4,375 results match your criteria Mucormycosis


Development and validation of the European QUALity (EQUAL) score for mucormycosis management in haematology.

J Antimicrob Chemother 2019 Feb 15. Epub 2019 Feb 15.

Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne, Cologne, Germany.

Background: Mucormycosis is a life-threatening infection in immunocompromised patients and in haematological malignancy patients in particular.

Objectives: Our aim was to develop and evaluate a scoring tool to measure adherence to current guidelines for mucormycosis.

Methods: Current guidelines of scientific societies on mucormycosis management were reviewed. Read More

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http://dx.doi.org/10.1093/jac/dkz051DOI Listing
February 2019

Epidemiology and clinical outcomes of invasive mould infections in Indian intensive care units (FISF study).

J Crit Care 2019 Feb 5;51:64-70. Epub 2019 Feb 5.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background And Aim: Due to limited data on invasive mould infections (IMIs) in the intensive care units (ICUs) of developing countries, we ascertain epidemiology and management of IMIs at 11 ICUs across India.

Methods: Consecutive patients with proven or probable/putative IMIs were enrolled during the study period. Subjects were categorized into classical (neutropenia, malignancy, transplant recipients on immunosuppression) and non-classical (chronic obstructive pulmonary disease, diabetes, liver disease and glucocorticoids) risk groups. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.005DOI Listing
February 2019

Pulmonary Mucormycosis in a Patient With Uncontrolled Diabetes.

Fed Pract 2018 Jan;35(1):32-36

and are Internal Medicine Residents at Scott and White Memorial Hospital. and are Physicians at the Central Texas Veterans Health Care System; all in Temple, Texas.

Prompt diagnosis of a patient presenting with rhinocerebral, pulmonary, gastrointestinal, and central nervous system manifestations is critical for treatment of this potentially fatal fungal infection. Read More

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January 2018
1 Read

Invasive sino-orbital fungal infections in immunocompetent patients: a clinico-pathological study.

Eye (Lond) 2019 Feb 14. Epub 2019 Feb 14.

Department of Orbit, Oculoplasty & Ocular Oncology, Aravind Eye Hospital, Madurai, India.

Objective: Invasive sino-orbital fungal infections in immunocompetent patients are a rare clinical entity; the diagnosis and management of which is challenging. We present a large case series of invasive sino-orbital fungal granulomas in patients without pre-existing systemic immunocomprimising condition.

Design: Retrospective case series. Read More

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http://dx.doi.org/10.1038/s41433-019-0358-6DOI Listing
February 2019

An Unusual Case of Large-Vessel Vasculitis.

Eur J Case Rep Intern Med 2018 26;5(7):000897. Epub 2018 Jul 26.

Department of Medicine (Rheumatology), Hamad Medical Corporation, Doha, Qatar.

We report the case of a previously healthy 35-year-old man who presented with severe abdominal pain, nausea, vomiting and subjective fever and was found to have acute kidney injury, haematuria, leukocytosis and elevated inflammatory markers. An abdominal CT scan showed lobar nephronia of the left kidney complicated by infarction. Subsequent MRI also revealed splenic infarction. Read More

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http://dx.doi.org/10.12890/2018_000897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346781PMC

Pulmonary Mucormycosis (Zygomycosis) Presenting as an Infective Exacerbation of Chronic Obstructive Pulmonary Disease.

Eur J Case Rep Intern Med 2018 27;5(12):000995. Epub 2018 Dec 27.

Department of Respiratory Medicine, Nicosia General Hospital, Cyprus.

Mucormycosis is a life-threatening fungal infection whose incidence has been rising recently, mainly due to the increasing use of immunosuppressive and corticosteroid treatment. In previous decades, mucormycosis was associated with a very poor prognosis as mortality was approximately 100%. Mortality rates reported in recent literature have only slightly improved despite the availability of targeted therapy with amphotericin B. Read More

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http://dx.doi.org/10.12890/2018_000995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346968PMC
December 2018
1 Read

Cost-effectiveness analysis of isavuconazole versus voriconazole for the treatment of patients with possible invasive aspergillosis in Sweden.

BMC Infect Dis 2019 Feb 11;19(1):134. Epub 2019 Feb 11.

Department of Medical Sciences, Infectious Diseases, Uppsala University, Uppsala, Sweden.

Background: Voriconazole is well established as standard treatment for invasive aspergillosis (IA). In 2017, isavuconazole, a new antifungal from the azole class, with a broader pathogen spectrum, was introduced in Sweden. A model has therefore been developed to compare the cost-effectiveness of isavuconazole and voriconazole in the treatment of possible IA in adults in Sweden. Read More

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http://dx.doi.org/10.1186/s12879-019-3683-2DOI Listing
February 2019

Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides.

PLoS Genet 2019 Feb 11;15(2):e1007957. Epub 2019 Feb 11.

Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, North Carolina, United States of America.

Mucormycosis-an emergent, deadly fungal infection-is difficult to treat, in part because the causative species demonstrate broad clinical antifungal resistance. However, the mechanisms underlying drug resistance in these infections remain poorly understood. Our previous work demonstrated that one major agent of mucormycosis, Mucor circinelloides, can develop resistance to the antifungal agents FK506 and rapamycin through a novel, transient RNA interference-dependent mechanism known as epimutation. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007957DOI Listing
February 2019

[Acute myeloid leukemia with sudden onset bilateral lower extremity paralysis caused by disseminated mucormycosis following unrelated bone marrow transplantation].

Rinsho Ketsueki 2019 ;60(1):17-21

Division of Hematology, Ehime Prefectural Central Hospital.

A 63-year-old woman was admitted to our hospital with relapsed acute myeloid leukemia. On day10 after reinduction therapy, she became febrile. Computed tomography on day15 revealed right upper lobe consolidation. Read More

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http://dx.doi.org/10.11406/rinketsu.60.17DOI Listing
January 2019
1 Read

Thrives inside the Phagosome through an Atf-Mediated Germination Pathway.

MBio 2019 Feb 5;10(1). Epub 2019 Feb 5.

Departamento de Genética y Microbiología, Universidad de Murcia, Murcia, Spain

Mucormycosis is an emerging fungal infection that is often lethal due to the ineffectiveness of current therapies. Here, we have studied the first stage of this infection-the germination of spores inside phagocytic cells-from an integrated transcriptomic and functional perspective. A relevant fungal gene network is remodeled in response to phagocytosis, being enriched in crucial functions to survive and germinate inside the phagosome, such as nutritional adaptation and response to oxidative stress. Read More

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http://mbio.asm.org/lookup/doi/10.1128/mBio.02765-18
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http://dx.doi.org/10.1128/mBio.02765-18DOI Listing
February 2019
2 Reads

Rhino-orbital Mucormycosis.

Bull Emerg Trauma 2019 Jan;7(1):88-89

Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, India.

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http://dx.doi.org/10.29252/beat-0701015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360008PMC
January 2019

Successful treatment of severe aplastic anemia with syngeneic stem cell transplantation in the setting of active disseminated mucormycosis.

Med Mycol Case Rep 2019 Mar 12;23:68-71. Epub 2019 Jan 12.

Bone Marrow Transplantation Program, Department of Internal Medicine, American University of Beirut, Medical Center, 113-6044 Beirut, Lebanon.

Severe aplastic anemia (SAA) is a hematological disease resulting in pancytopenia due to bone marrow failure. Treatment consists of immunosppressive therapy, or allo-SCT. Patients with aplastic anemia are predisposed to invasive fungal infections due to mucormycosis. Read More

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http://dx.doi.org/10.1016/j.mmcr.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349008PMC
March 2019
1 Read

Concurrent cerebral aspergillosis and abdominal mucormycosis during Ibrutinib therapy for chronic lymphocytic leukemia.

Clin Microbiol Infect 2019 Jan 28. Epub 2019 Jan 28.

Paris Descartes University, Infectious Diseases and Tropical Medicine Department, Necker-Enfants malades Hospital, AP-HP, IHU Imagine, Paris, France; Institut Pasteur, Centre National de la Recherche Scientifique, Unité de Mycologie Moléculaire, UMR 2000, Paris, France.

Peri et al reported a case of invasive aspergillosis with primary pulmonary involvement followed by central nervous system (CNS) involvement in a patient treated for chronic lymphocytic leukemia (CLL) with ibrutinib. In addition to their work, we describe a case of primary CNS aspergillosis involvement and abdominal mucormycosis in a patient treated with ibrutinib. Emerging fungal syndrome in patients with CLL receiving ibrutinib justifies the need for an exhaustive work-up for extrapulmonary involvement and invasive diagnosing procedures regarding the risk of dissemination and fungal co-infection. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.016DOI Listing
January 2019
1 Read

Fatal Invasive Gastrointestinal Fungal Infection in Three Non-immunocompromised Patients.

J Coll Physicians Surg Pak 2019 Feb;29(2):181-184

Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi, Pakistan.

The importance and frequency of invasive fungal infections in different organs, including the gastrointestinal tract, has increased due to excessive use of aggressive immunosuppressive and immunomodulatory drugs in malignant diseases and organ transplantations as well as increased infections with the human immunodeficiency virus (HIV). Fungal infections in the small intestine or colon are usually part of a disseminated disease process and reach these organs through the bloodstream. Two of the patients were infants 10 and 15 days of age, while one was 23 years old. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.02.181DOI Listing
February 2019
1 Read

Rapidly progressing ulcer and a urine drainage bag.

Dermatol Online J 2018 Nov 15;24(11). Epub 2018 Nov 15.

Dermatology, Ramon y Cajal Hospital, Carretera Colmenar Viejo km 9.100, 28034 Madrid.

Primary cutaneous mucormycosis is an opportunistic fungal infection caused by the order Mucorales, most frequently by the Rhizopus species. Both systemic factors, such as diabetes mellitus or malignancies and local factors disrupting the skin barrier are implicated in development of this entity. The initial manifestation is a red-to-black papule rapidly progressing to a necrotic and painful ulcer. Read More

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November 2018

Gastrointestinal mucormycosis in a child with acute lymphoblastic leukemia: An uncommon but ominous complication.

Indian J Cancer 2018 Jul-Sep;55(3):304-305

Department of Medical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.

Invasive fungal infections constitute a major cause of morbidity and mortality in children undergoing therapy for hematological malignancies. We report a 1-year-old boy who was receiving chemotherapy for acute lymphoblastic leukemia. His clinical course was complicated by a clinical syndrome consistent with neutropenic enterocolitis to which he succumbed. Read More

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http://dx.doi.org/10.4103/ijc.IJC_260_18DOI Listing
January 2019
2 Reads

Disseminated mucormycosis due to Lichtheimia corymbifera during ibrutinib treatment for relapsed chronic lymphocytic leukaemia: a case report.

Clin Microbiol Infect 2019 Feb 26;25(2):261-263. Epub 2018 Oct 26.

Laboratoire de Parasitologie et Mycologie Médicale, Centre Hospitalier Universitaire Hôtel Dieu, Nantes, France.

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http://dx.doi.org/10.1016/j.cmi.2018.10.004DOI Listing
February 2019

Managing mucormycosis in a resource-limited setting: challenges and possible solutions.

Trop Doct 2019 Jan 28:49475519825561. Epub 2019 Jan 28.

4 Associate Professor, Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

Mucormycosis is a potentially fatal fungal infection with high prevalence in poor-resource settings. Besides being an extremely expensive disease to treat, the challenges range from lack of experienced mycologists or mycology department to knowledge and availability of treatment regimes. Read More

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http://dx.doi.org/10.1177/0049475519825561DOI Listing
January 2019

Effects of Photodynamic Inactivation on the Growth and Antifungal Susceptibility of Rhizopus oryzae.

Mycopathologia 2019 Jan 28. Epub 2019 Jan 28.

Department of Dermatology, Zhongshan Hospital Fudan University, Shanghai, China.

Mucormycosis is an aggressive and high-mortality opportunistic fungal infection, especially in immunocompromised patients. Conventional antifungals or surgery showed a limited effect on this disease. The antimicrobial photodynamic therapy (aPDT) has been proven to be a promising therapeutic choice against multiple pathogenic fungi. Read More

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http://dx.doi.org/10.1007/s11046-019-00321-2DOI Listing
January 2019
1 Read

Rhino-orbital Mucormycosis presenting as facial cellulitis in a patient with high-risk acute myeloid leukemia in relapse.

Curr Res Transl Med 2019 Jan 24. Epub 2019 Jan 24.

Sorbonne Université, Université Pierre et Marie Curie, Paris, France; AP-HP, Hôpital Saint-Antoine, Service d'Hématologie Clinique, F-75012, Paris, France; INSERM, UMR S 938,Centre de Recherche Saint-Antoine (CRSA), F-75012 Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24523186193000
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http://dx.doi.org/10.1016/j.retram.2019.01.004DOI Listing
January 2019
3 Reads

Mucormycosis- a clinicoepidemiological review of cases over 10 years.

Mycoses 2019 Jan 27. Epub 2019 Jan 27.

Christian Medical College, Vellore, Tamil Nadu, India, 629004.

Background: Limited data exists for epidemiology and outcomes of various agents causing mucormycosis in various clinical settings from developing countries like India.

Objectives: To study the epidemiology and outcomes of various agents causing mucormycosis in different clinical settings in a tertiary care hospital from South India.

Patients And Methods: We reviewed details of 184 consecutive patients with culture proven mucormycosis with consistent clinical syndrome and supporting features from September 2005 to September 2015. Read More

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http://dx.doi.org/10.1111/myc.12897DOI Listing
January 2019
5 Reads

Rare Presentation of Mucormycosis in Aplastic Anaemia: Isolated Hepatic Mucormycosis.

Mycopathologia 2019 Jan 25. Epub 2019 Jan 25.

Department of Internal Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.

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http://dx.doi.org/10.1007/s11046-018-0309-yDOI Listing
January 2019
1.528 Impact Factor

Disseminated Mucormycosis with Positive Galactomannan.

Case Rep Infect Dis 2018 24;2018:4294013. Epub 2018 Dec 24.

Division of Infectious Diseases, Warren Alpert Medical School of Brown University, Providence, USA.

We describe a case of disseminated mucormycosis () diagnosed on autopsy, in a man who had been working in construction with undiagnosed neutropenia from hairy-cell leukemia, which is rarely associated with invasive mold infections. Galactomannan values in both blood and bronchoalveolar lavage were strongly positive. There is an unmet need for accurate noninvasive fungal diagnostic tests. Read More

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http://dx.doi.org/10.1155/2018/4294013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323503PMC
December 2018
1 Read

Two cases of Osteoarticular Mucor menace: A diagnostic and management conundrum.

Drug Discov Ther 2018 ;12(6):374-378

Department of Medicine, All India Institute of Medical Sciences.

Mucormycosis is an uncommon aggressive fungal infection usually seen in immunocompromised hosts or patients with burns and trauma. The common presentations include rhino-orbital-cerebral and pulmonary involvement. Osteoarticular involvement is a rare presentation of this disease. Read More

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http://dx.doi.org/10.5582/ddt.2018.01064DOI Listing
January 2018
1 Read

Invasive fungal infections in critically ill patients: A prospective study from a tertiary care hospital in India.

Drug Discov Ther 2018 ;12(6):363-367

Department of Medicine, All India Institute of Medical Sciences.

Invasive fungal infections (IFI) are commonly seen in immunosuppressed individuals but their epidemiology in critically ill patients has not been well described. The aim of this study was to determine the frequency, risk factors and outcome of invasive fungal infections in a medical intensive care unit. A prospective observational study was carried out between August 2016 and March 2018 in the medical intensive care unit. Read More

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http://dx.doi.org/10.5582/ddt.2018.01068DOI Listing
January 2018
2 Reads

Acute invasive fungal rhinosinusitis: our 2 year experience and outcome analysis.

Eur Arch Otorhinolaryngol 2019 Jan 22. Epub 2019 Jan 22.

Department of ENT, SDM College of Medical Sciences, Hubli-Dharwad, Karnataka, 680009, India.

Purpose: The incidence of Acute invasive fungal rhinosinusitis (AIFRS) is on the rise considering the multitude of comorbidities present in a single patient.The delay in suspecting the fungal etiology, presentation of the patient for an Otorhinolaryngology consult and lack of defined protocols affects outcome.This study looks in to the various aspects of treatment of AIFRS including sample collection, diagnosis and medicosurgical treatment. Read More

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http://link.springer.com/10.1007/s00405-019-05288-w
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http://dx.doi.org/10.1007/s00405-019-05288-wDOI Listing
January 2019
6 Reads
1.608 Impact Factor

Pulmonary mucormycosis associated with medical marijuana use.

Respir Med Case Rep 2019 9;26:176-179. Epub 2019 Jan 9.

Southern Illinois University School of Medicine, Springfield, IL, USA.

A 66-year-old man with diabetes presented to the hospital with a two-month history of dyspnea, cough, rust-colored sputum, night sweats and 20 pound weight loss. He had begun smoking medical marijuana 3 months earlier. CT of the chest showed multiple bilateral large ground glass opacities with surrounding consolidation. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330507PMC
January 2019

Comparative Analysis of Inflammatory Cytokine Release and Alveolar Epithelial Barrier Invasion in a Transwell Bilayer Model of Mucormycosis.

Front Microbiol 2018 8;9:3204. Epub 2019 Jan 8.

Division of Infectious Diseases, Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.

Understanding the mechanisms of early invasion and epithelial defense in opportunistic mold infections is crucial for the evaluation of diagnostic biomarkers and novel treatment strategies. Recent studies revealed unique characteristics of the immunopathology of mucormycoses. We therefore adapted an alveolar Transwell A549/HPAEC bilayer model for the assessment of epithelial barrier integrity and cytokine response to , and . Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2018.03204
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http://dx.doi.org/10.3389/fmicb.2018.03204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332705PMC
January 2019
3 Reads
3.941 Impact Factor

Successful Treatment of Eczema-Like Mucormycosis in a Child by Combination of Intravenous Drip and Percutaneous Injection Amphotericin B.

Mycopathologia 2019 Jan 22. Epub 2019 Jan 22.

Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

We report a case of eczema-like cutaneous mucormycosis caused by Rhizopus arrhizus. A 4-year-old child was presented to our hospital with a history of gradually enlarging papule and plaque in the periumbilical area for nearly 4 years since 2 weeks after his birth, and it has been misdiagnosed as eczema for nearly 3 years. Based on histopathology examination, the fungus culture test and DNA sequencing, it was revealed that R. Read More

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http://dx.doi.org/10.1007/s11046-018-0273-6DOI Listing
January 2019
4 Reads

Isolated Renal Mucormycosis in Immunocompetent Hosts: Clinical Spectrum and Management Approach.

Am J Trop Med Hyg 2019 Jan 14. Epub 2019 Jan 14.

Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Isolated renal mucormycosis in immunocompetent hosts is a rare entity. We present the largest case series of isolated renal mucormycosis in immunocompetent hosts. Retrospective data of isolated renal mucormycosis from March 2012 to June 2017 were reviewed. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0103DOI Listing
January 2019
1 Read

Impact of Prosthodontic Treatment on the Oral Health-related Quality of Life in Mucormycosis Patient: A Case Report.

Cureus 2018 Oct 24;10(10):e3493. Epub 2018 Oct 24.

Prosthodontics, Sri Ramachandra University, Chennai, IND.

Mucormycosis is a fulminant fungal infection that occurs most often in diabetic and immunocompromised patients, including those with hematologic malignancies. Patients with maxillary resections present a challenge situation for the maxillofacial prosthodontist. Prosthodontic rehabilitation of such patients presents a significant challenge in restoring speech, deglutition and mastication, and respiration. Read More

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https://www.cureus.com/articles/15624-impact-of-prosthodonti
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http://dx.doi.org/10.7759/cureus.3493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318130PMC
October 2018
4 Reads

An Emergent Entity: Indolent Mucormycosis of the Paranasal Sinuses. A Multicenter Study.

Int Arch Otorhinolaryngol 2019 Jan 24;23(1):92-100. Epub 2018 Oct 24.

Department of Pathology, Centro de Investigación y Docencia en Ciencias de la Salud (CIDOCS), Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, México.

 Indolent or chronic mucormycosis is a rare entity that affects both immunosuppressed and immunocompetent individuals. Additionally, its clinical evolution is nonspecific and there is no standardized treatment for this condition.  To describe the clinical characteristics and management of patients with indolent mucormycosis. Read More

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http://dx.doi.org/10.1055/s-0038-1667005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331311PMC
January 2019
1 Read

Biomarkers of fungal lung infection.

Curr Opin Infect Dis 2019 Jan 11. Epub 2019 Jan 11.

Intensive Care Medicine Department, Centro Hospitalar São João.

Purpose Of Review: The incidence of lung fungal infections, namely invasive pulmonary aspergillosis (IPA) and mucormycosis, is increasing in neutropenic and nonneutropenic patients. As they are a major cause of death, early diagnosis and antifungal therapy are crucial for outcome. The role of biomarkers in the management of this infections is the scope of this review. Read More

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http://dx.doi.org/10.1097/QCO.0000000000000523DOI Listing
January 2019
2 Reads

The contemporary management and clinical outcomes of mucormycosis: a systematic review and meta-analysis of case reports.

Int J Antimicrob Agents 2019 Jan 9. Epub 2019 Jan 9.

Centre for Medicine Use and Safety, Monash University, 381 Royal Pde, Parkville, VIC 3052, Australia; Pharmacy Department, Ballarat Health Services, 1 Drummon St N, Ballarat Central, VIC 3350, Australia; The National Centre for Antimicrobial Stewardship, The Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, VIC 3000, Australia. Electronic address:

The optimum treatment of mucormycosis with the advent of newer antifungals remains to be fully elucidated. This study aims to systematically evaluate the contemporary management and outcomes of mucormycosis. Cases of mucormycosis in patients ≥18 years old, published between January 2000 and January 2017 were identified through Ovid MEDLINE and Ovid EMBASE. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2019.01.002DOI Listing
January 2019

Therapeutic drug concentrations of isavuconazole following the administration of isavuconazonium sulfate capsules via gastro-jejunum tube: A case report.

Transpl Infect Dis 2019 Jan 13:e13048. Epub 2019 Jan 13.

Department of Pharmacy, Massachusetts General Hospital, Boston, Massachusetts.

Invasive fungal infections are a common complication in immunocompromised patients, such as organ transplant recipients. Isavuconazole is a broad-spectrum azole antifungal for the treatment of aspergillosis and mucormycosis. The package insert for isavuconazole recommends against opening the capsule for administration through enteral feeding tubes. Read More

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http://dx.doi.org/10.1111/tid.13048DOI Listing
January 2019
3 Reads

Case Series of Cutaneous Mucormycosis in Setting of Herpesviridae Infection.

Br J Dermatol 2019 Jan 11. Epub 2019 Jan 11.

Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Mucormycosis is an aggressive infection caused by an angioinvasive fungus that results in significant human disease. It most commonly manifests as rhinocerebral, pulmonary, and cutaneous infections. Among healthcare-associated mucormycosis, cutaneous manifestations are the most common, accounting for >50% of infections. Read More

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http://doi.wiley.com/10.1111/bjd.17631
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http://dx.doi.org/10.1111/bjd.17631DOI Listing
January 2019
8 Reads

In Vitro and In Vivo Evaluation of Voriconazole-Containing Antifungal Combinations against Mucorales Using a Model of Mucormycosis.

J Fungi (Basel) 2019 Jan 8;5(1). Epub 2019 Jan 8.

Consejo Nacional de Investigaciones Científicas y Tecnológicas CONICET, Laboratorio de Micología y Diagnóstico Molecular-Cátedra de Parasitología y Micología-Facultad de Bioquímica y Ciencias Biológicas-Universidad Nacional del Litoral, Santa Fe CP 3000, Argentina.

Mucorales are resistant to most antifungals. Mucormycosis associated mortality is unacceptable and new treatment approaches are needed. The objectives of this work were (i) to evaluate the nature and intensity of the in vitro effect of three drugs combinations which included voriconazole (plus amphotericin B, posaconazole and caspofungin) against 25 strains of six different Mucorales species; (ii) to evaluate a mucormycosis model; and (iii) to establish if any in vitro⁻in vivo correlation exists. Read More

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http://dx.doi.org/10.3390/jof5010005DOI Listing
January 2019

Correction to: Mucormycosis in hospitalized patients at a tertiary care center in Lebanon: a case series.

Infection 2019 Jan 7. Epub 2019 Jan 7.

Division of Infectious Diseases, American University of Beirut Medical Center, Riad El Solh, PO Box 11‑0236, Beirut, 1107 2020, Lebanon.

Unfortunately, the original version of this article contains mistakes. The names "Jean El-Cheikh" and Aline El Zakhem were spelled incorrectly. Read More

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http://dx.doi.org/10.1007/s15010-018-1259-5DOI Listing
January 2019
2.618 Impact Factor

Disseminated mucormycosis in an adolescent kidney transplant recipient.

Kidney Int 2019 Jan;95(1):236

First Department of Pediatrics, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183048
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http://dx.doi.org/10.1016/j.kint.2018.07.006DOI Listing
January 2019
8 Reads

Pulmonary mucormycosis with bronchial fistula successfully treated with bronchoscopic and medical therapy.

Int J Tuberc Lung Dis 2018 Dec;22(12):1525-1527

Department of Respiratory and Critical Care Medicine, First Hospital of China Medical University, Shenyang, China, hou_, Email:

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https://www.ingentaconnect.com/content/10.5588/ijtld.18.0420
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http://dx.doi.org/10.5588/ijtld.18.0420DOI Listing
December 2018
9 Reads
2.315 Impact Factor

Inpatient Mortality After Endoscopic Sinus Surgery for Invasive Fungal Rhinosinusitis.

Ann Otol Rhinol Laryngol 2018 Dec 25:3489418820871. Epub 2018 Dec 25.

2 Division of Otolaryngology - Head and Neck Surgery, University of California, San Diego, San Diego, CA, USA.

Objectives:: Invasive fungal rhinosinusitis is a rare, life-threatening condition that affects the paranasal sinuses. The standard of care after diagnosis includes surgical debridement and aggressive medical management. Despite treatment, mortality remains unacceptably high. Read More

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http://dx.doi.org/10.1177/0003489418820871DOI Listing
December 2018
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Nested polymerase chain reaction with specific primers for Mucorales in the serum of patients with hematological malignancies.

Jpn J Infect Dis 2018 Dec 25. Epub 2018 Dec 25.

Department of Hematology/Oncology, Research Hospital, Institute of Medical Science, University of Tokyo.

Mucormycosis is an opportunistic infection occurring in immunocompromised hosts with hematological malignancies. Mortality due to mucormycosis in patients with hematological malignancy is high. However, the clinical symptoms of mucormycosis are poorly characterized, and diagnosis is difficult due to the lack of specific culture or serological markers or antigens. Read More

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https://www.jstage.jst.go.jp/article/yoken/advpub/0/advpub_J
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http://dx.doi.org/10.7883/yoken.JJID.2018.379DOI Listing
December 2018
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Mucoromycosis and Wegner's Granulomatosis: A Case Report.

Iran J Public Health 2018 Nov;47(11):1763-1766

Dept. of Pathology, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Wegener's granulomatosis is a rare vasculitis affecting the upper and lower respiratory tracts and kidneys. The cornerstone of treatment in these patients is immunosuppressive therapy, which may predispose the patient to super-infections such as fungal diseases per se. However, the fungal infection mimics the clinical manifestations of Wegener's diseases would lead to neglected course of the infection and subsequent morbidity and mortality especially if unusual organs are involved. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294860PMC
November 2018
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Genetic tools for investigating Mucorales fungal pathogenesis.

Curr Clin Microbiol Rep 2018 Sep 18;5(3):173-180. Epub 2018 Jun 18.

South Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, the University of Texas at San Antonio, San Antonio, TX 78249, USA.

Purpose Of Review: Mucormycosis is an emerging opportunistic fungal infection whose causative agents are found within the Mucorales family. A recent increase in immunocompromised cohorts with solid organ transplants, diabetes mellitus, and other medical conditions have resulted in increased fungal infections including mucormycosis. Our current knowledge about Mucoralean fungi is in its infancy compared to other fungal pathogens, which may be due to lack of robust genetic tools for Mucorales. Read More

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http://link.springer.com/10.1007/s40588-018-0097-7
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http://dx.doi.org/10.1007/s40588-018-0097-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296817PMC
September 2018
9 Reads

Rhinocerebral mucormycosis after functional endoscopic sinus surgery: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13290

Department of Otolaryngology-Head and Neck Surgery.

Rationale: Mucormycosis is a rare fungal infection which mainly develops in compromised hosts and the associated mortality rate is high.

Patient Concerns: We report a case of mucormycosis in a 59-year-old woman following routine endoscopic sinus surgery. The patient had a history of diabetes mellitus (DM) and bronchial asthma. Read More

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http://dx.doi.org/10.1097/MD.0000000000013290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319933PMC
December 2018
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Presentation, etiology, and outcome of brain infections in an Indonesian hospital: A cohort study.

Neurol Clin Pract 2018 Oct;8(5):379-388

Departments of Neurology (DI, RE, KM, Sucipto, DO, DNL), Microbiology (DCL, A. Karuniawati), Radiology (REY, RM), Internal Medicine (EY, THK), Clinical Pathology (IST, DW), and Parasitology (RW, RA, A. Kurniawan), Cipto Mangunkusumo Hospital-Faculty of Medicine Universitas Indonesia; Eijkman Institute for Molecular Biology (UAJ, DS, KSAM); Eijkman-Oxford Clinical Research Unit (UAJ), Jakarta, Indonesia; Department of Internal Medicine and Radboud Center for Infectious Diseases (AvL, RvC), Radboud University Medical Center, Nijmegen, the Netherlands; TB/HIV Research Center (BA, SD, LC, ARG), Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; and Centre for Tropical Medicine and Global Health (RvC), Nuffield Department of Medicine, University of Oxford, UK.

Background: Little detailed knowledge is available regarding the etiology and outcome of CNS infection, particularly in HIV-infected individuals, in low-resource settings.

Methods: From January 2015 to April 2016, we prospectively included all adults with suspected CNS infection in a referral hospital in Jakarta, Indonesia. Systematic screening included HIV testing, CSF examination, and neuroimaging. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276332PMC
October 2018
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CRISPR-Cas9 induces point mutation in the mucormycosis fungus Rhizopus delemar.

Fungal Genet Biol 2018 Dec 15;124:1-7. Epub 2018 Dec 15.

Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA; Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA. Electronic address:

Rhizopus delemar causes devastating mucormycosis in immunodeficient individuals. Despite its medical importance, R. delemar remains understudied largely due to the lack of available genetic markers, the presence of multiple gene copies due to genome duplication, and mitotically unstable transformants resulting from conventional and limited genetic approaches. Read More

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http://dx.doi.org/10.1016/j.fgb.2018.12.002DOI Listing
December 2018
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Necrotic Herpes Simplex Virus Infection of the Nose and Orbit.

Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):e21-e22

Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, Tennessee, U.S.A.

This is the first reported case of necrotizing nasal and sinus herpes infection with orbital involvement. A 94-year-old male with a past medical history of hypertension, congestive heart failure, and chronic kidney disease presented with necrotic nasal cellulitis and a red left eye with blurry vision. Onset was 2 weeks prior with an upper lip fever blister. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001288DOI Listing
December 2018
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Breaking the mold: A case of pulmonary mucormycosis treated with isavuconazole.

Med Mycol Case Rep 2019 Mar 1;23:34-36. Epub 2018 Dec 1.

Weill Cornell Medicine, 1300 York avenue, New York, NY 10065, Unites States.

Pulmonary mucormycosis is a rare opportunistic invasive fungal infection that disproportionately affects immunocompromised hosts and carries high morbidity and mortality. It is traditionally treated with combined pharmacologic and surgical modalities. Here we present a case of pulmonary mucormycosis in a patient whose disease burden precluded surgical management, and in whom acute kidney injury necessitated therapy with an alternative to the recommended pharmacologic antifungal therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22117539183011
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http://dx.doi.org/10.1016/j.mmcr.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290088PMC
March 2019
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A case of pulmonary mucormycosis presented as Pancoast syndrome and bone destruction in an immunocompetent adult mimicking lung carcinoma.

J Mycol Med 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology, Zhejiang Hospital, 12, Lingyin road, 310013 Hangzhou, China. Electronic address:

Pulmonary mucormycosis is a rare opportunistic infection caused by Mucormycosis. This fungal infection is uncommon in immunocompetent individuals. Because of its various clinical and imaging manifestations, it is a diagnostic challenge to distinguish pulmonary mucormycosis from other pulmonary diseases, such as carcinoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11565233173045
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http://dx.doi.org/10.1016/j.mycmed.2018.10.005DOI Listing
December 2018
8 Reads