select PMID, numCitations, impactFactor from LINK_AUTHORS_PMID where PMID IN ('30407282','30385208','30341954','30317044','30313087','30309100','30285830','30231229','30198156','30191416','30186650','30138963','30113777','30075412','30065057','30018833','29980195','29959772','29850348','29751094','29730988','29730431','29721502','29706125','29692510','29669771','29582123','29549434','29534376','29531007','29458886','29368901','29266078','29266072','29241916','29234256','29229001','29068465','29043712','29031171','29030159','29024135','28969729','28960053','28946989','28929000','28927039','28921452','28919146','28893003') AND (numCitations > 0 OR impactFactor is not null) order by numCitations DESC, impactFactor DESCselect PMID, numCitations, impactFactor from LINK_AUTHORS_PMID where PMID IN ('30521869','30519672','30508805','30506360','30504698','30503267','30503199','30502496','30517661','30517076','30515338','30513559','30508918','30489173','30487754','30486509','30485897','30485707','30476149','30471368','30471353','30471132','30470961','30465464','30462683','30459709','30448088','30446521','30445974','30443115','30442826','30439518','30430314','30428262','30427868','30426882','30422632','30421155','30415702','30415435','30411351','30407282','30406704','30406448','30403766','30403655','30400031','30392973','30392113','30391480') AND (numCitations > 0 OR impactFactor is not null) order by numCitations DESC, impactFactor DESC
9,455 results match your criteria Mullerian Duct Anomalies
Life Sci 2018 Dec 3. Epub 2018 Dec 3.
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:
Aims: Electro-acupuncture (EA) is frequently recommended as a complementary therapy for premature ovarian failure (POF) in the clinical. However, little information exists about its potential treatment mechanisms. The study was designed to observe the effect of EA to ovarian function and fertility in POF mice model, and investigated its potential mechanisms on PI3K/AKT/mTOR signaling pathway. Read More
J Endocr Soc 2018 Dec 15;2(12):1345-1356. Epub 2018 Oct 15.
University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Context: Recombinant human FSH (r-hFSH), given to prepubertal boys with hypogonadotropic hypogonadism (HH), may induce Sertoli cell proliferation and thereby increase sperm-producing capacity later in life.
Objective: To evaluate the effects of r-hFSH, human chorionic gonadotropin (hCG), and testosterone (T) in such patients.
Design And Setting: Retrospective review in three tertiary centers in Finland between 2006 and 2016. Read More
Theriogenology 2018 Nov 22;125:335-341. Epub 2018 Nov 22.
Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, USA.
The objectives of this study were to evaluate; 1) the stability of measured serum anti-Müllerian hormone (AMH) concentrations in samples after multiple freeze-thaw cycles, 2) the repeatability of AMH concentrations within mares during the same breeding season as well as across breeding seasons, and 3) the relationship between serum AMH concentrations and fertility (measured as first cycle pregnancy rates) in thoroughbred mares. For the first aim, AMH concentrations (n = 9) were examined across four freeze-thaw cycles with no significant change in measured AMH concentrations. For the second aim, serum AMH concentrations (n = 12) were examined over three successive estrous cycles and over two successive breeding seasons and AMH levels were significantly correlated for individual animals within (r; 0. Read More
Sex Dev 2018 Dec 1. Epub 2018 Dec 1.
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a disorder of sex development which affects 1 in 4,500 females and is characterized by agenesis of müllerian structures, including the uterus, cervix, and upper vagina. It can occur in isolation (type 1) or in conjunction with various anomalies (type 2), with a subset of these comprising müllerian, renal, and cervicothoracic abnormalities (MURCS) association. The genetic causes of MRKH have been investigated previously yielding limited results, with massive parallel sequencing becoming increasingly utilized. Read More
Gynecol Oncol 2018 Nov 29. Epub 2018 Nov 29.
Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA 02115, United States of America. Electronic address:
Most ovarian carcinomas are high-grade serous carcinomas (HGSC) that contain TP53 mutations, present at advanced stage, and eventually become resistant to chemotherapy. The rapid evolution of this disease has been attributed to an origin in the distal fallopian tube, in the form of serous tubal intraepithelial carcinomas (STICs). This has led to a disease model where malignancy develops first in the tube and spreads to the peritoneum or regional lymph nodes. Read More
Reprod Biomed Online 2018 Nov 23. Epub 2018 Nov 23.
Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, No.13 Hang Kong Road, Wuhan Hubei 430030, China; Reproductive Medicine Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Research Question: Is humanin present in the human ovary and follicular fluid? What relationship exists between humanin concentration in the follicular fluid and ovarian reserve and clinical outcomes after IVF and intracytoplasmic sperm injection (ICSI)?
Design: Follicular fluid samples were collected from 179 patients undergoing their first IVF or ICSI cycle during oocyte retrieval. Ovarian tissues were collected from two patients undergoing surgery for ovarian cysts. Ovarian humanin localization was analysed using immunofluorescence staining. Read More
J Pediatr Adolesc Gynecol 2018 Nov 28. Epub 2018 Nov 28.
Institute of Maternal and Child Research, School of Medicine, University of Chile.
Study Objective: To compare ovarian function between adolescents conceived using assisted reproductive technology (AcART) and adolescents who were conceived spontaneously (AcSP).
Design: Multicenter study of ovarian function in AcART due to male or tubal infertility.
Setting: University Hospital PARTICIPANTS: We evaluated 22 AcART and 53 AcSP at 1-2 years after menarche. Read More
J Clin Endocrinol Metab 2018 Dec 3. Epub 2018 Dec 3.
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Context: Women with polycystic ovary syndrome (PCOS) have a higher prevalence of metabolic syndrome (MetS), but whether they develop MetS earlier than women without PCOS is unknown. Understanding the impact of PCOS on the timing of MetS onset is important for screening and clinical care in this population.
Design: Women with PCOS-like status ("PCOSp") were identified from participants of the Michigan Bone Health and Metabolism Study based upon history of irregular menstrual cycles, high free-androgen index and high levels of anti-müllerian hormone. Read More
Horm Mol Biol Clin Investig 2018 Dec 5. Epub 2018 Dec 5.
Regional Children's Clinical Hospital, Kemerovo, Russia.
Background The objective was to estimate ovarian reserve in adolescent girls born prematurely. Materials and methods Two hundred adolescent girls aged 15-16 years who were born prematurely and full term were studied with laboratory, ultrasound and statistical methods. Results Statistically significant differences of the main parameters that characterize ovarian reserve in adolescent girls born prematurely compared to those born full term were specified. Read More
Case Rep Obstet Gynecol 2018 1;2018:7865832. Epub 2018 Nov 1.
Department of Pediatrics, Hoshi General Hospital, Koriyama-shi, Fukushima, Japan.
Clitoral hypertrophy is caused by disorders of sex development and it is observed from birth in most cases. We encountered a patient in whom normal morphology at birth may have acquired deformity and hypertrophy. The patient was a 10-year-old girl with a chief complaint of pudendal deformity. Read More
Endocrinol Metab (Seoul) 2018 Dec;33(4):447-458
Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.
Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathies among reproductive-age women. Its metabolic features often overlap with those associated with metabolic syndrome (MS) and insulin resistance syndrome (IRS). The objective of this study was to determine the prevalence and predictors of MS and IRS in infertile Vietnamese women with PCOS. Read More
Medicine (Baltimore) 2018 Nov;97(48):e13305
Departments of Urology.
Rationale: Persistent Müllerian duct syndrome (PMDS) is rare form of male pseudohermaphroditism characterized by the presence of uterus and fallopian tubes with normal external genitalia and secondary sexual characteristics. Transverse testicular ectopia (TTE) is also a rare form of testicular ectopia that may be associated with PMDS.
Patient Concerns: We present a 2-year-old boy who presented with bilateral non-palpable testes with left inguinal mass. Read More
J Psychosom Obstet Gynaecol 2018 Nov 29:1-9. Epub 2018 Nov 29.
a Merrion Fertility Clinic-Reproductive Medicine Unit , Dublin 2 , Ireland.
Research Question: Significant medical benefits could be derived from universal AMH screening for women in their mid to late twenties. We aimed to investigate the psychological and emotional responses of women to being informed of their anti-Mullerian hormone (AMH) result with a view to informing the possible introduction of universal AMH screening.
Materials And Methods: This was a prospective qualitative study using semi-structured in-depth interviews of women attending a reproductive medicine clinic who had ovarian reserve testing performed via measurement of serum AMH levels, as part of their gynecological investigations. Read More
Front Physiol 2018 14;9:1600. Epub 2018 Nov 14.
Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, United States.
There is an increasing recognition that vitamin D plays important roles in female reproduction. Recent studies demonstrated that 1α,25-dihydroxyvitamin D3 (VD3), the biologically active form of vitamin D, improved ovarian follicle survival and growth . Therefore, we investigated the direct effects of VD3 at the specific preantral and antral stages of follicular development, and tested the hypothesis that vitamin D receptor (VDR) and enzymes critical for vitamin D biosynthesis are expressed in the primate ovary. Read More
Cancers (Basel) 2018 Nov 28;10(12). Epub 2018 Nov 28.
Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Beginning with the discovery of the -associated ovarian cancer susceptibility genes and subsequent detailed examination of risk-reducing salpingo-oophorectomy (RRSO) specimens, a new paradigm of ovarian carcinogenesis has unfolded with attention to the distal fallopian tube. The primary focus has been an early cancer or neoplasm in the fallopian tube which is seen in virtually all incidentally discovered high-grade serous cancers in asymptomatic women. This high-frequency of tubal involvement in early serous neoplasm (usually in the form of serous tubal intraepithelial carcinoma-STIC) has galvanized attention to this organ as a primary source of this disease. Read More
Rev Bras Ginecol Obstet 2018 Nov 28;40(11):661-663. Epub 2018 Nov 28.
Faculty of Medicine, Universidade de Sao Paulo, Ribeirão Preto, SP, Brazil.
Cancer Med 2018 Nov 28. Epub 2018 Nov 28.
Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
We hypothesized that endometrial carcinoma (EC) patients with a prior cancer diagnosis, after accounting for EC arising after tamoxifen-treated prior breast carcinoma, are more likely to have an underlying genetic basis. We used information from a population-based study to compare measured risk factors, tumor characteristics, survival, and known mismatch repair (MMR) pathogenic variant status for EC subgroups according to prior diagnosis of cancer (none, breast cancer tamoxifen-treated or not, Lynch Syndrome (LS)-associated cancer). Family history of any cancer was increased for EC cases with prior breast cancer, both tamoxifen treated (P = 0. Read More
Hum Reprod 2018 Nov 24. Epub 2018 Nov 24.
University of Paris-Sud and University Paris-Saclay, Le Kremlin-Bicêtre, France.
Study Question: Does the phenotype of women with normosmic congenital hypogonadotrophic hypogonadism (nCHH) and pituitary resistance to GnRH caused by biallelic mutations in the GnRH receptor (GNRHR) (nCHH/bi-GNRHR) differ from that of women with polycystic ovary syndrome (PCOS)?
Summary Answer: Women with nCHH/bi-GNRHR have variable pubertal development but nearly all have primary amenorrhea and an exaggerated LH response to GnRH stimulation, similar to that seen in women with PCOS.
What Is Known Already: Women with nCHH/bi-GNRHR are very rare and their phenotype at diagnosis is not always adequately documented. The results of gonadotrophin stimulation by acute GnRH challenge test and ovarian features have not been directly compared between these patients and women with PCOS. Read More
Urology 2018 Nov 21. Epub 2018 Nov 21.
A longitudinal vaginal septum can be obstructive or non-obstructive. We report on an adult woman who presented with involuntary fluid loss per vagina and had a partially obstructive longitudinal vaginal septum. A 36 year-old nulliparous female presented with malodorous, clear, leakage per vagina that she described as "urinary incontinence". Read More
J Pediatr Adolesc Gynecol 2018 Nov 21. Epub 2018 Nov 21.
Department of Obstetrics and Gynecology University of Iowa Carver College of Medicine 200 Hawkins Dr. Iowa City, IA 52241.
Background: Müllerian aplasia or Mayer-Rokitansky-Küster-Hauser syndrome is described as congenital absence of the proximal vagina with or without absence of the cervix and uterus, most often recognized following the onset of primary amenorrhea.
Case: An 18-year-old female presented to a free medical clinic in Arcahaie, Haiti with primary amenorrhea, abdominal distention and cyclic monthly abdominal pain. Physical exam was significant for uterus palpable superior to the umbilicus, absence of vagina, and rectal exam without palpable vagina or cervix. Read More
Histopathology 2018 Nov 24. Epub 2018 Nov 24.
Department of Diagnostic Pathology, Anjo Kosei Hospital, 28 Higashi-hirokute, Anjo-cho, Anjo, Aichi, 446-8602, Japan.
Mesonephric adenocarcinoma (MNAC) is a rare neoplasm that presumably develops from the mesonephric remnants, occurring mostly in the uterine cervix and, to a lesser extent, the vagina, uterine body, ovary, and para-adnexal soft tissues. Histologically, MNAC exhibits a variety of architectural growth patterns, even within the same tumour, including tubular, glandular, papillary, solid, and retiform, and therefore may be confused with more common carcinomas of Müllerian origin. Moreover, the tubules with luminal eosinophilic secretions, a common characteristic of MNACs, may result in consideration of thyroidal carcinoma when tumours spread beyond the pelvis. Read More
J Assist Reprod Genet 2018 Nov 23. Epub 2018 Nov 23.
Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77843-4466, USA.
Purpose: This study aims to determine if intra-ovarian injection of bone marrow-derived mesenchymal stem cells (MSCs) improves or restores ovarian function in aged females.
Methods: Prospective randomized study of eight aged mares and six young mares receiving intra-ovarian injection of MSCs or vehicle. Main outcome measures were antral follicle count and serum anti-Müllerian hormone (AMH) (aged and young mares), and for aged mares, oocyte meiotic and developmental competence; gross and histological ovarian assessment; evaluation of presence of chimerism in recovered granulosa cells and in ovarian tissue samples; and gene expression in ovarian tissue as assessed by RNA sequencing. Read More
Aging Male 2018 Nov 22:1-7. Epub 2018 Nov 22.
c Department of Dermatology, Venereology and Andrology, Faculty of Medicine , Aswan University , Aswan , Egypt.
Background And Aim: We examined the relationship among vit.D, AMH, FT3, FT4, and TSH, in addition to the serum levels of reproductive hormones (FSH, LH, prolactin, and free testosterone), in oligoasthenoteratozoospermia and azoospermia patients in a cohort of infertile men from Egypt to establish a clinical marker/cause-effect relationship.
Methods: This cross-sectional cohort study was carried out on 301 men (105 males with oligoasthenoteratozoospermia and 96 males with azoospermia), in addition to 100 controls. Read More
PLoS One 2018 21;13(11):e0207080. Epub 2018 Nov 21.
United States Department of Agriculture-Agricultural Research Services, Pollinating Insects-Biology, Management, and Systematics Research Laboratory, Logan, Utah, United States of America.
Bumble bees (Bombus Latrielle) are significant pollinators of flowering plants due to their large body size, abundant setae, and generalist foraging strategies. However, shared setal coloration patterns among closely and distantly related bumble bee species makes identification notoriously difficult. The advent of molecular genetic techniques has increased our understanding of bumble bee evolution and taxonomy, and enables effective conservation policy and management. Read More
Front Endocrinol (Lausanne) 2018 16;9:603. Epub 2018 Oct 16.
Department of Obstetrics and Gynecology, Herlev Gentofte Hospital, Herlev, Denmark.
This study examined longitudinal, age-related and intra-individual variation in Anti-Müllerian Hormone (AMH) in regular menstruating women and correlated the hormonal levels to the antral follicle count (AFC). The impact of variations on an algorithm for calculation of follitropin-dose for ovarian stimulation were also tested. The study was carried out at a fertility clinic of a tertiary university hospital and had a prospective trial design. Read More
Clin Breast Cancer 2018 Oct 23. Epub 2018 Oct 23.
Université Clermont Auvergne, Centre Jean Perrin, INSERM, U1240 Imagerie Moléculaire et Stratégies Théranostiques, Clermont-Ferrand, France.
Background: Young patients with breast cancer treated with chemotherapy can experience ovarian failure, which can lead to chemotherapy-induced menopause (CIM) impacting the quality of life (QoL). A prospective study was set out to evaluate the impact of CIM on QoL in women of childbearing age with non-metastatic breast cancer, and this article reports results of the interim analysis conducted to evaluate feasibility and to see preliminary results.
Patients And Methods: A total of 58 women (age, 18-46 years) with newly diagnosed breast cancer and treated with chemotherapy were eligible. Read More
Genetics 2018 Nov 16. Epub 2018 Nov 16.
University of California, Davis
In laboratory strains of zebrafish, sex determination occurs in the absence of a typical sex chromosome and it is not known what regulates the proportion of animals that develop as males or females. Many sex determination and gonad differentiation genes that act downstream of a sex chromosome are well conserved among vertebrates, but studies that test their contribution to this process have mostly been limited to mammalian models. In mammals, WNT4 is a signaling ligand that is essential for ovary and Müllerian duct development, where it antagonizes the male-promoting FGF9 signal. Read More
Orphanet J Rare Dis 2018 Nov 16;13(1):207. Epub 2018 Nov 16.
Children's Hospital, Pediatric Research Center, HUS Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Background: Patients with cartilage-hair hypoplasia (CHH), a rare metaphyseal chondrodysplasia, manifest severe growth failure, variable immunodeficiency and increased risk of malignancies. The impact of CHH on gynecologic and reproductive health is unknown. Vulnerability to genital infections may predispose CHH patients to prolonged human papillomavirus (HPV) infections potentially leading to cervical, vaginal and vulvar cancer. Read More
J Indian Assoc Pediatr Surg 2018 Oct-Dec;23(4):203-205
Department of Pediatric Surgery, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India.
Context: Persistent Mullerian duct syndrome (PMDS) is a rare disorder. It is a type of male pseudohermaphroditism, usually presenting as "Hernia Uteri Inguinalis".
Aims: This study aims to present our experience of PMDS, over a 7-year period. Read More
J Rheumatol 2018 Nov 15. Epub 2018 Nov 15.
From the Division of Rheumatology and Immunology, Department of Medicine, Duke University Medical Center; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA. Pfizer Inc. provided the funding for this project through its ASPIRE award program for investigator-initiated studies. It had no say on the design or conduct of the research, and did not alter the manuscript. M.E. Clowse is a consultant for UCB regarding issues surrounding the use of certolizumab for RA in pregnancy. This work does not involve issues of infertility or AMH. A.M. Eudy, PhD, Postdoctoral Associate, Division of Rheumatology and Immunology, Duke University Medical Center; G. McDaniel, PA-C, Clinical Research Coordinator, Division of Rheumatology and Immunology, Duke University Medical Center; W.W. Hurd, MD, MSc, MPH, Professor and Director, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center; M.E. Clowse, MD, MPH, Associate Professor of Medicine, Division of Rheumatology and Immunology, Duke University Medical Center. Address correspondence to A.M. Eudy, Duke University Medical Center, Division of Rheumatology and Immunology, DUMC 3490, Durham, North Carolina 27710, USA. E-mail: Accepted for publication August 10, 2018.
Objective: We sought to identify causes for infertility in women with and without rheumatoid arthritis (RA).
Methods: Women with RA were matched to healthy controls. Differences in anti-Müllerian hormone (AMH) and anovulation were analyzed. Read More
J Gynecol Obstet Hum Reprod 2018 Nov 12. Epub 2018 Nov 12.
Department of Gynecology, Centre Médico-Chirurgical d'Obstétrique (CMCO), Hôpitaux universitaires de Strasbourg, France.
Research Question: Is luteal phase stimulation capable of improving fertility preservation?
Materials And Methods: We performed a retrospective cohort study of consecutive ovarian stimulations, during July 2012 and September 2018 at Strasbourg University Teaching Hospital in France. Enrollment criteria were patients aged below 40 who had been referred to our center following a diagnosis of cancer or requiring gonadotoxic treatment. All patients enrolled had regular menstrual cycles and normal ovulation. Read More
J Assist Reprod Genet 2018 Nov 15. Epub 2018 Nov 15.
Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.
Purpose: To determine the effects of PGL1001, a somatostatin receptor isoform-2 (SSTR-2) antagonist, on ovarian follicle development, oocyte fertilization, and subsequent embryo developmental potential in the rhesus macaque.
Methods: Cycling female rhesus macaques (N = 8) received vehicle through one menstrual (control) cycle, followed by daily injections of PGL1001, a SSTR-2 antagonist, for three menstrual (treatment) cycles. Main endpoints include overall animal health and ovarian hormones (e. Read More
Syst Biol Reprod Med 2018 Nov 14:1-8. Epub 2018 Nov 14.
a Department of Obstetrics and Gynecology, Rout Center , University of Tennessee Health Science Center , Memphis , TN , USA.
We sought to determine serum AMH levels in the maternal circulation, and the umbilical artery and vein, in normal women and women with PCOS, and their neonates at time of delivery. This represents a cross-sectional study of 57 pregnant patients who presented to the labor and delivery suite and subsequently delivered. We obtained maternal, as well as fetal blood from both, umbilical artery and vein. Read More
PLoS One 2018 14;13(11):e0206111. Epub 2018 Nov 14.
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
The use of corifollitropin alfa (CA) in assisted reproductive technology (ART) cycles is dependent on the antral follicle count and body weight of patients. The present study investigated the safety and efficacy of using 100μg of CA in predicted excessive responders based on serum anti-Mullerian hormone (AMH) level. The results of 381 ART cycles stimulated by CA versus daily recombinant follicle-stimulation hormone (rFSH) in patients with low (<1. Read More
Urologia 2018 Nov 28;85(4):177-181. Epub 2018 Mar 28.
1 Pathology Service, Addarii Institute of Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Introduction:: Persistent Mullerian duct syndrome is a rare disorder of male organ development characterized by internal male pseudohermaphroditism. Persistent Mullerian duct syndrome is usually an incidental finding in patients presenting cryptorchidism, inguinal hernia, or a previous story of undescended testes.
Case Description:: We report on two cases of persistent Mullerian duct syndrome: an adult fertile male with uterus and ectopic prostate occurring as pelvic mass and a 75-year-old organ donor with uterus and two fallopian tubes, discovered in course of organ recruitment. Read More
Chem Res Toxicol 2018 Nov 27. Epub 2018 Nov 27.
Department of Obstetrics and Gynecology , The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , 109 Xueyuan West Road , Wenzhou , Zhejiang 325027 , China.
Ziram is a dimethyldithiocarbamate fungicide, which may influence the male reproductive system as a potential endocrine disruptor. We interrogated the disruption of ziram on rat progenitor Leydig cell development. Prepubertal male Sprague-Dawley rats were orally treated with 0, 2, 4, or 8 mg/kg ziram for 2 weeks. Read More
Hormones (Athens) 2018 Nov 12. Epub 2018 Nov 12.
Institute of Medical Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Over the last decade, huge achievements have been made in the fields of neurophysiology, molecular endocrinology, and biochemistry, as well as in the successful translation of clinical research into diseases into clinical practice. As regards female reproduction, most of the advances made in this area were achieved in gonadal axis regulation, regulation of behavior through sex steroids, reproductive genetics, preservation of ovarian reproductive function, steroid profiling, and metabolic and overall reproductive outcomes. The coming years are expected to bring further understanding of the relationships between nutrition, energy metabolism, and reproductive function and to succeed in identifying new genetic markers linked to adverse metabolic and unfavorable cardiovascular outcomes in women. Read More
Curr Biol 2018 Nov 25;28(21):3469-3474.e4. Epub 2018 Oct 25.
Department of Ecology & Evolution, University of Chicago, Chicago, IL 60637, USA. Electronic address:
Neotropical Heliconius butterflies display a diversity of warningly colored wing patterns, which serve roles in both Müllerian mimicry and mate choice behavior. Wing pattern diversity in Heliconius is controlled by a small number of unlinked, Mendelian "switch" loci . One of these, termed the K locus, switches between yellow and white color patterns, important mimicry signals as well as mating cues [2-4]. Read More
Arch Gynecol Obstet 2018 Nov 10. Epub 2018 Nov 10.
Institute of Pathology, Klinikum Bayreuth, Preuschwitzer Strasse 101, 95445, Bayreuth, Germany.
Background: Malignant ascites often develops in patients with ovarian cancer, but there is a lack of more detailed characterization of the different histological subtypes.
Methods: Ascites specimens from patients with ovarian cancer who were treated at Bayreuth Hospital from 2006 to 2015, with follow-up until December 2016, were reevaluated retrospectively.
Results: A total of 191 women (mean age 64 years, range 48-79) were included, of whom 180 (94. Read More
Int J Gynaecol Obstet 2018 Nov 8. Epub 2018 Nov 8.
Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Objective: To explore assisted reproductive outcomes among women with different polycystic ovary syndrome (PCOS) phenotypes.
Methods: A retrospective cohort study included women with PCOS who were treated at Yazd Research and Clinical Center for Infertility, Yazd, Iran, using the GnRH antagonist protocol between April 1, 2015, and August 31, 2017. Clinical pregnancy was the primary outcome, and chemical pregnancy, implantation rate, fertilization rate, and spontaneous abortion rate, were the secondary outcomes that were evaluated among four defined phenotypes of women with PCOS. Read More
Medicine (Baltimore) 2018 Nov;97(45):e12822
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, P. R. of China.
Rationale: Vertebral defect, anal atresia, cardiac defect, tracheoesophageal fistula/esophageal atresia, renal defect, and limb defect (VACTERL) association and Müllerian duct anomalies are rare conditions. We present a rare condition with the co-occurrence of the VACTERL association and Müllerian duct hypoplasia to characterize patients' clinical presentations, outcomes, and treatment.
Patient Concerns: An 11-year-old girl presented to our hospital with severe lower abdominal pain, lower vaginal atresia with enlargement of the upper vagina and a bicornuate uterus with a Y-shaped uterine cavity filled with hematometra on pelvic magnetic resonance imaging. Read More
J Obstet Gynaecol 2018 Nov 8:1-2. Epub 2018 Nov 8.
a Gynecology and Obstetrics Department , UPJŠ LF and UNLP Košice , Košice , Slovakia.
J Assist Reprod Genet 2018 Nov 8. Epub 2018 Nov 8.
Department of Reproductive Medicine and Gynecological Endocrinology, University Medical Centre Maribor, Ljubljanska ulica 5, 2000, Maribor, Slovenia.
Purpose: The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in selected genes, responsible for hormonal regulation of folliculogenesis, are associated with response to controlled ovarian hyperstimulation (COH) and clinical characteristics of women enrolled in in vitro fertilization (IVF) programs.
Methods: In a cross-sectional study, 60 (IVF) patients underwent COH by using gonadotropin-releasing hormone (GnRH) antagonist and recombinant follicle-stimulating hormone (rFSH) protocol. Patients were classified into three groups: poor-responders (according to Bologna criteria), normo-responders (≤ 15 oocytes), and hyper-responders (> 15 oocytes). Read More
PLoS One 2018 7;13(11):e0207081. Epub 2018 Nov 7.
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
This retrospective analysis compared the efficiency of the gonadotropin- releasing hormone (GnRH) antagonist (GnRH-ant) protocol and the GnRH agonist long (GnRH-a) protocol for patients with diminished ovarian reserve (DOR). A total of 1,233 patients with DOR (anti-Mullerian hormone <1.1 ng/mL) were recruited for this retrospective case-control study. Read More
J Endocrinol 2018 Nov 1. Epub 2018 Nov 1.
C Guigon, Functional and adaptive unit, Universite Paris Diderot, Paris, France.
Anti-Müllerian hormone (AMH) regulates ovarian function in cyclic females, notably by preventing premature FSH-mediated follicular growth and steroidogenesis. Its expression in growing follicles is controlled by FSH and by estradiol (E2). In infantile females, there is a transient increase in the activity of the gonadotrope axis, as reflected by elevated levels of both gonadotropins and E2. Read More
J Endocrinol 2018 Nov 1. Epub 2018 Nov 1.
M Alvarenga, Department of Animal Reproduction and Veterinary Radiology, São Paulo State University, Bocucatu, Brazil.
Anti-Müllerian hormone (AMH) is used as a marker of follicle population numbers and potential fertility in several species including horses but limited data exist across the lifespan. No one has decreased ovarian reserve experimentally to investigate whether a corresponding, quantitative decrease in AMH results. Concentrations of AMH across the lifespan were compiled from 1101 equine females sampled from birth to >33 years of age. Read More
Stem Cell Reports 2018 Nov 1;11(5):1136-1155. Epub 2018 Nov 1.
Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Prentice Women's Hospital, 250 E. Superior Street, Room 3-2306, Chicago, IL 60611, USA. Electronic address:
Defective endometrial stromal fibroblasts (EMSFs) contribute to uterine factor infertility, endometriosis, and endometrial cancer. Induced pluripotent stem cells (iPSCs) derived from skin or bone marrow biopsies provide a patient-specific source that can be differentiated to various cells types. Replacement of abnormal EMSFs is a potential novel therapeutic approach for endometrial disease; however, the methodology or mechanism for differentiating iPSCs to EMSFs is unknown. Read More
Breast Cancer Res Treat 2018 Nov 3. Epub 2018 Nov 3.
Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Dongfeng Road East 651#, Guangzhou, 510060, China.
Purpose: Ovarian function is important for optimizing endocrine treatment in patients with hormone receptor-positive (HR+) early breast cancer (eBC). The aim of the study was to determine whether patients' pretreatment levels of anti-Mullerian hormone (AMH) were associated with menses status after chemotherapy and to build a predictive nomogram model for amenorrhea in women with HR+ eBC.
Methods: Between August 2013 and December 2014, 120 premenopausal patients with HR+ eBC were included retrospectively. Read More
Mech Dev 2018 Oct 31. Epub 2018 Oct 31.
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. Electronic address:
This study utilizes morphological and mechanistic endpoints to characterize the onset of bilateral atresia of the vas deferens in a recently derived cystic fibrosis (CF) rat model. Embryonic reproductive structures, including Wolffian (mesonephric) duct, Mullerian (paramesonephric) duct, mesonephric tubules, and gonad, were shown to mature normally through late embryogenesis, with involution of the vas deferens and/or epididymis typically occurring between birth and postnatal day 4 (P4), although timing and degree of atresia varied. No evidence of mucus obstruction, which is associated with pathology in other CF-affected tissues, was observed at any embryological or postnatal time point. Read More