9,083 results match your criteria Mononucleosis


Extended clinical and immunological phenotype and transplant outcome in CD27 and CD70 deficiency.

Blood 2020 Jun 30. Epub 2020 Jun 30.

Ludwig Boltzmann Institute for Rare and Undagnosed Diseases, Austria.

Biallelic mutations in the genes encoding CD27 or its ligand CD70 underlie inborn errors of immunity characterized predominantly by EBV-associated immune dysregulation, such as chronic viremia, severe infectious mononucleosis, hemophagocytic lymphohistiocytosis (HLH), lymphoproliferation and malignancy. A comprehensive understanding of the natural history, immune characteristics and transplant outcomes has remained elusive. Here, in a multi-institutional global collaboration, we collected clinical information of 49 patients from 29 families (CD27 n=33, CD70 n=16), including 24 previously unreported individuals and identified a total of 16 distinct mutations in CD27, and 8 in CD70, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.2020006738DOI Listing

Septic shock caused by Fusobacterium necrophorum following sexual intercourse during recovery from infectious mononucleosis in an adolescent: a case report.

J Pediatr Adolesc Gynecol 2020 Jun 26. Epub 2020 Jun 26.

Department of Obstetrics and Gynecology, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan.

Background: Infectious mononucleosis (IM) develops following primary infection with Epstein-Barr virus. We report a case of septic shock in an adolescent from pelvic inflammatory disease caused by Fusobacterium necrophorum following sexual intercourse during recovery from IM.

Case: A 17-year-old girl with a 7-day history of fever was diagnosed with IM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpag.2020.06.018DOI Listing

Spleen: Development, anatomy and reactive lymphoid proliferations.

Semin Diagn Pathol 2020 Jun 16. Epub 2020 Jun 16.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. Electronic address:

The unique architecture of the spleen enables it to play a key role in the interactions between the circulatory, reticuloendothelial and immune systems. Response to circulating antigens in the setting of infection, autoimmune disease or other conditions may result in a range of benign lymphoid proliferations. Moreover, patients with underlying immune deficiency may also show abnormal lymphoid proliferations within the spleen. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.semdp.2020.06.003DOI Listing

Dynamically Expressed miR-BART16 Functions as a Suppressor of CAND1 in Infectious Mononucleosis Caused by Epstein-Barr Virus in Children.

Ann Clin Lab Sci 2020 May;50(3):371-377

Department of Clinical Laboratory, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Suzhou, China

Objective: MiR-BART16 is a newly discovered Epstein-Barr Virus-encoded microRNA (miRNA). We aimed to explore the role of EBV-miR-BART16 in infectious mononucleosis (IM).

Methods: Peripheral blood lymphocyte subsets were analyzed in 30 IM and 10 healthy children by flow cytometry. Read More

View Article

Download full-text PDF

Source

[Importance of machine blood count in the diagnosis of infectious mononucleosis by EBV].

Laryngorhinootologie 2020 Jun 22. Epub 2020 Jun 22.

Klinik für HNO-Heilkunde, Kopf- und Halschirurgie, Universitätsklinik Ulm, Germany.

Introduction:  EBV serology is recommended for serological diagnosis of mononucleosis. As results of an automated differential blood count is available more quickly, possible differences between an EBV primary infection and a bacterial tonsillitis were investigated.

Methods:  A retrospective evaluation of absolute and relative lymphocyte and monocyte counts of n = 140 patients > 16 years from 01/2008 to 01/2019 (mean age 21. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1190-4712DOI Listing

The Epstein-Barr virus-encoded G protein-coupled receptor BILF1 upregulates ICAM-1 through a mechanism involving the NF-қB pathway.

Biosci Biotechnol Biochem 2020 Jun 21:1-10. Epub 2020 Jun 21.

Department of Immunology, Binzhou Medical University , Yantai, China.

Although the Epstein-Barr virus (EBV) infection is usually asymptomatic, a primary encounter with the virus can cause mononucleosis. EBV infection is also strongly associated with lymphoma and epithelial cancers. The structure and infection mechanism of EBV have been well studied, but the EBV-encoded G protein-coupled receptor, BILF1, is not fully understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09168451.2020.1777525DOI Listing

Clinical characteristics of primary and reactivated Epstein-Barr virus infection in children.

Authors:
Ying Yang Feng Gao

J Med Virol 2020 Jun 19. Epub 2020 Jun 19.

Department of Neurology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China.

Objective: Epstein-Barr virus (EBV) infection occurs commonly in children and presents as primary or reactivated infection, which are difficult for clinicians to distinguish. This study investigated the clinical characteristics of the two types of infections.

Methods: Children with detectable plasma EBV-DNA were retrospectively enrolled and divided into primary and reactivated infection group by EBV-specific antibody. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jmv.26202DOI Listing
June 2020
2.347 Impact Factor

Epstein Barr virus-immortalized B lymphocytes exacerbate experimental autoimmune encephalomyelitis in xenograft mice.

J Med Virol 2020 Jun 16. Epub 2020 Jun 16.

Nebraska Center for Virology, University of Nebraska, Lincoln, NE, 68583.

Multiple sclerosis (MS) is the most common autoimmune disorder affecting the central nervous system. Epstein-Barr virus (EBV) is a causative agent for infectious mononucleosis (IM) that is associated with MS pathogenesis. However, the exact mechanism by which EBV, specifically in IM, increases the risk for MS remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jmv.26188DOI Listing

Epidemiology of Epstein-Barr virus infection and infectious mononucleosis in the United Kingdom.

BMC Public Health 2020 Jun 12;20(1):912. Epub 2020 Jun 12.

Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University London, London, UK.

Background: Epstein-Barr Virus (EBV) is a ubiquitous gamma-herpesvirus with which ~ 95% of the healthy population is infected. EBV infection has been implicated in a range of haematological malignancies and autoimmune diseases. Delayed primary EBV infection increases the risk of subsequent complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12889-020-09049-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291753PMC

Infectious Mononucleosis and Upper Airway Obstruction: Intracapsular Tonsillectomy and Adenoidectomy With Microdebrider for Prompt Relief.

Ear Nose Throat J 2020 Jun 8:145561320930046. Epub 2020 Jun 8.

Division of Otolaryngology-Head & Neck Surgery, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0145561320930046DOI Listing

[Viral hepatitis B, C and infectious mononucleosis: epidemiological similarities and differences.]

Vopr Virusol 2020;65(1):27-34

National Research Center of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya, Moscow, 123098, Russia.

Introduction: The presence of etiologically unencrypted diagnoses in the structure of viral hepatitis determines the relevance of searching for other pathogens involved in liver pathology formation. The role of Epstein-Barr virus in the development of hepatitis was described in the scientific literature, but official statistics do not allow to assess its contribution to liver damage along with hepatitis B and C viruses. The purpose - to identify common and distinctive epidemiological features of viral hepatitis B (HB), C (HC) and infectious mononucleosis (IM). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.36233/0507-4088-2020-65-1-27-34DOI Listing
January 2020

A novel vaccine candidate based on chimeric virus-like particle displaying multiple conserved epitope peptides induced neutralizing antibodies against EBV infection.

Theranostics 2020 27;10(13):5704-5718. Epub 2020 Apr 27.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Department of Experimental Research, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, PR China.

: Epstein-Barr virus (EBV) is the causative pathogen for infectious mononucleosis and many kinds of malignancies including several lymphomas such as Hodgkin's lymphoma, Burkitt's lymphoma and NK/T cell lymphoma as well as carcinomas such as nasopharyngeal carcinoma (NPC) and EBV-associated gastric carcinoma (EBV-GC). However, to date no available prophylactic vaccine was launched to the market for clinical use. : To develop a novel vaccine candidate to prevent EBV infection and diseases, we designed chimeric virus-like particles (VLPs) based on the hepatitis B core antigen (HBc149). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/thno.42494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255000PMC

Dynamic Distribution and Clinical Value of Peripheral Lymphocyte Subsets in Children with Infectious Mononucleosis.

Indian J Pediatr 2020 May 30. Epub 2020 May 30.

Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Street, OuHai District, Wenzhou, 325000, People's Republic of China.

Objective: To study the dynamic change of peripheral lymphocyte subsets and its clinical value in children with infectious mononucleosis (IM).

Methods: Thirty-six pediatric patients with IM, 19 children with IM-like symptoms but lacking the serological pattern compatible with EB virus infection, and 33 healthy children were enrolled. The changes of peripheral lymphocyte subsets were detected by flow cytometry on admission and on the fifth day of antiviral treatment, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12098-020-03319-7DOI Listing

Sulfasalazine-induced mononucleosis-like-illness and haemolysis.

Scand J Rheumatol 2020 May 29:1-2. Epub 2020 May 29.

3rd Medical Department (Nephrology and Rheumatology), Sana Klinikum Offenbach , Offenbach, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/03009742.2020.1747533DOI Listing

Molecular characterization of Epstein-Barr virus variants detected in the oral cavity of adolescents in Cali, Colombia

Biomedica 2020 05 1;40(Supl. 1):76-88. Epub 2020 May 1.

Departamento de Biología, Facultad de Ciencias Naturales y Exactas, Universidad del Valle, Cali, Colombia.

Introduction: The Epstein-Barr virus (EBV) is an ubiquitous and oncogenic virus associated with the development of diseases such as infectious mononucleosis, Burkitt’s lymphoma, nasopharyngeal carcinoma, and other neoplasms. Currently, two types are recognized: EBV-1 and EBV-2, which have genetic differences with their EBNA nuclear antigens. Likewise, due to the high degree of heterogeneity and variability found in the LMP1 protein of the virus, variants associated with pathogenesis or specific geographic regions have been described. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7705/biomedica.4917DOI Listing

Harm as a Necessary Component of the Concept of Medical Disorder: Reply to Muckler and Taylor.

J Med Philos 2020 May;45(3):350-370

Katholieke Universiteit Leuven, Leuven, BE, and New York University, New York, USA.

Wakefield's harmful dysfunction analysis asserts that the concept of medical disorder includes a naturalistic component of dysfunction (failure of biologically designed functioning) and a value (harm) component, both of which are required for disorder attributions. Muckler and Taylor, defending a purely naturalist, value-free understanding of disorder, argue that harm is not necessary for disorder. They provide three examples of dysfunctions that, they claim, are considered disorders but are entirely harmless: mild mononucleosis, cowpox that prevents smallpox, and minor perceptual deficits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jmp/jhaa008DOI Listing

A 45-year-old Female with an Atypical Presentation of Pharyngitis.

Clin Pract Cases Emerg Med 2020 May 27;4(2):234-240. Epub 2020 Apr 27.

Reynold's Memorial Hospital, Department of Emergency Medicine, Glen Dale, West Virginia.

Introduction: Emergency physicians are trained to treat a variety of ailments in the emergency department (ED), some of which are emergent, while others are not. A common complaint seen in the ED is a sore throat. While most sore throats are easily diagnosed and treated, less common causes are often not considered in the differential diagnoses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5811/cpcem.2020.2.46974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219994PMC

Intrathecal immunoreactivity in people with or without previous infectious mononucleosis.

Acta Neurol Scand 2020 May 16. Epub 2020 May 16.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Objectives: The risk of developing multiple sclerosis (MS) increases (OR: 3.1) after infectious mononucleosis (IM). However, the nature of this link is obscure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ane.13280DOI Listing

Tracking immunodynamics by identification of S-G/M-phase T cells in human peripheral blood.

J Autoimmun 2020 May 12:102466. Epub 2020 May 12.

Immunosurveillance Laboratory, The Francis Crick Institute, London, UK; Peter Gorer Department of Immunobiology, King's College London, London, UK; Institute of Molecular Biology and Pathology, National Research Council of Italy (CNR), Rome, Italy. Electronic address:

The ready availability of human blood makes it the first choice for immuno-monitoring. However, this has been largely confined to static metrics, particularly resting T cell phenotypes. Conversely, dynamic assessments have mostly relied on cell stimulation in vitro which is subject to multiple variables. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2020.102466DOI Listing

Woman with sore throat, fever and abdominal pain.

Eur J Intern Med 2020 Jun 11;76:89-90. Epub 2020 May 11.

Emergency Department, Strasbourg University Hospital, Hautepierre Hospital, 1 Avenue Molière, 67200 Strasbourg, France; INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), Fédération de Médecine Translationnelle (FMTS), University of Strasbourg, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejim.2020.04.038DOI Listing

An Atypical Presentation of Epstein-Barr Virus Associated Infectious Mononucleosis Mistaken for Pyelonephritis.

Cureus 2020 Apr 7;12(4):e7583. Epub 2020 Apr 7.

Nephrology, Raymond G. Murphy Veterans Affairs Medical Center, Albuquerque, USA.

Infectious mononucleosis, a syndrome characterized by the triad of pharyngitis, fever, and lymphadenopathy, is caused in the majority of cases by Epstein-Barr virus and usually presents in adolescents and young adults. The disease is for the most part self-limited with full recovery; however, life-threatening complications can occur. Manifestations of Epstein-Barr virus associated infectious mononucleosis can be variable and at times atypical, leading to a delay in diagnosis and consequently unnecessary tests and treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212761PMC

Epstein-Barr Virus and Cytomegalovirus Infections of the Liver.

Gastroenterol Clin North Am 2020 Jun;49(2):331-346

Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania, 2 Dulles, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address:

Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infections are common and are associated with a variety of liver manifestations. EBV and CMV infections, in immunocompetent hosts, commonly manifest as acute hepatitis, with severity varying from asymptomatic, self-limited icteric hepatitis to acute liver failure. Atypical manifestations, such as cholestasis, chronic hepatitis, precipitation of acute-on-chronic liver failure, and autoimmune hepatitis, are reported with EBV infection, whereas cholestasis, portal vein thrombosis, and Budd-Chiari syndrome are reported with CMV infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gtc.2020.01.008DOI Listing

Neutropenia induced by large granular lymphocytes secondary to adalimumab and reactivated mononucleosis: case report and literature review.

Gastroenterol Hepatol 2020 May 5. Epub 2020 May 5.

Servicio de Aparato Digestivo, Complejo Hospitalario de Navarra, Pamplona.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gastrohep.2020.02.012DOI Listing

Epstein-Barr Virus Infection-associated Hemophagocytic Lymphohistiocytosis.

Cureus 2020 Apr 6;12(4):e7563. Epub 2020 Apr 6.

Hematology, Dartmouth-Hitchcock Norris Cotton Cancer Center, Lebanon, USA.

Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening syndrome characterized by uncontrolled immune activation. There is an aberrant activation of lym-phocytes and macrophages that results in hypercytokinemia. We aim to describe a case of secondary HLH due to primary Epstein-Barr virus (EBV) infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202582PMC

Vaccination against the Epstein-Barr virus.

Cell Mol Life Sci 2020 May 4. Epub 2020 May 4.

Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland.

Epstein-Barr virus (EBV) was the first human tumor virus being discovered and remains to date the only human pathogen that can transform cells in vitro. 55 years of EBV research have now brought us to the brink of an EBV vaccine. For this purpose, recombinant viral vectors and their heterologous prime-boost vaccinations, EBV-derived virus-like particles and viral envelope glycoprotein formulations are explored and are discussed in this review. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-020-03538-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223886PMC

Corticosteroids as standalone or add-on treatment for sore throat.

Cochrane Database Syst Rev 2020 05 1;5:CD008268. Epub 2020 May 1.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Background: Sore throat is a common condition associated with a high rate of antibiotic prescriptions, despite limited evidence for the effectiveness of antibiotics. Corticosteroids may improve symptoms of sore throat by reducing inflammation of the upper respiratory tract. This review is an update to our review published in 2012. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/14651858.CD008268.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193118PMC

Lymphoma Mimicking Chronic Active Epstein-Barr Virus: A Case Report.

Head Neck Pathol 2020 Apr 29. Epub 2020 Apr 29.

Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, Box 1189, One Gustave L Levy Place, NY, 10029, New York, USA.

Epstein-Barr virus (EBV) is the main cause of infectious mononucleosis (IM), a self-limiting infection among immunocompetent patients. EBV is also implicated in the development of several malignancies. We describe a case of a previously healthy 34-year-old man who presented with non-tender, enlarging, right cervical lymphadenopathy for over a year that was associated with significant weight loss, fevers, and night sweats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12105-020-01154-yDOI Listing

Nasopharyngeal airway for upper airway obstruction in infectious mononucleosis.

Pediatr Int 2020 May 28;62(5):642-643. Epub 2020 Apr 28.

Children's Medical Center, Kitakyushu City Yahata Hospital, Kitakyushu City, Fukuoka, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ped.14143DOI Listing

Dermatological manifestations of Epstein-Barr virus systemic infection: a case report and literature review.

Int J Dermatol 2020 Apr 28. Epub 2020 Apr 28.

Dermatology Clinic, Ospedale Policlinico San Martino, Genoa, Italy.

Epstein-Barr virus (EBV) is a human herpesvirus spread in childhood by contact with saliva. In all populations, the great majority of people are infected by middle age. EBV can cause asymptomatic infection, nonspecific symptoms or, especially in adolescents and young adults, the infectious mononucleosis (IM), characterized by pharyngitis, lymphadenopathy, fatigue, and fever. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijd.14887DOI Listing

Limited Utility of Serology and Heterophile Test in the Early Diagnosis of Epstein-Barr Virus Mononucleosis in a Child after Renal Transplantation.

Medicines (Basel) 2020 Apr 22;7(4). Epub 2020 Apr 22.

Division of Pediatric Nephrology, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.

Epstein-Barr virus (EBV) infection is associated with significant morbidity and mortality in renal transplant (RT) recipients. The spectrum of illness ranges from infectious mononucleosis (IM) to post-transplant lymphoproliferative disorder (PTLD). In association with clinical signs and symptoms, virus-specific serology and heterophile antibody tests are widely used in confirming the diagnosis of IM in the general population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/medicines7040021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235840PMC

[Relationship between Single Nucleotide Polymorphisms of IL2RA, IL-10 Gene and Epstein-Barr Virus Associated Hemophagocytic Lymphohistiocytosisin in children].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Apr;28(2):646-651

Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510000, Guangdong Province, China,E-mail: com.

Objective: To investigate the correlation of single nucleotide polymorphisms (SNPs) of IL2RA and IL-10 gene with the pathogenesis of Epstein Barr Virus associated hemophagocytic lymphohistiocytosis (EBV-HLH) in children and the effect of correlated SNPs on the prognosis of children with EBV-HLH.

Methods: For EBV-HLH group (51 cases), EBV-associated infectious mononucleosis (EBV-IM) group (48 cases) and EBV-positive healthy children group (52 cases), the genotypes at rs2104286, rs12722489, rs11594656 of IL2RA gene and rs1800896, rs1800871 and rs1800872 of IL-10 gene were detected with the SNaPshot technique. The distribution differences of genotype frequency and allele frequency of each SNP in each group were analyzed, and the correlated SNPs were taken as the research object for survival analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2020.02.048DOI Listing

COVID-19 diagnosis does not rule out other concomitant diseases.

Eur J Clin Invest 2020 Jun 5;50(6):e13241. Epub 2020 May 5.

Section of Infectious Diseases, Department of Safety and Bioethics, Catholic University of the Sacred Heart, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/eci.13241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235488PMC

Childhood infections, vaccinations, and tonsillectomy and risk of first clinical diagnosis of CNS demyelination in the Ausimmune Study.

Mult Scler Relat Disord 2020 Jul 18;42:102062. Epub 2020 Mar 18.

National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australian Capital Territory, Australia; Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Australia. Electronic address:

Background: The association between childhood vaccinations and infections and risk of multiple sclerosis is unclear; few studies have considered age at vaccination/infection.

Objective: To explore age-related associations between childhood vaccinations, infection and tonsillectomy and risk of a first clinical diagnosis of CNS demyelination.

Methods: Data on case (n = 275, 76. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msard.2020.102062DOI Listing

Lipschütz's acute vulvar ulcer: a systematic review.

Eur J Pediatr 2020 Apr 15. Epub 2020 Apr 15.

Pediatric Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona, Switzerland.

In previously healthy subjects, vulvar ulcers are mostly caused by sexually transmitted microorganisms. Lipschütz's acute vulvar ulceration, first reported in 1912, is a non-sexually acquired condition characterized by sudden onset of a few genital ulcers. We systematically review presentation, underlying causes, and disease duration of Lipschütz's ulceration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-020-03647-yDOI Listing

Infectious mononucleosis complicated by peritonsillar abscess and postural orthostatic tachycardia syndrome: A case report.

Authors:
Kaspar L Yaxley

SAGE Open Med Case Rep 2020 2;8:2050313X20915413. Epub 2020 Apr 2.

Royal Perth Hospital, Perth, WA, Australia.

An unusual case of infectious mononucleosis complicated by both peritonsillar abscess and postural orthostatic tachycardia syndrome is reported. The patient was diagnosed with Epstein-Barr virus infection early in the disease course by her primary care doctor. She subsequently developed a peritonsillar abscess requiring hospitalisation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050313X20915413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139175PMC

The Serum MAC-2-binding Protein Glycosylation Isomer Dynamics in Acute Liver Injury.

Intern Med 2020 Apr 9. Epub 2020 Apr 9.

Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center, Kanazawa, Japan.

Objective We aimed to examine the dynamics of serum Wisteria floribunda agglutinin-positive human MAC-2-binding protein glycosylation isomer (M2BPGi) in patients with acute liver injury. Methods Serum M2BPGi levels at the time of the diagnosis (n=77) and normalization of the serum alanine aminotransferase (ALT) level (n=26) were examined retrospectively. The difference in the serum M2BPGi level according to the etiology, and the correlations with other laboratory parameters were evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2169/internalmedicine.3867-19DOI Listing

A Pentavalent Epstein-Barr Virus-Like Particle Vaccine Elicits High Titers of Neutralizing Antibodies against Epstein-Barr Virus Infection in Immunized Rabbits.

Vaccines (Basel) 2020 Apr 6;8(2). Epub 2020 Apr 6.

Department of Immuno-Oncology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.

Primary infection with Epstein-Barr virus (EBV) is associated with acute infectious mononucleosis, whereas persistent infection is associated with chronic diseases such as autoimmune diseases and various types of cancer. Indeed, approximately 2% of all new cancer cases occurring annually worldwide are EBV-associated. Currently, there is no licensed EBV prophylactic vaccine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/vaccines8020169DOI Listing

Risk factors for Epstein Barr virus-associated cancers: a systematic review, critical appraisal, and mapping of the epidemiological evidence.

J Glob Health 2020 Jun;10(1):010405

Institute for Global Health, University College London, London, UK.

Background: Epstein Barr Virus (EBV) infects 90%-95% of all adults globally and causes ~ 1% of all cancers. Differing proportions of Burkitt's lymphoma (BL), gastric carcinoma (GC), Hodgkin's lymphoma (HL) and nasopharyngeal carcinoma (NPC) are associated with EBV. We sought to systematically review the global epidemiological evidence for risk factors that (in addition to EBV) contribute to the development of the EBV-associated forms of these cancers, assess the quality of the evidence, and compare and contrast the cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7189/jogh.10.010405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125417PMC

Predictors of Epstein-Barr virus serostatus and implications for vaccine policy: A systematic review of the literature.

J Glob Health 2020 Jun;10(1):010404

Centre for Molecular Epidemiology and Translational Research, Institute for Global Health, University College London, London, UK.

Background: Epstein-Barr virus (EBV) is an important human pathogen; it infects >90% people globally and is linked to infectious mononucleosis and several types of cancer. Vaccines against EBV are in development. In this study we present the first systematic review of the literature on risk factors for EBV infection, and discuss how they differ between settings, in order to improve our understanding of EBV epidemiology and aid the design of effective vaccination strategies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7189/jogh.10.010404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125428PMC

Environmental factors and risk of multiple sclerosis: Findings from meta-analyses and Mendelian randomization studies.

Mult Scler 2020 Apr 6;26(4):397-404. Epub 2019 Sep 6.

Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece/Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.

Multiple sclerosis (MS) is a chronic demyelinating disease that is associated with permanent disability and low quality of life. Development of MS is attributed to a combination of genetic and environmental factors. Genome-wide association studies revealed more than 200 variants that are associated with risk of MS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1352458519872664DOI Listing

Correction to: Infectious mononucleosis, immune genotypes, and non-Hodgkin lymphoma (NHL): an InterLymph Consortium study.

Cancer Causes Control 2020 Jun;31(6):607

Department of Preventive Medicine, Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Unfortunately, the word "Group" is missed in the article title of the original publication. It has been corrected by this erratum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10552-020-01297-xDOI Listing

Identifying Psychological Difficulties in College Athletes.

J Allergy Clin Immunol Pract 2020 Mar 21. Epub 2020 Mar 21.

Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill. Electronic address:

Psychological conditions occur frequently in college students. One contributing factor is the onset of most mental health disorders occurring in late adolescence and early adulthood, as well as the identity formation and individuation that is typical of this developmental stage. Precollege trauma (emotional, physical, sexual, and witness to violence) and lower socioeconomic status can set the stage for psychological difficulties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2020.03.006DOI Listing

Altered ratio of circulating follicular regulatory T cells and follicular helper T cells during primary EBV infection.

Clin Exp Med 2020 Mar 23. Epub 2020 Mar 23.

Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, 158 Shangtang Road, Hangzhou, 310014, China.

Follicular help T cells (Tfh) play an important role in the activation and differentiation of B cells, while follicular regulatory T cells (Tfr) control Tfh and resulting humoral immune responses. Accumulating evidence has demonstrated that the dysregulation of Tfr contributed to the pathogenesis of infectious diseases. However, the role of Tfr in Epstein-Barr virus (EBV) infection remains lacking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10238-020-00621-8DOI Listing

Systematic review and meta-analysis of the association between Epstein-Barr virus, multiple sclerosis and other risk factors.

Mult Scler 2020 Mar 23:1352458520907901. Epub 2020 Mar 23.

Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK/Royal London Hospital, London, UK.

Background: Epstein-Barr virus (EBV) infection is thought to play a central role in the development of multiple sclerosis (MS). If causal, it represents a target for interventions to reduce MS risk.

Objective: To examine the evidence for interaction between EBV and other risk factors, and explore mechanisms via which EBV infection may influence MS risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1352458520907901DOI Listing

Recent Advances in Diagnostic Approaches for Epstein-Barr Virus.

Pathogens 2020 Mar 18;9(3). Epub 2020 Mar 18.

Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan 16150, Malaysia.

Epstein-Barr virus (EBV) is the causative agent of many diseases including infectious mononucleosis (IM), and it is associated with different subtypes of lymphoma, sarcoma and carcinoma such as Hodgkin's lymphoma, non-Hodgkin's lymphoma, nasopharyngeal carcinoma, and gastric carcinoma. With the advent of improved laboratory tests for EBV, a timelier and accurate diagnosis could be made to aid better prognosis and effective treatment. For histopathological lesions, the in situ hybridization (ISH) of EBV-encoded RNA (EBER) in biopsy tissues remains the gold standard for detecting EBV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/pathogens9030226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157745PMC

Fine needle cytology features of an atypical presentation of infectious mononucleosis.

J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S139-S142. Epub 2020 Feb 28.

Department of Oral Pathology and Diagnosis, Faculty of Dentistry, Universidad de Valparaíso, Valparaíso, Chile.

Infectious mononucleosis (IM) is a very common disease, and although in most instances, the patient develops an asymptomatic infection, other patients progress into an array of signs and symptoms that tend to be characteristic of the pathological process, guiding the clinician into choosing the right laboratory examinations under the suspicion of this illness. The most common symptoms are pharyngitis, lymphadenopathies and pyrexia, and the probabilities to develop this mononucleosis triad become greater with age. In other instances, IM can be a challenging disease to diagnose, mainly because the patient debuts with unusual symptoms such as nausea, skin eruptions, diarrhea and epigastric discomfort. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jomfp.JOMFP_80_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069135PMC
February 2020

Epstein-Barr Virus Epitope-Major Histocompatibility Complex Interaction Combined with Convergent Recombination Drives Selection of Diverse T Cell Receptor α and β Repertoires.

mBio 2020 03 17;11(2). Epub 2020 Mar 17.

Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

Recognition modes of individual T cell receptors (TCRs) are well studied, but factors driving the selection of TCR repertoires from primary through persistent human virus infections are less well understood. Using deep sequencing, we demonstrate a high degree of diversity of Epstein-Barr virus (EBV)-specific clonotypes in acute infectious mononucleosis (AIM). Only 9% of unique clonotypes detected in AIM persisted into convalescence; the majority (91%) of unique clonotypes detected in AIM were not detected in convalescence and were seeming replaced by equally diverse "" clonotypes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.00250-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078470PMC

Epstein-Barr virus-related encephalitis in a young woman: A case report.

J Infect Chemother 2020 Jul 5;26(7):741-744. Epub 2020 Mar 5.

Department of General Internal Medicine, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan.

Although infectious mononucleosis due to Epstein-Barr virus (EBV) is a common disease among young individuals, central nervous system (CNS) complications are rare. In this report, we describe a case of CNS complications caused by EBV in a previously healthy young woman. She presented to our hospital with a 9-day history of headache and sore throat, followed by the development of fever and facial edema 6 days prior to admission. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jiac.2020.02.005DOI Listing

Young female patient with bilateral periorbital edema.

Eur J Intern Med 2020 May 5;75:93-94. Epub 2020 Mar 5.

Division of Emergency and General Medicine, Tokyo Metropolitan Tama Medical Center, 2-8-29 Musashidai, Fuchu-shi, Tokyo 183-8524, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejim.2020.02.013DOI Listing

Infectious mononucleosis, immune genotypes, and non-Hodgkin lymphoma (NHL): an InterLymph Consortium study.

Cancer Causes Control 2020 May 2;31(5):451-462. Epub 2020 Mar 2.

Department of Preventive Medicine, Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Purpose: We explored the interaction between non-Hodgkin lymphoma (NHL), infectious mononucleosis (IM) history, and immune-related genotypes in a pooled case-control analysis.

Methods: A total of 7,926 NHL patients and 10,018 controls from 12 case-control studies were included. Studies were conducted during various time periods between 1988 and 2008, and participants were 17-96 years of age at the time of ascertainment/recruitment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10552-020-01266-4DOI Listing