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Eur Radiol 2022 Jun 21. Epub 2022 Jun 21.

Department of Orthopedic Surgery, University Hospital Virgen de las Nieves, Granada, Spain.

Objectives: This work compares the effectiveness of blind versus ultrasound (US)-guided injections for Morton neuroma (MN) up to 3 years of follow-up.

Methods: This is an evaluator-blinded randomised trial in which 33 patients with MN were injected by an experienced orthopaedic surgeon based on anatomical landmarks (blind injection, group 1) and 38 patients were injected by an experienced musculoskeletal radiologist under US guidance (group 2). Patients were assessed using the visual analogue scale and the Manchester Foot Pain and Disability index (MFPDI). Read More

Acta Biomed 2022 03 10;92(S3):e2021556. Epub 2022 Mar 10.

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The aim of this study is to systematically review the literature on clinical outcomes of patients who have undergone infiltrative therapy for treatment of Morton's neuroma. As many kinds of substances are injected, the main outcome defines which treatment provides the best results in term of patient's satisfaction and pain relief, so that it would be possible to choose the best option. Many electronic databases were searched on July 2021; we have included prospective and retrospective case series, and randomized controlled trials of infiltrative treatments in patients with primary diagnosis of Morton's neuroma. Read More

Cureus 2022 Jan 30;14(1):e21751. Epub 2022 Jan 30.

Medicina Física e de Reabilitação, Centro Hospitalar e Universitário de Coimbra, Coimbra, PRT.

A 63-year-old female patient, with a past history of rheumatoid arthritis, presented with insidious pain on the left foot second and third metatarsophalangeal joints, associated with swelling and morning stiffness (mean time: four hours). Physical examination evidenced a tender and soft nodularity in the third intermetatarsal space, along with sharp pain, consistent with Morton's neuroma. Foot ultrasound suggested Morton's neuroma, but not excluding the possibility of rheumatoid arthritis involvement. Read More

QJM 2022 04;115(4):243-244

Department of Rheumatology, NTT Sapporo Medical Centre, Minami 1, Nishi 15, Chuo-ku, Sapporo 060-0061, Japan.

Plast Reconstr Surg Glob Open 2022 Jan 27;10(1):e4035. Epub 2022 Jan 27.

Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.

Morton's neuroma (MN) is a painful, proliferative fibrosis of perineural tissue caused by pressure or recurrent irritation that was previously thought to affect only the common interdigital nerve of the foot. We present a case of a bilateral MN of both the ulnar and radial proper digital nerves of the fifth finger in a 30-year-old patient, following multiple surgeries on the aforementioned finger. The patient was referred to our center by a peripheral hospital after traumatic fingertip amputation distal the DIP joint, where the fingertip was initially simply sutured. Read More

Clin Podiatr Med Surg 2021 Jan 18;38(1S):e24-e30. Epub 2021 Nov 18.

Peripheral Nerve Reconstructive Microsurgery, American Microsurgical Orthoplastic Society, Department of Surgery, Amita Saint Joseph Hospital, Laboure Outpatient Clinic, 2913 North Commonwealth Avenue, Chicago, IL 60657, USA.

Morton's neuroma is a common painful pathology that occurs in the plantar forefoot. Many treatment options exist and surgical management is used after conservative treatment options fail. While within the literature, there is a high success rate with primary neurectomy procedures, the risk of recurrence of symptoms or "stump neuromas" remains difficult to treat and can lead to debilitating pain. Read More

J Orthop Surg Res 2022 Jan 15;17(1):22. Epub 2022 Jan 15.

Chelsfield Park Hospital, Bucks Cross Road, Chelsfield, Orpington, Kent, BR6 7RG, UK.

Background: Morton's neuroma (MN) is a common cause of forefoot pain. After failure of conservative management, surgical procedures include neurectomy or neuroma preserving procedures; resection of deep transverse intermetatarsal ligament only (DTIML), dorsal neurolysis, dorsal nerve transposition (DNT).

Objectives: This retrospective study evaluates the long-term results of open DNT, and it also reports anatomical variants in the plantar interdigital nerve. Read More

Ultrasonography 2022 Apr 25;41(2):225-242. Epub 2021 Oct 25.

Daegyeong Imaging and Healthcare Center, Daegu, Korea.

Ultrasonography (US) is a useful diagnostic method that can be easily applied to identify the cause of metatarsalgia. The superficial location of structures in the foot, dynamic capability of US, and the ability to perform direct real-time evaluations of the pain site are also strong advantages of US as a modality for examining the foot. Moreover, knowing the possible pain sources to investigate when a patient has a specific site of pain will enhance the diagnostic quality of US, and will help radiologists to perform US efficiently and effectively. Read More

J Foot Ankle Res 2021 Dec 4;14(1):62. Epub 2021 Dec 4.

Department of Orthopedics, Balgrist University Hospital, University of Zurich, Forchstrasse 340, 8008, Zurich, Switzerland.

Background: The aim of this retrospective study was to examine if a correlation between Morton's Neuroma (MN) and an increased interphalangeal angle (IPA) or intermetatarsal angle (IMA) can be found in preoperative weightbearing dorsal-plantar X-rays of the foot.

Methods: Forty-five patients with forty-nine MN in the interspaces 2/3 or 3/4 and 49 controls were recruited for this study. Every MN was matched with an asymptomatic control without history of metatarsalgia. Read More

Foot Ankle Spec 2022 Feb 2;15(1):76-81. Epub 2021 Dec 2.

Department of Plastic Surgery, The University of Virginia, Charlottesville, Virginia (SIK, CVS, BRD).

Background: Despite multiple surgical modalities available for the management of Morton's neuroma, complications remain common. Targeted muscle reinnervation (TMR) has yet to be explored as an option for the prevention of recurrence of Morton's neuroma. The purpose of the present investigation was to determine the consistency of the relevant foot neurovascular and muscle anatomy and to demonstrate the feasibility of TMR as an option for Morton's neuroma. Read More

J Foot Ankle Surg 2021 Oct 22. Epub 2021 Oct 22.

Department of Orthopedics, Clinica Moncucco SA, Lugano, Switzerland.

Longitudinal plantar approaches are generally considered at risk for wound healing problems. Thus, we wanted to investigate long-term outcomes after a primary Morton's neuroma excision through a longitudinal plantar approach. A retrospective study of patients with primary neuroma excision was conducted. Read More

Foot Ankle Surg 2022 Jun 27;28(4):450-459. Epub 2021 Oct 27.

Department of Orthopedic Surgery, Inje University, Ilsan Paik Hospital, 170 Juhwa-ro, Ilsanseo-gu, Goyang-si, Gyeonggi-do, South Korea. Electronic address:

Background: The effectiveness of operative treatments other than neurectomy for Morton's neuroma remains debatable despite several reported studies. This review aimed to evaluate the effects of operative treatments for Morton's neuroma other than neurectomy using an algorithmic approach and a structured critical framework to assess the methodological quality of reported studies.

Methods: Several electronic databases were searched for articles published until August 2021 that evaluated the outcomes of operative treatments other than neurectomy in patients diagnosed with Morton's neuroma. Read More

J Foot Ankle Surg 2022 Jan-Feb;61(1):163-169. Epub 2021 Aug 20.

Consultant (Attending) in Trauma and Orthopaedics, Department of Trauma and Orthopaedic Surgery, University Hospitals Leicester NHS Trust, Leicester, United Kingdom.

The optimal treatment strategy for the presentation of multiple Morton's neuromas in adjacent intermetatarsal spaces of the same foot is yet to be determined. We aimed to summarize and assess the efficacy of current treatment strategies. A systematic review, adhering to PRIMSA guidelines was performed. Read More

AJR Am J Roentgenol 2022 02 15;218(2):234-240. Epub 2021 Sep 15.

Department of Radiology, New York University-Langone Health, New York, NY.

. Morton neuroma is a common, painful disorder of the foot with multiple treatment options of varying cost and effectiveness. . Read More

J Am Podiatr Med Assoc 2021 Jul;111(4)

Background: Morton's neuroma is a common condition that routinely presents in podiatric practice. The aim of this study was to systematically synthesize the evidence relating to the effectiveness of a corticosteroid injection for Morton's neuroma.

Methods: Studies with a publication date of 1960 or later were eligible, and searches were performed within the Turning Research Into Practice database; the Cochrane Central Register of Controlled Trials; the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register; MEDLINE (Ovid); PubMed; Embase; Cumulative Index to Nursing and Allied Health Literature; and the gray literature. Read More

Skeletal Radiol 2022 Mar 14;51(3):581-586. Epub 2021 Jul 14.

Radiology, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Objectives: To assess the value of the divergence of toes on conventional radiographs of the foot for diagnosing Morton's neuroma.

Methods: This retrospective case-control study was approved by the local ethics committee. In 100 patients with MRI-proven Morton's neuroma 2/3 or 3/4 (study group) and 100 patients without (control group), conventional weight-bearing dorso-plantar view radiographs were evaluated for the subjective presence of interphalangeal divergence, called the Vulcan salute sign or V-sign, by two blinded, independent musculoskeletal radiologists. Read More

J Plast Reconstr Aesthet Surg 2021 Oct 12;74(10):2776-2820. Epub 2021 Jun 12.

Department of Plastic and Reconstructive Surgery, University Medical Center Utrecht, Netherlands.

Clin Orthop Surg 2021 Jun 22;13(2):266-277. Epub 2021 Apr 22.

Department of Orthopedic Surgery, Inje University Ilsan Paik Hospital, Goyang, Korea.

Backgroud: This review aimed to evaluate the effects of corticosteroid injections on Morton's neuroma using an algorithmic approach to assess the methodological quality of reported studies using a structured critical framework.

Methods: Several electronic databases were searched for articles published until April 2020 that evaluated the outcomes of corticosteroid injections in patients diagnosed with Morton's neuroma. Data search, extraction, analysis, and quality assessments were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Read More

JBJS Case Connect 2021 05 20;11(2). Epub 2021 May 20.

Orthopaedic Surgeon, Department of Orthopaedic Surgery, Hospital Dr. José de Almeida, Cascais, Portugal.

Case: A 65-year-old man presented with plantar foot pain associated with a mass in the first webspace. A Morton neuroma was considered the probable diagnosis. Despite nonoperative treatment the pain continued. Read More

Foot (Edinb) 2021 Jun 20;47:101808. Epub 2021 Apr 20.

Cirugíadelpie.net. Ciudad de Buenos Aires. Argentina.

Background: "Morton's Neuroma" is a frequent cause of chronic forefoot pain. It can affect general population, including athletes, and can lead to progressive foot pain and discomfort for daily life activities and sports.

Hypothesis/purpose: Our objective is to evaluate the long-term results in a series of 85 feet, operatively treated with minimally invasive interdigital approach for neurectomy. Read More

J Foot Ankle Surg 2021 Jul-Aug;60(4):866-869. Epub 2021 Mar 1.

Consultant, Department of Orthopaedics and Traumatology, North District Hospital, Sheung Shui, New Territories, Hong Kong. Electronic address:

Fibroma of tendon sheath is a rare benign tumor originating in the tendon or tendon sheath. It most commonly occurs in upper extremity and rarely presents in the foot. In this report, a case of fibroma of tendon sheath in the web space with Morton's neuroma-like symptoms was presented. Read More

J Am Podiatr Med Assoc 2020 Nov;110(6)

Background: This study describes the technique for decompression of the intermetatarsal nerve in Morton's neuroma by ultrasound-guided surgical resection of the transverse intermetatarsal ligament. This technique is based on the premise that Morton's neuroma is primarily a nerve entrapment disease. As with other ultrasound-guided procedures, we believe that this technique is less traumatic, allowing earlier return to normal activity, with less patient discomfort than with traditional surgical techniques. Read More

Med Clin North Am 2021 Jan 7;105(1):187-197. Epub 2020 Nov 7.

Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, 3701 Market Street, 7th Floor, Philadelphia, PA 19104, USA. Electronic address:

Primary care providers frequently care for complaints of the hands and feet. Here, the author describes the typical presentations of hand osteoarthritis, carpal tunnel syndrome, ganglion cysts, plantar fasciitis, onychomycosis, and Morton neuroma. Useful physical examination techniques are described. Read More

J Am Podiatr Med Assoc 2020 Sep;110(5)

Background: Morton's neuromas are abnormalities of the common digital nerve branch located between the lesser metatarsal heads. Historically, interdigital (Morton's) neuromas have been characterized as being most common in the third interspace and in females. The principal investigator observed Morton's neuromas commonly in the second and third interspaces in both sexes. Read More

Clin Radiol 2021 Mar 7;76(3):235.e15-235.e23. Epub 2020 Nov 7.

Department of Radiology, Nuffield Orthopaedic Centre, Oxford University Hospital NHS Trust, Oxford, UK.

Morton's neuroma is a commonly encountered cause of forefoot pain, which may limit weight-bearing activities and footwear choices. Although the aetiology and pathomechanism of this condition is controversial, the histological endpoint is well established as benign perineural fibrosis of a common plantar digital nerve, typically within the third intermetatarsal space. The diagnosis of Morton's neuroma is mainly based on characteristic symptoms and clinical findings, but may be confirmed by ultrasonography. Read More

Acta Reumatol Port 2020 Jul-Sep;45(3):220-222

Hospital Lusíadas Lisboa, Lisbon, Portugal.

Foot Ankle Int 2021 Apr 26;42(4):464-468. Epub 2020 Oct 26.

Trauma and Orthopaedic Surgery, University Hospitals of Leicester, Leicester, UK.

Background: The objective of this study was to evaluate the medium-term results of corticosteroid injections for Morton's neuroma.

Methods: This was a prospective follow-up study of a previous randomized controlled trial (RCT). Forty-five neuromas in 36 patients were injected with a single corticosteroid injection either with or without ultrasound guidance. Read More

Foot (Edinb) 2020 Dec 24;45:101723. Epub 2020 Jul 24.

Clinical and Anatomical pathologist, Shiraz University of Medical Sciences, Iran.

Morton's neuromas are benign lesions of the inter-digital nerves within the foot. They are most commonly found in the second and third webspace. Morton's neuroma of the first webspace is very rare. Read More

Swiss Med Wkly 2020 Sep 29;150:w20347. Epub 2020 Sep 29.

Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Switzerland.

Background: There is currently no consensus on the ideal approach for the operative treatment of Morton’s neuroma. The distal transverse plantar approach aims at optimal exposure without the scar complications associated with the longitudinal plantar approach. Long-term evaluation based on validated outcome instruments is lacking. Read More

BMJ 2020 10 9;371:m3704. Epub 2020 Oct 9.

Croydon University Hospital, London, UK.