5,749 results match your criteria Morphea


CAN SKIN BE A MARKER FOR INTERNAL MALIGNANCY? EVIDENCE FROM CLINICAL CASES.

Acta Clin Croat 2021 Dec;60(4):711-721

1Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 2School of Dental Medicine, University of Zagreb, Zagreb, Croatia; 3Unit of Dermatology and Venereology, Zabok General Hospital, Bračak/Zabok, Croatia; 4Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 5Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.

Although there are many single case reports on paraneoplastic dermatoses in the literature, there are very rare articles containing multiple cases. A retrospective study was performed to examine paraneoplastic dermatoses and accompanying malignancies based on skin manifestations and appropriate diagnostic evaluations. We recorded outcomes, current conditions, and surgical/oncologic treatments. Read More

View Article and Full-Text PDF
December 2021

Cutaneous manifestations following COVID-19 vaccination: A report of 25 cases.

Dermatol Ther 2022 Jun 18:e15651. Epub 2022 Jun 18.

Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Various adverse effects particularly cutaneous manifestations associated with different COVID-19 vaccines have been observed in practice.

Aim: To evaluate all patients who presented to our tertiary center with skin manifestations following COVID-19 vaccines injection from September to December 2021.

Method: All patients with skin manifestation within 30 days or less following COVID-19 vaccination were enrolled in our case-series. Read More

View Article and Full-Text PDF

Linear Morphea: A Mimicker of Motor Neuron Disease.

Ann Indian Acad Neurol 2022 Mar-Apr;25(2):278-280. Epub 2022 Jan 7.

Department of Neurology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

View Article and Full-Text PDF
January 2022

Sclerosing tenosynovitis in a patient with pan-sclerotic morphea.

Joint Bone Spine 2022 Jun 4;89(6):105421. Epub 2022 Jun 4.

Department of internal medicine and clinical immunology, university of Rennes 1, CHU Rennes, Rennes, France; Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, university of Rennes, CHU Rennes, 35000 Rennes, France.

View Article and Full-Text PDF

Dermoscopic and Reflectance Confocal Microscopy Features of Superficial Morphea on Preexisting Atrophoderma of Pasini and Pierini.

Dermatol Pract Concept 2022 May 1;12(2):e2022048. Epub 2022 Apr 1.

Department of Dermatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

View Article and Full-Text PDF

Measuring Asymmetry in Facial Morphea via 3D Stereophotogrammetry.

J Am Acad Dermatol 2022 May 25. Epub 2022 May 25.

Background: Objectively determining tissue loss in craniofacial morphea is challenging. 3D-stereophotogrammetry is a non-invasive modality that maybe a useful adjunct.

Objective: To prospectively evaluate 3D-stereophotogrammetry in assessment of craniofacial linear morphea. Read More

View Article and Full-Text PDF

Eccrine Squamous Syringometaplasia Associated With Lichen Sclerosus et Atrophicus.

Am J Dermatopathol 2022 May 30. Epub 2022 May 30.

Department of Dermatology, Rambam Health Care Campus, Haifa, Israel.

Abstract: Eccrine squamous syringometaplasia (ESS) has been associated with several conditions including morphea, linear scleroderma, and burns. It is yet to be reported in lichen sclerosus et atrophicus (LSA). We describe a bullous LSA plaque on the forearm of a woman with pre-existing genital LSA and vitiligo. Read More

View Article and Full-Text PDF

Skin eruption involving bilateral breasts following radiation therapy for invasive ductal carcinoma of the left breast.

Int J Womens Dermatol 2022 Jun 6;8(2):e016. Epub 2022 Apr 6.

Department of Dermatology, Yale School of Medicine, New Haven, Connecticut.

View Article and Full-Text PDF

A case of juvenile systemic sclerosis and congenital pulmonary airway malformation related mucinous adenocarcinoma of the lung: paraneoplastic syndrome or just a coincidence?

Turk J Pediatr 2022 ;64(2):394-399

Departments of Pediatric Rheumatology, İstanbul Cerrahpaşa University Faculty of Medicine, İstanbul, Turkey.

Background: Juvenile systemic sclerosis (JSS) is an extremely rarely seen auto-immune disease characterized by the increased fibrosis of skin and internal organs. Congenital pulmonary airway malformation (CPAM) is a developmental disorder of the lung, characterized by atypical cell hyperplasia which creates the ground for lung adenocarcinoma. In general, CPAM is diagnosed in early childhood, due to recurrent respiratory symptoms including cough, hemoptysis and respiratory infections. Read More

View Article and Full-Text PDF

Generalized morphea after COVID-19 vaccines: a case series.

J Eur Acad Dermatol Venereol 2022 May 23. Epub 2022 May 23.

Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan, Italy.

View Article and Full-Text PDF

Case Report: Bullous Pemphigoid Associated With Morphea and Lichen Sclerosus: Coincidental Diseases or Pathogenetic Association?

Front Immunol 2022 3;13:887279. Epub 2022 May 3.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Bullous pemphigoid (BP) represents the most common autoimmune bullous disease and is characterized by IgG autoantibodies targeting collagen XVII (BP180). BP has reportedly been occurred in association with other inflammatory skin diseases. Here, we describe the unusual occurrence of BP in a female patient with a concomitant history of generalized morphea (localized scleroderma, LoS) and cutaneous and genital lichen sclerosus (LiS). Read More

View Article and Full-Text PDF

Co-occurrence of linear scleroderma en coup de sabre and segmental vitiligo on the face.

BMJ Case Rep 2022 05 16;15(5). Epub 2022 May 16.

Dermatology, Venereology and Leprosy, Kasturba Medical College Mangalore, Mangalore, India.

View Article and Full-Text PDF

Clinical, Serological, and Genetic Characteristics of a Hungarian Myositis-Scleroderma Overlap Cohort.

Biomed Res Int 2022 2;2022:6251232. Epub 2022 May 2.

Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Móricz Zs. krt. 22, 4032 Debrecen, Hungary.

Overlap myositis is a distinct subgroup of idiopathic inflammatory myositis (IIM) with various clinical phenotypes. The aim of this study was to determine the clinical, serological, and genetic features of systemic sclerosis (SSc)-IIM overlap patients. It was a retrospective study using clinical database of 39 patients, fulfilling both the criteria of SSc and IIM. Read More

View Article and Full-Text PDF

Top Advances in Dermatologic Ultrasound.

Authors:
Ximena Wortsman

J Ultrasound Med 2022 May 10. Epub 2022 May 10.

Institute for Diagnostic Imaging and Research of the Skin and Soft Tissues, Santiago, Chile.

The advances in dermatologic ultrasound have been significantly influenced by the development of high- and ultrahigh-frequency probes, the provision of guidelines for performing the examinations, and a growing number of publications in the field. This review analyzes the most significant contributions that have impacted the daily practice of dermatologists in recent years. This includes the advances in anatomical detection and the patterns of benign and malignant cutaneous tumors, inflammatory dermatologic conditions, vascular anomalies, nail abnormalities, and aesthetic procedures. Read More

View Article and Full-Text PDF

Reactive granulomatous dermatitis associated with ovarian cancer and a review of its role as a harbinger for malignancy.

Dermatol Online J 2021 Dec 15;27(12). Epub 2021 Dec 15.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University Hospital, Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USA.

Reactive granulomatous dermatitis (RGD) is a rare dermatosis with a variety of cutaneous manifestations unified by a dermal granulomatous infiltrate on histology. Rheumatoid arthritis and autoimmune disease are classic associations, but an increasing number of cases have been attributed to covert malignancy. Only 41 cases of paraneoplastic RGD have been documented to our knowledge and we present an additional case that manifested eight months prior to the diagnosis of ovarian cancer and clinically mimicked morphea. Read More

View Article and Full-Text PDF
December 2021

Postradiation breast erythema, skin thickening, and peau d'orange.

JAAD Case Rep 2022 May 25;23:96-98. Epub 2022 Mar 25.

Department of Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.

View Article and Full-Text PDF

Morphea in two patients after being infected to and being vaccinated against SARS-CoV-2 infection.

Clin Case Rep 2022 Apr 18;10(4):e05667. Epub 2022 Apr 18.

Clinical Research Development Center Imam Reza Hospital Kermanshah University of Medical Sciences Kermanshah Iran.

Although the presence of morphea following COVID-19 has been rarely reported, the development of its generalized form following COVID-19 vaccination has not been reported yet. Here, we reported the first case of generalized morphea following COVID-19 vaccination and another similar case following SARS-Cov-2 infection. Other etiologic factors were also dealt with. Read More

View Article and Full-Text PDF

Autologous Concentrated Growth Factor Used to Treat Linear Scleroderma En Coup de Sabre: A Case Report.

Clin Cosmet Investig Dermatol 2022 14;15:675-679. Epub 2022 Apr 14.

Department of Dermatology, China-Japan Friendship Hospital, Beijing, People's Republic of China.

Linear scleroderma en coup de sabre (LSCS) is a variant of localized scleroderma associated with band-like fibrotic lesions in the frontoparietal area. We report a case of LSCS in a woman who presented with progressive mild hyperchromia on the right side of her forehead, with dermal atrophy and hair and eyebrow loss. After the failure of conservative treatments, the patient responded dramatically to injection of autologous localized concentrated growth factor. Read More

View Article and Full-Text PDF

An Unusual Case of Deep Localized Scleroderma in a Patient with Chronic Kidney Disease.

P R Health Sci J 2022 03;41(1):45-48

Ponce Health Sciences University School of Medicine, Ponce, PR.

Localized scleroderma (LS) is a rare fibrosing disorder of skin and underlying tissues. Although it can affect all races, it has a higher prevalence in whites. Deep LS is the least common among seven LS variants, representing less than 5% of cases, and typically affects areas of pressure such as the hips and waist. Read More

View Article and Full-Text PDF

Standardised interpretation of capillaroscopy in autoimmune idiopathic inflammatory myopathies: A structured review on behalf of the EULAR study group on microcirculation in Rheumatic Diseases.

Autoimmun Rev 2022 Jun 12;21(6):103087. Epub 2022 Apr 12.

Department of Rheumatology, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium; Department of Internal Medicine, Ghent University, C. Heymanslaan 10, 9000 Ghent, Belgium; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Technologiepark-Zwijnaarde 71, 9052, Ghent, Belgium. Electronic address:

Objective: We conducted a systematic review, on behalf of the EULAR Study Group on Microcirculation in Rheumatic Diseases (EULAR SG MC/RD), to investigate the value of nailfold videocapillaroscopy (NVC) in idiopathic inflammatory myopathies (IIM).

Methods: Three electronic databases were systematically searched to find all relevant manuscripts reporting NVC outcomes in IIM patients. Articles were assessed based on study design, population, NVC methodology and description of NVC results. Read More

View Article and Full-Text PDF

Neuromyotonia: a skin-deep problem.

BMJ Case Rep 2022 Apr 11;15(4). Epub 2022 Apr 11.

Clinique Dermatologique, Hôpitaux universitaires de Strasbourg, Strasbourg, France.

A 45-year-old woman was evaluated for right-sided hemicorporal scar-like skin lesions on her arm and thoracic and inguinal areas that appeared shortly after reduction mammoplasty. Five years later, she developed spontaneous cramps and involuntary abnormal, painful, twitching movements in the same areas. With time, the cramps worsened and disabled the patient. Read More

View Article and Full-Text PDF

Immunologic underpinnings and treatment of morphea.

Expert Rev Clin Immunol 2022 May 4;18(5):461-483. Epub 2022 May 4.

Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Introduction: Morphea is a chronic autoimmune fibrosing condition of the skin and underlying tissue with the potential for significant disease-associated morbidity. While the exact etiology of morphea is not fully elucidated, many studies have explored the immunologic drivers of this disease.

Areas Covered: Using PubMed, we performed a systematic review on morphea, with a focus on both the immune-mediated pathophysiology and treatment of this disease. Read More

View Article and Full-Text PDF

Two cases of linear cutaneous depressions after botulinum toxin A.

JAAD Case Rep 2022 Apr 19;22:93-95. Epub 2022 Jan 19.

Department of Dermatology, Kansas City University Graduate Medical Education Consortium, Advanced Dermatology and Cosmetic Surgery, Orlando, Florida.

View Article and Full-Text PDF

New-onset systemic sclerosis and scleroderma renal crisis under docetaxel.

J Scleroderma Relat Disord 2021 Oct 13;6(3):306-310. Epub 2021 Apr 13.

Department of Medical Oncology, Institut de Cancérologie Strasbourg Europe, Strasbourg, France.

Systemic sclerosis is a rare systemic autoimmune disease characterized by microvascular impairment and fibrosis of the skin and other organs with poor outcomes. Toxic causes may be involved. We reported the case of a 59-year-old woman who developed an acute systemic sclerosis after two doses of adjuvant chemotherapy by docetaxel and cyclophosphamide for a localized hormone receptor + human epithelial receptor 2-breast cancer. Read More

View Article and Full-Text PDF
October 2021

Parry Romberg disease with En Coup de Sabre Scleroderma: Effect of tocilizumab on periodontal bone inflammation.

J Scleroderma Relat Disord 2021 Jun 25;6(2):206-210. Epub 2020 Nov 25.

Pediatric Dermatology Division of the Department of Pediatrics, Federal University of Paraná, Curitiba, Brazil.

Parry Romberg disease and En Coupe de Sabre Scleroderma are frequently associated disorders that affect the face and can cause severe aesthetic and functional impairment. Systemic immunosuppression is the gold standard of first-line treatment in the pediatric rheumatology standpoint although it is often delayed in the pediatric dermatology clinics and more often used in cases of refractory neurological impairment. We report on a case with dental root resorption and severe periodontal bone inflammation detected on magnetic resonance imaging, which was successfully treated with the anti-IL-6 agent tocilizumab. Read More

View Article and Full-Text PDF

DISCERN scores of morphea information on YouTube.

J Dermatolog Treat 2022 Apr 26:1-3. Epub 2022 Apr 26.

Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.

View Article and Full-Text PDF