2,565,383 results match your criteria Morbidity and mortality weekly report. Surveillance summaries Washington D.C. : 2002[Journal]


Psychological Impact of Learning CDKN2A Variant Status as a Genetic Research Result.

Public Health Genomics 2019 Apr 18;21(3-4):154-163. Epub 2019 Apr 18.

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA,

Objectives: Little is known about genetic research participants' responses to receiving individual research results (IRR) from cancer genetic research. We examined the immediate and delayed psychological impact of returning a CDKN2A variant result that is associated with increased risk of pancreatic cancer and melanoma.

Methods: One hundred and thirty-three pancreas research registry enrollees whose samples were tested in a research laboratory for the CDKN2A variant were invited by mail to learn the result by telephone and participate in a study about the disclosure process. Read More

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http://dx.doi.org/10.1159/000496556DOI Listing

House Dust Mite-Induced Allergic Lung Inflammation Is Not Exacerbated in Sickle Cell Disease Mice.

Int Arch Allergy Immunol 2019 Apr 18:1-9. Epub 2019 Apr 18.

Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, Connecticut, USA,

Aim: Asthma appears to be a common comorbid condition in children with sickle cell disease (SCD), and such individuals may be at a higher risk for increased morbidity and mortality. However, several reports have indicated that asthma severity is not particularly high in those with SCD, and airway hyperreactivity and wheeze may be independently associated with SCD. In SCD mice, exacerbated allergic airway disease (AAD) has been observed in response to the model antigen ovalbumin (OVA). Read More

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https://www.karger.com/Article/FullText/499043
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http://dx.doi.org/10.1159/000499043DOI Listing
April 2019
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Dietary inflammatory index is positively associated with serum high-sensitivity C-reactive protein in a Korean adult population.

Nutrition 2018 Nov 23;63-64:155-161. Epub 2018 Nov 23.

Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA; Connecting Health Innovations LLC, Columbia, South Carolina, USA.

Objective: To our knowledge, only a few studies have explored the relationship between the inflammatory potential of diet and serum inflammatory markers in Korean adults. The likely novel aim of this study was to examine the association between the dietary inflammatory index (DII) and serum high-sensitivity C-reactive protein (hs-CRP) in a Korean adult population.

Methods: A cross-sectional study was conducted using the data set from the Korea National Health and Nutrition Examination Survey (KNHANES) 2015. Read More

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http://dx.doi.org/10.1016/j.nut.2018.11.016DOI Listing
November 2018

Cost-Effectiveness of Negative Pressure Incision Management System in Cardiac Surgery.

J Surg Res 2019 Apr 15;240:227-235. Epub 2019 Apr 15.

Division of Thoracic & Cardiovascular Surgery, Department of Surgery, University of Virginia, Charlottesville, Virginia.

Background: Sternal wound infections (SWIs) can be a devastating long-term complication with significant morbidity and health care cost. The purpose of this analysis was to evaluate the cost-effectiveness of negative pressure incision management systems (NPIMS) in cardiac surgery.

Materials And Methods: All cardiac surgery cases at an academic hospital with risk scores available (2009-2017) were extracted from an institutional database (n = 4455). Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.046DOI Listing

Comparability of biological aging measures in the National Health and Nutrition Examination Study, 1999-2002.

Psychoneuroendocrinology 2019 Apr 4;106:171-178. Epub 2019 Apr 4.

Department of Epidemiology, Columbia University Mailman School of Public Health, United States; Robert N. Butler Columbia Aging Center, Columbia University, United States. Electronic address:

Background: Biological processes of aging are thought to be modifiable causes of many different chronic diseases. Measures of biological aging could provide sensitive endpoints for studies of risk factors hypothesized to shorten healthy lifespan and/or interventions that extend it. But uncertainty remains about how to measure biological aging and if proposed measures assess the same thing. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.03.012DOI Listing

Prediction of uncuffed tracheal tube sizes in children and infants using age/weight-based formulae: A retrospective cross-sectional study.

Int J Pediatr Otorhinolaryngol 2019 Apr 12;122:105-110. Epub 2019 Apr 12.

Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.

Introduction: The age-based formula is commonly used to predict tracheal tube (TT) sizes although its inaccuracy has been reported to reach as high as 60%. We aim to determine a practical formula using age in months and weight in kilograms to predict uncuffed tracheal tube (TT) size in children and infants.

Methods: A retrospective cross-sectional study was conducted on data obtained from a prospective study on children aged less than 9 years who came for elective surgery and received general anesthesia with oroendotracheal tube intubation at Songklanagarind Hospital between September 2008 and December 2012. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.04.011DOI Listing

Successful outcome after Pancreaticodoudenectomy in an elderly cirrhotic patient: A case report.

Int J Surg Case Rep 2019 Apr 10;58:18-20. Epub 2019 Apr 10.

Department of HPB Surgery and Liver Transplantation, Shifa International Hospital, Islamabad, Pakistan; Department of Surgery, Shifa Tameer-e-Millat University, Islamabad, Pakistan. Electronic address:

Introduction: Cirrhosis is a risk factor for poor outcomes in non-hepatic oncological resections. There are only a handful of cases demonstrating outcomes of pancreaticoduodenectomy (PD) in patients with pancreatic cancer and underlying cirrhosis. Moreover, pushing the limits of PD to elderly cirrhotic patients and demonstrating its safety remains under reported. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.034DOI Listing

Refining memory assessment of elderly people with cognitive impairment: Insights from the short-term memory binding test.

Arch Gerontol Geriatr 2019 Apr 1;83:114-120. Epub 2019 Apr 1.

Department of Basic Psychology II (Cognitive Processes), Faculty of Psychology, Complutense University of Madrid, Spain.

Alzheimer's disease (AD) affects temporary memory for bound features more remarkably than for individual features. Such selective impairments manifest from presymptomatic through dementia stages via titration procedures. A recent study suggested that without titration and with high memory load the binding selectivity may disappear in people at risk of AD such as those with Mild Cognitive Impairment (MCI). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01674943193008
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http://dx.doi.org/10.1016/j.archger.2019.03.025DOI Listing
April 2019
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Association between self-reported hearing impairment, use of a hearing aid and performance of instrumental activities of daily living.

Arch Gerontol Geriatr 2019 Apr 6;83:101-105. Epub 2019 Apr 6.

Semillero de Neurociencias y Envejecimiento, Ageing Institute, Medical School, Pontificia Universidad Javeriana, Bogotá, Colombia; Geriatric Epidemiology Research Department, Instituto Nacional De Geriatría, México City, Mexico; Geriatric Medicine Research Unit, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address:

Background And Purpose: Age-related hearing loss is a prevalent condition among the growing elderly population, which has been associated with both cognitive decline and decreased daily functioning. Decreased functioning is linked to lower performance, predominantly regarding instrumental activities of daily living (IADLs). The present study aims to explore the association between hearing loss and impairment in IADLs. Read More

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http://dx.doi.org/10.1016/j.archger.2019.04.001DOI Listing

Analysing training in gender-based violence for undergraduate nursing students in Spain: A mixed-methods study.

Nurse Educ Today 2019 Feb 12;77:71-76. Epub 2019 Feb 12.

Unit of Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umea University, SE-90187 Umea, Sweden. Electronic address:

Background: Health-care professionals, and nurses especially among them, play an essential role in the health sector's response to gender-based violence. To be able to successfully address this major public health issue they need specific training in the topic.

Objective: To analyse training on gender-based violence that nursing students receive at universities in Spain. Read More

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http://dx.doi.org/10.1016/j.nedt.2019.01.017DOI Listing
February 2019

Repeated ketamine infusions for antidepressant-resistant PTSD: Methods of a multicenter, randomized, placebo-controlled clinical trial.

Contemp Clin Trials 2019 Apr 15. Epub 2019 Apr 15.

National Center for PTSD, Clinical Neurosciences Division, US Department of Veterans Affairs, West Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

Posttraumatic stress disorder (PTSD) is a debilitating disorder with limited medication treatment options. Recent reports have described the dearth of research on new drug development as a crisis in the pharmacotherapy of PTSD. There are only two PTSD medications approved by the U. Read More

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http://dx.doi.org/10.1016/j.cct.2019.04.009DOI Listing

The historical development of pharmacopoeias and the inclusion of exotic herbal drugs with a focus on Europe and Brazil.

J Ethnopharmacol 2019 Apr 15:111891. Epub 2019 Apr 15.

Department of Biomedical Sciences, University of Cagliari, Via Ospedale 72, 09124, Cagliari, Italy. Electronic address:

Ethnopharmacological Relevance: In spite of the rich bio-cultural diversity found in the Neotropics relatively few herbal drugs native to South-America are included in the global pharmacopoeia.

Material And Methods: In the attempt to historically explain the inclusion of herbal drugs into official pharmacopoeias we consider the disparate epidemiology and cultural evolution of the New and the Old World. We then trace the development of pharmacopoeias and review forces that worked towards and against the synchronization of pharmacopoeias and highlight the role of early chemical and pharmacological studies in Europe. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111891DOI Listing

Dural ectasia in Marfan syndrome and other hereditary connective tissue disorders A 10-year follow-up study.

Spine J 2019 Apr 15. Epub 2019 Apr 15.

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway. Electronic address:

Background Context: Dural ectasia is widening of the dural sac often seen in patients with Marfan syndrome and other hereditary connective tissue disorders. Dural ectasia can cause specific symptoms and is associated with surgical complications. The knowledge on how and at which age dural ectasia develops is incomplete. Read More

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http://dx.doi.org/10.1016/j.spinee.2019.04.010DOI Listing

Narrow-band Imaging for Detection of Neoplasia at Colonoscopy: a Meta-analysis of Data From Individual Patients in Randomized Controlled Trials.

Gastroenterology 2019 Apr 15. Epub 2019 Apr 15.

Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, and Oxford NIHR Biomedical Research Centre, Oxford OX3 9DU, UK. Electronic address:

Background & Aims: Adenoma detection rate (ADR) is an important quality assurance measure for colonoscopy. Some studies suggest that narrow band imaging (NBI) may be more effective at detection of adenomas than white-light endoscopy (WLE) when bowel preparation is optimal. We conducted a meta-analysis of data from individual patients in randomized controlled trials that compared the efficacy of NBI to WLE in detection of adenomas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193570
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http://dx.doi.org/10.1053/j.gastro.2019.04.014DOI Listing
April 2019
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Leishmania infantum LeIF and its recombinant polypeptides induce the maturation of dendritic cells in vitro: an insight for dendritic cells based vaccine.

Immunol Lett 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Molecular Epidemiology and Experimental Pathology, Institut Pasteur de Tunis, Université Tunis El Manar, 13 Place Pasteur, BP 74, 1002 Tunis-Belvedère, Tunisia. Electronic address:

We previously showed that recombinant Leishmania infantum eukaryotic initiation factor (LieIF) was able to induce the secretion of cytokines IL-12, IL-10 and TNF-α by human monocytes. In this study, we explored in vitro the potential of LieIF to induce phenotypic maturation and functional differentiation of murine bone - marrow derived dendritic cells (BM-DCs). Moreover, in order to identify potential immunnomodulatory regions of LieIF, eight recombinant overlapping protein fragments covering the whole amino acid sequence ofprotein; were constructed and assessed in vitro for their ability to induce maturation of BM-DCs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01652478183041
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http://dx.doi.org/10.1016/j.imlet.2019.04.001DOI Listing
April 2019
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Economic evaluation of California prenatal participation in the special supplemental nutrition program for Women, Infants and Children (WIC) to prevent preterm birth.

Prev Med 2019 Apr 15. Epub 2019 Apr 15.

Research and Evaluation Unit, Public Health Foundation Enterprises- Special Supplemental Nutrition Program for Women, Infants and Children (PHFE WIC), 12781 Schabarum Ave., Irwindale, CA 91706.

There is growing evidence that prenatal participation in the Special Supplemental Nutrition Program for Women, Infants and Children (WIC) reduces the risk of adverse birth outcomes. With recent changes in health care, rising health care costs, and increasing rates of prematurity in the U.S. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.04.011DOI Listing

HIV co-infection in HTLV-1 carriers in Spain.

Virus Res 2019 Apr 15. Epub 2019 Apr 15.

UNIR Health Sciences School & Medical Center, Madrid, Spain. Electronic address:

Background: Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. In contrast, HTLV-1 is not endemic in Spain, despite hosting huge numbers of migrants from highly endemic regions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01681702193017
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http://dx.doi.org/10.1016/j.virusres.2019.04.004DOI Listing
April 2019
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Electronic interventions for changing knowledge, attitudes, or practices regarding contraception: a systematic review.

Contraception 2019 Apr 15. Epub 2019 Apr 15.

The Ohio State University, College of Public Health, Division of Epidemiology, Columbus, OH, 43210, USA.

Objectives: We conducted a systematic review of the effectiveness of electronic health education tools designed to improve knowledge, attitudes or practices related to contraception.

Methods: Eligible studies consisted of English-language reports published after 1990 that quantified the effects of an electronic intervention on any of the following outcomes: contraceptive knowledge, attitude toward contraceptives, contraceptive method choice, contraceptive use, or pregnancy. We conducted a systematic search of multiple electronic databases including MEDLINE, Global Health, Academic Search Complete, Cochrane Library, and Gray Literature Report. Read More

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http://dx.doi.org/10.1016/j.contraception.2019.04.004DOI Listing

Leishmaniasis in Istanbul; A new epidemiological data about refugee leishmaniasis.

Acta Trop 2019 Apr 15. Epub 2019 Apr 15.

Department of Medical Microbiology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Leishmania is an intracellular parasite, which is transmitted by the bite of infected female Phlebotominae sand flies. Turkey is a crossroad between Europe and Asia that makes it important in terms of epidemiology. In the present study, we aimed to evaluate Leishmania infection among non-autochthonous patients admitted to Health Sciences University, Dr. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X193037
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http://dx.doi.org/10.1016/j.actatropica.2019.04.008DOI Listing
April 2019
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What is the effect of a Mediterranean compared with a Fast Food meal on the exercise induced adipokine changes? A randomized cross-over clinical trial.

PLoS One 2019 18;14(4):e0215475. Epub 2019 Apr 18.

Basic and Clinical Immunology, Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal.

Background: Adipose tissue-derived adipokines are pro-inflammatory cytokines involved in metabolic-related diseases and can be influenced by diet and exercise. We aimed to compare the effect of a Mediterranean (MdM) compared with Fast Food (FFM) meal on the exercise induced adipokines changes.

Methods: In a double blinded cross over trial, 46 participants were randomly assigned to one of two standardized iso-energy pre-exercise meals: FFM or MdM-type. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215475PLOS

Variability in the validity and reliability of outcome measures identified in a systematic review to assess treatment efficacy of cognitive enhancers for Alzheimer's Dementia.

PLoS One 2019 18;14(4):e0215225. Epub 2019 Apr 18.

Institute for Health Policy, Management & Evaluation, University of Toronto, Toronto, Ontario Canada.

Introduction: Selection of optimal outcome measures is a critical step in a systematic review; inclusion of uncommon or non-validated outcome measures can impact the uptake of systematic review findings. Our goals were to identify the validity and reliability of outcome measures used in primary studies to assess cognition, function, behaviour and global status; and, to use these data to select outcomes for a systematic review (SR) on treatment efficacy of cognitive enhancers for Alzheimer's Dementia (AD).

Methods: Articles fulfilling the eligibility criteria of the SR were included in a charting exercise to catalogue outcome measures reported. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215225PLOS
April 2019
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The macroeconomic burden of noncommunicable diseases associated with air pollution in China.

PLoS One 2019 18;14(4):e0215663. Epub 2019 Apr 18.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, United States of America.

Background: While a few studies have tried to estimate the economic burden of noncommunicable diseases (NCDs) associated with air pollution, most previous studies have methodological limitations. For example, neither the cost of illness approach nor the value of a statistical life approach accounts for economic adjustment mechanisms (i.e. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215663PLOS

KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF.

PLoS One 2019 18;14(4):e0215746. Epub 2019 Apr 18.

Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America.

Understanding the regulatory mechanisms within esophageal epithelia is essential to gain insight into the pathogenesis of esophageal diseases, which are among the leading causes of morbidity and mortality throughout the world. The zinc-finger transcription factor Krüppel-like factor (KLF4) is implicated in a large number of cellular processes, such as proliferation, differentiation, and inflammation in esophageal epithelia. In murine esophageal epithelia, Klf4 overexpression causes chronic inflammation which is mediated by activation of NFκB signaling downstream of KLF4, and this esophageal inflammation produces epithelial hyperplasia and subsequent esophageal squamous cell cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215746PLOS

Role of physical performance measures for identifying functional disability among Chinese older adults: Data from the China Health and Retirement Longitudinal Study.

PLoS One 2019 18;14(4):e0215693. Epub 2019 Apr 18.

West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: Functional disability is a common health burden in older adults and follows a hierarchical pattern. Physical performance measures are useful for the objective estimation of functional disability. This study primarily aimed to compare the validity of handgrip strength and gait speed, alone and in combination, for recognizing the functional disability among Chinese older adults. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215693PLOS
April 2019
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Performance and workflow assessment of six nucleic acid extraction technologies for use in resource limited settings.

PLoS One 2019 18;14(4):e0215753. Epub 2019 Apr 18.

PATH, Seattle, Washington, United States of America.

Infectious disease nucleic acid amplification technologies (NAAT) have superior sensitivity, specificity, and rapid time to result compared to traditional microbiological methods. Recovery of concentrated, high quality pathogen nucleic acid (NA) from complex specimen matrices is required for optimal performance of several NA amplification/detection technologies such as polymerase chain reaction (PCR). Fully integrated NAAT platforms that enable rapid sample-to-result workflows with minimal user input are generally restricted to larger reference lab settings, and their complexity and cost are prohibitive to widespread implementation in resource limited settings (RLS). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215753PLOS

Effect of preconception low dose aspirin on pregnancy and live birth according to socioeconomic status: A secondary analysis of a randomized clinical trial.

PLoS One 2019 18;14(4):e0200533. Epub 2019 Apr 18.

Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States of America.

Low socioeconomic status (SES) is associated with adverse pregnancy outcomes and infertility. Low-dose aspirin (LDA) was shown to improve livebirth rates in certain subsets of women, and therefore, may impact pregnancy rates differentially by SES status. Therefore, the aim of the current study was to examine whether daily preconception-initiated LDA affects rates of pregnancy, livebirth, and pregnancy loss differently across strata of socioeconomic status (SES). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200533PLOS
April 2019
1 Read

Detection of anti-Trypanosoma cruzi antibodies by chimeric antigens in chronic Chagas disease-individuals from endemic South American countries.

PLoS One 2019 18;14(4):e0215623. Epub 2019 Apr 18.

Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.

Background: Laboratory diagnosis of chronic Chagas disease is a troubling factor due to lack of reference tests. The WHO suggests the use of two distinct commercial serological tests in parallel. The performance of commercial immunoassays might fluctuate depending on the antigenic matrices and the local strains of T. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215623PLOS

Legacy health effects among never smokers exposed to occupational secondhand smoke.

PLoS One 2019 18;14(4):e0215445. Epub 2019 Apr 18.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States of America.

Objectives: Secondhand tobacco smoke (SHTS) is a tremendous public health hazard, leading to morbidity and premature mortality worldwide, with racial and ethnic minorities and those of lower socioeconomic status disproportionately affected. Flight attendants were historically exposed to high levels of SHTS in the aircraft cabin. The health effects of active smoking are known to persist for up to a lifetime, but the legacy effects of SHTS exposure have not been well characterized. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215445PLOS

Fluorodeoxyglucose Positron Emission Tomography integrated with computed tomography in carcinoma of the cervix: Its impact on accurate staging and the predictive role of its metabolic parameters.

PLoS One 2019 18;14(4):e0215412. Epub 2019 Apr 18.

Department of Nuclear Medicine, University of Pretoria, Pretoria, South Africa.

Objectives: To determine the impact of FDG-PET/CT in the initial staging of cervical cancer among women with and without HIV and to determine the abilities of FDG-PET/CT metabolic parameters in predicting the presence of distant metastasis.

Methods: We reviewed the FDG-PET/CT images of women with FIGO stage IB2 to IVA carcinoma of the cervix. We compared the FIGO stage before and after FDG-PET/CT. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215412PLOS

Factors associated with uncontrolled asthma in adult asthmatics in Kinshasa, Democratic Republic of Congo.

PLoS One 2019 18;14(4):e0215530. Epub 2019 Apr 18.

Department of Epidemiology and Biostatistics, School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of Congo.

Background: The ultimate goal of asthma treatment is long-term control. Uncontrolled asthma is a major public health problem worldwide, but there is a lack of data on asthma control and its causes in the Democratic Republic of Congo (DRC).

Objective: To determine the socio-demographic, environmental, clinical, and biological factors and comorbidities associated with uncontrolled adult asthma in Kinshasa, DRC. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215530PLOS

Determinants of facility based-deliveries among urban slum dwellers of Kampala, Uganda.

PLoS One 2019 18;14(4):e0214995. Epub 2019 Apr 18.

Makerere University, College of Health Sciences, School of Public Health, Kampala, Uganda.

Background: Delivery in health facilities is a proxy for skilled birth attendance, which is an important intervention to reduce maternal and neonatal mortality. We investigated the determinants of facility based deliveries among women in urban slums of Kampala city, Uganda.

Methods: A cross sectional study using quantitative methods was used. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214995PLOS

A Paper-Based Car Seat Safety Educational Intervention in the Pediatric Emergency Department.

Pediatr Emerg Care 2019 Apr 16. Epub 2019 Apr 16.

Department of Emergency Medicine, Children's Hospital of Los Angeles, Los Angeles, CA.

Objective: Motor vehicle crashes are a leading source of pediatric morbidity and mortality in children younger than 13 years. Proper car seat safety device (CSD) markedly reduces mortality, but the majority of families misuse them. Emergency department (ED)-based educational interventions can improve knowledge patient regarding proper CSD use but historically have been resource intensive. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001808DOI Listing

Prophylaxis Against Early-onset Group B Streptococcus Infections in Pregnant Women Who Are Allergic to Penicillin.

Clin Obstet Gynecol 2019 Apr 16. Epub 2019 Apr 16.

Section of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma.

Group B Streptococcus (GBS) infection remains a significant cause of neonatal morbidity and mortality. Adoption of screening for maternal genital tract colonization and intrapartum antibiotic prophylaxis has significantly reduced early-onset neonatal GBS infections. For women with an allergy to penicillin, recommended agents for prophylaxis have been well-outlined, but compliance with guideline recommendations is poor. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000455DOI Listing

Pain Provocation and the Energy Cost of Walking: A Matched Comparison Study of Older Adults With and Without Chronic Low Back Pain With Radiculopathy.

J Geriatr Phys Ther 2019 Apr 15. Epub 2019 Apr 15.

Department of Physical Therapy, University of Delaware, Newark.

Background And Purpose: Chronic low back pain with radiculopathy (CLBPR) is common among older adults and can lead to walking difficulty. Energy cost of walking strongly predicts changes in walking speed, which is predictive of mortality in older adults. The purposes of this study were to examine (1) the impact of pain provocation on the energy cost of walking and (2) the relationship between pain intensity and change in energy cost of walking. Read More

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http://dx.doi.org/10.1519/JPT.0000000000000212DOI Listing

Calibration of blood pressure measurements in the Jackson Heart Study.

Blood Press Monit 2019 Apr 16. Epub 2019 Apr 16.

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.

Background: In longitudinal research studies with follow-up examinations, the devices used to measure phenotypes may change over time. When a device change occurs, the two devices should be calibrated to each other to ensure that measurements are comparable. This paper details the Jackson Heart Study (JHS) blood pressure (BP) comparability study. Read More

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http://dx.doi.org/10.1097/MBP.0000000000000379DOI Listing

Otitis Media in Childhood and Disease in Adulthood: A 40-Year Follow-Up Study.

Ear Hear 2019 Apr 16. Epub 2019 Apr 16.

Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway.

Objectives: The pathogenesis of chronic suppurative otitis media (CSOM) includes complex interactions between microbial, immunologic, and genetic factors. To our knowledge, no study has focused on the association between childhood otitis media, immune regulation, inflammatory conditions, and chronic disease in adulthood. The present study aims to assess whether CSOM in childhood predicts immune-related inflammatory disorders or cardiovascular disease in adulthood. Read More

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http://dx.doi.org/10.1097/AUD.0000000000000729DOI Listing
April 2019
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Conversion of Adjustable Gastric Banding to Stapling Bariatric Procedures: Single- or Two-stage Approach.

Ann Surg 2019 Apr 13. Epub 2019 Apr 13.

Department of Surgery, Stony Brook University, Stony Brook, NY.

Objective: The aim of this study was to compare the safety of single- versus two-stage conversion of adjustable gastric band (AGB) to gastric bypass (RYGB) or sleeve gastrectomy (SG).

Summary Background Data: AGB patients often present for conversion to RYGB or SG. The impact of single- or two-stage approach of such conversion remains unclear. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003332DOI Listing

Bariatric Surgery is Associated With Reduced Risk of Breast Cancer in Both Premenopausal and Postmenopausal Women.

Ann Surg 2019 Apr 13. Epub 2019 Apr 13.

Division of General Internal Medicine and Center for Clinical Effectiveness, University of Cincinnati, Cincinnati, OH.

MINI: We examined risk of breast cancer among 17,998 women who had bariatric surgery and 53,889 women matched on body mass index with no surgery. We found bariatric surgery was associated with a reduced risk of both premenopausal [hazard ratio (HR) = 0.72, 95% confidence interval (CI), 0. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003331DOI Listing

Utilization of Laser Therapy During Pregnancy: A Systematic Review of the Maternal and Fetal Effects Reported From 1960 to 2017.

Dermatol Surg 2019 Apr 16. Epub 2019 Apr 16.

Skin Laser & Surgery Specialists of NY and NJ, New York, New York.

Background: Due to concerns regarding maternal and fetal safety and the absence of evidence to the contrary, laser treatment during pregnancy has traditionally been limited to situations of absolute necessity.

Objective: This review seeks to examine the available evidence to determine the safety of laser therapy during pregnancy.

Methods: Medical databases were searched for relevant reports from all specialties regarding the use of lasers during pregnancy from 1960 to 2017. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001912DOI Listing

The impact of depression on adherence to organized and opportunistic breast cancer screening.

Eur J Cancer Prev 2019 Apr 16. Epub 2019 Apr 16.

Psychiatric University Hospital (UPK), University of Basel, Basel.

One in five women will experience depression over her lifetime, and one out of eight will develop breast cancer. We evaluated the effect of depression on adherence to mammography in Switzerland, where opportunistic and organized screening programs coexist. We analyzed data from 3206 women aged 50-69 who participated in the Swiss Health Survey 2012. Read More

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http://dx.doi.org/10.1097/CEJ.0000000000000520DOI Listing

Automated Ambulatory Blood Pressure Measurements and Intraoperative Hypotension in Patients Having Noncardiac Surgery with General Anesthesia: A Prospective Observational Study.

Anesthesiology 2019 Apr 15. Epub 2019 Apr 15.

From the Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine (B.S., P.C.R., C.B., J.Y.N., S.S.) the Department of Medical Biometry and Epidemiology (H.O.P.) University Medical Center Hamburg-Eppendorf, Hamburg, Germany the Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio (D.I.S.) the Department of Anesthesiology and Intensive Care Medicine, University Medical Center Rostock, Rostock, Germany (D.A.R.).

What We Already Know About This Topic: Intraoperative hypotension is associated with significant postoperative complicationsIntraoperative hypotension has been defined relative to preinduction blood pressureBlood pressure varies during the day, and the relationship between preinduction blood pressure and usual blood pressure over 24 h is incompletely describedSimilarly the relationship between low blood pressure intraoperatively and 24-h usual blood pressure is unknown WHAT THIS ARTICLE TELLS US THAT IS NEW: There is a poor correlation between preinduction blood pressure and the usual blood pressure over 24 hIn two thirds of patients, the lowest postinduction and intraoperative pressures were lower than the lowest nighttime blood pressure BACKGROUND:: Normal blood pressure varies among individuals and over the circadian cycle. Preinduction blood pressure may not be representative of a patient's normal blood pressure profile and cannot give an indication of a patient's usual range of blood pressures. This study therefore aimed to determine the relationship between ambulatory mean arterial pressure and preinduction, postinduction, and intraoperative mean arterial pressures. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002703DOI Listing

A Patient-Specific Single Sensor IoT-Based Wearable Fall Prediction and Detection System.

IEEE Trans Neural Syst Rehabil Eng 2019 Apr 16. Epub 2019 Apr 16.

Falls in! older adults are a major cause of morbidity and mortality and are a key class of preventable injuries. This paper presents a patient-specific (PS) fall prediction and detection prototype system that utilizes a single tri-axial accelerometer attached to the patient's thigh to distinguish between activities of daily living (ADL) and fall events. The proposed system consists of two modes of operation: 1) fast mode for fall predication (FMFP) predicting a fall event (300msec-700msec) before occurring, 2) slow mode for fall detection (SMFD) with a 1-sec latency for detecting a fall event. Read More

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http://dx.doi.org/10.1109/TNSRE.2019.2911602DOI Listing

Epidemiology of Exobasidium Leaf and Fruit Spot of Rabbiteye Blueberry: Pathogen Overwintering, Primary Infection, and Disease Progression on Leaves and Fruit.

Plant Dis 2019 Apr 17:PDIS09181534RE. Epub 2019 Apr 17.

Department of Plant Pathology, University of Georgia, Athens, GA.

Epidemiological field studies utilizing disease monitoring, spore trapping, and trap plants were conducted on rabbiteye blueberry () between 2014 and 2017 to shed light on the epidemiology of Exobasidium leaf and fruit spot, an emerging disease in the southeastern United States caused by the fungus . Wash plating of field-collected blueberry tissue from the late dormant season through bud expansion showed that the pathogen overwintered epiphytically on blueberry plants in the field, most likely in its yeast-like conidial stage. Agrichemical applications during the dormant season altered epiphytic populations of the pathogen, which correlated directly with leaf spot incidence later in the spring. Read More

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http://dx.doi.org/10.1094/PDIS-09-18-1534-REDOI Listing

Meeting Overview: Interferon Lambda-Disease Impact and Therapeutic Potential.

J Interferon Cytokine Res 2019 Apr 17. Epub 2019 Apr 17.

4 Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

A meeting entitled, "Interferon Lambda: Disease Impact and Translational Potential," was held on the campus of the National Institutes of Health in Bethesda, Maryland, on October 25-26, 2018. To our knowledge, this was the first meeting that focused exclusively on interferon lambda (IFN-λ). The meeting's purpose was to enhance interdisciplinary communication and promote new collaborations. Read More

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http://dx.doi.org/10.1089/jir.2019.0018DOI Listing

Alcohol Availability Across Neighborhoods in Ontario Following Alcohol Sales Deregulation, 2013-2017.

Am J Public Health 2019 Apr 18:e1-e7. Epub 2019 Apr 18.

Daniel T. Myran is with the School of Epidemiology and Public Health, University of Ottawa, Faculty of Medicine, Ottawa, ON. Jarvis T. Chen and Vaughan W. Rees are with the Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA. Benjamin Bearnot is with the Division of General Internal Medicine, Massachusetts General Hospital, Boston. Michael Ip is with the School of Epidemiology and Public Health, University of Ottawa, Faculty of Medicine. Norman Giesbrecht is with the Institute for Mental Health Policy Research, Center for Addiction and Mental Health, Toronto, ON.

To examine the association between neighborhood socioeconomic status (SES) and alcohol availability before and after deregulation in 2015 of the alcohol market in Ontario, Canada. We quantified alcohol access by number of alcohol outlets and hours of retail for all 19 964 neighborhoods in Ontario. We used mixed effects regression models to examine the associations between alcohol access and a validated SES index between 2013 and 2017. Read More

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http://dx.doi.org/10.2105/AJPH.2019.305014DOI Listing

Annexin A3 depletion overcomes resistance to oxaliplatin in colorectal cancer via the MAPK signaling pathway.

J Cell Biochem 2019 Apr 18. Epub 2019 Apr 18.

Department of Nephrology, China-Japan Union Hospital of Jilin University, Changchun, People's Republic of China.

Colorectal cancer (CRC) is a common disease with high mortality and morbidity. Annexin A3 (ANXA3) belongs to the structurally homologous family of Ca and phospholipid-binding proteins. This study aimed to investigate the effects and potential mechanisms of ANXA3 on oxaliplatin (Ox) resistance in CRC. Read More

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http://dx.doi.org/10.1002/jcb.28720DOI Listing

[Analysis of Clinical Blood Use in Emergency Blood Loss Patients].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):613-617

Department of Blood Transfusion, Chongqing Emergency Medical Center, Central Hospital Affiliated to Chongqing University ,Chongqing 400014,

Objective: To explore the blood transfusion data of emergency hemorrhage patients, so as to provide the basis for improving the quality of emergency blood transfusion and guiding clinic rational blood transfusion.

Methods: one thousand emergency blood loss patients once transfused RBC suspension were collected by Recipient Epidemiology and Donor Evaluation Study-III internationals Site range from November 2012 to November 2015. The clinical data including age, sex, clinical diagnosis etc were analyzed retrospectively. Read More

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http://dx.doi.org/10.19746/j.cnki.issn1009-2137.2019.02.049DOI Listing

Lipid Disturbances in Adolescents Treated With Second-Generation Antipsychotics: Clinical Determinants of Plasma Lipid Worsening and New-Onset Hypercholesterolemia.

J Clin Psychiatry 2019 Apr 9;80(3). Epub 2019 Apr 9.

Hôpital de Cery, 1008 Prilly-Lausanne, Switzerland.

Objective: Lipid disturbances following treatment with second-generation antipsychotics (SGAs) represent a major health concern. A previous study determined that early changes of plasma lipid levels ≥ 5% during the first month of treatment with SGAs predicts further lipid worsening and development of dyslipidemia. This current study aimed to determine the proportion of adolescents with early lipid changes ≥ 5% and who develop dyslipidemia during SGA treatment. Read More

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http://dx.doi.org/10.4088/JCP.18m12414DOI Listing
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