Exp Neurol 2022 07 2;353:114030. Epub 2022 Mar 2.
Department of Physiology & Biomedical Engineering, College of Medicine and Science, Mayo Clinic, Rochester, MN, United States of America; Department of Anesthesiology & Perioperative Medicine, College of Medicine and Science, Mayo Clinic, Rochester, MN, United States of America. Electronic address:
Upper cervical spinal cord injuries (SCI) disrupt descending inputs to phrenic motor neurons (PhMNs), impairing respiratory function. Unilateral spinal hemisection at C2 (C2SH) results in loss of ipsilateral rhythmic diaphragm muscle (DIAm) EMG activity associated with lower force behaviors accomplished by recruitment of smaller PhMNs in rats. Activity during higher force, non-ventilatory behaviors that recruit larger PhMNs is minimally impaired following C2SH. Read More