Rheumatology (Oxford) 2017 Jun 14. Epub 2017 Jun 14.

Department of Internal Medicine, Maricopa Medical Center.

Cureus 2017 May 3;9(5):e1220. Epub 2017 May 3.

Rheumatology, Orlando VA Medical Center.

Multicentric reticulohistiocytosis (MRH) is an idiopathic multisystemic inflammatory disease characterized by symmetric erosive polyarthritis and typical papulonodular skin lesions. MRH can be associated with autoimmune diseases, malignancy, mycobacterial infections, and hyperlipidemia, and it is important to consider appropriate screening in this population. There is no specific diagnostic laboratory test for MRH. Read More

Int J Dermatol 2017 Aug 29;56(8):e173-e175. Epub 2017 May 29.

Department of Dermatology, Jichi Medical University, Shimotsuke, Japan.

J Eur Acad Dermatol Venereol 2017 Apr 6. Epub 2017 Apr 6.

Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Kliniczna 1a Street, 80-402, Gdańsk, Poland.

Australas J Dermatol 2017 Apr 4. Epub 2017 Apr 4.

Department of Dermatology, University General Hospital of Heraklion, Heraklion, Crete, Greece.

A 63-year-old Caucasian man presented with a 4-month history of disseminated asymptomatic reddish-brown papulonodular lesions. A skin biopsy showed dermal infiltration with CD68(+) histiocytes, predominantly with eosinophilic cytoplasm, some with a ground-glass cytoplasm, and a small number of giant cells. The diagnosis of multiple cutaneous reticulohistiocytosis was made. Read More

Clin Nucl Med 2017 Jul;42(7):567-568

From the Departments of *Nuclear Medicine, †Dermatology, and ‡Urology, National Center for Global Health and Medicine, Tokyo, Japan.

We report the case of a 75-year-old woman who underwent F-FDG PET/CT to evaluate the recurrence of urothelial carcinoma. PET/CT showed F-FDG-avid muscles and lymph nodes, mimicking recurrence. However, F-FDG uptake was also seen in multiple joints and subcutaneous tissue, representing an uncommon finding for recurrence. Read More

Best Pract Res Clin Rheumatol 2016 Apr 1;30(2):250-260. Epub 2016 Oct 1.

Department of Internal Medicine, Division of Rheumatology, Istanbul Faculty of Medicine, Istanbul, Turkey. Electronic address:

Multicentric reticulohistiocytosis (MRH) is a rare, multisystemic non-Langerhans cell histiocytosis characterized by skin and articular involvement, and rarely involves various other organs. There are no specific laboratory findings for MRH. Diagnosis is based on clinical findings and skin or synovial biopsy results. Read More

J Stroke Cerebrovasc Dis 2017 Jan 11;26(1):e22-e24. Epub 2016 Nov 11.

Department of Neurology, University of California, Los Angeles, California.

Multicentric reticulohistiocytosis (MRH) is a rare inflammatory disorder that presents with diverse systemic infiltrative manifestations. We report the first case of biopsy-proven MRH that presented with acute ischemic stroke in an embolic pattern. We discuss the clinical presentation, imaging findings, and diagnostic approach in our case. Read More

Am J Gastroenterol 2016 Sep;111(9):1227

Medical Faculty, University of Tuzla, Tuzla, Bosnia and Herzegovina.

J Pediatr 2016 Oct 1;177:328-328.e1. Epub 2016 Aug 1.

Department of Dermatology Section of Dermatopathology Medical College of Wisconsin Milwaukee, Wisconsin.

Clin Breast Cancer 2016 Dec 25;16(6):e203-e207. Epub 2016 Jun 25.

Neag Comprehensive Cancer Center, UConn Health, Farmington, CT.

J Clin Rheumatol 2016 Jun;22(4):220-1

From the *Servei de Reumatologia and †Servei de Dermatologia; and Hospital Moisès Broggi (CSI), Sant Joan Despí, Barcelona, Catalonia, Spain.

Pediatrics 2016 Jun;137(6)

Pediatrics, and.

Multicentric reticulohistiocytosis (MRH) is a rare histiocytic proliferative disorder of uncertain etiology, characterized by mucocutaneous papulonodular lesions and progressive, symmetric erosive arthritis. MRH can coexist with various autoimmune disorders, tuberculosis, and malignancy. It usually occurs in the elderly and is very rare in children. Read More

Semin Oncol 2016 Jun 23;43(3):341-6. Epub 2016 Feb 23.

University of Louisville Division of Dermatology, Louisville, KY. Electronic address:

The skin is often the herald of an underlying systemic illness, and gastrointestinal malignancies can present in numerous ways in the skin. Paraneoplastic phenomenon, such as acanthosis nigricans and tripe palm, may be the first indicator of a gastrointestinal malignancy. In addition, gastrointestinal cancers can metastasize to the skin, as described in the well-known Sister Mary Joseph's nodule. Read More

Semin Oncol 2016 Jun 23;43(3):331-4. Epub 2016 Feb 23.

Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC. Electronic address:

Breast cancer may present with cutaneous symptoms. The skin manifestations of breast cancer are varied. Some of the more common clinical presentations of metastatic cutaneous lesions from breast cancer will be described. Read More

Mol Med Rep 2016 Jul 12;14(1):209-17. Epub 2016 May 12.

Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

Multicentric reticulohistiocytosis (MRH) is a rare and debilitating systemic disorder characterized by cutaneous nodules and destructive polyarthritis. Due to its unknown etiology, the treatment of MRH varies with different rates of success, which causes treatment options to be rather independent and empirical. In the present study, a case of a 48‑year‑old woman with a 12‑month history of polyarthralgia and skin nodules was reported. Read More

Springerplus 2016 25;5:180. Epub 2016 Feb 25.

Department of Histopathology, AFIP (Armed Forces Institute of Pathology) , Rawalpindi, Pakistan.

Multicentric reticulohistiocytosis is a rare disease affecting skin and joints primarily and rarely other organs. We present a case report of this disease and an extensive review of the literature. We reviewed the data between 1991 and 2014 and extracted 52 individual cases. Read More

Indian J Dermatol 2016 Jan-Feb;61(1):121

Department of Dermatology, Mahatma Gandhi Mission Hospital, Navi Mumbai, Maharashtra, India.

Multicentric reticulohistiocytosis is a rare non-Langerhans cell histiocytosis characterized in its full form by severe destructive arthritis, cutaneous nodules, and systemic manifestations. Cutaneous lesions may precede, accompany, or more commonly develop later than other features in this disease. We describe a case of multiple cutaneous reticulohistiocytoma without any systemic associations after thorough investigations. Read More

Am J Clin Pathol 2016 Feb 23;145(2):211-21. Epub 2016 Jan 23.

From the Departments of Pathology and.

Objectives: To describe the radiologic and clinicopathologic features of extranodal Rosai-Dorfman disease (RDD) in our patient population.

Methods: Via a data mining engine, we evaluated 13 cases of extranodal RDD in 10 patients treated at our institution from 2000 to 2014.

Results: There was a marked female predominance (90%) in our series. Read More

Dermatology 2016 8;232(2):171-6. Epub 2016 Jan 8.

Departamento de Neurologx00ED;a, Clx00ED;nica Las Condes, Santiago, Chile.

A young male presented with panhypopituitarism (including diabetes insipidus) and temporal lobe epilepsy. A histology specimen of cutaneous papules was diagnostic of non-Langerhans histiocytosis. The diagnosis of xanthoma granulomata was considered based on the clinical and brain MRI findings. Read More

Respirol Case Rep 2015 Dec 15;3(4):125-7. Epub 2015 Sep 15.

Department of Respiratory Medicine Iwata City Hospital Iwata Japan.

Organizing pneumonia (OP) is a clinicopathological entity that occurs idiopathically or in association with several conditions such as connective tissue diseases. Multicentric reticulohistiocytosis (MRH) is a systemic disease characterized by polyarthritis and mucocutaneous lesions, but lung involvement is uncommon. We report a patient with MRH associated with OP. Read More

Int J Hematol 2016 Apr 21;103(4):469-72. Epub 2015 Dec 21.

Section of Clinical Immunology, Department of Internal Medicine, Erasmus University MC, University Medical Center, Room D-419, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.

Human herpes virus 8 (HHV-8)-associated secondary hemophagocytic lymphohistiocytosis is a rare but critical immuno-hematological entity in immunocompetent patients. Establishing a diagnosis is challenging as is the monitoring of disease activity and therapeutic effects. We report a case of a HHV-8-associated hemophagocytic lymphohistiocytosis in a HIV-negative adult patient with multicentric Castleman's disease. Read More

Scand J Rheumatol 2016 14;45(3):247-9. Epub 2015 Dec 14.

a Department of Rheumatology , Hiroshima City Hiroshima Citizens Hospital , Hiroshima , Japan.

Clin Orthop Surg 2015 Dec 13;7(4):509-14. Epub 2015 Nov 13.

Department of Pathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Multicentric reticulohistiocytosis (MRH) is a rare systemic disease, which commonly manifests as muco-cutaneous papulonodules and inflammatory erosive polyarthropathy. In this research, we report the clinical manifestations and management of a rare case of MRH with destructive arthropathy of bilateral hip joints and arthritis mutilans presenting with characteristic deformities. Disabling hip arthropathy that occurs secondary to MRH can be successfully managed with bilateral total hip arthroplasty (THA). Read More

Clin Nucl Med 2016 Apr;41(4):333-5

From the Departments of *Nuclear Medicine, and †Dermatology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Multicentric reticulohistiocytosis is a rare systemic inflammatory disease of unknown etiology characterized by the infiltration of histiocytes and multinucleated giant cells into multiple systems. The definitive diagnosis depends on biopsy of the affected tissues. Here, we report the F-FDG PET/CT findings of a 62-year-old man with multicentric reticulohistiocytosis. Read More

Dermatol Clin 2015 Jul;33(3):465-72; discussion 473

Department of Dermatology, UCSF, 1701 Divisadero Street, San Francisco, CA 94115, USA. Electronic address:

Adult xanthogranuloma presents most commonly as an orange-tan firm solitary nodule with no systemic manifestations. Recently, some cases have been reported in conjunction with lymphoproliferative disorders. Adult reticulohistiocytosis classically presents as red to yellow-red dermal nodules. Read More

Transplantation 2016 Jan;100(1):134-40

1 Institute of Pathology, University Hospital (CHUV), Lausanne, Switzerland. 2 Institute of Microbiology, University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland. 3 Infectious Diseases Service, University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland. 4 Transplantation Center, University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.

Kaposi sarcoma is the most common human herpesvirus 8 (HHV-8)-related disease described after solid organ transplantation. Multicentric Castleman disease and hemophagocytic syndrome are other potential HHV-8-induced entities but are less frequently reported. We describe the case of a liver transplant recipient who presented with an acute febrile illness 1 year after transplantation with a rapidly fatal outcome. Read More

Acta Derm Venereol 2016 Jan;96(1):124-5

Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.

Int J Clin Exp Pathol 2015 1;8(3):3304-7. Epub 2015 Mar 1.

Hubei Huanggang Central Hospital Huanggang 438000, Hubei Province, China.

We report a rare case of multicentric reticulohistiocytosis (MRH) associated with liver carcinoma. A 36-year-old man who had been diagnosed as having liver carcinoma for 2 years presented with a 2-month history of multiple papulonodules on the face, ears, neck, and upper chest, accompanied by progressive polyarthralgia of the hands, wrists, elbows and knee joints without fever or chills. Skin histology revealed well defined dermal infiltrate consisting of multinucleated giant cells and macrophages having abundant eosinophilic finely granular cytoplasm with ground glass appearance. Read More

Curr Rheumatol Rep 2015 Jun;17(6):511

BIOMETRA Department, University of Milan, Milan, Italy.

The literature reports approximately 300 cases of multicentric reticulohistiocytosis (MRH) worldwide, mostly women of Caucasian origin. MRH manifests as a symmetric erosive polyarthritis mimicking rheumatoid arthritis with the subsequent appearance of typical papulonodular skin lesions. The disease may rapidly progress towards mutilans arthritis in the majority of cases, but it generally remits spontaneously in 10 years. Read More

Med Clin (Barc) 2015 Dec 4;145(11):508-9. Epub 2015 Apr 4.

Servicio de Reumatología, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid, España.

Joint Bone Spine 2015 Jul 13;82(4):280-3. Epub 2015 Mar 13.

Department of Internal Medicine, université Paris VI, hôpital Tenon, département hospitalo-universitaire I2B, Assistance Publique-Hôpitaux de Paris, 75020 Paris, France.

Multicentric reticulohistyocytosis (MRH) is a rare multisystemic non-Langerhans histiocytosis characterized by cutaneous nodules and severe destructive polyarthritis, sometimes associated with constitutional symptoms and various organ involvements. Its treatment remains empirical and challenging. We first report herein, the successful treatment of a multicentric reticulohistiocytosis patient with anakinra based on cutaneous biopsy immunostaining and serum cytokines features. Read More

Case Rep Dermatol 2015 Jan-Apr;7(1):7-9. Epub 2015 Jan 16.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Reticulohistiocytoma (RH) is a dermal histiocytic infiltration composed of large histiocytes with eosinophilic glassy cytoplasm. RH is classified into three clinical forms: solitary RH, diffuse cutaneous RH without systemic involvement and multicentric reticulohistiocytosis with systemic diseases. Solitary RH generally manifests as a nodular lesion in adults without accompanying systemic diseases. Read More

Pediatr Dermatol 2015 May-Jun;32(3):e70-3. Epub 2015 Feb 26.

Department of Pediatrics, Oregon Health and Science University, Portland, Oregon.

Multicentric reticulohistiocytosis (MRH) is a rare systemic inflammatory granulomatous disease marked by severe and often rapidly progressive polyarticular arthritis and cutaneous papulonodules. Initial clinical diagnosis may be difficult. We describe a 2-year-old girl presenting with pink dermal papules on the forehead, thighs, elbows, knees, and palms of the hands. Read More

Pediatr Dermatol 2015 Jan-Feb;32(1):e1-4. Epub 2014 Dec 14.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Xanthoma disseminatum (XD) is a rare, benign, non-Langerhans cell histiocytosis characterized by disseminated xanthomatous lesions with a predilection for the face, flexures, and mucosae. Approximately 100 cases have been reported in the literature. We report XD in an 8-year-old boy with symmetric synovitis and arthritis involving the wrists and knees. Read More

Mod Rheumatol 2017 Jan 11;27(1):165-168. Epub 2014 Sep 11.

a Division of Rheumatology, Department of Internal Medicine , College of Medicine, The Catholic University of Korea , Seoul , Republic of Korea.

Multicentric reticulohistiocytosis (MRH) is a rare non-Langerhans histiocytosis of unknown etiology with a predilection for joint and skin. The characteristic clinical features are papulonodular skin eruptions and inflammatory polyarthritis, sometimes progressive to arthritis mutilans, a severe destructive arthropathy. Although these manifestations can present at the same time, it is more common that one feature precedes the others. Read More

Mayo Clin Proc 2014 Aug;89(8):e73

School of Psychiatry and Neurosciences, University of Western Australia, Nedlands, Western Australia, Australia.

Int J Dermatol 2015 Jun 11;54(6):e222-5. Epub 2014 Jul 11.

Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea.

Cutis 2014 May;93(5):243-6

Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, 111 E 210th St, Bronx, NY 10467, USA.

Multicentric reticulohistiocytosis (MR) is a rare debilitating disease that involves the skin and joints. It most commonly affects white individuals but has been reported in other ethnic groups including black individuals, Native Americans, and Asians. The Hispanic population is largely underrepresented in the epidemiology of MR. Read More

Clin Rheumatol 2016 Feb 15;35(2):527-34. Epub 2014 Apr 15.

Rheumatology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Multicentric reticulohistiocytosis (MRH) is a rare systemic and devastating disease with main involvement of skin and joints, frequently related with malignancies. Macrophages and TNFα are the main targets of multiple treatment options with variable results. Although MRH has the tendency of self-resolve in an average of 8 years, treatment must be started early to avoid sequelae, mainly in joints with severe deformities and daily life activity impairment. Read More

J Rheumatol 2014 Apr;41(4):780-1

Assistant Professor of Medicine;

Indian Dermatol Online J 2014 Jan;5(1):74-6

Department of Dermatology and Venereology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Multiple cutaneous reticulohistiocytoma (MCR) and multicentric reticulohistiocytosis (MR) are rare, idiopathic histiocytic granulomatous disorders presenting in a spectrum. A 35-year-old female presented with multiple, firm, discrete, asymptomatic nodules, 1-2 cm in size over face, back, abdomen, thighs, and legs. There were no systemic symptoms. Read More

Dermatol Online J 2013 Nov 15;19(11):20400. Epub 2013 Nov 15.

Baylor College of Medicine.

We describe a patient with granuloma annulare (GA) who presented with firm periungual papules mimicking "coral beads", a characteristic sign of multicentric reticulohistiocytosis (MRH). We highlight the importance of distinguishing between GA and MRH because the prognoses differ significantly. Read More

Eur J Med Res 2013 Oct 29;18:38. Epub 2013 Oct 29.

The Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.

Multicentric reticulohistiocytosis (MRH) is a very rare systemic disease with variable phenotypic presentation and a high rate of misdiagnosis. Here we describe a patient with MRH and extra-mammillary Paget's disease (EMPD), a diagnosis that has not previously been described in the literature. Read More

J Cutan Aesthet Surg 2013 Jul;6(3):161-3

Department of Dermatology, Sumandeep Vidhyapeeth, Piparia, Vadodara, Gujarat, India.

The carbon dioxide (CO2) laser is a versatile tool that has applications in ablative lasing and caters to the needs of routine dermatological practice as well as the esthetic, cosmetic, and rejuvenation segments. We report a case of multicentric reticulohistiocytosis with cosmetically disfiguring confluent papules over the scalp, forehead, nasolabial folds, chin, and retroauricular region. We used CO2 laser in superpulse mode for ablating the lesions in three sittings. Read More

J Eur Acad Dermatol Venereol 2014 Jun 24;28(6):679-88. Epub 2013 Aug 24.

Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy.

Skin and joint manifestations are part of the clinical spectrum of many disorders. Well-known associations include psoriatic arthritis and arthritis associated with autoimmune connective tissue diseases. This review focuses on less common associations where skin lesions can provide easily accessible and valuable diagnostic clues, and directly lead to the specific diagnosis or limit the list of possibilities. Read More

J Vet Med Sci 2014 Jan 23;76(1):89-92. Epub 2013 Aug 23.

Fukushima Meat Hygiene Inspection Office, 38-6 Kitasawada, Senouemachi, Fukushima-shi, Fukushima 960-0101, Japan.

Gross lesions characterized by swollen livers and spleens accompanied by diffuse white miliary spots, which resembled those of Marek's disease, were detected in two flocks of local meat-type chickens at a Japanese poultry processing plant in June and August 2010. The microscopic examinations revealed proliferative foci consisting of spindle or polymorphic cells in the interstitium of livers, splenic follicles and the interstitium of kidneys. These cells were positive immunohistochemically with Iba1 antibody, indicating they were histiocytic cells. Read More

J Clin Rheumatol 2013 Aug;19(5):272-6

Facultad de Medicina, Universidad Autónoma de Chihuahua, Circuito Universitario Campus II, Chihuahua, Mexico.

Multicentric reticulohistiocytosis (MRH) is a rare multisystem, granulomatous debilitating disease. It affects the skin with a nodular diffuse dermatitis and the joints with a severe, potentially deforming, and handicapping arthritis. No standardized therapy exists, it is a disease with heterogeneous severity, and therefore, a diversity of therapeutic responses has been published. Read More

Int J Surg Case Rep 2013 22;4(8):744-7. Epub 2013 May 22.

Norfolk and Norwich University Hospital NHS Foundation Trust, NR4 7UY, UK.

Introduction: Multicentric Reticulohistiocytosis (MRH) is a rare non-Langerhans cell histiocytosis characterised by destructive polyarthritis and violaceous skin papules.

Presentation Of Case: In 2010, a 70-year-old woman with Palindromic Rheumatism was diagnosed with MRH. Within a few months, she developed ankylosis of the small joints of both hands which resulted in severe fixed flexion deformities of the fingers and thumbs. Read More

J Comp Pathol 2013 Aug-Oct;149(2-3):385-9. Epub 2013 Apr 10.

Department of Pathology, Microbiology and Immunology, University of California at Davis, Davis, CA, USA.

A wild caught juvenile male raccoon with neurological disease was humanely destroyed due to poor prognosis. Necropsy examination revealed hepatomegaly, splenomegaly and multicentric lymphadenomegaly with diffuse hepatic pallor and pulmonary consolidation with pinpoint pale subpleural foci. Microscopically, there was marked pale cytoplasmic swelling of the central and peripheral neurons as well as the glial cells in the brain, accompanied by multiorgan infiltration by abundant foamy macrophages. Read More