14,672 results match your criteria Morton Neuroma


Essential oils and functional herbs for healthy aging.

Neural Regen Res 2019 Mar;14(3):441-445

School of Pharmacy and Applied Science, La Trobe Institute for Molecular Sciences, La Trobe University, Bendigo, Australia.

As total life expectancy increases, the prevalence of age-related diseases such as diabetes and Alzheimer's disease is also increasing. Many hypotheses about Alzheimer's disease have been developed, including cholinergic neuron damage, oxidative stress, and inflammation. Acetylcholine is a major neurotransmitter in the brain and cholinergic deficits leads to cognitive dysfunction and decline. Read More

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March 2019
1 Read

Incidence of severe critical events in paediatric anaesthesia in the United Kingdom: secondary analysis of the anaesthesia practice in children observational trial (APRICOT study).

Anaesthesia 2018 Dec 10. Epub 2018 Dec 10.

Department of Paediatric Anaesthesia and Pain Management, University of Glasgow, Glasgow, Scotland, UK.

The anaesthesia practice in children observational trial of 31,127 patients in 261 European hospitals revealed a high (5.2%) incidence of severe critical events in the peri-operative period and wide variability in practice. A sub-analysis of the UK data was undertaken to investigate differences compared with the non-UK cohort in the incidence and nature of peri-operative severe critical events and to attempt to identify areas for quality improvement. Read More

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December 2018

[Melanoma cutáneo. Etapificación ganglionar con base en la evidencia actual].

Gac Med Mex 2018 ;154(6):712-715

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Oncología, Ciudad de México, México.

Most patients with cutaneous melanoma present with clinical stage 1 at diagnosis, i.e., with no evidence of lymph node or systemic metastases. Read More

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January 2018

Silent voices: Transition experiences of family members caring for relatives with dementia.

Dementia (London) 2018 Dec 10:1471301218815037. Epub 2018 Dec 10.

Department of Nursing Science, Faculty of Health Sciences, Nelson Mandela University, South Africa.

Worldwide 46.8 million persons are living with dementia and many are requiring assistance with performing daily living or instrumental functions. It is often the task of family members to provide care for their relatives with dementia. Read More

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December 2018

The appropriateness of coronary investigation in myocardial injury and type 2 myocardial infarction (ACT-2): A randomized trial design.

Am Heart J 2018 Oct 25;208:11-20. Epub 2018 Oct 25.

Department of Cardiology, Flinders Medical Centre, Adelaide, Australia; College of Medicine and Public Health, Flinders University of South Australia, Adelaide, Australia. Electronic address:

Background: Elevated troponin level findings among patients presenting with suspected acute coronary syndrome (ACS) or another intercurrent illness undeniably identifies patients at increased risk of mortality. Whilst enhancing our capacity to discriminate risk, the use of high-sensitivity troponin assays frequently identifies patients with myocardial injury (i.e. Read More

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October 2018
4 Reads

Effects of folic acid food fortification scenarios on the folate intake of a multi-ethnic pregnant population.

Public Health Nutr 2018 Dec 6:1-12. Epub 2018 Dec 6.

2The Centre for Longitudinal Research - He Ara ki Mua, School of Population Health (building 730, level 3), Tamaki Campus,University of Auckland,261 Morrin Road, St Johns, Auckland 1072,New Zealand.

Objective: To simulate effects of different scenarios of folic acid fortification of food on dietary folate equivalents (DFE) intake in an ethnically diverse sample of pregnant women.

Design: A forty-four-item FFQ was used to evaluate dietary intake of the population. DFE intakes were estimated for different scenarios of food fortification with folic acid: (i) voluntary fortification; (ii) increased voluntary fortification; (iii) simulated bread mandatory fortification; and (iv) simulated grains-and-rice mandatory fortification. Read More

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December 2018

Consensus and controversies regarding follow-up after curative intent treatment of non-metastatic colorectal cancer: a synopsis of guidelines used in countries represented in ESCP.

Colorectal Dis 2018 Nov 30. Epub 2018 Nov 30.

Department of Surgery, Aarhus University Hospital, Aarhus, Denmark.

Aim: It is common clinical practice to follow patients for a period of years after curative intent treatment of non-metastatic colorectal cancer, but follow-up strategies vary widely. The aim of this systematic review was to provide an overview of recommendations in guidelines from ESCP member countries on this topic, with supporting evidence.

Methods: A systematic search of Medline, Embase and guidelines databases Tripdatabase, BMJ Best Practice and Guidelines International Network was performed. Read More

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November 2018
1 Read

Radiogenomic Predictors of Adverse Effects following Charged Particle Therapy.

Int J Part Ther 2018 21;5(1):103-113. Epub 2018 Sep 21.

Department of Radiation Oncology and Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Radiogenomics is the study of genomic factors that are associated with response to radiation therapy. In recent years, progress has been made toward identifying genetic risk factors linked with late radiation-induced adverse effects. These advances have been underpinned by the establishment of an international Radiogenomics Consortium with collaborative studies that expand cohort sizes to increase statistical power and efforts to improve methodologic approaches for radiogenomic research. Read More

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September 2018

K 3.1 Protein is Expressed as a Transmural Gradient across the Rat Left Ventricular Free Wall.

J Cardiovasc Electrophysiol 2018 Dec 5. Epub 2018 Dec 5.

School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds.

Introduction: K 3.1, also known as TASK-1, is a twin-pore acid-sensitive repolarizing K channel, responsible for a background potassium current that significantly contributes to setting the resting membrane potential of cardiac myocytes. Inhibition of I alters cardiac repolarization and is pro-arrhythmogenic. Read More

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December 2018
1 Read

Neurostimulation for Functional Neurological Disorder: Evaluating Longitudinal Neurophysiology.

Mov Disord Clin Pract 2018 Sep-Oct;5(5):561-563. Epub 2018 Oct 1.

The Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Division of Neurology University of Toronto Toronto Canada.

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October 2018
1 Read

Understanding, Impact, and Communication of "Off" Periods in Parkinson's Disease: A Scoping Review.

Mov Disord Clin Pract 2018 Sep-Oct;5(5):461-470. Epub 2018 Oct 9.

Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Research Toronto Western Hospital Toronto ON Canada.

Background: periods are a common and disabling symptom of Parkinson's disease. We reviewed published research on understanding, impact, and communication regarding periods to identify issues warranting further research.

Methods: We performed a scoping review, searching MEDLINE, EMBASE, Cochrane Library, CINAHL, and PsycINFO from 2006 to January 2018 for studies examining the impact of, understanding of, or communication about periods. Read More

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October 2018

Successful pallidotomy for post-hyperglycemic hemichorea-ballism.

Parkinsonism Relat Disord 2018 Nov 28. Epub 2018 Nov 28.

Division of Neurosurgery, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, M5T 2S8, Ontario, Canada. Electronic address:

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November 2018
3.972 Impact Factor

Land bridges in the Pleistocene contributed to flora assembly on the continental islands of South China: Insights from the evolutionary history of Quercus championii.

Mol Phylogenet Evol 2018 Dec 1;132:36-45. Epub 2018 Dec 1.

The Laboratory of Forestry Genetics, Central South University of Forestry and Technology, Changsha 410004, Hunan, China. Electronic address:

The South China Mainland (SCM) and its adjacent continental islands are a global biodiversity hotspot. However, how and when plants dispersed between SCM and Hainan/Taiwan Islands remains largely unknown. In this study, we used restriction site-associated DNA sequencing (RAD-seq) to identify the demographic dynamics and local adaptation of Quercus championii, a dominant forests tree distributed in SCM and Hainan/Taiwan Islands. Read More

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December 2018
2 Reads

Systematic review of the stage of innovation of biological mesh for complex or contaminated abdominal wall closure.

BJS Open 2018 Dec 14;2(6):371-380. Epub 2018 Jun 14.

College of Medical and Dental Sciences University of Birmingham Birmingham UK.

Background: Achieving stable closure of complex or contaminated abdominal wall incisions remains challenging. This study aimed to characterize the stage of innovation for biological mesh devices used during complex abdominal wall reconstruction and to evaluate the quality of current evidence.

Methods: A systematic review was performed of published and ongoing studies between January 2000 and September 2017. Read More

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December 2018
2 Reads

Less is more: a rationalization of daily labwork.

Can Med Educ J 2018 Nov 12;9(4):e135-e137. Epub 2018 Nov 12.

Department of Nephrology, Dalhousie University, Nova Scotia, Canada.

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November 2018
1 Read

An International Registry of Granulocyte Transfusions.

Transfus Med Hemother 2018 Oct 24;45(5):318-322. Epub 2018 Aug 24.

NHS Blood & Transplant/Oxford University Hospitals NHS Foundation Trust, and University of Oxford; Oxford, UK.

Introduction: Granulocyte transfusions are used to either treat or prevent life-threatening infections in neutropenic patients. Current evidence from clinical trials does not support or reject efficacy, nor guide practice.

Methods: A group of investigators have led the efforts to create an online registry to gather information on granulocyte transfusion practices from as broad a range of international settings. Read More

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October 2018
4 Reads

Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels.

Nat Commun 2018 11 29;9(1):5069. Epub 2018 Nov 29.

Beatson Institute for Cancer Research, Glasgow, G61 1BD, Scotland, UK.

Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercellular transfer of mutp53's invasive/migratory gain-of-function by increasing RCP-dependent integrin recycling in other tumour cells. This process depends on mutp53's ability to control production of the sialomucin, podocalyxin, and activity of the Rab35 GTPase which interacts with podocalyxin to influence its sorting to exosomes. Read More

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November 2018
1 Read

Squamous cell carcinoma of the anal canal.

Curr Probl Cancer 2018 Nov 23. Epub 2018 Nov 23.

Brigham and Women's Hospital, Boston, Massachusetts.

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November 2018
1 Read

Hospital doctors' experiences of caring for dying patients.

J R Coll Physicians Edinb 2018 Dec;48(4):299-303

Highland Hospice, Inverness, UK.

Background: The aim of this study was to examine, by means of a postal questionnaire, the experience of all grades of doctors caring for patients dying in an acute hospital in Scotland.

Method: A postal questionnaire was sent to 306 doctors working in inpatient medical and surgical specialties, emergency medicine, anaesthetics and intensive care medicine in an acute hospital.

Results: There was an overall 41% response rate (127/306). Read More

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December 2018
1 Read

Effects of biotic interactions on tropical tree performance depend on abiotic conditions.

Ecology 2018 Dec 28;99(12):2740-2750. Epub 2018 Nov 28.

Section for Ecoinformatics & Biodiversity, Department of Bioscience, Aarhus University, Ny Munkegade 114, Aarhus, 8000, Denmark.

Predicting biotic responses to environmental change requires understanding the joint effects of abiotic conditions and biotic interactions on community dynamics. One major challenge is to separate the potentially confounding effects of abiotic environmental variation and local biotic interactions on individual performance. The stress gradient hypothesis (SGH) addresses this issue directly by predicting that the effects of biotic interactions on performance become more positive as the abiotic environment becomes more stressful. Read More

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December 2018
1 Read

Recent Advances in X-Ray Hydroxl Radical Footprinting at the Advanced Light Source Synchrotron.

Protein Pept Lett 2018 Nov 28. Epub 2018 Nov 28.

Molecular Biology and Integrated Bioimaging Division - Lawrence Berkeley National Laboratory Berkeley, CA. United States.

Efforts in the field of synchrotron footprinting are progressing rapidly, with two major footprinting centers in the United States, one on the east coast at the National Synchrotron Light Source II, and one on the west coast at the Advanced Light Source. This article describes recent technical advances in the technique at the Advanced Light Source, and describes the types of biological problems that can be addressed using the new methods and instrumentation. Read More

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November 2018
1 Read

Catheter Ablation of Post-Infarct VT: Mechanisms, Strategies and Outcomes.

Heart Lung Circ 2018 Oct 15. Epub 2018 Oct 15.

Centre for Heart Rhythm Disorders, University of Adelaide and the Royal Adelaide Hospital, Adelaide, SA, Australia.

Ventricular arrhythmias are one of the leading causes of death in patients with a prior myocardial infarction. Implantable cardioverter-defibrillators (ICDs) are very effective in the prevention of sudden cardiac death but the risk of recurrence remains an issue since defibrillation does not alter the underlying substrate. Recurrent ICD shocks are distressing and are associated with an increase in mortality. Read More

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October 2018
1 Read
1.170 Impact Factor

Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function.

Dis Model Mech 2018 Nov 26. Epub 2018 Nov 26.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK

Isocitrate dehydrogenase (IDH) is an enzyme required for the production of α-ketoglutarate from isocitrate. IDH3 generates the NADH used in the mitochondria for ATP production, and is a tetramer made up of two α, a β and a γ subunit. Loss of function and missense mutations in both and have previously been implicated in families exhibiting retinal degeneration. Read More

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November 2018
2 Reads

Validation of epigenetic markers to identify colitis associated cancer: Results of module 1 of the ENDCAP-C study.

EBioMedicine 2018 Nov 22. Epub 2018 Nov 22.

Institute of Cancer & Genomic Science, University of Birmingham, UK.

Background: Chronic inflammation caused by ulcerative colitis (UC) causes a pro-neoplastic drive in the inflamed colon, leading to a markedly greater risk of invasive malignancy compared to the general population. Despite surveillance protocols, 50% of cases proceed to cancer before neoplasia is detected. The Enhanced Neoplasia Detection and Cancer Prevention in Chronic Colitis (ENDCaP-C) trial is an observational multi-centre test accuracy study to ascertain the role of molecular markers in improving the detection of dysplasia. Read More

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November 2018
2 Reads

Diagnostic biomarkers for Parkinson's disease: focus on α-synuclein in cerebrospinal fluid.

Authors:
Lorraine V Kalia

Parkinsonism Relat Disord 2018 Nov 15. Epub 2018 Nov 15.

Division of Neurology, Department of Medicine and Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto; Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Division of Neurology, Department of Medicine and Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. Electronic address:

Diagnostic biomarkers are measures that detect or confirm the presence of a disease or identify individuals with a subtype of the disease. For Parkinson's disease, unlike other neurodegenerative diseases such as Alzheimer's disease and Creutzfeldt-Jakob disease, diagnostic biomarkers remain elusive as none are yet available or approved for clinical use. A biomarker to diagnose early or prodromal Parkinson's disease with high accuracy would significantly enhance clinical practice as well as advance clinical therapeutic trials. Read More

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November 2018
4 Reads

Effects of life history and reproduction on recruitment time lags in reintroductions of rare plants.

Conserv Biol 2018 Nov 21. Epub 2018 Nov 21.

Fairchild Tropical Botanic Garden, 10901 Old Cutler Road, Miami, FL 33156, U.S.A.

Reintroductions are important components of conservation and recovery programs with rare plant species, but their long-term success rates are poorly understood. Previous reviews of plant reintroductions focused on short-term (e.g. Read More

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November 2018
2 Reads

AGMT3-D: A software for 3-D landmarks-based geometric morphometric shape analysis of archaeological artifacts.

PLoS One 2018 20;13(11):e0207890. Epub 2018 Nov 20.

Institute of Archaeology, Mount Scopus, The Hebrew University of Jerusalem, Jerusalem, Israel.

We present here a newly developed software package named Artifact GeoMorph Toolbox 3-D (AGMT3-D). It is intended to provide archaeologists with a simple and easy-to-use tool for performing 3-D landmarks-based geometric morphometric shape analysis on 3-D digital models of archaeological artifacts. It requires no prior knowledge of programming or proficiency in statistics. Read More

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November 2018
4 Reads

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer.

Cell 2018 Nov 25;175(5):1244-1258.e26. Epub 2018 Oct 25.

Fels Institute for Cancer Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA. Electronic address:

Cyclin-dependent kinase 9 (CDK9) promotes transcriptional elongation through RNAPII pause release. We now report that CDK9 is also essential for maintaining gene silencing at heterochromatic loci. Through a live cell drug screen with genetic confirmation, we discovered that CDK9 inhibition reactivates epigenetically silenced genes in cancer, leading to restored tumor suppressor gene expression, cell differentiation, and activation of endogenous retrovirus genes. Read More

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November 2018
14 Reads

Association of Bariatric Surgery and National Medication Use.

J Am Coll Surg 2018 Nov 17. Epub 2018 Nov 17.

University of California, Irvine, CA.

Background: Bariatric surgical procedures are an effective and enduring treatment for severe obesity. In addition to improvements in health status, bariatric operations have been noted to potentially decrease postoperative healthcare costs, particularly medication use.

Study Design: We performed a longitudinal analysis of 2007-2012 claims data comparing a bariatric surgical cohort with a propensity-matched nonsurgical control group during a 5-year time period. Read More

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November 2018
5 Reads

Focused ultrasound thalamotomy location determines clinical benefits in patients with essential tremor.

Brain 2018 Dec;141(12):3405-3414

University Health Network, Toronto, ON, Canada.

Magnetic resonance guided focused ultrasound (MRgFUS) thalamotomy is a novel and minimally invasive ablative treatment for essential tremor. The size and location of therapeutic lesions producing the optimal clinical benefits while minimizing adverse effects are not known. We examined these relationships in patients with essential tremor undergoing MRgFUS. Read More

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December 2018
6 Reads
9.196 Impact Factor

An apple a day? Assessing gardeners' lead exposure in urban agriculture sites to improve the derivation of soil assessment criteria.

Environ Int 2018 Nov 15. Epub 2018 Nov 15.

Institute of Health and Society, Medical Faculty, Newcastle University, Newcastle upon Tyne NE2 4AX, UK.

Globally, many of our urban agriculture sites (UAS) contain high levels of lead (Pb), a contaminant of toxicological concern to humans. To improve the derivation of soil assessment criteria at UAS, and avoid inappropriate closure of these valuable community spaces, we sampled nearly 280 paired soil and crop samples across 31 UAS gardens. This sampling was coupled with an exposure and food frequency questionnaire and participants blood Pb levels (BLL), (43 gardeners and 29 non-gardening neighbours). Read More

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November 2018
3 Reads

The Focused Musculoskeletal Factory.

Rheum Dis Clin North Am 2019 Feb;45(1):53-66

Illinois Bone and Joint Institute, 9000 Waukegan Road, Morton Grove, IL 60053, USA. Electronic address:

Rheumatology has evolved rapidly over the past 20 years. The availability of numerous treatment interventions has dramatically altered patient outcomes and revitalized the specialty. At the same time, the economics of medical practice is challenging the practicing rheumatologist to seek more efficient and more attractive models of care delivery. Read More

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February 2019
1 Read

Partitioning mortality into growth-dependent and growth-independent hazards across 203 tropical tree species.

Proc Natl Acad Sci U S A 2018 Dec 16;115(49):12459-12464. Epub 2018 Nov 16.

Evolution and Ecology Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.

Tree death drives population dynamics, nutrient cycling, and evolution within plant communities. Mortality variation across species is thought to be influenced by different factors relative to variation within species. The unified model provided here separates mortality rates into growth-dependent and growth-independent hazards. Read More

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December 2018
1 Read

Clinical and imaging characteristics of posterior column ataxia with retinitis pigmentosa with a specific FLVCR1 mutation.

Ophthalmic Genet 2018 Dec 16;39(6):735-740. Epub 2018 Nov 16.

a Department of Pediatric Ophthalmology, Strabismus, and Adult Motility , Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center , Pittsburgh , Pennsylvania , USA.

Background: Posterior column ataxia retinitis pigmentosa (PCARP) with feline leukemia virus subgroup C cellular receptor 1 (FLVCR1) gene mutation is a rare disorder with significant ophthalmic features.

Materials And Methods: We conducted a retrospective case series study of patients diagnosed with PCARP and genetic testing positive for FLVCR1 mutation between 1 January 2015 and 1 October 2017 at the Children's Hospital of Pittsburgh. Clinical charts, visual fields, fundus autofluorescence, and spectral-domain optical coherence tomography (SD-OCT) were reviewed. Read More

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December 2018
10 Reads

NCCN Guidelines Insights: Cancer-Associated Venous Thromboembolic Disease, Version 2.2018.

J Natl Compr Canc Netw 2018 Nov;16(11):1289-1303

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Moffitt Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Mayo Clinic Cancer Center; University of Michigan Rogel Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Dana-Farber/Brigham and Women's Cancer Center; National Blood Clot Alliance; Massachusetts General Hospital Cancer Center; The University of Texas MD Anderson Cancer Center; Fred & Pamela Buffett Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; University of Colorado Cancer Center; Fox Chase Cancer Center; Vanderbilt-Ingram Cancer Center; Duke Cancer Institute; Roswell Park Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; UC San Diego Moores Cancer Center; City of Hope National Medical Center; Huntsman Cancer Institute at the University of Utah; Memorial Sloan Kettering Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; University of Wisconsin Carbone Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; and National Comprehensive Cancer Network.

Venous thromboembolism (VTE) is common in patients with cancer and increases morbidity and mortality. VTE prevention and treatment are more complex in patients with cancer. The NCCN Guidelines for Cancer-Associated Venous Thromboembolic Disease outline strategies for treatment and prevention of VTE in adult patients diagnosed with cancer or in whom cancer is clinically suspected. Read More

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November 2018

Symptom severity and quality of life in patients with atrial fibrillation: Psychological function outweighs clinical predictors.

Int J Cardiol 2018 Nov 2. Epub 2018 Nov 2.

The Department of Cardiology, Royal Melbourne Hospital, Melbourne, Australia; The Department of Medicine, University of Melbourne, Melbourne, Australia.

Background: The key drivers of symptom severity and health-related quality of life (hr-QOL) in patients with atrial fibrillation (AF) remain unclear. We aimed to determine the relative contribution to symptom severity and hr-QOL of clinical factors including left ventricular (LV) diastolic function and ventricular rate control during AF and of psychological functioning.

Methods: Seventy-eight consecutive patients with symptomatic AF and preserved LV systolic function underwent detailed evaluation of i) AF symptom severity and hr-QOL; ii) clinical factors including left ventricular (LV) diastolic function, AF burden, and ventricular rate during AF and iii) state and trait aspects of psychological functioning. Read More

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November 2018
3 Reads

How can we evaluate the cost-effectiveness of health system strengthening? A typology and illustrations.

Soc Sci Med 2018 Nov 3;220:141-149. Epub 2018 Nov 3.

Imperial College Business School, Imperial College London, South Kensington Campus, London, SW7 2AZ, United Kingdom. Electronic address:

Health interventions often depend on a complex system of human and capital infrastructure that is shared with other interventions, in the form of service delivery platforms, such as healthcare facilities, hospitals, or community services. Most forms of health system strengthening seek to improve the efficiency or effectiveness of such delivery platforms. This paper presents a typology of ways in which health system strengthening can improve the economic efficiency of health services. Read More

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November 2018
3 Reads

Case Study: Assessment of Energy Expenditure of a Professional Goalkeeper From the English Premier League Using the Doubly Labeled Water Method.

Int J Sports Physiol Perform 2018 Nov 14:1-13. Epub 2018 Nov 14.

1 Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.

Purpose:: To better understand the energy and carbohydrate (CHO) requirements of a professional goalkeeper (GK) in elite soccer, we quantified physical loading, energy expenditure (EE) and energy intake (EI) during a two game per week in-season micro-cycle.

Methods:: Daily training and match loads were assessed in a professional GK |(age, 26 years; height, 191 cm; body mass, 86.1 kg) from the English Premier League using global positioning systems (GPS) and ProZone, respectively. Read More

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November 2018
2 Reads

Ultra-high-frequency deep brain stimulation at 10,000 Hz improves motor function.

Mov Disord 2018 Nov 13. Epub 2018 Nov 13.

Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

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November 2018
5.680 Impact Factor

Parkinsonism due to A53E α-synuclein gene mutation: Clinical, genetic, epigenetic, and biochemical features.

Mov Disord 2018 Nov 13. Epub 2018 Nov 13.

Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic, Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.

Background: SNCA mutations cause autosomal dominant parkinsonism and inform our understanding of the molecular underpinnings of synucleinopathies. The most recently identified mutation, p.Ala53Glu (A53E), has only been observed in Finland. Read More

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November 2018
10 Reads

How differing methods of ascribing ethnicity and socio-economic status affect risk estimates for hospitalisation with infectious disease.

Epidemiol Infect 2018 Nov 13:1-9. Epub 2018 Nov 13.

Growing Up in New Zealand,Centre for Longitudinal Research, University of Auckland,Private Bag 92019, Auckland,New Zealand.

Significant ethnic and socio-economic disparities exist in infectious diseases (IDs) rates in New Zealand, so accurate measures of these characteristics are required. This study compared methods of ascribing ethnicity and socio-economic status. Children in the Growing Up in New Zealand longitudinal cohort were ascribed to self-prioritised, total response and single-combined ethnic groups. Read More

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November 2018
4 Reads

To Protect and to Preserve: Novel Preservation Strategies for Extracellular Vesicles.

Front Pharmacol 2018 29;9:1199. Epub 2018 Oct 29.

The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.

Extracellular vesicles (EVs)-based therapeutics are based on the premise that EVs shed by stem cells exert similar therapeutic effects and these have been proposed as an alternative to cell therapies. EV-mediated delivery is an effective and efficient system of cell-to-cell communication which can confer therapeutic benefits to their target cells. EVs have been shown to promote tissue repair and regeneration in various animal models such as, wound healing, cardiac ischemia, diabetes, lung fibrosis, kidney injury, and many others. Read More

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October 2018

The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease.

Hum Immunol 2018 Nov 9. Epub 2018 Nov 9.

Translational Research Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia; Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.

The oxytocinase subfamily of M1 aminopeptidases plays an important role in processing and trimming of peptides for presentation on major histocompatibility (MHC) Class I molecules. Several large-scale genomic studies have identified association of members of this family of enzymes, most notably ERAP1 and ERAP2, with immune-mediated diseases including ankylosing spondylitis, psoriasis and birdshot chorioretinopathy. Much is now known about the genetics of these enzymes and how genetic variants alter their function, but how these variants contribute to disease remains largely unresolved. Read More

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November 2018
4 Reads

Patterns and predictors of fleshy fruit phenology at five international botanical gardens.

Am J Bot 2018 Nov 12;105(11):1824-1834. Epub 2018 Nov 12.

Department of Geography, University of British Columbia, Vancouver, British Columbia, V6T 1Z2, Canada.

Premise Of The Study: To improve our understanding of the patterns and drivers of fleshy fruit phenology, we examined the sequence, patterns across years and locations, and drivers of fruiting times at five botanical gardens on three continents.

Methods: We monitored four stages of fruit phenology for 406 temperate, fleshy-fruited, woody plant species in 2014 and 2015.

Key Results: Across all gardens, ripe fruits were present from May to March of the following year, with peak fruiting durations ranging from under 1 week to over 150 days. Read More

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November 2018
1 Read

Economic and epidemiological impact of dengue illness over 16 years from a public health system perspective in Brazil to inform future health policies including the adoption of a dengue vaccine.

Expert Rev Vaccines 2018 Dec;17(12):1123-1133

a Programa de Pós-graduação em Medicamentos e Assistência Farmacêutica, Faculdade de Farmácia , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.

Introduction: Dengue is a serious global health problem endemic in Brazil. Consequently, our aim was to measure the costs and disease burden of symptomatic dengue infections in Brazil from the perspective of the Brazilian Public Health System (SUS) between 2000 and 2015, using Brazilian public health system databases. Specific age group incidence estimates were used to calculate the disability-adjusted life years (DALYs) to gain a better understanding of the disease burden. Read More

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December 2018
6 Reads
4.210 Impact Factor

Increased SOD2 in the diaphragm contributes to exercise-induced protection against ventilator-induced diaphragm dysfunction.

Redox Biol 2018 Oct 21;20:402-413. Epub 2018 Oct 21.

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United States. Electronic address:

Mechanical ventilation (MV) is a life-saving intervention for many critically ill patients. Unfortunately, prolonged MV results in rapid diaphragmatic atrophy and contractile dysfunction, collectively termed ventilator-induced diaphragm dysfunction (VIDD). Recent evidence reveals that endurance exercise training, performed prior to MV, protects the diaphragm against VIDD. Read More

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October 2018
7 Reads