1,155 results match your criteria Morganella Infections


SuperPolymyxin™ Medium for the Screening of Colistin-Resistant Gram-Negative Bacteria in Stool Samples.

Front Microbiol 2018 21;9:2809. Epub 2018 Nov 21.

Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.

Colistin is one of the last resort antimicrobials for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. After the emergence of transferable colistin resistance genes (-1-5), a reliable culture-based screening method to detect colonization with colistin-resistant Gram-negative bacteria (CRGN) is needed. The objective of this study was to test the performance of SuperPolymyxin™ medium to screen for CRGN in stool samples and to compare different methods for the confirmation of colistin resistance (e. Read More

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November 2018

A novel cfr-carrying Tn7 transposon derivative characterized in Morganella morganii of swine origin in China.

J Antimicrob Chemother 2018 Nov 30. Epub 2018 Nov 30.

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan Province, People's Republic of China.

Objectives: To characterize the presence and genetic environment of the multiresistance gene cfr in bacterial isolates from a swine farm.

Methods: A total of 97 bacterial isolates, recovered from 32 faecal swabs obtained on one farm, were tested for the presence of the cfr gene by PCR. Species identification of the one cfr-positive strain was conducted using the BD PhoenixTM 100 Automated Microbiology System. Read More

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November 2018

Ciprofloxacin Promoted qnrD Expression and Phylogenetic Analysis of qnrD Harboring Plasmids.

Microb Drug Resist 2018 Nov 21. Epub 2018 Nov 21.

1 Institute of Medical Microbiology, Semmelweis University , Budapest, Hungary .

Morganella morganii SE10MM harboring quinolone resistance determinant qnrD was investigated in our study. An entirely sequenced novel 2,662 bp qnrD-plasmid pSE10MM was identified and deposited at GenBank under accession number KU160530. Nucleic acid sequence of pSE10MM showed 94-97% similarity to previously detected qnrD-plasmids of Proteus mirabilis strains. Read More

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November 2018
2 Reads

Activity of Plazomicin against Gram-negative and Gram-positive Bacterial Pathogens Isolated from Patients in Canadian Hospitals from 2013 to 2017: CANWARD Surveillance Study.

Antimicrob Agents Chemother 2018 Oct 29. Epub 2018 Oct 29.

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada.

The Clinical and Laboratory Standards Institute (CLSI) broth microdilution method was used to evaluate the activities of plazomicin and comparator antimicrobial agents against 7,712 Gram-negative and 4,481 Gram-positive bacterial pathogens obtained from patients in Canadian hospitals (CANWARD, 2013 to 2017). Plazomicin demonstrated potent activity against (MIC ≤1 µg/ml for all species tested except and ), including aminoglycoside non-susceptible, extended-spectrum β-lactamase (ESBL)-positive, and multidrug-resistant (MDR) isolates. Plazomicin was equally active against methicillin-susceptible and methicillin-resistant isolates of . Read More

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October 2018
3 Reads

Emergence of Morganella morganii subsp. morganii in dairy calves, China.

Emerg Microbes Infect 2018 Oct 24;7(1):172. Epub 2018 Oct 24.

College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, PR China.

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October 2018
1 Read

Filamentous gram-negative bacteria masquerading as actinomycetes in infectious endophthalmitis: a review of three cases.

J Ophthalmic Inflamm Infect 2018 Oct 11;8(1):15. Epub 2018 Oct 11.

Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L. V. Prasad Eye Institute, Hyderabad, India.

Background: To report microbiological diagnostic dilemma posed by observation of unusual morphology of bacteria in the vitreous sample of a series of three cases of bacterial endophthalmitis.

Results: A non-comparative, descriptive case series is described. All three cases presented to the retina-vitreous clinic with a clinical diagnosis of acute endophthalmitis between January and April 2018. Read More

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October 2018
3 Reads

Alterations of the Gut Microbiome Associated With the Treatment of Hyperuricaemia in Male Rats.

Front Microbiol 2018 19;9:2233. Epub 2018 Sep 19.

Institute of Basic Research in Clinical Medicine, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, China.

Hyperuricaemia is an important risk factor for many diseases including gout, hypertension, and type II diabetes. The gut microbiota is associated with hyperuricaemia and has also been demonstrated to play significant roles in the effects of drug therapy. This study used Illumina MiSeq sequencing to explore alterations of the gut microbiome associated with allopurinol and benzbromarone treatment in the male rat with hyperuricaemia. Read More

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September 2018
7 Reads

Development and evaluation of an improved quantitative loop-mediated isothermal amplification method for rapid detection of Morganella morganii.

Talanta 2019 Jan 13;191:54-58. Epub 2018 Aug 13.

Faculty of Biological Sciences & Technology, Shahid Beheshti University, G.C., Tehran 1983969411, Iran.

A point-of-care diagnostic kit was developed for detection of Morganella morganii using optimized loop-mediated isothermal amplification (LAMP) technique within less than an hour. In that regard, dimethyl sulfoxide (DMSO) was utilized together with betaine and all variables were optimized to improve the efficiency of the method. Moreover, surface presentation of antigens protein was targeted and six unique primers were designed. Read More

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January 2019
5 Reads

Oral Microbiota of the Snake in Martinique.

Int J Environ Res Public Health 2018 09 27;15(10). Epub 2018 Sep 27.

Intensive Care Unit, University Hospital of Martinique, Fort-de-France, 97200 Martinique, France.

In Martinique, snakebite, although relatively uncommon (~30 cases/year), may result in serious complications such as systemic thrombosis and local infections. Infections have been hypothesized to be related to bacteria present in the snake's oral cavity. In this investigation, we isolated, identified, and studied the susceptibility to beta-lactams of bacteria sampled from the oral cavity of twenty-six specimens collected from various areas in Martinique. Read More

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September 2018
11 Reads

Incidence of antibiogram, antibiotic resistance genes and class 1 and 2 integrons in tribe Proteeae with IMP27 gene for the first time in Providencia sp. isolated from pet turtles.

Lett Appl Microbiol 2018 Dec 12;67(6):620-627. Epub 2018 Nov 12.

Laboratory of Aquatic Animal Medicine, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Korea.

Proteeae is a tribe which consists of three genera: Proteus, Providencia and Morganella. The objective of this study was to determine antimicrobial resistance profile, virulence genotype and class 1 and 2 integrons in Proteeae isolated from pet turtles and to determine the impact of antibiotic resistance on virulence and antimicrobial resistance genes. Integron-positive isolates were used to detect their gene cassette array. Read More

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December 2018
1 Read

qnrD-harboring plasmids in Providencia spp. recovered from food and environmental Brazilian sources.

Sci Total Environ 2019 Jan 27;646:1290-1292. Epub 2018 Jul 27.

Laboratório de Investigação em Microbiologia Médica (LIMM), Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

QnrD is a plasmid-mediated quinolone resistance (PMQR) determinant first reported in clinical Salmonella enterica isolates from China, located on nonconjugative plasmids of 4270 bp. Since then, the qnrD gene has been mostly found on plasmids around 2683 bp in Proteus and Morganella genera. However, Providencia spp. Read More

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January 2019

Poisoning with Soman, an Organophosphorus Nerve Agent, Alters Fecal Bacterial Biota and Urine Metabolites: a case for Novel Signatures for Asymptomatic Nerve Agent Exposure.

Appl Environ Microbiol 2018 Sep 14. Epub 2018 Sep 14.

Integrative Systems Biology Program, US Army Center for Environmental Health Research, Fort Detrick, Maryland

The experimental pathophysiology of organophosphorus (OP) chemical exposure has been extensively reported. Here, we describe an altered fecal bacterial biota and urine metabolome that follows intoxication with soman, a lipophilic G class chemical warfare nerve agent. Non-anaesthetized Sprague-Dawley male rats were subcutaneously administered soman at 0. Read More

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September 2018
1 Read

First report of blaOXA-24 carbapenemase-encoding gene, armA Methyltransferase and aac(6)-Ib-cr producing multidrug-resistant clinical isolates of Proteus mirabilis in Algeria.

J Glob Antimicrob Resist 2018 Sep 11. Epub 2018 Sep 11.

Unité de recherche sur les maladies infectieuses et tropicales émergentes, URMITE CNRS-IRD, UMR 6236, Méditerranée infection, Faculté de Médecine et de Pharmacie, Aix-Marseille-Université, Marseille, France. Electronic address:

Background: Carbapenemase-producing, or carbapenem-resistant Enterobacteriaceae, are an emerging threat to human and animal health because they are resistant to many of the last-line antimicrobials available for disease treatment. The aim of this study was to analyze antimicrobial resistance patterns and their encoding genes of P. mirabilis isolated in Constantine, Algeria. Read More

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September 2018
12 Reads

Antibiotic susceptibility of wound swab isolates in a tertiary hospital in Southwest Nigeria.

Ann Afr Med 2018 Jul-Sep;17(3):110-116

Department of Medical Microbiology and Parasitology, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.

Background: Wounds are commonly encountered in the clinical practice. Microbacterial colonization and infection negatively affect wound outcomes. With increasing emergence of antibiotic-resistant strains, it is essential to determine local patterns of wound microbiological profile and antibiotic susceptibility to guide rational empirical antibiotic use. Read More

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September 2018

Molecular Characterization of Histamine-Producing Psychrotrophic Bacteria Isolated from Red Octopus () in Refrigerated Storage.

High Throughput 2018 Sep 4;7(3). Epub 2018 Sep 4.

Experimental Unit, University Marist of Mérida, Periférico Norte Tablaje Catastral 13941, Carretera Mérida-Progreso, Mérida 97300, Yucatán, México.

The present study aimed at determining the histamine production capacity of Gram (+) and Gram (-) bacteria isolated from , along with identifying the presence of amino acid decarboxylase genes. Of the total 80 psychrotrophic microorganisms, 32 strains were identified as histamine-forming bacteria. The recombinant DNA technique was used for genotypic identification of histidine (), ornithine (), and lysine decarboxylases () genes. Read More

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September 2018

Development of a molecular serotyping scheme and a multiplexed luminex-based array for Providencia.

J Microbiol Methods 2018 Oct 20;153:14-23. Epub 2018 Aug 20.

Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Tianjin Economic-Technological Development Area, Tianjin, China; TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin Economic-Technological Development Area, Tianjin, China; Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin Economic-Technological Development Area, Tianjin, China. Electronic address:

Providencia is an opportunistic human pathogen that belongs to the Enterobacteriaceae family. The bacterial cell surface O-antigen is one of the most structurally variable cell constituents and serves as a basis for serotyping gram-negative bacteria. In this work, the genomes of 12 Providencia strains were sequenced, and genes driving O-antigen biosynthesis were analyzed. Read More

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October 2018
4 Reads

Noncanonical secondary structures arising from non-B DNA motifs are determinants of mutagenesis.

Genome Res 2018 09 13;28(9):1264-1271. Epub 2018 Aug 13.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, United Kingdom.

Somatic mutations show variation in density across cancer genomes. Previous studies have shown that chromatin organization and replication time domains are correlated with, and thus predictive of, this variation. Here, we analyze 1809 whole-genome sequences from 10 cancer types to show that a subset of repetitive DNA sequences, called non-B motifs that predict noncanonical secondary structure formation can independently account for variation in mutation density. Read More

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September 2018

Screening of microbial communities associated with endive lettuce during postharvest processing on industrial scale.

Heliyon 2018 Jul 11;4(7):e00671. Epub 2018 Jul 11.

Leibniz Institute for Agricultural Engineering and Bioeconomy (ATB), Quality and Safety of Food and Feed, Department of Horticultural Engineering, Max-Eyth-Allee 100, 14469 Potsdam, Germany.

In this study, the composition of the microbial community on endive lettuce () was evaluated during different postharvest processing steps. Microbial community structure was characterized by culture-dependent and culture-independent methods. Endive lettuce was sampled exemplarily at four different stages of processing (raw material, cut endive lettuce, washed endive lettuce, and spin-dried (ready to pack) endive lettuce) and analysed by plate count analysis using non-selective and selective agar plates with subsequent identification of bacteria colonies by matrix-assisted laser desorption/ionization time-of light mass spectrometry (MALDI-TOF MS). Read More

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July 2018
1 Read

Considerations for Systemic and Topical Treatment of Morganella morganii Septicemia Arising from Maggot Infestation.

Wounds 2018 Jun;30(6):E60-E64

West Virginia University School of Medicine, Morgantown, WV.

Introduction: Live maggot infestation (myiasis) of wounds can present a host of ailments. Loosely associated with maggot excreta, Morganella morganii is a widespread, gram-negative rod bacterium commonly found in the intestinal tracts of humans. M morganii has been observed as being pathogenic, particularly in nosocomial and postoperative environments, as well as in immunosuppressed and elderly populations. Read More

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June 2018
10 Reads

The fly factor phenomenon is mediated by interkingdom signaling between bacterial symbionts and their blow fly hosts.

Insect Sci 2018 Jul 26. Epub 2018 Jul 26.

Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.

We tested the recent hypothesis that the "fly factor" phenomenon (food currently or previously fed on by flies attracts more flies than the same type of food kept inaccessible to flies) is mediated by bacterial symbionts deposited with feces or regurgitated by feeding flies. We allowed laboratory-reared black blow flies, Phormia regina (Meigen), to feed and defecate on bacterial Luria-Bertani medium solidified with agar, and isolated seven morphologically distinct bacterial colonies. We identified these using matrix-assisted laser desorption/ionization mass spectrometry and sequencing of the 16S rRNA gene. Read More

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July 2018
15 Reads

Failure of a multiplex polymerase chain reaction assay to detect IMP-27 in a clinical isolate of Morganella morganii.

Diagn Microbiol Infect Dis 2018 Nov 22;92(3):194-195. Epub 2018 Jun 22.

Department of Medical Microbiology & Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada; Diagnostic Services Manitoba, Winnipeg, Manitoba, Canada.

A case of an IMP-27-positive Morganella morganii isolate is reported, where the carbapenemase enzyme was demonstrated by whole genome sequencing. Carbapenemase detection using a multiplex PCR assay was negative due to mutations in the primer binding site. This case serves to illustrate the limitations of multiplex PCR for carbapenemase detection. Read More

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November 2018

Gut Bacterial Diversity of Insecticide-Susceptible and -Resistant Nymphs of the Brown Planthopper Stål (Hemiptera: Delphacidae) and Elucidation of Their Putative Functional Roles.

J Microbiol Biotechnol 2018 Jun;28(6):976-986

Department of Environmental and Biological Chemistry, Chungbuk National University, Cheongju 28644, Republic of Korea.

Knowledge about the gut bacterial communities associated with insects is essential to understand their roles in the physiology of the host. In the present study, the gut bacterial communities of a laboratory-reared insecticide-susceptible (IS), and a field-collected insecticide-resistant (IR) population of a major rice pest, the brown planthopper , were evaluated. The deep-sequencing analysis of the V3 hypervariable region of the 16S rRNA gene was performed using Illumina and the sequence data were processed using QIIME. Read More

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June 2018
10 Reads
1.520 Impact Factor

Prevalence of extended spectrum beta lactamase and plasmid mediated quinolone resistant genes in strains of and isolated from poultry in South Western Nigeria.

PeerJ 2018 22;6:e5053. Epub 2018 Jun 22.

Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.

A serious concern is arising on the coexistence of extended-spectrum beta-lactamase (ESBL) and plasmid mediated quinolone resistance (PMQR) producing bacteria in animal husbandry, which could be transferred to humans, especially in strains that may not be routinely screened for resistance. This study therefore tested the prevalence of ESBL and PMQR genes in selected bacteria isolated from poultry faeces. Faecal droppings of birds were collected from 11 farms in five states in South Western Nigeria. Read More

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June 2018
1 Read

Cultivable bacteria from Pectinatella magnifica and the surrounding water in South Bohemia indicate potential new Gammaproteobacterial, Betaproteobacterial and Firmicutes taxa.

FEMS Microbiol Lett 2018 Jul;365(13)

Department of Microbiology, Nutrition and Dietetics, Czech University of Life Sciences Prague, Kamýcká 129, Prague 6, Suchdol 165 00, Czech Republic.

Pectinatella magnifica is a freshwater bryozoan, which has become a subject of scientific interest because of its invasive expansion worldwide. To obtain a comprehensive overview of its influence on environments, information on associated bacteria is needed. In this study, cultivable bacteria associated with P. Read More

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July 2018
27 Reads

Characteristics of Surgical Site Infection Following Colorectal Surgery in a Tertiary Center: Extended-spectrum β-Lactamase-producing Bacteria Culprits in Disease.

Wounds 2017 12;30(4):108-113

Department of Colorectal Surgery, Chelsea and Westminster Hospital, London, UK; and The Royal Marsden NHS Foundation Trust, London, UK.

Introduction: Surgical site infection (SSI) is a well-known complication of colorectal surgery associated with increased morbidity and hospital stay. Antimicrobial prophylaxis can reduce the risk of SSI by as much as 75%. Extended-spectrum β-lactamase (ESBL)-producing pathogens make the successful use of such prophylaxis a challenge and are a real threat to patient care following colorectal surgery. Read More

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December 2017
39 Reads

Efflux pump inhibitor CCCP to rescue colistin susceptibility in mcr-1 plasmid-mediated colistin-resistant strains and Gram-negative bacteria.

J Antimicrob Chemother 2018 Apr 26. Epub 2018 Apr 26.

Aix Marseille Univ, IRD, APHM, MEPHI, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille cedex 05, France.

Objectives: Efflux in bacteria is a ubiquitous mechanism associated with resistance to antimicrobials agents. Efflux pump inhibitors (EPIs) have been developed to inhibit efflux mechanisms and could be a good alternative to reverse colistin resistance, but only CCCP has shown good activity. The aim of our study was to identify CCCP activity in a collection of 93 Gram-negative bacteria with known and unknown colistin resistance mechanisms including isolates with mcr-1 plasmid-mediated colistin resistance. Read More

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April 2018
4 Reads

Novel class 1 integron (In1390) harboring bla in a Morganella morganii strain recovered from a remote community.

Diagn Microbiol Infect Dis 2018 Aug 10;91(4):345-347. Epub 2018 Mar 10.

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address:

Antimicrobial resistance in Morganella morganii has been mainly acquired via plasmids and class 1 integrons. We hereby report acquisition of bla by a M. morganii isolated in a remote community from the Amazon region. Read More

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August 2018
2 Reads

Dissemination of KPC-2-Encoding IncX6 Plasmids Among Multiple Species in a Single Chinese Hospital.

Front Microbiol 2018 19;9:478. Epub 2018 Mar 19.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.

Forty-five KPC-producing strains were isolated from multiple departments in a Chinese public hospital from 2014 to 2015. Genome sequencing of four representative strains, namely GN2, GN26, GN28, and E20, indicated the presence of -carrying IncX6 plasmids pGN2-KPC, pGN26-KPC, pGN28-KPC, and pE20-KPC in the four strains, respectively. These plasmids were genetically closely related to one another and to the only previously sequenced IncX6 plasmid, pKPC3_SZ. Read More

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March 2018
7 Reads

Early Bacterial Pneumonia After Hepatic Transplantation: Epidemiologic Profile.

Transplant Proc 2018 Mar;50(2):503-508

Programa Nacional de Trasplante Hepático, Unidad Bi-Institucional de Enfermedades Hepáticas Compleja (Hospital Militar, Hospital de Clínicas), Cátedra de Enfermedades Infecciosas, Facultad de Medicina Montevideo, UdeLaR, Montevideo, Uruguay.

Background: Postoperative pulmonary complications are major cause of morbidity and mortality in patients receiving liver transplantation (LT), particularly bacterial pneumonia occurring within the first 100 days after transplantation. Our aim in this study was to determine the incidence, microorganisms involved, associated factors, and morbidity of bacterial pneumonia presenting in the first 100 days posttransplant.

Methods: We performed a cohort study in which patients receiving liver transplantation were included prospectively in our national database (Database of Infections in Transplantation of Solid Organs). Read More

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March 2018
3 Reads

Activity of omadacycline tested against Enterobacteriaceae causing urinary tract infections from a global surveillance program (2014).

Diagn Microbiol Infect Dis 2018 Jun 24;91(2):179-183. Epub 2018 Feb 24.

JMI Laboratories, North Liberty, Iowa, USA.

Omadacycline is an aminomethylcycline with in vitro activity against many gram-negative pathogens. Omadacycline and comparators were tested against Enterobacteriaceae from urinary tract infections (UTIs) selected from a 2014 global surveillance program and compared to results of isolates from 2010 surveillance. The omadacycline MIC for Enterobacteriaceae collected during 2014 was 2/≥8 μg/mL (1/4 μg/mL minus Proteus, Providencia, and Morganella spp. Read More

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June 2018
5 Reads

Genetic contexts related to the diffusion of plasmid-mediated CTX-M-55 extended-spectrum beta-lactamase isolated from Enterobacteriaceae in China.

Ann Clin Microbiol Antimicrob 2018 Mar 23;17(1):12. Epub 2018 Mar 23.

Department of Clinical Laboratory, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Background: CTX-M-55 extended-spectrum beta-lactamases are being rapidly disseminated and transmitted in clinical practices around the world. The genetic contexts of the transferable plasmid-mediated bla gene in Enterobacteriaceae were detected and characterized in this study.

Methods: Isolates were obtained from the First Affiliated Hospital of Zhengzhou University between September 2015 and March 2016. Read More

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March 2018
7 Reads

Species-specific mutation rates for ampC derepression in Enterobacterales with chromosomally encoded inducible AmpC β-lactamase.

J Antimicrob Chemother 2018 Jun;73(6):1530-1536

Department of Medical Microbiology, Ruhr-Universität Bochum, Universitätsstraße 150, 44801 Bochum, Germany.

Background: AmpC β-lactamases are encoded on the chromosomes of certain Enterobacterales and lead to clinical resistance to various β-lactams in case of high-level expression. In WT bacteria with inducible AmpC, the expression is low, but selection of stably ampC-derepressed mutants may occur during β-lactam therapy. Thus, for Enterobacter spp. Read More

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First report of genital ulcer due to Morganella morganii infection.

G Ital Dermatol Venereol 2018 Apr;153(2):291-293

DISSAL Department of Dermatology, IRCCS A.O.U. San Martino-IST, Genoa, Italy.

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April 2018
1 Read

Biosynthetic graft failure to replace infected infrainguinal bypass as developing infection due to Morganella morganii leading to disrupture of the anastomosis. Case report.

Int J Surg Case Rep 2017 12;41:411-413. Epub 2017 Nov 12.

Unit of Vascular and Endovascular Surgery, University Hospital of Ferrara, Italy. Electronic address:

Introduction: Biosynthetic prosthesis has become the trend to carry out arterial reconstruction in infected sites since considered to be resistant to infection. Late graft occlusion is the only complication reported in literature so far. We report a case of biosynthetic graft infection which led to early detachment of the femoral anastomosis of a femoral-popliteal above-knee bypass. Read More

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November 2017
4 Reads

ChromoTrace: Computational reconstruction of 3D chromosome configurations for super-resolution microscopy.

PLoS Comput Biol 2018 03 9;14(3):e1006002. Epub 2018 Mar 9.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.

The 3D structure of chromatin plays a key role in genome function, including gene expression, DNA replication, chromosome segregation, and DNA repair. Furthermore the location of genomic loci within the nucleus, especially relative to each other and nuclear structures such as the nuclear envelope and nuclear bodies strongly correlates with aspects of function such as gene expression. Therefore, determining the 3D position of the 6 billion DNA base pairs in each of the 23 chromosomes inside the nucleus of a human cell is a central challenge of biology. Read More

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March 2018
6 Reads

Microbial flora and antibiotic resistance in odontogenic abscesses in Upstate New York.

Ear Nose Throat J 2018 Jan-Feb;97(1-2):E27-E31

Department of Otolaryngology-Head and Neck Surgery, 170 Manning Dr., Chapel Hill, NC 27599, USA.

Abscesses in the head and neck frequently have odontogenic sources. As bacterial pathogens and antibiotic resistance patterns may change over time and based on location, we describe the current common bacteria found in odontogenic abscesses, the prevalence of antibiotic resistance, and differences in each between pediatric and adult patients in Upstate New York. This is a retrospective review of patients who underwent drainage of odontogenic abscesses (n = 131) from 2002 to 2012 at an academic institution. Read More

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September 2018

Emergence of plasmid-mediated colistin resistance (mcr-1) among Enterobacteriaceae strains: Laboratory detection of resistance and measures to control its dissemination.

Med Mal Infect 2018 Jun 21;48(4):250-255. Epub 2018 Feb 21.

Commission spécialisée sécurité patient, haut conseil de la santé publique, 75014 Paris, France; Service gestion du risque infectieux, des vigilances et infectiologie, CHRU de Lille, 59000 Lille, France.

The increasing use of colistin has contributed to the emergence of resistant bacteria and to an increase in the frequency of infections caused by naturally resistant Enterobacteriaceae strains such as Proteus, Providencia, Morganella, and Serratia. In August 2016, the French High Council for Public Health (French acronym HCSP) received a request from the Ministry of Health on the advice of the French National Public Health agency (Santé publique France) with regard to measures that should be taken to tackle the emergence of plasmid-mediated colistin resistance among Enterobacteriaceae strains. French healthcare facilities were asked to take the necessary measures as soon as possible, such as updating the definition of emerging highly resistant bacteria and defining the identification methods so as to take account of the evolving epidemiology of this type of resistance. Read More

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Effect of gut bacterial isolates from on infected bee larvae.

Saudi J Biol Sci 2018 Feb 18;25(2):383-387. Epub 2017 Jul 18.

Arid Land Agriculture Department, Faculty of Agriculture & Food Sciences, King Faisal University, Al-Ahsa, Saudi Arabia.

The probiotic effects of seven newly isolated gut bacteria, from the indegenous honey bees of Saudi Arabia were investigated. bioassays were used to investigate the effects of each gut bacterium namely, (T1), (T2), (T3), (T4), (T5), (T6), and (T7) on mortality percentage of honey bee larvae infected with spores along with negative control (normal diet) and positive control (normal diet spiked with spores). Addition of gut bacteria to the normal diet significantly reduced the mortality percentage of the treated groups. Read More

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February 2018
1 Read

Plasmid-mediated quinolone resistance determinants in Enterobacteriaceae from urine clinical samples.

Acta Microbiol Immunol Hung 2018 Aug 23;65(3):255-265. Epub 2018 Feb 23.

1 Institute of Medical Microbiology, Semmelweis University , Budapest, Hungary.

Plasmid-mediated quinolone resistance (PMQR) determinants including, qnrA, qnrB, qnrC, qnrD, qnrS, aac(6')-Ib-cr, oqxAB, and qepA, were investigated in 214 Enterobacteriaceae strains from urine clinical samples. Antimicrobial susceptibility testing for ciprofloxacin, ceftriaxone, and imipenem was performed by broth microdilution method. All strains were screened for PMQR genes by PCR. Read More

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August 2018
2 Reads

Gut microbiota in the burying beetle, , provide colonization resistance against larval bacterial pathogens.

Ecol Evol 2018 02 5;8(3):1646-1654. Epub 2018 Jan 5.

Institute of Biology Leiden University Leiden The Netherlands.

Carrion beetles, are reared on decomposing carrion where larvae are exposed to high populations of carcass-derived bacteria. Larvae do not become colonized with these bacteria but instead are colonized with the gut microbiome of their parents, suggesting that bacteria in the beetle microbiome outcompete the carcass-derived species for larval colonization. Here, we test this hypothesis and quantify the fitness consequences of colonization with different bacterial symbionts. Read More

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February 2018
2 Reads

Morganella as a cause of ophthalmia neonatorum.

J AAPOS 2018 Feb 27;22(1):81-82. Epub 2017 Dec 27.

Department of Ophthalmology, University of North Carolina-Chapel Hill.

A 2 day-old-girl with a complicated birth history, including prolonged rupture of membranes and Caesarian section delivery, presented with a purulent bacterial conjunctivitis of the left eye despite standard prophylaxis. Bacterial cultures yielded 1+ Morganella morganii, a facultative anaerobe and a rare cause of ocular pathology. The patient was treated with topical tobramycin four times daily for 7 days, resulting in resolution of her conjunctivitis. Read More

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February 2018
1 Read

Fatal fibrino-hemorrhagic bronchopneumonia associated with Morganella morganii in a bottlenose dolphin: a case report.

Dis Aquat Organ 2017 Dec;127(1):41-47

Department of Pathology, Faculty of Veterinary Medicine, Kyungpook National University, Republic of Korea.

A 5 yr old, 184 kg, and 262 cm total length female bottlenose dolphin Tursiops truncatus was found dead in a display after bloody discharge from the blowhole was observed 3 h prior to death. Pathological examination revealed fibrinous bronchopneumonia with prominent areas of necrosis (sequestra) and numerous Gram-negative bacilli within alveoli and in blood vessels of the lungs and liver and between muscle fibers. The cause of death was attributed to septicemia. Read More

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December 2017
8 Reads
1 Citation
1.750 Impact Factor

Update of incidence and antimicrobial susceptibility trends of Escherichia coli and Klebsiella pneumoniae isolates from Chinese intra-abdominal infection patients.

BMC Infect Dis 2017 12 18;17(1):776. Epub 2017 Dec 18.

Division of Microbiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Wangfujing Street, Beijing, 100730, China.

Background: To evaluate in vitro susceptibilities of aerobic and facultative Gram-negative bacterial (GNB) isolates from intra-abdominal infections (IAIs) to 12 selected antimicrobials in Chinese hospitals from 2012 to 2014.

Methods: Hospital acquired (HA) and community acquired (CA) IAIs were collected from 21 centers in 16 Chinese cities. Extended spectrum beta-lactamase (ESBL) status and antimicrobial susceptibilities were determined at a central laboratory using CLSI broth microdilution and interpretive standards. Read More

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December 2017
20 Reads

Antimicrobial activity of plazomicin against Enterobacteriaceae-producing carbapenemases from 50 Brazilian medical centers.

Diagn Microbiol Infect Dis 2018 Mar 10;90(3):228-232. Epub 2017 Nov 10.

Infectious Diseases, School of Medicine, Pontificia Universidade Catolica do Parana; Hospital de Clínicas, Universidade Federal do Paraná. Electronic address:

Plazomicin is a next-generation aminoglycoside with activity against Enterobacteriaceae, including carbapenemase-producing Enterobacteriaceae (CPE). The aim of this study was to evaluate the activity of plazomicin against CPE (Klebsiella spp., Escherichia coli, Serratia spp. Read More

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March 2018
29 Reads

Assessment of the anti-snakebite properties of extracts of Aniba fragrans Ducke (Lauraceae) used in folk medicine as complementary treatment in cases of envenomation by Bothrops atrox.

J Ethnopharmacol 2018 Mar 26;213:350-358. Epub 2017 Nov 26.

Programa de Pós-graduação em Recursos Naturais da Amazônia-PPGRNA, Universidade Federal do Oeste do Pará- UFOPA, Santarém, PA, Brazil; Universidade Federal do Oeste do Pará- UFOPA, Laboratório de Bioprospecção e Biologia Experimental -LabBBEx, Santarém, PA, Brazil. Electronic address:

Ethnopharmacological Relevance: Extracts of leaves and bark of Aniba fragrans are used as tea (decoction) to treat snakebites in communities in the Brazilian Amazon. The aqueous extract of the leaves of A. fragrans has been proven to be effective against Bothrops venom, but only when pre-incubated with the venom. Read More

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March 2018
8 Reads

Incidence and Consequences of Near-Drowning-Related Pneumonia-A Descriptive Series from Martinique, French West Indies.

Int J Environ Res Public Health 2017 11 17;14(11). Epub 2017 Nov 17.

Intensive Care Unit, University Hospital of Martinique, Fort-de-France, 97261 Martinique, France.

Drowning represents one major cause of accidental death. Near-drowning patients are exposed to aspiration that may result in pneumonia with life-threatening consequences. We designed this descriptive study to investigate the frequency, nature, and consequences of post-drowning pneumonia. Read More

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November 2017
15 Reads

Diets Alter the Gut Microbiome of Crocodile Lizards.

Front Microbiol 2017 25;8:2073. Epub 2017 Oct 25.

Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou, China.

The crocodile lizard is a critically endangered reptile, and serious diseases have been found in this species in recent years, especially in captive lizards. Whether these diseases are caused by changes in the gut microbiota and the effect of captivity on disease remains to be determined. Here, we examined the relationship between the gut microbiota and diet and disease by comparing the fecal microbiota of wild lizards with those of sick and healthy lizards in captivity. Read More

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October 2017
8 Reads

Plazomicin activity against polymyxin-resistant Enterobacteriaceae, including MCR-1-producing isolates.

J Antimicrob Chemother 2017 10;72(10):2787-2791

Emerging Antibiotic Resistance, Medical and Molecular Microbiology Unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland.

Objectives: Plazomicin, a novel aminoglycoside with in vitro activity against MDR Gram-negative organisms, is under development to treat patients with serious enterobacterial infections. We evaluated the activity of plazomicin and comparators against colistin-resistant enterobacterial isolates.

Methods: Susceptibility to plazomicin and comparators was tested by broth microdilution for a collection of 95 colistin-resistant enterobacterial isolates collected from 29 hospitals in eight countries. Read More

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October 2017
16 Reads

Membrane binding of the insertion sequence of Proteus vulgaris L-amino acid deaminase stabilizes protein structure and increases catalytic activity.

Sci Rep 2017 Oct 20;7(1):13719. Epub 2017 Oct 20.

Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.

Proteus vulgaris L-amino acid deaminase (pvLAAD) belongs to a class of bacterial membrane-bound LAADs mainly express in genus Proteus, Providencia and Morganella. These LAADs employ a non-cleavable N-terminal twin-arginine translocation (Tat) peptide to transport across membrane and bind to bacterial surface. Recent studies revealed that a hydrophobic insertion sequence (INS) in these LAADs also interacts with bacterial membrane. Read More

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October 2017
6 Reads