Search Our Scientific Publications & Authors

Head Neck 2020 Jul 11. Epub 2020 Jul 11.

Department of Maxillofacial Surgery and Stomatology of Pr Chossegros, APHM, CHU Conception, Marseille, France.

Background: Although many studies focus on short-term side effects of radioiodine therapy, almost none studied long-term side effects. We assessed radioiodine long-term salivary side effects after radioiodine treatment for differentiated papillary thyroid carcinoma and compared it to short-term morbidity within the same population.

Methods: A standardized self-administrated questionnaire was submitted in 2019 by patients treated with radioiodine between January 2011 and December 2012. Read More

J Oral Pathol Med 2020 Jul 11. Epub 2020 Jul 11.

Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK.

Background: Long-term follow-ups after receiving lycopene therapy for management of Oral Submucous Fibrosis (OSMF) are scarce. The study aimed to assess the long-term efficacy of lycopene for management of OSMF symptoms.

Methods: In this prospective clinical study, 400 clinically diagnosed early OSMF patients were assessed for the efficacy of lycopene in alleviation of burning sensation (BS) and reduced mouth opening (MO) symptoms in comparison to placebo. Read More

J Oral Maxillofac Surg 2020 Jun 15. Epub 2020 Jun 15.

Radiation Oncologist, Voice and Swallowing Center, Department of Otolaryngology - Head and Neck Surgery and Department of Radiation Oncology, University of Cincinnati College of Medicine; and Research Service, Cincinnati Veteran's Affairs Medical Center, Cincinnati, OH. Electronic address:

Purpose: Although a standard cutoff value of less than 35 mm in the maximum mouth opening (MMO) has been used to diagnose trismus, this value does not account for natural demographic variations. The present cross-sectional study investigated the effects of age, weight, height, body mass index (BMI), and gender on the MMO in a healthy, heterogeneous population.

Materials And Methods: A volunteer sample from multiple sites in Cincinnati, Ohio, without any reported head and neck pathologies or current dental prostheses and with intact natural incisors were included. Read More

Cardiovasc Intervent Radiol 2020 Jul 10. Epub 2020 Jul 10.

Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100021, China.

Purpose: To evaluate the technical feasibility of fluoroscopy-guided gastrojejunostomy creation in a porcine model.

Methods: Eight domestic female pigs (median, 15.6 kg; range, 14. Read More

Mol Cell Proteomics 2020 Jul 10. Epub 2020 Jul 10.

King's College London.

Natural compounds that can stimulate salivary secretion are of interest in developing treatments for xerostomia, the perception of a dry mouth, that affects between 10 and 30% of the adult and elderly population.  Chemesthetic transient receptor potential (TRP) channels are expressed in the surface of the oral mucosa. The TRPV1 agonists capsaicin and piperine have been shown to increase salivary flow when introduced into the oral cavity but the sialogogic properties of other TRP channel agonists have not been investigated. Read More

J Diabetes Complications 2020 Jul 2:107670. Epub 2020 Jul 2.

Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, Chennai, India. Electronic address:

Oral cancer and diabetes are highly prevalent among the Indian population and are part of the top four non-communicable diseases responsible for mortality and morbidity. Their numbers are so great that they pose a unique burden to the socioeconomic growth of the country. In recent years, there has been an increase in the number of studies examining the role of diabetes in oral cancer reporting co-existence of diabetes and cancer. Read More

Trials 2020 Jul 10;21(1):634. Epub 2020 Jul 10.

The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, 246 Heping Road, Hefei, China.

Background: The prevalence of pneumonia complicating stroke in acute phase has a poor prognosis and higher risk for death. Oral opportunistic pathogens have been reported to be associated with pneumonia among people with compromised health. Oral health promotion is effective in reducing dental plaque among patients with stroke, which is considered as reservoirs for oral opportunistic pathogens. Read More

BMC Oral Health 2020 Jul 10;20(1):199. Epub 2020 Jul 10.

Clinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Egas Moniz, CRL, Quinta da Granja, Almada, 2829 - 511, Portugal.

Background: To investigate if self-perceived xerostomia and stress are significant variables on the Oral-Health Related Quality of Life (OHRQoL) of elderly patients, considering the periodontal status, oral hygiene habits and sociodemographic characteristics simultaneously.

Methods: The study cohort included 592 participants (320 females/272 Males), aged 65 years or older, representing the elder inhabitants of the Study of Periodontal Health in Almada-Seixal (SoPHiAS). Patients answered a socio-demographic and oral hygiene habits questionnaire. Read More

Int J Soc Psychiatry 2020 Jul 10:20764020941889. Epub 2020 Jul 10.

Department of Psychology, School of Humanities and Society Sciences, Ibn Haldun University, Istanbul, Turkey.

Aim: The aim of this study was to investigate the association between the COVID-19 pandemic and psychological fatigue as a mental health issue among the population of Istanbul, Turkey.

Participants And Methods: This is a cross-sectional study conducted in Istanbul, Turkey, between March and June 2020, where a total of 4,700 persons were approached and 3,672 (78%) of participants (64.4% males and 35. Read More

J Oral Maxillofac Surg 2020 Jun 13. Epub 2020 Jun 13.

▪▪▪, Department of Oral Health Sciences-Orthodontics, KU Leuven, Leuven, Belgium; and Dentistry, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Ankylosis of the temporomandibular joint (TMJ) is defined as the emergence of a bony or fibrous compound between the condyle and the cranial base. It can result in divergent craniofacial characteristics. The aim of this study was to present an orthodontic-surgical approach in a case series of 4 patients with a diagnosis of TMJ ankylosis as a complication of otomastoiditis. Read More

Med Sci Monit 2020 Jul 10;26:e924982. Epub 2020 Jul 10.

Department of Orthopedic, Nanjing First Hospital, Nanjing, Jiangsu, China (mainland).

BACKGROUND This was a prospective comparative study of mixed reality (MR) technology assisted lumbar pedicle screws placement and traditional lumbar pedicle screws placement. MATERIAL AND METHODS Fifty cases of lumbar pedicle screws placement were randomly divided into 2 groups: 25 cases with MR technology in group A, and 25 cases without MR technology in group B. All patients had their scores on the Oswestry disability index (ODI) of low back pain and the visual analog scale (VAS) of the affected lower limb recorded at pre-operation. Read More

Subst Use Misuse 2020 Jul 9:1-8. Epub 2020 Jul 9.

Department of Health, Behavior and Society, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.

Background: Rates of death from opioid overdose continue to rise in the United States. One harm reduction strategy designed to reduce fatal overdose risk among people who inject drugs (PWID) is an advisory to not use drugs alone. However, the feasibility and acceptability of this message have not been evaluated. Read More

Pathogens 2020 Jul 7;9(7). Epub 2020 Jul 7.

Department of Odontology, Umeå University, 901 87 Umeå, Sweden.

Bacteria colonizing the mouth induce an adaptive immune response with the systemic and local presence of species or strain-specific immunoglobulins. Few studies have addressed global antibody patterns for oral bacteria or potential population time trends. We assessed these aspects in relation to a panel of oral bacteria. Read More

Eur J Dent 2020 Jul 9. Epub 2020 Jul 9.

Department of Oral and Craniofacial Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.

Objectives:  To analyze CD35/CD89 expression ratio on the surface of neutrophils as an early detection marker for S-ECC.

Materials And Methods:  Saliva was collected from 4- to 6-year-old kindergarten students. Salivary neutrophils were obtained by instructing the subjects to rinse their mouth with 1 mL of sterile 1. Read More

PLoS One 2020 9;15(7):e0235969. Epub 2020 Jul 9.

Department of Agriculture, Animal Health Epidemiology, Canberra, ACT, Australia.

Decisions surrounding the presence of infectious diseases are typically made in the face of considerable uncertainty. However, the development of models to guide these decisions has been substantially constrained by computational difficulty. This paper focuses on the case of finding the optimal level of surveillance against a highly infectious animal disease where time, space and randomness are fully considered. Read More

J Appl Physiol (1985) 2020 Jul 9. Epub 2020 Jul 9.

Institute of Exercise Physiology and Respiratory Medicine, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, United States.

Introduction: This paper assessed the blood pressure, heart rate, and mouth-pressure responses to indoor rock climbing (bouldering) and associated training exercises.

Case Presentation: Six well-trained male rock climbers (mean ± SD age = 27.7 ± 4. Read More

Cancer Med 2020 Jul 9. Epub 2020 Jul 9.

Center of Expertise in Palliative Care, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University Utrecht, The Netherlands.

Background: The Utrecht Symptom Diary (USD) is a Dutch and adapted version of the Edmonton Symptom Assessment System, a patient-reported outcome measurement (PROM) tool to asses and monitor symptoms in cancer patients. This study analyses the validity and responsiveness of the USD and the cutoff points to determine the clinical significance of a symptom score.

Methods: Observational longitudinal cohort study including adult in- and outpatients treated in an academic hospital in the Netherlands who completed at least one USD as part of routine care (2012-2019). Read More

Oral Dis 2020 Jul 9. Epub 2020 Jul 9.

Mucosal and Salivary Biology Division, Dental Institute, King's College London, United Kingdom.

Objectives: The early diagnosis and monitoring of Crohn's disease (CD) and orofacial granulomatosis (OFG) might be facilitated by assaying potential disease biomarkers in saliva. Markers of oxidative stress and inflammation were assayed in salivas from patients with CD, OFG and concurrent OFG and CD (OFG+CD).

Subjects: Unstimulated whole mouth saliva was collected from 93 subjects and immunoglobulin A (IgA), lactoferrin (LF) and myeloperoxidase (MPO) were determined by ELISA. Read More

J Mater Chem B 2020 Jul 9. Epub 2020 Jul 9.

State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P. R. China. and School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, P. R. China and PLA Key Laboratory of Biopharmaceutical Production and Formulation Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P. R. China and Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing 210008, P. R. China.

To generate effective immunity post-vaccination, antigens need to be effectively captured and taken up by antigen-presenting cells (APCs) as a prerequisite. Biomimetic designs that mimic natural pathogen-like properties have provided platforms for antigen delivery. However, the structural dynamic properties of pathogens leading to their efficient internalization have been neglected in most platforms. Read More

Prim Dent J 2020 Jun;9(2):38-46

Consultant diabetologist, Department of diabetes, King's College Hospital, Denmark Hill, London.

Diabetes mellitus is a condition resulting from loss of production of insulin, or insufficient production/insulin resistance leading to high blood glucose levels. Management of the condition can be provided in a variety of settings and is tailored to the person's requirements. The condition has a lifelong, systemic impact due to microvascular and macrovascular complications. Read More

J Periodontal Implant Sci 2020 Jun 5. Epub 2020 Jun 5.

Dental Research Institution, Seoul National University School of Dentistry, Seoul, Korea.

Purpose: Many home care treatments can be used to promote the health and longevity of dental implants; however, few studies are available to support the concept that self-performed oral hygiene behaviors are an essential tool for improving and maintaining oral health. We investigated age-stratified associations between dental health behaviors related to tooth brushing (TB) and oral hygiene product use in Korean adults with implants.

Methods: A total of 1,911 subjects over 19 years of age who had 1 or more implants and who participated in the 2013 to 2015 Korea National Health and Nutrition Examination Survey were reviewed. Read More

Infect Dis Ther 2020 Jul 8. Epub 2020 Jul 8.

Labor Prof. Dr. G. Enders MVZ GbR, Stuttgart, Germany.

Introduction: As of 22 June 2020, Severe Acute Respiratory Syndrome (SARS)-coronavirus (CoV)-2 has infected more than 8.95 million people worldwide, causing > 468,000 deaths. The virus is transmitted through respiratory droplets and physical contact from contaminated surfaces to the mucosa. Read More

Clin Oral Investig 2020 Jul 8. Epub 2020 Jul 8.

Department of Periodontology, Faculty of Dentistry, University of Marmara, 34854 Maltepe, Istanbul, Turkey.

Objective: Angiogenesis is essential in maintenance of periodontal homeostasis, and it is regulated by growth factors and cytokines, including basic fibroblast growth factor (b-FGF), endoglin, platelet and endothelial cell adhesion molecule (PECAM-1), vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1). In this study, the salivary and serum concentrations of these angiogenesis-related proteins in relation to smoking and periodontitis were examined.

Material And Methods: Full-mouth periodontal status together with unstimulated whole saliva and serum samples was collected from 78 individuals, including 40 periodontitis patients (20 smokers and 20 nonsmokers) and 38 periodontally healthy controls (20 smokers and 18 nonsmokers). Read More

Lab Anim Res 2020 2;36:19. Epub 2020 Jul 2.

Xenotransplantation Research Center, 103 Daehar-ro Jongno-gu, Seoul, 110-799 Korea.

Background: Ankylosis in the temporomandibular joint (TMJ) is known to have various etiologies in veterinary medicine. We observed a case of fibrous ankylosis of the TMJ in a newly imported rhesus monkey ().

Case Presentation: Moderate to severe attrition was found in the middle labial portion of the left maxillary canine. Read More

J Thorac Dis 2020 May;12(5):2553-2562

Department of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.

Background: The best ventilator mode for patients receiving non-invasive ventilation (NIV) has not been clarified. This study compared the effectiveness of two pressure-targeted modes, i.e. Read More

Craniomaxillofac Trauma Reconstr 2020 Jun 17;13(2):99-104. Epub 2020 Mar 17.

ITS Dental College, Ghaziabad, Uttar Pradesh, India.

The purpose of the study was to compare 2 techniques of arthrocentesis, to find out the efficacy of one over the other at various parameters, and to contribute to the scarce literature of these 2 techniques. Forty patients reported with a chief complaint of pain in temporomandibular joint (TMJ), clicking in TMJ, and restricted mouth opening were included in this study. Twenty patients were divided into 2 groups, all reporting with temporomandibular disorders. Read More

Craniomaxillofac Trauma Reconstr 2020 Mar 27;13(1):59-70. Epub 2020 Feb 27.

European Face Centre, University Hospital Brussels, Brussels, Belgium.

Purpose: This article aims to compare the difference in postoperative results in patients treated with either a patient-specific (PSI) or a stock temporomandibular total joint replacement system.

Materials And Methods: The investigators performed a systematic review concerning postoperative results after placement of either a stock total joint replacement system or a PSI. PubMed Central, Web of Science, Cochrane Library Plus, Wiley Online Library, and EMBASE were used to conduct this search. Read More

BMJ Case Rep 2020 Jul 8;13(7). Epub 2020 Jul 8.

Centre for Dental Education and Research, AIIMS, New Delhi, India

Lamellar ichthyosis (LI) is a rare genetic condition that affects the skin, with an incidence of less than 1:300 000 in different parts of the world. This report describes a case of a 5-year-old girl with LI and rickets presenting with premature loss of 51, 52, 61, 62 and 71, grade II mobility in 72, 73, 81, 82 and 83 along with loss of supporting bone with 53, 63, 72, 73, 82 and 83. This is the first report describing oral manifestations of this combination of LI and rickets. Read More

Biomed J 2020 Jul 5. Epub 2020 Jul 5.

Division of Pediatric Neurology, Chang Gung Children's Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

In this review, we summarize the general mechanisms of the ketogenic diet, and the application of a ketogenic diet in pediatric intensive care units for the neurological disorders of children and young infants. A ketogenic diet is a high-fat, low-carbohydrate, adequate-protein diet. It can alter the primary cerebral energy metabolism from glucose to ketone bodies, which involves multiple mechanisms of antiepileptic action, antiepileptogenic properties, neuro-protection, antioxidant and anti-inflammatory effects, and it is potentially a disease-modifying intervention. Read More

Biomed Environ Sci 2020 Jun;33(6):421-430

Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Objective: We aimed to assess the features of notifiable infectious diseases found commonly in foreign nationals in China between 2004 and 2017 to improve public health policy and responses for infectious diseases.

Methods: We performed a descriptive study of notifiable infectious diseases among foreigners reported from 2004 to 2017 in China using data from the Chinese National Notifiable Infectious Disease Reporting System (NNIDRIS). Demographic, temporal-spatial distribution were described and analyzed. Read More

BMC Microbiol 2020 Jul 8;20(1):201. Epub 2020 Jul 8.

Oral Microbiome Research Laboratory, Department of Oral Health Sciences, Maurice H. Kornberg School of Dentistry, Temple University, Philadelphia, PA, USA.

Background: The possibility that smokeless tobacco may contribute to oral carcinogenesis by influencing the oral microbiome has not been explored. This preliminary cross-sectional study sought to assess the effect of using shammah, a form of smokeless tobacco prevalent in Arabia, on the tongue microbiome. Tongue scarping samples were obtained from 29 shammah users (SU; 27. Read More

Perspect Public Health 2020 Jul;140(4):190-191

Chief Executive of the Oral Health Foundation Oral Health Foundation, Smile House, 2 East Union Street, Rugby, Warwickshire, CV22 6AJ, UK.

J Oral Rehabil 2020 Jul 8. Epub 2020 Jul 8.

Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.

Background: Symptomatic disc displacement (DD) of the temporomandibular joint (TMJ) may cause pain and limited mouth opening. The aetiopathogenesis is obscure and probably complex, which makes the diagnostic classification crude and mainly based on clinical criteria rather than disease mechanisms, and tissue characteristics.

Objectives: The study aim was to characterise and quantify synovial tissue in DD, where specific cytokine patterns might serve as potential biomarkers. Read More

Indian J Pediatr 2020 Jul 7. Epub 2020 Jul 7.

Department of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, India.

Objective: Oral care with mother's own milk (OC-MOM) in sick and preterm neonates provides immune protection, improves feed tolerance and helps in earlier achievement of full enteral nutrition. This quality improvement (QI) initiative was undertaken when authors documented scanty awareness regarding neonatal oral care practices among care-givers in their neonatal unit. The project aimed to improve the proportion of OC-MOM in sick and preterm neonates from the baseline of 5. Read More

Front Vet Sci 2020 19;7:340. Epub 2020 Jun 19.

USDA-ARS, Foreign Animal Disease Research Unit, Plum Island Animal Disease Center, Orient, NY, United States.

Foot-and-mouth disease virus (FMDV) causes persistent infection of nasopharyngeal epithelial cells in ~50% of infected ruminants. The mechanisms involved are not clear. This study provides a continued investigation of differentially expressed genes (DEG) identified in a previously published transcriptomic study analyzing micro-dissected epithelial samples from FMDV carriers and non-carriers. Read More

Porcine Health Manag 2020 6;6:20. Epub 2020 Jul 6.

Department of Veterinary Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, 10330 Thailand.

Asia is a major pig producer of the world, and at present, African swine fever virus (ASFV) continues to significantly impact the Asian pig industry. Since more than 50% of the world's pig population is in Asia, ASFV outbreaks in Asia will affect the global pig industry. Prior to the introduction of ASF, several outbreaks of major swine viruses occurred in Asia over the last two decades, including porcine reproductive and respiratory syndrome virus (PRRSV), porcine epidemic diarrhea virus (PEDV) and foot and mouth disease virus (FMDV). Read More

Vet World 2020 May 14;13(5):890-895. Epub 2020 May 14.

Department of Animal Medicine, Faculty of Veterinary Medicine, Alexandria University, Egypt.

Background And Aim: Foot-and-mouth disease (FMD) causes huge economic losses in Egypt due to reductions in the production of red meat, milk, and milk by-products and can also lead to myocarditis in young animals. The aim of our study was to evaluate cardiac biomarkers, in particular cardiac troponin I (cTnI), and to reveal the relations of cardiac biomarkers with poor survival in FMD-infected Egyptian buffalo calves.

Materials And Methods: Forty-two Egyptian buffalo calves were included in this study. Read More

Ann Rev Mar Sci 2020 Jul 7. Epub 2020 Jul 7.

School of Oceanography, University of Washington, Seattle, Washington 98195, USA; email:

Sediment transfer from land to ocean begins in coastal settings and, for large rivers such as the Amazon, has dramatic impacts over thousands of kilometers covering diverse environmental conditions. In the relatively natural Amazon tidal river, combinations of fluvial and marine processes transition toward the ocean, affecting the transport and accumulation of sediment in floodplains and tributary mouths. The enormous discharge of Amazon fresh water causes estuarine processes to occur on the continental shelf, where much sediment accumulation creates a large clinoform structure and where additional sediment accumulates along its shoreward boundary in tidal flats and mangrove forests. Read More

Cancers (Basel) 2020 Jul 3;12(7). Epub 2020 Jul 3.

Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.

Background: Sentinel lymph node biopsy (SLNB) has been introduced as a diagnostic staging modality for detection of occult metastases in patients with early stage oral cancer. Comparisons regarding accuracy to the routinely used elective neck dissection (END) are lacking in literature.

Methods: A retrospective, multicenter cohort study included 390 patients staged by END and 488 by SLNB. Read More

Polymers (Basel) 2020 Jul 3;12(7). Epub 2020 Jul 3.

Department of Mechanical Engineering, University of Coimbra, CEMMPRE, 3030-788 Coimbra Portugal.

Athletes from contact sports are more prone to orofacial injuries because of the exposure to possible shocks and collisions derived from physical proximity. The use of protector polymeric mouthguards proved to be useful in the prevention of the described injuries. There are different types of mouthguards with varying ranges of protection and prices, but they are all made from polymers and share the same propose: to absorb and dissipate the impact energy resulting from the shocks. Read More

Foods 2020 Jul 3;9(7). Epub 2020 Jul 3.

Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), 46980 Valencia, Spain.

When food is ingested, it remains in the mouth for a short period of time. Although this period is brief compared to the total food nutrient digestion and absorption time, it is crucially important as it is the first step in digestion. It is also very important that, while the food is in the mouth, it is perceived by the senses and then a decision is made on swallowing. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2020 Jul;55(7):433-438

Salivary Gland Diseases Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China.

Dietary nitrate which mainly comes from green leafy vegetables, is absorbed into blood circulation by the intestinal mucosa. Parotid gland is an important organ for transporting nitrate. Nitrate in blood is taken up by sialin, a nitrate transporter and concentrated in salivary glands and secreted into saliva. Read More

Prev Vet Med 2020 Jun 29;181:105082. Epub 2020 Jun 29.

Instituto Nacional de Investigación Agropecuaria (INIA), Plataforma de Investigación en Salud Animal, Estación Experimental La Estanzuela, Colonia, Uruguay.

Foot-and-mouth disease (FMD) is highly contagious, and the introduction of FMD virus in countries free of the disease can result in large epidemics, similar to those observed in the United Kingdom, Japan, and Uruguay. Many countries or regions of South America are recognized as "FMD-free with vaccination" or "FMD-free without vaccination." Uruguay has been certified as FMD-free with vaccination, and the transition to the status of FMD-free without vaccination has been discussed among the stakeholders of the Ministry of Livestock Agriculture and Fisheries (MGAP in Spanish). Read More

Int J Infect Dis 2020 Jul 4. Epub 2020 Jul 4.

Department of Epidemiology and Biostatistics, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Little is known about the association between genetic susceptibility and the severity of hand, foot, and mouth disease (HFMD) infected with coxsackievirus A6 (CV-A6).

Methods: Totally, 364 CV-A6 HFMD patients were enrolled, including 115 severe and 249 mild patients. A genome-wide association study (GWAS) was performed involving eight DNA pools of 115 severe and 115 mild CV-A6 HFMD patients pair-matched by age and gender. Read More