4,428 results match your criteria Mucormycosis


Rhino-orbital-cerebral mucormycosis.

CMAJ 2019 Apr;191(16):E450

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan

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http://www.cmaj.ca/lookup/doi/10.1503/cmaj.181210
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http://dx.doi.org/10.1503/cmaj.181210DOI Listing
April 2019
1 Read

Role of Arf-like proteins (Arl1 and Arl2) of Mucor circinelloides in virulence and antifungal susceptibility.

Fungal Genet Biol 2019 Apr 20. Epub 2019 Apr 20.

Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, 58038 Morelia, Michoacán, México. Electronic address:

Mucor circinelloides is an etiologic agent of mucormycosis, a fungal infection produced by Mucorales often associated with mortality due to unavailability of antifungal drugs. Arl proteins belong to the Arf family and are involved in vesicle trafficking and tubulin assembly. This study identified two Arl (Arf-like)-encoding genes, arl1 and arl2, in M. Read More

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http://dx.doi.org/10.1016/j.fgb.2019.04.011DOI Listing

Gastrointestinal microbiota alteration induced by Mucor circinelloides in a murine model.

J Microbiol 2019 Apr 22. Epub 2019 Apr 22.

South Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USA.

Mucor circinelloides is a pathogenic fungus and etiologic agent of mucormycosis. In 2013, cases of gastrointestinal illness after yogurt consumption were reported to the US FDA, and the producer found that its products were contaminated with Mucor. A previous study found that the Mucor strain isolated from an open contaminated yogurt exhibited virulence in a murine systemic infection model and showed that this strain is capable of surviving passage through the gastrointestinal tract of mice. Read More

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http://link.springer.com/10.1007/s12275-019-8682-x
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http://dx.doi.org/10.1007/s12275-019-8682-xDOI Listing
April 2019
1 Read

Gastric Mucormycosis in a Renal Transplant Patient Treated with Isavuconazole Monotherapy.

Case Rep Transplant 2019 17;2019:9839780. Epub 2019 Mar 17.

Department of Nephrology, Hypertension and Transplant Medicine, Augusta University Health, Augusta, GA, USA.

Gastrointestinal mucormycosis is a rare infection in solid organ transplant recipients. Our patient, a 79-year-old male, presented with severe dysphagia and odynophagia about 2 weeks after receiving a renal transplant. An upper gastrointestinal (UGI) endoscopy revealed esophagitis and gastric ulceration, the cultures from which grew Rhizopus species. Read More

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http://dx.doi.org/10.1155/2019/9839780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441519PMC

Fungal Infections of the Stem Cell Transplant Recipient and Hematologic Malignancy Patients.

Infect Dis Clin North Am 2019 Jun;33(2):545-566

Department of Internal Medicine, Division of Infectious Diseases, University of California Davis Medical Center, 4150 V Street, Suite G500, Sacramento, CA 96817, USA; Department of Medical Microbiology and Immunology, University of California - Davis, One Shields Avenue, Tupper Hall, Davis, CA 95616, USA. Electronic address:

Despite advances in chemotherapy and supportive care, morbidity and mortality remain high for patients with hematologic malignancies (HMs). Those who require hematopoietic stem cell transplantation (HSCT) often require significant immunosuppression and are subject to a variety of complications. These patients carry multiple risk factors for infectious complications, including the development of invasive fungal infections, compared with the general population. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915520193000
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http://dx.doi.org/10.1016/j.idc.2019.02.006DOI Listing
June 2019
1 Read

Fungal Rhinosinusitis: Unravelling the Disease Spectrum.

Authors:
Virendra Singh

J Maxillofac Oral Surg 2019 Jun 28;18(2):164-179. Epub 2019 Jan 28.

Department of Oral and maxillofacial Surgery, PGIDS, Pt. BD Sharma University of Health Sciences, Rohtak, Haryana 124001 India.

Fungal rhinosinusitis (FRS), once considered a rare disease, has seen a steep rise in incidence in recent times. This global rise in the burden of fungal disease is a consequence of an increment in the population with weakened immune systems. Increased life expectancy with rise in conditions like diabetes mellitus, medical advancements with invasive interventions, use of immunosuppressive drugs and chemo-radiotherapy all lead to unique risk situations. Read More

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http://link.springer.com/10.1007/s12663-018-01182-w
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http://dx.doi.org/10.1007/s12663-018-01182-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441414PMC
June 2019
4 Reads

Mucor menace in an immunocompetent young male after dental manipulation.

J Family Med Prim Care 2019 Feb;8(2):757-759

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

Fungal rhino-orbital sinusitis due to mucormycetes is a rapidly progressive condition with high mortality, rarely seen in immunocompetent individuals. A 26-year-old immunocompetent male presented with rhino-orbital mucormycosis after a history of dental manipulation. The patient was successfully managed with a combination of surgery, amphotericin B, and posaconazole. Read More

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http://www.jfmpc.com/text.asp?2019/8/2/757/253033
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http://dx.doi.org/10.4103/jfmpc.jfmpc_412_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436271PMC
February 2019
1 Read

Mucormycotic osteomyelitis of maxilla following maxillofacial trauma: The disease of the diseased.

J Family Med Prim Care 2019 Feb;8(2):748-750

Department of Dentistry, Subdivisional Hospital, Ranchi, Jharkhand, India.

Mucormycosis is a rare opportunistic fungal infection with acute, aggressive, and invasive nature, seen in immunocompromised/debilitated patients, especially with diabetes mellitus. The key to successful therapy is the early diagnosis of signs and symptoms of the disease, correction of the underlying medical disorder(s), and aggressive medical and surgical intervention. The case presented here is mucormycotic osteomyelitis of the nasomaxillary-zygomatic complex following trauma in a middle-aged man. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_410_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436305PMC
February 2019
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Overview And Outcome Of Mucormycosis Among Children With Cancer; Report From The Children's Cancer Hospital Egypt.

Mycoses 2019 Apr 14. Epub 2019 Apr 14.

Pediatric Oncology department, National cancer institute - Cairo University, Children Cancer Hospital, 57357.

Mucormycosis represents a real challenge in immunocompromised patients. This study aimed to describe the clinical characteristics, treatment outcome and infection-related mortality in our patients at the children's cancer hospital 57357, Cairo, Egypt.This is a retrospective study during the period 2007-2017. Read More

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http://dx.doi.org/10.1111/myc.12915DOI Listing
April 2019
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An aero mycological analysis of Mucormycetes in indoor and outdoor environments of northern India.

Med Mycol 2019 Apr 13. Epub 2019 Apr 13.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Mucormycosis is an angio-invasive infection, predominantly acquired by inhalation of sporangiospores from the environment. However, the burden of Mucormycetes sporangiospores in the air is not well studied. We aimed to estimate the burden of Mucormycetes spores in the outdoor and indoor (hospital) environment across different seasons in north India. Read More

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http://dx.doi.org/10.1093/mmy/myz031DOI Listing

Invasive fungal consecutive infections in a patient with acute myeloid leukaemia.

Niger J Clin Pract 2019 Apr;22(4):582-584

Department of Infectious Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

A woman with AML who became febrile and neutropenic after chemotherapy. At the first, Aspergillus was isolated from a sinus biopsy. After 4 weeks, while she was taking voriconazole, another episode of fever combined with dry coughs was detected. Read More

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http://dx.doi.org/10.4103/njcp.njcp_359_17DOI Listing
April 2019
2 Reads

Diagnosis of Rhinocerebral Mucormycosis by Treatment of Cavernous Right Internal Carotid Artery Occlusion With Mechanical Thrombectomy: Special Case Presentation and Literature Review.

Front Neurol 2019 26;10:264. Epub 2019 Mar 26.

Department of Neurosurgery, Arrowhead Regional Medical Center, Colton, CA, United States.

Mucormycosis is a rapidly progressive, angioinvasive fungal infection that has a predilection for the paranasal sinuses and adjacent mucosa. Rhinocerebral mucormycosis (RCM) is the most common form and is known to invade the skull base and its associated blood vessels-leading to mycotic aneurysms, ischemic infarcts, and intracerebral hemorrhage. There are documented cases of mechanical thrombectomy in ischemic stroke due to RCM, however, there are no known cases that were diagnosed primarily by histological and pathological analysis of the embolus. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00264
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http://dx.doi.org/10.3389/fneur.2019.00264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443639PMC
March 2019
3 Reads

Unsuspected invasive gastrointestinal mucormycosis masquerading as inflammatory bowel disease: A pathologist's perspective.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):332-334

Department of Pathology, Columbia Asia Hospital, Hebbal, Bengaluru, Karnataka, India.

Mucormycosis is caused by fungi of the order Mucorales and class Zygomycetes. It is a rare opportunistic infection frequently associated with immunocompromised status. It can be disseminated disease or localized, which includes rhinocerebral, pulomonary, cutaneous, and gastrointestinal mucormycosis. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_240_18DOI Listing

Rhinocerebral mucormycosis associated with actinomycosis in a diabetic patient: A rare presentation.

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):122-125

Department of Oral Pathology and Microbiology, Mamata Dental College, Khammam, Telangana, India.

Mucormycosis is an opportunistic fulminant fungal infection which mainly affects the immunocompromised individuals. It begins in the nose and paranasal sinuses due to the inhalation of fungal spores. The common predisposing factors include diabetes mellitus and immunosuppression. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_77_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421906PMC
February 2019
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Teaching NeuroImages: Mucormycosis-associated vasculitis: A new sequence to show an old invasive infection.

Neurology 2019 Apr;92(15):e1796-e1797

From the Departments of Radiology (L.d.M.F., N.A.d.S., F.R.) and Pathology (A.A.), State University of Campinas; and Diagnósticos da America-DASA Group (N.A.d.S.), São Paulo, Brazil.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000007275DOI Listing
April 2019
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Next-generation sequencing for hypothesis-free genomic detection of invasive tropical infections in poly-microbially contaminated, formalin-fixed, paraffin-embedded tissue samples - a proof-of-principle assessment.

BMC Microbiol 2019 Apr 8;19(1):75. Epub 2019 Apr 8.

Institute for Microbiology, Virology and Hygiene, University Medicine Rostock, Schillingallee 70, 18057, Rostock, Germany.

Background: The potential of next-generation sequencing (NGS) for hypothesis-free pathogen diagnosis from (poly-)microbially contaminated, formalin-fixed, paraffin embedded tissue samples from patients with invasive fungal infections and amebiasis was investigated. Samples from patients with chromoblastomycosis (n = 3), coccidioidomycosis (n = 2), histoplasmosis (n = 4), histoplasmosis or cryptococcosis with poor histological discriminability (n = 1), mucormycosis (n = 2), mycetoma (n = 3), rhinosporidiosis (n = 2), and invasive Entamoeba histolytica infections (n = 6) were analyzed by NGS (each one Illumina v3 run per sample). To discriminate contamination from putative infections in NGS analysis, mean and standard deviation of the number of specific sequence fragments (paired reads) were determined and compared in all samples examined for the pathogens in question. Read More

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http://dx.doi.org/10.1186/s12866-019-1448-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454699PMC
April 2019
1 Read

Isavuconazole prophylaxis in patients with hematologic malignancies and hematopoietic-cell transplant recipients.

Clin Infect Dis 2019 Apr 8. Epub 2019 Apr 8.

Division of Infectious Diseases, Oregon Health and Science University, Portland, Oregon, USA.

Background: Isavuconazole (ISA) is an attractive candidate for primary mold-active prophylaxis in high-risk patients with hematologic malignancies (HM) or hematopoietic-cell transplant (HCT) recipients. However, data supporting the use of ISA for primary prophylaxis in these patients is lacking.

Methods: We conducted a retrospective review of breakthrough invasive fungal infections (bIFIs) among adult HM patients and HCT recipients who received ≥ 7 days of ISA primary prophylaxis between 9/1/2016 and 9/30/2018. Read More

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http://dx.doi.org/10.1093/cid/ciz282DOI Listing
April 2019
2 Reads
8.886 Impact Factor

Pseudomonas aeruginosa inhibits Rhizopus microsporus germination through sequestration of free environmental iron.

Sci Rep 2019 Apr 5;9(1):5714. Epub 2019 Apr 5.

Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK.

Rhizopus spp are the most common etiological agents of mucormycosis, causing over 90% mortality in disseminated infection. Key to pathogenesis is the ability of fungal spores to swell, germinate, and penetrate surrounding tissues. Antibiotic treatment in at-risk patients increases the probability of the patient developing mucormycosis, suggesting that bacteria have the potential to control the growth of the fungus. Read More

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http://dx.doi.org/10.1038/s41598-019-42175-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450908PMC
April 2019
1 Read

Inter-laboratory analysis of Isavuconazole plasma concentration assays among European laboratories.

Ther Drug Monit 2019 Mar 31. Epub 2019 Mar 31.

Basilea Pharmaceutica International Ltd., Basel, Switzerland.

Background: Under certain circumstances, clinicians treating patients with isavuconazole for invasive aspergillosis or mucormycosis may use therapeutic drug monitoring. However, the accuracy and reproducibility of the various assays used by different laboratories for the quantification of isavuconazole plasma concentrations have yet to be determined.

Methods: Human plasma samples spiked with known concentrations of isavuconazole were provided to 27 European laboratories that took part in a "round-robin" test (an inter-laboratory test performed independently at least two times; two rounds performed in the current study). Read More

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http://dx.doi.org/10.1097/FTD.0000000000000632DOI Listing
March 2019
4 Reads

Correlation of fungal cultures from non-sterile sites and Galactomannan assay with the diagnosis of aspergillosis and mucormycosis based on sterile culture results and histopathologic findings.

Infect Dis (Lond) 2019 May 2;51(5):373-376. Epub 2019 Apr 2.

c Department of Pathology, Asan Medical Center , University of Ulsan College of Medicine , Seoul , Republic of Korea.

Background: Data on whether positive non-sterile fungal culture has the same clinical value as a positive galactomannan (GM) result are limited.

Methods: Patients with biopsy-proven invasive aspergillosis or mucormycosis (over an 8-year period) in whom the results of GM and fungal culture of sputum and/or sinus aspirates were available were enrolled. Biopsy-proven cases were defined if fungal culture from a sterile biopsy specimen gave a positive result and/or hyphae were demonstrated by immunohistochemical staining for aspergillosis and mucormycosis. Read More

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http://dx.doi.org/10.1080/23744235.2019.1590632DOI Listing
May 2019
2 Reads

Animal Models to Study Mucormycosis.

Authors:
Ilse D Jacobsen

J Fungi (Basel) 2019 Mar 27;5(2). Epub 2019 Mar 27.

Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology (Hans Knöll Institute), Beutenbergstrasse 11a, 07745 Jena, Germany.

Mucormycosis is a rare but often fatal or debilitating infection caused by a diverse group of fungi. Animal models have been crucial in advancing our knowledge of mechanisms influencing the pathogenesis of mucormycoses, and to evaluate therapeutic strategies. This review describes the animal models established for mucormycosis, summarizes how they have been applied to study mucormycoses, and discusses the advantages and limitations of the different model systems. Read More

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http://dx.doi.org/10.3390/jof5020027DOI Listing
March 2019
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In vitro interactions between isavuconazole and tacrolimus, cyclosporin A or sirolimus against Mucorales.

J Antimicrob Chemother 2019 Apr 1. Epub 2019 Apr 1.

Université Paris Descartes, Faculté de Médecine, AP-HP, Hôpital Européen Georges Pompidou, Unité de Parasitologie-Mycologie, F-75015 Paris, France.

Objectives: To evaluate the in vitro interactions of isavuconazole with immune suppressors (tacrolimus, cyclosporin A or sirolimus) against 30 Mucorales isolates belonging to the most common species responsible for mucormycosis in humans (Rhizopus arrhizus, Rhizopus delemar, Rhizopus microsporus, Lichtheimia corymbifera, Lichtheimia ramosa, Mucor circinelloides and Rhizomucor pusillus).

Methods: In vitro interaction was evaluated by a microdilution chequerboard technique.

Results: Combination of isavuconazole with tacrolimus, cyclosporin A or sirolimus, was synergistic for 50%, 46% and 7% of the isolates, respectively. Read More

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http://dx.doi.org/10.1093/jac/dkz102DOI Listing
April 2019
2 Reads

Bowel infarction due to mucormycosis in an immunocompromised patient.

Med Mal Infect 2019 Mar 28. Epub 2019 Mar 28.

Department of digestive, hepato-biliary, and endocrine surgery, CHRU de Nancy, CHRU Brabois, rue du Morvan, 54511 Vandoeuvre-lès-Nancy, France.

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http://dx.doi.org/10.1016/j.medmal.2019.03.005DOI Listing
March 2019
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Mucormycosis as the Elusive Cause of an Aortic Thrombus and Tissue-Obliterating Abscess.

Case Rep Hematol 2019 19;2019:4842150. Epub 2019 Feb 19.

Department of Hematology-Oncology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134, USA.

Invasive mucormycosis is an increasingly common cause of morbidity and mortality in hematologic malignancy patients. Early consideration of the diagnosis is essential in at-risk patients, exhibiting suggestive signs and symptoms. A 56-year-old female with acute myeloid leukemia initially presented with neutropenic fever before subsequently developing dense hemiplegia due to septic emboli to the spine and multifocal abscesses. Read More

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http://dx.doi.org/10.1155/2019/4842150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399552PMC
February 2019

Skull Base Mucormycosis in an Immunocompetent Patient: A Case Report and Literature Review.

Indian J Otolaryngol Head Neck Surg 2019 Mar 20;71(1):140-143. Epub 2018 Jun 20.

Department of ENT, Care Hospitals, Banjara Hills, Hyderabad, Telangana 500034 India.

To demonstrate the affection of skull base by mucormycosis in an immunocompetent individual. Mucormycosis is an opportunistic infection principally seen in immunocompromised individuals, but recently being increasingly recognized in otherwise healthy individuals. Skull base involvement secondary to otogenic nidus, mimicking otitis media was rarely reported. Read More

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http://dx.doi.org/10.1007/s12070-018-1428-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401032PMC

Global Epidemiology of Mucormycosis.

J Fungi (Basel) 2019 Mar 21;5(1). Epub 2019 Mar 21.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

Mucormycosis is an angio-invasive fungal infection, associated with high morbidity and mortality. A change in the epidemiology of mucormycosis has been observed in recent years with the rise in incidence, new causative agents and susceptible population. The rise has been perceived globally, but it is very high in the Asian continent. Read More

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http://dx.doi.org/10.3390/jof5010026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462913PMC
March 2019
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Mucormycosis in Burn Patients.

J Fungi (Basel) 2019 Mar 21;5(1). Epub 2019 Mar 21.

CHU Lille, Laboratoire de Parasitologie-Mycologie, F-59000 Lille, France.

Patients with extensive burns are an important group at risk for cutaneous mucormycosis. This study aimed to perform a systematic review of all reported mucormycosis cases in burn patients from 1990 onward. A Medline search yielded identification of 7 case series, 3 outbreaks, and 25 individual cases reports. Read More

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http://dx.doi.org/10.3390/jof5010025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463177PMC

A population-based analysis of invasive fungal disease in haematology-oncology patients using data linkage of state-wide registries and administrative databases: 2005 - 2016.

BMC Infect Dis 2019 Mar 21;19(1):274. Epub 2019 Mar 21.

Department of Infectious Diseases, Alfred Health and Central Clinical School, Monash University, Melbourne, Victoria, Australia.

Background: Little is known about the morbidity and mortality of invasive fungal disease (IFD) at a population level. The aim of this study was to determine the incidence, trends and outcomes of IFD in all haematology-oncology patients by linking Victorian hospital data to state-based registries.

Methods: Episodes of IFD complicating adult haematological malignancy (HM) and haematopoietic stem cell transplantation (HSCT) patients admitted to Victorian hospitals from 1 July 2005 to 30 June 2016 were extracted from the Victorian Admitted Episodes Dataset and linked to the date of HM diagnosis from the Victorian Cancer Registry and mortality from the Victorian Death Index. Read More

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http://dx.doi.org/10.1186/s12879-019-3901-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429824PMC
March 2019
3 Reads

Molecular Strategies to Diagnose Mucormycosis.

J Fungi (Basel) 2019 Mar 20;5(1). Epub 2019 Mar 20.

Parasitology Mycology Department, University Hospital, 25000 Besancon, France.

Molecular techniques have provided a new understanding of the epidemiology of mucormycosis and improved the diagnosis and therapeutic management of this life-threatening disease. PCR amplification and sequencing were first applied to better identify isolates that were grown from cultures of biopsies or bronchalveolar lavage samples that were collected in patients with Mucorales infection. Subsequently, molecular techniques were used to identify the fungus directly from the infected tissues or from bronchalveolar lavage, and they helped to accurately identify Mucorales fungi in tissue samples when the cultures were negative. Read More

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http://dx.doi.org/10.3390/jof5010024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463105PMC
March 2019
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Activity of Combinations of Zinc Chelators with Amphotericin B and Posaconazole Against Six Mucorales Species.

Antimicrob Agents Chemother 2019 Mar 18. Epub 2019 Mar 18.

Laboratorio de Micología y Diagnóstico Molecular - Cátedra de Parasitología y Micología - Facultad de Bioquímica y Ciencias Biológicas - Universidad Nacional del Litoral. Santa Fe (Argentina).

Mucormycosis is an emerging disease with high mortality rates. Few antifungal drugs are active against Mucorales. Considering the low efficacy of monotherapy, combination-therapy strategies have been described. Read More

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http://dx.doi.org/10.1128/AAC.00266-19DOI Listing

Severe Gastric Mycormycosis Infection Followed by Cytomegalovirus Pneumonia in a Renal Transplant Recipient: A Case Report and Concise Review of the Literature.

Transplant Proc 2019 Mar 3;51(2):556-560. Epub 2019 Jan 3.

Department of Transplantation & General Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. Electronic address:

Mucormycosis is an uncommonly encountered fungal infection in solid-organ transplantation, occurring most often gastrointestinally. The most common and fatal infectious disease is cytomegalovirus (CMV) pneumonia, which may result in acute respiratory distress syndrome (ARDS), with rapid onset. Early diagnosis, active treatment, and rational reduction of immunosuppressants are crucial for successful kidney transplantation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183162
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http://dx.doi.org/10.1016/j.transproceed.2018.12.023DOI Listing
March 2019
4 Reads

Fatal renal mucormycosis with Apophysomyces elegans in an apparently healthy male.

Aging Male 2019 Mar 16:1-4. Epub 2019 Mar 16.

a Department of Laboratory Medicine and Pathology , Hamad General Hospital , Doha , Qatar.

Mucor is an angioinvasive fungus that was reported mainly in immunocompromised patients. It usually presents as rhino-orbital, pulmonary, gastrointestinal, and disseminated disease. Isolated renal mucormycosis is an extremely rare infection in immunocompetent patients and is associated with high fatality rate. Read More

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http://dx.doi.org/10.1080/13685538.2019.1586871DOI Listing
March 2019
2 Reads

Successful Mandibular Mucormycosis Treatment in the Severely Neutropenic Patient.

J Oral Maxillofac Surg 2019 Feb 18. Epub 2019 Feb 18.

Head, Department of Oral and Maxillofacial Surgery, Hebrew University-Hadassah, Jerusalem, Israel.

Purpose: Mucormycosis is a rare opportunistic and aggressive deep fungal infection that predominantly affects immunocompromised patients, and its mortality rate has been reported as up to 80%. Typing of the infection is based mainly on clinical and anatomic presentations, with the most common being the rhinocerebral type.

Materials And Methods: This report presents 3 patients with cancer who had successful treatment of mandibular mucormycosis. Read More

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http://dx.doi.org/10.1016/j.joms.2019.02.012DOI Listing
February 2019
2 Reads

Disease Entities in Mucormycosis.

J Fungi (Basel) 2019 Mar 14;5(1). Epub 2019 Mar 14.

Université Paris Descartes, Centre d'Infectiologie Necker Pasteur, IHU Imagine, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), 75015 Paris, France.

Mucormycosis is an emerging life-threatening fungal infection caused by . This infection occurs mainly in immunocompromised patients, especially with hematological malignancy, transplantation, or diabetes mellitus. Rhino-orbito-cerebral and pulmonary mucormycosis are the predominant forms. Read More

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http://dx.doi.org/10.3390/jof5010023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462957PMC

Cutaneous Mucormycosis in Solid Organ Transplant Recipients after Hurricane Harvey: Short- and Long-term Management.

Plast Reconstr Surg Glob Open 2019 Jan 15;7(1):e2041. Epub 2019 Jan 15.

Department of Surgery, Division of Abdominal Transplantation, Baylor College of Medicine.

In the fall of 2017, Hurricane Harvey, one of the most costly hurricanes in American history, ravaged the Texas Gulf Coast, interrupting basic sanitation systems to hundreds of thousands of Texas residents. In the aftermath of Hurricane Harvey, our Houston hospitals noted an uptick in the incidence of cases of mucormycosis. Among the most vulnerable and affected have been immunocompromised transplant recipients. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382219PMC
January 2019
2 Reads

Real-world use-Isavuconazole at a large academic medical center.

Mycoses 2019 Mar 9. Epub 2019 Mar 9.

Department of Infectious Disease, Cleveland Clinic, Cleveland, Ohio.

Background: Isavuconazole use in the real-world setting has not been extensively described. Subgroups of patients with particular prognostic significance, such as previous triazole prophylaxis or treatment and the important subgroup treated empirically for invasive fungal infection, have beforehand been excluded from trials.

Objectives: We aimed to determine treatment response and safety in these patients at a large US transplant and cancer centre. Read More

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http://dx.doi.org/10.1111/myc.12910DOI Listing

Antifungal combinations in Mucorales: a microbiological perspective.

Mycoses 2019 Mar 4. Epub 2019 Mar 4.

Université Paris Descartes, Faculté de Médecine, AP-HP, Hôpital Européen Georges Pompidou, Unité de Parasitologie-Mycologie, F-75015, Paris, France.

Mucormycosis mostly affects immunocompromised patients and is associated with a high morbidity and mortality despite currently available treatments. In that context, combination therapy might be the key to a better outcome for these patients. Purpose of this review is to summarize and discuss the current combination data obtained in vitro, in vivo in animal models of mucormycosis, and in patients. Read More

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http://dx.doi.org/10.1111/myc.12909DOI Listing
March 2019
2 Reads

Comparison of genotyping methods for Cunninghamella bertholletiae.

Mycoses 2019 Mar 2. Epub 2019 Mar 2.

Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Background: Invasive fungal infections caused by filamentous fungi of the order Mucorales are serious complications in immunocompromised patients and often associated with fatal outcome. As a member of this order, Cunninghamella bertholletiae is a saprophytic fungus with naturally exhibited high minimum inhibitory concentrations against common antifungal drugs and with the potential for outbreaks in clinical settings.

Objectives And Methods: In a proof-of-principle study, we evaluated the performance of microsatellite markers for the discrimination of thirteen C. Read More

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http://dx.doi.org/10.1111/myc.12908DOI Listing

Orbital apex syndrome caused by Alternaria species: A novel invasive fungus and new treatment paradigm.

Orbit 2019 Mar 1:1-4. Epub 2019 Mar 1.

a Vanderbilt University Medical Center , Nashville , TN , USA.

Orbital apex syndrome as a result of invasive fungal sinusitis is a disease entity most commonly found in immunocompromised patients. Infectious invasion affecting the orbital apex can have devastating visual and life-threatening consequences. Mucormycosis and Aspergillus species are the most common causes of such infections. Read More

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http://dx.doi.org/10.1080/01676830.2019.1582071DOI Listing
March 2019
1 Read

Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors.

Med Mycol 2019 Apr;57(Supplement_2):S245-S256

Jena Microbial Resource Collection, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Adolf-Reichwein-Strasse 23, 07745 Jena, Germany.

Fungi of the basal lineage order Mucorales are able to cause infections in animals and humans. Mucormycosis is a well-known, life-threatening disease especially in patients with a compromised immune system. The rate of mortality and morbidity caused by mucormycosis has increased rapidly during the last decades, especially in developing countries. Read More

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http://dx.doi.org/10.1093/mmy/myz011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394756PMC
April 2019
3 Reads

Contrasts between mucormycosis and aspergillosis in oncohematological patients.

Med Mycol 2019 Apr;57(Supplement_2):S138-S144

I.P.Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo str., Saint Petersburg, Russian Federation, 197022.

In retrospective multicenter study from years 2007-2017, we evaluated 59 oncohematological patients with mucormycosis and 541 with invasive aspergillosis (IA). Mucormycosis developed more often in children and adolescents (P = .001), as well as after the emergence of graft versus host disease (P = . Read More

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http://dx.doi.org/10.1093/mmy/myy116DOI Listing
April 2019
6 Reads

Broad spectrum triazoles for invasive mould infections in adults: Which drug and when?

Med Mycol 2019 Apr;57(Supplement_2):S168-S178

Division of Infectious Diseases, Department of Medicine, University of California-San Diego, San Diego, California, USA.

Invasive mould infections are an increasing cause of morbidity and mortality globally, mainly due to increasing numbers of immunocompromised individuals at risk for fungal infections. The introduction of broad spectrum triazoles, which are much better tolerated compared to conventional amphotericin B formulations, has increased survival, particularly in invasive mould infection. However, early initiation of appropriate antifungal treatment remains a major predictor of outcome in invasive mould infection, but despite significant advances in diagnosis of these diseases, early diagnosis remains a challenge. Read More

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http://dx.doi.org/10.1093/mmy/myy052DOI Listing
April 2019
3 Reads

An unusual cause of massive upper gastrointestinal bleeding-gastric mucormycosis.

Oxf Med Case Reports 2019 Feb 16;2019(2):omy135. Epub 2019 Feb 16.

Division of Gastroenterology, Montefiore Medical Center, Wakefield Campus, Bronx, NY, USA.

Mucormycosis of the gastrointestinal tract is a life threatening infection most commonly seen in patients with severe immunosuppression. A 42-year-old male with history of choriocarcinoma was admitted to the intensive care unit with septic shock. He developed massive hematemesis requiring upper endoscopy which showed multiple deep gastric ulcers. Read More

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http://dx.doi.org/10.1093/omcr/omy135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380533PMC
February 2019

Severe facial necrosis in a type 1 diabetic patient secondary to mucormycosis masquerading as an internal maxillary artery occlusion: a case report.

BMC Infect Dis 2019 Feb 22;19(1):184. Epub 2019 Feb 22.

Alberta Health Services, Calgary, Canada.

Background: Mucormycosis is a group of rare but life threatening angioinvasive infections caused by fungi of the order Mucorales that often occurs in immunocompromised patients and individuals with poorly controlled diabetes. Rhinocerebral mucormycosis can mimic sinusitis but can rapidly progress to deeper disease and cause facial necrosis. Facial vascular thrombosis is a rare complication of mucormycosis and can confound diagnosis of the disease. Read More

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http://dx.doi.org/10.1186/s12879-019-3822-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387511PMC
February 2019
3 Reads

Evaluation of mass spectrometry detection of pan-fungal serum disaccharide (MS-DS) for the diagnosis of invasive fungal infections: results from a collaborative study involving six European clinical centres.

J Clin Microbiol 2019 Feb 20. Epub 2019 Feb 20.

Laboratoire de Parasitologie Mycologie, CHU Lille, Univ. Lille, Inserm U995 - LIRIC - Lille Inflammation Research International Centre, F-59000 Lille, France

A mass spectrometry (MS) method that detects a serum disaccharide (MS-DS) was recently described for the diagnosis of invasive fungal infections (IFI). We carried out a European collaborative study to evaluate this assay. Patients with IFI were selected according to the availability of sera obtained around the time that IFI was documented: invasive candidiasis (IC; n=26 patients), invasive aspergillosis (IA; n=19), mucormycosis (MM; n=23). Read More

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http://dx.doi.org/10.1128/JCM.01867-18DOI Listing
February 2019
3.993 Impact Factor

Development and validation of the European QUALity (EQUAL) score for mucormycosis management in haematology.

J Antimicrob Chemother 2019 Feb 15. Epub 2019 Feb 15.

Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne, Cologne, Germany.

Background: Mucormycosis is a life-threatening infection in immunocompromised patients and in haematological malignancy patients in particular.

Objectives: Our aim was to develop and evaluate a scoring tool to measure adherence to current guidelines for mucormycosis.

Methods: Current guidelines of scientific societies on mucormycosis management were reviewed. Read More

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http://dx.doi.org/10.1093/jac/dkz051DOI Listing
February 2019
2 Reads
5.313 Impact Factor

Epidemiology and clinical outcomes of invasive mould infections in Indian intensive care units (FISF study).

J Crit Care 2019 Feb 5;51:64-70. Epub 2019 Feb 5.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background And Aim: Due to limited data on invasive mould infections (IMIs) in the intensive care units (ICUs) of developing countries, we ascertain epidemiology and management of IMIs at 11 ICUs across India.

Methods: Consecutive patients with proven or probable/putative IMIs were enrolled during the study period. Subjects were categorized into classical (neutropenia, malignancy, transplant recipients on immunosuppression) and non-classical (chronic obstructive pulmonary disease, diabetes, liver disease and glucocorticoids) risk groups. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.005DOI Listing
February 2019
10 Reads

Pulmonary Mucormycosis in a Patient With Uncontrolled Diabetes.

Fed Pract 2018 Jan;35(1):32-36

and are Internal Medicine Residents at Scott and White Memorial Hospital. and are Physicians at the Central Texas Veterans Health Care System; all in Temple, Texas.

Prompt diagnosis of a patient presenting with rhinocerebral, pulmonary, gastrointestinal, and central nervous system manifestations is critical for treatment of this potentially fatal fungal infection. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248142PMC
January 2018
6 Reads

Invasive sino-orbital fungal infections in immunocompetent patients: a clinico-pathological study.

Eye (Lond) 2019 Feb 14. Epub 2019 Feb 14.

Department of Orbit, Oculoplasty & Ocular Oncology, Aravind Eye Hospital, Madurai, India.

Objective: Invasive sino-orbital fungal infections in immunocompetent patients are a rare clinical entity; the diagnosis and management of which is challenging. We present a large case series of invasive sino-orbital fungal granulomas in patients without pre-existing systemic immunocomprimising condition.

Design: Retrospective case series. Read More

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http://dx.doi.org/10.1038/s41433-019-0358-6DOI Listing
February 2019
1 Read

An Unusual Case of Large-Vessel Vasculitis.

Eur J Case Rep Intern Med 2018 26;5(7):000897. Epub 2018 Jul 26.

Department of Medicine (Rheumatology), Hamad Medical Corporation, Doha, Qatar.

We report the case of a previously healthy 35-year-old man who presented with severe abdominal pain, nausea, vomiting and subjective fever and was found to have acute kidney injury, haematuria, leukocytosis and elevated inflammatory markers. An abdominal CT scan showed lobar nephronia of the left kidney complicated by infarction. Subsequent MRI also revealed splenic infarction. Read More

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http://dx.doi.org/10.12890/2018_000897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346781PMC
July 2018
2 Reads