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QJM 2021 Jun 14. Epub 2021 Jun 14.

Yong Loo Lin School of Medicine, National University of Singapore and Division of Neurology, National University Hospital, Singapore.

Covid-19 pandemic is in a massive second wave in India. The new variant is considered more infectious. Diabetic patients are considered more vulnerable to develop some of the complications of acute Covid-19 infections. Read More

J Infect 2021 Jun 11. Epub 2021 Jun 11.

Dept of LifeSciences, Gujarat University, Ahmedabad, Gujarat, INDIA. Electronic address:

Front Med (Lausanne) 2021 28;8:645270. Epub 2021 May 28.

Department of Radiology, Ain Shams University Hospitals, Cairo, Egypt.

To determine if there was an increase in the rate of cases presenting with rhino-orbital-cerebral mucormycosis (ROCM) to a tertiary care center during the first wave of the coronavirus disease 2019 (COVID-19) pandemic and the characteristics of the presenting cases. Retrospective observational study reviewing ROCM cases presenting from March 25 until September 25, 2020. Cases fulfilling the clinical, radiological, and pathological/microbiological criteria for diagnosis with ROCM were included. Read More

Eur J Case Rep Intern Med 2021 5;8(5):002435. Epub 2021 May 5.

Department of Critical Care Medicine at King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Mucormycosis is a rare fungal infection that often causes rhinocerebral disease. However, there have been rare cases of mediastinal involvement. These patients remain a therapeutic challenge and mortality in this group is very high. Read More

J Wound Care 2021 Jun;30(6):465-468

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

This case report describes the progressive wound infection in the left thigh of a 34-year-old man due to an old landmine explosion. The infection developed into rapidly spreading skin and soft tissue necrotising infection, despite antifungal therapy and surgical debridement. The report provides evidence that spp. Read More

Trop Med Int Health 2021 Jun 11. Epub 2021 Jun 11.

School of Medicine, Centro Escolar University, Manila, Philippines.

In addition to the overwhelming and uncontrollable second wave of COVID-19 in India, the country is also dealing with an outbreak of mucormycosis, a deadly fungal infection, which is affecting thousands of COVID-19 patients. With the increasing number of cases of mucormycosis and a fatality rate of 50%, many Indian states and union territories have declared an epidemic of black fungus due to its unprecedented emergence which has adversely affected the already debilitated health system of the country. The advent of the new fungal epidemic in the country is due to the overdosage, panic, and injudicious use of corticosteroids among COVID-19 patients, as well as their pre-existing medical history of diabetes, given that India is the diabetes capital of the world. Read More

Euro Surveill 2021 06;26(23)

Center for Infectious Disease Research, Diagnostics and Laboratory Surveillance National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

We describe four secondary fungal infections caused by Mucorales species in COVID-19 patients. Three COVID-19 associated mucormycosis (CAM) occurred in ICU, one outside ICU. All were men aged > 50 years, three died. Read More

Immunotherapy 2021 Jun 11. Epub 2021 Jun 11.

Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan.

QJM 2021 Jun 9. Epub 2021 Jun 9.

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

Trop Doct 2021 Jun 9:494755211010007. Epub 2021 Jun 9.

Professor, Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Postgrad Med J 2021 Jun 8. Epub 2021 Jun 8.

Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Ann Intern Med 2021 Jun 8. Epub 2021 Jun 8.

University of Massachusetts Medical School, Worcester, Massachusetts (S.R., S.M.L.).

Mycoses 2021 Jun 7. Epub 2021 Jun 7.

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: The aim of the study was to report clinical features, contributing factors and outcome of patients with coronavirus disease 2019 (COVID-19) associated mucormycosis (CAM).

Methods: A cross-sectional descriptive multicenter study was conducted on patients with biopsy-proven mucormycosis with RT-PCR confirmed COVID-19 from April to September 2020. Demographics, the time interval between COVID-19 and mucormycosis, underlying systemic diseases, clinical features, course of disease and outcomes were collected and analyzed. Read More

Am J Ophthalmol Case Rep 2021 Jun 16;22:101092. Epub 2021 Apr 16.

Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Purpose: Rhino-orbital-cerebral mucormycosis (ROCM) is a rare opportunistic infection with a high mortality despite relevant treatment.

Observations: A 3-year-old girl under treatment for acute lymphoblastic leukemia developed periorbital swelling, ophthalmoplegia and a necrotic palatal lesion during a period of neutropenia. Imaging revealed sinusitis, pre- and postseptal cellulitis. Read More

Lancet Respir Med 2021 Jun 3. Epub 2021 Jun 3.

School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.

Med Hypotheses 2021 Jul 26;152:110613. Epub 2021 May 26.

Department of Oral Pathology and Microbiology, Government Dental College, Kozhikode, Kerala, India.

Corona Virus Disease 2019 (COVID 2019), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a dreadful infectious disease which has emerged as one of the most significant medical emergency affecting everyone directly or indirectly. COVID 2019 is a multisystem disease and causes severe immunosuppression. Initially thought to affect mainly the respiratory system, it strikes all vital organ systems and cause defects in cardio-circulatory, respiratory system and gastrointestinal systems to name a few leading to copious biochemical alterations. Read More

J Neuroradiol 2021 Jun 1. Epub 2021 Jun 1.

Ain Shams University, Faculty of Medicine, Department of Otolaryngology, Cairo, Egypt. Electronic address:

Background: The incidence of devastating opportunistic coinfections in patients with COVID-19 infection, their imaging features and their morbidity and mortality consequences need to be unraveled.

Methods: This is a case series presenting the radiologic features and clinical presentation of acute invasive fungal rhino-orbital-cerebral sinusitis (AIFS) in eight hospitalized patients with confirmed COVID-19 infection.

Results: Our patient cohort presented with symptoms of the invasive fungal disease within 12-35 days from their initial presentation with COVID-19 infection. Read More

Emerg Infect Dis 2021 Jun 4;27(9). Epub 2021 Jun 4.

During September-December 2020, we conducted a multicenter retrospective study across India to compare epidemiology and outcomes among cases of coronavirus disease (COVID-19)-associated mucormycosis (CAM). Among 287 mucormycosis patients, 187 (65.2%) had CAM; CAM prevalence was 0. Read More

Expert Opin Ther Pat 2021 Jun 3. Epub 2021 Jun 3.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha, Saudi Arabia.

Introduction: Mucormycosis is an uncommon but life-threatening infection with non-specific clinical manifestations that make its diagnosis/treatment difficult. The current literature indicates that mucormycosis case incidences are on the rise in developing and developed countries, and, unfortunately, there are only a few treatments available. Accordingly, it is essential to provide more treatment options for mucormycosis. Read More

Transpl Infect Dis 2021 Jun 3:e13663. Epub 2021 Jun 3.

Department of Nephrology and Transplantation, IKDRC-ITS, Ahmedabad, India.

Eur Arch Otorhinolaryngol 2021 Jun 1. Epub 2021 Jun 1.

Department of Otorhinolaryngology, University of Mersin School of Medicine, Çiftlikköy Kampüsü, Çiftlikköy/Yenişehir, Mersin, Turkey.

Purpose: To investigate the factors affecting disease specific mortality (DSM) in patients with mucormycosis.

Methods: This retrospective study included 24 patients diagnosed with mucormycosis and who had undergone surgical and medical treatment between 2010 and 2020. There were 14 male and 10 female patients whose mean age was 53. Read More

IDCases 2021 28;25:e01172. Epub 2021 May 28.

Department of Respiratory Medicine, Royal Brompton and Harefield Hospital, Guy's and St.Thomas Hospital NHS Foundation Trust, London, United Kingdom.

Among the secondary fungal infections in Coronavirus-19 (COVID-19) infection, Aspergillosis has been reported more often than Mucormycosis. Disseminated mucormycosis is almost always a disease of severely immunosuppressed hosts. We report a young obese Asian male who was admitted with an acute anterior cerebral artery (ACA) territory infarct and severe COVID-19 pneumonitis to the intensive care unit (ICU). Read More

Int J Surg Case Rep 2021 May 25;83:106010. Epub 2021 May 25.

Division of Trauma, Department of General Surgery, Charlotte Maxeke Johannesburg Academic Hospital, 5 Jubilee Street, Parktown, Johannesburg, South Africa.

Introduction And Importance: Gastric mucormycosis is a rare condition that usually manifests in immunocompromised patients. It's a lethal disease with a poor prognosis requiring prompt diagnosis and aggressive management. Although found more commonly in immunocompromised patients, it can also affect the immunocompetent patient, highlighting the importance of clinical suspicion when dealing with a critically ill patient. Read More

Jpn J Ophthalmol 2021 May 31. Epub 2021 May 31.

Department of Otorhinolaryngology-Head and Neck Surgery, Kayseri City Training and Research Hospital, University of Health Science, Kayseri, Turkey.

Purpose: To present the different clinical manifestations of rhino-orbital mucormycosis (ROM) co-infection in severe COVID-19 patients.

Study Design: Prospective observational clinical study METHODS: Among 32,814 patients hospitalized with the diagnosis of COVID-19 between March 2020 and December 2020 in our center, eleven microbiologically confirmed ROM co-infection cases in severe COVID-19 patients were evaluated.

Results: There were nine men and two women with a mean age of 73. Read More

Indian J Med Microbiol 2021 May 26. Epub 2021 May 26.

Department of Medicine, SP Medical College, Bikaner, Rajasthan, India.

Coronavirus disease 2019 (COVID-19), may present with a myriad of clinical manifestations and complications. Patients with COVID-19 are at increased risk of pulmonary thromboembolism, acute cardiac injury, arrhythmias, acute stroke, and secondary infections. Mucormycosis is a catastrophic fungal infection characterized by vascular invasion, thrombosis, and necrosis of tissues. Read More

Case Rep Med 2021 10;2021:9962624. Epub 2021 May 10.

Ronald Reagan UCLA Medical Center, David Geffen School of Medicine, Kidney Transplant Program, Los Angeles, CA, USA.

Hyperphosphatemia may arise from various conditions including exogenous ingestion, extracellular shifts due to cell death or alterations in acid-base status, increased bone resorption, hormonal dysregulations leading to reduced renal excretion, reduced kidney function, or faulty measurement techniques. We herein present a case of a young pregnant woman who presented with mild acute kidney injury (AKI), invasive mucormycosis receiving liposomal amphotericin, and hyperphosphatemia out of proportion to the degree of kidney injury. While the patient was given routine phosphate-binding agent by her primary care team for presumed AKI-associated hyperphosphatemia, a full investigation by the renal consulting team for contributing factors other than kidney injury revealed that she actually had pseudohyperphosphatemia associated with the use of liposomal amphotericin. Read More

J Med Microbiol 2021 May;70(5)

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

Invasive mucormycosis (IM) is a life-threatening infection caused by fungi belonging to the order Mucorales. Histopathology, culture and radiology are the mainstay of diagnosis but lack sensitivity, leading to a delay in timely diagnosis and intervention. Recently, PCR-based approaches have been shown to be a promising method in diagnosing IM. Read More

Transpl Infect Dis 2021 May 26:e13652. Epub 2021 May 26.

Department of Nephrology and Renal Transplantation, Hospital Clinic de Barcelona, Barcelona, Spain.

Coronavirus disease 2019 (COVID-19) predisposes patients to bacterial and fungal superinfections due to the impairment of the immunological system. Among the associated opportunistic fungal infections, mucormycosis is one of the least frequent but with the highest mortality. We describe two cases of mucormycosis in two kidney transplant recipients, while they were hospitalized for SARS-CoV-2 pneumonia, with rhinosinusal and musculoskeletal involvement, respectively. Read More

Discoveries (Craiova) 2021 Mar 31;9(1):e126. Epub 2021 Mar 31.

Division of Clinical and Translational Research, Larkin Health System, South Miami, FL, USA.

Severe COVID-19 disease is associated with an increase in pro-inflammatory markers, such as IL-1, IL-6, and tumor necrosis alpha, less CD4 interferon-gamma expression, and fewer CD4 and CD8 cells, which increase the susceptibility to bacterial and fungal infections. One such opportunistic fungal infection is mucormycosis. Initially, it was debated whether a person taking immunosuppressants, such as corticosteroids, and monoclonal antibodies will be at higher risk for COVID-19 or whether the immunosuppresive state would cause a more severe COVID-19 disease. Read More

IDCases 2021 11;24:e01132. Epub 2021 May 11.

Bend Dermatology Clinic, Bend, OR, United States.