Search Our Scientific Publications & Authors

Med Princ Pract 2019 Jan 15. Epub 2019 Jan 15.

Objective: To conduct a meta-analysis of evidence from randomized controlled trails (RCTs) of different doses of Intravenous Immunoglobulin (IVIG) in children with severe hand, foot and mouth disease (HFMD) to provide the scientific basis for clinical practice.

Methods: A search of PubMed-Medline, CNKI, Wanfang, and VIP database (until 30 June 2017) was performed and Software RevMan5.3 was used to evaluate the effect of different doses of IVIG on HFMD in RCTs, We used random effects models (or fixed effects models) and generic inverse variance methods to process quantitative data, followed by a leave-one-out method for sensitivity analysis. Read More

Acta Parasitol 2019 Jan 15. Epub 2019 Jan 15.

Parasitology Research Laboratory, Department of Zoology, Burdwan University, Golapbag, Purba Bardhaman, West Bengal, 713104, India.

Aims: The purpose of this article is to describe a new species of Rhabdias Stiles and Hassall, 1905 from West Bengal, India. Rhabdias bengalensis sp. nov. Read More

JPEN J Parenter Enteral Nutr 2019 Jan 15. Epub 2019 Jan 15.

Department of Surgery, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.

Background: Dietary intake sharply impacts the structure and function of the gut microbiota, which is important for childhood health. However, little is known about the microbiota of children who cannot eat by mouth. Standard enteral formulas for supplemental nutrition are low in fiber and high in processed sugars and are commonly associated with gastrointestinal side effects. Read More

PeerJ 2019 9;6:e6177. Epub 2019 Jan 9.

Emergency Centre for Transboundary Animal Diseases (ECTAD), FAO Regional Office for Asia and the Pacific (FAO-RAP), Bangkok, Thailand.

The aim of this study is to understand the role that the movement patterns of pigs, cattle and buffalo play in the spread of foot-and-mouth disease (FMD). A cross-sectional survey consisting of a questionnaire was used in a hotspot area for FMD: Xayabouli Province, Lao People's Democratic Republic. A total of 189 respondents were interviewed. Read More

Sci Rep 2019 Jan 14;9(1):112. Epub 2019 Jan 14.

Department of Epidemiology and Population Health, Institute of Infection and Global Health, University of Liverpool, Leahurst Campus, Chester High Road, Neston, CH64 7TE, UK.

In 2006, bluetongue (BT), a disease of ruminants, was introduced into northern Europe for the first time and more than two thousand farms across five countries were affected. In 2007, BT affected more than 35,000 farms in France and Germany alone. By contrast, the UK outbreak beginning in 2007 was relatively small, with only 135 farms in southeast England affected. Read More

Vet Microbiol 2019 Feb 26;229:124-129. Epub 2018 Dec 26.

Center for Foot-and-Mouth Disease Vaccine Research, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon City, Gyeongsangbuk-do, 39660, Republic of Korea. Electronic address:

Foot-and-mouth disease (FMD) is an acute infectious disease occurring in cloven-hoofed animals. There are many variations of the virus, making it difficult to protect against the various strains with one virus vaccine. The immunogenicity has generally been evaluated in pigs using neutralizing antibodies to determine the protection level against foot-and-mouth disease virus type O. Read More

BMC Public Health 2019 Jan 14;19(1):63. Epub 2019 Jan 14.

Center for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, USA.

Background: In Myanmar, HIV is concentrated among key populations, yet less than half of the estimated 250,000 men who have sex with men (MSM) and transgender women (TW) report recent HIV testing. As many as 50% of MSM and TW may conceal their same-sex preferences and behaviors, yet little is known about the barriers faced by those who are locally regarded as 'hidden' - that is, MSM who do not disclose same-sex preferences and/or identify as gay. This study explored specific barriers to accessing HIV testing and other prevention services among 'hidden' MSM to inform appropriate models of service delivery. Read More

Materials (Basel) 2019 Jan 13;12(2). Epub 2019 Jan 13.

School of Chemical Engineering, Chonbuk National University, Jeonju 54896, Korea.

Detection of formaldehyde is very important in terms of life protection, as it can cause serious injury to eyes, skin, mouth and gastrointestinal function if indirectly inhaled. Researchers are therefore putting effort into developing novel and sensitive devices. In this work, we have fabricated an electro-chemical sensor in the form of a field effect transistor (FET) to detect formaldehyde over a wide range (10 nM to 1 mM). Read More

Viruses 2019 Jan 12;11(1). Epub 2019 Jan 12.

Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald, Germany.

Foot-and-mouth disease (FMD) is the most devastating disease of cloven-hoofed livestock, with a crippling economic burden in endemic areas and immense costs associated with outbreaks in free countries. Foot-and-mouth disease virus (FMDV), a picornavirus, will spread rapidly in naïve populations, reaching morbidity rates of up to 100% in cattle. Even after recovery, over 50% of cattle remain subclinically infected and infectious virus can be recovered from the nasopharynx. Read More

Zhongguo Zhong Xi Yi Jie He Za Zhi 2016 08;36(8):929-932

Objective To observe distribution laws and features of syndrome types of Chinese medicine (CM) in hyperlipidemia patients of Han, Uyghur, Kazakh nationalities in Xinjiang Uyghur Auton- omous Region. Methods Using cluster random sampling, 1 410 hyperlipidemia patients (18 -70 years old ) were recruited from Urumqi, Turpan, Altay, Ili, Aksu, Hetian in Xinjiang Uyghur Autonomous Re- gion. The general condition, susceptible factors, classification of blood lipids, complications, syndromes of CM, tongue figure, etc. Read More

Front Horm Res 2019 19;51:139-146. Epub 2018 Nov 19.

Parathyroid hormone (PTH) is one of the major hormones that regulates serum calcium. Hypoparathyroidism occurs when PTH secretion is insufficient. The main symptoms of hypoparathyroidism are the result of low blood calcium levels, hypocalcemia, which interferes with normal muscle contraction and nerve conduction. Read More

Mol Phylogenet Evol 2019 Jan 11. Epub 2019 Jan 11.

Key Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China; Laboratory of Plateau Fish Evolutionary and Functional Genomics, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China. Electronic address:

Highly specialized grade (HSG; genera Gymnocypris, Oxygymnocypris, Schizopygopsis, Platypharodon and Chuanchia) of the Schizothoracinae (Cypriniformes: Cyprinidae) are endemic to the Qinghai-Tibet Plateau (QTP). Previously, two distinct ecomorphs were recognized according to trophic traits. One was a limnetic omnivore with normal lower jaw morphology, terminal mouth, and moderate or dense gill rakers, mostly inhabiting in open water of lakes, including Gymnocypris and Oxygymnocypris. Read More

Acta Psychol (Amst) 2019 Jan 9;193:153-159. Epub 2019 Jan 9.

Swansea University, UK.

Two independent experiments (N = 30 and N = 24) investigated the effects of concurrent task loads on the recognition of faces displaying emotions. The study aimed to explore a possible resolution for an apparently discrepant finding in the literature regarding the impact of such loads on recognition of facial emotions. Faces displaying different emotions were presented, with or without a concurrent load, until the facial stimuli were correctly labelled to criterion in terms of the displayed emotion. Read More

Acad Pediatr 2019 Jan 10. Epub 2019 Jan 10.

Department of Health Care Policy, Harvard Medical School, Boston, MA; RAND Corporation, Boston, MA.

Objective: In commercial direct-to-consumer (DTC) telemedicine, physicians outside of the medical home treat common, acute complaints through real-time, audio-visual conferencing using telephones and personal computers. There has been little examination of the use of DTC telemedicine by children. We described trends in DTC telemedicine use and DTC telemedicine visit characteristics. Read More

Int J Infect Dis 2019 Jan 10. Epub 2019 Jan 10.

Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok-noi, Bangkok 10700, Thailand; Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, 999 Phuttamonthon 4 Road, Salaya, Nakhon Pathom 73170, Thailand. Electronic address:

Background: Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are the major causative agents of hand, foot and mouth disease (HFMD) worldwide, particularly in the Asia-Pacific region. Several strains emerged, circulated and faded out over time in recent decades. This study investigated the EV-A71 and CV-A16 circulating strains and replacement of genotypes/subgenotypes in Thailand during 2000-2017. Read More

Arch Phys Med Rehabil 2019 Jan 9. Epub 2019 Jan 9.

Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, Maryland; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Objectives: To investigate behavioral and demographic features of levels of consciousness in young children with brain injury, including classifications of conscious (CS), minimally conscious (MCS), and vegetative states (VS), and to investigate the course of recovery in children with disorders of consciousness (DOC).

Design: Retrospective chart review and post-hoc analysis.

Setting: Pediatric inpatient rehabilitation unit. Read More

J Acad Nutr Diet 2019 Jan 10. Epub 2019 Jan 10.

Background: Low fruit and vegetable intakes are recognized risk factors for noncommunicable diseases. This systematic review summarizes published meta-analyses of global burden of diseases attributable to low fruit and vegetable intakes, and the best relative risk estimates.

Methods: A published novel assessment process combining Cochrane Review measures, Assessing the Methodological Quality of Systematic Reviews checklist, and Newcastle-Ottawa Quality Assessment Scale was employed. Read More

Arch Pediatr 2019 Jan 10. Epub 2019 Jan 10.

Service des urgences pédiatriques, hôpital Armand-Trousseau, AP-HP, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France; Inserm U1153, université Pierre-et-Marie-Curie, Paris VI, 75005 Paris, France.

Acute gingivostomatitis is relatively frequent in children; of viral origin, its diagnosis is usually straightforward. Acute gingivostomatitis is very painful and for many years, codeine, whose use was restricted in 2013, was widely employed in this context. The aim of this study was to ascertain the prevalence of acute stomatitis in pediatric emergency care, to evaluate the pain caused by stomatitis, and to determine the analgesic resources deployed both in the emergency department and at discharge, over the 5-year period preceding restriction of the use of codeine. Read More

Oral Oncol 2019 Jan 9. Epub 2019 Jan 9.

Pathology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.

Solitary fibrous tumor is an uncommon neoplasm with unpredictable clinical behavior. Malignant solitary fibrous tumor is a rare morphological variant with more aggressive behavior and higher rates of local recurrences and distant metastasis, exceeding rare in oral cavity; our case occurred in the floor of the mouth in the sublingual gland. Read More

J Craniomaxillofac Surg 2018 Nov 28. Epub 2018 Nov 28.

Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China. Electronic address:

Objective: To explore the application of modified resection compared with traditional segmental resection of the mandible for patients with anterior floor of the mouth and tongue squamous cell carcinoma (SCC) without infiltration of the mandible.

Subjects And Methods: This is a retrospective study including 36 eligible patients with anterior floor of the mouth SCC(9 patients received modified mandibulectomy, and 27 patients received segmental mandibulectomy).

Results: No patients in the modified mandibulectomy group developed recurrence in the floor of the mouth, and all of the patients survived. Read More

J Dent Anesth Pain Med 2018 Dec 28;18(6):339-347. Epub 2018 Dec 28.

Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.

Background: There are many techniques of inferior alveolar nerve block injection (IANBI); one among them is the computer-assisted intraosseous injection (CAIOI). Here we aim to evaluate the effectiveness of CAIOI with Quicksleeper® in mandibular third molar surgery.

Methods: This study is a clinical, single-blind, randomized, split-mouth, controlled trial including 25 patients (10 males and 15 females, mean age 21 years). Read More

J Korean Assoc Oral Maxillofac Surg 2018 Dec 28;44(6):282-288. Epub 2018 Dec 28.

Department of Oral and Maxillofacial Surgery, Samsung Medical Center, Seoul, Korea.

Objectives: The purpose of this study was to evaluate the neck node metastasis pattern and related clinical factors in oral cavity cancer patients.

Materials And Methods: In total, 76 patients (47 males, 29 females) with oral squamous cell carcinoma (OSCC) who had no previous malignancies and were not undergoing neoadjuvant concomitant chemoradiotherapy or radiotherapy were selected for analysis.

Results: Occult metastases were found in 8 of 52 patients with clinically negative nodes (cN0, 15. Read More

Cancer Manag Res 2019 24;11:117-130. Epub 2018 Dec 24.

Iberoamerican Cochrane Centre, Institute of Biomedical Research Sant Pau (IIB Sant Pau), Barcelona, Spain,

Purpose: This evidence mapping aims to describe and assess the quality of available evidence in systematic reviews (SRs) on treatments for oral cancer.

Materials And Methods: We followed the methodology of Global Evidence Mapping. Searches in MEDLINE, EMBASE, Epistemonikos and The Cochrane Library were conducted to identify SRs on treatments for oral cancer. Read More

BMC Anesthesiol 2019 Jan 12;19(1):12. Epub 2019 Jan 12.

Department of Anesthesiology, Aichi Gakuin University School of Dentistry, 2-11 Suemori-dori, Chikusaku, Nagoya, 464-8651, Japan.

Background: Airway Scope (AWS) with its plastic blade does not require a head-tilt or separate laryngoscopy to guide intubations. Therefore, we hypothesized that its use would reduce the intubation time (IT) and the frequency of airway complication events when compared with the use of Macintosh Laryngoscope (ML) for infants with cleft lip and palate (CLP).

Methods: The parents of all patients provided written consents; we enrolled 40 infants with CLP (ASA-PS 1). Read More

J Clin Periodontol 2019 Jan 13. Epub 2019 Jan 13.

Department of Prosthetic Dentistry, Gerodontology and Biomaterials, University Medicine Greifswald, Germany.

Aim: We aimed to investigate associations between malocclusions and periodontal disease by comparing it to that of smoking in subjects recruited from the population-based cross-sectional study "Study of Health in Pomerania".

Materials And Methods: Sagittal intermaxillary relationship, variables of malocclusion, and socio-demographic parameters of 1202 dentate subjects, 20 to 39 years of age, were selected. Probing depth (PD) and attachment loss (AL) were assessed at four sites by tooth in a half mouth design. Read More

World J Surg Oncol 2019 Jan 11;17(1):15. Epub 2019 Jan 11.

Department of Surgical Oncology, Malabar Cancer Centre, Thalassery, Kerala, 670 103, India.

Background: Oral cancer is very common in India. The reported 5-year survival of such patients is around 50% after treatment with surgery and radiotherapy, much lower than most of the developed countries.

Methods: A retrospective study of a prospective database of oral cancer patients undergoing surgery from June 2009 to June 2013 was conducted. Read More

Int J Environ Res Public Health 2019 Jan 9;16(2). Epub 2019 Jan 9.

Department of Public Health Surveillance & Advisory, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Binjiang District, Hangzhou 310051, China.

This study aims to learn the characteristics of morbidity and mortality of notifiable diseases reported in children aged 0⁻14 years in Zhejiang Province in 2008⁻2017. We collated data from the China Information System for Disease Control and Prevention in Zhejiang province between 1 January 2008 and 31 December 2017 of children aged 0⁻14 years. From 2008 to 2017, a total of 32 types and 1,994,740 cases of notifiable diseases were reported in children aged 0⁻14 years, including 266 deaths in Zhejiang Province. Read More

Infant Behav Dev 2019 Jan 8;54:80-84. Epub 2019 Jan 8.

Department of Communication Sciences and Disorders, Northeastern University, Boston, MA, United States. Electronic address:

We investigated whether attention to a talker's eyes in 12 month-old infants is related to their communication and social abilities. We measured infant attention to a talker's eyes and mouth with a Tobii eye-tracker and examined the correlation between attention to the talker's eyes and scores on the Adaptive Behavior Questionnaire from the Bayley Scales of Infant and Toddler Development (BSID-III). Results indicated a positive relationship between eye gaze and scores on the Social and Communication subscales of the BSID-III. Read More

Tissue Eng Part A 2019 Jan 11. Epub 2019 Jan 11.

Korea Institute of Radiological and Medical Sciences, 37995, Radiation Biomedical Research, Nowon-gu, Seoul, Korea (the Republic of) ;

Radiotherapy (RT) in patients with cancer can kill cancer cells but also damage normal cells or tissues. During the treatment of patients with head and neck cancer or thyroid cancer, hyposalivation is a representative chronic side effect of radio-damaged salivary glands (SGs). The major symptom of hyposalivation is mouth dryness, resulting in several subsequent long-term complications. Read More

Am J Rhinol Allergy 2019 Jan 11:1945892418824451. Epub 2019 Jan 11.

1 Department of Otolaryngology - Head & Neck Surgery, University of Virginia, Charlottesville, Virginia.

Background: The association between olfactory dysfunction (OD) and cognitive decline is becoming apparent in the emerging literature. However, the literature demonstrating a similar effect between gustatory dysfunction (GD) and cognition is not well established.

Objective: To determine whether OD and GD are independently associated with cognitive impairment. Read More

J Formos Med Assoc 2019 Jan 7. Epub 2019 Jan 7.

Department of Dentistry, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan. Electronic address:

Dislocation of the mandibular condyle is one of several consequences of facial trauma that can be anticipated. The condylar neck is inherently weak and likely to fracture at the time of impact before dislocating into the middle cranial fossa. A review of the literature revealed that most cases of dislocation of the mandibular condyle into the middle cranial fossa are treated by open reduction and internal fixation via an extraoral approach or are treated conservatively with closed reduction. Read More

Vaccine 2019 Jan 7. Epub 2019 Jan 7.

School of Social Development and Public Policy, Beijing Normal University, China. Electronic address:

A 16 week newborn vaccinated with bOPV 4 weeks after his first routine IPV vaccination. Nineteen days later, asymmetrical paralysis was developed on his legs, and it was diagnosed to be VAPP. Perianal abscess is suspected to be a risk factor based on some limited results of retrospective studies in China. Read More

FASEB J 2019 Jan 10:fj201801661RR. Epub 2019 Jan 10.

Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.

Chemosensory signaling in organs such as the mouth and gut contributes to the mechanisms that control metabolism. We investigated the chemosensory pathways that regulate secretion of the hunger hormone ghrelin in response to neurotransmitters, bitter and sweet tastants at the cellular level in the human gut mucosa, and the disturbances in this regulatory pathway induced by obesity. Obesity impaired ghrelin protein production and adrenalin-induced ghrelin secretion in fundic cells, which was counterbalanced by somatostatin. Read More

Huan Jing Ke Xue 2018 Dec;39(12):5375-5382

Chinese Academy of Agricultural Sciences, Beijing 100081, China.

Nonpoint source pollution has become a major factor influencing the water quality. Identifying the pathway of nitrogen (N) transport from the source to the watershed mouth is a critical step in taking measures to control this pollution. However, it is difficult to identify the pathway of N transport because the transport pathway varies among different watersheds depending on the difference in the terrain, hydrology, and land cover etc and changes over time. Read More

Huan Jing Ke Xue 2019 Feb;40(2):625-632

Key Laboratory of Submarine Geosciences and Prospecting Techniques, Ministry of Education, College of Marine Geosciences, Ocean University of China, Qingdao 266100, China.

Simultaneous sampling and observation were conducted at 16 stations in the Pearl River Estuary, and the temporal and spatial characteristics of the contents of six heavy metals (Cr, Cu, Zn, Pb, As, and Cd) were analyzed. The influencing factors of suspended particulate matter (SPM) were explored through the combined results of our statistical analyses. With the influence of discharge, temperature and particle size, the content of heavy metals in the dry season is higher than that in flood season. Read More

Aust Dent J 2019 Jan 9. Epub 2019 Jan 9.

College of Medicine and Dentistry, James Cook University.

Background: The usefulness of administrating adjunctive systemic antibiotics to expedite healing of periodontal tissues is a topic of interest given the lack of clear guidelines.

Aim: To compare clinical outcomes in patients given adjunctive azithromycin (AZ), adjunctive amoxicillin plus metronidazole (AMX+MTZ), or scaling and root planing (SRP) alone in the treatment of moderate-to-severe chronic periodontitis.

Methods: Thirty-eight patients were randomly assigned into: SRP alone; 500mg AMX plus 400 mg MTZ three times per day for seven days; or 500mg AZ for three days. Read More

Appl Microbiol Biotechnol 2019 Jan 9. Epub 2019 Jan 9.

West China School of Public Health and Healthy Food Evaluation Research Center, Sichuan University, Chengdu, People's Republic of China.

Live vector-based vaccine is a modern approach to overcome the drawbacks of inactivated foot-and-mouth disease (FMD) vaccines such as improper inactivation during manufacture. Listeria monocytogenes (LM), an intracellular microorganism with immune-stimulatory properties, is appropriate to be utilized as a live bacterial vaccine vector. FMDV-VP1 protein has the capability to induce both cellular and humoral immune responses since it is considered the most immunogenic part of FMDV capsid and has the most of antigenic sites for viral neutralization. Read More

World J Clin Oncol 2019 Jan;10(1):1-13

University at Buffalo, The State University of New York, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY 14214, United States.

Xerostomia, or dry mouth, is a significant problem affecting quality of life in patients treated with radiation therapy for head and neck cancer. Strategies for reduction of xerostomia burden vary widely, with options including: sialagogue medications, saliva substitutes, acupuncture, vitamins, hyperbaric oxygen, submandibular gland transfer, and acupuncture or associated treatments. In this review, we sought to evaluate long-term outcomes of patients treated with various interventions for radiation-induced xerostomia. Read More

IDCases 2019 29;15:e00484. Epub 2018 Dec 29.

Department of Pulmonary and Critical Care Medicine, University of Tennessee Graduate School of Medicine, Knoxville, USA.

We report a patient with Ehlers-Danlos syndrome and mitral valve infective endocarditis. The case was complicated due to multiorgan involvement and initially diagnosed as hand-foot-and-mouth disease. The patient was transferred to our hospital with cerebral septic emboli and bilateral lower extremity emboli requiring early surgery. Read More

Case Rep Dent 2018 29;2018:4736495. Epub 2018 Nov 29.

Clinical Assistant Professor, Department of Biological and Material Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.

Hypohidrotic ectodermal dysplasia (HED) is a rare congenital disorder that associates with dental manifestations of anodontia, hypodontia, and atrophic alveolar ridges. Although the disorder does not affect the life expectancy of the patient, it poses tremendous challenges on the patient's physical and psychosocial development. Early and multidisciplinary dental care can benefit HED children's development and improve their quality of life. Read More

Front Immunol 2018 21;9:2956. Epub 2018 Dec 21.

Departamento de Investigación en Microbiología, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.

is a commensal fungus that can cause disease ranging in severity from moderate to severe mucosal infections to more serious life-threating disseminated infections in severely immunocompromised hosts. Chronic mucocutaneous candidiasis (CMC) occurs in patients with mutations in genes affecting IL-17-mediated immunity, such as , and , or gain of function (GOF) mutations in . New strategies for the treatment of candidiasis are needed because of the increased burden of infections and the emergence of drug-resistant strains. Read More

Case Rep Oncol 2018 Sep-Dec;11(3):769-776. Epub 2018 Nov 27.

University Hospital of São João, Porto, Portugal.

Advanced head and neck squamous cell carcinoma, after locoregional treatment and multiple lines of systemic therapies, represents a great challenge to overcome acquired resistance. The present clinical case illustrates a successful treatment option and is the first to describe the use of photodynamic therapy (PDT) with Redaporfin, followed by immune checkpoint inhibition with an anti-PD1 antibody. This patient presented an extensive tumor in the mouth pavement progressing after surgery, radiotherapy, and multiple lines of systemic treatment. Read More

Sci Rep 2019 Jan 9;9(1). Epub 2019 Jan 9.

GEOMAR Helmholtz-Centre for Ocean Research Kiel, Evolutionary Ecology of Marine Fishes, Düsternbrooker Weg 20, 24105, Kiel, Germany.

While originally acquired from the environment, a fraction of the microbiota is transferred from parents to offspring. The immune system shapes the microbial colonization, while commensal microbes may boost host immune defences. Parental transfer of microbes in viviparous animals remains ambiguous, as the two transfer routes (transovarial vs. Read More

Acta Odontol Scand 2019 Jan 10:1-8. Epub 2019 Jan 10.

e Department of Physiotherapy , Universidad Cardenal Herrera-CEU, CEU Universities , Valencia , Spain.

Objective: This study aimed to assess mechanical hyperalgesia in the trigeminal and extra-trigeminal regions in patients with chronic migraine (CM) and temporomandibular disorders (TMD) in comparison to asymptomatic subjects and to determine the association between sensorimotor variables and psychological and disability variables and evaluate the prediction of a sensorimotor variables though psychological and disability variables in patients with CM and TMD.

Material And Methods: A total of 52 subjects with concomitant CM and TMD and 30 asymptomatic subjects were included in the study. The pressure pain threshold (PPT), maximal mouth opening (MMO) and a series of self-reported factors were compared. Read More

Sci Total Environ 2019 Mar 27;656:1358-1364. Epub 2018 Nov 27.

Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Background: Prior studies have shown that climate factors and air pollution are associated with hand, foot, and mouth disease (HFMD) epidemics. However, the interaction between air pollution and climate factors remains unknown.

Methods: Daily HFMD counts from 2009 through 2012 in Guangdong were collected. Read More

Laryngorhinootologie 2019 Jan 9. Epub 2019 Jan 9.

Klinik für Hals-, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Ulm.Ärztlicher Direktor: Prof. Dr. med. Thomas Hoffmann.

Objective: In this study, symptoms associated with adenoids and hyperplasic palatine tonsils and parental expectation of surgical outcome were recorded, to provide realistic parental information prior to adenoidectomy (AT) ± tonsillotomy (ATT).

Material And Methods: In total n = 111 children (3-6 years, ♂ 65 % ♀ 35 %) were recruited, who received AT (66 %) or ATT (34 %) at ENT University Hospital Ulm. By questionnaire-based survey, the most common symptoms and the main reason for the operation were reported from parent's perspective (operation day, follow-up: 3. Read More

Equine Vet J 2019 Jan 9. Epub 2019 Jan 9.

Department of Agro-Forestry Sciences, ETSIA, University of Seville, Road Utrera Km 1, 41013, Seville, Spain.

Background: Vitiligo and melanoma are relatively common disorders in grey Pura Raza Español horses and other horse breeds with grey-coloured coats.

Objectives: To determine the breed prevalence, environmental risks factors and estimate the genetic parameters for vitiligo and melanoma in Pura Raza Español horses.

Study Design: Retrospective cohort study. Read More

J Appl Oral Sci 2019 Jan 7;27:e20180163. Epub 2019 Jan 7.

Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Ciências Biológicas, Bauru, São Paulo, Brasil.

Objective: Microcosm biofilm has been applied to induce carious lesions in dentin. However, no study has been done to compare the impact of the type of model for providing nutrients to microcosm biofilm formation on dentin. This study compared the performance of two kinds of models (static and semi-dynamic) on the biofilm formation and the development of dentin carious lesions. Read More

Growth Factors 2019 Jan 9:1-7. Epub 2019 Jan 9.

d Department of Periodontology, Faculty of Dentistry , Recep Tayyip Erdogan University , Rize , Turkey.

The present study evaluates the effects of leukocyte-platelet-rich fibrin (L-PRF) combined with open flap debridement (OFD) on clinical parameters and growth factors levels (GFL) in chronic periodontitis (CP) patients. This trial was registered at clinicaltrials.gov as NCT02594605. Read More

Acta Odontol Scand 2019 Jan 9:1-8. Epub 2019 Jan 9.

a Department of Surgical Sciences , C.I.R. Dental School University of Turin , Turin , Italy.

Objective: The aim of this cross-sectional study was to assess the bias in estimating the prevalence of periodontitis due to partial-mouth periodontal examination protocols (PMPE) and to relate the severity and extent of periodontal damage to periodontitis misclassification when applying case definitions by Centres of Disease Control and Prevention and American Academy of Periodontology (CDC/AAP).

Materials And Methods: A full-mouth periodontal examination (FMPE) was performed in 721 adults living in North Italy to identify moderate and severe periodontitis. These results were compared with those obtained with two PMPE protocols analyzing two interproximal sites on all teeth (fMB-DL) or four interproximal sites in two random diagonal quadrants (pMDB-MDL). Read More