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Pathol Res Pract 2022 Jun 17;236:153981. Epub 2022 Jun 17.

Department of Pathology, PSG Institute of Medical Sciences and Research, Coimbatore, India. Electronic address:

Introduction: Due to Corona Virus disease -19, India saw a surge of mucormycosis cases, associated with high death rate. India, during the month of May to July 2021 saw a surge of mucormycosis from all states, with close to 50,000 cases just in a span of 3 months.

Objective: To examine the histopathological appearances of rhino-orbital/rhino-maxillary/sino-nasal mucormycosis in the backdrop of the ongoing COVID 19 pandemic. Read More

Radiol Case Rep 2022 Sep 17;17(9):2956-2959. Epub 2022 Jun 17.

Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Coronavirus 2019 infection (COVID-19) has a broad spectrum of clinical complications, some unrecognized. Herein, a case of a diabetic patient with multiple episodes of hemoptysis 2 months following her recovery from SARS-CoV-2 infection is reported. The initial computed tomography (CT scan) revealed the left lower lobe collapsed secondary to bronchial narrowing and obliteration. Read More

Curr Med Mycol 2021 Dec;7(4):19-27

Department of Pathology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Background And Purpose: The healthcare system in India collapsed during the second wave of the COVID-19 pandemic. A fungal epidemic was announced amid the pandemic with several cases of COVID-associated mucormycosis and pulmonary aspergillosis being reported. However, there is limited data regarding mixed fungal infections in COVID-19 patients. Read More

Microorganisms 2022 Jun 13;10(6). Epub 2022 Jun 13.

Department of Otolaryngology and Head-Neck Surgery, All India Institute of Medical Sciences, New Delhi 110029, India.

(1) Background: During the second wave of COVID-19, India faced a rapid and sudden surge of not only COVID19-delta variant cases but also mucormycosis, making the infection even more fatal. We conducted a study to determine factors associated with the occurrence of mucormycosis in patients with COVID-19. (2) Methods: This case-control study comprised 121 patients; 61 cases (mucormycosis with COVID-19) and 60 controls. Read More

Sci Rep 2022 Jun 23;12(1):10649. Epub 2022 Jun 23.

Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo (UMSNH), Morelia, Michoacán, Mexico.

Mucormycosis is a fungal infection caused by Mucorales, with a high mortality rate. However, only a few virulence factors have been described in these organisms. This study showed that deletion of rfs, which encodes the enzyme for the biosynthesis of rhizoferrin, a siderophore, in Mucor lusitanicus, led to a lower virulence in diabetic mice and nematodes. Read More

Ann Med Surg (Lond) 2022 Jun 1;78:103889. Epub 2022 Jun 1.

Thoracic Surgery Department, Al-Ahli Hospital, Palestine.

Mucormycosis is a rare fungal infection mostly encountered in immunosuppressed patients. Other major risk factors are diabetes mellitus, solid organ transplant and chronic use of glucocorticoids. Early diagnosis should be obtained as soon as possible due to the infection's aggressive behavior and high probability of dissemination. Read More

J Neurosurg Case Lessons 2022 Jun 20;3(25):CASE21567. Epub 2022 Jun 20.

Clinic of Neurosurgery, University Hospital Heidelberg, Baden-Württemberg, Germany; and.

Background: In this case report the authors present two female patients with intracranial mucormycosis after coronavirus disease 2019 (COVID-19).

Observations: The first patient was a 30-year-old woman with no past medical history or allergies who presented with headaches and vomiting. Magnetic resonance imaging (MRI) and computed tomography of the skull showed an endonasal infection, which had already destroyed the frontal skull base and caused a large frontal intracranial abscess. Read More

Maedica (Bucur) 2022 Mar;17(1):103-106

Department of Dentistry, BLDEDU, Vijayapura Karnataka, India.

Mucormycosis is one of the most lethal and rapidly spreading fungal infection which is caused by fungus of the order . The swiftness of spreading and high mortality rate that characterize mucormycosis cases added more burden to the enormous challenge brought by the Covid-19 pandemic globally. The aim of this article is to identify and discuss mucormycosis and review the literature related to its diagnosis and management. Read More

Maedica (Bucur) 2022 Mar;17(1):215-225

Department of Infectious Diseases, "Dr. Victor Babes" Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania.

COVID-19 has proven to be an independent risk factor for secondary infectious complications. Amongst them, mucormycosis has recently been noticed more frequently than in the past. Caused by molds belonging to the order, this is a rare, but potentially fatal infection unless adequately treated. Read More

Cureus 2022 May 18;14(5):e25124. Epub 2022 May 18.

Infectious Diseases, East Tennessee State University - Quillen College of Medicine, Johnson City, USA.

Mucormycosis is a destructive, necrotizing, and potentially fatal fungal disease that usually affects immunocompromised or diabetic patients. Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis is a rare, aseptic necrotizing, granulomatous vasculitis affecting small- to medium-sized vessels, resulting in systemic manifestations. Here, we present a case of a 46-year-old gentleman with overlapping features of mucormycosis and GPA, that was successfully treated with isavuconazole monotherapy. Read More

Sci Rep 2022 Jun 21;12(1):10494. Epub 2022 Jun 21.

Department of Internal Medicine and Critical Care, Faculty of Medicine, Assuit University, Assiut, 71515, Egypt.

Mucormycosis is a life-threatening opportunistic angioinvasive fungal infection. We aimed to describe the frequency, presentations, predictors, and in-hospital outcome of mucormycosis patients in the scope of CoronaVirusDisease-19 (COVID-19) during the third viral pandemic wave. This cross-sectional retrospective study included all patients who fulfilled the criteria of mucormycosis with concurrent confirmed covid19 infection admitted to Assuit University Hospital between March 2021 and July 2021. Read More

Mycopathologia 2022 Jun 21. Epub 2022 Jun 21.

Department of Pulmonary Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Sector-12, Chandigarh, 160012, India.

Background: In experimental models, the expression of glucose-regulated protein 78 (GRP78) in endothelial cells played a role in the pathogenesis of mucormycosis. However, the role of GRP78 in COVID-19-associated mucormycosis (CAM) has not been studied. We hypothesized that serum GRP78 levels are elevated in subjects with CAM. Read More

Mycoses 2022 Jun 20. Epub 2022 Jun 20.

Department of Pulmonary Medicine, Postgraduate institute of medical education and Research, Chandigarh, India.

Background: Several hypotheses have been proposed for explaining the outbreak of coronavirus disease 2019 (COVID-19)-associated mucormycosis in India, including the burning of cattle dung cakes, though no study has yet been conducted to support this claim.

Methods: We conducted an aero-mycological study to evaluate whether Mucorales in the air increased during or after burning cattle dung cakes. We further compared the growth of Mucorales in the indoor air samples from houses with and without cattle. Read More

Int J Surg Case Rep 2022 Jun 10;96:107297. Epub 2022 Jun 10.

ENT Department, Al-Farwaniya Hospital, Al-Farwaniya, Kuwait.

Introduction And Importance: Mucormycosis is rare type of infection yet, it is common in patient with Diabetes Mellitus and immune deficiencies. Mucormycosis mostly target the rhino-orbito-cerebral region, hence the common presenting symptoms are nasal symptoms followed by orbito-cerebral symptoms.

Case Presentation: Here, we present a diabetic lady with unusual presentation of mucormycosis. Read More

IJID Reg 2022 Mar 24;2:99-106. Epub 2021 Dec 24.

Department of Gastroenterology, AIG Hospitals, Hyderabad, Telangana, India.

Background: Opportunistic cases of rhino-orbito-cerebral mucormycosis (ROCM) have increased in India during the coronavirus disease 2019 (COVID-19) pandemic.

Aim: To study laboratory parameters, histopathological features of sinus mucosal biopsies and exenterated orbit specimens, and clinical aspects of patients with ROCM.

Materials And Methods: Retrospective analysis of nasal and sinus debridement biopsies and orbital exenteration specimens of 30 patients was undertaken, along with analysis of laboratory parameters, clinical history of predisposing conditions, and medication history during COVID-19. Read More

Clin Ophthalmol 2022 11;16:1933-1940. Epub 2022 Jun 11.

Department of Ophthalmology, Faculty of Medicine, Tanta University, Tanta, Gharbeya, Egypt.

Purpose: To construct a simple management algorithm for cases with orbital mucormycosis during the COVID-19 era.

Methods: Retrospective study included records of 30 Egyptian patients with post COVID-19 orbital mucormycosis. They underwent full clinical examination, laboratory investigations, Computed tomography (CT)/magnetic resonance imaging (MRI) of the paranasal sinuses and pathological specimen examination. Read More

Front Immunol 2022 26;13:863234. Epub 2022 May 26.

Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.

Mucormycosis is a potentially fatal illness that arises in immunocompromised people due to diabetic ketoacidosis, neutropenia, organ transplantation, and elevated serum levels of accessible iron. The sudden spread of mucormycosis in COVID-19 patients engendered massive concern worldwide. Comorbidities including diabetes, cancer, steroid-based medications, long-term ventilation, and increased ferritin serum concentration in COVID-19 patients trigger favorable fungi growth that in turn effectuate mucormycosis. Read More

Front Immunol 2022 1;13:900522. Epub 2022 Jun 1.

Centre for Infectious Diseases and Tropical Medicine, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique -Hôpitaux de Paris, Université de Paris, Paris, France.

Invasive fungal diseases (IFD) still cause substantial morbidity and mortality, and new therapeutic approaches are urgently needed. Recent data suggest a benefit of checkpoint inhibitors (ICI). We report the case of a diabetic patient with refractory IFD following a SARSCoV-2 infection treated by ICI and interferon-gamma associated with antifungal treatment. Read More

Cureus 2022 May 16;14(5):e25034. Epub 2022 May 16.

Clinical Neurosciences, University of the East Ramon Magsaysay Memorial Medical Center, Quezon City, PHL.

Cavernous sinus thrombophlebitis is a rare, potentially life-threatening, condition that is most often caused by gram-negative bacteria and, to a lesser extent, fungi. is an opportunistic fungus that frequently affects patients with a weak immune system. We describe a case of an adult female without diabetes who developed sphenoid sinusitis causing cavernous sinus thrombophlebitis. Read More

Cureus 2022 May 14;14(5):e24986. Epub 2022 May 14.

Clinical Sciences, Eastern University of Sri Lanka, Batticaloa, LKA.

In a fast-evolving COVID-19 pandemic, co-infection with mucormycosis has been reported in some parts of the world. It is still unknown whether one of the either diseases makes the patient susceptible to developing the other. The co-occurrence of them significantly elevates the mortality risk and is commonly reported in immunocompromised individuals. Read More

Mycoses 2022 Jun 17. Epub 2022 Jun 17.

National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan.

Background: Epidemiological knowledge of mucormycosis obtained from national population-based databases is scarce.

Objectives: This study aimed to depict the disease burden and demographics of mucormycosis in Taiwan by using the Taiwan National Health Insurance Research Database (NHIRD) and those of aspergillosis as a comparator.

Methods: Data from patients with either mucormycosis or aspergillosis from 2006-2017 identified with the International Classification of Diseases (ICD) codes were extracted from the NHIRD. Read More

J Pak Med Assoc 2022 05;72(5):1017

4th Year MBBS Student, Dow University of Health Sciences, Karachi, Pakistan.

Front Pediatr 2022 27;10:831363. Epub 2022 May 27.

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Cunninghamellamycosis is an unusual but often highly fatal mucormycosis caused by , which belongs to the basal lineage order Mucorales. It is especially fatal when the central nervous system is involved. So far, there are few reported cases of surgical treatment for intracranial mucormycosis in children after allogeneic haematopoietic stem cell transplantation (HSCT). Read More

J Maxillofac Oral Surg 2022 Jun 31;21(2):297-306. Epub 2020 Jul 31.

Mexico City, Mexico.

Background: Temporal muscle has great versatility to cover defects, caused by resections or large soft tissue losses of the middle facial third, has been used for more than 100 years. In the skin, the temporal muscle is transformed by the phenomenon called skin dermalization and mucolization in the oral cavity.

Purpose: This article shows how the temporal muscle is divided into two segments (bipartition) or three segments (tripartition) achieving a transposition of the muscle to cover large empty spaces caused by orbital exenteration or in maxilectomy. Read More

J Maxillofac Oral Surg 2022 Jun 21;21(2):739-742. Epub 2022 Feb 21.

Dept of ENT and Head and Neck Surgery, Baroda Medical College, S.S.G. Hospital, M.S. University, Vadodara, Gujarat India.

Introduction: Recent advances in endoscopic paraphernalia have brought the once intricate anterior lateral wall of maxilla, within reach of the endoscopic surgeon. Endoscopic modified Denker's approach provides another route to reach the indiscernible sites of maxillary & other paranasal sinuses along with PPF (pterygo-palatine fossa)/ITF (infra-temporal fossa) region. This approach has been widely used Pan-India during the Post-Covid Mucormycosis Epidemic, in our country. Read More

JTCVS Tech 2022 Jun 18;13:244-246. Epub 2022 Apr 18.

Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif.

Med Mycol 2022 Jun 16. Epub 2022 Jun 16.

Consultant, Infectious Diseases Department, Sterling Hospital, Ahmedabad, 380052, India.

The COVID-19 pandemic had led to an increase surge of mucormycosis in COVID-19 patients, especially in India. Diabetes and irrational usage of corticosteroid to treat COVID-19 were some of the factors implicated for COVID-19 associated mucormycosis (CAM). We designed this case control study to identify risk factors for mucormycosis in COVID-19 patients. Read More

Cureus 2022 May 12;14(5):e24932. Epub 2022 May 12.

Internal Medicine, Hospital Professor Doutor Fernando Fonseca, Amadora, PRT.

Mucormycosis is a severe fungal infection that occurs mainly in immunocompromised patients. It is characterized by several syndromes with rhino-orbito-cerebral and pulmonary involvement. We report the case of a 49-year-old patient admitted for diabetic ketoacidosis and Influenza B pneumonia nonresponsive to treatment, which was later diagnosed with pulmonary mucormycosis. Read More

Pediatr Infect Dis J 2022 Jun 13. Epub 2022 Jun 13.

From the Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht.

Background: Mucormycosis is classified as the third leading cause of invasive fungal disease in immunocompromised patients and is characterized by high morbidity and mortality (33%-56%). The aim of this study is to describe presentation, treatment and outcome of Dutch pediatric hemato-oncology patients recently diagnosed with mucormycosis and to review the literature to gain more insight specifically into contemporary outcome data.

Methods: Ten cases were diagnosed in the Princess Máxima Center for Pediatric Oncology from 2018 to 2021 and were retrospectively reviewed. Read More

J Stomatol Oral Maxillofac Surg 2022 Jun 11. Epub 2022 Jun 11.

Post Graduation Program in Dentistry, Universidade Federal da Paraíba (UFPB), Campus I - Cidade Universitária, João Pessoa, Paraíba 58033-455, Brazil.

This paper aims to discuss clinical aspects of mucormycosis. This case series was conducted in two services, comprising six mucormycosis cases during COVID-19 pandemic. About gender, there are 4 (66. Read More