2,509,646 results match your criteria Morbidity and Mortality Weekly Report MMWR[Journal]


Buccal Fat Pad: Report of 24 Cases and Literature Review of 1,635 Cases of Oral Defect Reconstruction.

ORL J Otorhinolaryngol Relat Spec 2018 Dec 11;81(1):24-35. Epub 2018 Dec 11.

Maxillo-Facial Surgery Unit, Neurosensorial Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Objective: The buccal fat pad (BFP) has been progressively introduced into clinical practice for oral defect reconstruction. This study describes our experience with this technique and compares indications in the literature and outcomes.

Methods: We prospectively enrolled 24 patients presenting oral surgical defects and treated between January 2012 and January 2015 at our institution. Read More

View Article
December 2018

Individualized Hemodialysis Treatment: A Perspective on Residual Kidney Function and Precision Medicine in Nephrology.

Cardiorenal Med 2018 Dec 11;9(2):69-82. Epub 2018 Dec 11.

Harold Simmons Center of Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine School of Medicine, Orange, California,

Background: Residual kidney function (RKF) is often expected to inevitably and rapidly decline among hemodialysis patients and, hence, has been inadvertently ignored in clinical practice. The importance of RKF has been revisited in some recent studies. Given that patients with end-stage renal disease now tend to initiate maintenance hemodialysis therapy with higher RKF levels, there seem to be important opportunities for incremental hemo-dialysis by individualizing the dose and frequency according to their RKF levels. Read More

View Article
December 2018

Transition of cancer in populations in India.

Cancer Epidemiol 2018 Dec 8;58:111-120. Epub 2018 Dec 8.

Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.

Background & Objectives: An assessment of transition of cancer in India during the past 30 years, according to changes in demographic and epidemiologic risk factors was undertaken.

Materials & Methods: Cancer registry data (http://www.ncdirindia. Read More

View Article
December 2018

Why we can't determine reliably the age of a subject on the basis of his maturation degree.

J Forensic Leg Med 2018 Dec 5;61:97-101. Epub 2018 Dec 5.

Past Director of the Complex Unit of Auxology, Faculty of Medicine and Surgery, Università degli Studi di Torino, Turin, Italy. Electronic address:

Background: Maturation is the irreversible biological process leading to adult form or function. The degree of maturation can be derived from the examination of maturity indicators, i.e. Read More

View Article
December 2018
1 Read

Health utility scores of atopic dermatitis in US adults.

J Allergy Clin Immunol Pract 2018 Dec 8. Epub 2018 Dec 8.

Oregon Health & Science University, Portland, OR.

Background: The impact of atopic dermatitis (AD) on health related quality of life and health utility in the United States adult population is not well-established.

Objectives: To determine the health utilities and quality of life adjusted years (QALYs) lost in adults with vs. without AD among the US population. Read More

View Article
December 2018
1 Read

Assessment of Postoperative Outcomes in Spinal Epidural Abscess Following Surgical Decompression.

Spine J 2018 Dec 8. Epub 2018 Dec 8.

Center for Spine Health, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA; Department of Neurosurgery, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA; Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA. Electronic address:

Background Context: A spinal epidural abscess (SEA) is a serious condition that may be managed with antibiotics alone or with decompressive surgery combined with antibiotics.

Purpose: The objectives of this study were to assess the clinical outcomes of SEA after surgical management and to identify the patient-level factors that are associated with outcomes following surgical decompression and removal of SEA.

Study Design/setting: Retrospective chart review analysis. Read More

View Article
December 2018
6 Reads

A systematic review of measures estimates adherence and persistence to multiple medications.

J Clin Epidemiol 2018 Dec 8. Epub 2018 Dec 8.

University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, The Netherlands.

Objectives: We reviewed measures used to estimate adherence and persistence to multiple cardiometabolic medications from prescription data, particularly for blood pressure-lowering, lipid-lowering, and/or glucose-lowering medication, and give guidance on which measures to choose.

Study Design And Setting: A literature search of Medline, Embase, and PsycINFO databases was conducted to identify studies assessing medication adherence and/or persistence for patients using multiple cardiometabolic medications. Two reviewers performed the study selection process independently. Read More

View Article
December 2018

Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway.

Cancer Cell 2018 Dec;34(6):893-905.e8

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA; Breast Medicine Service, Department of Medicine, MSKCC, New York, NY 10065, USA; Weill-Cornell Medical College, New York, NY 10065, USA. Electronic address:

Cyclin dependent kinase 4/6 (CDK4/6) inhibitors (CDK4/6i) are effective in breast cancer; however, drug resistance is frequently encountered and poorly understood. We conducted a genomic analysis of 348 estrogen receptor-positive (ER) breast cancers treated with CDK4/6i and identified loss-of-function mutations affecting FAT1 and RB1 linked to drug resistance. FAT1 loss led to marked elevations in CDK6, the suppression of which restored sensitivity to CDK4/6i. Read More

View Article
December 2018
1 Read

Investigation of efficiency of a novel, zinc oxide loaded TEMPO-oxidized cellulose nanofiber based hemostat for topical bleeding.

Int J Biol Macromol 2018 Dec 8. Epub 2018 Dec 8.

Department of Regenerative Medicine, College of Medicine, Soonchunhyang University Cheonan-31151, Republic of Korea; Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University 366-1, Cheonan 31151, Republic of Korea. Electronic address:

Lethal bleeding due to street accidents, natural calamities, orthopedic/dental surgeries, organ transplantation and household injuries, is the leading cause of morbidity and mortality. In the current study, zinc oxide (ZnO) was incorporated in TEMPO-oxidized cellulose nanofiber (TOCN) and polyethylene glycol (PEG) polymer system for hemorrhage control by freeze drying method. SEM and XRD data showed the presence of ZnO in the porous structure. Read More

View Article
December 2018
1 Read

Measuring Value in Post-Acute Care.

Arch Phys Med Rehabil 2018 Dec 8. Epub 2018 Dec 8.

John F. Butzer Center for Research and Innovation, Mary Free Bed Rehabilitation Hospital, Grand Rapids, MI; Division of Rehabilitation, Michigan State University College of Human Medicine, Grand Rapids, MI.

The value of post-acute care is unclear. While experienced clinicians understand the appropriateness of each specific site of post-acute care, clear evidence-based guidelines are not available, and many referrals to post-acute care today are made based on bed availability rather than patient need. Measuring value (value = outcomes / cost) for the entire episode of care has been proposed as an effective method to both evaluate and enable faster innovation in care. Read More

View Article
December 2018

Micro-quantity straw as a carrier for cryopreservation of oligozoospermic semen samples: Effects of storage times and cryoprotectant.

Cryobiology 2018 Dec 8. Epub 2018 Dec 8.

Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Electronic address:

Application of an appropriate freezing carrier is crucial for improving post-thaw recovery of oligozoospermic samples. In this study, our purpose is developing a user-friendly, easy handling and close micro-quantity (MQ) straw along with different freezing media, for cryopreservation of oligozoospermic samples. Twenty oligozoospermic semen samples were collected and mixed with glycerol egg yolk citrate (GEYC) or Spermfreeze (SPF) medium. Read More

View Article
December 2018

Methicillin-resistant Staphylococcus aureus in urban Norway rat (Rattus norvegicus) populations: Epidemiology and the impacts of kill-trapping.

Zoonoses Public Health 2018 Dec 9. Epub 2018 Dec 9.

Canadian Wildlife Health Cooperative, Abbotsford, British Columbia, Canada.

Urban Norway rat (Rattus norvegicus) populations can carry the bacteria methicillin-resistant Staphylococcus aureus (MRSA). There are numerous knowledge gaps in the epidemiology of MRSA in these populations that limit understanding of its ecology in urban environments. For example, fecal shedding of MRSA, which may increase environmental contamination, has been reported in other species; however, it is unknown whether Norway rats carry the bacteria rectally. Read More

View Article
December 2018

Ciprofloxacin resistance among Campylobacter jejuni isolates obtained from shelter dogs in Texas.

Zoonoses Public Health 2018 Dec 9. Epub 2018 Dec 9.

Texas A&M University, College Station, Texas.

There are few epidemiologic studies on the shedding of Campylobacter among dogs in the United States, despite the potential public health implications. Our objectives were to estimate the prevalence of faecal Campylobacter shedding among Texas shelter dogs as detected by culture methods and to characterize the isolates by species and antimicrobial susceptibility. Using a cross-sectional study design, faecal samples were collected from 185 dogs in six animal shelters throughout Texas between May and December 2014. Read More

View Article
December 2018
1 Read

Erythrocyte sedimentation rate as an independent prognostic marker for mortality: a prospective population-based cohort study.

J Intern Med 2018 Dec 9. Epub 2018 Dec 9.

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Background: A very high erythrocyte sedimentation rate (ESR) is usually an indication of underlying pathology. Additionally, a moderately elevated ESR may also be attributable to biological ageing. Whether the ESR is a prognostic factor for mortality, regardless of age, has been scarcely investigated. Read More

View Article
December 2018

Long-Term Consequences of the Chernobyl Radioactive Fallout: An Exploration of the Aggregate Data.

Milbank Q 2018 Dec;96(4):814-857

University of Padua.

Policy Points Policymakers should invest more on researching the long-term health effects of low-ionizing radiation exposure, as we are far from reaching a consensus on a topic that is of enormous importance for public health and safety. Public policies such as those limiting the import of contaminated food from areas hit by a radioactive disaster or those regulating the resident population's access to such areas should follow a precautionary approach. Neoplasm diagnosis and medical care should be designed in order to take into account the possible role of long-term, low-dose radiation exposure. Read More

View Article
December 2018
2 Reads

Disparities in Breast Cancer Survival by Socioeconomic Status Despite Medicare and Medicaid Insurance.

Milbank Q 2018 Dec;96(4):706-754

Leonard and Madlyn Abramson Cancer Center of the University of Pennsylvania.

Policy Points Patients with low socioeconomic status (SES) experience poorer survival rates after diagnosis of breast cancer, even when enrolled in Medicare and Medicaid. Most of the difference in survival is due to more advanced cancer on presentation and the general poor health of lower SES patients, while only a very small fraction of the SES disparity is due to differences in cancer treatment. Even when comparing only low- versus not-low-SES whites (without confounding by race) the survival disparity between disparate white SES populations is very large and is associated with lower use of preventive care, despite having insurance. Read More

View Article
December 2018

Predictors of hypomanic and/or manic switch among patients who initially diagnosed unipolar major depression during acute phase antidepressants treatment.

Psychiatry Clin Neurosci 2018 Dec 9. Epub 2018 Dec 9.

Department of Health Promotion of Human Behavior and Clinical Epidemiology, Kyoto University Graduate School of Medicine / School of Public Health.

Most patients with bipolar disorder have depressive onset polarity. There is, however, very few studies investigating predictors of hypomanic and/or manic change for patients with major depression in Japan. We preliminary explored predictors of hypomanic and/or manic switch during acute phase antidepressants treatment by using the data of the SUND trial that is a multi-center randomized controlled clinical trial. Read More

View Article
December 2018

Management of common femoral artery occlusive disease: A review of endovascular treatment strategies and outcomes.

Catheter Cardiovasc Interv 2018 Dec 7. Epub 2018 Dec 7.

Department of Cardiovascular Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts.

Isolated atherosclerotic lesions of the common femoral artery (CFA) are rare but can produce significant claudication and critical limb ischemia. To date, the "gold standard" treatment for this entity has been common femoral endarterectomy (CFE) with or without patch angioplasty. However, surgery does have significant early postoperative complications, with a 15% combined mortality/morbidity. Read More

View Article
December 2018
1 Read

Rickettsioses: Cutaneous findings frequently lead to diagnosis - a review.

J Dtsch Dermatol Ges 2018 Dec;16(12):1459-1476

While epidemic typhus caused by Rickettsia prowazekii posed a significant threat in Europe before and throughout World War II due to its high mortality, the condition fortunately no longer plays a significant role. Nevertheless, rickettsioses, such as African tick bite fever, have been increasingly diagnosed in travelers returning from sub-Saharan Africa. Caused by Rickettsia africae, African tick bite fever presents with characteristic cutaneous findings such as eschar (tache noir) and a rash. Read More

View Article
December 2018

Unnötige abdominelle Eingriffe bei Patienten mit hereditärem Angioödem.

J Dtsch Dermatol Ges 2018 Dec;16(12):1443-1450

Department of Oto-Rhino-Laryngology Head and Neck Surgery, Ulm University Medical Center, Germany (Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Ulm, Deutschland).

View Article
December 2018
1 Read

Physical activity energy expenditure and cardiometabolic health in three rural Kenyan populations.

Am J Hum Biol 2018 Dec 10:e23199. Epub 2018 Dec 10.

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Objectives: Physical activity is beneficial for metabolic health but the extent to which this may differ by ethnicity is still unclear. Here, the objective was to characterize the association between physical activity energy expenditure (PAEE) and cardiometabolic risk among the Luo, Kamba, and Maasai ethnic groups of rural Kenya.

Methods: In a cross-sectional study of 1084 rural Kenyans, free-living PAEE was objectively measured using individually-calibrated heart rate and movement sensing. Read More

View Article
December 2018

Serum cotinine, vitamin D exposure levels and dental caries experience in U.S. adolescents.

Community Dent Oral Epidemiol 2018 Dec 10. Epub 2018 Dec 10.

Oral Health Services Research Core, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Richmond, Virginia.

Introduction: Epidemiologic studies of risk and protective factors for poor oral health have mostly been among children and adults, seldom focusing on adolescents. The aims of this study were to examine whether serum cotinine, a marker of tobacco exposure, and serum vitamin D are independently associated with dental caries experience among adolescents.

Methods: Cross-sectional data from 2579 adolescent participants in the 2005-2008 National Health and Nutritional Examination Survey were analysed. Read More

View Article
December 2018

The prognostic value of troponin T and N-terminal pro B-type natriuretic peptide, alone and in combination, in heart failure patients with and without diabetes.

Eur J Heart Fail 2018 Dec 10. Epub 2018 Dec 10.

BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.

Aims: We examined the prognostic importance of N-terminal pro B-type natriuretic peptide (NT-proBNP) and troponin T (TnT) in heart failure patients with and without diabetes.

Methods And Results: We measured NT-proBNP and TnT in the biomarker substudy of the Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure trial (PARADIGM-HF). Of 1907 patients, 759 (40%) had diabetes. Read More

View Article
December 2018
1 Read

How Representative are the Patients Included in the CV outcome Trials with SGLT2 Inhibitors of a General Type 2 Diabetes Population? A Large European Observational study.

Diabetes Obes Metab 2018 Dec 9. Epub 2018 Dec 9.

University Medical Center Groningen and Bethesda Diabetes Research Center, The Netherlands.

Aims: Enrollment criteria vary substantially between the cardiovascular outcome trials (CVOTs) of sodium-glucose cotransporter-2 inhibitors (SGLT-2is), impacting how representative a trial population is to the general type 2 diabetes (T2D) population. The aim was to evaluate the representativeness of four SGLT-2i CVOTs to a general T2D population.

Methods: T2D patients were included from Germany, the Netherlands, Norway, and Sweden. Read More

View Article
December 2018

Effects of chronic diseases on health-related quality of life and self-rated health among three adult age groups.

Nurs Health Sci 2018 Dec 10. Epub 2018 Dec 10.

Health Services and Outcomes Research, National Healthcare Group, Singapore.

Little is known about whether there is any difference in associations of chronic diseases with health-related quality of life and self-rated health across age groups. The purpose of the present study was to examine the associations of one specific and multiple chronic diseases with health-related quality of life and self-rated health (measured using the 5-level EQ-5D version) in three age groups: young (21-44 years), middle-aged (45-64 years), and older adults (≥65 years). Secondary data analysis of 1932 participants in the Population Health Index Survey was performed. Read More

View Article
December 2018

Allogeneic haematopoietic cell transplantation impacts on outcomes of mantle cell lymphoma with TP53 alterations.

Br J Haematol 2018 Dec 11. Epub 2018 Dec 11.

Adult BMT Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

TP53 alterations portend extremely poor prognosis in patients with mantle cell lymphoma treated with standard treatment modalities. We reviewed outcomes of 42 patients with available TP53 status who had received a reduced-intensity or non-myeloablative allogeneic haematopoietic cell transplant at our institution. We demonstrated a 2-year overall survival and progression-free survival of 78% [95% confidence interval (CI) 60-88] and 61% (95% CI 43-75), respectively. Read More

View Article
December 2018

Bibliometric analysis of scientific publications in respiratory journals from China and other top-ranking countries between 2007 and 2017.

Clin Respir J 2018 Dec 10. Epub 2018 Dec 10.

Department of Respiratory and Critical Care Medicine, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.

Introduction: Respiratory disease remains one of the leading causes of mortality and morbidity worldwide.

Objectives: In this study, we aimed to compare the quantity and quality of scientific publications in the field of respirology from the USA, the UK, Germany, Canada and China.

Methods: Articles published in 58 respiratory journals from 2007 to 2017 were screened with Science Citation Index Expanded database. Read More

View Article
December 2018

Estimating marginal proportions and intraclass correlations with clustered binary data.

Biom J 2018 Dec 11. Epub 2018 Dec 11.

Biostatistics, Department of Basic Clinical Practice, University of Barcelona, Barcelona, Spain.

A logistic regression with random effects model is commonly applied to analyze clustered binary data, and every cluster is assumed to have a different proportion of success. However, it could be of interest to obtain the proportion of success over clusters (i.e. Read More

View Article
December 2018

Management of persistent juvenile angiofibroma after endoscopic resection: Analysis of a single institution series of 74 patients.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Unit of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy.

Background: Management of persistent juvenile angiofibroma (pJA) after transnasal endoscopic resection is controversial. To better understand its behavior, optimize treatment, and minimize morbidity, we report our experience in pJA focusing on follow-up strategies and disease progression.

Methods: A retrospective review of clinical records of all JA cases treated with endoscopic surgery at the Unit of Otorhinolaryngology of the University of Brescia between January 1994 and October 2015 was performed. Read More

View Article
December 2018
1 Read

Bone Safety During the First Ten Years of Gender-Affirming Hormonal Treatment in Transwomen and Transmen.

J Bone Miner Res 2018 Dec 7. Epub 2018 Dec 7.

Department of Internal Medicine, VU University Medical Center, Amsterdam, the Netherlands.

Concerns about the effects of gender-affirming hormonal treatment (HT) on bone mineral density (BMD) in transgender people exist, particularly regarding the decrease in estrogen concentrations in transmen. Although it is known that HT is safe for BMD in the short term, long-term follow-up studies are lacking. Therefore this study aimed to investigate the change in BMD during the first 10 years of HT, to determine whether HT is safe and if assessing BMD during HT is necessary. Read More

View Article
December 2018
2 Reads

Genetic and environmental contributions to the association between mood disorder and periodontal disease: a cross-sectional study amongst female twins in the UK.

J Clin Periodontol 2018 Dec 8. Epub 2018 Dec 8.

Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.

Aim: This study aimed to investigate the factors associated with periodontal traits considering genetic and environmental background in predominantly older female twins.

Methods: This was a cross-sectional study using self-reported questionnaires for periodontal traits in TwinsUK. Age-adjusted and age-stratified multivariate analyses were conducted for all twins. Read More

View Article
December 2018

Predictors of Advance Care Planning in Older Women: The Nurses' Health Study.

J Am Geriatr Soc 2018 Dec 10. Epub 2018 Dec 10.

Department of Health Policy, Vanderbilt University School of Medicine, Nashville, Tennessee.

Background/objectives: Relatively little is known regarding predictors of advance care planning (ACP) in former nurses. We aimed to evaluate potential predictors of ACP documentation and discussion.

Design: Cross-sectional study, 2012-2014. Read More

View Article
December 2018

Management and treatment of the HCV-infected kidney transplant patient.

Semin Dial 2018 Dec 9. Epub 2018 Dec 9.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

The prevalence of hepatitis C virus infection is increased in patients with end stage kidney disease compared to the general population and is an adverse outcome determinant. Direct-acting antiviral therapy for hepatitis C virus is changing the management paradigm of infected kidney transplant candidates and recipients, with potential to reduce patient morbidity and mortality. This review describes the hepatic and nonhepatic manifestations of hepatitis C virus in kidney transplant patients as well as management and treatment strategies to optimize transplant outcomes, highlighting the importance of direct-acting antivirals in this population. Read More

View Article
December 2018

Lung function impairment in pediatric patients with sickle cell anemia from Nigeria is associated with low steady state hemoglobin.

Am J Hematol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pediatric Haematology, Evelina Children's Hospital, Guy's and St. Thomas NHS Trust, London, United Kingdom.

View Article
December 2018

The relationship between oral-health-related quality of life and general health in an elderly population: A cross-sectional study.

Gerodontology 2018 Dec 7. Epub 2018 Dec 7.

Epidemiology and Public Health, University College Cork, Cork, Ireland.

Objective: To assess the oral-health-related quality of life (OHRQoL) in a cohort of Irish older patients and explore associations with overall health status.

Background: The impact of oral health conditions on older individuals' quality of life may be influenced by patients' general health status.

Materials And Methods: This paper reports a cross-sectional study, which analysed baseline data from patients aged over 60 years. Read More

View Article
December 2018

Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock.

Cochrane Database Syst Rev 2018 Dec 10;12:CD010593. Epub 2018 Dec 10.

Intensive Care Unit, Second Affiliated Hospital Medical College, Zhejiang University, 88 Jiefang Road, Hangzhou, China, 310009.

Background: Sepsis and septic shock are potentially life-threatening complications of infection that are associated with high morbidity and mortality in adults and children. Fluid therapy is regarded as a crucial intervention during initial treatment of sepsis. Whether conservative or liberal fluid therapy can improve clinical outcomes in patients with sepsis and septic shock remains unclear. Read More

View Article
December 2018
1 Read

Prenatal diagnosis of antenatal midgut volvulus: Specific ultrasound features.

Prenat Diagn 2018 Dec 9. Epub 2018 Dec 9.

Department of Pediatric Imaging, CHU Montpellier, Montpellier, France.

Objective: To assess specific, direct, and indirect prenatal ultrasound features in cases of fetal midgut volvulus.

Methods: Retrospective case series of neonatal volvulus, based on postnatal and prenatal imaging findings that occurred from 2006-2017. Prenatal and postnatal signs including the specific "whirlpool sign" were computed. Read More

View Article
December 2018

Is the positive predictive value of high-grade cytology in predicting high-grade cervical disease falling due to HPV vaccination?

Int J Cancer 2018 Dec 10. Epub 2018 Dec 10.

VCS Population Health, VCS Foundation, Level 6, 176 Wellington Parade, East Melbourne, VIC, 3002, Australia.

A fall in the positive predictive value (PPV) of cytological predictions of high-grade squamous intraepithelial lesions (HSIL) or adenocarcinoma-in-situ (AIS) has been predicted in the post HPV vaccination era due to the decrease in underlying prevalence of cervical lesions. Data was extracted from the Victorian Cervical Screening Registry including cervical cytology tests taken between 2000 and 2016 and any subsequent histology performed within six months of the cytology. PPV was calculated for each age group (<20, 20-24, 25-29, 30-34, 35-39, 40-49, 50-59, 60-69, 70+ years) and calendar year. Read More

View Article
December 2018

Health-related behaviours of nurses and other healthcare professionals: a cross-sectional study using the scottish health survey.

J Adv Nurs 2018 Dec 10. Epub 2018 Dec 10.

School of Health & Social Care, Edinburgh Napier University, Edinburgh, EH11 4BN, Scotland, UK.

Aims: To estimate the prevalence and co-occurrence of health-related behaviours among nurses in Scotland relative to other healthcare workers and those in non-healthcare occupations.

Design: Secondary analysis of nationally representative cross-sectional data, reported following STROBE guidelines.

Methods: Five rounds (2008-2012) of the Scottish Health Survey were aggregated to estimate the prevalence and co-occurrence of health-related behaviours (smoking, alcohol consumption, physical activity, fruit/vegetable intake). Read More

View Article
December 2018

Identification of prognostic miRNA biomarkers for predicting overall survival of colon adenocarcinoma and bioinformatics analysis: A study based on The Cancer Genome Atlas database.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Department of Pharmacy, First Affiliated Hospatial of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Object: This study was conducted to identify the prognostic microRNA (miRNA) for the prediction of survival in colon adenocarcinoma (CA).

Methods: miRNA profiling of patients with CA was downloaded from The Cancer Genome Atlas (TCGA) database. After data processing, univariate Cox regression was performed to select potential prognostic miRNAs. Read More

View Article
December 2018
1 Read

Exosomes as a novel cell-free therapeutic approach in gastrointestinal diseases.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cell communication through extracellular vesicles (EVs) has been defined for many years and it is not limited only to neighboring cells, but also distant ones in organisms receive these signals. These vesicles are secreted from the variety of cells and are composed of a distinctive component such as proteins, lipids, and nucleic acids. EVs have different classified subgroups regarding their cell origin, in this context, exosomes are the most appealing particles in cell biology, especially clinical in recent years and are represented as novel therapeutic agents with numerous advantages alongside and/or over cell therapy. Read More

View Article
December 2018
1 Read

The effect of prepregnancy body mass index on the risk of gestational diabetes mellitus: A systematic review and dose-response meta-analysis.

Obes Rev 2018 Dec 10. Epub 2018 Dec 10.

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

This study was conducted to investigate the effect of the prepregnancy BMI on the risk of gestational diabetes mellitus (GDM). Five electronic databases, including PubMed, Scopus, Embase, Web of Science, and Google Scholar, were searched for literature published until 1 January 2018. The two-stage, random effect meta-analysis was performed to compare the dose-response relationship between BMI and GDM. Read More

View Article
December 2018

The effects of incretin-based therapies on beta-cell function and insulin resistance in type 2 diabetes: a systematic review and network meta-analysis combining 360 trials.

Diabetes Obes Metab 2018 Dec 9. Epub 2018 Dec 9.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China.

Aim: To evaluate the comparative effects of incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 inhibitors (DPP-4Is), on beta-cell function and insulin resistance in patients with type 2 diabetes mellitus (T2DM).

Materials And Methods: Medline, Embase, the Cochrane Library and www.clinicaltrials. Read More

View Article
December 2018

Gene-environment interactions and colorectal cancer risk: an umbrella review of systematic reviews and meta-analyses of observational studies.

Int J Cancer 2018 Dec 11. Epub 2018 Dec 11.

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, EH8 9AG, UK.

The cause of colorectal cancer (CRC) is multifactorial, involving both genetic variants and environmental risk factors. We systematically searched the MEDLINE, EMBASE, China National Knowledge Infrastructure (CNKI) and Wanfang databases from inception to December 2016, to identify systematic reviews and meta-analyses of observational studies that investigated gene-environment (G × E) interactions in CRC risk. Then, we critically evaluated the cumulative evidence for the G × E interactions using an extension of the Human Genome Epidemiology Network's Venice criteria. Read More

View Article
December 2018

Pharmacotherapy for patent ductus arteriosus closure.

Authors:
John M Ferguson

Congenit Heart Dis 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.

Even though up to 60% of premature infants less than 28 weeks gestation develop persistent patent ductus arteriosus (PDA), there remains controversy regarding if, when, and how to close the PDA. Failure to close the PDA has been associated with significant morbidity but no cause-and-effect has been proven for short-term or long-term outcomes in modern times. Surgical closure has the advantage of eliminating the PDA, but short-term complications and long-term adverse outcomes are worrisome. Read More

View Article
December 2018

Supraglottic Squamous Cell Carcinoma: A Population-Based Study of 22,675 Cases.

Laryngoscope 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology-Head and Neck Surgery, Neurological Institute of New Jersey, Newark, New Jersey, U.S.A.

Objectives/hypothesis: The authors used the Surveillance, Epidemiology, and End Results (SEER) database to analyze epidemiological features of patients presenting with supraglottic squamous cell carcinoma (SCCa) and to evaluate treatment trends and outcomes.

Methods: The SEER database was queried for patients with supraglottic SCCa from 1973 to 2013. Information on demographics; tumor size; histologic grade; American Joint Committee on Cancer (AJCC) stage; SEER local, regional, distant stage; and treatment modality were analyzed. Read More

View Article
December 2018
1 Read

Iron-fortified formula use in young children and association with socioeconomic factors in the French nationwide ELFE cohort.

Acta Paediatr 2018 Dec 7. Epub 2018 Dec 7.

Inserm, UMR1153, Centre de Recherche en Épidémiologie et Statistique Sorbonne Paris Cité (CRESS), équipe Épidémiologie Périnatale, Obstétricale et Pédiatrique (ÉPOPé) Labex GR-Ex, Paris, France.

Sacri A-S, de Lauzon-Guillain B, Dufourg M-D, Bois C, Charles M A, Chalumeau M. Iron-fortified formula use in young children and association with socioeconomic factors in the French nationwide ELFE cohort.

Aim: To study the rate of iron-fortified infant formula (IFF) use in young children in France and its association with socioeconomic factors. Read More

View Article
December 2018

Two-year prevalence of dysphagia and related outcomes in head and neck cancer survivors: An updated SEER-Medicare analysis.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: The aim of the study was to examine prevalence of dysphagia at the population level in head and neck cancer (HNC) survivors.

Methods: Surveillance, Epidemiology, and End Results-Medicare claims among 16 194 patients with HNC (2002-2011) were analyzed to estimate 2-year prevalence of dysphagia, stricture, and aspiration pneumonia, and derive treatment- and site-specific estimates.

Results: Prevalence of dysphagia, stricture, pneumonia, and aspiration pneumonia was 45. Read More

View Article
December 2018
1 Read

Genome sequence characterization of canine parvoviruses prevalent in the Sichuan province of China.

Transbound Emerg Dis 2018 Dec 11. Epub 2018 Dec 11.

China Animal Health and Epidemiology Center, Qingdao, Shandong Province, China.

Canine parvovirus 2 (CPV-2) infection is responsible for large numbers of animal deaths worldwide and is one of the most dangerous infectious diseases in young puppies. Twenty-four rectal swabs were collected from dogs with clinical signs of vomiting and hemorrhagic diarrhea and were initially verified to be infected with CPV-2 using colloidal gold test strips. From the 24 CPV-positive samples, complete genome of 5050-5054 nucleotides was sequenced with a next-generation sequencing platform. Read More

View Article
December 2018

The epidemiology of HCV infection in patients with advanced CKD/ESRD: A global perspective.

Semin Dial 2018 Dec 9. Epub 2018 Dec 9.

Division of Nephrology, Maggiore Hospital and IRCCS Foundation, Milan, Italy.

Liver disease in patients with chronic kidney disease (CKD) is most commonly due to hepatitis C virus (HCV) and contributes to increased rates of mortality. Among the pre-dialysis population, the estimated prevalence of anti-HCV positivity is based on few, limited-size studies. In hemodialysis patients however, HCV remains very prevalent despite large declines in seropositivity rates in dialysis facilities in developed countries after preventive measures were adopted in the 1990s. Read More

View Article
December 2018
1 Read
  • Page 1 of 50193