5,186 results match your criteria Mucosa-Associated Lymphoid Tissue


Determination of Autoantibodies to Salivary Gland Antigens.

Methods Mol Biol 2019 ;1901:103-112

UCLA School of Dentistry, Los Angeles, CA, USA.

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease marked by dry mouth/dry eye symptoms as a result of the destruction of the salivary and lacrimal glands. Patients with pSS may be at risk for the development of mucosa-associated lymphoid tissue (MALT) lymphoma. Testing of autoantibodies in the oral fluid of patients with pSS or MALT lymphoma using immunoassays may lead to a simple and noninvasive clinical tool for diagnostic or prognostic applications. Read More

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January 2019

The porcine tonsils and Peyer's patches: A stereological morphometric analysis in conventionally and artificially reared piglets.

Vet Immunol Immunopathol 2018 Dec 13;206:9-15. Epub 2018 Nov 13.

Applied Veterinary Morphology, Department of Veterinary Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium; Department of Morphology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium. Electronic address:

Selection for prolificacy in modern pig farming has resulted in increasing litter sizes. Since rearing large litters is challenging, artificial rearing of piglets with a milk replacer is an alternative strategy. It is hypothesized that the development of the piglets' mucosa-associated lymphoid tissues (MALT) is affected by these artificial conditions. Read More

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December 2018
1 Read

Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function.

Molecules 2018 Nov 30;23(12). Epub 2018 Nov 30.

Unit of Molecular Signal Transduction in Inflammation, VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium.

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an intracellular cysteine protease (paracaspase) that plays an integral role in innate and adaptive immunity. The phenothiazine mepazine has been shown to inhibit the proteolytic activity of MALT1 and is frequently used to study its biological role. MALT1 has recently been suggested as a therapeutic target in rheumatoid arthritis. Read More

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November 2018
3 Reads

An uncommon case of mucosa-associated lymphoid tissue (MALT) tumor of the bladder.

Int Urogynecol J 2018 Dec 3. Epub 2018 Dec 3.

Department of Urology, Tan Tock Seng Hospital, Singapore, Singapore.

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December 2018
2 Reads

Asymmetric lacrimal gland enlargement: an indicator for detection of pathological entities other than thyroid eye disease.

Graefes Arch Clin Exp Ophthalmol 2018 Nov 28. Epub 2018 Nov 28.

Department of Oculoplastic, Orbital, and Lacrimal Surgery, Aichi Medical University Hospital, 1-1 Yazako-Karimata, Nagakute, Aichi, 480-1195, Japan.

Purpose: To examine the clinicopathological characteristics of patients with thyroid eye disease (TED) who showed asymmetric lacrimal gland enlargement.

Methods: Sixteen patients were included in this retrospective, observational case series. The following data were collected: sex, age, laterality, past medical history, laboratory results for thyroid function and other autoimmune disorders, pathological results, other systemic lesions related to lacrimal gland pathology, and the clinical course after treatment. Read More

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November 2018
1 Read

microRNA-29a-3p, Up-Regulated in Human Gastric Cells and Tissues with H.Pylori Infection, Promotes the Migration of GES-1 Cells via A20-Mediated EMT Pathway.

Cell Physiol Biochem 2018 28;51(3):1250-1263. Epub 2018 Nov 28.

School of Medicine, Jiangsu University, Zhenjiang, China.

Background/aims: Helicobacter pylori (H. pylori) infection is closely related to human gastric mucosa-associated diseases. Several recent studies on miRNAs have expanded our insights on H. Read More

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November 2018
3 Reads
2.875 Impact Factor

Roles of Cholesteryl-α-Glucoside Transferase and Cholesteryl Glucosides in Maintenance of Helicobacter pylori Morphology, Cell Wall Integrity, and Resistance to Antibiotics.

MBio 2018 Nov 27;9(6). Epub 2018 Nov 27.

Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad, India

Infection of the human stomach caused by is very common, as the pathogen colonizes more than half of the world's population. It is associated with varied outcomes of infection, such as peptic ulcer disease, gastric ulcers, and mucosa-associated lymphoid tissue lymphoma, and is generally considered a risk factor for the development of gastric adenocarcinoma. Cholesteryl glucosides (CGs) constitute a vital component of the cell wall of and contribute to its pathogenicity and virulence. Read More

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November 2018
1 Read

Multimodality fMRI with perfusion, diffusion-weighted MRI and H-MRS in the diagnosis of lympho-associated benign and malignant lesions of the parotid gland.

J Magn Reson Imaging 2018 Nov 26. Epub 2018 Nov 26.

Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Department of Radiology, Shanghai, P.R. China.

Background: Differential diagnosis of the mucosa-associated lymphoid tissue lymphoma (MALToma) and tumor-like benign lymphoepithelial lesion (BLEL) in the parotid gland is difficult.

Purpose: To distinguish MALToma and BLEL with multimodality MRI including hydrogenproton magnetic resonance spectroscopy ( H-MRS), diffusion-weighted imaging (DWI-MR), and dynamic contrast-enhanced (DCE-MR), and evaluate each sequence.

Study Type: Retrospective. Read More

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November 2018
6 Reads

An Overview of the Pathology and Emerging Treatment Approaches for Interstitial Cystitis/Bladder Pain Syndrome.

Cureus 2018 Sep 17;10(9):e3321. Epub 2018 Sep 17.

Hematology/Oncology, University of Arizona Cancer Center, Tucson, USA.

Our article will discuss bladder pain syndrome (BPS), which is the presence of chronic suprapubic pain to bladder filling accompanied by other urinary symptoms, such as frequency, urgency, discomfort with filling, and relief with emptying of the bladder in the absence of infections or other pathology. It is mostly seen in females and occurs in 0.06%-30% of the population. Read More

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September 2018
2 Reads

Differential clustering of faecal and mucosa-associated microbiota in healthy individuals.

J Dig Dis 2018 Nov 22. Epub 2018 Nov 22.

Department of Microbiology, Tumor and Cell biology & Science for Life Laboratory, Karolinska Institute, Solna, Sweden.

Background: Faecal samples are often used to characterise gut microbiota, since they are easily collected. However, whether or not the faecal microbiota differ from the mucosa-associated microbiota remains largely unknown. This may be specifically relevant in conditions that are characterised by complex mucosal microbe-host interactions, such as Crohn's disease. Read More

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November 2018
4 Reads

Recent progress in follicular lymphoma in Japan and characteristics of the duodenal type.

Pathol Int 2018 Nov 20. Epub 2018 Nov 20.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan.

The incidence of lymphoma has rapidly increased over the last 40 years in Japan, following a trend that is very similar to that of breast cancer. In particular, the relative frequency of follicular lymphoma (FL) has reached that in Western countries. Given its indolence, a "watch-and-wait" approach is often applied to FL patients. Read More

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November 2018
9 Reads

Helicobacter pylori evasion strategies of the host innate and adaptive immune responses to survive and develop gastrointestinal diseases.

Microbiol Res 2019 Jan 6;218:49-57. Epub 2018 Oct 6.

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Electronic address:

Helicobacter pylori (H. pylori) is a bacterial pathogen that resides in more than half of the human population and has co-evolved with humans for more than 58,000 years. This bacterium is orally transmitted during childhood and is a key cause of chronic gastritis, peptic ulcers and two malignant cancers including MALT (mucosa-associated lymphoid tissue) lymphoma and adenocarcinoma. Read More

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January 2019
5 Reads

Key pathway and gene alterations in the gastric mucosa associated with obesity and obesity-related diabetes.

J Cell Biochem 2018 Nov 18. Epub 2018 Nov 18.

Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Background And Objective: The stomach plays an important role in obesity and obesity-related diabetes; yet, little is known about key pathways in the gastric mucosa associated with obesity and diabetes.

Methods: We performed gene microarray and real time-polymerase chain reaction (RT-PCR) on gut mucosa samples from control subjects (CON), patients with simple obesity (OB), and patients with obesity and comorbid diabetes (OD) (n = 3 per group). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were used to predict the functional significance of differentially expressed genes. Read More

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November 2018
3 Reads
3.263 Impact Factor

[Primary Lung Cancer Initially Suspected of Pulmonary Extranodal Marginal Zone Lymphoma of Mucosa Associated Lymphoid Tissue(MALT)].

Kyobu Geka 2018 Nov;71(12):1013-1017

Department of General Thoracic Surgery, Fukuoka Higashi Medical Center, Koga, Japan.

Pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is associated with pre-existing infections or autoimmune disorders. We report a case of lung cancer initially suspected of MALT lymphoma. The patient was a 73-year-old woman. Read More

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November 2018
1 Read

Pleural Mucosa-associated Lymphoid Tissue Lymphoma with Trisomy 18.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Department of Respiratory Medicine, Hikone Municipal Hospital, Japan.

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November 2018
1 Read

IL23R-protective coding variant promotes beneficial bacteria and diversity in the ileal microbiome in healthy individuals without inflammatory bowel disease.

J Crohns Colitis 2018 Nov 16. Epub 2018 Nov 16.

Inflammatory Bowel Diseases, QIMR Berghofer Medical Research Institute, Herston, Brisbane 4006, Australia.

Background And Aims: This study aimed to characterise the mucosa-associated microbiota in ileal Crohn's disease (CD) patients and in healthy controls in terms of host genotype and inflammation status.

Methods: The mucosa-associated microbiota of intestinal pinch biopsies from 15 ileal CD patients with mild and moderate disease and from 58 healthy controls were analysed by 16S ribosomal sequencing to determine microbial profile differences between (1) IL23R, NOD2 and ATG16L1 genotypes in healthy subjects, (2) ileal CD patients and control subjects, and (3) inflamed and non-inflamed mucosal tissue in CD patients.

Results: The protective variant of the IL23R gene (rs11209026) significantly impacted the microbial composition in the ileum of healthy subjects and was associated with an increased abundance of phylotypes within the Christensenellaceae family as well as increases in diversity and richness. Read More

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November 2018
2 Reads

The CD4CD8 MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8 MAIT cell pool.

Proc Natl Acad Sci U S A 2018 Dec 15;115(49):E11513-E11522. Epub 2018 Nov 15.

Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden;

Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells that recognize microbial riboflavin metabolites presented by the MHC class I-like protein MR1. Human MAIT cells predominantly express the CD8α coreceptor (CD8), with a smaller subset lacking both CD4 and CD8 (double-negative, DN). However, it is unclear if these two MAIT cell subpopulations distinguished by CD8α represent functionally distinct subsets. Read More

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December 2018
8 Reads

M cell targeting engineered biomaterials for effective vaccination.

Biomaterials 2018 Nov 12;192:75-94. Epub 2018 Nov 12.

Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 08826, South Korea. Electronic address:

Vaccines are one of the greatest medical interventions of all time and have been successful in controlling and eliminating a myriad of diseases over the past two centuries. Among several vaccination strategies, mucosal vaccines have wide clinical applications and attract considerable interest in research, showing potential as innovative and novel therapeutics. In mucosal vaccination, targeting (microfold) M cells is a frontline prerequisite for inducing effective antigen-specific immunostimulatory effects. Read More

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November 2018
2 Reads

Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma.

Intern Med 2018 15;57(22):3249-3254. Epub 2018 Nov 15.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan.

The number of patients with methotrexate-associated lymphoproliferative disorder (MTX-LPD) is increasing. We describe a case of MTX-LPD of the stomach. After treatment with methotrexate for rheumatoid arthritis, the patient developed left cervical lymphadenopathy and an ulcerative lesion in the stomach, which was presumed to be a mucosa-associated lymphoid tissue (MALT) lymphoma. Read More

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November 2018
1 Read

Comparison of patients with and without pre-existing lymphoma at diagnosis of primary Sjögren's syndrome.

Scand J Rheumatol 2018 Nov 13:1-6. Epub 2018 Nov 13.

a Department of Medical Sciences, Section of Rheumatology , Uppsala University , Uppsala , Sweden.

Objective: In the 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome (pSS), pre-existing lymphoma is not an exclusion criterion for pSS diagnosis, as in earlier criteria. We aimed to explore whether there are differences between pSS patients with and without pre-existing lymphoma at pSS diagnosis.

Method: Patients with ICD-7-10 codes for Sjögren's syndrome (SS) and a diagnosis of malignant lymphoma before or after SS diagnosis were identified by linking the Swedish Patient Register 1964-2007 with the Cancer Register 1990-2007 (n = 224). Read More

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November 2018
2 Reads

Gastroduodenal "Dysbiosis": a New Clinical Entity.

Curr Treat Options Gastroenterol 2018 Dec;16(4):591-604

Department of Gastroenterology and Hepatology, Princess Alexandra Hospital Brisbane, 199 Ipswich Road, Woolloongabba, QLD, 4102, Australia.

Purpose Of Review: Like the rest of the gastrointestinal tract, the small intestine is colonised by microbes, but how this "microbiome" affects the immune system and digestive functions has largely been overlooked, especially in the "omics" era. Here, we present recent findings that show that the diversity, density and interactions of these microbes in the small intestine can play an important role in the pathogenesis of a number of gastrointestinal and extraintestinal disorders.

Recent Findings: Changes in the small intestinal mucosa-associated microbiota (SI-MAM) have been shown to occur with inflammatory bowel diseases, functional gastrointestinal disorders, metabolic disorders such as obesity and type 2 diabetes. Read More

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December 2018
2 Reads

Accelerated onset of chronic wasting disease in elk (Cervus canadensis) vaccinated with a PrP-specific vaccine and housed in a prion contaminated environment.

Vaccine 2018 Nov 7;36(50):7737-7743. Epub 2018 Nov 7.

Vaccine and Infectious Disease Organization-International Vaccine Research Center, University of Saskatchewan, 120 Veterinary Road, S7N 5E3 Saskatoon, Saskatchewan, Canada; Department of Biochemistry, University of Saskatchewan, 107 Wiggins Road, S7N 5E5 Saskatoon, Saskatchewan, Canada.

Chronic wasting disease (CWD) is a fatal prion disease affecting multiple cervid species. Effective management tools for this disease, particularly in free-ranging populations, are currently limited. We evaluated a novel CWD vaccine in elk (Cervus canadensis) naturally exposed to CWD through a prion-contaminated environment. Read More

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November 2018
6 Reads

Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal cancers: exploring a common ground hypothesis.

J Biomed Sci 2018 Nov 9;25(1):79. Epub 2018 Nov 9.

Graduate Institute of Physiology, National Taiwan University College of Medicine, Suite 1020, #1 Jen-Ai Rd. Sec. 1, Taipei, 100, Taiwan, Republic of China.

Inflammatory bowel disease (IBD) is a multifactorial disease which arises as a result of the interaction of genetic, environmental, barrier and microbial factors leading to chronic inflammation in the intestine. Patients with IBD had a higher risk of developing colorectal carcinoma (CRC), of which the subset was classified as colitis-associated cancers. Genetic polymorphism of innate immune receptors had long been considered a major risk factor for IBD, and the mutations were also recently observed in CRC. Read More

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November 2018
8 Reads

Primary Tracheal Mucosa-Associated Lymphoid Tissue Lymphoma Treated with a Water-Jet Hybrid Knife: A Case Report.

Respiration 2018 Nov 8:1-5. Epub 2018 Nov 8.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing,

Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the trachea is very rare and is easily misdiagnosed as a bronchogenic carcinoma or benign tracheal tumor. Here, we report a clinical case where a new clinical approach involving a water-jet hybrid knife was employed in the diagnosis and treatment of primary tracheal MALT lymphoma. Read More

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November 2018
3 Reads

An RORγt Oral Inhibitor Modulates IL-17 Responses in Peripheral Blood and Intestinal Mucosa of Crohn's Disease Patients.

Front Immunol 2018 22;9:2307. Epub 2018 Oct 22.

Department of Gastroenterology, IDIBAPS, Hospital Clínic, CIBERehd, Barcelona, Spain.

Despite the negative results of blocking IL-17 in Crohn's disease (CD) patients, selective modulation of Th17-dependent responses warrants further study. Inhibition of retinoic acid-related orphan receptor gamma (RORγt), the master regulator of the Th17 signature, is currently being explored in inflammatory diseases. Our aim was to determine the effect of a novel oral RORγt antagonist (BI119) in human CD and on an experimental model of intestinal inflammation. Read More

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October 2018
3 Reads

Human retinoic acid-regulated CD161 regulatory T cells support wound repair in intestinal mucosa.

Nat Immunol 2018 Dec 5;19(12):1403-1414. Epub 2018 Nov 5.

MRC, Centre for Transplantation, King's College London, London, UK.

Repair of tissue damaged during inflammatory processes is key to the return of local homeostasis and restoration of epithelial integrity. Here we describe CD161 regulatory T (T) cells as a distinct, highly suppressive population of T cells that mediate wound healing. These T cells were enriched in intestinal lamina propria, particularly in Crohn's disease. Read More

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December 2018
17 Reads

Diagnostic and Therapeutic Implications of Pulmonary Lymphoma Associated with Nodular Amyloidosis.

Ann Thorac Surg 2018 Nov 2. Epub 2018 Nov 2.

Department of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.

Pulmonary localization of B-cell lymphoma associated with deposits of amyloid material is a rare finding among the thoracic diseases spectrum. We report a rare case of nodular pulmonary amyloidosis in a 50-year-old patient. He underwent to a left upper lobectomy due to a Mucosa Associated Lymphoid Tissue (MALT) lymphoma which originated from the bronchial lymphoid tissue. Read More

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November 2018
1 Read

[Extra-ganglionar non-Hodgkin mucosa-associated lymphoid tissue lymphoma presenting as acute appendicitis in a nonagenarian patient].

Rev Esp Geriatr Gerontol 2018 Oct 31. Epub 2018 Oct 31.

Servicio de Geriatría y Cuidados Paliativos, Hospital Moisès Broggi Sant Joan Despì-Consorci Sanitari Integral, Sant Joan Despí, Barcelona, España.

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October 2018
1 Read

Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes.

Sci Rep 2018 Oct 30;8(1):15998. Epub 2018 Oct 30.

Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370, Wroclaw, Poland.

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) belongs to the CD clan of cysteine proteases. MALT1 is a unique enzyme among this clan because it recognizes the basic amino acid arginine in the P1 pocket. Previous studies carried out with natural amino acids revealed the substrate specificity of the P4-P1 pockets of MALT1 but have provided only limited information about the catalytic preferences of this enzyme. Read More

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October 2018
3 Reads

Efficacy of compound tablets combined with quadruple therapy for eradication and its correlation with pH value in the stomach: a study protocol of a randomised, assessor-blinded, single-centre study.

BMJ Open 2018 Oct 28;8(10):e023131. Epub 2018 Oct 28.

Department of Gastroenterology, Chongqing University Cancer Hospital &Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, China.

Introduction: (Hp) is an important pathogenic factor for chronic gastritis, peptic ulcer, gastric cancer, gastric mucosa-associated lymphoid tissue lymphoma and other diseases. In China, the Hp infection rate is high, but the eradication rate is decreasing. A large number of literatures have shown that the addition of can improve the Hp eradication rate and reduce the side effects of antibiotic treatments. Read More

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October 2018
5 Reads

Bacterial imbalance and gut pathologies: Association and contribution of E. coli in inflammatory bowel disease.

Crit Rev Clin Lab Sci 2018 Oct 29:1-17. Epub 2018 Oct 29.

i Phase I-Early Clinical Trials Unit, Oncology Department and Multidisciplinary Oncology Center Antwerp (MOCA) , Antwerp University Hospital , Edegem , Belgium.

Hosts and microbes have co-evolved over millions of years. Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-mediated diseases. Although the etiology of IBD remains an enigma, various studies have proposed the involvement of mucosa-associated Escherichia coli (E. Read More

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October 2018
3 Reads

Tissue-resident MAIT cell populations in human oral mucosa exhibit an activated profile and produce IL-17.

Eur J Immunol 2018 Oct 29. Epub 2018 Oct 29.

Center for Infection Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Mucosa-associated invariant T (MAIT) cells are unconventional T lymphocytes defined by their innate-like characteristics and broad antimicrobial responsiveness. Whether MAIT cells are part of the tissue-resident defense in the oral mucosal barrier is unknown. Here, we found MAIT cells present in the buccal mucosa, with a tendency to cluster near the basement membrane, and located in both epithelium and the underlying connective tissue. Read More

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October 2018
12 Reads

The Effect of Rebamipide Ophthalmic Solution on Cytokine and Mucin Secretion in Culture of Conjunctival Epithelial Cells From the Cu, Zn-Superoxide Dismutase-1 (SOD-1) Knock-Down Mouse.

Eye Contact Lens 2018 Oct 25. Epub 2018 Oct 25.

Department of Ophthalmology (M.O., A.I., M.D., J.S.), Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan; and Department of Ophthalmology (C.S., T.K., T.N., T.K., M.D., K.T.), Keio University School of Medicine, Tokyo, Japan.

Objectives: To evaluate the in vitro effects of 1-mM rebamipide ophthalmic solution on the expression of inflammatory cytokines and MUC5AC in Cu, Zn-superoxide dismutase-1 (SOD-1) knock-down conjunctival epithelium.

Methods: Conjunctival epithelium from C57BL/6 wild-type mice was cultured and treated with rebamipide ophthalmic solution. Using cytometric bead array, we examined the levels of interleukin-(IL)-6, IL-10, IL-17, monocyte chemoattractant protein-1, interferon-γ (INF-γ), tumor necrosis factor, and IL-12p70 in the culture supernatants. Read More

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October 2018
5 Reads

MALT lymphoma: epidemiology, clinical diagnosis and treatment.

J Med Life 2018 Jul-Sep;11(3):187-193

"Carol Davila" University of Medicine and Pharmacy, Bucharest.

Primary gastric lymphoma (PGL) represents a rare pathology, which can be easily misdiagnosed because of unspecific symptoms of the digestive tract. Histologically, PGL can vary from indolent marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) to aggressive diffuse large B-cell lymphoma (DLBCL). During the years, clinical trials revealed the important role of Helicobacter pylori (H. Read More

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December 2018
5 Reads

Impact of high-grain diet feeding on mucosa-associated bacterial community and gene expression of tight junction proteins in the small intestine of goats.

Microbiologyopen 2018 Oct 24:e745. Epub 2018 Oct 24.

Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, Laboratory of Gastrointestinal Microbiology, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu Province, China.

The objective of this study was to investigate the impact of a high-grain (HG) diet on the microbial fermentation, the composition of the mucosa-associated bacterial microbiota, and the gene expression of tight junction proteins in the small intestine of goats. In the present study, we randomly assigned 10 male goats to either a hay diet (n = 5) or a HG diet (56.5% grain; n = 5) and then examined changes in the bacterial community using Illumina MiSeq sequencing and the expression of tight junction proteins using qRT-PCR in the mucosa of the small intestine. Read More

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October 2018
9 Reads

Clinicopathological characteristics and prognostic factors for primary thyroid lymphoma: report on 28 Chinese patients and results of a population-based study.

Cancer Manag Res 2018 10;10:4411-4419. Epub 2018 Oct 10.

Department of Head and Neck Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China,

Objectives: Few studies on prognostic indicators for primary thyroid lymphoma (PTL) have been presented due to the uncommon nature of the tumor. This is the first study to explore the independent prognostic factors in the 2 PTL subtypes.

Methods: We retrospectively reviewed 1,653 cases of PTL. Read More

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October 2018
3 Reads

Case presentation: persistent adenovirus B3 infections associated with bronchiolitis obliterans treated with cidofovir in a child with mosaic tetrasomy 9p.

BMC Infect Dis 2018 Oct 22;18(1):529. Epub 2018 Oct 22.

Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.

Background: Adenoviruses (AdV) are non-enveloped, double-stranded DNA viruses with multiple serotypes, which cause a variety of end-organ disease in both immunocompetent and immunocompromised individuals. Some adenoviruses can become latent in the mucosa-associated lymphoid tissue (e.g. Read More

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October 2018
2 Reads

Diagnosis of Infection in Children and Adolescents in Korea.

Pediatr Gastroenterol Hepatol Nutr 2018 Oct 10;21(4):219-233. Epub 2018 Oct 10.

Department of Pediatrics, Gyeongsang National Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju, Korea.

plays an important role in the pathogenesis of chronic gastritis, peptic ulcer disease, gastric cancer, and gastric mucosa-associated lymphoid tissue lymphoma. In Korea, the guidelines for the diagnosis and treatment of infection in adults were revised in 2013. The European Helicobacter and Microbiota Study Group and Consensus panel released the fifth edition of the Maastricht Consensus Report for the management of infection in 2015, and the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the North American Society of Paediatric Gastroenterology, Hepatology and Nutrition released the updated joint guidelines for children and adolescents in 2016. Read More

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October 2018
1 Read

An Optimized Protocol for the Isolation and Functional Analysis of Human Lung Mast Cells.

Front Immunol 2018 5;9:2193. Epub 2018 Oct 5.

Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Mast cells are tissue-resident inflammatory cells defined by their high granularity and surface expression of the high-affinity IgE receptor, FcεRI, and CD117/KIT, the receptor for stem cell factor (SCF). There is a considerable heterogeneity among mast cells, both phenotypically and functionally. Human mast cells are generally divided into two main subtypes based on their protease content; the mucosa-associated MC (tryptase positive and chymase negative mast cell) and the connective tissue associated-residing MC (tryptase and chymase positive mast cell). Read More

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October 2018
14 Reads

Yogurt starter cultures of Streptococcus thermophilus and Lactobacillus bulgaricus ameliorate symptoms and modulate the immune response in mouse model of dextran sulfate sodium-induced colitis.

J Dairy Sci 2018 Oct 18. Epub 2018 Oct 18.

Department of Immunology and Food Microbiology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10-748 Olsztyn, Poland.

We investigated the yogurt starter cultures of Lactobacillus bulgaricus 151 and Streptococcus thermophilus MK-10 for their effect on the severity of experimental colitis, lymphocyte profile, and regulatory T cell response. Colitis was induced in BALB/c mice via the administration of 3.5% dextran sulfate sodium salt (DSS) in drinking water for 6 d. Read More

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October 2018

Cell surface polysaccharides of induce the generation of Foxp3 regulatory T cells.

Sci Immunol 2018 Oct;3(28)

Academy of Immunology and Microbiology, Institute for Basic Science, Pohang 37673, Republic of Korea.

Dysregulation of intestinal microflora is linked to inflammatory disorders associated with compromised immunosuppressive functions of Foxp3 T regulatory (T) cells. Although mucosa-associated commensal microbiota has been implicated in T generation, molecular identities of the "effector" components controlling this process remain largely unknown. Here, we have defined as a potent inducer of Foxp3 T cells with diverse T cell receptor specificity to dietary antigens, commensal bacteria, and itself. Read More

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October 2018
12 Reads

[Results of a retrospective study on radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma].

Cancer Radiother 2018 Dec 15;22(8):763-766. Epub 2018 Oct 15.

Service de radiothérapie carcinologique, CHU Habib-Bourguiba, avenue Majida-Boulila, 3027 Sfax, Tunisie.

Purpose: We aimed to evaluate therapeutic results of radiotherapy for gastric mucosa-associated lymphoid tissue (MALT) lymphomas.

Patients And Methods: We reviewed retrospectively the records of 11 patients presenting with gastric MALT lymphoma treated between 1993 and 2014. Patients with low-grade lymphoma in failure after helicobacter eradication had exclusive gastric external radiotherapy. Read More

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December 2018
7 Reads

MALT1 activation by TRAF6 needs neither BCL10 nor CARD11.

Biochem Biophys Res Commun 2018 Nov 15;506(1):48-52. Epub 2018 Oct 15.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland. Electronic address:

The MALT1 (Mucosa associated lymphoid tissue lymphoma translocation protein 1) paracaspase couples antigen receptors on lymphocytes to downstream signaling events. Activation of MALT1 is known to involve stimulus-dependent CBM complex formation, that is, the recruitment of BCL10-bound MALT1 to a CARD-Coiled Coil protein. Beyond this canonical, CBM-dependent mechanism of MALT1 activation, recent studies suggest that MALT1 protease activity may be triggered by alternative mechanisms. Read More

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November 2018
4 Reads

[Clinicopathologic features of breast lymphoma in core needle biopsy].

Zhonghua Bing Li Xue Za Zhi 2018 Oct;47(10):737-742

Department of Pathology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

To investigate the clinicopathologic features and differential diagnosis of breast lymphoma in core needle biopsy. Seventy-two cases of breast lymphoma in core needle biopsy between 2011 and 2016 were extracted from the pathology database of Fudan University Shanghai Cancer Center. The clinicopathologic features were analyzed. Read More

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October 2018
9 Reads

Primary mucosa-associated lymphoid tissue lymphoma of the hilar bile duct resulting in fluctuant jaundice: A case report.

Medicine (Baltimore) 2018 Oct;97(41):e12830

General Surgery Center.

Rationale: Primary mucosa-associated lymphoid tissue (MALT) lymphomas rarely originate in the hilar bile duct. Preoperative diagnosis of a primary MALT lymphoma of the hilar bile duct is difficult owing to the rarity of this disease. Differentiating between obstructive jaundice caused by MALT lymphoma of the hilar bile duct and hilar cholangiocarcinoma (the most common form of bile duct cancer) is challenging. Read More

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October 2018
2 Reads

Risk Factors for Transformation to Higher-Grade Lymphoma and Its Impact on Survival in a Large Cohort of Patients With Marginal Zone Lymphoma From a Single Institution.

J Clin Oncol 2018 Oct 12:JCO1800138. Epub 2018 Oct 12.

All authors: Sylvester Comprehensive Cancer Center, Miami, FL.

Purpose: Given the paucity of data on higher-grade transformation (HGT) to aggressive lymphoma in patients with marginal zone lymphoma (MZL), we report on a large cohort of patients, identify risk factors, and determine HGT impact on overall survival (OS).

Methods: We analyzed 453 patients with biopsy-proven MZL seen at our institution between 1995 and 2016. Kaplan-Meier, Cox proportional hazards regression, and competing risk methods were used in analyses of time-to-event outcomes. Read More

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October 2018
5 Reads

Validation of the Marginal Zone Lymphoma International Prognostic Index.

Ann Hematol 2018 Oct 11. Epub 2018 Oct 11.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, School of Medicine, Sungkyunkwan Universitye, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

The Marginal Zone Lymphoma International Prognostic Index (MALT-IPI) was recently developed for use in patients with mucosa-associated lymphoid tissue (MALT) lymphoma based on age, serum lactate dehydrogenase level, and Ann Arbor stage. In this study, we aimed to validate the MALT-IPI. A total of 455 MALT lymphoma patients were included in this study from between January 2005 and February 2017. Read More

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October 2018
10 Reads

Colostrum feeding shapes the hindgut microbiota of dairy calves during the first 12 h of life.

FEMS Microbiol Ecol 2019 Jan;95(1)

Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G2P5, Canada.

This study evaluated the effect of feeding non-heated and heated colostrum on the mucosa- and digesta-associated microbiota in the colon of dairy calves during the first 12 h of life. Thirty-two neonatal Holstein male calves were fed: no colostrum (NC, n = 8), non-heated colostrum (FC, n = 12) and heated colostrum (HC (60 °C, 60 min), n = 12) immediately after birth. The abundances of mucosa- and digesta-associated total bacteria were higher in the colon of FC fed calves compared to those fed no colostrum (NC) at 12 h of life. Read More

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January 2019
1 Read

IgG4 expression in cutaneous marginal zone lymphoma with plasmacytic differentiation and localized amyloid deposition: A useful clue to cutaneous origin.

JAAD Case Rep 2018 Oct 3;4(9):883-886. Epub 2018 Oct 3.

Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York.

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October 2018
3 Reads