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Biomed Pharmacother 2018 Dec 12;110:727-732. Epub 2018 Dec 12.

Zhejiang Provincial Key Laboratory of Pathophysiology, Department of Immunology, Medical School of Ningbo University, Ningbo, 315211, China. Electronic address:

Cigarette smoke (CS) is a very important cause of pulmonary inflammatory diseases. Interleukin (IL)-35 is a novel anti-inflammatory cytokine but its role in CS-mediated lung inflammation remains unclear. In the present study, we examined the effect of IL-35 expression on CS-induced lung inflammation in mice. Read More

Paediatr Respir Rev 2018 Nov 24. Epub 2018 Nov 24.

Department of Pediatrics, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy. Electronic address:

People with Duchenne muscular dystrophy (DMD), develop a respiratory muscle weakness that results in weakened cough, airway clearance impairment and over time respiratory failure and death. Assessment of cough effectiveness through vital capacity, peak cough flow and maximal inspiratory and expiratory pressures has been used to identify the optimal timing of cough augmentation techniques initiation. The choice of therapies depends on physician knowledge, and patient/care giver abilities. Read More

J Stomatol Oral Maxillofac Surg 2018 Dec 12. Epub 2018 Dec 12.

Associate Professor, Department of Pathology, Akdeniz University, Faculty of Medicine, Antalya, Turkey.

Simpson-Golabi-Behmel Syndrome (SGBS) is an X-linked overgrowth syndrome characterized by pre- and postnatal overgrowth, typical facial appearance and multiple visceral, skeletal, and neurological anomalies. There is only few information in the current literature, on clinical and particularly dentofacial findings due to recent identification of the syndrome and its clinical overlap with other overgrowth syndromes. The aim of this case report is to present dentofacial findings in a 16-year-old boy who had been diagnosed with SGBS. Read More

J Ethnopharmacol 2018 Dec 12. Epub 2018 Dec 12.

Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Korea; Department of Pathology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do, 26339, Korea. Electronic address:

Ethnopharmacological Relevance: Anthriscus sylvestris L. Hoffmann (AS) is a perennial plant that grows in Asia and Eastern Europe. Its dried root is used to treat conditions such as asthma, bronchitis, and cough. Read More

J Tissue Viability 2018 Dec 5. Epub 2018 Dec 5.

Urology Ward, Pusan National University Hospital, Busan, South Korea.

Purpose: This study examined the incidence of oral mucosa pressure ulcers (PUs) in intensive care unit (ICU) patients and the relationship between biomechanical and physiological variables in onset of PUs.

Methods: A prospective observational descriptive study design was used. We recruited patients over 18 years of age with endotracheal tube (ETT) insertion in three ICUs in a tertiary hospital in Korea. Read More

Curr Opin Insect Sci 2018 Oct 5;29:34-40. Epub 2018 Jun 5.

Laboratório de Química e Função de Proteínas e Peptídeos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Brazil.

The study of insect midgut features has been made possible by the recent availability of transcriptome datasets. These data uncovered the preferential expression of mucus-forming mucins at midgut regions that require protection (e.g. Read More

Biomed Pharmacother 2019 Jan 28;109:2270-2277. Epub 2018 Nov 28.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, No.11 North 3rd Ring East Road, Chao-Yang District, Beijing, 100029, China. Electronic address:

With increasing air pollution, chronic bronchitis (CB) has become a major public health problem worldwide. Previous studies have shown beneficial effects of Bergenin (Ber) on chronic bronchitis. To facilitate understanding of the pathogenesis underlying CB as well as to elucidate the Ber therapeutic mechanism, it is crucial to confirm the rational biomarkers of CB and its treatment. Read More

Biomed Pharmacother 2019 Jan 15;109:1602-1609. Epub 2018 Nov 15.

Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110 029, India.

Calotropis procera, a latex producing plant is known to possess medicinal properties including its beneficial effect in gastrointestinal disorders. The anti-inflammatory effect of its latex in various experimental models is noteworthy and in light of this the present study was carried out with an objective to evaluate its efficacy in ulcerative colitis, an inflammatory condition of the colon. Colitis was induced in rats by acetic acid and the rats were divided into four groups where one group served as experimental control and the other groups were treated with two doses of methanol extract of dried latex of C. Read More

FEMS Microbiol Ecol 2018 Dec 14. Epub 2018 Dec 14.

Marine Biological Association of the United Kingdom, The Laboratory, Citadel Hill, Plymouth, PL1 2PB.

Sediment nitrogen cycling is a network of microbially-mediated biogeochemical processes that are vital in regulating ecosystem functioning. Mucopolysaccharides (mucus) are produced by many invertebrates and have the potential to be an important source of organic carbon and nitrogen to sediment microorganisms. At present, we have limited understanding of how mucopolysaccharide moderates total sediment microbial communities and specific microbial functional groups that drive nitrogen cycling processes. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1434-1435

A 33-year-old man presented with recurrent oral ulcers for more than 10 years,accompanying dyspnea and dysphagia for 1 year and aggravate for 1 month.Physical examination:pharyngeal cavity stenosis,mucous retention, epiglottis was extruded into the infant type. Electronic laryngoscope:Epiglottis curl,bilateral pyriform sinus disappeared. Read More

Klin Lab Diagn 2018 ;63(1):55-59

DNA-Technology LLC, 115478, Moscow, Russia.

The purpose of study is to develop techniques of laboratory diagnostic of leprosy on the basis of polymerase chain reaction. The techniques were worked through such as extraction of DNA from various clinical material (bioptates and scarifcate of skin, scrapes from mucous surface of nose and trophic ulcers, blood serum). The systems of oligonucleotides were constructed to 16S pRNA and probe for identifcation of Mycobacterium leprae in real-time format for amplifer DT-96 ("The DNA-Technology", Russia). Read More

J Clin Immunol 2018 Dec 13. Epub 2018 Dec 13.

Paediatric Immunology Unit, Department of Paediatric Pulmonology, Allergology and Neonatology, Hanover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany.

Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. Read More

Med Sci Monit 2018 Dec 13;24:9045-9053. Epub 2018 Dec 13.

Department of Pulmonary, First Affiliated Hospital of Medical University of Anhui, Anhui Geriatrics Research Institute, Hefei, Anhui, China (mainland).

BACKGROUND The purpose of this study was to explore the function and mechanism of peroxisome proliferator activated receptor agonist (PPARγ) in the toll-like receptor 2 (TLR2)/nod-like receptor with pyrin domain containing 3 (NLRP3) inflammatory corpuscle pathway of asthmatic mice. MATERIAL AND METHODS Eighteen female mice (C57) were randomly divided into 4 groups: the control group, the asthma model group challenged by ovalbumin (OVA), the rosiglitazone group, and the PPARγ agonist rosiglitazone treatment group. The infiltration of peribronchial inflammatory cells as well as the proliferation and mucus secretion of bronchial epithelial goblet cells were observed by hematoxylin and eosin and periodic acid-Schiff staining. Read More

ISME J 2018 Dec 12. Epub 2018 Dec 12.

Laboratory for Biological Geochemistry, School of Architecture, Civil and Environmental Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Under homoeostatic conditions, the relationship between the coral Pocillopora damicornis and Vibrio coralliilyticus is commensal. An increase in temperature, or in the abundance of V. coralliilyticus, can turn this association pathogenic, causing tissue lysis, expulsion of the corals' symbiotic algae (genus Symbiodinium), and eventually coral death. Read More

J Exp Biol 2018 Dec 12;221(Pt 24). Epub 2018 Dec 12.

Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada, N1G 2W1

Hagfishes defend themselves from fish predators by producing defensive slime consisting of mucous and thread components that interact synergistically with seawater to pose a suffocation risk to their attackers. Deployment of the slime occurs in a fraction of a second and involves hydration of mucous vesicles as well as unraveling of the coiled threads to their full length of ∼150 mm. Previous work showed that unraveling of coiled threads (or 'skeins') in Atlantic hagfish requires vigorous mixing with seawater as well as the presence of mucus, whereas skeins from Pacific hagfish tend to unravel spontaneously in seawater. Read More

J Vet Diagn Invest 2018 Dec 12:1040638718817508. Epub 2018 Dec 12.

Department of Veterinary Sciences, University of Wyoming, Laramie, WY (Imus [nee Arnall], Woods).

Seven colostrum-deprived, 3-4-wk-old Rambouillet-Hampshire lambs were inoculated via the mucous membranes with deer adenovirus (DAdV) and monitored for clinical signs for 21 d post-inoculation at which time animals were euthanized and postmortem examinations were performed. Pre-inoculation and post-inoculation serum samples were tested for antibodies to DAdV, ovine adenovirus 7, bovine adenovirus 7, and goat adenovirus 1. Evidence for DAdV infection was determined by virus isolation, PCR tests, and histopathology with immunohistochemistry tests for DAdV. Read More

Front Oncol 2018 21;8:540. Epub 2018 Nov 21.

Department of Coronary and Structural Heart Diseases, Institute of Cardiology, Warsaw, Poland.

A 62-years-old woman was admitted to the hospital because of chronic cough, expectoration of thick mucus, hoarseness and tightness in the precordial area. Computed Tomography (CT) examination revealed the presence of a giant intrapericardial tumor with the dimensions of 80 × 38 × 32 mm. It was located anteriorly and laterally to the left atrium, posteriorly to the pulmonary trunk and the ascending aorta. Read More

Front Microbiol 2018 13;9:2701. Epub 2018 Nov 13.

Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Food Science, University of Vigo, Ourense, Spain.

There are strong evidences that probiotics influence the immune status of the host, in a strain-specific manner, acting in the gastrointestinal tract. On the hypothesis that certain extracellular proteins and peptides from gut bacteria may mediate part of this immunomodulation and assuming they are able to diffuse through the mucus layer and interact with immune cells we have developed this work. Our study attempts to understand the immunomodulatory mechanisms of (i) Pext, the extracellular protein fraction of DSM20079, (ii) HM14, a peptide encrypted in an extracellular glycoside hydrolase from NCIMB 8809 and (iii) O111:B4 lipopolysaccharide (LPS), a well-known pro-inflammatory molecule, over human peripheral blood mononuclear cells (PBMCs). Read More

J Nat Med 2018 Dec 6. Epub 2018 Dec 6.

Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, 8 University Avenue, Yichang, 443002, China.

The aim of this study was to elucidate the gastroprotective activity and possible mechanism of involvement of araloside A (ARA) against ethanol- and aspirin-induced gastric ulcer in mice. The experimental mice were randomly divided into control, model, omeprazole (20 mg/kg, orally) and ARA (10, 20 and 40 mg/kg, orally). Gastric ulcer in mice was induced by intragastric administration of 80% ethanol (10 mL/kg) containing 15 mg/mL aspirin 4 h after drug administration on day 7. Read More

Eur Respir J 2018 Dec 6;52(6). Epub 2018 Dec 6.

Wellcome Trust Centre for Cell-Matrix Research and Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.

J Visc Surg 2018 Dec 3. Epub 2018 Dec 3.

Service de chirurgie digestive, centre hospitalier universtaire Amiens, avenue René-Laennec, 80054 Amiens cedex 01, France; Université Picardie-Jules-Verne, 1, chemin du Thil, 80000 Amiens cedex 01, France; Simplifications des soins patients chirurgicaux complexes, or Simplication of care of complex surgical patients (SSPC), unité de recherché clinique, université Picardie-Jules-Vernes, 80000 Amiens, France. Electronic address:

Pseudomyxoma peritonei is a rare tumor characterized by the presence of mucous disseminated throughout the peritoneal cavity generally arising from the rupture of an appendicular mucocele. Liver scalloping is a highly suggestive image of pseudomyxoma and corresponds to the indentation of the liver compressed by the gelatinous mucin. Read More

Zhonghua Bing Li Xue Za Zhi 2018 Dec;47(12):941-944

Department of Pathology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To investigate the clinicopathological features of gangliocytic paraganglioma(GP). Clinical data and pathological diagnosis of the 4 cases of GP were obtained through the medical record inquiry from January 2011 to December 2017 at the First Affiliated Hospital of Zhengzhou University. Routine HE staining and immunohistochemistry of CKpan, Syn, CgA, CD56, NSE and NF were performed. Read More

Rev Bras Parasitol Vet 2018 Dec 10. Epub 2018 Dec 10.

Laboratório AQUOS - Sanidade de Organismos Aquáticos, Departamento de Aquicultura, Universidade Federal de Santa Catarina - UFSC, Florianópolis, SC, Brasil.

The capsalid monogenean Neobenedenia melleni is known as a lethal pathogen for captured marine teleost ornamental fish, if left untreated. This study reports the occurrence of N. melleni parasitizing four species of ornamental reef fish imported into Brazil and maintained in quarantine: Arabian angelfish (Pomacanthus asfur ), yellowbar angelfish (Pomacanthus maculosus), regal angelfish (Pygoplites diacanthus), and bluecheek butterflyfish (Chaetodon semilarvatus). Read More

Arq Gastroenterol 2018 Jul-Sep;55(3):290-295

Universidade do Estado da Bahia, Departamento de Ciências da Vida, Salvador, BA, Brasil.

Background: The diagnosis of inflammatory bowel disease is often delayed because of the lack of an ability to recognize its major clinical manifestations.

Objective: Our study aimed to describe the onset of clinical manifestations in inflammatory bowel disease patients.

Methods: A cross-sectional study. Read More

J Parasit Dis 2018 Dec 15;42(4):643-645. Epub 2018 Oct 15.

2Veterinary Clinical Complex, Lala Lajpat Rai University of Veterinary and Animal Sciences (LUVAS), Hisar, Haryana India.

A 5 years old crossbred cow was brought to the Veterinary Clinical Complex of Lala Lajpat Rai University of Veterinary and Animal Sciences Hisar with history of progressive weakness, pale mucous membrane, anorexia, high fever (105 °F), tachycardia, laboured breathing and coffee coloured urine. Analysis of haematological parameters revealed severe anaemia, leucocytopenia, marked poikilocytosis of erythrocytes. Blood smear examination showed presence of signet ring shaped organisms, piroplasms and condensed dot forms of in the stained erythrocytes. Read More

J Prosthodont 2018 Dec 10. Epub 2018 Dec 10.

Department of Pharmaceutical and Biomedical Sciences, Touro College of Pharmacy, New York, NY.

Purpose: Denture stomatitis is a common condition manifested by inflammation of the oral mucous membrane beneath a denture. The objective of this study was to compare the transcriptome of human palatal mucosa with chronic oral stomatitis-associated Candida albicans infection to that of healthy oral mucosa.

Materials And Methods: Oral palatal biopsies were obtained from 17 healthy and 15 C. Read More

J Aquat Anim Health 2018 Dec 7. Epub 2018 Dec 7.

Department of Clinical Oral Biology, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

In September 2016, a marine fish farm operator in Selangor, Malaysia reported a disease outbreak affecting juvenile Hybrid Groupers (Camouflage Grouper Epinephelus polyphekadion x Tiger Grouper E. fuscoguttatus). The average daily mortality was 120 fish, resulting in a cumulative mortality rate of 29% within 10 days. Read More

Z Geburtshilfe Neonatol 2018 Dec 10;222(6):262-265. Epub 2018 Dec 10.

Obstetrics and Gynecology, Necmettin Erbakan Universitesi Meram Tip Fakultesi, Konya, Turkey.

A foetal sublingual cystic lesion was diagnosed by routine prenatal ultrasonography at 27 weeks of gestation. Foetal growth and amniotic fluid volume were normal. An ex utero intrapartum treatment (EXIT) procedure was performed, and the cyst was aspirated to allow breathing during planned Caesarean section. Read More

Methods Mol Biol 2019 ;1916:297-301

Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo, Diadema, SP, Brazil.

Asthma is a worldwide public health issue, affecting the sufferer's quality of life. Many researchers are extensively studying the cellular processes involved in the affected airways. Experimental asthma using animals has been performed for a long time, mainly applying murine models due to well-known advantages. Read More

Rev Chilena Infectol 2018 Aug;35(4):403-412

Departamento de Epidemiología, División de Planificación Sanitaria, Ministerio de Salud de Chile, Chile.

Gonorrhea is produced by the bacterium Neisseria gonorrhoeae, which is capable of infecting different types of mucous membranes depending on sexual practices. It is located preferably in the man's urethra and in the woman's cervix, also in the rectum and pharynx. Its main form of transmission is through unprotected sex and, occasionally, through the birth canal in newborns. Read More

Front Microbiol 2018 23;9:2796. Epub 2018 Nov 23.

Lehrstuhl für Technische Mikrobiologie, Technische Universität München, Freising, Germany.

belongs to the dominating lactic acid bacteria in indigenous meat fermentations, while diverse strains of this species have also been isolated from plant fermentations. We could recently show, that TMW 1.411 produces a high molecular weight dextran from sucrose, indicating its potential use as a dextran forming starter culture. Read More

Vet World 2018 Nov 22;11(10):1473-1478. Epub 2018 Oct 22.

Department of Agrobiotechnology, Agrarian Technological Institute, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.

Aim: The purpose of this work was to study the dynamics of structural manifestations of acute cases of postpartum endometritis in cows.

Materials And Methods: The light and electron microscopy methods were used when studying structural changes in the endometrium in case of postpartum endometritis in seven cows. Sections of endometrial specimens for light microscopy, 5-7 µm thick, were stained with hematoxylin and eosin and also by Van Gieson's. Read More

J Immunol 2018 Dec 7. Epub 2018 Dec 7.

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229;

Regulation of the intestinal mucus layer by goblet cells is important for preventing inflammation and controlling infection. IL-33, a cytokine upregulated in inflammatory bowel disease and helminth infection, induces intestinal goblet cells, but the mechanism remains unclear. Enteroids are three-dimensional structures of primary small intestinal epithelial cells that contain all differentiated intestinal epithelial cell types. Read More

Ecotoxicol Environ Saf 2018 Dec 4;170:62-67. Epub 2018 Dec 4.

Department of Biological Sciences, University of Lethbridge, Lethbridge AB T1K 3M4, Canada.

Oil sands process-affected water (OSPW), a byproduct of the extraction of bitumen in the surface mining of oil sands, is currently stored in massive on-site tailings ponds. Determining the potential effects of OSPW on aquatic ecosystems is of main concern to oil sands companies and legislators concerned about the reclamation of mining sites. In the present study, the interaction of OSPW with the chemosensory system of rainbow trout was studied. Read More

J Theor Biol 2018 Dec 7. Epub 2018 Dec 7.

MaIAGE, INRA, Paris-Saclay University, Jouy-en-Josas, France.

The gut microbiota, mainly located in the colon, is engaged in a complex dialogue with the large intestinal epithelium through which important regulatory processes for the health and well-being of the host take place. Imbalances of the microbial populations, called dysbiosis, are related to several pathological status, emphasizing the importance of understanding the gut bacterial ecology. Among the ecological drivers of the microbiota, the spatial structure of the colon is of special interest: spatio-temporal mechanisms can lead to the constitution of spatial interactions among the bacterial populations and of environmental niches that impact the overall colonization of the colon. Read More

J Control Release 2018 Dec 6. Epub 2018 Dec 6.

Department of Chemical Engineering, Northeastern University, 360 Huntington Avenue, Boston, MA 02110, United States. Electronic address:

The utilization of polymers to stabilize drug supersaturation and enhance oral drug absorption has recently garnered considerable interest. The potential role of intestinal mucus in stabilizing drug supersaturation, however, has not been previously explored. The ability for intestinal mucus to stabilize drug supersaturation and delay drug precipitation is potentially useful in enhancing the absorption of orally dosed compounds from drug delivery systems that generate supersaturation within the gastrointestinal tract (e. Read More

Future Microbiol 2018 Dec 11. Epub 2018 Dec 11.

Ningbo Dairy Group, Ningbo, 315211, Zhejiang, PR China.

Aim: The role of mucus-binding protein (MUB) on the adhesion activity and immunomodulatory effect of Lactobacillus acidophilus.

Materials & Methods: The current research mainly focuses on the adhesion and immune function of MUB from L. acidophilus. Read More

J Agric Food Chem 2018 Dec 7. Epub 2018 Dec 7.

The livestock industry in the western United States loses an estimated $500 million annually from livestock production losses due to poisonous plants. Poisoning of livestock by plants often goes undiagnosed because there is a lack of appropriate or available specimens for analysis. Lupinus species represent an important toxic plant in western North America that can be toxic and/or teratogenic to livestock species due to the quinolizidine alkaloids. Read More

Fish Shellfish Immunol 2018 Dec 3;86:688-694. Epub 2018 Dec 3.

Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address:

The present study aimed at evaluation of possible effects of Psidium guajava as immunostimulant on mucosal and serum immunity, as well as related genes expression in common carp (Cyprinus carpio) fingerlings. In an eight weeks feeding trial, fish were fed with experimental diets containing guava leaf powder [GLP] (0, 0.25, 0. Read More

J Fish Dis 2018 Dec 6. Epub 2018 Dec 6.

Fish Disease Research Unit, University of Veterinary Medicine, Hannover, Germany.

Aeromonas spp. are ubiquitous in the aquatic environment, acting as facultative or obligate pathogens for fish. Identifying Aeromonas spp. Read More

Chin J Integr Med 2018 Dec 5. Epub 2018 Dec 5.

Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Objective: To evaluate the involvement of different CD4 T cell subtypes in the anti-asthmatic effects of acupuncture in asthmatic mice.

Methods: BALB/c mice were challenged by ovalbumin (OVA) for the establishment of experimental asthma model. Mice were divided into 4 groups by a random number table including the normal control, asthma model, acupuncture and sham acupuncture groups (14 per group). Read More

Hautarzt 2018 Dec 5. Epub 2018 Dec 5.

Klinik für Dermatologie, Allergologie und Venerologie, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Autoimmmune bullous diseases are mediated by pathogenetically relevant autoantibodies against components of the epidermis and/or superficial mucous membranes (in pemphigus) and structural proteins of the dermal-epidermal junction (in pemphigoid diseases). Using immunoadsorption (IA), an already well-established procedure in cardiac and rheumatic disorders, antibodies can be removed from the plasma. At present, most data on the adjuvant use of IA in dermatology are derived from patients with severe and/or refractory pemphigus vulgaris or pemphigus foliaceus and also from patients with pemphigoid diseases. Read More

Respirol Case Rep 2019 Feb 28;7(2):e00392. Epub 2018 Nov 28.

Department of Respiratory Medicine National Center for Global Health and Medicine Tokyo Japan.

Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma. A 35-year-old woman with uncontrolled severe asthma despite maximal pharmacological treatment underwent BT and started coughing after the first procedure. One month later, during the second BT procedure, there were white ulcerous lesions on the right B9 bronchus. Read More

J Venom Anim Toxins Incl Trop Dis 2018 29;24:36. Epub 2018 Nov 29.

2Laboratory of genetics - LABGEN, Institute of Genetics and Biochemistry, Campus Umuarama, Federal University of Uberlândia, Avenida Pará, Uberlândia, MG 1720 Brazil.

Background: Animal poisons and venoms are sources of biomolecules naturally selected. toads are widespread in the whole Brazilian territory and they have poison glands and mucous gland. Recently, protein from toads' secretion has gaining attention. Read More

Sci Rep 2018 Dec 5;8(1):17665. Epub 2018 Dec 5.

Department of Morphology, Surgery, Experimental Medicine and LTTA Centre, University of Ferrara, via Fossato di Mortara 70, 44121, Ferrara, Italy.

Snail mucus is a mixture of active substances commonly thought to have healthy properties for the treatment of skin disorders. Although snail mucus is an ingredient of several cosmetic and para-pharmaceutic products, a comprehensive characterization of chemical composition and biological effects is still missing. Crude purified extracts from Helix aspersa muller mucus (HelixComplex) were prepared and, after chemical characterization, tested on in vitro experimental models. Read More

Methods Mol Biol 2019 ;1885:221-231

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Cystic fibrosis (CF) is an inherited disease characterized by the accumulation of thick, sticky mucus which damages epithelia in organs such as the lungs, pancreas, liver, intestines, and other parts of the body. The most common symptoms are sinopulmonary disease and chronic gastrointestinal tract problems resulting from decreased mucociliary clearance and inflammation. CF is the most common life-limiting autosomal recessive disorder in people of northern European ancestry and it affects other populations with different prevalence. Read More

Clin Rev Allergy Immunol 2018 Nov 30. Epub 2018 Nov 30.

Department of Respiratory Medicine & Allergology, Inst for Clinical Science, Lund University, Lund, Sweden.

Improving the lung function after experimental allergen challenge by blocking of mast cell (MC) mediators and the capability of MC mediators (including histamine, prostaglandin (PG) D2, and leukotriene (LT) C4) in induction of mucosal edema, bronchoconstriction, and mucus secretion provide evidence that MCs play a key role in pathophysiology of asthma. In asthma, the number of MCs increases in the airways and infiltration of MCs in a variety of anatomical sites including the epithelium, the submucosal glands, and the smooth muscle bundles occurs. MC localization within the ASM is accompanied with the hypertrophy and hyperplasia of the layer, and smooth muscle dysfunction that is mainly observed in forms of bronchial hyperresponsiveness, and variable airflow obstruction. Read More

World J Otorhinolaryngol Head Neck Surg 2018 Sep 1;4(3):175-178. Epub 2018 Nov 1.

Friedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Otorhinolaryngology, Head and Neck Surgery, Waldstrasse 1, 91054, Erlangen, Germany.

The objective of this manuscripts to review current knowledge regarding exosomes as they relate to the physiology and pathology of the human nose as well as their role as biomarkers of chronic rhinosinusitis with nasal polyps (CRSwNP). Exosomes are 30-150 nm membrane-bound vesicles secreted by virtually all cell types. Exosomes contribute to the rapid inter-epithelial transfer of proteins and mediate innate immunosurveillance and defense mechanisms in the human nasal cavity. Read More

Indian Dermatol Online J 2018 Nov-Dec;9(6):422-425

Department of Dermatology, Venereology, and Leprosy, Gandhi Medical College, Hyderabad, Telangana, India.

Background: Pemphigus disorders are a group of immunobullous diseases affecting skin and/or mucus membranes. Dexamethasone cyclophosphamide pulse (DCP)/dexamethasone only pulse (DOP) therapy has shown promising results in the management of pemphigus group of diseases in adults.

Aim: To evaluate the outcome of pulse therapy (PT) in pediatric cases diagnosed with pemphigus vulgaris (PV). Read More

Sci Rep 2018 Nov 30;8(1):17503. Epub 2018 Nov 30.

Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden.

The DNA sequence of the two human mucin genes MUC2 and MUC6 have not been completely resolved due to the repetitive nature of their central exon coding for Proline, Threonine and Serine rich sequences. The exact nucleotide sequence of these exons has remained unknown for a long time due to limitations in traditional sequencing techniques. These are still very poorly covered in new whole genome sequencing projects with the corresponding protein sequences partly missing. Read More