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Oncol Lett 2019 Mar 28;17(3):3382-3386. Epub 2019 Jan 28.

Department of Cardiothoracic Surgery, Suizhou Central Hospital, Suizhou, Hubei 441300, P.R. China.

The present study explored the significance of programmed death-ligand 1 (PD-L1) molecules in the diagnosis and treatment of B-cell malignant lymphoma. A total of 92 patients with B-cell malignant lymphoma (experimental group), admitted to the Quanzhou First Hospital Affiliated to Fujian Medical University from February 2014 to May 2017, and 60 healthy subjects (control group) were enrolled in this study and their clinical data were retrospectively analyzed. Plasma levels of PD-L1 before treatment and at 5, 10, and 15 days after treatment were measured by ELISA. Read More

Ophthalmic Plast Reconstr Surg 2019 Mar 8. Epub 2019 Mar 8.

The Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.

Large cysts in the orbital lobe of the lacrimal gland are rare and are associated with Sjögren syndrome and B-cell mucosa-associated lymphoid tissue lymphoma. The authors describe 4 new cases of large orbital lobe lacrimal gland cysts. The first 2 patients, both with Sjögren syndrome, had unilateral cysts associated with chronic inflammation. Read More

Eur J Ophthalmol 2019 Mar 12:1120672119837085. Epub 2019 Mar 12.

2 Department of Ophthalmology, Gazi University Medical School, Ankara, Turkey.

Primary non-Hodgkin lymphoma (NHL) of lacrimal drainage system (LDS) is quite rare in children, but it is important to expedite early diagnosis in an effort to alter possible life-threatening disease since they are usually misdiagnosed as chronic dacryocystitis. In the literature, there are few examples of tumors of LDS in children. The authors herein report two pediatric cases of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) originating from lacrimal sac in an attempt to increase the knowledge about the clinical course of NHL of LDS. Read More

Mol Imaging Biol 2019 Mar 7. Epub 2019 Mar 7.

Department of Medicine I, Medical University of Vienna, Vienna, Austria.

Purpose: Standardized uptake values (SUV), total metabolic tumor volumes (TMTV), and total lesion glycolysis (TLG) based on positron emission tomography with 2-deoxy-2-[F]fluoro-D-glucose ([F]FDG/positron emission tomography (PET) are established outcome predictors in FDG-avid lymphomas. We therefore investigated whether these biomarkers also have prognostic value in extranodal marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma), with a focus on patients treated with anti-CD20 antibody-based immunotherapy.

Procedures: Pre-therapeutic [F]FDG/PET scans of 61 treatment-naïve MALT lymphoma patients, including 35 scheduled for anti-CD20 antibody-based immunotherapy, were included in this retrospective study. Read More

Mucosal Immunol 2019 Mar 7. Epub 2019 Mar 7.

Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, 41390, Sweden.

Helicobacter suis is the most prevalent non-Helicobacter pylori Helicobacter species in the human stomach and is associated with chronic gastritis, peptic ulcer disease, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. H. suis colonizes the gastric mucosa of 60-95% of pigs at slaughter age, and is associated with chronic gastritis, decreased weight gain, and ulcers. Read More

Rheumatology (Oxford) 2019 Mar 5. Epub 2019 Mar 5.

Department of Rheumatology, Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Centre for Immunology of Viral Infections and Autoimmune Diseases, INSERM UMR1184, Le Kremlin Bicêtre, France.

Lymphoma development is the most serious complication of SS and the main factor impacting on mortality rate in patients with this condition. Lymphomas in SS are most commonly extranodal non-Hodgkin B-cell lymphomas of the mucosa-associated lymphoid tissue and frequently arise in salivary glands that are the target of a chronic inflammatory autoimmune process. Extensive work on lymphomagenesis in SS has established that the progression towards B-cell lymphoma is a multistep process related to local chronic antigenic stimulation of B cells. Read More

Hinyokika Kiyo 2018 Dec;64(12):489-495

The Department of Urology, Faculty of Medicine, University of Tsukuba.

A 78-year-old man was referred to Tsukuba University Hospital for right hydronephrosis. He had undergone ureteroscopy and ureteral stenting in another hospital, but no tumor was revealed in renal pelvis and ureter. The urinary cytology was negative. Read More

Intern Med J 2019 Feb 28. Epub 2019 Feb 28.

Division of Cancer Services, Clinical Haematology, Princess Alexandra Hospital, Brisbane, QLD.

Mantle cell lymphoma (MCL) and the marginal zone lymphoma (MZL) subtypes (nodal MZL, extra-nodal MZL of mucosa-associated lymphoid tissue (MALT lymphoma) and splenic MZL) are uncommon lymphoma subtypes, accounting for less than 5-10% of all non-Hodgkin lymphoma. The evidence base for therapy is therefore limited and enrolment into clinical trials is preferred. Outcomes for patients with MCL have been steadily improving mainly due to the adoption of more intense strategies in younger patients, the use of rituximab maintenance and the recent introduction of bendamustine in older patients. Read More

Am J Hematol 2019 Feb 19. Epub 2019 Feb 19.

Division of Hematology, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida.

Between 11 and 37% of extranodal marginal zone lymphoma (EMZL) patients present with disease involvement in multiple mucosal sites (MMS). We analyzed 405 EMZL patients seen between 1995 and 2017: 265 (65.4%) patients presented with stage I disease, 49 of 309 (15. Read More

Cell Mol Life Sci 2019 Feb 19. Epub 2019 Feb 19.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527, Athens, Greece.

Helicobacter pylori (H. pylori) infection affects an estimated 4.4 billion people globally. Read More

BMC Pediatr 2019 Feb 19;19(1):63. Epub 2019 Feb 19.

Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, 80756, Taiwan.

Background: Primary lymphomas of the gastrointestinal tract are rare, accounting for only 1 to 4% of malignancies arising in the stomach, small intestine, or colon. The stomach is the most common extranodal site of lymphoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma accounts for 40% of primary gastric lymphoma. Gastric MALT lymphoma reaches its peak incidence between 50 to 60 years of age, therefore, it is rarely encountered in pediatric population. Read More

Int J Surg Pathol 2019 Feb 17:1066896919830498. Epub 2019 Feb 17.

2 Dubai Hospital, Dubai, United Arab Emirates.

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):165-170

Department of Endocrinology, Peking University First Hospital, Beijing 100034, China.

Objective: To discuss the clinical characteristics and diagnostic and therapeutic considerations of primary thyroid lymphoma (PTL) by reviewing PTL cases.

Methods: In the study, 12 cases of PTL diagnosed and treated in Peking University First Hospital between January 1995 and September 2015 were identified. The clinical characteristics, management experiences and prognosis of these cases were reviewed retrospectively. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):35-42

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To investigate the clinicopathological features and prognostic factors in lymphoma of parotid origin.

Methods: Clinicopathological data of the patients with parotid lymphoma who were initially diagnosed in Peking University Hospital of Stomatology from 2006 to 2016 were collected and analyzed retrospectively. The patients were followed-up for 5 to 149 months with a median period of 45 months, and the factors influencing the prognosis were evaluated. Read More

Int J Radiat Oncol Biol Phys 2019 Feb 12. Epub 2019 Feb 12.

Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Purpose/objectives: In patients with gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue lymphoma (MALT lymphoma), the standard radiation therapy (RT) dose is ≥ 30 Gy. We report the outcome of patients treated with reduced 24 Gy compared with ≥ 30 Gy.

Materials/methods: We reviewed 32 patients diagnosed between 2007 and 2017 with gastric MALT lymphoma and treated with involved site radiation therapy (ISRT) using intensity modulated radiation therapy (IMRT). Read More

Minerva Gastroenterol Dietol 2019 Feb 12. Epub 2019 Feb 12.

Unit of Dietetics and Clinical Nutrition, Città della Salute e della Scienza, Turin, Italy.

Helicobacter pylori (HP) is a gram negative flagellated pathogen acid-resistant bacterium; it belongs to the order Campylobacterales that is wide spread all over the world, infecting more than 50% of the world population. HP infection is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and with 3 to 6-fold increased relative risk for developing gastric adenocarcinoma and mucosa-associated lymphoid tissue (MA LT) lymphoma. For this reason HP is recognized by the World Health Organization as a Class I human carcinogen. Read More

Arch Pathol Lab Med 2019 Feb 6. Epub 2019 Feb 6.

and the Department of Pathology, University of Texas Southwestern Biocenter, Dallas (Dr Rosado).

Pulmonary nodular lymphoid hyperplasia is an uncommon reactive lymphoproliferative disorder that presents as an asymptomatic lung mass. The histopathologic diagnosis of pulmonary nodular lymphoid hyperplasia may be challenging because of its morphologic overlap with other diseases, such as extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue and immunoglobulin G4-related sclerosing disease. Despite the similarities, there are distinctive morphologic and phenotypic features that allow for the correct diagnosis in the majority of cases. Read More

Vet Immunol Immunopathol 2019 Feb 18;208:1-5. Epub 2018 Dec 18.

Centre for Animal Biotechnology, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Victoria, 3010, Australia. Electronic address:

M cells play a pivotal role in the induction of immune responses within the mucosa-associated lymphoid tissues. M cells exist principally in the follicle-associated epithelium (FAE) of the isolated solitary lymphoid follicles as well as in the lymphoid follicles of nasopharynx-associated lymphoid tissue and gut associated lymphoid tissue (GALT). Through lymphatic cannulation it is possible to investigate local immune responses induced following nasal Ag delivery in sheep. Read More

Br J Ophthalmol 2019 Feb 1. Epub 2019 Feb 1.

Department of Ophthalmology and Visual Science, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

Purpose: To report the clinical manifestations of 199 patients with suspected conjunctival lymphoma, the associations between these features and the pathological diagnoses, and the prognosis of conjunctival lesions during long-term follow-up.

Methods: We conducted a retrospective chart review of 199 patients who underwent conjunctival biopsy on suspicion of conjunctival lymphoproliferative disease between January 2008 and June 2015. We focused on slit-lamp findings in the conjunctiva and the pathological diagnoses. Read More

Arch Craniofac Surg 2019 Feb 1;20(1):66-70. Epub 2019 Feb 1.

Department of Plastic and Reconstructive Surgery, Wonkwang University Hospital, Iksan, Korea.

Mucosa-associated lymphoid tissue (MALT) lymphoma is an uncommon form of non-Hodgkin lymphoma involving the mucosa-associated lymphoid tissue. Most commonly affected organ is the stomach. But, it could affect almost every organ in the whole body. Read More

Medicine (Baltimore) 2019 Feb;98(5):e14270

Department of Nuclear Medicine, Lanzhou University Second Hospital, Lanzhou University.

Rationale: Mucosa-associated lymphoid tissue (MALT) lymphoma is an extranodal low-grade B cell lymphoma that generally exhibits an indolent clinical course. Currently, the application of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in MALT lymphoma is still controversial. Herein, we reported a case of using F-FDG PET/CT for staging and response assessment of primary parotid MALT lymphoma with multiple sites involvement. Read More

Australas J Dermatol 2019 Jan 29. Epub 2019 Jan 29.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.

Gan To Kagaku Ryoho 2018 Dec;45(13):2282-2284

Dept. of General Surgery, Shuuwa General Hospital.

A 62-year-old man presented with complaints of acute abdominal pain. Abdominal enhanced CT showed free air in the abdominal cavity, a thickened stomach wall accompanied by deep ulcer, and enlarged lymph nodes around the stomach. Emergent surgery was conducted, and a perforation in the upper part of the stomach was found. Read More

Korean J Gastroenterol 2019 Jan;73(1):19-25

Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.

Background/aims: The eradication of () is an effective treatment in gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated with infection. However, the treatment strategy in gastric MALT lymphoma patients who are -negative or unresponsive to eradication therapy remains controversial. In this study, we investigated the clinical efficacy of treatments other than eradication therapy in these groups of patients. Read More

Clin Lymphoma Myeloma Leuk 2019 Jan 3. Epub 2019 Jan 3.

Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Introduction: We report our experience in treating patients with primary breast extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) to better elucidate the natural history and optimal treatment approach for these patients.

Patients And Methods: Patients with localized primary breast MALT lymphoma treated between 1995 and 2016 were included. Disease-related endpoints including progression-free survival (PFS) were analyzed. Read More

Cancers (Basel) 2019 Jan 19;11(1). Epub 2019 Jan 19.

Healthcare Department, Hitachi Systems, Ltd. 1-2-1 Osaki, Shinagawa-ku, Tokyo 141-8672, Japan.

Eradication of Helicobacter pylori (H. pylori) is an effective strategy for preventing various gastrointestinal diseases such as gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma. However, the eradication success rate is decreasing because of a recent increase in drug-resistant strains of H. Read More

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):45-49

Departments of Pathological Diagnostics, Yamagata City Hospital SAISEIKAN.

A 72-year-old woman underwent computed tomography (CT) to identify the underlying cause of thrombocytosis. The CT showed a bladder tumor. Urine cytology was negative. Read More

Case Rep Gastrointest Med 2018 9;2018:3607101. Epub 2018 Dec 9.

Thomas Jefferson University, Philadelphia, PA, USA.

Colonic MALToma accounts for 2.5% of all MALTomas. MALToma can be associated with certain chronic infections, autoimmune disorders, Waldenstrom's macroglobulinemia, and old age. Read More

Case Rep Gastroenterol 2018 Sep-Dec;12(3):699-703. Epub 2018 Nov 28.

Department of Pathology, University of Toyama, Toyama, Japan.

According to the literature, spontaneous remission of aggressive lymphomas is extremely rare; gastric non-Hodgkin lymphomas, such as mucosa-associated lymphoid tissue lymphomas, often regress due to treatment or no progression, even in a watch-and-wait strategy. Although spontaneous remission of diffuse large B cell lymphomas in the stomach was very rarely reported, the follow-up periods of the cases of spontaneous remission are within 2 years and most cases are likely to relapse after the first remission. Here, we report that a diffuse large B cell lymphoma in the stomach showed spontaneous remission within 2 months after the initial diagnosis and the remission is still continuing for 10 years without any specific treatments against this aggressive lymphoma. Read More

Radiat Oncol J 2018 Dec 31;36(4):332-340. Epub 2018 Dec 31.

Department of Radiation Oncology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Purpose: To retrospectively analyze dosimetric parameters of volumetric-modulated arc therapy (VMAT) and three-dimensional conformal radiotherapy (3D-CRT) delivered to extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue in the stomach (gastric MALT lymphoma) to find out advantages of VMAT and conditions for definite benefits of VMAT.

Materials And Methods: Fifty patients with stage I-II gastric MALT lymphoma received VMAT (n = 14) or 3D-CRT (n = 36) between December 2005 and April 2018. Twenty-seven patients were categorized according to whether the planning target volume (PTV) overlaps kidney(s). Read More

Rinsho Ketsueki 2018 ;59(12):2600-2605

Department of Hematology, Chiba University Hospital.

A 60-year-old man with chronic hepatitis C was referred to our hospital with significantly elevated total protein and serum IgM (9,500 mg/dl) levels identified via a routine checkup. Blood examination revealed increased serum IgM-monoclonal protein and serum-soluble IL-2 receptor (sIL2R) levels. Computed tomography and fluorodeoxyglucose positron emission tomography revealed pulmonary masses, abnormal soft tissue masses surrounding the bilateral kidneys, and thickened mucous membrane of the bladder with high fluorodeoxyglucose uptake. Read More

J Thorac Dis 2018 Nov;10(11):6040-6049

Department of Radiology, Shanghai Oriental Hospital Affiliated Tongji University, Shanghai 200120, China.

Background: Primary pulmonary lymphoma (PPL) mainly comprises mucosa-associated lymphoid tissue (MALT) lymphoma as well as other subtypes of lymphoma. Different phenotypes of PPL demonstrate various high-resolution computed tomography (HRCT) features. We aimed to evaluate the value of HRCT in the diagnosis and differential diagnosis of PPL, especially between MALT lymphoma and non-MALT lymphoma and the correlation between CT and pathological features. Read More

Int J Hematol 2019 Mar 3;109(3):247-248. Epub 2019 Jan 3.

Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, 849-8501, Japan.

Respir Med Case Rep 2019 15;26:150-153. Epub 2018 Dec 15.

Department of Pathology, Basic Medical Sciences of Wuhan University, Wuhan, Hubei, PR China.

Primary pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is extremely rare. MALT lymphoma patients usually show no clinical symptoms or physical signs. Chest radiograph or computed tomography (CT) may confuse MALT lymphoma with other pulmonary diseases, which would lead to misdiagnosis or a delayed diagnosis. Read More

Ann Gastroenterol 2019 Jan-Feb;32(1):110. Epub 2018 Nov 2.

Department of Gastroenterology, National Hospital Organization Fukuyama Medical Center, Fukuyama, Japan.

Lung Cancer 2019 Mar 18;129:107-109. Epub 2018 Dec 18.

Department of Molecular and Internal Medicine, Institute of Biomedical & Health Sciences, Hiroshima University, Minami-ku, Hiroshima, Japan.

Blood Res 2018 Dec 17;53(4):329-332. Epub 2018 Dec 17.

Department of Pathology, Chungnam National University School of Medicine, Daejeon, Korea.

Blood Res 2018 Dec 17;53(4):307-313. Epub 2018 Dec 17.

Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: Primary ocular adnexal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (POML) is the most common subtype of lymphoma involving the eyes in Thailand. We sought to assess the characteristics and treatment outcomes of patients with POML in Thailand.

Methods: We retrospectively reviewed patient data and included patients diagnosed with POML between January 2004 and December 2016 at Chiang Mai University Hospital and King Chulalongkorn Memorial Hospital, Thailand. Read More

Cent Eur J Immunol 2018 30;43(3):335-340. Epub 2018 Oct 30.

Department of Microbiology, Faculty of Biology, University of Szczecin, Szczecin, Poland.

The fish immune system is extremely complex and has considerable adaptive potential. In Osteichthyes, the system is formed by lymphopoietic organs which are important for the differentiation and maturation of the immune system cells. These organs include the anterior kidney (phronephros), the thymus, the spleen, the posterior kidney (mesonephros), and mucosa-associated lymphoid tissues (MALT). Read More

Respir Med Case Rep 2019 8;26:101-104. Epub 2018 Dec 8.

Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, 430-0906 2-12-12, Sumiyoshi Naka-ku, Hamamatsu-city, Shizuoka, Japan.

A 61-year-old woman with a history of palpebral conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma, treated with rituximab, was referred to the authors' hospital after follow-up positron emission tomography/computed tomography revealed F-fluoro-2-deoxy-d-glucose uptake in a tumor located in the left main bronchus. The diagnosis of MALT lymphoma was made by pathological and immunohistochemical findings homologous to previous palpebral conjunctival lesion via bronchoscopic biopsy. The disease was controlled with rituximab, cyclophosphamide, oncovin, and prednisolone (i. Read More

Med Sci Monit Basic Res 2018 Dec 24;24:233-240. Epub 2018 Dec 24.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China (mainland).

BACKGROUND Primary pulmonary mucosa-associated lymphoma tissue lymphoma is rare and is often misdiagnosed because of its diverse and nonspecific clinical features. The aim of this study was to raise awareness among clinicians and to share our experience of treating and managing such patients. MATERIAL AND METHODS This retrospective study was conducted between 1 January 2009 and 31 October 2017 at the First Affiliated Hospital of Guangxi Medical University. Read More

Onco Targets Ther 2018 10;11:8937-8942. Epub 2018 Dec 10.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,

Gastrointestinal stromal tumor (GIST) is an uncommon mesenchymal tumor, and has been shown to be associated with synchronous or metachronous second malignancies. Rare cases of coincident GIST and non-Hodgkin lymphomas (NHL) have been reported previously. Here, we report two cases of GIST and coincident primary breast lymphoma, an uncommon subtype of extranodal NHL. Read More

J Virol 2018 Dec 12. Epub 2018 Dec 12.

German Cancer Research Centre (DKFZ) Unit F100, Heidelberg, Germany

The Epstein-Barr virus (EBV) infects the oropharynx but surprisingly frequently induces B-cell proliferations in the gut of immunosuppressed individuals. We found that EBV infection induces the expression of the LPAM-1 integrin on tonsillar B cells and increases it on peripheral blood cells. Similarly, LPAM-1 was induced in the tonsils of patients undergoing primary infectious mononucleosis. Read More

Cesk Slov Oftalmol 2018 ;73(5-6):211-217

Introduction: Lymphoma is a malignant disease that can affect several structures of the orbit and eye adnexa. In the area of orbit the non-Hodgkins lymphoma (NHL) is typical, which may be indolent or aggressive. Indolent subtypes include MALT (mucosa-associated lymphoid tissue), follicular lymphoma (FL), lymphoplasmocytic lymphoma (LPL). Read More

Methods Mol Biol 2019 ;1901:103-112

UCLA School of Dentistry, Los Angeles, CA, USA.

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease marked by dry mouth/dry eye symptoms as a result of the destruction of the salivary and lacrimal glands. Patients with pSS may be at risk for the development of mucosa-associated lymphoid tissue (MALT) lymphoma. Testing of autoantibodies in the oral fluid of patients with pSS or MALT lymphoma using immunoassays may lead to a simple and noninvasive clinical tool for diagnostic or prognostic applications. Read More

Vet Immunol Immunopathol 2018 Dec 13;206:9-15. Epub 2018 Nov 13.

Applied Veterinary Morphology, Department of Veterinary Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium; Department of Morphology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium. Electronic address:

Selection for prolificacy in modern pig farming has resulted in increasing litter sizes. Since rearing large litters is challenging, artificial rearing of piglets with a milk replacer is an alternative strategy. It is hypothesized that the development of the piglets' mucosa-associated lymphoid tissues (MALT) is affected by these artificial conditions. Read More

Molecules 2018 Nov 30;23(12). Epub 2018 Nov 30.

Unit of Molecular Signal Transduction in Inflammation, VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium.

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an intracellular cysteine protease (paracaspase) that plays an integral role in innate and adaptive immunity. The phenothiazine mepazine has been shown to inhibit the proteolytic activity of MALT1 and is frequently used to study its biological role. MALT1 has recently been suggested as a therapeutic target in rheumatoid arthritis. Read More

Int Urogynecol J 2018 Dec 3. Epub 2018 Dec 3.

Department of Urology, Tan Tock Seng Hospital, Singapore, Singapore.

Ann Hematol 2018 Nov 28. Epub 2018 Nov 28.

Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.