9,214 results match your criteria Mononucleosis

[Sucecesfull bone marrow transplantation in a case of familial hemophagocytic lymphohistiocytosis type 3].

Andes Pediatr 2021 Apr;92(2):269-273

Centro de Investigaciones en Anomalías Congénitas y enfermedades Raras, Universidad ICEsI, Cali, Colombia.

Introduction: Hemophagocytic lymphohistiocytosis (HLH) is an exaggerated activation of the immune system which can be either primary (familial) or secondary. Familial hemophagocytic lymphohistiocytosis type 3 (FHL-3) is a severe immune disorder, caused by mutations in the UNC13D gene, which codes for a protein crucial to the cytotoxic function of lymphocytes.

Objective: To describe the diagnostic relevance of next-generation sequencing in the approach of a patient with suspected FHL and to demonstrate the effectiveness of bone marrow transplantation as the only curative measure. Read More

View Article and Full-Text PDF

Study of Surface Activation Markers on CD3 CD16 NK Cells and Their Correlation with Clinical Manifestations in Children with Infectious Mononucleosis.

Microbiol Immunol 2021 Jun 8. Epub 2021 Jun 8.

Wenzhou Medical University Second Affiliated Hospital, China.

This study aimed to investigate the proportion of surface activation markers on natural killer (NK) cells in children with infectious mononucleosis (IM) and to explore its clinical relevance. A total of 17 children hospitalized with IM were included in this study as the experimental group. Meanwhile, healthy children matched for age and gender served as controls. Read More

View Article and Full-Text PDF

Infectious Mononucleosis: A Case Report With Unusual Features and Abnormal Laboratory Findings.

Cureus 2021 May 1;13(5):e14790. Epub 2021 May 1.

Neurology, Universidad San Francisco de Quito, Quito, ECU.

Despite the widespread Epstein-Barr virus (EBV) infections, we continue to see new reports with strange and unusual manifestations of the infection, which raises the question of how well we understand this pathogen. The age of contracting the infection is increasing in developed countries, which is changing the clinical presentation of those who get infected during their adolescence or early adulthood. In these stages, liver involvement is more prominent, and other physical symptoms are less apparent. Read More

View Article and Full-Text PDF

[A Case of Neuromyelitis Optica Spectrum Disorder Who Relapsed Under Oral Corticosteroid Treatment with Multiple Cerebrospinal Lesions and Severe Neurological Deficits].

J UOEH 2021 ;43(2):255-261

Department of Neurology, Kokura Memorial Hospital, Japan.

We present a case of a 59-year-old female who had been treated for optic neuritis 2 years before being transferred to our hospital. She had been positive for anti-AQP4 antibodies. No cerebrospinal lesions were observed, and based on the diagnosis of neuromyelitis optica spectrum disorder (NMOSD), 5 mg/day oral prednisolone was continued for 2 years. Read More

View Article and Full-Text PDF
January 2021

Hsa-miR-372-5p regulates the NIMA related kinase 7 and IL-1β release in NK/T-cell lymphoma.

Leuk Lymphoma 2021 Jun 3:1-9. Epub 2021 Jun 3.

Shenzhen Key Laboratory for Translational Medicine of Dermatology, Biomedical Research Institute, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, China.

Epstein-Barr virus (EBV) infection is prevalent and associated with distinct diseases including infectious mononucleosis (IM), chronic active EBV infection (CAEBV) and NK/T-cell lymphoma (NKTL). However, the specific roles of EBV in these diseases remain unclear. Here, the whole miRNA expression datasets derived from 7 IM, 6 CAEBV, and 3 NKTL biopsies were obtained. Read More

View Article and Full-Text PDF

Political Economies of Acute Childhood Illnesses: Measuring Structural Racism as Mesolevel Mortgage Market Risks.

Ethn Dis 2021 20;31(Suppl 1):319-332. Epub 2021 May 20.

Emory University, Department of Sociology, Atlanta, GA.

Objectives: Health studies of structural racism/discrimination have been animated through the deployment of neighborhood effects frameworks that engage institutionalist concerns about sociopolitical resources and mobility structures. This study highlights the acute illness risks of place-based inequalities and neighborhood-varying race-based inequalities by focusing on access to and the regulation of mortgage markets.

Design: By merging neighborhood data on lending processes from the Home Mortgage Disclosure Act with individual health from the Project on Human Development in Chicago Neighborhoods, this article evaluates the acute childhood illness risks of four mutually inclusive, political economies using multilevel generalized linear models. Read More

View Article and Full-Text PDF

Human Immunodeficiency Virus (HIV) Masquerading as Myopathy and Rhabdomyolysis.

Cureus 2021 Apr 19;13(4):e14559. Epub 2021 Apr 19.

Internal Medicine, Michigan State University at Hurley Medical Center, Flint, USA.

Human immunodeficiency virus (HIV) characteristically presents as a mononucleosis-like prodrome; rhabdomyolysis as a sole manifestation remains a rare finding from infection to seroconversion. A young male with a vague sexual history presented with myopathy progressing rapidly to rhabdomyolysis and renal failure. Acute HIV rarely presents with classic features, and rhabdomyolysis seems to manifest more in younger patients. Read More

View Article and Full-Text PDF

Fatal unexpected death due to X-linked lymphoproliferative disease.

Leg Med (Tokyo) 2021 May 1;52:101900. Epub 2021 May 1.

Department of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, Hubei 430030, PR China. Electronic address:

X-linked lymphoproliferative disease (XLP) is a rare immunodeficiency disease characterized by severe immune disorder and extreme vulnerability to Epstein-Barr virus (EBV) infections. Here we report a 14-month-old Chinese boy presenting with fulminant infectious mononucleosis (FIM) following EBV infection, and died of hepatic failure within one week of disease progression. Postmortem examination revealed icterus, ascites, extensive enlarged mesenteric lymphnodes and hepatosplenomegaly. Read More

View Article and Full-Text PDF

Risk factors evaluation of post-transplant lymphoproliferative disorders after allogeneic haematopoietic stem cell transplantation with comparison between paediatric and adult.

J Clin Pathol 2021 May 19. Epub 2021 May 19.

Pathology, Peking University People's Hospital, Beijing, China.

To describe the clincopathological features and evaluate risk factors of post-transplant lymphoproliferative disorder (PTLD) after allogeneic haematopoietic stem cell transplants (allo-HSCT), with comparison between paediatric and adult .Clinicopathological features of 81 cases of PTLD after allo-HSCT were analysed by histopatholgy, immunohistochemistry and in situ hybridisatioin.The cases included 58 males and 23 females with a median age of 26. Read More

View Article and Full-Text PDF

Detection of Epstein-Barr virus by a rapid and simple accelerated denaturation bubble-mediated strand exchange amplification method.

Anal Methods 2021 Jun 19;13(22):2519-2526. Epub 2021 May 19.

Department of Pathogenic Biology, School of Basic Medicine, College of Life Sciences, Qingdao Nucleic Acid Rapid Testing International Science and Technology Cooperation Base, the Clinical Laboratory Department of the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, P. R. China.

Epstein-Barr Virus (EBV) is a tumor-associated virus naturally transmitted through saliva. This virus is the pathogen of infectious mononucleosis, which is closely related to the occurrence of nasopharyngeal carcinoma (NPC) and childhood lymphoma. Although a majority of EBV infected individuals exhibited good tolerance after primary infection, those who carry a viral load greater than the clinical cutoff value (COV), the upper level in healthy carriers, still suffer a high risk of cancer. Read More

View Article and Full-Text PDF

Acute superior mesenteric vein thrombosis in the setting of cytomegalovirus mononucleosis: a case report and review of the literature.

Lancet Infect Dis 2021 May 14. Epub 2021 May 14.

Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada; Section of General Internal Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada.

Cytomegalovirus is a viral genus of the overarching family Herpesviridae, and is of particular importance because of its relevance to human disease. This association is predominantly due to human cytomegalovirus, a well-studied pathogen. In addition to the mononucleosis syndrome that can occur during acute cytomegalovirus viraemia, this virion has been recurrently implicated as a provoking factor for thromboembolic disease in the published scientific literature. Read More

View Article and Full-Text PDF

Epstein-Barr virus induced haemophagocytic lymphohistiocytosis.

BMJ Case Rep 2021 May 5;14(5). Epub 2021 May 5.

Department of Hematology and Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA.

Haemophagocytic lymphohistiocytosis (HLH) is a rare condition of uncontrolled immune activation as a result of an inherited genetic defect or in response to malignancy, autoimmune disease, rheumatological disease, AIDS infection or post-transplant immunosuppression. Described here is the case of a 19-year-old Caucasian man who presented with complaints of worsening fever, new-onset jaundice and lethargy after failing treatment for suspected infectious mononucleosis. Physical examination was significant for fever and splenomegaly while laboratory results revealed transaminitis, cytopaenia, indirect hyperbilirubinaemia and elevated ferritin, raising the likelihood of both autoimmune haemolytic anaemia and HLH. Read More

View Article and Full-Text PDF

Primary Epstein-Barr virus infection shortly after primary Cytomegalovirus infection: a case report.

J Med Case Rep 2021 May 3;15(1):257. Epub 2021 May 3.

Department of General Internal Medicine 1, Kawasaki Medical School, 2-6-1 Nakasange, Kita-ku, Okayama, 700-8505, Japan.

Background: Infectious mononucleosis (IM) and mononucleosis-like illnesses are common viral infectious diseases which are often accompanied by a high fever, pharyngitis and lymphadenopathy in adults, although such infection in childhood is generally subclinical. Most cases of IM are caused by the Epstein-Barr virus (EBV) or Cytomegalovirus (CMV). However, it is difficult to diagnose IM only with subjective symptoms, and thus EBV and CMV are nearly indistinguishable in clinical practice. Read More

View Article and Full-Text PDF

Chronic myeloid leukemia with a significant increase of monocytes and rare karyotype: A case report and literature review.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Mar;46(3):322-327

Department of Gastroenterology, Changsha Central Hospital, Changsha 410004, China.

Chronic myeloid leukemia with a significant increase of monocytes is rare and difficult to identify from chronic myelo-monocytic leukemia in clinic. A 31-year-old male patient with systemic pain was initially diagnosed as chronic myelo-monocytic leukemia, who was finally diagnosed as chronic myeloid leukemia by fusion gene and chromosome examination. In addition to the typical Ph chromosome, a rare chromosome translocation t(2; 7)(p13; p22) was observed. Read More

View Article and Full-Text PDF

Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women.

Int J Environ Res Public Health 2021 04 13;18(8). Epub 2021 Apr 13.

Department of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY 10032, USA.

Childhood adversities (CAs) and infections may affect the timing of reproductive development. We examined the associations of indicators of CAs and exposure to tonsillitis and infectious mononucleosis (mono) with age at menarche. A multiethnic cohort of 400 women (ages 40-64 years) reported exposure to parental maltreatment and maladjustment during childhood and any diagnosis of tonsillitis and/or mono; infections primarily acquired in early life and adolescence, respectively. Read More

View Article and Full-Text PDF

Development of infectious mononucleosis as an unusual manifestation of COVID-19.

Auris Nasus Larynx 2021 Apr 12. Epub 2021 Apr 12.

Department of Otorhinolaryngology - Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Japan.

It has generally been reported that patients with COVID-19 show a fever, cough, and/or respiratory failure as the most common clinical symptoms but some have unusual symptoms, such as anosmia, diarrhea, and throat pain. We herein report a 26-year-old woman with chief complaints of lymphadenopathy and a fever. First, she underwent a laboratory examination, which showed a high proportion of atypical lymphocytes (19%) and an increase in hepatic enzyme activities, and was then hospitalized with a diagnosis of infectious mononucleosis (IM). Read More

View Article and Full-Text PDF

Cytomegalovirus pneumonia in an immunocompetent host with primary ciliary dyskinesia: A case report.

Monaldi Arch Chest Dis 2021 Apr 22. Epub 2021 Apr 22.

1st Pulmonology Department Sismanogleio Hospital, Athens.

Primary ciliary dyskinesia (PCD) is an autosomal-recessive inherited disease caused by mutations in genes involved in ciliary structure and function leading to impaired mucociliary clearance and repeated or chronic, usually bacterial, infections of the upper and lower airways and decreased lung function and bronchiectasis. Cytomegalovirus (CMV) is a DNA virus that usually causes subclinical infection and in 10% of the patients causes a mononucleosis-like syndrome. CMV is a causative agent of serious illness in vulnerable immunocompromised groups such as transplant recipients, patients with immunodeficiency or malignancy and neonates. Read More

View Article and Full-Text PDF

To Ki or Not to Ki: Re-Evaluating the Use and Potentials of Ki-67 for T Cell Analysis.

Front Immunol 2021 9;12:653974. Epub 2021 Apr 9.

Immunosurveillance Laboratory, The Francis Crick Institute, London, United Kingdom.

This study discusses substantive advances in T cell proliferation analysis, with the aim to provoke a re-evaluation of the generally-held view that Ki-67 is a reliable proliferation marker , and to offer a more sensitive and effective method for T cell cycle analysis, with informative examples in mouse and human settings. We summarize recent experimental work from our labs showing that, by Ki-67/DNA dual staining and refined flow cytometric methods, we were able to identify T cells in the S-G/M phases of the cell-cycle in the peripheral blood (collectively termed "T Double S" for T cells in S-phase : in short "T" cells). Without our refinement, such cells may be excluded from conventional lymphocyte analyses. Read More

View Article and Full-Text PDF

Mindray BC-6800 haematological analyser: 3D-DIFF scattergram usefulness in infectious mononucleosis diagnosis.

Int J Lab Hematol 2021 Apr 23. Epub 2021 Apr 23.

U.O. Patologia Clinica A.O.R.N. "G. Rummo", Benevento, Italy.

Introduction: 3D-DIFF scattergram of the Mindray BC-6800 haematological analyser shows morphological abnormalities and lymphocyte cluster splitting related to the presence of reactive lymphocytes. This study aims to assess whether these cytographic changes are useful in detecting both activated and apoptotic lymphocytes, leading to an improvement in the laboratory diagnostic process of infectious mononucleosis.

Methods: Two hundred three samples with modified shape and doubled lymphocyte cluster of DIFF scattergram (study group) were divided into two different subgroups: with and, respectively, without serological evidence of ongoing IM. Read More

View Article and Full-Text PDF

The Evolving Epidemiology of Nasopharyngeal Carcinoma.

Cancer Epidemiol Biomarkers Prev 2021 Jun 13;30(6):1035-1047. Epub 2021 Apr 13.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Background: The epidemiology of nasopharyngeal carcinoma (NPC) has long been a source of fascination due to the malignancy's striking geographic distribution, the involvement of the oncogenic Epstein-Barr virus (EBV), the unique association with intake of Chinese-style salt-preserved fish, and etiologic heterogeneity by histologic subtype.

Methods: This review summarizes the current epidemiologic literature on NPC, highlighting recent results from our population-based case-control study in southern China.

Results: Findings from our case-control study provide new insight into the epidemiology of NPC, including a diminished role of Chinese-style salt-preserved fish, a profound impact of EBV genetic sequence variation, modest positive associations with passive smoking and household air pollution, and possible effects of oral health and the oral microbiome. Read More

View Article and Full-Text PDF

Immunization with Epstein-Barr Virus Core Fusion Machinery Envelope Proteins Elicit High Titers of Neutralizing Activities and Protect Humanized Mice from Lethal Dose EBV Challenge.

Vaccines (Basel) 2021 Mar 19;9(3). Epub 2021 Mar 19.

The Institute for Vaccine Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and is strongly implicated in the etiology of multiple lymphoid and epithelial cancers. EBV core fusion machinery envelope proteins gH/gL and gB coordinately mediate EBV fusion and entry into its target cells, B lymphocytes and epithelial cells, suggesting these proteins could induce antibodies that prevent EBV infection. We previously reported that the immunization of rabbits with recombinant EBV gH/gL or trimeric gB each induced markedly higher serum EBV-neutralizing titers for B lymphocytes than that of the leading EBV vaccine candidate gp350. Read More

View Article and Full-Text PDF

Gianotti-Crosti syndrome: a challenging exanthema.

BMJ Case Rep 2021 Apr 1;14(4). Epub 2021 Apr 1.

Department of Pediatrics, Centro Hospitalar de Setúbal EPE, Setúbal, Portugal.

Gianotti-Crosti syndrome (GCS) is a self-limited condition, mainly affecting children younger than 6 years, less common in adolescents and adults. It consists of a viral exanthema with papular lesions with a flat top and symmetrical distribution, affecting predominantly extremities, gluteal region and extensor surfaces. It is often associated with viral infections but can also be related to bacterial infections, vaccination or be idiopathic. Read More

View Article and Full-Text PDF

Case of haemophagocytic lymphohistiocytosis following Epstein-Barr virus infection.

BMJ Case Rep 2021 Mar 31;14(3). Epub 2021 Mar 31.

Pulmonary, Critical Care and Sleep Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.

Haemophagocytic lymphohistiocytosis (HLH) is a rare diagnosis that carries a high degree of mortality. We present this case of a previously healthy 22-year-old woman, who was admitted acutely ill to the hospital. One week prior, she had been seen by her primary care physician for fatigue and malaise. Read More

View Article and Full-Text PDF

Infectious Mononucleosis Complicated with Bilateral Peritonsillar Abscess and Splenic Infarction.

Case Rep Infect Dis 2021 12;2021:6623834. Epub 2021 Mar 12.

Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Infectious mononucleosis (IM) due to Epstein-Barr virus (EBV) infection is usually self-limited. It presents with fever, pharyngitis, fatigue, and cervical lymph node enlargement. It is common among adolescents and young adults. Read More

View Article and Full-Text PDF

Sudden and transient livedo reticularis as a manifestation of mononucleosis-like disease by cytomegalovirus.

Clin Exp Dermatol 2021 Mar 19. Epub 2021 Mar 19.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

View Article and Full-Text PDF

An insidious case of infectious mononucleosis presenting with acute appendicitis diagnosed postoperatively: a case report.

J Surg Case Rep 2021 Mar 8;2021(3):rjab039. Epub 2021 Mar 8.

Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City-National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Infectious mononucleosis (IM) is a syndrome caused by the Epstein-Barr virus. IM typically presents with fever, pharyngitis and lymphadenopathy. Rarely, it can cause acute appendicitis. Read More

View Article and Full-Text PDF

Triptolide inhibits human telomerase reverse transcriptase by downregulating translation factors SP1 and c-Myc in Epstein-Barr virus-positive B lymphocytes.

Oncol Lett 2021 Apr 10;21(4):280. Epub 2021 Feb 10.

Department of General Surgery, Jingjiang People's Hospital, Jingjiang, Jiangsu 214500, P.R. China.

Epstein-Barr virus (EBV) mainly causes infectious mononucleosis and is associated with several neoplasms, including Burkitt's lymphoma, nasopharyngeal carcinoma and lymphoproliferative disease. Human telomerase reverse transcriptase (hTERT) regulates enzymatic activity of telomerase and is closely associated with tumorigenesis and senescence evasion. Triptolide (TP) is a diterpenoid triepoxide, with a broad-spectrum anticancer and immunosuppressive bioactivity profile. Read More

View Article and Full-Text PDF


J Paediatr Child Health 2021 03;57(3):459

Department of General Paediatrics, Children's Hospital at Westmead, Sydney, New South Wales, Australia.

View Article and Full-Text PDF