Search our Database of Scientific Publications and Authors

I’m looking for a

    4929 results match your criteria Morphea

    1 OF 99

    Post-Irradiation Morphea in Breast Cancer: An Uncommon Differential Diagnosis to Keep in Mind.
    World J Oncol 2010 Dec 1;1(6):250-251. Epub 2011 Jan 1.
    Pathology Service, Complejo Hosp. A. Marcide, Ferrol, A Coruna, Spain.
    Breast cancer is the most common cancer in women of developed countries. Early stage diagnosis is followed, in many cases, of conservative surgery and local radiotherapy. This treatment reduces loco-regional recurrences but may be accompanied by local complications. Read More

    Localized Scleroderma, Systemic Sclerosis and Cardiovascular Risk: A Danish Nationwide Cohort Study.
    Acta Derm Venereol 2017 Nov 14. Epub 2017 Nov 14.
    Department of Dermatology and Allergy, Herlev and Gentofte University Hospital, University of Copenhagen, Kildegaardsvej 28, DK-2900 Hellerup, Denmark.
    Recent findings indicate that patients with systemic sclerosis have an increased risk of cardiovascular disease. To determine whether patients with systemic sclerosis or localized scleroderma are at increased risk of cardiovascular disease, a cohort study of the entire Danish population aged ≥ 18 and ≤ 100 years was conducted, followed from 1997 to 2011 by individual-level linkage of nationwide registries. Multivariable adjusted Cox regression models were used to estimate the hazard ratios (HRs) for a composite cardiovascular disease endpoint. Read More

    Orthopedic complications of linear morphea: Implications for early interdisciplinary care.
    Pediatr Dermatol 2017 Nov 9. Epub 2017 Nov 9.
    Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
    Linear morphea of the limb primarily affects children, and extracutaneous manifestations are common. Orthopedic surgeons are often essential in the care of patients with linear morphea, yet there are few reports outlining specific orthopedic complications in this population. We sought to improve the understanding of orthopedic complications in linear morphea of the limb. Read More

    Post-irradiation morphoea of the breast: a case report and review of the literature.
    Histopathology 2017 Aug 14. Epub 2017 Aug 14.
    Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
    We describe a 44-year-old female with triple-negative breast cancer who developed skin erythaema, sclerosis and contracture of her entire right breast 15 months after completion of post-lumpectomy chemotherapy and radiotherapy, consistent with post-irradiation morphoea (PIM). PIM is a rare complication of breast irradiation that impairs a patient's quality of life. PIM is located usually at the radiation port or in the surrounding tissue. Read More

    Granuloma Annulare and Morphea: Correlation with Borrelia burgdorferi Infections and Chlamydia-related Bacteria.
    Acta Derm Venereol 2017 Nov 7. Epub 2017 Nov 7.
    Department of Dermatology, Allergology and Venereal Diseases, University of Helsinki and Center of Inflammation, Helsinki University Central Hospital, FIN-00029 Helsinki, Finland.
    A retrospective study of 109 skin biopsies with granuloma annulare (GA) or morphea histology from patients with suspected tick bite was performed. Biopsies were tested for cutaneous Borrelia burgdorferi DNA using PCR. The same biopsies were analysed for tick-borne novel agents, Chlamydia-related bacteria (members of the Chlamydiales order), using a PCR-based method. Read More

    Surgical Management of Localized Scleroderma.
    Arch Craniofac Surg 2017 Sep 26;18(3):166-171. Epub 2017 Sep 26.
    Department of Plastic and Reconstructive Surgery, Hanyang University College of Medicine, Seoul, Korea.
    Background: Localized scleroderma is characterized by a thickening of the skin from excessive collagen deposits. It is not a fatal disease, but quality of life can be adversely affected due to changes in skin appearance, joint contractures, and, rarely, serious deformities of the face and extremities. We present six cases of localized scleroderma in face from our surgical practice. Read More

    Early-Life Gut Dysbiosis: A Driver of Later-Life Fibrosis?
    J Invest Dermatol 2017 Nov;137(11):2253-2255
    Department of Medicine, Northwestern University, Chicago, Illinois, USA. Electronic address:
    Using a novel mouse model of scleroderma induced by immunization with topoisomerase-I peptide-loaded dendritic cells, Mehta et al. found that early-life antibiotic exposure resulted in increased later-life fibrosis in the skin and lungs. These observations advance the novel concept that gut microbiome alterations caused by early-life exposures may contribute to scleroderma pathogenesis, and warrant in-depth characterization and validation in complementary disease models. Read More

    Swallowing difficulties with medication intake assessed with a novel self-report questionnaire in patients with systemic sclerosis - a cross-sectional population study.
    Patient Prefer Adherence 2017 28;11:1687-1699. Epub 2017 Sep 28.
    Pharmaceutical Care Research Group, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
    Objectives: To assess subjective swallowing difficulties (SD) with medication intake and their practical consequences in patients suffering from systemic sclerosis (SSc) with a novel self-report questionnaire.

    Design And Setting: Based on a systematic literature review, we developed a self-report questionnaire and got it approved by an expert panel. Subsequently, we sent the questionnaire by post mail to SSc patients of the European Center for the Rehabilitation of Scleroderma Rheinfelden, Switzerland. Read More

    Tocilizumab in two children with pansclerotic morphoea: a hopeful therapy for refractory cases?
    Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 106(4):211-213. Epub 2017 Sep 29.
    Paediatric Rheumatology Unit, Department for the Woman and Child Health, University of Padova, Italy.
    Pansclerotic morphoea (PM) is a subtype of juvenile localised scleroderma characterised by severe course with generalised full-thickness skin involvement and possible growth and functional impairment. PM treatment comprises a combination of immunosuppressive agents such as corticosteroids, methotrexate, mycophenolate mofetil, PUVA and antithymocyte globulin and biological agents used in off-label. A possible role of IL-6 in the regulation of firoblast differentiation and stimulation of collagen synthesis has been suggested and in patients with systemic sclerosis (SSc) the treatment with tocilizumab (TCZ) was associated to improvement of skin thickness and joint motion. Read More

    UVA1 a promising approach for scleroderma.
    Am J Transl Res 2017 15;9(9):4280-4287. Epub 2017 Sep 15.
    Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of MedicineShanghai, China.
    Scleroderma is a complex connective tissue disease characterized by fibrosis, vasculopathy, and immune system dysfunction. The heterogeneity of disease presentation and poorly understood etiology has made the management of scleroderma difficult. The available treatment options like immunosuppressive agents are associated with potentially hazardous side effects and physiotherapy, which to a certain degree helps to minimize the loss of function in digits and limbs, has only limited success. Read More

    Pansclerotic morphea associated with hypohidrosis and anti-M3 muscarinic acetylcholine receptor antibodies.
    Br J Dermatol 2017 Oct 4. Epub 2017 Oct 4.
    Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
    A man in his 50s was referred to our hospital due to a 3-month history of extensive hypohidrosis that he first realized in his upper trunk. He subsequently noticed tenseness of the skin on the hypohidrotic areas. He had a medical history of hyperlipidemia, duodenum ulcer and obsessive-compulsive disorder, but had not received drugs known to induce sclerosis or hypohidrosis. Read More

    Scleroderma keratinocytes promote fibroblast activation independent of transforming growth factor beta.
    Rheumatology (Oxford) 2017 Nov;56(11):1970-1981
    Department of Internal Medicine, Division of Rheumatology.
    Objectives: SSc is a devastating disease that results in fibrosis of the skin and other organs. Fibroblasts are a key driver of the fibrotic process through deposition of extracellular matrix. The mechanisms by which fibroblasts are induced to become pro-fibrotic remain unclear. Read More

    Fibrous Arthropathy Associated With Morphea: A New Cause of Diffuse Acquired Joint Contractures.
    Pediatrics 2017 Oct;140(4)
    Unité d'Immuno-Hématologie et Rhumatologie Pédiatrique, Hôpital Necker Enfants Malades, Institut IMAGINE, Assistance Publique - Hopitaux de Paris, Paris, France
    Etiologies for childhood-onset diffuse joint contractures encompass a large group of inherited disorders and acquired diseases, in particular a subtype of juvenile idiopathic arthritis called "dry polyarthritis," dermatomyositis, and systemic sclerosis. We report on 2 boys, aged 5 and 8 years, who developed acquired symmetric painless joint contractures preceding the development of superficial plaques of morphea by 7 to 13 months. There was no other clinical involvement, biological inflammation, or autoantibodies. Read More

    Morphea in Middle Anatolia, Turkey: a 5-year single-center experience.
    Postepy Dermatol Alergol 2017 Aug 1;34(4):334-338. Epub 2017 Aug 1.
    Department of Dermatology and Venereology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
    Introduction: Morphea, also referred to as localized scleroderma, is a rare fibrosing skin disorder of undetermined cause.

    Aim: We report our single-center experience with morphea.

    Material And Methods: The study included 53 patients who were diagnosed with morphea by histopathology in our department between 2010 and 2015. Read More

    [Current Therapies in Superficial Malignant Tumors].
    Klin Monbl Augenheilkd 2017 Sep 12. Epub 2017 Sep 12.
    Zentrum für Augenheilkunde, Universitätsklinikum Essen, Essen.
    This article is a review of diagnostic and therapeutic possibilities in common epibulbar malignant tumors, such as basal cell carcinoma, conjunctival lymphoma, squamous cell carcinoma and conjunctival melanoma. Most importantly, for every tumor patient there is a detailed anamnesis, split lamp examination and photo documentation. Further regular controls after therapy are required due to the risk of recurrences. Read More

    Pathophysiological Mechanisms in Sclerosing Skin Diseases.
    Front Med (Lausanne) 2017 18;4:120. Epub 2017 Aug 18.
    Department of Dermatology, University of Cologne, Cologne, Germany.
    Sclerosing skin diseases represent a large number of distinct disease entities, which include systemic sclerosis, localized scleroderma, and scleredema adultorum. These pathologies have a common clinical appearance and share histological features. However, the specific interplay between cytokines and growth factors, which activate different mesenchymal cell populations and production of different extracellular matrix components, determines the biomechanical properties of the skin and the clinical features of each disease. Read More

    Clinicopathologic and immunophenotypic features of eosinophilic fasciitis and morphea profunda: A comparative study of 27 cases.
    J Am Acad Dermatol 2017 Aug 30. Epub 2017 Aug 30.
    Department of Dermatology, Mayo School of Graduate Medical Education, Mayo Clinic, Rochester, Minnesota; Department of Laboratory Medicine and Pathology, Mayo School of Graduate Medical Education, Mayo Clinic, Rochester, Minnesota. Electronic address:
    Background: Eosinophilic fasciitis (EF) and morphea profunda (MP) are inflammatory and sclerosing disorders of the subcutis that can exhibit clinical and pathologic presentations that overlap.

    Objective: To identify clinicopathologic features that can be used to distinguish EF from MP.

    Methods: We performed a retrospective review of 16 patients with EF and 11 patients with MP. Read More

    European Dermatology Forum S1-guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 1: localized scleroderma, systemic sclerosis and overlap syndromes.
    J Eur Acad Dermatol Venereol 2017 Sep 9;31(9):1401-1424. Epub 2017 Aug 9.
    Department of Dermatology and Venereology, University Hospital of Cologne, Cologne, Germany.
    The term 'sclerosing diseases of the skin' comprises specific dermatological entities, which have fibrotic changes of the skin in common. These diseases mostly manifest in different clinical subtypes according to cutaneous and extracutaneous involvement and can sometimes be difficult to distinguish from each other. The present guideline focuses on characteristic clinical and histopathological features, diagnostic scores and the serum autoantibodies most useful for differential diagnosis. Read More

    Interstitial Granulomatous Dermatitis (IGD).
    Open Access Maced J Med Sci 2017 Jul 21;5(4):543-544. Epub 2017 Jul 21.
    Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior, and Onkoderma Polyclinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
    We report the case of a 42 years old male patient suffering from skin changes, which appeared in the last 7-8 years. Two biopsies were performed during the evolution of the lesion. Both showed similar findings that consisted in a busy dermis with interstitial, superficial and deep infiltrates of lymphocytes and histiocytes dispersed among collagen bundles, with variable numbers of neutrophils scattered throughout. Read More

    Lymphocytic hidradenitis: A distinctive histopathological finding of annular erythema of Sjögren syndrome.
    Australas J Dermatol 2017 Aug 3. Epub 2017 Aug 3.
    College of Medicine, Chang Gung University, Taoyuan, Taiwan.
    Background/objectives: Lymphocytic hidradenitis is a non-specific histopathological feature observed in many dermatoses such as lupus erythematosus, morphea or scleroderma. When it occurs it is usually accompanied by the other distinctive histological features of those conditions. Isolated lymphocytic hidradenitis is uncommon and its clinical features and associated underlying medical conditions are still undetermined. Read More

    [Extensive connective tissue nevus in children].
    Ann Dermatol Venereol 2017 Nov 29;144(11):700-704. Epub 2017 Jul 29.
    Service de dermatologie, CHU de Caen, avenue de la Côte-de-Nacre, CS 30001, 14033 Caen cedex 9, France.
    Background: Connective tissue nevus (CTN) is a rare condition of the extracellular matrix components that generally presents as papulae of normal skin colour. This condition may be syndromic or sporadic.

    Patients And Methods: We report herein two isolated cases of extensive and infiltrative CTN in children at risk for subsequent joint stiffening. Read More

    Decreased Hepatitis B vaccine response in pediatric patients with atopic dermatitis, psoriasis, and morphea.
    Vaccine 2017 Aug 20;35(35 Pt B):4499-4500. Epub 2017 Jul 20.
    Section of Pediatric Dermatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States.
    Multiple groups of patients have been recognized for having high rates of non-responders to the Hepatitis B vaccine including those with HIV, inflammatory bowel disease, and chronic kidney disease. These patients are at increased risk for infection due to both the nature of their underlying diseases and the immunosuppressive drugs they are commonly prescribed. Identification of groups with high non-response rates is essential in order to establish vaccination guidelines and prevent serious infections in already susceptible patients. Read More

    Long-term outcome of eosinophilic fasciitis: A cross-sectional evaluation of 35 patients.
    J Am Acad Dermatol 2017 Sep 19;77(3):512-517.e5. Epub 2017 Jul 19.
    Department of Dermatology, Radboud University, Nijmegen, The Netherlands; Radboud University Medical Centre, Radboud University, Nijmegen, The Netherlands.
    Background: Eosinophilic fasciitis (EF) is a connective tissue disease with an unknown long-term course.

    Objective: To evaluate presence and determinants of residual disease damage in patients with EF after long-term follow-up.

    Methods: Patients with biopsy-proven EF were included for this cross-sectional study. Read More

    Cutaneous Manifestations of Scleroderma and Scleroderma-Like Disorders: a Comprehensive Review.
    Clin Rev Allergy Immunol 2017 Jul 16. Epub 2017 Jul 16.
    Section of Dermatology, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
    Scleroderma refers to an autoimmune connective tissue fibrosing disease, including three different subsets: localized scleroderma, limited cutaneous systemic sclerosis, and diffuse cutaneous systemic sclerosis with divergent patterns of organ involvement, autoantibody profiles, management, and prognostic implications. Although systemic sclerosis is considered the disease prototype that causes cutaneous sclerosis, there are many other conditions that can mimic and be confused with SSc. They can be classified into immune-mediated/inflammatory, immune-mediated/inflammatory with abnormal deposit (mucinoses), genetic, drug-induced and toxic, metabolic, panniculitis/vascular, and (para)neoplastic disorders according to clinico-pathological and pathogenetic correlations. Read More

    Large Left Ventricular Aneurysm and Multifocal Myocardial Involvement in a Patient With Systemic Sclerosis.
    Can J Cardiol 2017 Jul 29;33(7):950.e5-950.e6. Epub 2017 Mar 29.
    Cardiovascular Department, Santa Corona Hospital, Pietra Ligure (SV), Italy.
    A 43-year-old man with systemic sclerosis and chest pain had negative T waves in precordial electrocardiographic leads. The echocardiogram showed a large left ventricular apical accessory chamber. The coronary arteries were normal. Read More

    The impact of high-dose narrowband ultraviolet A1 on dermal thickness, collagen and matrix-metalloproteinases in animal model of scleroderma.
    J Photochem Photobiol B 2017 Aug 21;173:448-455. Epub 2017 Jun 21.
    State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08406 Vilnius, Lithuania; Vilnius University, Faculty of Medicine, Center of Rheumatology, Santariskiu St. 2, LT-08661 Vilnius, Lithuania. Electronic address:
    Objective: The main purpose of the present study was to define the impact of high-dose of 365±5nm ultraviolet A1 (UVA1) on dermal fibrosis in the pre-established, bleomycin-induced mouse model of scleroderma.

    Methods: DBA/2 strain mice with the pre-established, bleomycin-induced scleroderma were irradiated with cumulative UVA1 dose of 1200J/cm(2) and in parallel were challenged with prolonged administration of bleomycin. Non-treated groups served as the control. Read More

    Deep Proteome Profiling Reveals Common Prevalence of MZB1-Positive Plasma B Cells in Human Lung and Skin Fibrosis.
    Am J Respir Crit Care Med 2017 Nov;196(10):1298-1310
    1 Comprehensive Pneumology Center, German Research Center for Environmental Health, Munich, Germany.
    Rationale: Analyzing the molecular heterogeneity of different forms of organ fibrosis may reveal common and specific factors and thus identify potential future therapeutic targets.

    Objectives: We sought to use proteome-wide profiling of human tissue fibrosis to (1) identify common and specific signatures across end-stage interstitial lung disease (ILD) cases, (2) characterize ILD subgroups in an unbiased fashion, and (3) identify common and specific features of lung and skin fibrosis.

    Methods: We collected samples of ILD tissue (n = 45) and healthy donor control samples (n = 10), as well as fibrotic skin lesions from localized scleroderma and uninvolved skin (n = 6). Read More

    Optimization of a murine and human tissue model to recapitulate dermal and pulmonary features of systemic sclerosis.
    PLoS One 2017 26;12(6):e0179917. Epub 2017 Jun 26.
    Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America.
    The murine bleomycin (BLM)-induced fibrosis model is the most widely used in systemic sclerosis (SSc) studies. It has been reported that systemic delivery of BLM via continuous diffusion from subcutaneously implanted osmotic minipumps can cause fibrosis of the skin, lungs, and other internal organs. However, the mouse strain, dosage of BLM, administration period, and additional important features differ from one report to the next. Read More

    Photodynamic therapy in dermatology beyond non-melanoma cancer: An update.
    Photodiagnosis Photodyn Ther 2017 Sep 21;19:140-152. Epub 2017 Jun 21.
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA. Electronic address:
    Photodynamic therapy (PDT) employs a photosensitizer (PS) and visible light in the presence of oxygen, leading to production of cytotoxic reactive oxygen species, which can damage the cellular organelles and cause cell death. In dermatology, PDT has usually taken the form of topical application of a precursor in the heme biosynthesis pathway, called 5-aminolevulinic acid (or its methyl ester), so that an active PS, protoporphyrin IX accumulates in the skin. As PDT enhances dermal remodeling and resolves chronic inflamation, it has been used to treat cutaneous disorders include actinic keratoses, acne, viral warts, skin rejuvenation, psoriasis, localized scleroderma, some non-melanoma skin cancers and port-wine stains. Read More

    [Granulomatous reaction pattern of the skin : Interstitial granulomatous dermatitis - lymphoma - vasculitis].
    Hautarzt 2017 Jul;68(7):553-559
    Konsultations- und Referenzzentrum für Vaskulitis-Diagnostik, MVZ am Marienkrankenhaus gGmbH, Hamburg, Deutschland.
    A particular diagnostic situation in the classification of a granulomatous dermatitis results when no circumscribed granulomas but instead a diffuse interstitial histiocytic inflammatory infiltrate, a granulomatous vasculitis or a neoplastic lymphocytic infiltrate is found. Interstitial granulomatous dermatitis was originally described in patients with arthritis. Later, it was recognized that there are also associations with other usually immunological diseases. Read More

    Scleroderma-like Disorders.
    Curr Rheumatol Rev 2017 06 11. Epub 2017 Jun 11.
    Fortis Escorts Hospital, Jaipur, India
    Scleroderma is a term used to describe diseases that involve hardening and tightening of the skin and the underlying subcutaneous connective tissue. It could be localized to skin and subcutaneous tissue, or may involve the internal organs too in systemic sclerosis. There are disorders that can cause hardening and tightening of skin and mimic scleroderma but are rarely associated with Raynaud phenomenon, sclerodactyly, and autoantibodies in the serum, features specific to scleroderma/systemic sclerosis. Read More

    The efficacy of methotrexate in the treatment of en coup de sabre (linear morphea subtype).
    J Dermatolog Treat 2017 Jun 29. Epub 2017 Jun 29.
    b Department of Dermatology, Wake Forest School of Medicine , Winston Salem , NC , USA.
    Background: En coup de sabre is a rare subtype of linear morphea, located on the forehead or frontoparietal scalp. Systemic treatment of localised morphea with methotrexate has been reported in a few clinical reports. However, there are no case series using methotrexate treatment for En coup de sabre. Read More

    Periostin in Mature Stage Localized Scleroderma.
    Ann Dermatol 2017 Jun 11;29(3):268-275. Epub 2017 May 11.
    Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.
    Background: Periostin is a novel matricellular protein expressed in many tissues, including bone, periodontal ligament, and skin. Although its expression is prominent in various fibrotic conditions, studies of periostin in localized scleroderma are rare.

    Objective: To investigate the expression of periostin and other molecules in localized scleroderma. Read More

    1 OF 99