5,120 results match your criteria Morphea
Medicine (Baltimore) 2018 Dec;97(49):e13404
Department of Acupuncture and Moxibustion Medicine, Dongguk University Ilsan Oriental Hospital, Goyang, Republic of Korea.
Rationale: Bee venom has been reported to demonstrate antinociceptive and anti-inflammatory effects in experimental studies, but there remain questions regarding the clinical use of bee venom, especially for scleroderma. This case report shows the successful outcome of bee venom acupuncture for circumscribed morphea in a patient with systemic sclerosis, which is considered to be a rare condition.
Patient Concerns: A 64-year-old Korean woman had circular white areas (3 and 1 cm diameter) with severe itch in the right lateral iliac crest. Read More
J Dtsch Dermatol Ges 2018 Dec;16(12):1480-1482
Dermatology, Venereology and Leprosy, Ellahi Medicare Clinic, Kashmir, India.
Cytokine 2018 Dec 6. Epub 2018 Dec 6.
Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:
Type I interferons (IFNs) are an immunomodulatory class of cytokines that serve to protect against viral and bacterial infection. In addition, mounting evidence suggests IFNs, particularly type I but also IFNγ, are important to the pathogenesis of autoimmune and inflammatory skin diseases, such as cutaneous lupus erythematosus (CLE). Understanding the role of IFNs is relevant to anti-viral responses in the skin, skin biology, and therapeutics for these IFN-related conditions. Read More
Asian Pac J Allergy Immunol 2018 Dec 9. Epub 2018 Dec 9.
Department of Allergy, Immunology and Rheumatology, Mackay Children's Hospital, Taipei, Taiwan.
Generalised morphea (GM) is a subtype of localised scleroderma that usually manifests with bilateral involvement. Unilateral generalised morphea (UGM) is a rare variant of GM. This is a case report of a Taiwanese girl with UGM over the left side of her body. Read More
Case Rep Dermatol 2018 Sep-Dec;10(3):226-230. Epub 2018 Oct 18.
Department of Dermatology, Nara Medical University School of Medicine, Kashihara, Japan.
We report the case of a 45-year-old female with generalized morphea (GM), who exhibited positivity for the anti-centromere antibody (Ab). She frequently developed multiple sclerotic skin lesions, whose histological findings were compatible with morphea. She demonstrated favorable responses to topical and oral steroids. Read More
Int Med Case Rep J 2018 12;11:313-318. Epub 2018 Nov 12.
Department of Infectious Diseases, Regional Hospital of Bellinzona e Valli, 6500 Bellinzona, Ticino, Switzerland.
Tularemia is a zoonosis caused by the infection of (a gram-negative aerobic bacterium). Transmission to other animals or humans usually occurs through insect or tick bites, direct contact with a contaminated environment (mud or water), infected animals - mainly lagomorphs - or by ingesting undercooked meat or inhaling contaminated dust (hay or soil). This paper discusses the case of a 32-year-old man, who came to our Emergency Room presenting with persistent fever, inguinal lymphadenopathy, and an ulcer on his left lower limb on a linear morphoea lesion that had been there for some time. Read More
J Dermatol 2018 Dec 3. Epub 2018 Dec 3.
Fudan University, Department of Radiation Oncology, Zhongshan Hospital, School of Medicine, Fudan University, Shanghai, China.
There is no established diagnostic criteria or widely accepted severity classification of localized scleroderma (LS) by imaging. Acoustic radiation force impulse (ARFI) technology by normalized mean shear wave velocity (SWV) may be as a probing tool for diagnosing and staging LS accurately and objectively. Fifty-six patients with LS of inflammatory (n = 21), sclerotic (n = 24) and atrophic (n = 11) stage and 30 healthy controls were evaluated on the basis of pathological results. Read More
Am J Dermatopathol 2018 Dec;40(12):873-878
Professor of Clinical Dermatology and Pathology Director, UC Davis Dermatopathology Service Executive Vice Chair of Academic Affairs, Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA.
Histologic clues that facilitate rapid diagnosis of morphea at scanning magnification have been described but not well studied. We examined 73 cases of morphea and 42 control cases to determine the sensitivity and specificity of a novel histopathological feature-"the line sign (LS)"-a prominent, straight interface between subcutis and adjacent collagen. The sensitivity of LS was shown to be the most sensitive feature among 4 other existing histopathological features. Read More
Dermatol Clin 2019 Jan 1;37(1):37-48. Epub 2018 Nov 1.
Departments of Dermatology and Pathology, Cleveland Clinic Lerner College of Medicine, 9500 Euclid Avenue A61, Cleveland, OH 44195, USA. Electronic address:
Connective tissue diseases often prominently affect the skin, requiring dermatologists to play an important role in diagnosis and treatment of these patients. Herein we describe updates on the pathogenesis, clinical features, and treatment of 4 major connective tissue diseases: dermatomyositis, cutaneous lupus erythematosus, limited scleroderma (morphea), and cutaneous vasculitis. Many of these updates promise to improve clinical care of patients who suffer from dermatologic involvement of these diseases and are the result of research performed by dermatologists who have expertise in these conditions. Read More
J Dtsch Dermatol Ges 2018 Dec 22;16(12):1480-1482. Epub 2018 Nov 22.
Dermatology, Venereology and Leprosy, Ellahi Medicare Clinic, Kashmir, India.
Eur J Dermatol 2018 Nov 13. Epub 2018 Nov 13.
Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Postepy Dermatol Alergol 2018 Oct 19;35(5):470-473. Epub 2018 Jul 19.
Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
Introduction: Morphea, also known as localized scleroderma, is an autoimmune skin disease which is characterized by excessive accumulation of collagen that leads to the thickening of the dermis and subcutaneous tissue. There is an unclear relationship between morphea and other autoimmune diseases, especially related to the thyroid gland.
Aim: To determine the occurrence of increased antithyroid antibodies in patients with morphea in relation to the clinical manifestations of the disease. Read More
J Dtsch Dermatol Ges 2018 Nov;16(11):1323-1327
Department of Dermatology, Venereology and Dermato-Oncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Background And Objectives: Morphea is frequently associated with other autoimmune disorders. Little is known about the association of morphea and primary biliary cholangitis (PBC). The objective of this case series was to study the possible association of morphea with PBC and to identify risk factors. Read More
Actas Dermosifiliogr 2018 Oct 30. Epub 2018 Oct 30.
Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España.
Postirradiation morphea is an uncommon entity that has been mostly described in women with breast cancer. The increasing use of radiotherapy to treat breast cancer and the clinical similarities between morphea and other conditions, such as radiodermatitis, postirradiation fibrosis, and tumor recurrence, highlights the need for dermatologists to be familiar with this entity. We present a series of 6 women with a mean age of 64. Read More
Br J Dermatol 2018 Oct 26. Epub 2018 Oct 26.
Immunobiology and Dermatology, UCL Institute of Child Health, London, UK.
Background: Linear morphoea (LM) is a rare connective tissue disorder characterised by a line of thickened skin and subcutaneous tissue and can also affect the underlying muscle and bone. Little is known about disease aetiology, with treatment currently limited to immune suppression, and disease recurrence post-treatment is common.
Objective: To uncover new therapeutic avenues, the cell intrinsic changes in LM fibroblasts compared to site-matched controls was characterised. Read More
J Drugs Dermatol 2018 Oct;17(10):1123-1125
Bullous morphea is rare clinical variant of localized scleroderma characterized by the formation of bullae on sclerotic morphea plaques. Severe disease may be highly disabling and greatly impair quality of life. Current treatment strategies are based on anecdotal reports of clinical experience and include topical corticosteroids, methotrexate and phototherapy. Read More
Indian J Ophthalmol 2018 Nov;66(11):1611-1612
Department of Dermatology, Venereology and Leprosy, Alluri Sitarama Raju Academy of Medical Sciences, Eluru, Andhra Pradesh, India.
J Am Acad Dermatol 2018 Oct 20. Epub 2018 Oct 20.
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD; Johns Hopkins Bloomberg School of Public Health. Electronic address:
Arch Craniofac Surg 2018 Oct 16. Epub 2018 Oct 16.
Department of Plastic and Reconstructive Surgery, Busan Paik Hospital, Inje University School of Medicine, Busan, Korea.
Linear scleroderma en coup de sabre (LScs) is a variant of localized scleroderma. This disease typically occurs in patients in their 20s or younger individuals and predominantly occurs in the forehead area. A 26-year-old man with linear scleroderma was surgically treated at our center with Medpor (porous polyethylene) and dermal fat graft for the forehead lesion. Read More
Am J Dermatopathol 2018 Oct 9. Epub 2018 Oct 9.
Department of Dermatology, University of Florida College of Medicine, Gainesville, FL.
Borrelia burgdorferi, the causative organism of Lyme disease, has been linked to the development of scleroatrophic skin conditions including morphea, although this association remains controversial. The possibility that tick bite with or without concurrent Borrelia infection instigates that morphea development is important to recognize because this could prompt further workup for Lyme disease, or other tick-borne illness, which, when untreated, can have devastating consequences. Here, we report a case of a woman with a history of previous tick bite in the location of morphea. Read More
Br J Dermatol 2018 Oct 13. Epub 2018 Oct 13.
Children's Hospital of Pittsburgh of Univeristy of Pittsburgh Medical Center, University of Pittsburgh Scleroderma Center, Pittsburgh, PA, U.S.A.
Background: Localized scleroderma (LS) is an autoimmune condition of the skin and underlying tissue. Active or recurring disease can lead to cumulative tissue damage, especially in paediatric-onset disease.
Objectives: To highlight the rate of relapse of LS activity in a cohort of paediatric patients and to evaluate for potential clinical and laboratory predictors of disease relapse. Read More
G Ital Dermatol Venereol 2018 Oct 3. Epub 2018 Oct 3.
Section of Dermatology, Department of Medicine, University of Verona, Verona, Italy.
Indian J Dermatol Venereol Leprol 2018 Oct 4. Epub 2018 Oct 4.
"Mario Aresu" Department of Medical Science, Section of Dermatology, University of Cagliari, Cagliari, Italy.
Scleredema adultorum of Buschke is a rare fibromucinous, scleroderma-like connective tissue disease most commonly found in a post-infectious setting or linked to hematological disorders or diabetes. Lichen sclerosus et atrophicus is an autoimmune condition only in 2.5% of cases localized exclusively at an extragenital site, occurring in up to 34% of patients in association with other autoimmune diseases such as vitiligo, thyroid disorders, alopecia areata, lichen planus, morphea, pernicious anemia and systemic lupus erythematosus. Read More
Clin Exp Dermatol 2018 Oct 2. Epub 2018 Oct 2.
Department of Dermatology, Medway NHS Foundation Trust, Windmill Rd, Gillingham, Kent, ME7 5NY, UK.
Pediatr Rev 2018 Oct;39(10):501-515
Division of Pediatric Rheumatology, Department of Pediatrics, University of Minnesota and the University of Minnesota Masonic Children's Hospital, Minneapolis, MN.
J Dermatol Sci 2018 Nov 19;92(2):207-214. Epub 2018 Sep 19.
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, 113-8655, Japan. Electronic address:
Background: Dermal fibroblasts derived from patients with systemic sclerosis (SSc) overproduce progranulin (PGRN), an endogenous antagonist of tumor necrosis factor (TNF) receptors, due to the deficiency of transcription factor Fli1. Fli1 expression is also decreased in dermal fibroblasts derived from patients with localized scleroderma (LSc).
Objective: To investigate the expression levels of PGRN and its contribution to the induction of pro-fibrotic phenotype in LSc dermal fibroblasts. Read More
Z Rheumatol 2018 Sep 25. Epub 2018 Sep 25.
Klinik für Rheumatologie und klinische Immunologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.
Background: Systemic sclerosis (SSc) is characterized by heterogeneous clinical symptoms. Peripheral skin fibrosis can be a common symptom. Nevertheless, a variety of diseases with different etiologies are associated with a thickening of the skin and make the initial diagnosis of systemic sclerosis more difficult. Read More
Hautarzt 2018 Nov;69(11):892-900
Klinik und Poliklinik für Dermatologie und Venerologie, Universität zu Köln, Kerpener Str. 62, 50937, Köln, Deutschland.
Localized scleroderma (LoS) is a very heterogeneous connective tissue disease characterized by progressive sclerosis of the skin with possible involvement of extracutaneous structures. Both children and adults can be affected but show different frequencies for the individual subtypes of the disease. The clinical heterogeneity has already caused several modifications of existing classification criteria. Read More
JAAD Case Rep 2018 Sep 14;4(8):784-787. Epub 2018 Sep 14.
Division of Dermatology, University of Calgary, Richmond Road Diagnostic and Treatment Centre, Calgary, Canada.
Cutis 2018 08;102(2):E7-E10
Department of Dermatology and Cutaneous Biology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Int J Hematol Oncol Stem Cell Res 2018 Apr;12(2):92-97
Social Determinants of Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
The co-occurrence of different types of hemo-lymphopoietic malignancies within a family provides clues about the pattern of inheritance and common environmental risk factors. A family presented with developing hemo-lymphopoietic cancers in three female first-degree relatives: a mother and her daughters. Case 1 was diagnosed with Walden Strom's macroglobulinemia at age 57. Read More
J Rheumatol 2018 Dec 15;45(12):1680-1688. Epub 2018 Sep 15.
From the Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Department of Pediatrics, Hackensack; Stevens Institute of Technology, Hoboken, New Jersey, USA; Hospital for Sick Children, Toronto, Ontario, Canada; Texas Scottish Rite Hospital, University of Texas (UT) Southwestern, Dallas, Texas; The Ohio State University and Nationwide Children's Hospital, Columbus, Ohio; Duke University, Durham, North Carolina; Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana; Rockefeller University, New York, New York, USA; Hamburger Zentrum für Kinder- und Jugendrheumatologie, Hamburg, Germany; Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Objective: To identify clinical features that define disease activity in pediatric localized scleroderma (LS), and determine their specificity and importance.
Methods: We conducted a multicenter prospective study of patients with active and inactive LS skin lesions. A standardized evaluation of a single designated study lesion per subject was performed at 3 visits. Read More
Health Qual Life Outcomes 2018 Sep 14;16(1):185. Epub 2018 Sep 14.
Department of Dermatology, School of Medicine in Katowice, Medical University of Silesia, Francuska Str. 20/24, 40-027, Katowice, Poland.
Background: Localized scleroderma (LoS) affects both children and adults and is associated with permanent functional and cosmetic impairment, and reduced quality of life predominating in adults. The Localized Scleroderma Cutaneous Assessment Tool (LoSCAT) is a clinical instrument designed to measure an activity and damage of LoS. It has been validated for use with pediatric LoS patients. Read More
Cephalalgia 2018 Sep 13:333102418801580. Epub 2018 Sep 13.
2 Department of Dermatology, Clínica Universidad de Navarra, Pamplona, Spain.
Background Localized facial scleroderma usually presents as frontal linear morphea or progressive hemifacial atrophy. Only isolated cases of trigeminal painful neuropathy have been described. Case report A 43-year-old woman developed an oval lesion on the right cheek. Read More
Front Med (Lausanne) 2018 27;5:237. Epub 2018 Aug 27.
Department of Dermatology, Ruhr-University Bochum, Bochum, Germany.
In this article we describe efficacy and safety aspects of ultraviolet A1 (UV-A1) phototherapy in fibrosing conditions. UV-A1 is a specific phototherapeutic modality that is defined by a selective spectral range (340-400 nm). UV-A1 includes distinct modes of action qualifying this method for therapy of a variety of conditions, in particular fibrosing skin diseases. Read More
Case Rep Orthop 2018 19;2018:4535804. Epub 2018 Aug 19.
Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi 466-8550, Japan.
Localized scleroderma, also known as morphea, is a rare condition characterized by progressive sclerosis of the skin and associated atrophy of the underlying tissues. The linear type of localized scleroderma is the most frequent form in childhood, usually affecting unilateral extremities. Fibrosclerosis of the fasciae and muscles can spread across joints and impair the range of motion of the joint. Read More
Arch Rheumatol 2018 Jun 2;33(2):230-235. Epub 2017 Nov 2.
Department of Radiology, Kawaguchi Municipal Medical Center, Saitama, Japan.
Children with localized scleroderma may have more serious sequelae than adults with the disease. In this case report, we analyzed four girls with localized scleroderma (generalized morphea) to evaluate the clinical usefulness of magnetic resonance imaging in facilitating disease control and investigating patient responsiveness to various treatments. Two of the children had flexion contracture, and two displayed a clear high-intensity area in the bone marrow under the sclerotic skin on magnetic resonance imaging. Read More
Postepy Dermatol Alergol 2018 Aug 21;35(4):425-428. Epub 2018 Aug 21.
Chair of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Faculty of Medicine in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
Actas Dermosifiliogr 2018 Sep 7. Epub 2018 Sep 7.
Departamento of Dermatología, Facultad de Medicina Jawaharlal Nehru (JNMC), Universidad Aligarh Muslim (AMU), Aligarh, India.
Pediatr Dermatol 2018 Nov 6;35(6):761-768. Epub 2018 Sep 6.
Section of Dermatology, Division of Paediatric Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Background: Congenital morphea is a form of localized scleroderma that presents at birth. There is limited information on its presentation and progression.
Methods: Patients with congenital morphea were identified from five pediatric dermatology and rheumatology tertiary care centers in Canada, the United States, and Italy from 2001 to 2016. Read More
J Dtsch Dermatol Ges 2018 Sep;16(9):1120-1129
Department of Dermatology, Regensburg University Medical Center, Regensburg, Germany.
The efficacy of phototherapy is based on the interaction between ultraviolet (UV) radiation and the skin. The photobiological effects thus achieved depend on the wavelengths used. Targeted use of UVA and UVB, where indicated in combination with a photosensitizer such as psoralen, provides the dermatologist with a broad armamentarium for the treatment of a multitude of skin diseases. Read More
Int J Dermatol 2019 Jan 31;58(1):50-53. Epub 2018 Aug 31.
Department of Dermatology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Background: There is a paucity of data describing autoimmune skin diseases in sub-Saharan Africa and in HIV positive cohorts. We describe the incidence of autoimmune skin diseases in public dermatology clinics in Botswana.
Methods: New patient records from public dermatology clinics were reviewed retrospectively for the period of September 2008 to December 2015. Read More
Pediatr Dermatol 2018 Nov 31;35(6):e363-e365. Epub 2018 Aug 31.
Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Parry-Romberg syndrome (PRS) is characterized by progressive atrophy of facial skin, soft tissues, muscle, and bone. En coup de sabre syndrome is a form of linear scleroderma (LS) involving the skin of the frontoparietal forehead and scalp. Both conditions can be associated with neurologic findings, including seizures. Read More
Dermatol Ther 2018 09 28;31(5):e12699. Epub 2018 Aug 28.
Department of Cosmetology and Aesthetic Dermatology, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland.
Carbon dioxide is a physiologic compound present in our body, mainly as a result of cellular metabolism. The frequency of carboxytherapy use by dermatologists and cosmetologists increased significantly in the second half of the 20th century due to the fact that it improves blood circulation within skin tissues. This article focuses on the use of carboxytherapy in case of various skin problems, such as stretch marks, scars, loss of elasticity, redundancy of fatty tissue, cellulite, morphea, and alopecia. Read More
Clin Case Rep 2018 Aug 4;6(8):1412-1417. Epub 2018 Jun 4.
Department of Rheumatology School of Medicine University of California, San Diego La Jolla CA USA.
Although eosinophilic fasciitis is known to be part of the deep morphea spectrum, this first report of the coexistence of granulomatous fasciitis and morphea profunda suggests that granulomatous fasciitis may also be a part of the spectrum of deep morphea. Read More
Br J Dermatol 2018 Aug;179(2):245-246
Department of Psychology, University of Sheffield, Sheffield, S1 2LT, U.K.
Dermatol Ther 2018 09 22;31(5):e12674. Epub 2018 Aug 22.
Department of Dermatology and Venereology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):96-102
Department of Oculoplastic, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Purpose: Data on basal cell carcinoma (BCC) from the Middle East are deficient. We present the features and management outcomes for BCC over the last 36 years in Saudi Arabia.
Subjects And Methods: This retrospective chart review included BCC patients diagnosed and treated at Saudi Arabia between 1980 and 2016. Read More
Turk J Med Sci 2018 Aug 16;48(4):886-891. Epub 2018 Aug 16.
Background/aim: Insulin-like growth factor (IGF)-I is a differentiation and growth factor. Antifibrotic action of octreotide has been reported in pulmonary fibrosis. The present study aimed to research the prophylactic and therapeutic potential of octreotide on a bleomycin (BLM)-induced experimental scleroderma model. Read More
Reumatol Clin 2018 Aug 14. Epub 2018 Aug 14.
Servicio de Reumatología, Hospital Comarcal Alt Penedès, Vilafranca del Penedès, Barcelona, España.