8,904 results match your criteria Mononucleosis


Detection and virulence potential of a phospholipase D-negative Corynebacterium ulcerans from a concurrent diphtheria and infectious mononucleosis case.

Antonie Van Leeuwenhoek 2019 Feb 15. Epub 2019 Feb 15.

Laboratory of Diphtheria and Corynebacteria of Clinical Relevance - Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro - UERJ, Av. 28 de Setembro, 87 - Fundos, 3° andar. Vila Isabel, Rio de Janeiro, RJ, 20.551, Brazil.

Diphtheria by Corynebacterium ulcerans is increasingly occurring in children, adolescents and adults. In addition to diphtheria toxin (DT), phospholipase D (PLD) is considered a virulence factor of C. ulcerans. Read More

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http://dx.doi.org/10.1007/s10482-019-01240-4DOI Listing
February 2019

A Case of EBV-Associated Blastic Lymphoplasmacytic Proliferation in an Esophageal Ulcer with a Self-Limiting Course: Overlapping Lesion between EBV Mucocutaneous Ulcer and Polymorphic Lymphoplasmacytic Disorder.

Histopathology 2019 Feb 6. Epub 2019 Feb 6.

Division of Hematopathology, Department of Pathology and Laboratory Medicine, University of Miami and, Sylvester Comprehensive Cancer Center, Miami, FL.

B cell lymphoproliferative disorders (LPD) of varied malignant potential occur in association with immunodeficiency and include among others, follicular hyperplasia, infectious mononucleosis-like hyperplasia, plasmacytic hyperplasia, polymorphic B-lymphoproliferative disorders and the recently described clinicopathologic entity named as EBV-positive mucocutaneous ulcer (EBV-MCU). EBV-MCU is a localized and usually self-limited EBV-associated LPD characterized by a circumscribed ulcer involving oropharyngeal mucosa, skin, or gastrointestinal tract reported most often in elderly patients with presumed age-associated immunodeficiency. Histologically, EBV-MCU is characterized by a polymorphous infiltrate, which frequently includes atypical large B cells with Hodgkin/Reed-Sternberg (HRS) like cells admixed with abundant reactive T cells usually forming a rim around the base of the lesion. Read More

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http://dx.doi.org/10.1111/his.13836DOI Listing
February 2019
1 Read

Serum amyloid A protein in the course of infectious mononucleosis.

Ther Adv Infect Dis 2019 Jan-Dec;6:2049936118811208. Epub 2019 Jan 17.

Department of General Medicine and Clinical Laboratory, Medical University of Varna, Varna, Bulgaria.

Background: Serum amyloid A (SAA) protein is a major acute phase protein. Increased concentrations have been reported in many inflammatory diseases. In bacterial infections, high levels correlate with those of C-reactive protein (CRP). Read More

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http://dx.doi.org/10.1177/2049936118811208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348571PMC
January 2019

Immunoinformatic and systems biology approaches to predict and validate peptide vaccines against Epstein-Barr virus (EBV).

Sci Rep 2019 Jan 24;9(1):720. Epub 2019 Jan 24.

State Key Laboratory of Microbial Metabolism, and College of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.

Epstein-Barr virus (EBV), also known as human herpesvirus 4 (HHV-4), is a member of the Herpesviridae family and causes infectious mononucleosis, Burkitt's lymphoma, and nasopharyngeal carcinoma. Even in the United States of America, the situation is alarming, as EBV affects 95% of the young population between 35 and 40 years of age. In this study, both linear and conformational B-cell epitopes as well as cytotoxic T-lymphocyte (CTL) epitopes were predicted by using the ElliPro and NetCTL. Read More

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http://www.nature.com/articles/s41598-018-37070-z
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http://dx.doi.org/10.1038/s41598-018-37070-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346095PMC
January 2019
3 Reads
5.078 Impact Factor

The International Collaborative on Fatigue Following Infection (COFFI).

Fatigue 2018 19;6(2):106-121. Epub 2018 Jan 19.

Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.

Background: The purpose of the Collaborative on Fatigue Following Infection (COFFI) is for investigators of post-infection fatigue (PIF) and other syndromes to collaborate on these enigmatic and poorly understood conditions by studying relatively homogeneous populations with known infectious triggers. Utilizing COFFI, pooled data and stored biosamples will support both epidemiological and laboratory research to better understand the etiology and risk factors for development and progression of PIF.

Methods: COFFI consists of prospective cohorts from the UK, Netherlands, Norway, USA, New Zealand and Australia, with some cohorts closed and some open to recruitment. Read More

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https://www.tandfonline.com/doi/full/10.1080/21641846.2018.1
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http://dx.doi.org/10.1080/21641846.2018.1426086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333416PMC
January 2018
5 Reads

Defective Epstein-Barr virus in chronic active infection and haematological malignancy.

Nat Microbiol 2019 Jan 21. Epub 2019 Jan 21.

Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Epstein-Barr virus (EBV) infection is highly prevalent in humans and is implicated in various diseases, including cancer. Chronic active EBV infection (CAEBV) is an intractable disease classified as a lymphoproliferative disorder in the 2016 World Health Organization lymphoma classification. CAEBV is characterized by EBV-infected T/natural killer (NK) cells and recurrent/persistent infectious mononucleosis-like symptoms. Read More

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http://dx.doi.org/10.1038/s41564-018-0334-0DOI Listing
January 2019
15 Reads

Cold type autoimmune hemolytic anemia- a rare manifestation of infectious mononucleosis; serum ferritin as an important biomarker.

BMC Infect Dis 2019 Jan 18;19(1):68. Epub 2019 Jan 18.

Sri Jayawardanapura General Hospital, Thalapathpitiya, Nugegoda, Western province, Sri Lanka.

Background: Infectious mononucleosis is one of the main manifestations of Epstein - Barr virus, which is characterized by fever, tonsillar-pharyngitis, lymphadenopathy and atypical lymphocytes. Although 60% of patients with IMN develop cold type antibodies, clinically significant hemolytic anemia with a high ferritin level is very rare and validity of serum ferritin as an important biomarker has not been used frequently.

Case Presentation: 18-year-old girl presented with fever, malaise and sore throat with asymptomatic anemia, generalized lymphadenopathy, splenomegaly and mild hepatitis. Read More

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http://dx.doi.org/10.1186/s12879-019-3722-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339345PMC
January 2019
3 Reads

MicroRNAs of Epstein-Barr Virus Attenuate T-Cell-Mediated Immune Control .

MBio 2019 Jan 15;10(1). Epub 2019 Jan 15.

Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland

The human persistent and oncogenic Epstein-Barr virus (EBV) was one of the first viruses that were described to express viral microRNAs (miRNAs). These have been proposed to modulate many host and viral functions, but their predominant role has remained unclear. We compared recombinant EBVs expressing or lacking miRNAs during infection of mice with reconstituted human immune system components and found that miRNA-deficient EBV replicates to lower viral titers with decreased frequencies of proliferating EBV-infected B cells. Read More

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http://mbio.asm.org/lookup/doi/10.1128/mBio.01941-18
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http://dx.doi.org/10.1128/mBio.01941-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336420PMC
January 2019
5 Reads

Infectious mononucleosis: be aware of its lethality!

Int J Adolesc Med Health 2019 Jan 12. Epub 2019 Jan 12.

MD, MMedSci, DMSc, Professor of Pediatrics, Department of Pediatrics, Mt Scopus Campus, Hadassah Hebrew University Medical Center and Director, National Institute of Child Health and Human Development, Jerusalem, Israel.

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http://dx.doi.org/10.1515/ijamh-2018-0284DOI Listing
January 2019

CMV-Specific Immune Response-New Patients, New Insight: Central Role of Specific IgG during Infancy and Long-Lasting Immune Deficiency after Allogenic Stem Cell Transplantation.

Int J Mol Sci 2019 Jan 11;20(2). Epub 2019 Jan 11.

Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland.

Although the existing paradigm states that cytomegalovirus (CMV) reactivation is under the control of the cellular immune response, the role of humoral and innate counterparts are underestimated. The study analyzed the host⁻virus interaction i.e. Read More

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http://www.mdpi.com/1422-0067/20/2/271
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http://dx.doi.org/10.3390/ijms20020271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358762PMC
January 2019
6 Reads

[Clinical features of children with Epstein-Barr virus-related acute liver failure: an analysis of four cases].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Dec;20(12):1030-1033

Department of Pediatric Intensive Care Unit, Critical Care Medicine Center of Qingdao Women and Children's Hospital, Qingdao, Shandong 266034, China.

A retrospective analysis was performed for the clinical data of four children with Epstein-Barr virus (EBV)-related acute liver failure. There were two boys and two girls with a median age of 10 months (range 8.5-44 months). Read More

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December 2018
7 Reads

The Epstein-Barr virus induces the expression of the LPAM-1 integrin in B-cells and .

J Virol 2018 Dec 12. Epub 2018 Dec 12.

German Cancer Research Centre (DKFZ) Unit F100, Heidelberg, Germany

The Epstein-Barr virus (EBV) infects the oropharynx but surprisingly frequently induces B-cell proliferations in the gut of immunosuppressed individuals. We found that EBV infection induces the expression of the LPAM-1 integrin on tonsillar B cells and increases it on peripheral blood cells. Similarly, LPAM-1 was induced in the tonsils of patients undergoing primary infectious mononucleosis. Read More

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http://dx.doi.org/10.1128/JVI.01618-18DOI Listing
December 2018
2 Reads
4.439 Impact Factor

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to imaging.

Neural Regen Res 2019 Mar;14(3):373-386

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences; Center for Biomedical Imaging at Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA.

Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation, demyelination, and neuronal damage. Environmental and genetic factors are associated with the risk of developing MS, but the exact cause still remains unidentified. Epstein-Barr virus (EBV), vitamin D, and smoking are among the most well-established environmental risk factors in MS. Read More

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http://www.nrronline.org/text.asp?2019/14/3/373/245462
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http://dx.doi.org/10.4103/1673-5374.245462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334604PMC
March 2019
6 Reads

[Epstein-Barr virus primary infection in healthy children].

An Pediatr (Barc) 2018 Oct 24. Epub 2018 Oct 24.

Servicio de Pediatría, Hospital Lluís Alcanyís, Xátiva, Valencia, España.

Introduction: The aim of this study is to assess epidemiological, clinical and laboratory characteristics of primary infection by Epstein-Barr virus (EBV) in children without previous diagnosis of any immune disease and its relationship with clinical presentation.

Patients And Methods: A retrospective study was conducted on all children from 0 to 15 years with IgM against viral capsid of EBV positive or indeterminate during a 22 month period. Epidemiological, clinical and laboratory data were analysed and compared between typical (mononucleosis syndrome) and non-typical clinical symptoms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S16954033183034
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http://dx.doi.org/10.1016/j.anpedi.2018.09.003DOI Listing
October 2018
7 Reads

Immunogenic particles with a broad antigenic spectrum stimulate cytolytic T cells and offer increased protection against EBV infection ex vivo and in mice.

PLoS Pathog 2018 12 6;14(12):e1007464. Epub 2018 Dec 6.

German Cancer Research Center (DKFZ) Unit F100, Heidelberg, Germany.

The ubiquitous Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and is etiologically linked to the development of several malignancies and autoimmune diseases. EBV has a multifaceted life cycle that comprises virus lytic replication and latency programs. Considering EBV infection holistically, we rationalized that prophylactic EBV vaccines should ideally prime the immune system against lytic and latent proteins. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298685PMC
December 2018
2 Reads

Acute Epstein-Barr virus-positive cytotoxic T cell lymphoid hyperplasia in the upper aerodigestive tract, mimicking extranodal natural killer/T cell lymphoma, nasal type.

Virchows Arch 2019 Feb 28;474(2):219-226. Epub 2018 Nov 28.

Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.

To describe the clinicopathological features of nine patients with acute Epstein-Barr virus (EBV)-positive cytotoxic T cell lymphoid hyperplasia (EBV+TLH) in the upper aerodigestive tract, in which initial findings led to a preliminary misdiagnosis of extranodal NK/T cell lymphoma, nasal type (ENKTL). A series of nine cases of EBV+TLH in one Chinese institution over a 9-year interval was retrospectively analyzed. Median age was 16 years (range 5-29 years) with a M:F ratio of 5:4. Read More

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http://dx.doi.org/10.1007/s00428-018-2498-7DOI Listing
February 2019
2 Reads

Complex Investigation of a Pediatric Haematological Case: Haemophagocytic Syndrome Associated with Visceral Leishmaniasis and Epstein⁻Barr (EBV) Co-Infection.

Int J Environ Res Public Health 2018 11 27;15(12). Epub 2018 Nov 27.

Department of Surgical and Biomedical Sciences, Paediatric Clinic, Università degli Studi di Perugia, 06132 Perugia, Italy.

Background: Visceral leishmaniasis (VL) is an anthropozoonosis caused by an intracellular parasite belonging to the genus . In the Mediterranean region, and are responsible for VL and dogs are the main reservoir. Haemophagocytic lymphohistiocytosis (HLH) represents a complication of VL and consists of unrestrained activation and proliferation of lymphocytes and macrophages, leading to uncontrolled immune activation. Read More

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http://dx.doi.org/10.3390/ijerph15122672DOI Listing
November 2018
1 Read

Epstein-Barr virus and skin.

An Bras Dermatol 2018 Nov/Dec;93(6):786-799

Hospital Cayetano Heredia, Lima, Peru.

Epstein-Barr virus is a DNA virus infecting human beings and could affect 90% of human population. It is crucial to take in account that in Latin America, unlike what happens in developed countries, the exposure to the virus is very early and therefore people have a much longer interaction with the virus. The virus is related to many diseases, mainly the oncological ones, and when the onset is in cutaneous tissue, it can present many clinical variants, as well acute as chronic ones. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20187021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256212PMC
February 2019
7 Reads

Infections of the Oropharynx.

Authors:
Matthew R Klein

Emerg Med Clin North Am 2019 Feb;37(1):69-80

Department of Emergency Medicine, Northwestern University, 211 East Ontario - Suite 300, Chicago, IL 60611, USA. Electronic address:

This article reviews the presentation, diagnosis, and management of common and "can't miss" infections of the oropharynx, including streptococcal pharyngitis, infectious mononucleosis, peritonsillar abscess, retropharyngeal abscess, and epiglottitis. Read More

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http://dx.doi.org/10.1016/j.emc.2018.09.002DOI Listing
February 2019
4 Reads

Acute gastritis caused by concurrent infection with Epstein-Barr virus and cytomegalovirus in an immunocompetent adult.

Clin J Gastroenterol 2018 Nov 16. Epub 2018 Nov 16.

Department of Diagnostic Pathology, Anjo Kosei Hospital, 28 Higashi-hirokute, Anjo-cho, Anjo, Aichi, 446-8602, Japan.

Herein, we describe an extremely rare case of gastritis due to concurrent infection with Epstein-Barr virus (EBV) and cytomegalovirus (CMV) occurring in an immunocompetent adult. The patient was a 35-year-old man who presented with slight fever, nausea, anorexia, weight loss for 3 weeks, mild transaminitis, and leukocytosis with atypical lymphocytes in peripheral blood. The clinical presentation and elevated IgM titers to both EBV-VCA and CMV strongly suggested infectious mononucleosis syndrome caused by co-infection with EBV and CMV. Read More

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http://link.springer.com/10.1007/s12328-018-0924-7
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http://dx.doi.org/10.1007/s12328-018-0924-7DOI Listing
November 2018
15 Reads

Mononucleosis: A Possible Cause of Idiopathic Hypersomnia.

Front Neurol 2018 31;9:922. Epub 2018 Oct 31.

Service de Physiologie Clinique et de l'Exercice (Pole Hospitalier NOL), CHU Nord, Faculté de Médecine Jacques Lisfranc, Université Jean Monnet, SNA EPIS EA 4607, Université de Lyon, Saint-Étienne, France.

Idiopathic hypersomnia (IH) is a rare central hypersomnia of unknown physiopathology. In this study, we determine if the presence of infectious mononucleosis evaluated by serological markers of Epstein Barr virus infection plays a role in this hypersomnia. Ten patients with a suspicion of IH underwent to clinical assessment, 24 h polysomnography, and serologic testing for mononucleosis including Viral Capside Antigen (VCA) IgG, the VCA IgM, and the EBV nuclear antigen (EBNA). Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.00922
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http://dx.doi.org/10.3389/fneur.2018.00922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220045PMC
October 2018
8 Reads

Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity.

Nat Microbiol 2019 Jan 12;4(1):78-88. Epub 2018 Nov 12.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.

The apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like (APOBEC) family of single-stranded DNA (ssDNA) cytosine deaminases provides innate immunity against virus and transposon replication. A well-studied mechanism is APOBEC3G restriction of human immunodeficiency virus type 1, which is counteracted by a virus-encoded degradation mechanism. Accordingly, most work has focused on retroviruses with obligate ssDNA replication intermediates and it is unclear whether large double-stranded DNA (dsDNA) viruses may be similarly susceptible to restriction. Read More

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http://www.nature.com/articles/s41564-018-0284-6
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http://dx.doi.org/10.1038/s41564-018-0284-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294688PMC
January 2019
28 Reads

Emergence of Cytomegalovirus Mononucleosis Syndrome Among Young Adults in Hong Kong Linked to Falling Seroprevalence: Results of a 14-Year Seroepidemiological Study.

Open Forum Infect Dis 2018 Oct 20;5(10):ofy262. Epub 2018 Oct 20.

Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam.

Background: Cytomegalovirus (CMV) mononucleosis is a manifestation of primary CMV infection. This study aims to establish the link between long-term population CMV seroepidemiological trends and incidence of CMV mononucleosis requiring hospitalization. Furthermore, by analyzing serial laboratory data of patients hospitalized with CMV mononucleosis, we aim to provide insights into the natural history of this syndrome. Read More

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https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofy26
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http://dx.doi.org/10.1093/ofid/ofy262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204993PMC
October 2018
14 Reads

2B4 dysfunction in XLP1 NK cells: More than inability to control EBV infection.

Clin Immunol 2018 Nov 2. Epub 2018 Nov 2.

IRCCS Istituto Giannina Gaslini, Dipartimento dei Laboratori di Ricerca, Genoa, Italy; Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genoa, Italy.

X-linked lymphoproliferative disease 1 (XLP1) is a monogenic disorder caused by mutations in SH2D1A, resulting in the absence/dysfunction of the signaling lymphocyte activation molecule (SLAM)-associated protein (SAP). Consequently, SLAM receptors as 2B4 (CD244) and NTB-A (SLAMF6), upon ligand engagement, exert inhibitory instead of activating function. This causes an immune dysfunction that is worsened by the selective inability of NK and T cells to kill EBV-infected B cells with dramatic clinical sequelae (e. Read More

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http://dx.doi.org/10.1016/j.clim.2018.10.022DOI Listing
November 2018

Lung transplantation as a viable option of treatment for pulmonary veno-occlusive disease.

Adv Respir Med 2018 ;86(5):249-254

Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, SDMZ in Zabrze, Medical University of Silesia in Katowice, Silesian Centre for Heart Disease in Zabrze, Poland.

Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension caused by alteration of pulmonary veins. Many clinical and hemodynamic similarities to idiopathic pulmonary arterial hypertension (IPAH) may cause diagnostic and therapeutic difficulties. This case report is about a patient with PVOD, whose first symptoms of the disease occurred after infectious mononucleosis. Read More

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https://journals.viamedica.pl/advances_in_respiratory_medici
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http://dx.doi.org/10.5603/ARM.2018.0040DOI Listing
January 2018
12 Reads

Infectious mononucleosis.

JAAPA 2018 Nov;31(11):52-53

Joel Schwartzkopf practices at Colorado State University Health Network in Fort Collins, Colo. The author has disclosed no potential conflicts of interest, financial or otherwise.

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http://dx.doi.org/10.1097/01.JAA.0000546488.73851.ddDOI Listing
November 2018

Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis.

Case Rep Crit Care 2018 25;2018:9756050. Epub 2018 Sep 25.

Caserta Hospital, Department of Anesthesia and Intensive Care, Italy.

The authors describe the case of a young woman who developed a clinical pictures resembling a septic shock-related multiple organ dysfunction syndrome a couple of months after having been diagnosed suffering from a hemophagocytic lymphohistiocytosis associated with an infectious mononucleosis. Despite the aggressive treatment, which included antibiotics, vasopressors, IV immunoglobulins, and the use of an extracorporeal device aimed to remove mediators released both during sepsis and the cytokine storm determined by the hemophagocytic lymphohistiocytosis, the patient died. At the autopsy, an extremely uncommon aggressive lymphoma of Epstein-Barr virus-positive T-lymphocytes with systemic involvement was discovered. Read More

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http://dx.doi.org/10.1155/2018/9756050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176343PMC
September 2018
2 Reads

How Safe is It to Prescribe Cephalosporins in Patients with Infectious Mononucleosis? Implications for Clinical ENT Practice.

Turk Arch Otorhinolaryngol 2018 Sep 1;56(3):183-184. Epub 2018 Sep 1.

Medical Student, Athens University, Athens, Greece.

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http://dx.doi.org/10.5152/tao.2018.3427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177495PMC
September 2018

S-S-PEG-COOH Self-Assembled Monolayer on Gold Surface Enabled a Combined Assay for Serological EBV Antibody Isotypes.

Proteomics Clin Appl 2018 Oct 11:e1800067. Epub 2018 Oct 11.

Department of Pathology, Anhui Medical University, Hefei, 230032, China.

Purpose: Epstein-Barr virus (EBV) is a ubiquitous human gamma herpes virus that infects human epithelial cells and B lymphocytes. It would be potentially valuable to develop novel combined assays to benefit screening for large panels of samples of EBV infectious diseases.

Experimental Design: A simple antigen-probed biochip that is modified with S-S-PEG-COOH and is used as a label-free high-throughput screening method for a combined detection of EBV capsid antigen IgM antibody, capsid antigen IgG antibody, and nuclear antigen IgG antibody. Read More

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http://doi.wiley.com/10.1002/prca.201800067
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http://dx.doi.org/10.1002/prca.201800067DOI Listing
October 2018
14 Reads

[Common causes of infectious mononucleosis].

Rev Med Suisse 2018 Oct;14(622):1799-1802

Service des maladies infectieuses, Institut Central des Hôpitaux, Hôpital du Valais, Avenue du Grand-Champsec 86, 1950 Sion.

Most cases of infectious mononucleosis are caused by Epstein-Barr virus (EBV). However, other rare but potentially serious etiologies need to be considered. Cytomegalovirus (CMV) and Toxoplasma gondii infections, although generally benign, can cause severe congenital infections. Read More

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October 2018
7 Reads

Mononucleosis-related fatigue: supplementary management with Robuvit®.

Minerva Pediatr 2018 10;70(5):425-429

IRVINE3 Labs, Department of Medical and Oral Sciences, and Biotechnologies, G. D'Annunzio University, Chieti-Pescara, Italy.

Background: Infectious mononucleosis (IM) is a common disease of adolescents and young adults, characterized by a specific triad of symptoms represented by fever, sore throat and lymphadenopathy. IM may also affect older adults, with different, more intense signs and symptoms such as fatigue, general malaise, and diffuse body pain. The aim of this four-week-registry study was to evaluate the effects of Robuvit® supplementation on the main consequences of mononucleosis, particularly fatigue, in otherwise healthy adults. Read More

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https://www.minervamedica.it/index2.php?show=R15Y2018N05A042
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http://dx.doi.org/10.23736/S0026-4946.18.05213-1DOI Listing
October 2018
13 Reads

The rational specimen for the quantitative detection of Epstein-Barr virus DNA load.

Clin Chem Lab Med 2018 Sep 29. Epub 2018 Sep 29.

Department of Clinical Laboratory, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.

Background Epstein-Barr virus (EBV) DNA load monitoring in blood is essential for the diagnosis of EBV-associated diseases. However, the best-suited blood compartment for detection is still under discussion. The aim of this study was to evaluate the diagnostic value of EBV-DNA load in peripheral blood mononuclear cells (PBMC), plasma and whole blood (WB) samples. Read More

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http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-201
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http://dx.doi.org/10.1515/cclm-2018-0733DOI Listing
September 2018
10 Reads

Predictors of chronic fatigue in adolescents six months after acute Epstein-Barr virus infection: A prospective cohort study.

Brain Behav Immun 2019 Jan 25;75:94-100. Epub 2018 Sep 25.

Institute of Clinical Medicine, University of Oslo, Norway; Dept. of Pediatrics, Akershus University Hospital, Norway. Electronic address:

Introduction: Acute Epstein-Barr virus (EBV) infection is a trigger of chronic fatigue and Chronic Fatigue Syndrome (CFS). This study investigated baseline predictors of chronic fatigue six months after an acute EBV infection.

Materials And Methods: A total of 200 adolescents (12-20 years old) with acute EBV infection were assessed for 149 possible baseline predictors and followed prospectively. Read More

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http://dx.doi.org/10.1016/j.bbi.2018.09.023DOI Listing
January 2019
5 Reads

Proteome-wide analysis of CD8+ T cell responses to EBV reveals differences between primary and persistent infection.

PLoS Pathog 2018 09 24;14(9):e1007110. Epub 2018 Sep 24.

Institute for Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

Human herpesviruses are antigenically rich agents that induce strong CD8+T cell responses in primary infection yet persist for life, continually challenging T cell memory through recurrent lytic replication and potentially influencing the spectrum of antigen-specific responses. Here we describe the first lytic proteome-wide analysis of CD8+ T cell responses to a gamma1-herpesvirus, Epstein-Barr virus (EBV), and the first such proteome-wide analysis of primary versus memory CD8+ T cell responses to any human herpesvirus. Primary effector preparations were generated directly from activated CD8+ T cells in the blood of infectious mononucleosis (IM) patients by in vitro mitogenic expansion. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171963PMC
September 2018
1 Read

EBV VCA IgM and cytomegalovirus IgM dual positivity is a false positive finding related to age and hepatic involvement of primary Epstein-Barr virus infection in children.

Medicine (Baltimore) 2018 Sep;97(38):e12380

Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam.

Primary Epstein-Barr virus (EBV) infection is common in childhood, and dual positivity of serum EBV IgM and cytomegalovirus (CMV) IgM antibodies occur in some cases. This study aimed to evaluate the cause of EBV and CMV IgM dual positivity to determine whether it represents a false-positive finding or a true coinfection.A total of 494 children diagnosed with primary EBV infection, manifesting as infectious mononucleosis, were recruited. Read More

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http://Insights.ovid.com/crossref?an=00005792-201809210-0004
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http://dx.doi.org/10.1097/MD.0000000000012380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160097PMC
September 2018
2 Reads

Fatal Chronic Active Epstein-Barr Virus Infection in a Rheumatoid Arthritis Patient Treated with Abatacept.

Intern Med 2019 Feb 12;58(4):585-591. Epub 2018 Sep 12.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

Chronic active Epstein-Barr virus (CAEBV) T-cell type infection, systemic form, is characterized by persistent infectious mononucleosis-like symptoms, high Epstein-Barr virus (EBV) DNA levels in the peripheral blood, organ damage, and a poor prognosis. The association between CAEBV and rheumatoid arthritis (RA) is unclear. We report a case of fatal CAEBV T-cell type infection in an RA patient undergoing treatment with cytotoxic T-lymphocyte-associated antigen 4 immunoglobulin fusion protein (abatacept, ABT). Read More

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http://dx.doi.org/10.2169/internalmedicine.1280-18DOI Listing
February 2019
2 Reads

The sequence analysis of Epstein-Barr virus EBNA1 gene: could viral screening markers for nasopharyngeal carcinoma be identified?

Med Microbiol Immunol 2019 Feb 10;208(1):81-88. Epub 2018 Sep 10.

Virology Department, Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Dr Subotica, Belgrade, 11000, Serbia.

Epstein-Barr virus (EBV) has been identified as a group 1 carcinogenic agent, particularly for nasopharyngeal carcinoma (NPC). The sequence diversity of EBV nuclear antigen 1 (EBNA1) reflects region-restricted polymorphisms, which may be associated with the development of certain malignancies. The aims of the present study were to evaluate EBV EBNA1 gene polymorphisms circulating in NPC, infectious mononucleosis, and isolates from patients with transplanted organs to determine if EBNA1 sequence specificities are useful as viral biomarkers for NPC. Read More

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http://link.springer.com/10.1007/s00430-018-0561-2
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http://dx.doi.org/10.1007/s00430-018-0561-2DOI Listing
February 2019
28 Reads

Cytomegalovirus acute infection with pulmonary involvement in an immunocompetent patient.

IDCases 2018 30;14:e00445. Epub 2018 Aug 30.

Infectious Disease Department, Centro Hospitalar do Porto, Portugal.

Introduction: Cytomegalovirus (CMV) infection in healthy adults is usually asymptomatic or causes a mild mononucleosis syndrome, while severe infections are rare in immunocompetent patients and poorly documented. When described, gastrointestinal tract and the central nervous systems are the most frequent sites of severe CMV infection. Lung disease can occur, but it's rare. Read More

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http://dx.doi.org/10.1016/j.idcr.2018.e00445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125764PMC
August 2018
3 Reads

Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme-like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report.

Exp Ther Med 2018 Sep 6;16(3):2060-2065. Epub 2018 Jul 6.

Department of Hematology and Oncology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, P.R. China.

Angioimmunoblastic T cell lymphoma (AITL)-associated hemophagocytic lymphohistiocytosis (HLH) rarely occurs with annular erythema multiforme-like rashes. The present case report describes a patient who was misdiagnosed with erythema multiforme at an early stage of the disease due to annular erythema multiforme-like eruptions. However, antihistamine treatment was ineffective. Read More

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http://dx.doi.org/10.3892/etm.2018.6420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122190PMC
September 2018
3 Reads

Mumps presenting with unilateral, synchronous parotid and submandibular gland swelling.

BMJ Case Rep 2018 Sep 4;2018. Epub 2018 Sep 4.

Department of Otolaryngology, NHS Lothian, Edinburgh, UK.

A previously healthy 22-year-old woman presented with acute, unilateral facial and neck swelling, associated with fever and malaise. She was initially treated with intravenous antibiotics; however, CT imaging showed unilateral, synchronous swelling and inflammation of the parotid and submandibular glands, and a PCR swab from the parotid duct was positive for mumps. She was fully immunised and had no contact in the preceding period with anyone diagnosed with mumps. Read More

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http://dx.doi.org/10.1136/bcr-2018-226547DOI Listing
September 2018
15 Reads

Infectious Mononucleosis and Lyme Disease as Confounding Diagnoses: A Report of 2 Cases.

Clin Med Res 2018 Dec 30;16(3-4):66-68. Epub 2018 Aug 30.

Integrated Research and Development Laboratory, Marshfield Clinic Research Institute, Marshfield, WI, USA

Lyme disease and infectious mononucleosis are common illnesses that share similar clinical presentations. Significant cross-reactivity is known to occur between Lyme and EBV serologic assays complicating the diagnosis. To date, no prior cases of concurrent acute Lyme and EBV infections have been reported. Read More

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http://dx.doi.org/10.3121/cmr.2018.1419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306145PMC
December 2018
10 Reads

Primary Epstein-Barr virus infection in immunocompetent patients with acute transverse myelitis and a combination of polyradiculitis and anterior horn syndrome as neurological manifestations.

BMJ Case Rep 2018 Aug 29;2018. Epub 2018 Aug 29.

Department of Neurology, Tergooi, Blaricum, The Netherlands.

Neurological manifestations of a primary Epstein-Barr virus (EBV) infection are rare. We describe a case with acute transverse myelitis and another case with a combination of polyradiculitis and anterior horn syndrome as manifestations of a primary EBV infection.The first case is a 50-year-old immunocompetent male diagnosed with acute transverse myelitis, 2 weeks after he was clinically diagnosed with infectious mononucleosis. Read More

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http://dx.doi.org/10.1136/bcr-2018-225333DOI Listing
August 2018
3 Reads

Sustained influence of infections on prostate-specific antigen concentration: An analysis of changes over 10 years of follow-up.

Prostate 2018 Sep 30;78(13):1024-1034. Epub 2018 May 30.

Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.

Background: To extend our previous observation of a short-term rise in prostate-specific antigen (PSA) concentration, a marker of prostate inflammation and cell damage, during and immediately following sexually transmitted and systemic infections, we examined the longer-term influence of these infections, both individually and cumulatively, on PSA over a mean of 10 years of follow-up in young active duty U.S. servicemen. Read More

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http://doi.wiley.com/10.1002/pros.23660
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http://dx.doi.org/10.1002/pros.23660DOI Listing
September 2018
10 Reads

A Rare Presentation of Epstein-Barr Virus-induced Hepatitis With an Interesting Twist: A Case Report Involving a Clinical Pearl.

Cureus 2018 Jun 14;10(6):e2808. Epub 2018 Jun 14.

Internal Medicine, Palisades Medical Center, New Jersey, USA.

An Epstein-Barr Virus (EBV) infection generally presents with the classic infectious mononucleosis symptomatology-sore throat, lymph node enlargement, and fatigue. However, there are cases in which induced hepatitis does occur. The liver enzymes leaked during the acute damage would be apparent in the serum as an elevation of transaminases and alkaline phosphatase. Read More

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https://www.cureus.com/articles/12666-a-rare-presentation-of
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http://dx.doi.org/10.7759/cureus.2808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093274PMC
June 2018
15 Reads

Identification of Urine Metabolites as Biomarkers of Early Lyme Disease.

Sci Rep 2018 Aug 15;8(1):12204. Epub 2018 Aug 15.

Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, United States of America.

Metabolites detectible in human biofluids are attractive biomarkers for the diagnosis of early Lyme disease (ELD), a vector-borne infectious disease. Urine represents an easily obtained clinical sample that can be applied for diagnostic purposes. However, few studies have explored urine for biomarkers of ELD. Read More

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http://dx.doi.org/10.1038/s41598-018-29713-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093930PMC
August 2018
25 Reads

Sequence Variation of Epstein-Barr Virus: Viral Types, Geography, Codon Usage, and Diseases.

J Virol 2018 Nov 29;92(22). Epub 2018 Oct 29.

Section of Virology, Faculty of Medicine, Norfolk Place, London, United Kingdom

One hundred thirty-eight new Epstein-Barr virus (EBV) genome sequences have been determined. One hundred twenty-five of these and 116 from previous reports were combined to produce a multiple-sequence alignment of 241 EBV genomes, which we have used to analyze variation within the viral genome. The type 1/type 2 classification of EBV remains the major form of variation and is defined mostly by EBNA2 and EBNA3, but the type 2 single-nucleotide polymorphisms (SNPs) at the EBNA3 locus extend into the adjacent gp350 and gp42 genes, whose products mediate infection of B cells by EBV. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.01132-18
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http://dx.doi.org/10.1128/JVI.01132-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206488PMC
November 2018
28 Reads

[Diagnostic Value of Combined Detection of HLA-G and IL-6 in Children with Infectious Mononucleosis].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Aug;26(4):1210-1214

Department of Laboratorial Medicine,Wuhan Central Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430016, Hubei Province, China. E-mail:

Objective: To investigate the diagnostic value of combined detection of HLA-G and IL-6 in children with infectious mononucleosis (IM).

Methods: Eighty-three children suffered from infectious mononucleosis hospitalized in Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital) from January 2014 to June 2017 were selected as the IM group, 83 healthy children in the same period were selected as the as control group. Enzyme-linked in munosorbent assay (ELISA) was used to detect and compare the changes of HLA-G and IL-6 levels between 2 groups. Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2018.04.044DOI Listing
August 2018
7 Reads

Fulminant descending mediastinitis secondary to infectious mononucleosis.

Authors:
G W Fuller J N Rao

J Surg Case Rep 2018 Aug 7;2018(8):rjy203. Epub 2018 Aug 7.

Department of Cardiothoracic Surgery, Northern General Hospital, Herries Road, Sheffield, UK.

Descending mediastinitis is a rare, life-threatening condition caused by contiguous spread of oropharyngeal or cervical infection into the mediastinum. Infectious mononucleosis generally results in a self-limited illness characterized by fever, pharyngitis and lymphadenopathy. We present an exceptional case of an 18-year-old with infectious mononucleosis complicated by progressive bacterial superinfection and fulminant descending mediastinitis. Read More

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http://dx.doi.org/10.1093/jscr/rjy203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080047PMC
August 2018
3 Reads

A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination.

Mult Scler 2018 Aug 7:1352458518793524. Epub 2018 Aug 7.

National Centre for Epidemiology & Population Health, Research School of Population Health, The Australian National University, Canberra, ACT, Australia/Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, WA, Australia.

Background: The evidence associating diet and risk of multiple sclerosis is inconclusive.

Objective: We investigated associations between dietary patterns and risk of a first clinical diagnosis of central nervous system demyelination, a common precursor to multiple sclerosis.

Methods: We used data from the 2003-2006 Ausimmune Study, a case-control study examining environmental risk factors for a first clinical diagnosis of central nervous system demyelination, with participants matched on age, sex and study region. Read More

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http://dx.doi.org/10.1177/1352458518793524DOI Listing
August 2018
2 Reads