577 results match your criteria Morganella Infections

and Coinfection in Cobra-Bite Wounds: A Genomic Analysis.

Life (Basel) 2021 Apr 10;11(4). Epub 2021 Apr 10.

Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.

bites cause severe soft tissue injury and are prone to wound infections. The pathogens of bite-wound infections are highly variable in different geographical regions. Here, we report the first coinfection with and from a bite wound with resistome analysis using whole genome sequencing. Read More

View Article and Full-Text PDF

Ceftolozane-tazobactam versus meropenem for definitive treatment of bloodstream infection due to extended-spectrum beta-lactamase (ESBL) and AmpC-producing Enterobacterales ("MERINO-3"): study protocol for a multicentre, open-label randomised non-inferiority trial.

Trials 2021 Apr 22;22(1):301. Epub 2021 Apr 22.

Centre for Clinical Research, Faculty of Medicine, University of Queensland, Royal Brisbane and Women's Hospital Campus, Brisbane, Queensland, Australia.

Background: Extended-spectrum beta-lactamase (ESBL) and AmpC-producing Enterobacterales are common causes of bloodstream infection. ESBL-producing bacteria are typically resistant to third-generation cephalosporins and result in a sizeable economic and public health burden. AmpC-producing Enterobacterales may develop third-generation cephalosporin resistance through enzyme hyper-expression. Read More

View Article and Full-Text PDF

Current antibiotic resistance patterns of rare uropathogens: survey from Central European Urology Department 2011-2019.

BMC Urol 2021 Apr 13;21(1):61. Epub 2021 Apr 13.

Department of Urology, 3rd Faculty of Medicine, Charles University and Thomayer University Hospital, Videnska 800, 140 59, Prague, Czech Republic.

Background: While the resistance rates of commonly detected uropathogens are well described, those of less frequent Gram-negative uropathogenic bacteria have seldom been reported. The aim of this study was to examine the resistance rates of less frequent uropathogenic Gram-negatives in a population of patients treated in a Department of Urology of a tertiary referral centre in Central Europe over a period of 9 years.

Methods: Data on all positive urine samples from urological in- and out-patients were extracted form the Department of Clinical Microbiology database from 2011 to 2019. Read More

View Article and Full-Text PDF

Wound Infections from Taiwan Cobra () Bites: Determining Bacteriology, Antibiotic Susceptibility, and the Use of Antibiotics-A Cobra BITE Study.

Toxins (Basel) 2021 03 2;13(3). Epub 2021 Mar 2.

Department of Emergency Medicine, Lin-Kou Medical Center, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.

Wound necrosis and secondary infection are common complications after bites. Clinical tools to evaluate the infection risk after Taiwan cobra bites are lacking. In this Cobra BITE study, we investigated the prevalence of wound infection, bacteriology, and corresponding antibiotic usage in patients presenting with Taiwan cobra snakebites. Read More

View Article and Full-Text PDF

Use of MALDI-TOF for identification and surveillance of gram-negative bacteria in captive wild psittacines.

Braz J Biol 2021 29;82:e233523. Epub 2021 Mar 29.

Universidade de São Paulo - USP, Departamento de Patologia da Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP, Brasil.

Microbiological studies of the sanitary and health status of psittacine birds that will be reintroduced is important in evaluating whether these animals act as carriers of pathogenic agents to other animals and humans. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a faster and more accurate method to identify bacteria than conventional microbiology methods. The aim of this study was to evaluate the health status of psittacines housed in captivity, by assessment of Gram-negative bacteria from fecal microbiota through MALDI- TOF MS identification. Read More

View Article and Full-Text PDF

Detection of harmful foodborne pathogens in food samples at the points of sale by MALDT-TOF MS in Egypt.

BMC Res Notes 2021 Mar 23;14(1):112. Epub 2021 Mar 23.

Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, 13736, Egypt.

Objectives: Microbes can contaminate foodstuffs resulting in foodborne illnesses. Investigating microbial hazards in foods at the point of sale with rapid tools is required to avoid foodborne illness outbreaks. The current study aimed to identify the microbial hazards in food samples collected from retail shops at sale points using MALDI-TOF MS. Read More

View Article and Full-Text PDF

Managing breast gangrene during the COVID-19 pandemic.

Ann R Coll Surg Engl 2021 May 8;103(5):e141-e143. Epub 2021 Mar 8.

The Royal Marsden NHS Foundation Trust, UK.

At the onset of the COVID-19 crisis, a 63-year-old woman with multiple life-limiting comorbidities was referred with a necrotic infected left breast mass on a background of breast cancer treated with conservation surgery and radiotherapy 22 years previously. The clinical diagnosis was locally advanced breast cancer, but four separate biopsies were non-diagnostic. Deteriorating renal function and incipient sepsis and endocarditis resulted in urgent salvage mastectomy during the peak of the COVID19 pandemic. Read More

View Article and Full-Text PDF

Importance of Reviewing Antibiotic Courses by 48 Hours: Risk Factors for Third-Generation Cephalosporin Resistance Among AmpC Harboring Organisms in Urine and Respiratory Cultures.

Pediatr Infect Dis J 2021 May;40(5):440-445

From the Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, TN.

Background: Citrobacter, Enterobacter, Morganella, and Serratia (AmpC organisms) species can exhibit third-generation cephalosporin (TGC) resistance after TGC exposure. We aimed to assess if institutional TGC utilization correlated with institutional AmpC organism susceptibility and if prior TGC exposure ≤48 hours were associated with TGC resistance in the first culture of a future infection episode caused by an AmpC organism.

Methods: A 5-year retrospective cohort study was performed, including AmpC organisms isolated from pediatric urinary and respiratory tract cultures at an institution with TGC courses reviewed by the antimicrobial stewardship program at 48 hours. Read More

View Article and Full-Text PDF

Emergence of Third-Generation Cephalosporin-Resistant in a Captive Breeding Dolphin in South Korea.

Animals (Basel) 2020 Nov 6;10(11). Epub 2020 Nov 6.

Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.

The emergence of antimicrobial resistant (AMR) strains of is increasingly being recognized. Recently, we reported a fatal infection in a captive bottlenose dolphin () bred at a dolphinarium in South Korea. According to our subsequent investigations, the isolated strain KC-Tt-01 exhibited extensive resistance to third-generation cephalosporins which have not been reported in animals. Read More

View Article and Full-Text PDF
November 2020

[Infections by OXA-48 carbapenemase-producing Enterobacteriaceae in surgical patients: antibiotic consumption and susceptibility patterns].

Rev Esp Quimioter 2020 Dec 16;33(6):448-452. Epub 2020 Oct 16.

Ismael Mora Guzmán, Servicio de Cirugía General y del Aparato Digestivo. Hospital General La Mancha Centro. Avda. de la Constitución, 3. 13600-Alcázar de San Juan (Ciudad Real). Spain.

Objective: To assess antibiotic consumption, susceptibility patterns and targeted treatment for OXA-48 carbapenemase-producing Enterobacteriaceae (CPE) related infections in surgical patients in a General Surgery Department.

Methods: Retrospective review of patients with a positive culture for OXA-48 and associated clinical data of infection, while hospitalized in a General Surgery Department from January 2013 to December 2018.

Results: Sixty-five patients with 66 isolations (OXA-48) were included: Klebsiella pneumoniae, 57 (86. Read More

View Article and Full-Text PDF
December 2020

Exploring Antimicrobial Resistance in Agents Causing Urinary Tract Infections at a Tertiary Care Hospital in a Developing Country.

Cureus 2020 Aug 14;12(8):e9735. Epub 2020 Aug 14.

Urology, Rawalpindi Medical University, Rawalpindi, PAK.

Background and objective Urinary tract infections (UTIs) are usually treated with empirical therapy by physicians based on previous knowledge of the predictability of causative agents and their antimicrobial susceptibilities. The objective of this study was to determine the frequency of various pathogens causing UTIs and their antimicrobial resistance profile in patients presenting to the outpatient department (OPD) of a tertiary care hospital. Materials and methods This descriptive cross-sectional study was conducted in the urology OPD of a tertiary care hospital in Pakistan. Read More

View Article and Full-Text PDF

Primary intestinal lymphangiectasia diagnosed by video capsule endoscopy in a patient with immunodeficiency presenting with bacteraemia.

BMJ Case Rep 2020 Sep 13;13(9). Epub 2020 Sep 13.

Division of Gastroenterology and Hepatology, Denver Health and Hospital Authority, Denver, Colorado, USA.

A 24-year-old woman with a medical history of chronic lower extremity oedema, abdominal pain, diarrhoea and recurrent pulmonary infections presented with sepsis from right lower extremity cellulitis. Blood cultures grew Laboratory evaluation revealed lymphopaenia, hypogammaglobulinaemia, a low CD4+ T-cell count and nutritional deficiencies resulting from protein-losing enteropathy (PLE). CT showed small bowel wall thickening in the jejunum and ileum. Read More

View Article and Full-Text PDF
September 2020

Wound Infections of Snakebites from the Venomous and in Taiwan: Bacteriology, Antibiotic Susceptibility, and Predicting the Need for Antibiotics-A BITE Study.

Toxins (Basel) 2020 09 7;12(9). Epub 2020 Sep 7.

Department of Emergency Medicine, Lin-Kou Medical Center, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.

Snakebites from Taiwan habus () and green bamboo vipers () account for two-thirds of all venomous snakebites in Taiwan. While there has been ongoing optimization of antivenin therapy, the proper management of superimposed bacterial wound infections is not well studied. In this Bacteriology of Infections in Taiwanese snake Envenomation (BITE) study, we investigated the prevalence of wound infection, bacteriology, and corresponding antibiotic usage in patients presenting with snakebites from these two snakes. Read More

View Article and Full-Text PDF
September 2020

Subdural empyema caused by .

Surg Neurol Int 2020 1;11:216. Epub 2020 Aug 1.

Department of Neurological Surgery, University of Wisconsin-Madison, Madison, Wisconsin, United States.

Background: is a species of Gram-negative enteric rod found in normal human gut flora. Pathologically, this most often presents as urinary tract infections, wound infections, and bacteremia. It is highly uncommon for to be implicated in a central nervous system infection, with only 12 reported cases of parenchymal abscesses or meningitis. Read More

View Article and Full-Text PDF

Sequencing of five poultry strains elucidates phylogenetic relationships and divergence in virulence genes in Morganella morganii.

BMC Genomics 2020 Aug 24;21(1):579. Epub 2020 Aug 24.

Clinic for Poultry and Fish Medicine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Veterinärplatz 1, 1210, Vienna, Austria.

Background: M. morganii is a bacterium frequently associated with urinary infections in humans. While many human strains are sequenced, only the genomes of few poultry strains are available. Read More

View Article and Full-Text PDF

Conjugative plasmidic AmpC detected in Escherichia coli, Proteus mirabilis and Klebsiella pneumoniae human clinical isolates from Portugal.

Braz J Microbiol 2020 Dec 1;51(4):1807-1812. Epub 2020 Aug 1.

Laboratory of Biological Science 18.P5.E3, Faculty of Pharmacy of Universidade do Porto Porto and UCIBIO, Jorge Viterbo Ferreira, 228, Porto, Portugal.

AmpC is a type of β-lactamase enzyme produced by bacteria; these enzymes are classified in Class C and Group 1, and these confer resistance to cephamycin. Enterobacterales producing AmpC are reported worldwide and have great clinical importance due to therapeutic restriction and epidemiological importance once the easy dissemination by plasmidic genes to other bacteria is a real threat. These genes are naturally found in some enterobacteria as Enterobacter cloacae, Morganella morganii, and Citrobacter freundii, but other species have demonstrated similar resistance phenotype of AmpC production. Read More

View Article and Full-Text PDF
December 2020

Rapid screening and characterization of bacteria associated with hospital cockroaches (Blattella germanica L.) using MALDI-TOF mass spectrometry.

J Appl Microbiol 2021 Mar 14;130(3):960-970. Epub 2020 Aug 14.

Department of Biochemistry, Faculty of Science, University Badji Mokhtar Annaba, Annaba, Algeria.

Aims: The study aimed to explore the diversity of culturable microbiota colonizing the alimentary tract and outer surfaces of German cockroaches (Blattella germanica) captured in a health care facility.

Methods And Results: Microbial identification was conducted using Matrix Assisted Laser Desorption-Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) Biotyper and 16S rRNA sequencing. A total of 181 bacteria strains were isolated from 25 cockroach specimens and the MALDI-TOF MS-based assay yielded direct identification of 96·5% (175 out of 181) of the strains at the species level. Read More

View Article and Full-Text PDF

Cefiderocol, a New Siderophore Cephalosporin for the Treatment of Complicated Urinary Tract Infections Caused by Multidrug-Resistant Pathogens: Preclinical and Clinical Pharmacokinetics, Pharmacodynamics, Efficacy and Safety.

Clin Drug Investig 2020 Oct;40(10):901-913

Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA.

Cefiderocol (Fetroja) is a siderophore cephalosporin and has demonstrated potent activity against extended-spectrum beta-lactamases producing Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae, and nonfermenting Gram-negative bacilli, including Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter baumannii, Burkholderia cepacia, and Klebsiella pneumoniae. However, cefiderocol has limited activity against Gram-positive bacteria and anaerobes like Bacterodies fragilis. In the APEKS-cUTI study, 183 (73%) of 252 patients in the cefiderocol group versus 65 (55%) of 119 patients in the imipenem-cilastatin group achieved the composite outcome of clinical and microbiological eradication of Gram-negative bacteria (treatment difference of 18. Read More

View Article and Full-Text PDF
October 2020

Depicting SARS-CoV-2 faecal viral activity in association with gut microbiota composition in patients with COVID-19.

Gut 2021 02 20;70(2):276-284. Epub 2020 Jul 20.

Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China

Objective: Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was detected in faeces of patients with COVID-19, the activity and infectivity of the virus in the GI tract during disease course is largely unknown. We investigated temporal transcriptional activity of SARS-CoV-2 and its association with longitudinal faecal microbiome alterations in patients with COVID-19.

Design: We performed RNA shotgun metagenomics sequencing on serial faecal viral extractions from 15 hospitalised patients with COVID-19. Read More

View Article and Full-Text PDF
February 2021

Identification of enterobacteria in viscera of pigs afflicted with porcine reproductive and respiratory syndrome and other viral co-infections.

Microb Pathog 2020 Oct 11;147:104385. Epub 2020 Jul 11.

Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, 330045, China. Electronic address:

In order to investigate enterobacteria presence involved in the secondary infections in Porcine Reproductive and Respiratory Syndrome (PRRS) pigs with different viral co-infections, we identified enterobacteria for guiding clinical treatment. Twenty-one diseased pigs were diagnosed with the PRRS virus (PRRSV) and other 7 virus primers by PCR/RT-PCR in the lung and spleen samples. Enterobacteria were isolated using MacConkey agar from 5 visceral samples of PRRS pigs, and identified by 16S rDNA sequencing. Read More

View Article and Full-Text PDF
October 2020

Molecular basis of the beta-lactamase protein using comparative modelling, drug screening and molecular dynamics studies to understand the resistance of β-lactam antibiotics.

Meshari Alazmi

J Mol Model 2020 Jul 7;26(8):200. Epub 2020 Jul 7.

Department of Computer Science, College of Computer Science and Engineering, University of Ha'il, P.O. Box 2440, Ha'il, 81481, Saudi Arabia.

Beta-lactamase (ampC) in general causes the onset of antibiotic resistance in pathogenic bacteria against the β-lactam antibiotics. Morganella morganii which belongs to the Proteae tribe of the Enterobacteriaceae family is a Gram-negative bacillus. Gram-negative bacteria are the key problematic agents among the human population in overexpressing resistance against β-lactam antibiotics. Read More

View Article and Full-Text PDF

Efficacy of Ceftazidime-avibactam Plus Aztreonam in Patients With Bloodstream Infections Caused by Metallo-β-lactamase-Producing Enterobacterales.

Clin Infect Dis 2021 Jun;72(11):1871-1878

Department of Clinical and Experimental Medicine, Infectious Diseases Unit, University of Pisa, Pisa, Italy.

Background: In vitro data support the use of combination of aztreonam (ATM) with ceftazidime-avibactam (CAZ-AVI), but clinical studies are lacking. The aim of our study was to compare the outcome of patients with bloodstream infections (BSIs) due to metallo-β-lactamase (MBL)-producing Enterobacterales treated either with CAZ-AVI plus ATM or other active antibiotics (OAAs).

Methods: This was a prospective observational study including patients admitted to 3 hospitals in Italy and Greece. Read More

View Article and Full-Text PDF

Trends in Distribution and Antibiotic Resistance of Bacteria Isolated from Urine Cultures of Children in Northern Israel Between 2010 and 2017.

Microb Drug Resist 2020 Nov 14;26(11):1342-1349. Epub 2020 May 14.

The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

To identify the changing trends of uropathogens over the years 2010-2017 and examine the incidence of both antibiotic resistance and extended spectrum beta lactamases (ESBL)-producing Enterobacteriaceae in urine cultures from pediatric patients. Electronic medical records of 1,056 children, admitted to the Poriya Medical Center in Israel, between 2010 and 2017 with positive urine cultures, were reviewed for bacterial species and antibiotics resistance. The leading pathogen was (76%), followed by (7%), (5. Read More

View Article and Full-Text PDF
November 2020

[Aerobic bacteria from skin lesions in reptiles and their antimicrobial susceptibility].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2020 Apr 23;48(2):78-88. Epub 2020 Apr 23.

LABOKLIN GmbH & Co. KG, Bad Kissingen.

Objective: Bacterial skin infections are common in reptiles. Although many such infections are influenced by multifactorial problems, specific treatment of bacterial infections is an important consideration. The objective of this study was to evaluate the range of aerobic bacteria in skin lesions of reptiles and to determine their antimicrobial susceptibility. Read More

View Article and Full-Text PDF

Antimicrobial susceptibility and distribution of extended-spectrum β-lactamases, AmpC β-lactamases and carbapenemases among Proteus, Providencia and Morganella isolated from global hospitalised patients with intra-abdominal and urinary tract infections: Results of the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2008-2011.

J Glob Antimicrob Resist 2020 09 18;22:398-407. Epub 2020 Apr 18.

Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Objectives: The increasing trend of β-lactam resistance among Enterobacteriaceae is a worldwide problem. This study investigated isolates of the tribe Proteeae (Proteus, Providencia and Morganella) causing intra-abdominal and urinary tract infections from the worldwide Study for Monitoring Antimicrobial Resistance Trends (SMART) collected from 2008-2011.

Methods: Antimicrobial susceptibility testing was performed on isolates with an ertapenem minimum inhibitory concentration >0. Read More

View Article and Full-Text PDF
September 2020

A Case of Morganella morganii-induced Fetal Demise.

Cureus 2020 Mar 3;12(3):e7169. Epub 2020 Mar 3.

Internal Medicine, Marshall University, Huntington, USA.

Morganella morganii is a rare opportunistic pathogen that is known to cause urinary tract and intra-abdominal infections. Per our literature review, there are few case reports of neonatal sepsis associated with this organism but to our knowledge, there are no case reports of Morganella morganii causing fetal demise in published literature in the Englishlanguage. In this case report, we present a case of a 34-year-old pregnant woman who had a hospital course complicated by Morganella morganii, which eventually led to stillbirth. Read More

View Article and Full-Text PDF

Phytochemical screening, antioxidant and antibacterial properties of daphne mucronata.

J Tradit Chin Med 2019 12;39(6):764-771

Centre of Biotechnology and Microbiology, University of Peshawar, Peshawar 25000, Pakistan.

Objective: To aim at preliminary phytochemical screening of Daphne mucronata and evaluate its antioxidant and antibacterial activities.

Methods: Preliminary phytochemical screening was conducted for the crude extracts using standard methods. Antioxidant properties of crude methanolic extracts, n-hexane, chloroform, ethyl acetate and aqueous fractions of leaves, roots and bark were evaluated following standard procedures. Read More

View Article and Full-Text PDF
December 2019

Ringing bells: Morganella morganii fights for recognition.

Altaf Bandy

Public Health 2020 May 11;182:45-50. Epub 2020 Mar 11.

College of Medicine, Jouf University, PO Box: 2014, Sakaka, Al Jouf, Saudi Arabia. Electronic address:

Objectives: The global increase in rare opportunistic microbial infections is alarming. The current review was undertaken to study the diversified disease spectrum, pathogenicity, and resistance patterns of Morganella morganii.

Study Design: This study is a review of the diversified disease spectrum of M. Read More

View Article and Full-Text PDF

Whole genome sequencing provides genomic insights into three Morganella morganii strains isolated from bovine rectal swabs in Dhaka, Bangladesh.

FEMS Microbiol Lett 2020 03;367(6)

NSU Genome Research Institute (NGRI), North South University, Dhaka, Bangladesh.

Morganella morganii, a gram negative, facultative anaerobic bacterium belonging to the Proteeae tribe of the Morganellaceae family, is an unusual opportunistic pathogen mainly responsible for nosocomial and urinary tract infections. While cattle have long been established as a source of a few zoonotic pathogens, no such data has been recorded for M. morganii despite its ubiquitous presence in nature and a number of animal hosts. Read More

View Article and Full-Text PDF

Highly multidrug-resistant clinical isolates from Nepal co-producing NDM-type metallo-β-lactamases and the 16S rRNA methylase ArmA.

J Med Microbiol 2020 Apr;69(4):572-575

Department of Microbiology, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

can harbour extended-spectrum β-lactamases and carbapenemases, resulting in increased resistance to multiple antibiotics and a high mortality rate. This study describes the emergence of highly multidrug-resistant clinical isolates of from Nepal co-producing NDM-type metallo-β-lactamases, including NDM-1 and NDM-5, and the 16S rRNA methylase ArmA. This is the first report of clinical isolates from Nepal co-producing NDM-1/-5 and ArmA. Read More

View Article and Full-Text PDF