5,147 results match your criteria Morphea


Dermoscopy of Morphea.

Indian Dermatol Online J 2019 Jan-Feb;10(1):92-93

Department of Dermatology, Government Medical College Srinagar, Karan Nagar Srinagar, Jammu and Kashmir, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_350_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362751PMC
February 2019

Radiation-induced morphea: autoimmunity as a risk factor.

Neth J Med 2019 Jan;77(1):29-31

Department of Dermatology, Mohammed V Military Hospital, Mohammed V University of Rabat, Rabat, Morocco.

Radiation-induced morphea (RIM) is a rare complication of radiotherapy of unknown etiology. We report the case of a woman with a history of vitiligo and Hashimoto's thyroiditis, who developed RIM following radiotherapy for breast carcinoma. We suggest that a history of autoimmune disease is a possible risk factor for the development of RIM. Read More

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January 2019

Juvenile polyautoimmunity in a rheumatology setting.

Autoimmun Rev 2019 Feb 14. Epub 2019 Feb 14.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.. Electronic address:

Overt polyautoimmunity (PolyA) corresponds to the presence of more than one well-defined autoimmune disease (AD) manifested clinically in a single patient. The current study aimed to describe the main characteristics of juvenile PolyA in a pediatric rheumatology setting and analyze the chronological aspects, index cases, familial autoimmunity, and clustering pattern. This was a cross-sectional and multicenter study in which 313 children with overt PolyA were included. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.11.006DOI Listing
February 2019

En coup de sabre.

Cutis 2019 Jan;103(1):34-36

St. Joseph Mercy Hospital System, Reichert Health Center, Ypsilanti, Michigan, USA.

En coup de sabre (ECDS) is a rare form of localized scleroderma that typically manifests in children and women. It presents as a fibrous pansclerotic plaque extending in a bandlike distribution on the frontoparietal scalp with surrounding scarring alopecia. Many patients have comorbid central nervous system involvement in addition to the cutaneous findings. Read More

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January 2019
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Protean Neurologic Manifestations of Two Rare Dermatologic Disorders: Sweet Disease and Localized Craniofacial Scleroderma.

Curr Neurol Neurosci Rep 2019 Feb 12;19(3):11. Epub 2019 Feb 12.

NYU Multiple Sclerosis Comprehensive Care Center, Department of Neurology, New York University School of Medicine, New York, NY, USA.

Purpose Of Review: To describe diverse neurologic and neuroradiologic presentations of two rare, immunologically mediated skin conditions: Sweet disease and localized scleroderma (morphea).

Recent Findings: Core syndromes of neuro-Sweet disease (NSD) are steroid responsiveness, recurrent meningitis, and encephalitis. Focal neurologic, neuro-vascular, and neuro-ophthalmologic syndromes have been reported recently in NSD. Read More

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http://dx.doi.org/10.1007/s11910-019-0929-8DOI Listing
February 2019
1 Read

Botulinum toxin A for pain reduction in pediatric patients with Parry-Romberg syndrome.

Pediatr Dermatol 2019 Feb 10. Epub 2019 Feb 10.

Pediatric Dermatology, Phoenix Children's Hospital, Phoenix, Arizona.

Parry-Romberg syndrome (PRS) is characterized by hemiatrophy of facial structures, including skin, subcutaneous fat, muscle, bone, and cartilage. Complications associated with PRS include headaches, seizures, and chronic facial pain. Protocol for the treatment of chronic facial pain is not clear; reports on the use of botulinum toxin A injections for pain reduction in adults but not in the pediatric/adolescent population are available. Read More

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http://dx.doi.org/10.1111/pde.13746DOI Listing
February 2019
1 Read

A case of linear morphea involving the oral cavity.

JAAD Case Rep 2019 Feb 25;5(2):144-146. Epub 2019 Jan 25.

Department of Dermatology, University of Texas McGovern Medical School, Houston, Texas.

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http://dx.doi.org/10.1016/j.jdcr.2018.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355322PMC
February 2019
1 Read

An evaluation of long-term outcomes and recurrence rates in patients with morphea.

Int J Dermatol 2019 Feb 1. Epub 2019 Feb 1.

Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia.

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http://dx.doi.org/10.1111/ijd.14401DOI Listing
February 2019
1 Read

Treatment of Morphea With Hydroxychloroquine: A Retrospective Review of 84 Patients at Mayo Clinic, 1996-2013.

J Am Acad Dermatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background: Few studies support treating morphea (localized scleroderma) with hydroxychloroquine.

Objective: To assess the efficacy of hydroxychloroquine treatment of morphea.

Methods: We conducted a retrospective study of 84 patients who had morphea and were treated with hydroxychloroquine monotherapy for at least 6 months at our institution from 1996 through 2013. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622193014
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http://dx.doi.org/10.1016/j.jaad.2019.01.040DOI Listing
January 2019
6 Reads

Juvenile case of multiple morphea profunda resulting in joint contracture that was successfully treated with cyclosporin A: A case report and review of the published works.

J Dermatol 2019 Jan 31. Epub 2019 Jan 31.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Morphea profunda refers to inflammatory and sclerotic lesions that start primarily from the deep dermis, subcutaneous fat and fascia. Its pediatric case published work is limited. Here, we report the case of an 8-year-old girl with a 5-year history of multiple subcutaneous nodules on her extremities and a right wrist joint contracture who had been previously diagnosed with juvenile idiopathic arthritis and treated with salazosulfapyridine, low-dose prednisolone (PSL) and methotrexate. Read More

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http://dx.doi.org/10.1111/1346-8138.14801DOI Listing
January 2019
1 Read

A Case of Pansclerotic Morphea Treated With Tocilizumab.

JAMA Dermatol 2019 Jan 16. Epub 2019 Jan 16.

Department of Dermatology and Pediatrics (Pediatric Dermatology), Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2018.5040DOI Listing
January 2019
5 Reads

An extended high-frequency ultrasound protocol for assessing and quantifying of inflammation and fibrosis in localized scleroderma.

Skin Res Technol 2019 Jan 14. Epub 2019 Jan 14.

Chair and Department of Dermatology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Background: Clinical characteristics of the lesions are used to identify activity and damage in localized scleroderma (LoS). For high-frequency ultrasound (HF-US), the features of active lesions were described.

Materials And Methods: Clinical signs of activity and damage in LoS lesions were assessed with the use of Localized Scleroderma Cutaneous Assessment Tool (LoSCAT) and HF-US by two examiners independently. Read More

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http://dx.doi.org/10.1111/srt.12660DOI Listing
January 2019
1 Read

Juvenile Scleroderma: A Referral Center Experience.

Arch Rheumatol 2018 Sep 18;33(3):344-351. Epub 2018 Jan 18.

Department of Pediatric Rheumatology, İstanbul University, Cerrahpasa Medical School, İstanbul, Turkey.

Objectives: This study aims to evaluate the demographic and clinical features, laboratory data, treatment modalities, and outcomes of juvenile systemic sclerosis (JSS) and juvenile localized scleroderma (JLS) patients at a referral pediatric rheumatology center in Turkey.

Patients And Methods: Medical records of a total of 57 patients, including 29 with JSS (1 male, 28 females; mean age 18.3±3. Read More

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https://www.archivesofrheumatology.org/full-text/948
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http://dx.doi.org/10.5606/ArchRheumatol.2018.6578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328218PMC
September 2018
6 Reads

The correlation between serum E-selectin levels and soluble interleukin-2 receptors with relation to disease activity in localized scleroderma.

Postepy Dermatol Alergol 2018 Dec 13;35(6):614-619. Epub 2018 Nov 13.

Department of Dermatology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Introduction: Scleroderma is a chronic connective tissue disease resulting in fibrosis.

Aim: The aim of the study was to determine the connection between sE-selectin and sIL-2R and the severity of skin lesions in various subtypes of LoS. Evaluation of disease severity, the location of skin lesions, the duration of symptoms and disease activity were assessed in relation to the three different LoS subtypes in patients with localized scleroderma. Read More

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http://dx.doi.org/10.5114/ada.2018.77613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320493PMC
December 2018
1 Read

Identifying the Signature Immune Phenotypes Present in Pediatric Localized Scleroderma.

J Invest Dermatol 2018 Oct 25. Epub 2018 Oct 25.

Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X183269
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http://dx.doi.org/10.1016/j.jid.2018.09.025DOI Listing
October 2018
2 Reads
7.216 Impact Factor

Postirradiation morphea: unique presentation on the breast.

Cutis 2018 Nov;102(5):E10-E12

Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.

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November 2018
1 Read

Multi-centre national audit of juvenile localised scleroderma: describing current UK practice in disease assessment and management.

Pediatr Rheumatol Online J 2018 Dec 18;16(1):80. Epub 2018 Dec 18.

Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Eaton Road, Liverpool, L12 2AP, UK.

Objective: To describe current United Kingdom practice in assessment and management of patients with juvenile localised scleroderma (JLS) compared to Paediatric Rheumatology European Society (PRES) scleroderma working party recommendations.

Methods: Patients were included if they were diagnosed with JLS and were under the care of paediatric rheumatology between 04/2015-04/2016. Retrospective data was collected in eleven UK centres using a standardised proforma and collated centrally. Read More

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http://dx.doi.org/10.1186/s12969-018-0295-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299547PMC
December 2018
1 Read

Bee venom acupuncture for circumscribed morphea in a patient with systemic sclerosis: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13404

Department of Acupuncture and Moxibustion Medicine, Dongguk University Ilsan Oriental Hospital, Goyang, Republic of Korea.

Rationale: Bee venom has been reported to demonstrate antinociceptive and anti-inflammatory effects in experimental studies, but there remain questions regarding the clinical use of bee venom, especially for scleroderma. This case report shows the successful outcome of bee venom acupuncture for circumscribed morphea in a patient with systemic sclerosis, which is considered to be a rare condition.

Patient Concerns: A 64-year-old Korean woman had circular white areas (3 and 1 cm diameter) with severe itch in the right lateral iliac crest. Read More

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http://dx.doi.org/10.1097/MD.0000000000013404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310600PMC
December 2018
1 Read

Erster Fallbericht einer beidseitigen zirkumskripten Morphea des Gesichts.

J Dtsch Dermatol Ges 2018 Dec;16(12):1480-1482

Dermatology, Venereology and Leprosy, Ellahi Medicare Clinic, Kashmir, India.

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http://dx.doi.org/10.1111/ddg.13705_gDOI Listing
December 2018

The influence of interferon on healthy and diseased skin.

Cytokine 2018 Dec 6. Epub 2018 Dec 6.

Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Type I interferons (IFNs) are an immunomodulatory class of cytokines that serve to protect against viral and bacterial infection. In addition, mounting evidence suggests IFNs, particularly type I but also IFNγ, are important to the pathogenesis of autoimmune and inflammatory skin diseases, such as cutaneous lupus erythematosus (CLE). Understanding the role of IFNs is relevant to anti-viral responses in the skin, skin biology, and therapeutics for these IFN-related conditions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666183044
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http://dx.doi.org/10.1016/j.cyto.2018.11.022DOI Listing
December 2018
3 Reads

Unilateral generalized morphea: First case report in Taiwan.

Asian Pac J Allergy Immunol 2018 Dec 9. Epub 2018 Dec 9.

Department of Allergy, Immunology and Rheumatology, Mackay Children's Hospital, Taipei, Taiwan.

Generalised morphea (GM) is a subtype of localised scleroderma that usually manifests with bilateral involvement. Unilateral generalised morphea (UGM) is a rare variant of GM. This is a case report of a Taiwanese girl with UGM over the left side of her body. Read More

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http://dx.doi.org/10.12932/AP-020818-0387DOI Listing
December 2018
1 Read

Anti-Centromere Antibody Positivity in a Patient with Generalized Morphea.

Case Rep Dermatol 2018 Sep-Dec;10(3):226-230. Epub 2018 Oct 18.

Department of Dermatology, Nara Medical University School of Medicine, Kashihara, Japan.

We report the case of a 45-year-old female with generalized morphea (GM), who exhibited positivity for the anti-centromere antibody (Ab). She frequently developed multiple sclerotic skin lesions, whose histological findings were compatible with morphea. She demonstrated favorable responses to topical and oral steroids. Read More

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https://www.karger.com/Article/FullText/493180
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http://dx.doi.org/10.1159/000493180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276767PMC
October 2018
10 Reads

A case of ulceroglandular tularemia presenting with lymphadenopathy and an ulcer on a linear morphoea lesion surrounded by erysipelas.

Int Med Case Rep J 2018 12;11:313-318. Epub 2018 Nov 12.

Department of Infectious Diseases, Regional Hospital of Bellinzona e Valli, 6500 Bellinzona, Ticino, Switzerland.

Tularemia is a zoonosis caused by the infection of (a gram-negative aerobic bacterium). Transmission to other animals or humans usually occurs through insect or tick bites, direct contact with a contaminated environment (mud or water), infected animals - mainly lagomorphs - or by ingesting undercooked meat or inhaling contaminated dust (hay or soil). This paper discusses the case of a 32-year-old man, who came to our Emergency Room presenting with persistent fever, inguinal lymphadenopathy, and an ulcer on his left lower limb on a linear morphoea lesion that had been there for some time. Read More

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http://dx.doi.org/10.2147/IMCRJ.S178561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237246PMC
November 2018
3 Reads

Comparison of 2-D shear wave elastography with clinical score in localized scleroderma: A new method to increase the diagnostic accuracy.

J Dermatol 2019 Feb 3;46(2):131-138. Epub 2018 Dec 3.

Fudan University, Department of Radiation Oncology, Zhongshan Hospital, School of Medicine, Fudan University, Shanghai, China.

There is no established diagnostic criteria or widely accepted severity classification of localized scleroderma (LS) by imaging. Acoustic radiation force impulse (ARFI) technology by normalized mean shear wave velocity (SWV) may be as a probing tool for diagnosing and staging LS accurately and objectively. Fifty-six patients with LS of inflammatory (n = 21), sclerotic (n = 24) and atrophic (n = 11) stage and 30 healthy controls were evaluated on the basis of pathological results. Read More

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http://doi.wiley.com/10.1111/1346-8138.14713
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http://dx.doi.org/10.1111/1346-8138.14713DOI Listing
February 2019
8 Reads

Linear lipoatrophy following intra-articular triamcinolone acetonide injection mimicking linear scleroderma.

Pediatr Dermatol 2019 Jan 28;36(1):e56-e57. Epub 2018 Nov 28.

Division of Rheumatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire.

A 12-year-old female with oligoarticular juvenile inflammatory arthritis developed an atrophic linear plaque involving the left medial forearm and proximal arm 7 months after intra-articular triamcinolone injection for arthritis. The plaque spontaneously resolved without treatment over approximately one year. It is important to recognize this rare complication of intra-articular steroid injection in order to avoid potential misdiagnosis as linear scleroderma and subsequent immunosuppressive treatment. Read More

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http://dx.doi.org/10.1111/pde.13736DOI Listing
January 2019
1 Read

The "Line Sign" Is a Rapid and Efficient Diagnostic "Test" for Morphea: Clinicopathological Study of 73 Cases.

Am J Dermatopathol 2018 Dec;40(12):873-878

Professor of Clinical Dermatology and Pathology Director, UC Davis Dermatopathology Service Executive Vice Chair of Academic Affairs, Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA.

Histologic clues that facilitate rapid diagnosis of morphea at scanning magnification have been described but not well studied. We examined 73 cases of morphea and 42 control cases to determine the sensitivity and specificity of a novel histopathological feature-"the line sign (LS)"-a prominent, straight interface between subcutis and adjacent collagen. The sensitivity of LS was shown to be the most sensitive feature among 4 other existing histopathological features. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001177DOI Listing
December 2018
1 Read

Connective Tissue Disease: Current Concepts.

Dermatol Clin 2019 Jan 1;37(1):37-48. Epub 2018 Nov 1.

Departments of Dermatology and Pathology, Cleveland Clinic Lerner College of Medicine, 9500 Euclid Avenue A61, Cleveland, OH 44195, USA. Electronic address:

Connective tissue diseases often prominently affect the skin, requiring dermatologists to play an important role in diagnosis and treatment of these patients. Herein we describe updates on the pathogenesis, clinical features, and treatment of 4 major connective tissue diseases: dermatomyositis, cutaneous lupus erythematosus, limited scleroderma (morphea), and cutaneous vasculitis. Many of these updates promise to improve clinical care of patients who suffer from dermatologic involvement of these diseases and are the result of research performed by dermatologists who have expertise in these conditions. Read More

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http://dx.doi.org/10.1016/j.det.2018.07.006DOI Listing
January 2019
2 Reads

Bilateral facial circumscribed morphea: The first case report.

J Dtsch Dermatol Ges 2018 Dec 22;16(12):1480-1482. Epub 2018 Nov 22.

Dermatology, Venereology and Leprosy, Ellahi Medicare Clinic, Kashmir, India.

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http://dx.doi.org/10.1111/ddg.13705DOI Listing
December 2018
2 Reads

A case of juvenile localized scleroderma with anti-topoisomerase I antibody.

Eur J Dermatol 2018 Nov 13. Epub 2018 Nov 13.

Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1684/ejd.2018.3426DOI Listing
November 2018
5 Reads

Morphea and antithyroid antibodies.

Postepy Dermatol Alergol 2018 Oct 19;35(5):470-473. Epub 2018 Jul 19.

Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

Introduction: Morphea, also known as localized scleroderma, is an autoimmune skin disease which is characterized by excessive accumulation of collagen that leads to the thickening of the dermis and subcutaneous tissue. There is an unclear relationship between morphea and other autoimmune diseases, especially related to the thyroid gland.

Aim: To determine the occurrence of increased antithyroid antibodies in patients with morphea in relation to the clinical manifestations of the disease. Read More

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http://dx.doi.org/10.5114/ada.2018.75839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232544PMC
October 2018

Comorbidity of localized scleroderma and primary biliary cholangitis.

J Dtsch Dermatol Ges 2018 Nov;16(11):1323-1327

Department of Dermatology, Venereology and Dermato-Oncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

Background And Objectives: Morphea is frequently associated with other autoimmune disorders. Little is known about the association of morphea and primary biliary cholangitis (PBC). The objective of this case series was to study the possible association of morphea with PBC and to identify risk factors. Read More

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http://doi.wiley.com/10.1111/ddg.13693
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http://dx.doi.org/10.1111/ddg.13693DOI Listing
November 2018
9 Reads

Postirradiation Morphea in Patients With Breast Cancer: Possible Association With Other Autoimmune Diseases.

Actas Dermosifiliogr 2018 Oct 30. Epub 2018 Oct 30.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España.

Postirradiation morphea is an uncommon entity that has been mostly described in women with breast cancer. The increasing use of radiotherapy to treat breast cancer and the clinical similarities between morphea and other conditions, such as radiodermatitis, postirradiation fibrosis, and tumor recurrence, highlights the need for dermatologists to be familiar with this entity. We present a series of 6 women with a mean age of 64. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00017310183043
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http://dx.doi.org/10.1016/j.ad.2017.10.028DOI Listing
October 2018
18 Reads

Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause profibrotic changes in linear morphoea fibroblasts.

Br J Dermatol 2018 Oct 26. Epub 2018 Oct 26.

Immunobiology and Dermatology, UCL Institute of Child Health, London, U.K.

Background: Linear morphoea (LM) is a rare connective tissue disorder characterized by a line of thickened skin and subcutaneous tissue and can also affect the underlying muscle and bone. Little is known about the disease aetiology, with treatment currently limited to immune suppression, and disease recurrence post-treatment is common.

Objectives: In order to uncover new therapeutic avenues, the cell-intrinsic changes in LM fibroblasts compared with site-matched controls were characterized. Read More

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http://doi.wiley.com/10.1111/bjd.17352
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http://dx.doi.org/10.1111/bjd.17352DOI Listing
October 2018
7 Reads

A Case of Bullous Morphea Resistant to Methotrexate and Phototherapy Successfully Treated With Mycophenolate Mofetil.

J Drugs Dermatol 2018 Oct;17(10):1123-1125

Bullous morphea is rare clinical variant of localized scleroderma characterized by the formation of bullae on sclerotic morphea plaques. Severe disease may be highly disabling and greatly impair quality of life. Current treatment strategies are based on anecdotal reports of clinical experience and include topical corticosteroids, methotrexate and phototherapy. Read More

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October 2018
12 Reads

Localized scleroderma causing enophthalmos: A rare entity.

Indian J Ophthalmol 2018 Nov;66(11):1611-1612

Department of Dermatology, Venereology and Leprosy, Alluri Sitarama Raju Academy of Medical Sciences, Eluru, Andhra Pradesh, India.

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http://dx.doi.org/10.4103/ijo.IJO_303_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213687PMC
November 2018
2 Reads

Morphea and systemic sclerosis are associated with an increased risk of melanoma and non-melanoma skin cancer.

J Am Acad Dermatol 2018 Oct 20. Epub 2018 Oct 20.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD; Johns Hopkins Bloomberg School of Public Health. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.10.022DOI Listing
October 2018
2 Reads

A surgical approach to linear scleroderma using Medpor and dermal fat graft.

Arch Craniofac Surg 2018 Oct 16. Epub 2018 Oct 16.

Department of Plastic and Reconstructive Surgery, Busan Paik Hospital, Inje University School of Medicine, Busan, Korea.

Linear scleroderma en coup de sabre (LScs) is a variant of localized scleroderma. This disease typically occurs in patients in their 20s or younger individuals and predominantly occurs in the forehead area. A 26-year-old man with linear scleroderma was surgically treated at our center with Medpor (porous polyethylene) and dermal fat graft for the forehead lesion. Read More

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http://dx.doi.org/10.7181/acfs.2018.01935DOI Listing
October 2018
1 Read

Tick Bite-Associated Morphea: A Case Report.

Am J Dermatopathol 2018 Oct 9. Epub 2018 Oct 9.

Department of Dermatology, University of Florida College of Medicine, Gainesville, FL.

Borrelia burgdorferi, the causative organism of Lyme disease, has been linked to the development of scleroatrophic skin conditions including morphea, although this association remains controversial. The possibility that tick bite with or without concurrent Borrelia infection instigates that morphea development is important to recognize because this could prompt further workup for Lyme disease, or other tick-borne illness, which, when untreated, can have devastating consequences. Here, we report a case of a woman with a history of previous tick bite in the location of morphea. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001290DOI Listing
October 2018
6 Reads

Prediction of disease relapse in a cohort of paediatric patients with localized scleroderma.

Br J Dermatol 2018 Oct 13. Epub 2018 Oct 13.

Children's Hospital of Pittsburgh of Univeristy of Pittsburgh Medical Center, University of Pittsburgh Scleroderma Center, Pittsburgh, PA, U.S.A.

Background: Localized scleroderma (LS) is an autoimmune condition of the skin and underlying tissue. Active or recurring disease can lead to cumulative tissue damage, especially in paediatric-onset disease.

Objectives: To highlight the rate of relapse of LS activity in a cohort of paediatric patients and to evaluate for potential clinical and laboratory predictors of disease relapse. Read More

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http://dx.doi.org/10.1111/bjd.17312DOI Listing
October 2018
1 Read

Nivolumab induced morphea.

G Ital Dermatol Venereol 2018 Oct 3. Epub 2018 Oct 3.

Section of Dermatology, Department of Medicine, University of Verona, Verona, Italy.

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https://www.minervamedica.it/index2.php?show=R23Y9999N00A181
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http://dx.doi.org/10.23736/S0392-0488.18.06118-7DOI Listing
October 2018
1 Read

Scleredema of Buschke associated with lichen sclerosus: Three cases.

Indian J Dermatol Venereol Leprol 2018 Oct 4. Epub 2018 Oct 4.

"Mario Aresu" Department of Medical Science, Section of Dermatology, University of Cagliari, Cagliari, Italy.

Scleredema adultorum of Buschke is a rare fibromucinous, scleroderma-like connective tissue disease most commonly found in a post-infectious setting or linked to hematological disorders or diabetes. Lichen sclerosus et atrophicus is an autoimmune condition only in 2.5% of cases localized exclusively at an extragenital site, occurring in up to 34% of patients in association with other autoimmune diseases such as vitiligo, thyroid disorders, alopecia areata, lichen planus, morphea, pernicious anemia and systemic lupus erythematosus. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_288_17DOI Listing
October 2018
6 Reads

A rare case of a tattoo-induced morphoea reaction.

Clin Exp Dermatol 2018 Oct 2. Epub 2018 Oct 2.

Department of Dermatology, Medway NHS Foundation Trust, Windmill Rd, Gillingham, Kent, ME7 5NY, UK.

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http://dx.doi.org/10.1111/ced.13797DOI Listing
October 2018

Collagen Vascular Diseases: SLE, Dermatomyositis, Scleroderma, and MCTD.

Pediatr Rev 2018 Oct;39(10):501-515

Division of Pediatric Rheumatology, Department of Pediatrics, University of Minnesota and the University of Minnesota Masonic Children's Hospital, Minneapolis, MN.

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http://dx.doi.org/10.1542/pir.2017-0262DOI Listing
October 2018
8 Reads

Progranulin overproduction due to constitutively activated c-Abl/PKC-δ/Fli1 pathway contributes to the resistance of dermal fibroblasts to the anti-fibrotic effect of tumor necrosis factor-α in localized scleroderma.

J Dermatol Sci 2018 Nov 19;92(2):207-214. Epub 2018 Sep 19.

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, 113-8655, Japan. Electronic address:

Background: Dermal fibroblasts derived from patients with systemic sclerosis (SSc) overproduce progranulin (PGRN), an endogenous antagonist of tumor necrosis factor (TNF) receptors, due to the deficiency of transcription factor Fli1. Fli1 expression is also decreased in dermal fibroblasts derived from patients with localized scleroderma (LSc).

Objective: To investigate the expression levels of PGRN and its contribution to the induction of pro-fibrotic phenotype in LSc dermal fibroblasts. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.09.005DOI Listing
November 2018
8 Reads

[Mimetics of systemic sclerosis].

Z Rheumatol 2019 Feb;78(1):14-23

Klinik für Rheumatologie und klinische Immunologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Background: Systemic sclerosis (SSc) is characterized by heterogeneous clinical symptoms. Peripheral skin fibrosis can be a common symptom. Nevertheless, a variety of diseases with different etiologies are associated with a thickening of the skin and make the initial diagnosis of systemic sclerosis more difficult. Read More

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http://dx.doi.org/10.1007/s00393-018-0538-yDOI Listing
February 2019
12 Reads

[Morphea or localized scleroderma and extragenital lichen sclerosus].

Hautarzt 2018 Nov;69(11):892-900

Klinik und Poliklinik für Dermatologie und Venerologie, Universität zu Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

Localized scleroderma (LoS) is a very heterogeneous connective tissue disease characterized by progressive sclerosis of the skin with possible involvement of extracutaneous structures. Both children and adults can be affected but show different frequencies for the individual subtypes of the disease. The clinical heterogeneity has already caused several modifications of existing classification criteria. Read More

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http://dx.doi.org/10.1007/s00105-018-4266-7DOI Listing
November 2018
4 Reads

Morphea associated with primary biliary cirrhosis and Waldenstrom macroglobulinemia: Response to rituximab.

JAAD Case Rep 2018 Sep 14;4(8):784-787. Epub 2018 Sep 14.

Division of Dermatology, University of Calgary, Richmond Road Diagnostic and Treatment Centre, Calgary, Canada.

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http://dx.doi.org/10.1016/j.jdcr.2018.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141651PMC
September 2018
5 Reads