonowski, 59000 Lille, France. Electronic address:

We describe herein the inaugural manifestations, the radiological and histological diagnosis criteria for and the outcome of epithelioid hemangioendothelioma (EHE). Most of EHE (90%) display a specific reciprocal chromosomic translocation t(1;3)(p36;q23-25), which is associated with the synthesis of fusion protein WWTR1/CAMTA1. EHE are low-grade vascular sarcomas. Read More

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December 2018

The X Factor.

Surv Ophthalmol 2018 Dec 3. Epub 2018 Dec 3.

Associate Professor, Departments of Clinical Neurosciences and Surgery, University of Calgary.

A 45-year-old Caucasian woman presented with chronic bilateral, painless, progressive, peripheral vision loss. She was found to have bilateral optic atrophy and non-enhancing multifocal white matter lesions on magnetic resonance imaging of the brain. Cerebrospinal fluid analysis showed elevated myelin basic protein. Read More

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December 2018
5 Reads

Prognostic value of unifocal and multifocal positive surgical margins in a large series of robot-assisted radical prostatectomy for prostate cancer.

World J Urol 2018 Dec 5. Epub 2018 Dec 5.

Department of Urology, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland.

Purpose: To evaluate the prognostic value of positive surgical margins (PSM) focality for the prediction of biochemical recurrence (BCR) in patients undergoing robotic-assisted radical prostatectomy (RARP) for prostate cancer.

Methods: All men with clinically localized prostate cancer undergoing RARP in our tertiary referral centre between May 2005 and August 2016 were retrospectively identified. Patients with neoadjuvant therapy were excluded. Read More

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December 2018
4 Reads

Patient-reported outcomes of multifocal and accommodating intraocular lenses: analysis of 117 patients 2-10 years after surgery.

Clin Ophthalmol 2018 12;12:2297-2304. Epub 2018 Nov 12.

Harvard Eye Associates, Laguna Hills, CA, USA,

Purpose: The purpose of this study was to determine the satisfaction levels of patients at least 2 years after cataract surgery implantation with bilateral accommodating or bilateral multifocal intraocular lenses (IOLs) and to determine the relative rate of spectacle independence and adverse symptoms in that same time frame.

Design: Patient questionnaire administered in a single-center private practice at least 2 years after cataract surgery with presbyopia-correcting IOL implantation.

Methods: Patients who had undergone uncomplicated cataract surgery with an accommodating or multifocal IOL implant were eligible for inclusion. Read More

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November 2018

Mixed Invasive Ductal and Lobular Carcinoma of the Breast: Prognosis and the Importance of Histologic Grade.

Oncologist 2018 Dec 5. Epub 2018 Dec 5.

Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Background: The diagnosis of mixed invasive ductal and lobular carcinoma (IDC-L) in clinical practice is often associated with uncertainty related to its prognosis and response to systemic therapies. With the increasing recognition of invasive lobular carcinoma (ILC) as a distinct disease subtype, questions surrounding IDC-L become even more relevant. In this study, we took advantage of a detailed clinical database to compare IDC-L and ILC regarding clinicopathologic and treatment characteristics, prognostic power of histologic grade, and survival outcomes. Read More

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December 2018
3 Reads

Transformation of Recurrent Respiratory Papillomatosis: Squamous Cell Carcinoma in a Pregnant Teen.

Ann Thorac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Cardiothoracic Surgery, Heart and Vascular Institute, Cleveland Clinic. Cleveland. Ohio. United States. Electronic address:

Recurrent Respiratory Papillomatosis (RRP) is a rare intractable benign disease with a bimodal age distribution. We present a rare case of malignant transformation of juvenile-onset RRP in a 19-year old pregnant female, who was found to have a right upper lobe mass and cavitary nodules bilaterally that were biopsy proven to be node negative, multifocal squamous cell carcinoma. In her second trimester, she underwent Video Assisted Thoracoscopic (VATS) right upper lobectomy and middle lobe lateral segmentectomy, followed by left lower lobe segmentectomy nine months later. Read More

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November 2018
1 Read

Tau Is Elevated in Pediatric Patients on Extracorporeal Membrane Oxygenation.

ASAIO J 2018 Nov 28. Epub 2018 Nov 28.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.

Neurologic injury is a known and feared complication of extracorporeal membrane oxygenation (ECMO). Neurologic biomarkers may have a role in assisting with early identification of such. Axonal biomarker tau has not been investigated in the pediatric ECMO population. Read More

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November 2018
2 Reads

A modified staging of early and intermediate hepatocellular carcinoma based on single tumour >7 cm and multiple tumours beyond up-to-seven criteria.

Aliment Pharmacol Ther 2018 Dec 2. Epub 2018 Dec 2.

Hepatopancreatobiliary Surgery Department I, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China.

Background: The Barcelona Clinic Liver Cancer (BCLC) staging system is the most widely used staging system for hepatocellular carcinoma (HCC). However, the classifications of early (BCLC-A) and intermediate (BCLC-B) stage HCC remain controversial.

Aim: To refine the staging of BCLC-A and -B. Read More

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December 2018
1 Read

Similarities and differences between three different types of white dot syndrome and the therapeutic possibilities.

Rom J Ophthalmol 2018 Jul-Sep;62(3):183-187

Anatomy Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

White dot syndromes consists a group of inflammatory eye diseases with an unknown etiology involving the external retina, retinal pigment epithelium, choroid or combinations of them. They affect one or both eyes, at the same time or not. White dot syndromes are often self-limited, with a variable prognosis, depending on the type of the disease. Read More

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December 2018
1 Read

A Case of Multifocal Tuberculosis Involving Skin and Bone: An Uncommon Presentation.

Indian Dermatol Online J 2018 Nov-Dec;9(6):458-460

Department of Dermatology, Venereology and Leprosy, K S Hegde Medical Academy, affiliated to NITTE (Deemed to be University), Mangalore, Karnataka, India.

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December 2018
1 Read

Epidemiology of Subcutaneous Mycoses in Northeast India: A Retrospective Study.

Indian J Dermatol 2018 Nov-Dec;63(6):496-501

Department of Dermatology and STD, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Background: Subcutaneous mycoses, although rare, are frequently reported from northeast India. Their spectrum varies with geographic region.

Materials And Methods: We evaluated clinical records and histopathological features of subcutaneous mycoses cases seen during April 2013 to March 2017. Read More

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December 2018
1 Read

Primary Meningeal Rhabdomyosarcoma of the Spinal Cord of a Young Dog with Neuromelanocytosis and Multiple Cutaneous Neurofibromas.

J Comp Pathol 2018 Nov 25;165:57-61. Epub 2018 Oct 25.

Frederick National Laboratory for Cancer Research, National Cancer Institute, Fort Detrick, Frederick, Maryland, USA.

A 7-week-old male black Labrador retriever puppy was presented for post-mortem examination following progressive hindlimb paralysis and multiple masses within the skin. A highly compressive and infiltrative intradural mass was found within the T9-T11 spinal cord. Microscopical and immunohistochemical analysis revealed features compatible with spindle cell rhabdomyosarcoma (RMS). Read More

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November 2018
1 Read

Malignant Cutaneous Peripheral Nerve Sheath Tumour with Rhabdomyosarcomatous Differentiation (Triton Tumour) in a Domestic Cat.

J Comp Pathol 2018 Nov 18;165:1-5. Epub 2018 Oct 18.

Department of Pathobiology and Population Sciences, The Royal Veterinary College, Hatfield, Hertfordshire, UK.

Divergent differentiation is encountered frequently within human malignant peripheral nerve sheath tumours (MPNSTs). The new component is often a rhabdomyosarcoma, but in animals this specific form of divergent differentiation within MPNSTs has only been reported once (in a dog). Incisional wedge biopsy of a locally extensive, ventral abdominal wall mass, which extended from the dermis to the subcutis, from a 12-year-old female domestic shorthaired cat, was performed. Read More

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November 2018
3 Reads

Cerebral Edema and Elevated Intracranial Pressure.

Authors:
Matthew A Koenig

Continuum (Minneap Minn) 2018 Dec;24(6):1588-1602

Purpose Of Review: This article reviews the management of cerebral edema, elevated intracranial pressure (ICP), and cerebral herniation syndromes in neurocritical care.

Recent Findings: While corticosteroids may be effective in reducing vasogenic edema around brain tumors, they are contraindicated in traumatic cerebral edema. Mannitol and hypertonic saline use should be tailored to patient characteristics including intravascular volume status. Read More

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December 2018
1 Read

Pancreatic cancer arising from the remnant pancreas after pancreatectomy: a multicenter retrospective study by the Kyushu Study Group of Clinical Cancer.

J Gastroenterol 2018 Dec 4. Epub 2018 Dec 4.

Department of Surgery and Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: After initial pancreatic resection, local recurrence of pancreatic cancer (PC) or new primary PC can develop in the remnant. There are limited data available regarding this so-called remnant PC. The aim of this retrospective study was to clarify the clinical features and establish a treatment strategy for remnant PC. Read More

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December 2018
1 Read

Shared decision-making within goal-setting in rehabilitation: a mixed-methods study.

Clin Rehabil 2018 Dec 4:269215518815251. Epub 2018 Dec 4.

University of Birmingham, Birmingham, UK.

Objectives:: To assess the extent of shared decision-making within goal-setting meetings and explore patient-reported factors that influenced their participation to shared decision-making about their goals.

Design:: A two-phase explanatory sequential mixed-methods study, using questionnaires and interviews.

Setting:: A rehabilitation centre and patients' homes. Read More

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December 2018

Productive Propagation of Rift Valley Fever Phlebovirus Vaccine Strain MP-12 in Rousettus aegyptiacus Fruit Bats.

Viruses 2018 Nov 30;10(12). Epub 2018 Nov 30.

Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany.

Rift Valley fever phlebovirus (RVFV), the causative agent of an emerging zoonotic disease in Africa and Arabia, can infect a variety of species, predominantly ruminants, camelids, and humans. While clinical symptoms are mostly absent in adult ruminants and camelids, RVFV infection may lead to a serious, sometimes fatal disease in humans. Virus transmissions between individuals and between species mainly occur through mosquito bites, but direct or even indirect contact with infectious materials may also result in infection. Read More

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November 2018
2 Reads

Colonic metastasis from infiltrating ductal breast carcinoma in a male patient: A case report.

Int J Surg Case Rep 2018 Nov 16;54:34-38. Epub 2018 Nov 16.

Department of Surgery, Palmetto Healthcare System, University of South Carolina Medical School, 2 Medical Park Road, Columbia, SC 29203, United States. Electronic address:

Introduction: A colonic metastasis from infiltrating breast ductal carcinoma is a rare phenomenon in the literature, especially in a male.

Presentation Of Case: We present a rare case of a 55-year-old male with a past medical history of breast cancer who presented with signs and symptoms of appendicitis. A computed tomography (CT) scan revealed acute appendicitis in addition to a 2. Read More

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November 2018
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An autopsy case of progressive multifocal leukoencephalopathy after rituximab therapy for malignant lymphoma.

Neuropathology 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology, Kurume University School of Medicine, Kurume, Japan.

Progressive multifocal leukoencephalopathy (PML) is a rare fatal demyelinating disease of the central nervous system caused by reactivation of the JC virus (JCV), which is named after the initials of the patient from whom the virus was first isolated. JCV is highly prevalent worldwide, infects humans in early childhood, and the infection persists throughout the course of life in latent form. The present paper deals with the second autopsy case report of rituximab-associated PML in Japan. Read More

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December 2018
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Multifocal Versus Conventional Unifocal Diverticulitis: A Comparison of Clinical and Transcriptomic Characteristics.

Dig Dis Sci 2018 Dec 3. Epub 2018 Dec 3.

Division of Colon and Rectal Surgery, Department of Surgery, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA, 17033-0850, USA.

Background: The management of diverticulitis is compromised by difficulty in identifying patients who require surgery for recurrent or persistent disease. Here, we introduce the concept of multifocal diverticulitis (MFD), characterized by multiple episodes of diverticulitis occurring at different locations within the colon.

Aims: To compare clinical characteristics, success of surgical management, and colonic transcriptomes of MFD patients to patients with conventional unifocal diverticulitis (UFD). Read More

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December 2018
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