Search Our Scientific Publications & Authors

J Pain Symptom Manage 2022 Jun 22. Epub 2022 Jun 22.

International Observatory on End of Life Care, Division of Health Research, Lancaster University, Lancaster, UK.

Context: Evidence of symptom control outcomes in severe COVID is scant.

Objective: To determine changes in symptoms among people severely ill or dying with COVID supported by palliative care, and associations with treatments and survival.

Methods: Multicentre cohort study of people with COVID across England and Wales supported by palliative care services, during the pandemic in 2020 and 2021. Read More

Orthod Craniofac Res 2022 Jun 25. Epub 2022 Jun 25.

Department of orthodontics, Faculty of Dentistry, First affiliated hospital of Zhengzhou University, Henan, China.

Objective: This randomized controlled trial (RCT) aims to investigate the short-term effects of chlorhexidine mouthwash (MW) on gingival health surrounding orthodontic miniscrew implants (OMIs) and their overall survivability.

Materials And Methods: Thirty-two participants (mean age, 22.8 years) undergoing fixed orthodontic appliance treatment after maxillary premolar extraction were randomly allocated in a parallel fashion to either receive (1) MW with an active component of chlorhexidine, or (2) a placebo. Read More

Dig Endosc 2022 Jun 25. Epub 2022 Jun 25.

Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.

Background: The COVID-19 pandemic has raised concerns on whether colonoscopies (CS) carry a transmission risk. The aim was to determine whether colonoscopies are an aerosol-generating procedures.

Methods: This was a prospective observational trial including all patients undergoing CS in Prince of Wales Hospital from 1st June to 31st July 2020. Read More

Int J Cancer 2022 Jun 24. Epub 2022 Jun 24.

Department of Pathology, NYU School of Medicine, New York, New York, USA.

The incidence of esophageal adenocarcinoma (EA) has drastically increased in the United States since 1970s for unclear reasons. We hypothesized that the widespread usage of antibiotics has increased the procarcinogenic potential of the orodigestive microbiota along the sequence of gastroesophageal reflux (GR), Barrett's esophagus (BE), and EA phenotypes. This case control study included normal controls (NC) and three disease phenotypes GR, BE, and EA. Read More

Evid Based Dent 2022 Jun 24;23(2):81-83. Epub 2022 Jun 24.

College of Dental Medicine, Kaohsiung Medical University; Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Aim This study aimed to compare the long-term outcome of implant therapy in partially edentulous patients with severe periodontitis compared to those with no history of periodontitis.Design Retrospective cohort study.Cohort selection Eighty-eight patients (34 men and 54 women; age ranging from 28 to 45 years) with severe periodontitis (47 patients with 108 implants) and no history of periodontitis (41 patients with 78 implants) were included in this institutional study. Read More

Evid Based Dent 2022 Jun 24;23(2):60-61. Epub 2022 Jun 24.

Department of Periodontics and Oral Implantology, DAV (C) Dental College Yamunanagar, Haryana, India.

Data sources Four electronic databases, including Cochrane Oral Health's Trial Register, Cochrane CENTRAL, Medline and Embase were searched for finding the relevant literature. Two trial registries and references of the included papers were also searched.Study selection Both parallel-group and split-mouth randomised control trials were included. Read More

Sci Rep 2022 Jun 24;12(1):10722. Epub 2022 Jun 24.

Department of Otorhinolaryngology, Habib Bourguiba Hospital, Sfax, Tunisia.

To establish easily measurable and reproducible preoperative parameters predicting difficult laryngeal exposure in direct laryngoscopy. A prospective study including 71 patients who underwent transoral microsurgery for benign or malignant lesions of the larynx was performed in our department from January 2021 to November 2021. Physical assessment included the Mallampati score, weight, height, body mass index and measurements of seven parameters in the cervical region. Read More

Br J Oral Maxillofac Surg 2021 Jul 22. Epub 2021 Jul 22.

(Bio)medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea; Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University, Yangsan, Republic of Korea; Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea. Electronic address:

In this study, we aimed to examine the effectiveness of self-irrigation following the extraction of mandibular third molars. A randomised controlled clinical trial was conducted with 155 patients who had undergone extraction of a mandibular third molar. The irrigation group was instructed to self-irrigate the extraction socket with tap water using a syringe three times a day, starting seven days after the tooth extraction. Read More

Otolaryngol Clin North Am 2022 Jun 21. Epub 2022 Jun 21.

Private Practice; Department of Otolaryngology-Head and Neck Surgery, University of Texas Medical Branch, Galveston, TX, USA. Electronic address:

The perioral area can be an important feature to convey femininity, particularly when speaking and smiling. A feminine lip has a shorter distance between the nasal sill and the vermillion border, fullness of the vermillion, and a few millimeters of tooth show with the mouth slightly open. The keys to a good outcome are incision design that respects the natural anatomy, placing the tension of the lift deep to the dermis to take tension off of the skin incision, determining the appropriate amount of lift for the patient's anatomy, and not violating the orbicularis oris. Read More

Microb Pathog 2022 Jun 21:105651. Epub 2022 Jun 21.

Key Laboratory of Mariculture & Stock Enhancement in North China's Sea, Ministry of Agriculture and Rural Affairs, Dalian Ocean University, Dalian, Liaoning, 116023, PR China; College of Life Science, Liaoning Normal University, Dalian, Liaoning, 116029, PR China. Electronic address:

The sea urchin Strongylocentrotus intermedius, famous for its gonadal quality, is one of the most important farmed species in the sea area of northern China. Since 2020, outbreaks of black peristomial membrane disease (commonly called black mouth disease) have frequently occurred in spring and winter in cultured S. intermedius. Read More

Oral Oncol 2022 Jun 21;132:105978. Epub 2022 Jun 21.

Department of Otorhinolaryngology, Head and Neck Surgery, RWTH University of Aachen, Germany. Electronic address:

Introduction: Confocal laser endomicroscopy (CLE) is an optical imaging technique that allows in vivo microscope-like images of the upper aerodigestive tract's mucosa in 1000-fold magnification. The assessment of morphological tissue characteristics for the correct differentiation between healthy and malignoma suspected mucosa requires strict evaluation criteria. This study aims to validate a score for oral cavity squamous cell carcinoma (OCSCC) diagnostic. Read More

Drug Dev Res 2022 Jun 24. Epub 2022 Jun 24.

Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.

Dry mouth is the main manifestation of Sjögren syndrome (SS). Quercetin has been reported to alleviate radiation-induced salivary gland damage, yet the effect of quercetin on SS-caused salivary gland damage remains unclear. This study aimed to investigate the effects of quercetin on SS-induced salivary gland damage and the mechanism underlying its therapeutic potential in SS. Read More

J Contemp Dent Pract 2022 Feb 1;23(2):215-220. Epub 2022 Feb 1.

Consultant Prosthodontist, Ghaziabad, Uttar Pradesh, India.

Aim: The study aimed to evaluate the compressive strength and surface hardness of a type V dental stone after hypochlorite disinfection.

Materials And Methods: Two types of specimens were made according to the American Dental Association (ADA) specification no. 25 for each wet compressive strength, dry compressive strength, and surface hardness. Read More

J Contemp Dent Pract 2022 Feb 1;23(2):208-214. Epub 2022 Feb 1.

Department of Pediatric and Preventive Dentistry, Government Dental College and Hospital, Nagpur, Maharashtra, India.

Aim: The aim of this study was to evaluate clinical and radiographical success of ozonoid olive oil as an indirect pulp capping (IPC) agent in primary mandibular second molar when compared to calcium hydroxide and to evaluate the antimicrobial efficacy of ozonoid olive oil on and .

Materials And Methods: A split-mouth randomized controlled trial was conducted on 30 primary mandibular second molars in 15 children of age 5-9 years with deep dentinal carious lesion. Teeth were randomly allocated to two groups of 15 each. Read More

J Contemp Dent Pract 2022 Feb 1;23(2):193-201. Epub 2022 Feb 1.

Department of Orthodontics and Dentofacial Orthopaedics, Vaidin Dental College and Research Center, Daman, India.

Aim: A major limitation of indirect bonding is incomplete penetration of the curing light through transfer trays, leading to inadequate curing of light-cure adhesive resin, causing bracket bond failure. Dual-cure adhesive resin is both light and chemically cured, which reduces the requirement of light for curing of the composite. Comparative evaluation of bracket failure rate and bond strength between dual-cure composite and light-cure composite for indirect orthodontic bonding of brackets. Read More

J Contemp Dent Pract 2022 Feb 1;23(2):162-168. Epub 2022 Feb 1.

Department of Prosthodontics, AB Shetty Memorial Institute of Dental Sciences, Mangaluru, Karnataka, India.

Background: Dental implants have become a popular alternative in the oral and maxillofacial rehabilitation after the introduction of the concept of osseointegration. A poor density bone can negatively influence the bone to implant contact (BIC) and delay osseointegration. Various osteotomy techniques and drilling procedures have been used to increase stability in low-density bone. Read More

Curr Pharm Des 2022 Jun 23. Epub 2022 Jun 23.

Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda, 151001, Punjab, India.

Background The presentation of 3D printing in drug innovation especially focuses on the advancement of patient-centered dosage forms based on structural design. Rising interest for customizations 3D printed inserts during surgeries combined with developing R&D speculations is driving the medical services.

Introduction: 3D printing technique is considered emerging digitized technology and it is beneficial for future progression and development of customized dosage forms, prostheses, implantable medical devices, tissue making, disease modeling, and many more. Read More

Arthrosc Sports Med Rehabil 2022 Jun 30;4(3):e1185-e1191. Epub 2022 May 30.

University of Miami Sports Medicine Institute, Coral Gables, Florida, U.S.A.

Purpose: To (1) identify the percentage of patients seen in an orthopaedic sports medicine practice who use social media and (2) identify the role that social media has in physician selection as compared with other factors.

Methods: After institutional review board approval was received, new patients aged 18 years or older who attended a single orthopaedic sports medicine office from February 2020 to May 2021 were identified for inclusion. Sociodemographic information was recorded, and each patient was asked to fill out a questionnaire that assessed social media usage and online resources used to choose and formulate opinions regarding the patient's provider. Read More

Front Oral Health 2022 7;3:940177. Epub 2022 Jun 7.

Department of Preventive and Public Health Dentistry, Faculty of Dentistry, University of Indonesia, Depok, Indonesia.

EClinicalMedicine 2022 Jul 8;49:101487. Epub 2022 Jun 8.

Department of Disease Control, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

Background: The eye-seeking fly can act as a vector for ocular , causing trachoma, yet there has been very little research on control measures. We investigated whether insect repellent products, specifically insecticide-treated clothing, could provide personal protection to the user from eye-seeking flies.

Methods: We first conducted a series of phase I laboratory studies to inform our choice of field intervention. Read More

Viruses 2022 May 28;14(6). Epub 2022 May 28.

Department of Biopharmacy, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Influenza virus infects the host and transmits through the respiratory tract (i.e., the mouth and nose); therefore, the development of intranasal influenza vaccines that mimic the natural infection, coupled with an efficient mucosal adjuvant, is an attractive alternative to current parenteral vaccines. Read More

Viruses 2022 May 27;14(6). Epub 2022 May 27.

The Pirbright Institute, Ash Road, Woking GU24 0NF, UK.

Foot-and-mouth disease is an economically devastating disease of livestock caused by foot-and-mouth disease virus (FMDV). Vaccination is the most effective control measure in place to limit the spread of the disease; however, the success of vaccination campaigns is hampered by the antigenic diversity of FMDV and the rapid rate at which new strains emerge that escape pre-existing immunity. FMDV has seven distinct serotypes, and within each serotype are multiple strains that often induce little cross-protective immunity. Read More

Viruses 2022 May 25;14(6). Epub 2022 May 25.

National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

Enterovirus infections can cause hand, foot, and mouth disease (HFDM), aseptic meningitis, encephalitis, myocarditis, and acute flaccid myelitis, leading to death of infants and young children. However, no specific antiviral drug is currently available for the treatment of this type of infection. The Unites States and United Kingdom health authorities recently approved a new antiviral drug, molnupiravir, for the treatment of COVID-19. Read More

Vaccines (Basel) 2022 Jun 2;10(6). Epub 2022 Jun 2.

Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China.

Background: The aim of this study was to investigate the immunogenicity and safety of the enterovirus 71 vaccine (EV71 vaccine) administered alone or simultaneously.

Methods: A multi-center, open-label, randomized controlled trial was performed involving 1080 healthy infants aged 6 months or 8 months from Shandong, Shanxi, Shaanxi, and Hunan provinces. These infants were divided into four simultaneous administration groups and EV71 vaccine separate administration group. Read More

Sensors (Basel) 2022 Jun 7;22(12). Epub 2022 Jun 7.

Computer Science Department, California State University, Northridge (CSUN), Northridge, CA 91330, USA.

Sensor technology that captures information from a user's neck region can enable a range of new possibilities, including less intrusive mobile software interfaces. In this work, we investigate the feasibility of using a single inexpensive flex sensor mounted at the neck to capture information about head gestures, about mouth movements, and about the presence of audible speech. Different sensor sizes and various sensor positions on the neck are experimentally evaluated. Read More

Pharmaceuticals (Basel) 2022 Jun 3;15(6). Epub 2022 Jun 3.

Department of Biomedical Engineering, University of Massachusetts, Lowell, MA 01854, USA.

Effective pulmonary drug delivery using a metered-dose inhaler (MDI) requires a match between the MDI sprays, the patient's breathing, and respiratory physiology. Different inhalers generate aerosols with distinct aerosol sizes and speeds, which require specific breathing coordination to achieve optimized delivery efficiency. Inability to perform the instructed breathing maneuver is one of the frequently reported issues during MDI applications; however, their effects on MDI dosimetry are unclear. Read More

Pathogens 2022 Jun 7;11(6). Epub 2022 Jun 7.

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a viral infection involving multi-organ manifestations. The main oral symptoms of COVID-19 associated are taste loss and xerostomia, but literature has reported other oral manifestation, such as oral blisters, ulcers, vesicles and other immunological lesions. This case report showed an Erythema Multiforme (EM) manifesting as oral mucosa lesions in a patient with a late diagnosis of COVID-19 infection. Read More

Pathogens 2022 Jun 3;11(6). Epub 2022 Jun 3.

Foreign Animal Disease Research Unit, Plum Island Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Greenport, NY 11957, USA.

Viral recombination contributes to the emergence of novel strains with the potential for altered host range, transmissibility, virulence, and immune evasion. For foot-and-mouth disease virus (FMDV), cell culture experiments and phylogenetic analyses of field samples have demonstrated the occurrence of recombination. However, the frequency of recombination and associated virus-host interactions within an infected host have not been determined. Read More

Life (Basel) 2022 Jun 20;12(6). Epub 2022 Jun 20.

Department of Oral and Maxillo Facial Sciences, Sapienza University of Rome, 00161 Rome, Italy.

This study aimed to compare the C-reactive protein level and visual analog scale scores of piezo- and rotatory-based surgical extraction of the third molar. As a split-mouth study, the comparative groups consisted of 25 patients, each of whom underwent surgical removal of the third molar by piezo on one side and rotatory bur on the other side. C-reactive protein levels were quantitatively assessed (enzyme-linked immunosorbent assay) before and immediately post-extraction. Read More

J Pers Med 2022 Jun 4;12(6). Epub 2022 Jun 4.

National Dental Centre Singapore, National Dental Research Institute Singapore, 5 Second Hospital Avenue, Singapore 168938, Singapore.

Periodontal disease is a major public health problem. This study aimed to develop a nomogram using a self-reported periodontitis screening instrument in predicting severe periodontitis (SP), defined by the World Workshop on Classification of Periodontal and Peri-Implant Diseases and Conditions, and evaluate its utility in clinical setting. An Akaike information criterion selected multivariable model was developed to predict SP using a self-reported questionnaire, with a nomogram developed based on its regression coefficients. Read More