11,573 results match your criteria Multicentric Reticulohistiocytosis


[Training in Family Health and its association with work processes of Primary Care Dentistry Teams].

Cien Saude Colet 2018 Dec;23(12):4319-4329

Departamento de Odontologia Preventiva e Social, Faculdade de Odontologia, UFRGS. Porto Alegre RS Brasil.

The National Oral Health Policy emphasizes the importance of training in Primary Health Care and adapting the work processes to the new health care model. This study seeks to investigate the association between the training of Dental-Surgeons in Family Health and the work process. It involved a cross-sectional and multicentric study, with 18,114 Oral Health Teams that participated on the National Program to Enhance Access and Quality of Primary Health Care. Read More

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December 2018

Survival Impact of Locoregional Treatment of the Primary Tumor in De Novo Metastatic Breast Cancers in a Large Multicentric Cohort Study: A Propensity Score-Matched Analysis.

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Medical Oncology, Claudius Regaud Institute, IUCT-Oncopole, Toulouse Cedex 09, France.

Introduction: Improvement in overall survival (OS) by locoregional treatment (LRT) of the primary tumor in de novo metastatic breast cancer (MBC) patients remains controversial.

Objective: The aim of our study was to evaluate the impact of LRT on OS in a large retrospective cohort of de novo MBC patients, with regard to immunohistochemical characteristics and pattern of metastatic dissemination.

Methods: We conducted a multicentric retrospective study of patients diagnosed with de novo MBC selected from the French Epidemiological Strategy and Medical Economics MBC database (NCT03275311) between 2008 and 2014. Read More

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December 2018

Laterally Extended Pelvic Resection for Gynaecological Malignancies: A Multicentric Experience with Out-of-the-Box Surgery.

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Gynaecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University in Prague, General University Hospital in Prague, Prague, Czech Republic.

Purpose: To evaluate morbidity and oncological outcome in a multicentre series of women with gynaecological malignancies infiltrating pelvic side wall (PSW) that received laterally extended pelvic resection (LEPR).

Methods: Patients operated between 2007 and 2017 at three institutions were included. LEPR was defined as an en bloc lateral resection of a pelvic tumour involving sidewall muscle, and/or bone, and/or major nerve, and/or major vascular structure. Read More

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December 2018

TVT versus TOT in the treatment of female stress urinary incontinence: a systematic review and meta-analysis.

Ther Clin Risk Manag 2018 20;14:2293-2303. Epub 2018 Nov 20.

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China,

Background: To evaluate the evidence available on the effects and safety of tension-free vaginal tape (TVT) versus transobturator tape (TOT) for female stress urinary incontinence therapy based on randomized controlled trials (RCTs).

Methods: PubMed, Cochrane, Embase, Wanfang, China National Knowledge Infrastructure, and Weipu database were searched up to July 2017 to identify relevant studies, including qualified RCT and quite-RCT and literature sources. Relative risks (RRs), mean difference (MD), and 95% CI were calculated in our review. Read More

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November 2018

Tel-eVax: a genetic vaccine targeting telomerase for treatment of canine lymphoma.

J Transl Med 2018 Dec 11;16(1):349. Epub 2018 Dec 11.

BIOGEM Scarl, via Camporeale, 83031, Ariano Irpino, AV, Italy.

Background: we have recently shown that Tel-eVax, a genetic vaccine targeting dog telomerase (dTERT) and based on Adenovirus (Ad)/DNA Electro-Gene-Transfer (DNA-EGT) technology can induce strong immune response and increase overall survival (OS) of dogs affected by multicentric Diffuse Large B cell Lymphoma (DLBCL) when combined to COP therapy in a double-arm study. Here, we have utilized a clinically validated device for veterinary electroporation called Vet-ePorator™, based on Cliniporator™ technology currently utilized and approved in Europe for electrochemotherapy applications and adapted to electrogenetransfer (EGT).

Methods: 17 dogs affected by DLBCL were vaccinated using two Ad vector injections (Prime phase) followed by DNA-EGT (Boost phase) by means of a Vet-ePorator™ device and treated in the same time with a 27-week Madison Wisconsin CHOP protocol. Read More

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December 2018

External validation of a combined PET and MRI radiomics model for prediction of recurrence in cervical cancer patients treated with chemoradiotherapy.

Eur J Nucl Med Mol Imaging 2018 Dec 7. Epub 2018 Dec 7.

Radiation Oncology Department, University Hospital, Brest, France.

Purpose: The aim of this study was to validate previously developed radiomics models relying on just two radiomics features from F-fluorodeoxyglucose positron emission tomography (PET) and magnetic resonance imaging (MRI) images for prediction of disease free survival (DFS) and locoregional control (LRC) in locally advanced cervical cancer (LACC).

Methods: Patients with LACC receiving chemoradiotherapy were enrolled in two French and one Canadian center. Pre-treatment imaging was performed for each patient. Read More

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December 2018

Baseline multicentric tumors, distant recurrences and leptomeningeal dissemination predict poor survival in patients with recurrent glioblastomas receiving bevacizumab.

J Neurooncol 2018 Dec 10. Epub 2018 Dec 10.

Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Purpose: There are no widely accepted MRI markers that predict treatment outcomes of bevacizumab among patients with recurrent glioblastoma (GB). We aimed to determine if conventional MRI features of recurrent GB predict survival of patients receiving bevacizumab.

Methods: Patients with recurrent GB were retrospectively included if they received bevacizumab monotherapy between 2008 and 2017 after failure of standard treatment. Read More

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December 2018

New Approach to Oncoplastic Breast Conservation: Combining Autologous Volume Replacement and the Wise-pattern Mammaplasty.

Plast Reconstr Surg Glob Open 2018 Oct 16;6(10):e1987. Epub 2018 Oct 16.

Georgia Breast Surgery, Lawrenceville, Ga.

Background: Oncoplastic breast-conserving surgery describes a set of techniques that allow for generous oncological resection with immediate tumor-specific reconstruction. These techniques are classically divided into either volume displacement (local breast flaps and or reduction mammaplasty/mastopexy strategies) versus volume replacement strategies (transfer of autologous nonbreast tissue from a local or distant site and, less commonly, implant placement). There have been few descriptions of merging these 2 classical approaches to facilitate breast-conserving surgery. Read More

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October 2018

Polymorphisms in KSHV-encoded microRNA sequences affect levels of mature viral microRNA in Kaposi Sarcoma lesions.

Oncotarget 2018 Nov 9;9(88):35856-35869. Epub 2018 Nov 9.

AIDS and Cancer Virus Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

Background: We previously reported Kaposi sarcoma-associated herpesvirus (KSHV) microRNA sequence variants in clinical samples correlated with increased risk of multicentric Castleman's disease (MCD). We then demonstrated that microRNAs with variant sequence have different maturation and mature microRNA expression . Here, we illustrate the association between microRNA sequence and changes in mature microRNA levels within Kaposi sarcoma (KS) lesions. Read More

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November 2018

[Thrombotic microangiopathy developing subsequent to tocilizumab therapy in a patient with TAFRO syndrome].

Rinsho Ketsueki 2018 ;59(11):2432-2437

Department of Pathology, Hakodate Municipal Hospital.

We report a case of a 60-year-old male who presented with fever and anasarca as well as hepatosplenomegaly, general lymphadenopathy, and disseminated intravascular coagulation (DIC), and was, therefore, admitted to our hospital. In addition, the patient suffered from respiratory failure and renal dysfunction and had pleural effusion and ascites. The pathological diagnosis from lymph node biopsy suggested multicentric Castleman's disease of the plasma cell type; however, the presence of high IL-6 levels, myelofibrosis, thrombocytopenia, anasarca, renal dysfunction, and hepatosplenomegaly led to a definitive diagnosis of TAFRO syndrome. Read More

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January 2018

Salivary gland tumors in a Brazilian population: A 20-year retrospective and multicentric study of 2292 cases.

J Craniomaxillofac Surg 2018 Sep 26. Epub 2018 Sep 26.

Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte-UFRN, Av. Senador Salgado Filho, 1787-Lagoa Nova, Natal, RN, 59056-000, Brazil. Electronic address:

Purpose: Neoplasms of the salivary glands comprise more than thirty subtypes of lesions with various clinical behaviors. The present study aimed to describe the incidence and main features of salivary gland tumors in Brazil.

Material And Methods: A retrospective descriptive cross-sectional study was performed (1997-2017). Read More

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September 2018

[Preliminary multicentric study on the nutritional status in hospitalization at home (HaD) with the same informational application of nutritional assessment].

Nutr Hosp 2018 Dec 3;35(6):1340-1346. Epub 2018 Dec 3.

Hospital Universitario Arnau de Vilanova de Lleida.

Introduction: the prevalence of hospital malnutrition is high and involves an increase in health care costs. Home hospitalization (HH) allows better clinically stable patient control after an acute illness by a highly specialized health care team.

Objective: to know the nutritional condition of home hospitalization patients using a computer application that allows the implementation of early nutritional measures at home and improves post-hospital control of these patients. Read More

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December 2018

Prevalence of Human Papillomavirus, HIV and other sexually transmitted infections among men having sex with men in Togo: a national cross-sectional survey.

Clin Infect Dis 2018 Dec 6. Epub 2018 Dec 6.

Université de Lomé, Faculté des Sciences de la Santé, Département de Santé Publique, Lomé, Togo.

Background: Sub-Saharan Africa is a region of both high HIV and anal cancer incidence. We conducted the first national study in Togo to assess HPV, HIV and other Sexually Transmitted Infections (STIs) prevalence among Men having Sex with Men (MSM).

Methods: A multicentric cross-sectional study was conducted among MSM recruited in four Togolese cities based on the respondent-driven sampling method. Read More

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December 2018

Just how much does it cost? A cost study of chronic pain following cardiac surgery.

J Pain Res 2018 8;11:2741-2759. Epub 2018 Nov 8.

Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada,

Objective: The study objective was to determine use of pain-related health care resources and associated direct and indirect costs over a two-year period in cardiac surgery patients who developed chronic post-surgical pain (CPSP).

Methods: This multicentric observational prospective study recruited patients prior to cardiac surgery; these patients completed research assistant-administered questionnaires on pain and psychological characteristics at 6, 12 and 24 months post-operatively. Patients reporting CPSP also completed a one-month pain care record (PCR) (self-report diary) at each follow-up. Read More

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November 2018

Acral and Multicentric Pigmented Bowen's Disease in HIV-Positive Patients: Report on Two Unusual Cases.

Indian J Dermatol 2018 Nov-Dec;63(6):506-508

Centro De Investigación En Enfermedades Infecciosas, Instituto Nacional De Enfermedades Respiratorias, Ismael Cosío Villegas, México City, México.

squamous cell carcinoma of the skin (SCCis or Bowen's disease) is a common intraepidermal cutaneous malignancy with a low invasive potential. Acral Bowen's disease is usually solitary, but multiple acral SCCis have been reported. Pigmented Bowen's disease is typically unilesional and characterized by a hyperpigmented plaque with a velvety of keratotic surface, which can eventually simulate melanoma clinically. Read More

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December 2018
1 Read

Novel insights and therapeutic approaches in idiopathic multicentric Castleman disease.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):318-325

Division of Translational Medicine & Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Castleman disease (CD) describes a heterogeneous group of hematologic disorders that share characteristic lymph node histopathology. Patients of all ages present with either a solitary enlarged lymph node (unicentric CD) or multicentric lymphadenopathy (MCD) with systemic inflammation, cytopenias, and life-threatening multiple organ dysfunction resulting from a cytokine storm often driven by interleukin 6 (IL-6). Uncontrolled human herpesvirus-8 (HHV-8) infection causes approximately 50% of MCD cases, whereas the etiology is unknown in the remaining HHV-8-negative/idiopathic MCD cases (iMCD). Read More

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November 2018
1 Read

Cerclage wiring and intramedullary nailing, a helpful and safe option specially in proximal fractures. A multicentric study.

Injury 2018 Nov 24. Epub 2018 Nov 24.

Servicio de Traumatologia y Cirugia Ortopedica, Complexo Hospitalario Universitario de Santiago de Compostela, Spain; Musculoskeletal Pathology Group, Institute IDIS, Lab 18, Spain.

Purpose: Antegrade intramedullary nailing is an alternative for humeral shaft fracture treatment. This surgical technique can be especially demanding in some fracture patterns, leading to problems like malunion and non-union. The purpose of our study is to demonstrate that the use of a nail with cerclage wires could be a safe procedure that facilitate reduction, specially in fractures with abduction of the proximal fragment. Read More

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November 2018
1 Read

Type 2 endoleak incidence and fate after EVAR in a multicentric series: different results with different devices?

Ann Vasc Surg 2018 Nov 28. Epub 2018 Nov 28.

Vascular and Endovascular Surgery Unit, Deprtment of Surgery "P Stefanini", Policlinico "Umberto I", "Sapienza" University of Rome.

Objectives: Aim of this work is describing incidence and fate of type 2 endoleaks (T2EL) in a multi-centric cohort of patients treated by EVAR with Ovation device (Endologix), and compering them with a group treated by Excluder (W.L. Gore & Associates). Read More

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November 2018
1 Read

Aggressive Squamous Cell Carcinoma in Organ Transplant Recipients.

JAMA Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Importance: Squamous cell carcinoma (SCC) is the most frequent malignant neoplasm found in solid organ transplant recipients and is associated with a more aggressive disease course and higher risk of metastasis and death than in the general population.

Objectives: To report the clinicopathologic features of and identify factors associated with aggressive SCC in solid organ transplant recipients.

Methods: This retrospective multicentric case series included 51 patients who underwent solid organ transplantation and were found to have aggressive SCC, defined by nodal or distant metastasis or death by local progression of primary SCC. Read More

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December 2018
4 Reads

The lymph node status as a prognostic factor in colon cancer: comparative population study of classifications using the logarithm of the ratio between metastatic and nonmetastatic nodes (LODDS) versus the pN-TNM classification and ganglion ratio systems.

BMC Cancer 2018 Dec 4;18(1):1208. Epub 2018 Dec 4.

Department of Surgery, Hospital General de Castellón, Av. Benicassim s/n, 12004, Castellón, Spain.

Background: pN stage in the TNM classification has been the "gold standard" for lymph node staging of colorectal carcinomas, but this system recommends collecting at least 12 lymph nodes for the staging to be reliable. However, new prognostic staging systems have been devised, such as the ganglion quotients or lymph node ratios and natural logarithms of the lymph node odds methods. The aim of this study was to establish and validate the predictive and prognostic ability of the lymph node ratios and natural logarithms of the lymph node odds staging systems and to compare them to the pN nodal classification of the TNM system in a population sample of patients with colon cancer. Read More

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December 2018
1 Read

Mass spectrometry based analytical quality assessment of serum and plasma specimens with patterns of endo- and exogenous peptides.

Clin Chem Lab Med 2018 Dec 4. Epub 2018 Dec 4.

Institute for Clinical Chemistry, Mannheim Medical Faculty of Heidelberg University, University Hospital Mannheim, Mannheim, Germany.

Background Inappropriate preanalytical sample handling is a major threat for any biomarker discovery approach. Blood specimens have a genuine proteolytic activity that leads to a time dependent decay of peptidic quality control markers (QCMs). The aim of this study was to identify QCMs for direct assessment of sample quality (DASQ) of serum and plasma specimens. Read More

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December 2018
3 Reads

A Survey on Pituitary Surgery In Italy.

World Neurosurg 2018 Nov 27. Epub 2018 Nov 27.

Division of Neurosurgery, Università degli Studi di Napoli "Federico II", Napoli, Italy.

Background: Pituitary tumors are a heterogeneous group of lesions that are usually benign. Therefore, proper understanding of the anatomy, physiology and pathology is mandatory to achieve a favorable outcome. Accordingly, diagnostics and treatment guidelines need to be determined and implemented. Read More

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November 2018
1 Read

[Unilateral multifocal uveal melanoma (a clinical and genetic study)].

Vestn Oftalmol 2018 ;134(5):78-85

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315.

The study presents clinical and genetic analysis of a case of unilateral multifocal uveal choroidal melanoma in a patient of 67 years. Results of ophthalmoscopy, echography, fluorescent angiography, optical coherence tomography are described. Molecular genetic testing of peripheral blood samples was performed, including detection of the occurrences of CC genotype in C3435T polymorphism of the gene ABCB1/MDR1 associated with unfavorable vital prognosis. Read More

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January 2018
3 Reads

Predictors of recurrence after surgical treatment of idiopathic progressive subglottic stenosis.

Acta Otorhinolaryngol Ital 2018 Oct;38(5):417-423

Department of Otorhinolaryngology Head and Neck Surgery, Klinikum Stuttgart, Germany.

Idiopathic progressive subglottic stenosis is a rare cause of tracheal narrowing. Partial cricotracheal resection and anastomosis can cure idiopathic stenosis, even if some patients may require multiple interventions and experience voice and swallowing deterioration. We investigated risk factors for retreatment and assessed the impact of crico-tracheal resection on functional parameters. Read More

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October 2018
2 Reads

Musculoskeletal manifestations in pediatric patients infected with human immunodeficiency virus: Developing country perspective.

Eur J Rheumatol 2018 Oct 12. Epub 2018 Oct 12.

Department of Pediatric Medicine, Kolkata Medical College, Kolkata, India.

Objective: Musculoskeletal manifestations in children infected with human immunodeficiency virus (HIV) are responsible for increased morbidity and decreased quality of life. Even in this era of highly active anti-retroviral therapy (HAART), there are limited studies on different rheumatological manifestations in pediatric patients with HIV, and the spectrum of musculoskeletal manifestation in pediatric HIV is yet to be established.

Methods: A single-center, prospective, observational study was carried out from October 2014 to September 2016 in a tertiary care hospital of Eastern India with 517 children infected with HIV aged between 3 and 19 years. Read More

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October 2018

Novel insights and therapeutic approaches in idiopathic multicentric Castleman disease.

Blood 2018 Nov;132(22):2323-2330

Division of Translational Medicine & Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Castleman disease (CD) describes a heterogeneous group of hematologic disorders that share characteristic lymph node histopathology. Patients of all ages present with either a solitary enlarged lymph node (unicentric CD) or multicentric lymphadenopathy (MCD) with systemic inflammation, cytopenias, and life-threatening multiple organ dysfunction resulting from a cytokine storm often driven by interleukin 6 (IL-6). Uncontrolled human herpesvirus-8 (HHV-8) infection causes approximately 50% of MCD cases, whereas the etiology is unknown in the remaining HHV-8-negative/idiopathic MCD cases (iMCD). Read More

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November 2018
1 Read

Severe warm-antibody autoimmune hemolytic anemia due to multicentric Castleman disease: Responding to rituximab.

J Oncol Pharm Pract 2018 Nov 28:1078155218816775. Epub 2018 Nov 28.

2 Eisenhower Lucy Curci Cancer Center, Rancho Mirage, CA, USA.

Castleman disease is a rare B-cell lymphoproliferative disorder characterized by lymph node enlargement with or without constitutional signs. Herein, we describe a unique patient with multicentric Castleman disease and retroviral infection who presented with a sudden onset of constitutional signs and was found to have severe warm-antibody autoimmune hemolytic anemia. Rituximab monotherapy yielded an excellent clinical response. Read More

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November 2018
1 Read

Corneoconjunctival manifestations of lymphoma in three dogs.

J Vet Sci 2018 Nov 26. Epub 2018 Nov 26.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.

An 8-year-old Shih Tzu, a 5-year-old Maltese, and a 10-year-old Maltese presented with conjunctival hyperemia and peripheral corneal edema. Severe conjunctival thickening with varying degrees of corneal extension were observed. Cytological examination showed many large lymphocytes with malignant changes in the conjunctiva and were consistent with findings in fine-needle aspiration samples taken from the regional lymph nodes. Read More

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November 2018
3 Reads

Clinico-pathological features and survival of patients with malignant exocrine pancreatic neoplasms: The AC Camargo Cancer Center experience.

J Surg Oncol 2018 Nov 27. Epub 2018 Nov 27.

Department of Abdominal Surgery, A.C. Camargo Cancer Center, São Paulo, SP, Brazil.

Background: Pancreatic cancer plays an important role in cancer-related mortality. Few studies have been performed in Brazil to characterize patients affected by this disease. We aimed to describe the clinico-pathological characteristics and the survival of patients with pancreatic cancer seen at AC Camargo Cancer Center (ACCCC). Read More

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November 2018
1 Read

Extremely Low Hepatitis C prevalence among HIV co-infected individuals in 4 countries in sub-Saharan Africa.

AIDS 2018 Nov 16. Epub 2018 Nov 16.

Epicentre, Paris, France.

: A multicentric, retrospective case-series analysis (facility-based) in five sites across Kenya, Malawi, Mozambique, and Uganda screened HIV-positive adults for hepatitis C virus (HCV) antibodies using Oraquick rapid testing and viral confirmation (in three sites). Results found substantially lower prevalence than previously reported for these countries compared with previous reports, suggesting that targeted integration of HCV screening in African HIV programs may be more impactful than routine screening.This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4. Read More

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November 2018
1 Read

IgG4-related respiratory disease.

Authors:
Shoko Matsui

Mod Rheumatol 2018 Nov 24:1-10. Epub 2018 Nov 24.

a Health Administration Center, University of Toyama , Toyama , Japan.

IgG4-related diseases (IgG4-RDs), such as autoimmune pancreatitis and IgG4-related Mikulicz disease, are often accompanied by intrathoracic lesions, which are called IgG4-related respiratory disease (IgG4-RRD). IgG4-RRD has few subjective symptoms, and is usually detected during workup of patients with extra-thoracic lesions of IgG4-RD. IgG4-RRD is characterized by various conditions, including masses, nodules, thickening, and infiltration at numerous sites in the thorax through lymphatic routes. Read More

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November 2018
3 Reads

Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric in silico ROCOCO trial.

Acta Oncol 2018 Nov 26:1-9. Epub 2018 Nov 26.

d OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Cal Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden, Rossendorf , Dresden , Germany.

Background And Purpose: Patients with low-grade glioma (LGG) have a prolonged survival expectancy due to better discriminative tumor classification and multimodal treatment. Consequently, long-term treatment toxicity gains importance. Contemporary radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), tomotherapy (TOMO) and intensity-modulated proton therapy (IMPT) enable high-dose irradiation of the target but they differ regarding delivered dose to organs at risk (OARs). Read More

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November 2018
1 Read

Accuracy of dermoscopy in distinguishing erythroplasia of Queyrat from common forms of chronic balanitis: results from a multicentric observational study.

J Eur Acad Dermatol Venereol 2018 Nov 23. Epub 2018 Nov 23.

Department of Medical Area, Institute of Dermatology, University of Udine, Udine, Italy.

Background: Clinical differentiation of erythroplasia of Queyrat (EQ) and chronic forms of balanitis may be challenging, especially in early phases or in overlapping cases. Dermoscopy has been shown to be a useful supportive tool in facilitating the distinction between tumoral and inflammatory skin conditions; yet, data on EQ and balanitis are scarce or sparse.

Objectives: To systematically assess the dermoscopic features of both EQ and common forms of chronic balanitis and to investigate the accuracy of dermoscopy in distinguishing these conditions. Read More

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November 2018
2 Reads

Use of balloon catheter dilation and steroid-eluting stent in light and severe rhinosinusitis of frontal sinus: a multicenter retrospective randomized study.

Eur Rev Med Pharmacol Sci 2018 Nov;22(21):7482-7491

Department of Sensory Organs, "Sapienza University", Azienda Policlinico Umberto I, Rome, Italy.

Objective: Frontal sinus surgery has an increased rate of re-stenosis, if compared to other sinuses. It depends mainly on recurrent inflammation and abnormal scarring at the frontal recess and its reduction represents one of the keys to therapeutic success. Balloon catheter dilation (BCD) and implantable sinus stents/spacers represent strategies to improve sinus ventilation respecting the integrity of mucosa and reducing abnormal post-surgical scarring. Read More

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November 2018
3 Reads

Spontaneous middle lobe torsion in a patient with multicentric Castleman disease: A case report.

J Med Imaging Radiat Oncol 2018 Nov 23. Epub 2018 Nov 23.

Department of Medical Imaging, The Townsville Hospital, Townsville, Queensland, Australia.

We describe a rare case of middle lobe lung torsion in a patient with a tension hydrothorax secondary to multicentric Castleman disease. The case demonstrates the difficulty of diagnosing torsion prospectively, and the possible sequelae of delayed detection. Although imaging features can be confusing, an awareness of this condition and careful image interpretation by radiologists could facilitate early recognition and management of a torted lobe. Read More

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November 2018
4 Reads

Maternal smoking during pregnancy and risk of cryptorchidism: a systematic review and meta-analysis.

Eur J Pediatr 2018 Nov 21. Epub 2018 Nov 21.

Department of Urology, Children's Hospital of Chongqing Medical University, Room 806, Kejiao Building (No. 6 Building), No. 136, 2nd Zhongshan Road, Yuzhong District, Chongqing City, 400014, China.

The risk factors for undescended testes in male infants and the underlying pathogenesis still remain unclear. The aim of this study is to identify the relationship between maternal smoking during pregnancy and risk of cryptorchidism. A systematic review was conducted using appropriate search terms to identify articles pertaining to maternal smoking during pregnancy and risk of cryptorchidism. Read More

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November 2018
7 Reads
1.983 Impact Factor

Multicentric Ipsilateral Invasive Breast Carcinomas Might have Higher 21-Gene Recurrence Score Compared with Multifocal Ipsilateral Invasive Breast Carcinomas.

Authors:
Kadri Altundag

Ann Surg Oncol 2018 Nov 19. Epub 2018 Nov 19.

MKA Breast Cancer Clinic, Tepe Prime, 06800, Cankaya, Ankara, Turkey.

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November 2018
1 Read

Biologic Agents in the Treatment of Multicentric Castleman Disease.

Turk Thorac J 2018 Oct 1;19(4):220-225. Epub 2018 Oct 1.

Department of Thoracic Surgery, University College London Hospitals NHS Foundation Trust, London, United Kingdom.

Multicentric Castleman disease (MCD) causes an extensive range of systematic symptoms and can be life-threatening if not treated promptly and appropriately. The pathophysiology of the disease remains unclear; however, interleukin 6 (IL-6) pathway and human herpesvirus 8 infection appear to play an important role. As a result, the treatment of MCD remains complex and often insufficient, although a plethora of therapeutic approaches have been used. Read More

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October 2018
1 Read

Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA.

Proc Natl Acad Sci U S A 2018 Dec 19;115(50):12805-12810. Epub 2018 Nov 19.

HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

Noncoding RNAs have substantial effects in host-virus interactions. Circular RNAs (circRNAs) are novel single-stranded noncoding RNAs which can decoy other RNAs or RNA-binding proteins to inhibit their functions. The role of circRNAs is largely unknown in the context of Kaposi's sarcoma herpesvirus (KSHV). Read More

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December 2018

Utility of deep neural networks in predicting gross-total resection after transsphenoidal surgery for pituitary adenoma: a pilot study.

Authors:

Neurosurg Focus 2018 Nov;45(5):E12

OBJECTIVEGross-total resection (GTR) is often the primary surgical goal in transsphenoidal surgery for pituitary adenoma. Existing classifications are effective at predicting GTR but are often hampered by limited discriminatory ability in moderate cases and by poor interrater agreement. Deep learning, a subset of machine learning, has recently established itself as highly effective in forecasting medical outcomes. Read More

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November 2018
4 Reads

[Machine perfusion: new opportunities in abdominal organ transplantation].

Orv Hetil 2018 Nov;159(46):1882-1890

Transzplantációs és Sebészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Baross u. 23., 1082.

Machine perfusion of marginal grafts might be a possible solution to organ shortage and a promising tool for reducing waiting list morbidity and mortality. In recent years, optimizing the circumstances of organ preservation prior to implantation via machine perfusion has become a hot topic of research. Machine perfusion offers a platform for organ reconditioning, assessment of cell viability and function, pharmacological preconditioning, prolongation of preservation time (ischemia time) and finally reducing graft injury. Read More

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November 2018
1 Read

Immunohistochemical expression of Ki-67, Cyclin D1, p16INK4a, and Survivin as a predictive tool for recurrence and progression-free survival in papillary urothelial bladder cancer pTa / pT1 G2 (WHO 1973).

Urol Oncol 2018 Nov 13. Epub 2018 Nov 13.

Department of Urology, University Clinic Hospital of Valencia. Surgery Department, Universitat de València, Valencia, Spain.

Objectives: To investigate the expression of several immunohistochemical (IHC) markers and their predictive ability for the recurrence-free and progression-free survival of papillary urothelial bladder cancer (UBC) pTa/pT1 G2 (WHO 1973) compared to classical anatomo-clinical variables using a multidimensional analysis.

Materials And Methods: A population-based cohort of 213 primary stage UBC (pTa/pT1) G2 (WHO 1973) was evaluated by classic anatomopathological variables and characterized by immunohistochemistry (23 IHC markers, representative of different oncogenic pathways). The most important variables as a predictor of recurrence-free and progression-free survival were selected using multidimensional statistical models, such as random survival forests and least absolute shrinkage and selection operator (. Read More

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November 2018
1 Read

Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity.

Int J Mol Sci 2018 Nov 15;19(11). Epub 2018 Nov 15.

Center for Biotechnology and Cell Therapy, São Rafael Hospital, Bahia 41253-190, Brazil.

MicroRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally. They are involved in the regulation of physiological processes, such as adaptation to physical exercise, and also in disease settings, such as systemic arterial hypertension (SAH), type 2 diabetes mellitus (T2D), and obesity. In SAH, microRNAs play a significant role in the regulation of key signaling pathways that lead to the hyperactivation of the renin-angiotensin-aldosterone system, endothelial dysfunction, inflammation, proliferation, and phenotypic change in smooth muscle cells, and the hyperactivation of the sympathetic nervous system. Read More

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November 2018
8 Reads

Mental Illness and Prejudices in Psychiatric Professionals. Data from the Social Stigma Questionnaire for Psychiatric Professionals: A Multicentre Study.

Psychiatr Danub 2018 Nov;30(Suppl 7):479-484

DSM ASL NA 3 SUD, "Centro Diurno" of Mental Health 57, via Marconi 66, 80059 Torre del Greco (NA), Italy,

The prejudices about mental illness and the related social stigma are still present in the population. People suffer from both the disease and the marginalization behaviors implemented by the "so-called healthy" towards them and their relatives. Even psychiatric professionals can get sick and suffer for the same reason. Read More

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November 2018
6 Reads

Extremely preterm infants in Tunisia: Where are we now?

Tunis Med 2018 Aug - Sep;96(8-09):510-513

Background: Extremely preterm infants are newborns born before 28 weeks of gestation. Survival of these immature newborns depends on resuscitation and the quality of care during hospitalization.

Objective: To determine survival and neurologic outcomes at2 years after extremely preterm birth. Read More

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November 2018
3 Reads

Primary bone lymphoma: tunisian multicentric retrospective study about 32 cases.

Tunis Med 2018 May;96(5):269-272

Aim: To report the epidemiologic, clinical features, treatment modalities and prognosis of primary bone lymphomas (PBL) within a retrospective Tunisian series.

Methods: We collected cases of histologically confirmed PBL in 3 medical oncology departments from northern and central Tunisia andwe analyzed their characteristics.

Results: From January 1990 to July 2014, we collected 32 patients with histologically proven PBL, having a median age of 53 years. Read More

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May 2018
2 Reads

A Familial Case of Multicentric Carpotarsal Osteolysis Syndrome and Treatment Outcome.

J Pediatr Genet 2018 Dec 16;7(4):174-179. Epub 2018 Jun 16.

Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States.

Multicentric carpotarsal osteolysis syndrome (MCTO) is a rare skeletal disorder caused by heterozygous mutations in the gene (v-maf musculoaponeurotic fibrosarcoma oncogene ortholog B). This is an autosomal dominant condition with a high frequency of sporadic cases. MCTO is characterized by osteolysis of the carpal, metacarpal, and tarsal bones beginning in early childhood with musculoskeletal rheumatologic symptoms such as pain and disability. Read More

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December 2018
4 Reads