129 results match your criteria Multifocal Motor Neuropathy With Conduction Blocks


Magnetic resonance neurography in diagnosing childhood chronic inflammatory demyelinating polyradiculoneuropathy.

Brain Dev 2021 Feb 21;43(2):352-356. Epub 2020 Oct 21.

Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.

Background: Peripheral nerve imaging is increasingly recognized as a powerful tool to evaluate nerve hypertrophy in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and Charcot-Marie-Tooth diseases (CMT), whereas data in pediatric patients are limited.

Case Description: We describe the case of a 15-year-old Japanese girl with asymmetric demyelinating polyneuropathy, who, at the age of 10 years, was initially diagnosed with a demyelinating form of CMT. Fluorescence in situ hybridization for peripheral myelin 22 was negative, and already-known pathogenic variants were not detected by whole-genome sequencing, and nerve conduction studies revealed multifocal conduction blocks. Read More

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February 2021

Hyperacute relapse of Lewis-Sumner syndrome during influenza A (H1N1) virus infection.

BMC Neurol 2020 Nov 24;20(1):427. Epub 2020 Nov 24.

Department of Neurology, Unidade Local de Saúde de Matosinhos, Hospital Pedro Hispano, Sra. da Hora, Portugal.

Background: Lewis-Sumner Syndrome (LSS) is considered an asymmetric sensory-motor variant of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), mostly affecting the limbs distally, with electrophysiological evidence of multifocal motor conduction blocks. Cranial nerve involvement is present in a minority. Various well-known infectious agents, directly or via the host's immune responses, may trigger or exacerbate acute and chronic peripheral neuropathies, which may manifest clinically through a multitude of signs and symptoms. Read More

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November 2020

Multifocal Motor Neuropathy with Persistent Conduction Block: The Seminal Case.

Eur Neurol 2020 11;83(6):639-642. Epub 2020 Nov 11.

Department of Anatomy and Department of Neuromuscular diseases, CHRU Besançon, University of Franche-Comté, Besançon, France,

Although multifocal motor neuropathy (MMN) is now recognized as a distinct, albeit rare, neurological condition, the path to its recognition was long and winding. This article provides an insight into the medical history of MMN "patient zero" and the first scientific publication that led to the recognition of MMN by the medical community. Multifocal motor neuropathy is nowadays recognized as a disease that produces asymmetric muscle weakness and cramping, with spontaneous motor unit activity (fasciculations and myokymia) but without sensory disorder. Read More

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November 2020

In the borderland of multifocal motor neuropathy and chronic inflammatory demyelinating polyradiculopathy.

Neurol Sci 2021 Mar 19;42(3):1131-1134. Epub 2020 Oct 19.

Institute of Neuroradiology, Kepler University Hospital, Linz, Austria.

Chronic inflammatory demyelinating polyradiculopathy (CIDP) and multifocal motor neuropathy (MMN) are seen as distinct entities with marked differences in pathophysiology and clinical, laboratory, and imaging features. We report a patient with an immune-mediated neuropathy in the borderland of CIDP and MMN, whose magnetic resonance imaging and cerebrospinal fluid (CSF) features strongly resembled CIDP, while the clinical course and treatment response suggested the diagnosis of MMN without conduction blocks. There is strong evidence that MMN is not a variant of CIDP and that these conditions can be separated pathologically. Read More

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Comparison of MRI and motor evoked potential with triple stimulation technique for the detection of brachial plexus abnormalities in multifocal motor neuropathy.

Muscle Nerve 2020 03 20;61(3):325-329. Epub 2019 Dec 20.

Referral Centre for Neuromuscular Diseases and ALS, Hôpital La Timone, Marseille, France.

Background: Conduction blocks (CB) are the diagnostic hallmark of multifocal motor neuropathy (MMN). Conventional nerve conduction studies cannot detect CB above Erb's point. Our purpose was to compare the performance of the motor evoked potential with triple stimulation technique (MEP-TST) and MRI in the detection of abnormalities of the brachial plexus. Read More

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Antiganglioside antibodies in neurological diseases.

J Neurol Sci 2020 Jan 9;408:116576. Epub 2019 Nov 9.

Department of Neurology, Poznan University of Medical Sciences, Poland.

Gangliosides are sialylated glycosphingolipids, highly abundant in our nervous system. Antibodies targeting gangliosides are usually developed as a consequence of molecular mimicry following infections. Antiganglioside antibodies are implicated in many neurological disorders such as acute and chronic polyradiculoneuropathies which includes different variants of Guillain-Barré syndrome, chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathy. Read More

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January 2020

Childhood-onset multifocal motor neuropathy with IgM antibodies to GM2 and GalNac-GD1a.

Brain Dev 2020 Jan 12;42(1):88-92. Epub 2019 Sep 12.

Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan. Electronic address:

Background: Multifocal motor neuropathy (MMN) is an acquired immune-mediated form of neuropathy characterized by upper and asymmetric limb weakness without sensory loss. The mean age of onset is 40 years (range, 20-70 years), and childhood-onset MMN is extremely rare. In the present report, we discuss a case of childhood-onset MMN in a patient who tested positive for anti-GM2 and anti-GalNac-GD1a immunoglobulin M (IgM) antibodies. Read More

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January 2020

Clinical and functional change in multifocal motor neuropathy treated with IVIg.

J Clin Neurosci 2019 Nov 12;69:114-119. Epub 2019 Aug 12.

Department of Neurology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia. Electronic address:

We determined the clinical progression, disability and outcome of 11 Multifocal Motor Neuropathy (MMN) patients from Malaysia. Mean patient age was 46.8 (SD 13. Read More

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November 2019

Motor conduction block and conduction velocity in Lewis-Sumner syndrome and multifocal motor neuropathy.

J Clin Neurosci 2019 Sep 1;67:10-13. Epub 2019 Jul 1.

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address:

Motor conduction blocks (CBs) and decreased motor nerve conduction velocity (MCV) are both demyelination electrophysiological characteristics. Though CBs are both common in Lewis-Sumner syndrome (LSS) and multifocal motor neuropathy (MMN), they are two distinct disease groups, so their MCV and CBs electrophysiological characteristics may be different. In this paper, we aimed to discuss the relationship between CBs and MCV in Lewis-Sumner syndrome (LSS) and multifocal motor neuropathy (MMN). Read More

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September 2019

Ultrasound in Multifocal Motor Neuropathy: Clinical and Electrophysiological Correlations.

J Clin Neuromuscul Dis 2019 Jun;20(4):165-172

Ellen & Martin Prosserman Centre for Neuromuscular Disorders, Toronto General Hospital, Toronto, ON, Canada.

Objectives: Multifocal motor neuropathy (MMN) is a treatable autoimmune polyneuropathy, which may prove challenging diagnostically in the setting of absent conduction blocks or advanced axonal loss. Relatively few studies have examined the role of ultrasound (US) in MMN.

Methods: Retrospective, cross-sectional study of patients with MMN who underwent peripheral nerve US. Read More

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Multifocal motor neuropathy in Austria: a nationwide survey of clinical features and response to treatment.

J Neurol 2018 Dec 26;265(12):2834-2840. Epub 2018 Sep 26.

Department of Neurology, KH Wels-Grieskirchen, Wels, Austria.

Background And Objectives: Multifocal motor neuropathy (MMN) is a rare neuropathy and detailed descriptions of larger patient cohorts are scarce. The objective of this study was to evaluate epidemiological, clinical, and laboratory features of MMN patients and their response to treatment in Austria and to compare these data with those from the literature.

Methods: Anonymized demographic and clinical data about MMN patients until 31. Read More

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December 2018

Multifocal motor neuropathy presenting as a post-infectious complication of dengue: a CASE report.

BMC Infect Dis 2018 Aug 22;18(1):415. Epub 2018 Aug 22.

National Hospital of Sri Lanka, Colombo, Sri Lanka.

Background: Dengue infection is an endemic illness in the tropics and it is associated with a wide variety of post infectious complications. With the increasing prevalence of dengue infection in endemic regions, post-infectious neurological complications following dengue infection are now been reported more frequently. We report a patient who developed multifocal motor neuropathy (MMN) with conduction blocks following dengue infection during the immediate post-infectious period. Read More

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A case of multifocal-motor-neuropathy-like disease with conduction blocks under infliximab with spontaneous progressive recovery.

Presse Med 2018 Mar 13;47(3):298-301. Epub 2018 Mar 13.

University Hospital of Pointe-à-Pitre, Rheumatology Unit, route de Chauvel, 97139 Abymes-Guadeloupe, France.

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Multifocal Motor Neuropathy Associated With Infliximab: A Case Report and a Literature Review.

Neurologist 2017 Jul;22(4):144-146

*Department of Neurology, Faculty of Medicine, Ondokuz Mayis University †Medicana Samsun Hospital, Rheumatology, Canik, Samsun, Turkey.

Multifocal motor neuropathy with conduction block (MMN-CB) is purely a motor neuropathy with progressive weakness that is characteristically caused by conduction blocks. Association with antiganglioside antibodies and a good response to immunomodulating therapies suggest an autoimmune etiology. In rare cases, MMN-CB has been reported as an adverse effect of infliximab, a tumor necrosis factor-α blocker. Read More

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Normalization of sonographical multifocal nerve enlargements in a MADSAM patient following a good clinical response to intravenous immunoglobulin.

Neuromuscul Disord 2016 09 14;26(9):619-23. Epub 2016 Jun 14.

Department of Neurology, Tenri Hospital, Tenri, Japan.

Focal nerve enlargements at sites of conduction blocks can be visualized sonographically in patients with multifocal acquired demyelinating sensory and motor neuropathy (MADSAM). However, little is known about association between nerve morphological changes and treatment responses. Here we present a 73-year-old female MADSAM patient whose sonographical multifocal nerve enlargements normalized following a good treatment response. Read More

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September 2016

[Multifocal motor neuropathy with conduction blocks].

Zh Nevrol Psikhiatr Im S S Korsakova 2016;116(6):70-72

Republican Clinical Hospital of Republic of Mari El, Yoshkar-Ola, Russia.

The article describes a case of multifocal motor neuropathy with conduction blocks in a female patient, aged 27 years. The development of the disease, results of neurological, laboratory, instrumental examinations, including electroneuromyography, and their role for the diagnosis and differential diagnosis are presented. Read More

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September 2018

Differential weakness of finger extensor muscles: A clinical pattern of multifocal motor neuropathy.

Muscle Nerve 2017 03 30;55(3):433-437. Epub 2016 Nov 30.

Department of Neurology, Hospital Universitari Son Espases, Carretera de Valldemossa, 79, 07120 Palma de Mallorca, Balearic Islands, Spain.

Introduction: Several studies have suggested that differential weakness in muscles supplied by the same motor nerve supports the diagnosis of multifocal motor neuropathy (MMN).

Methods: We describe the clinical, electrophysiological, neuroimaging, and laboratory findings of patients with a lower motor syndrome whose clinical presentation included differential finger extension weakness that we have seen in our neuromuscular clinic.

Results: We identified 3 patients with hand weakness and 1 patient with asymmetric weakness of the upper extremity. Read More

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[Clinical and electrophysiological characteristics and therapeutic analysis of 9 patients with Lewis-Sumner syndrome].

Zhonghua Yi Xue Za Zhi 2016 Mar;96(11):859-62

Department of Neurology, Peking University Third Hospital, Beijing 100191, China.

Objective: To investigate the clinical characteristics, electrophysiological findings and treatment response of Lewis-Sumner syndrome (LSS).

Methods: Data of nine patients with LSS, who were diagnosed and treated from May 2008 to August 2014 in Department of Neurology, Peking University Third Hospital, were analyzed retrospectively, including clinical features, electrophysiological studies, pathological characteristics, therapy and follow up.

Results: The nine cases included seven males and two females, with the average age being 29 years old (18-64 years old). Read More

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Nerve ultrasound in the differentiation of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis with predominant lower motor neuron disease (ALS/LMND).

J Neurol 2016 Jan;263(1):35-44

The objective of the study was to investigate nerve ultrasound (US) in comparison to nerve conduction studies (NCS) for differential diagnosis of amyotrophic lateral sclerosis with predominant lower motoneuron disease(ALS/LMND) and multifocal motor neuropathy(MMN). A single-center, prospective, examiner-blinded cross-sectional diagnostic study in two cohorts was carried out. Cohort I: convenience sample of subjects diagnosed with ALS/LMND or MMN (minimal diagnostic criteria:possible ALS (revised EL-Escorial criteria), possible MMN (European Federation of Neurosciences guidelines). Read More

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January 2016

The pathogenesis of multifocal motor neuropathy and an update on current management options.

Ther Adv Neurol Disord 2015 May;8(3):109-22

National Referral Center for rare Neuromuscular Diseases, Institut Hospitalo-Universitaire de Neurosciences, University Hospital Pitié-Salpêtrière and University Pierre et Marie Curie (Paris VI), Paris, France.

Multifocal motor neuropathy (MMN) is a rare and disabling disease. Several experimental studies and clinical data are strongly suggestive of an immune-mediated pathogenesis, although underlying mechanisms in MMN seem to be very specific, mainly because of the presence of IgM anti-GM1 serum antibodies and the dramatic response to intravenous immunoglobulins (IVIg). The origin of antiganglioside antibodies and the way in which they act at the molecular level remain unclear. Read More

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Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy.

Cochrane Database Syst Rev 2015 Mar 4(3):CD003217. Epub 2015 Mar 4.

Department of Neurology, National Neuroscience Institute, 11 Jalan Tan, Tock Seng, Singapore, Singapore, 308433.

Background: Multifocal motor neuropathy (MMN) is characterised by progressive, predominantly distal, asymmetrical limb weakness and usually multiple partial motor nerve conduction blocks. Intravenous immunoglobulin (IVIg) is beneficial but the role of immunosuppressive agents is uncertain. This is an update of a review first published in 2002 and previously updated in 2003, 2005, 2008 and 2011. Read More

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Nerve ultrasound for differentiation between amyotrophic lateral sclerosis and multifocal motor neuropathy.

J Neurol 2015 28;262(4):870-80. Epub 2015 Jan 28.

Department of Neurology, Neuromuscular Center, Basel University Hospital, University Basel, Petersgraben 4, 4000, Basel, Switzerland,

Ultrasound is useful for non-invasive visualization of focal nerve pathologies probably resulting from demyelination, remyelination, edema or inflammation. In patients with progressive muscle weakness, differentiation between multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis (ALS) is essential regarding therapy and prognosis. Therefore, the objective of this study was to investigate whether nerve ultrasound can differentiate between ALS and MMN. Read More

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January 2016

Nerve ultrasound in a case of multifocal motor neuropathy without conduction block.

Muscle Nerve 2015 Aug 30;52(2):294-9. Epub 2015 Jun 30.

Department of Neurology, St. Josef Hospital, Ruhr-University of Bochum, Gudrunstr. 56, 44791, Bochum, Germany.

Introduction: Multifocal nerve enlargements and ultrastructural changes either corresponding or not to sites of existing conduction blocks have been described in demyelinating polyneuropathies using multiple imaging techniques.

Methods: Using the emerging technique of peripheral nerve ultrasonography we investigated the peripheral nerves of a patient with multifocal motor neuropathy (MMN) without conduction block.

Results: In this case of MMN without conduction blocks we found multifocal nerve enlargements in the ultrasonography and electrodiagnostic signs of acute and chronic denervation associated with positive anti-GM1 IgM antibodies. Read More

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Multifocal-motor-neuropathy-like disease associated with Infliximab treatment in a patient with Crohn's disease.

J Neurol Sci 2015 Feb 9;349(1-2):246-8. Epub 2015 Jan 9.

Department of Neurophysiology, University Hospital of León, León, Spain.

Multifocal motor neuropathy is an immune-mediated disorder characterized by motor-conduction block in nerve-conduction studies. It is recognized that anti-TNF-α therapies are associated with immune-mediated conditions as adverse events. We report a case of multifocal-motor-neuropathy-like disease associated with the use of Infliximab in a patient with Crohn's disease. Read More

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February 2015

Diagnosis and treatment of chronic acquired demyelinating polyneuropathies.

Authors:
Norman Latov

Nat Rev Neurol 2014 Aug 1;10(8):435-46. Epub 2014 Jul 1.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 1305 York Avenue, Suite 217, New York, NY 10021, USA.

Chronic neuropathies are operationally classified as primarily demyelinating or axonal, on the basis of electrodiagnostic or pathological criteria. Demyelinating neuropathies are further classified as hereditary or acquired-this distinction is important, because the acquired neuropathies are immune-mediated and, thus, amenable to treatment. The acquired chronic demyelinating neuropathies include chronic inflammatory demyelinating polyneuropathy (CIDP), neuropathy associated with monoclonal IgM antibodies to myelin-associated glycoprotein (MAG; anti-MAG neuropathy), multifocal motor neuropathy (MMN), and POEMS syndrome. Read More

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Multifocal motor neuropathy with high titers of anti-MAG antibodies.

J Peripher Nerv Syst 2014 Jun;19(2):180-2

Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospital, Geneva, Switzerland.

Multifocal motor neuropathy (MMN) and anti-myelin-associated glycoprotein (anti-MAG)-associated neuropathy are clinically and electrophysiologically distinct entities. We describe a patient with characteristic features of both neuropathies, raising the possibility of an overlap syndrome. A 49-year-old patient reported a history of slowly progressive predominantly distal tetraparesis, with mild sensory deficits. Read More

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Treatment of multifocal motor neuropathy with intravenous immunoglobulin.

Authors:
Carol Lee Koski

J Clin Immunol 2014 Jul 5;34 Suppl 1:S127-31. Epub 2014 Apr 5.

GBS/CIDP Foundation International, 104 ½ Forrest Avenue, Narberth, PA, 19072, USA,

Multifocal motor neuropathy (MMN) is a rare inflammatory, chronically progressive, unremitting disorder affecting the peripheral nervous system. Although the etiology of this condition is not known, high titers of IgM Ab to GM1 may serve as a biomarker for this disease. Clinical findings of motor weakness are associated with focal conduction blocks and with time, axonal destruction. Read More

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Multifocal motor neuropathy.

Curr Opin Neurol 2013 Oct;26(5):503-9

National Referral Center for Rare Neuromuscular Diseases, Institut Hospitalo-Universitaire de Neurosciences, University Hospital Pitié-Salpêtrière, University Pierre et Marie Curie, Paris VI, Paris, France.

Purpose Of Review: Multifocal motor neuropathy (MMN) remains a difficult issue for neurologists, as its clinical and electrophysiological presentation may be atypical, and because no alternative treatment to periodic immunoglobulin infusions has been assessed in its long-term management. This review intends to summarize the most recent advances in the diagnosis and treatment of MMN.

Recent Findings: Recent reports have focused on atypical onset and unusual clinical presentation. Read More

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October 2013

Multifocal motor neuropathy.

Handb Clin Neurol 2013 ;115:429-42

Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA.

Multifocal motor neuropathy (MMN) is a rare disorder in which the symptoms are caused by persistent conduction block lesions. The mononeuropathy multiplex progresses over time with increasing axonal loss. The cause of the conduction blocks and axonal loss are not completely understood but immune mechanisms are involved and response to intravenous immunoglobulin has been established. Read More

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Multifocal motor neuropathy.

Presse Med 2013 Jun 25;42(6 Pt 2):e217-24. Epub 2013 Apr 25.

Hôpital de la Salpêtrière, Referral Center for Rare Neuromuscular Diseases, Bâtiment Babinski, Paris, France.

Multifocal motor neuropathy (MMN) is a chronic immune-mediated neuropathy that is particular for its asymmetric, multifocal, purely motor clinical presentation, often related to the distribution of individual nerves. Upper limbs are usually primarily and more severely affected, but lower limbs may be involved during the course of the disease. The hallmark of the disease is the presence, in electrophysiological studies, of persistent conduction blocks in the affected motor nerves, located outside the usual sites of nerve compression, contrasting with normal sensory nerve conduction velocities. Read More

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