2,337 results match your criteria Moraxella Catarrhalis Infections


Polymorphism, Nasopharyngeal Bacterial Colonization, and the Development of Childhood Asthma: A Prospective Birth-Cohort Study in Finnish Children.

Genes (Basel) 2020 Jul 8;11(7). Epub 2020 Jul 8.

Institute of Biomedicine, Research Center for Infections and Immunity, University of Turku, 20520 Turku, Finland.

We aimed to explore the role of TLR4 (rs4986790) polymorphism in the nasopharyngeal (NP) bacterial colonization and its consequent impact on the development of childhood asthma. A semi-quantitative culture of NP swabs was performed on 473 children at 2 months of age and on 213 children at 13 months of age. polymorphism was analyzed for 396 children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes11070768DOI Listing

The seventh nationwide surveillance of six otorhinolaryngological infectious diseases and the antimicrobial susceptibility patterns of the isolated pathogens in Japan.

J Infect Chemother 2020 Jul 1. Epub 2020 Jul 1.

Otorhinolaryngological Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID), The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.

The Japanese Three Academic Societies Joint Antimicrobial Susceptibility Surveillance Committee conducted a nationwide surveillance on six otorhinolaryngological diseases and investigated the antimicrobial susceptibility patterns and isolation rates of the causative pathogens. The surveillance program was conducted in the otorhinolaryngological departments of 12 universities, and 36 affiliated hospitals and clinics. Patients with acute otitis media (children under six years old), chronic otitis media, acute nasal sinusitis, chronic nasal sinusitis, acute tonsillitis, and peritonsillar abscess (over 20 years old) between December 2015 and June 2017 were investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jiac.2020.05.020DOI Listing

Tetracycline resistance in Moraxella catarrhalis clinical strains isolated in Poland.

New Microbiol 2020 Jun 29;43(3). Epub 2020 Jun 29.

Medical University of Lublin, Department of Medical Microbiology, Chodźki 1, 20-093 Lublin, Poland.

Moraxella catarrhalis is considered an important, exclusively human respiratory tract pathogen which, along with Streptococcus pneumoniae and Haemophilus influenzae, is classified as one of the most frequent bacterial etiological factors causing upper respiratory tract infections. In this manuscript, we report the existence of five tetracycline-resistant M. catarrhalis strains with confirmed presence of tetracycline resistance tetB gene. Read More

View Article

Download full-text PDF

Source

The incidence of anaerobic bacteria in adult patients with chronic sinusitis: A prospective, single-centre microbiological study.

Eur J Microbiol Immunol (Bp) 2020 Jun 5. Epub 2020 Jun 5.

4 Department of Oto-Rhino-Laryngology and Head-, Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary.

Introduction: Chronic sinusitis caused by anaerobes is a particular concern clinically, because many of the complications are associated with infections caused by these organisms. The aim of this study was to evaluate the incidence of anaerobic bacteria in chronic sinusitis in adults as a part of a prospective microbiological study.

Materials And Methods: Over a one-year period, aspirations of maxillary sinus secretions and/or ethmoid cavities were derived in n = 79 adult patients with chronic sinusitis by endoscopy in a tertiary-care teaching hospital in Hungary. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1556/1886.2020.00010DOI Listing

Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of japanese society of chemotherapy, the japanese association for infectious diseases, and the japanese society for clinical microbiology in 2016: General view of the pathogens' antibacterial susceptibility.

J Infect Chemother 2020 Jun 19. Epub 2020 Jun 19.

Saiseikai Kumamoto Hospital, Kumamoto, Japan.

The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from the patients in Japan was conducted by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2016. The isolates were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections during the period between February 2016 and August 2016 by three societies. Antimicrobial susceptibility testing was conducted at the central reference laboratory according to the method recommended by Clinical Laboratory Standards Institute. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jiac.2020.05.006DOI Listing

Lascufloxacin hydrochloride to treat bacterial infection.

Drugs Today (Barc) 2020 Jun;56(6):365-376

Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.

Lascufloxacin hydrochloride (AM-1977) is a novel 8-methoxy fluoroquinolone antibacterial agent with a unique pharmacophore at the 1st and 7th positions of the quinoline nucleus developed by Kyorin Pharmaceutical Co., Ltd. (Tokyo, Japan). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1358/dot.2020.56.6.3137167DOI Listing

Airway bacterial carriage and childhood respiratory health: A population-based prospective cohort study.

Pediatr Allergy Immunol 2020 Jun 10. Epub 2020 Jun 10.

Division of Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Airway bacterial carriage might play a role in respiratory disease. We hypothesize that nasal carriage with Staphylococcus aureus or nasopharyngeal carriage with Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae predisposes individuals to adverse respiratory health.

Objective: To examine the association of early-life airway bacterial carriage with respiratory tract infections and vice versa, and of early-life airway bacterial carriage with wheezing, lung function, and asthma in later childhood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pai.13310DOI Listing

Clinical diagnostic application of metagenomic next-generation sequencing in children with severe nonresponding pneumonia.

PLoS One 2020 4;15(6):e0232610. Epub 2020 Jun 4.

Department of Respiratory Diseases, Shenzhen Children's Hospital, Shenzhen, China.

Pneumonia is one of the most important causes of morbidity and mortality in children. Identification and characterization of pathogens that cause infections are crucial for accurate treatment and accelerated recovery. However, in most cases, the causative agent cannot be identified, which is partly due to the limited spectrum of pathogens covered by current diagnostics based on nucleic acid amplification. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232610PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272011PMC

Bacterial Community Interactions During Chronic Respiratory Disease.

Front Cell Infect Microbiol 2020 14;10:213. Epub 2020 May 14.

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, United States.

Chronic respiratory diseases including chronic rhinosinusitis, otitis media, asthma, cystic fibrosis, non-CF bronchiectasis, and chronic obstructive pulmonary disease are a major public health burden. Patients suffering from chronic respiratory disease are prone to persistent, debilitating respiratory infections due to the decreased ability to clear pathogens from the respiratory tract. Such infections often develop into chronic, life-long complications that are difficult to treat with antibiotics due to the formation of recalcitrant biofilms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcimb.2020.00213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240048PMC

An up-to-date review on bio-resource therapeutics effective against bacterial species frequently associated with chronic sinusitis and tonsillitis.

Curr Med Chem 2020 May 4. Epub 2020 May 4.

Department of Plant Physiology, Institute for Biological Research "Siniša Stanković" - National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade. Serbia.

Infections of the upper respiratory tract include inflammations of the nose, sinuses (sinusitis), pharynx (tonsillitis, pharyngitis) and larynx (laryngitis) with bacteria or viruses as the main cause of these conditions. Due to their repetitive nature, chronic respiratory infections represent a global problem which is often a result of an improper treatment. If not treated adequately, these conditions may have serious consequences. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/0929867327666200505093143DOI Listing

In vitro activity of omadacycline against pathogens isolated from Mainland China during 2017-2018.

Eur J Clin Microbiol Infect Dis 2020 Aug 30;39(8):1559-1572. Epub 2020 Apr 30.

Institute of Antibiotics, Huashan Hospital, Fudan University, 12 M. Wulumuqi Rd., Shanghai, 200040, People's Republic of China.

Antibiotic resistance of bacterial pathogens isolated in China is a major concern. Omadacycline is a novel tetracycline derivative that has been approved for use in skin infections and community-acquired pneumonia. This study was conducted to determine the in vitro activity of omadacycline against a large collection of patient isolate medical centers across Mainland China. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10096-020-03877-wDOI Listing
August 2020
2.668 Impact Factor

Willd. (Rhamnaceae): it's botany, toxicity, phytochemistry and pharmacological activities.

Heliyon 2020 Apr 19;6(4):e03708. Epub 2020 Apr 19.

Central University of Technology, Faculty of Health and Environmental Sciences, Centre for Quality of Health and Living, Bloemfontein, 9300, South Africa.

is an important multi-purpose plant species that has been used in African traditional medicine for ages in the treatment of various devastating human and animal infections. The current paper is aimed at providing an overview of uses, toxicology, pharmacological properties and phytochemistry of . The information used in the current work was retrieved using various search engines, including Pubmed, Science Direct, Google Scholar, Scielo, SciFinder and Scopus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.heliyon.2020.e03708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170964PMC

A severe case with co-infection of SARS-CoV-2 and common respiratory pathogens.

Travel Med Infect Dis 2020 May - Jun;35:101672. Epub 2020 Apr 16.

Emergency Department, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tmaid.2020.101672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161507PMC

[Antimicrobial activity of dioxidine and a dioxidin-containing preparation «Nosolin-Ultra, nasal drops».]

Klin Lab Diagn 2020 ;65(4):244-250

CJSC «FIRN-M», Obolensk, Moscow region, Russia.

The study is devoted to the study of the antimicrobial activity of the antioxidant dioxidin and the complex dioxin-containing preparation Nosolin-ultra, nasal drops against planktonic and biofilm cultures of pathogens of ENT infections, the dynamics of the formation of microbial resistance to dioxidine. 11 reference strains and 9 clinical strains of microorganisms were used in the study: Streptococcus spp., Staphylococcus spp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18821/0869-2084-2020-65-4-244-250DOI Listing
January 2020

Immunologic dysfunction contributes to the otitis prone condition.

J Infect 2020 Jun 20;80(6):614-622. Epub 2020 Mar 20.

Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, NY. Electronic address:

Acute Otitis Media (AOM) is a multifactorial disease occurring mostly in young children who are immunologically naïve to AOM pathogens. This review focuses on work from Rochester NY, USA over the past 12 years among young children who had AOM infections microbiologically-confirmed by tympanocentesis, so called "stringently-defined". Among stringently-defined otitis prone children deficiencies in fundamental immune defense mechanisms have been identified that contribute to the propensity of young children to experience recurrent AOM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinf.2020.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234916PMC

[MORAXELLA OSLOENSIS BACTEREMIA WITH PNEUMONIA: FIRST REPORTED CASE IN ISRAEL].

Harefuah 2020 Mar;159(3):163-165

Galilee Medical Center, Department of Internal Medicine "D", Nahariya.

Introduction: Community acquired pneumonia (CAP), an acute infection of the pulmonary parenchyma acquired in the community, is generally treated in an outpatient setting and involves different etiological agents. In the adult community, the most common pathogen in the disease is Streptococcus pneumonia, though other multiple etiological agents (atypical) have been involved, including Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila. The genus Moraxella consists of aerobic, oxidase-positive gram-negative coccobacilli. Read More

View Article

Download full-text PDF

Source

Bacterial colonization dynamics associated with respiratory syncytial virus during early childhood.

Pediatr Pulmonol 2020 05 16;55(5):1237-1245. Epub 2020 Mar 16.

School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.

Respiratory syncytial virus (RSV) is an important cause of early life acute respiratory infections. Potentially pathogenic respiratory bacteria, including Streptococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae are frequently detected during RSV infections and associated with increased illness severity. However, the temporal dynamics of bacterial colonization associated with RSV infection remain unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24715DOI Listing

Photoinactivation of Moraxella catarrhalis Using 405-nm Blue Light: Implications for the Treatment of Otitis Media.

Photochem Photobiol 2020 05 24;96(3):611-617. Epub 2020 Apr 24.

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Moraxella catarrhalis is one of the major otopathogens of otitis media (OM) in childhood. M. catarrhalis tends to form biofilm, which contributes to the chronicity and recurrence of infections, as well as resistance to antibiotic treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/php.13241DOI Listing

Surveillance of Omadacycline Activity Tested against Clinical Isolates from the United States and Europe: Report from the SENTRY Antimicrobial Surveillance Program, 2016 to 2018.

Antimicrob Agents Chemother 2020 04 21;64(5). Epub 2020 Apr 21.

JMI Laboratories, North Liberty, Iowa, USA.

Omadacycline is a broad-spectrum aminomethylcycline approved in October 2018 by the U.S. Food and Drug Administration for treating acute bacterial skin and skin structure infections and community-acquired pneumonia as both an oral and intravenous once-daily formulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.02488-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179604PMC

Co-carriage of Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis among three different age categories of children in Hungary.

PLoS One 2020 7;15(2):e0229021. Epub 2020 Feb 7.

Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary.

Background: The nasopharynx can from time to time accommodate otherwise pathogenic bacteria. This phenomenon is called asymptomatic carriage. However, in case of decreased immunity, viral infection or any other enhancing factors, severe disease can develop. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229021PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006921PMC

Promotes Stable Polymicrobial Biofilms With the Major Otopathogens.

Front Microbiol 2019 15;10:3006. Epub 2020 Jan 15.

Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States.

Otitis media (OM) is a prevalent pediatric infection characterized by painful inflammation of the middle ear. The Gram-negative diplococcus is a commensal of the nasopharynx and one of three leading causative agents of OM. The most recent work on this multifaceted disease indicates that biofilms and polymicrobial infections play a pivotal role in recurrent and chronic OM, which are difficult to eradicate using standard antibiotic protocols. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2019.03006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974515PMC
January 2020

Discovery of Species-unique Peptide Biomarkers of Bacterial Pathogens by Tandem Mass Spectrometry-based Proteotyping.

Mol Cell Proteomics 2020 03 15;19(3):518-528. Epub 2020 Jan 15.

Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy of the University of Gothenburg, SE-40234 Gothenburg, Sweden.

Mass spectrometry (MS) and proteomics offer comprehensive characterization and identification of microorganisms and discovery of protein biomarkers that are applicable for diagnostics of infectious diseases. The use of biomarkers for diagnostics is widely applied in the clinic and the use of peptide biomarkers is increasingly being investigated for applications in the clinical laboratory. Respiratory-tract infections are a predominant cause for medical treatment, although, clinical assessments and standard clinical laboratory protocols are time-consuming and often inadequate for reliable diagnoses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.RA119.001667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050107PMC

Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence.

Drug Des Devel Ther 2019 24;13:4351-4365. Epub 2019 Dec 24.

Drug Discovery Research, Wockhardt Research Centre, Aurangabad, India.

Levonadifloxacin and its prodrug alalevonadifloxacin are novel broad-spectrum anti-MRSA agents belonging to the benzoquinolizine subclass of quinolone, formulated for intravenous and oral administration, respectively. Various in vitro and in vivo studies have established their antimicrobial spectrum against clinically significant Gram-positive, Gram-negative, atypical, and anaerobic pathogens. The potent activity of levonadifloxacin against MRSA, quinolone-resistant , and hetero-vancomycin-intermediate strains is an outcome of its well-differentiated mechanism of action involving preferential targeting to DNA gyrase. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/DDDT.S229882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935279PMC

Clinical significance of viral-bacterial codetection among young children with respiratory tract infections: Findings of RSV, influenza, adenoviral infections.

Medicine (Baltimore) 2020 Jan;99(2):e18504

Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul.

We aimed to evaluate the clinical significance of bacterial coexistence and the coinfection dynamics between bacteria and respiratory viruses among young children. We retrospectively analyzed clinical data from children aged < 5 years hospitalized with a community-acquired single respiratory viral infection of influenza, adenovirus, or RSV during 2 recent consecutive influenza seasons. Remnant respiratory specimens were used for bacterial PCR targeting Moraxella catarrhalis, Haemophilus influenzae, Streptococcus pneumoniae, and Staphylococcus aureus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000018504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959858PMC
January 2020

[Bacteriologic profile and drug resistance in children with respiratory infection from 2016 to 2018].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Dec;21(12):1182-1187

Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Objective: To study the bacteriologic profile and drug resistance of respiratory infection in children, and to provide a basis for etiological diagnosis and rational use of antimicrobial agents.

Methods: A retrospective analysis was performed for 15 047 children who attended the hospital due to respiratory infection from January 2016 to December 2018. Their sputum samples were collected, and the Phoenix-100 automatic microbial identification system was used for the identification and drug sensitivity analysis of the isolated pathogenic bacteria. Read More

View Article

Download full-text PDF

Source
December 2019

Nasopharyngeal cultures in children; when, what and why?

Int J Pediatr Otorhinolaryngol 2020 Mar 17;130:109832. Epub 2019 Dec 17.

Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, 22185, Lund, Sweden. Electronic address:

Introduction: Nasopharyngeal cultures are commonly used to determine the causative bacteria in upper airway infections. However, several bacteria can occupy the nasopharynx simultaneously and most healthy children are asymptomatic carriers of presumptive pathogens. This makes the interpretation of nasopharyngeal cultures difficult. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijporl.2019.109832DOI Listing

The Suppressive Role of Streptococcus pneumoniae Colonization in Acute Exacerbations of Childhood Bronchial Asthma.

Int Arch Allergy Immunol 2020 10;181(3):191-199. Epub 2019 Dec 10.

Department of Pediatrics, Tokai University School of Medicine, Isehara, Japan.

Introduction: Little is known about the association between bacterial infections and exacerbations of bronchial asthma.

Objective: To elucidate the effect of bacterial infections on bronchial asthma, we examined pharyngeal bacterial colonization, duration of wheezing, and serum levels of cytokines and chemokines during acute exacerbations of asthma in children.

Methods: Potential bacterial pathogens were investigated in pharyngeal samples and viruses obtained from nasal secretions of 111 children who were outpatients and/or in patients with acute exacerbations of asthma (mean/median age: 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000504541DOI Listing

The dynamics and interactions of respiratory pathogen carriage among French pilgrims during the 2018 Hajj.

Emerg Microbes Infect 2019 ;8(1):1701-1710

Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.

We conducted this study to describe the dynamics of the acquisition of respiratory pathogens, their potential interactions and risk factors for possible lower respiratory tract infection symptoms (LRTI) among French pilgrims during the 2018 Hajj. Each participant underwent four successive systematic nasopharyngeal swabs before and during their stay in Saudi Arabia. Carriage of the main respiratory pathogens was assessed by PCR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/22221751.2019.1693247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882464PMC
December 2019

The Therapeutic Effect of 1,8-Cineol on Pathogenic Bacteria Species Present in Chronic Rhinosinusitis.

Front Microbiol 2019 22;10:2325. Epub 2019 Oct 22.

Department of Otolaryngology, Head and Neck Surgery, Klinikum Bielefeld, Bielefeld, Germany.

Chronic rhinosinusitis (CRS) is marked by an inflamed mucosa of sinuses and is accompanied by a significantly reduced quality of live. Since no guidelines for the treatment of CRS are available, long lasting clinical histories with health care costs adding up to dozens of billion $ annually are caused by CRS. The progression of CRS is often induced by bacterial infections and/or a shift in microbiome as well as biofilm formation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2019.02325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821979PMC
October 2019

Leave it to Lefamulin: A Pleuromutilin Treatment Option in Community-Acquired Bacterial Pneumonia.

Drugs 2019 Nov;79(17):1867-1876

Department of Pharmacy Practice, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1718 Pine Street, Abilene, TX, 79601, USA.

Lefamulin (BC-3781) is the first systemic pleuromutilin antibiotic found to be safe and effective in the treatment of community-acquired bacterial pneumonia (CABP) in humans. This novel antibiotic was developed to combat the increasing incidence of bacterial resistance to current therapies. As the first semisynthetic pleuromutilin for systemic use in humans, lefamulin has demonstrated efficacy against the most common bacteria responsible for CABP, including strains exhibiting resistance to macrolides, fluoroquinolones, tetracyclines, vancomycin, and beta-lactams. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40265-019-01219-5DOI Listing
November 2019

In Vitro Investigation of the Antibacterial Activity of Oil on Some of the Most Commonly Isolated Bacteria in Otitis Media and Externa.

Eurasian J Med 2019 Oct;51(3):247-251

Department of Clinical Microbiology, İstanbul University-Cerrahpasa, Cerrahpasa School of Medicine, İstanbul, Turkey.

Objective: This study aimed to evaluate the antibacterial efficacy of (NS) seed oil against the most frequently isolated infectious bacteria of the middle and external ear.

Materials And Methods: The in vitro antibacterial activity of NS oil was evaluated against 34 clinical isolates of , 32 clinical isolates of , 32 clinical isolates of , and 32 clinical isolates of . , , and were also evaluated for their sensitivity to the NS oil. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5152/eurasianjmed.2019.18386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812908PMC
October 2019
1 Read

An experimental mouse model for phage therapy of bacterial pathogens causing bacteremia.

Microb Pathog 2019 Dec 3;137:103770. Epub 2019 Oct 3.

Department of Biology, College of Science, Mustansiriyah University, Box 14022, Baghdad, Iraq. Electronic address:

A minimum lethal dose on mice for five bacterial pathogens were identified with PCR of neonatal septicemia of Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa, Citrobacter freundii and Moraxella catarrhalis were studied. Bacteriophage preparations active against 10 isolates of E. coli, 10 isolates of K. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.micpath.2019.103770DOI Listing
December 2019

Genotypic differences in CC224, CC363, CC449 and CC446 of Moraxella catarrhalis isolates based on whole genome SNP, MLST and PFGE typing.

Int J Med Microbiol 2020 Jan 19;310(1):151357. Epub 2019 Sep 19.

Department of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College, 100730, Beijing, China; Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases (BZ0447), 100730, Beijing, China. Electronic address:

Understanding the evolutionary path of M. catarrhalis from macrolide-susceptible to macrolide-resistant organism, is important for hindering macrolide resistance from propagation. Multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE) and whole genome SNP typing (WGST), as useful and practical typing tools, have both advantages and disadvantages. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijmm.2019.151357DOI Listing
January 2020
3.614 Impact Factor

Examining the relationship between household air pollution and infant microbial nasal carriage in a Ghanaian cohort.

Environ Int 2019 12 10;133(Pt A):105150. Epub 2019 Sep 10.

Kintampo Health Research Centre, Kintampo, Ghana.

Background: Pneumonia, a leading cause of childhood mortality, is associated with household air pollution (HAP) exposure. Mechanisms between HAP and pneumonia are poorly understood, but studies suggest that HAP may increase the likelihood of bacterial, instead of viral, pneumonia. We assessed the relationship between HAP and infant microbial nasal carriage among 260 infants participating in the Ghana Randomized Air Pollution and Health Study (GRAPHS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envint.2019.105150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868532PMC
December 2019
5 Reads
5.559 Impact Factor

Otitis media pathogens - A life entrapped in biofilm communities.

Crit Rev Microbiol 2019 Sep - Nov;45(5-6):595-612. Epub 2019 Sep 10.

CEB - Centre of Biological Engineering, LIBRO - Laboratório de Investigação em Biofilmes Rosário Oliveira, University of Minho, Braga, Portugal.

Otitis media is a group of inflammatory diseases of the middle ear with great impact on children worldwide. The most common reported bacterial pathogens are , and . Over the last years, the role of biofilms formed by otopathogens that contribute to otitis media recurrence and chronicity has been established. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1040841X.2019.1660616DOI Listing
May 2020
2 Reads

[Screening and antibiotic resistance analysis of nasal colonized bacteria in patients with chronic rhinosinusitis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Aug;33(8):736-741

Department of Otolaryngology Head and Neck Surgery,Xijing Hospital,Fourth Military Medical University,Xi'an,710032,China.

Since bacterial infection is one of the common pathogenic factors lead to chronic rhinosinusitis (CRS), our study is designed to investigate the prevalence and antibiotic resistance of nasal colonized bacteria in patients with CRS, and to analyze the correlation between nasal colonized bacteria and pathogenesis of CRS. Nasal vestibule samples collected from 200 patients with CRS were automatically inoculated on to various bacterial culture medium, cultured by WaspLab microbiology automated system, potential pathogenic bacterial colonies grew on agar plates were then examined, identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry, and analyzed their antibiotic-resistant phenotype by antibiotic susceptibility testing. Two hundred and seventy-five bacterial strains of nasal colonization were isolated, including coagulase-negative Staphylococci, Staphylococcus aureus, Streptococcus pneumonia, Moraxella catarrhalis, Haemophilus influenza, Pseudomonas aeruginosa, and Enterobacteriaceae such as Escherichia coli and Klebsiella pneumoniae. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.13201/j.issn.1001-1781.2019.08.013DOI Listing
August 2019
2 Reads

A retrospective analysis of the pathogens in the airways of patients with primary ciliary dyskinesia.

Respir Med 2019 09 15;156:69-77. Epub 2019 Aug 15.

Institute of Medical Microbiology, University Hospital Münster, Germany. Electronic address:

Introduction: Primary ciliary dyskinesia (PCD) is a rare genetically heterogeneous disorder of motile cilia, which leads to recurrent and chronic airway infections. Detailed information about infection causing pathogens is scarce. With this study, we aimed to determine the prevalence and susceptibility of the most common respiratory pathogens in PCD patients retrospectively in a cross-sectional and the dynamics of the microbiological diversity in a longitudinal study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmed.2019.08.009DOI Listing
September 2019
1 Read

[Clinical effect of azithromycin adjuvant therapy in children with bronchiolitis: a systematic review and Meta analysis].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Aug;21(8):812-819

Department of Respiratory, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.

Objective: To systematically evaluate the clinical effect of azithromycin (AZM) adjuvant therapy in children with bronchiolitis.

Methods: Related databases were searched for randomized controlled trials (RCTs) on AZM adjuvant therapy in children with bronchiolitis published up to February 17, 2019. RevMan 5. Read More

View Article

Download full-text PDF

Source
August 2019
3 Reads

Sputum Quality Assessment Regarding Sputum Culture for Diagnosing Lower Respiratory Tract Infections in Children.

Open Access Maced J Med Sci 2019 Jun 30;7(12):1926-1930. Epub 2019 Jun 30.

Pediatric Department, Institute for Respiratory Diseases in Children, Skopje, Republic of Macedonia.

Background: The clinical relevance of specimens from the lower airways is often debatable. However, they are most commonly examined for diagnosing lower respiratory tract infections (LRTIs).

Aim: This study aimed to determine the diagnostic value of sputum quality assessment about sputum culture for diagnosing LRTIs in children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3889/oamjms.2019.551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684435PMC
June 2019
3 Reads

Ceftaroline fosamil as a potential treatment option for Staphylococcus aureus community-acquired pneumonia in adults.

Int J Antimicrob Agents 2019 Oct 9;54(4):410-422. Epub 2019 Aug 9.

Pfizer, 500 Arcola Rd, Collegeville, PA 19426, USA.

Staphylococcus aureus (S. aureus), including methicillin-resistant S. aureus (MRSA), is an important aetiological cause of community-acquired pneumonia (CAP) and associated with significant morbidity and mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijantimicag.2019.08.012DOI Listing
October 2019

The association between pneumococcal vaccination, ethnicity, and the nasopharyngeal microbiota of children in Fiji.

Microbiome 2019 07 16;7(1):106. Epub 2019 Jul 16.

Infection and Immunity, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.

Background: Streptococcus pneumoniae is a significant global pathogen that colonises the nasopharynx of healthy children. Pneumococcal conjugate vaccines, which reduce nasopharyngeal colonisation of vaccine-type S. pneumoniae, may have broader effects on the nasopharyngeal microbiota; however, data are limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40168-019-0716-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636143PMC
July 2019
4 Reads

Effects of macrolides on airway microbiome and cytokine of children with bronchiolitis: A systematic review and meta-analysis of randomized controlled trials.

Microbiol Immunol 2019 Sep 26;63(9):343-349. Epub 2019 Jul 26.

Respiratory Department, Children's Hospital of Chongqing Medical University, Chongqing, China.

Macrolides may attenuate airway inflammation of bronchiolitis with anti-inflammatory and antiviral effects. However, the potential mechanisms of action underlying the efficiency of macrolides in treating bronchiolitis are limited. Therefore, we performed a meta-analysis to assess the effects of macrolides on airway microbiome and cytokine of children with bronchiolitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1348-0421.12726DOI Listing
September 2019
3 Reads

Antimicrobial susceptibility and impact of macrolide antibiotics on Moraxella catarrhalis in the upper and lower airways of children with chronic endobronchial suppuration.

J Med Microbiol 2019 Aug 5;68(8):1140-1147. Epub 2019 Jul 5.

Child Health Division, Menzies School of Health Research, Darwin, Northern Territory 0811, Australia.

Introduction: Moraxella catarrhalis is an important but insufficiently studied respiratory pathogen.

Aim: To determine antibiotic susceptibility and impact of recent antibiotics on M. catarrhalis from children with chronic endobronchial suppuration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/jmm.0.001033DOI Listing
August 2019
2 Reads

Moraxella species: infectious microbes identified by use of time-of-flight mass spectrometry.

Jpn J Ophthalmol 2019 Jul 4;63(4):328-336. Epub 2019 Jul 4.

Department of Clinical Infectious Diseases, Aichi Medical University, Aichi, Japan.

Purpose: To report the clinical manifestations, identification, antimicrobial susceptibilities, and treatment outcomes of ocular infections caused by Moraxella species.

Study Design: Retrospective study.

Patients And Methods: The medical records of all patients treated at the Departments of Ophthalmology of the Ogaki Municipal Hospital and the Gifu University Graduate School of Medicine for ocular infections caused by Moraxella species between January 2011 and June 2017 were examined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10384-019-00669-4DOI Listing
July 2019
3 Reads

Translating Recent Microbiome Insights in Otitis Media into Probiotic Strategies.

Clin Microbiol Rev 2019 09 3;32(4). Epub 2019 Jul 3.

Environmental Ecology and Applied Microbiology Research Group, Department of Bioscience Engineering, University of Antwerp, Antwerp, Belgium

The microbiota of the upper respiratory tract (URT) protects the host from bacterial pathogenic colonization by competing for adherence to epithelial cells and by immune response regulation that includes the activation of antimicrobial and (anti-)inflammatory components. However, environmental or host factors can modify the microbiota to an unstable community that predisposes the host to infection or inflammation. One of the URT diseases most often encountered in children is otitis media (OM). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/CMR.00010-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750133PMC
September 2019
2 Reads

[Colloidal gold immunochromatographic strip for rapid detection of Haemophilus influenzae].

Sheng Wu Gong Cheng Xue Bao 2019 May;35(5):901-909

School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, Hubei, China.

To establish a novel colloidal gold immunochromatography assay (GICA) for rapid, sensitive and accurate detection of Haemophilus influenzae infection by using the outer membrane protein P6 as detection target. First, the linear antigen epitope located in the extracellular domain of the P6 protein (GenBank accession number: AGH02799) was predicted by bioinformatics analysis. The region (62-75 aa of the protein) with strong antigen specificity was chosen and synthesized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.13345/j.cjb.180428DOI Listing
May 2019
20 Reads

Distinct nasal airway bacterial microbiotas differentially relate to exacerbation in pediatric patients with asthma.

J Allergy Clin Immunol 2019 11 13;144(5):1187-1197. Epub 2019 Jun 13.

Department of Medicine, University of California, San Francisco, Calif. Electronic address:

Background: In infants, distinct nasopharyngeal bacterial microbiotas differentially associate with the incidence and severity of acute respiratory tract infection and childhood asthma development.

Objective: We hypothesized that distinct nasal airway microbiota structures also exist in children with asthma and relate to clinical outcomes.

Methods: Nasal secretion samples (n = 3122) collected after randomization during the fall season from children with asthma (6-17 years, n = 413) enrolled in a trial of omalizumab (anti-IgE) underwent 16S rRNA profiling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.05.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842413PMC
November 2019
7 Reads

Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for clinical microbiology in 2014: General view of the pathogens' antibacterial susceptibility.

J Infect Chemother 2019 Sep 10;25(9):657-668. Epub 2019 Jun 10.

Department of Infectious, Respiratory, and Digestive Medicine, University of the Ryukyus, Okinawa, Japan.

The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from the patients in Japan was conducted by Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2014. The isolates were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections during the period between January 2014 and April 2015 by three societies. Antimicrobial susceptibility testing was conducted at the central reference laboratory according to the method recommended by Clinical Laboratory Standards Institute. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jiac.2019.05.006DOI Listing
September 2019
14 Reads

and Are Important Species That Cause Ocular Infections.

Microorganisms 2019 Jun 4;7(6). Epub 2019 Jun 4.

The Charles T. Campbell Ophthalmic Microbiology Laboratory, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

is an ocular bacterial pathogen isolated in cases of keratitis, conjunctivitis, and endophthalmitis. Gram-negative brick-shaped diplobacilli from ocular specimens, and slow growth in culture, are early indications of ocular infection; however, identifying to species can be complex and inconsistent. In this study, bacteria consistent with were identified to species using: (1) DNA sequencing coupled with vancomycin susceptibility, (2) MALDI-TOF mass spectrometry, and (3) the Biolog ID system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/microorganisms7060163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616425PMC
June 2019
6 Reads