8,888 results match your criteria Mononucleosis
PLoS Pathog 2018 Dec 6;14(12):e1007464. Epub 2018 Dec 6.
German Cancer Research Center (DKFZ) Unit F100, Heidelberg, Germany.
The ubiquitous Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and is etiologically linked to the development of several malignancies and autoimmune diseases. EBV has a multifaceted life cycle that comprises virus lytic replication and latency programs. Considering EBV infection holistically, we rationalized that prophylactic EBV vaccines should ideally prime the immune system against lytic and latent proteins. Read More
Virchows Arch 2018 Nov 28. Epub 2018 Nov 28.
Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.
To describe the clinicopathological features of nine patients with acute Epstein-Barr virus (EBV)-positive cytotoxic T cell lymphoid hyperplasia (EBV+TLH) in the upper aerodigestive tract, in which initial findings led to a preliminary misdiagnosis of extranodal NK/T cell lymphoma, nasal type (ENKTL). A series of nine cases of EBV+TLH in one Chinese institution over a 9-year interval was retrospectively analyzed. Median age was 16 years (range 5-29 years) with a M:F ratio of 5:4. Read More
Int J Environ Res Public Health 2018 Nov 27;15(12). Epub 2018 Nov 27.
Department of Surgical and Biomedical Sciences, Paediatric Clinic, Università degli Studi di Perugia, 06132 Perugia, Italy.
Background: Visceral leishmaniasis (VL) is an anthropozoonosis caused by an intracellular parasite belonging to the genus . In the Mediterranean region, and are responsible for VL and dogs are the main reservoir. Haemophagocytic lymphohistiocytosis (HLH) represents a complication of VL and consists of unrestrained activation and proliferation of lymphocytes and macrophages, leading to uncontrolled immune activation. Read More
An Bras Dermatol 2018 Nov/Dec;93(6):786-799
Hospital Cayetano Heredia, Lima, Peru.
Epstein-Barr virus is a DNA virus infecting human beings and could affect 90% of human population. It is crucial to take in account that in Latin America, unlike what happens in developed countries, the exposure to the virus is very early and therefore people have a much longer interaction with the virus. The virus is related to many diseases, mainly the oncological ones, and when the onset is in cutaneous tissue, it can present many clinical variants, as well acute as chronic ones. Read More
Emerg Med Clin North Am 2019 Feb;37(1):69-80
Department of Emergency Medicine, Northwestern University, 211 East Ontario - Suite 300, Chicago, IL 60611, USA. Electronic address:
This article reviews the presentation, diagnosis, and management of common and "can't miss" infections of the oropharynx, including streptococcal pharyngitis, infectious mononucleosis, peritonsillar abscess, retropharyngeal abscess, and epiglottitis. Read More
Clin J Gastroenterol 2018 Nov 16. Epub 2018 Nov 16.
Department of Diagnostic Pathology, Anjo Kosei Hospital, 28 Higashi-hirokute, Anjo-cho, Anjo, Aichi, 446-8602, Japan.
Herein, we describe an extremely rare case of gastritis due to concurrent infection with Epstein-Barr virus (EBV) and cytomegalovirus (CMV) occurring in an immunocompetent adult. The patient was a 35-year-old man who presented with slight fever, nausea, anorexia, weight loss for 3 weeks, mild transaminitis, and leukocytosis with atypical lymphocytes in peripheral blood. The clinical presentation and elevated IgM titers to both EBV-VCA and CMV strongly suggested infectious mononucleosis syndrome caused by co-infection with EBV and CMV. Read More
Front Neurol 2018 31;9:922. Epub 2018 Oct 31.
Service de Physiologie Clinique et de l'Exercice (Pole Hospitalier NOL), CHU Nord, Faculté de Médecine Jacques Lisfranc, Université Jean Monnet, SNA EPIS EA 4607, Université de Lyon, Saint-Étienne, France.
Idiopathic hypersomnia (IH) is a rare central hypersomnia of unknown physiopathology. In this study, we determine if the presence of infectious mononucleosis evaluated by serological markers of Epstein Barr virus infection plays a role in this hypersomnia. Ten patients with a suspicion of IH underwent to clinical assessment, 24 h polysomnography, and serologic testing for mononucleosis including Viral Capside Antigen (VCA) IgG, the VCA IgM, and the EBV nuclear antigen (EBNA). Read More
Nat Microbiol 2018 Nov 12. Epub 2018 Nov 12.
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
The apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like (APOBEC) family of single-stranded DNA (ssDNA) cytosine deaminases provides innate immunity against virus and transposon replication. A well-studied mechanism is APOBEC3G restriction of human immunodeficiency virus type 1, which is counteracted by a virus-encoded degradation mechanism. Accordingly, most work has focused on retroviruses with obligate ssDNA replication intermediates and it is unclear whether large double-stranded DNA (dsDNA) viruses may be similarly susceptible to restriction. Read More
Open Forum Infect Dis 2018 Oct 20;5(10):ofy262. Epub 2018 Oct 20.
Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam.
Background: Cytomegalovirus (CMV) mononucleosis is a manifestation of primary CMV infection. This study aims to establish the link between long-term population CMV seroepidemiological trends and incidence of CMV mononucleosis requiring hospitalization. Furthermore, by analyzing serial laboratory data of patients hospitalized with CMV mononucleosis, we aim to provide insights into the natural history of this syndrome. Read More
Clin Immunol 2018 Nov 2. Epub 2018 Nov 2.
IRCCS Istituto Giannina Gaslini, Dipartimento dei Laboratori di Ricerca, Genoa, Italy; Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genoa, Italy.
X-linked lymphoproliferative disease 1 (XLP1) is a monogenic disorder caused by mutations in SH2D1A, resulting in the absence/dysfunction of the signaling lymphocyte activation molecule (SLAM)-associated protein (SAP). Consequently, SLAM receptors as 2B4 (CD244) and NTB-A (SLAMF6), upon ligand engagement, exert inhibitory instead of activating function. This causes an immune dysfunction that is worsened by the selective inability of NK and T cells to kill EBV-infected B cells with dramatic clinical sequelae (e. Read More
Adv Respir Med 2018 ;86(5):249-254
Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, SDMZ in Zabrze, Medical University of Silesia in Katowice, Silesian Centre for Heart Disease in Zabrze, Poland.
Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension caused by alteration of pulmonary veins. Many clinical and hemodynamic similarities to idiopathic pulmonary arterial hypertension (IPAH) may cause diagnostic and therapeutic difficulties. This case report is about a patient with PVOD, whose first symptoms of the disease occurred after infectious mononucleosis. Read More
JAAPA 2018 Nov;31(11):52-53
Joel Schwartzkopf practices at Colorado State University Health Network in Fort Collins, Colo. The author has disclosed no potential conflicts of interest, financial or otherwise.
Case Rep Crit Care 2018 25;2018:9756050. Epub 2018 Sep 25.
Caserta Hospital, Department of Anesthesia and Intensive Care, Italy.
The authors describe the case of a young woman who developed a clinical pictures resembling a septic shock-related multiple organ dysfunction syndrome a couple of months after having been diagnosed suffering from a hemophagocytic lymphohistiocytosis associated with an infectious mononucleosis. Despite the aggressive treatment, which included antibiotics, vasopressors, IV immunoglobulins, and the use of an extracorporeal device aimed to remove mediators released both during sepsis and the cytokine storm determined by the hemophagocytic lymphohistiocytosis, the patient died. At the autopsy, an extremely uncommon aggressive lymphoma of Epstein-Barr virus-positive T-lymphocytes with systemic involvement was discovered. Read More
Turk Arch Otorhinolaryngol 2018 Sep 1;56(3):183-184. Epub 2018 Sep 1.
Medical Student, Athens University, Athens, Greece.
Proteomics Clin Appl 2018 Oct 11:e1800067. Epub 2018 Oct 11.
Department of Pathology, Anhui Medical University, Hefei, 230032, China.
Purpose: Epstein-Barr virus (EBV) is a ubiquitous human gamma herpes virus that infects human epithelial cells and B lymphocytes. It would be potentially valuable to develop novel combined assays to benefit screening for large panels of samples of EBV infectious diseases.
Experimental Design: A simple antigen-probed biochip that is modified with S-S-PEG-COOH and is used as a label-free high-throughput screening method for a combined detection of EBV capsid antigen IgM antibody, capsid antigen IgG antibody, and nuclear antigen IgG antibody. Read More
Rev Med Suisse 2018 Oct;14(622):1799-1802
Service des maladies infectieuses, Institut Central des Hôpitaux, Hôpital du Valais, Avenue du Grand-Champsec 86, 1950 Sion.
Most cases of infectious mononucleosis are caused by Epstein-Barr virus (EBV). However, other rare but potentially serious etiologies need to be considered. Cytomegalovirus (CMV) and Toxoplasma gondii infections, although generally benign, can cause severe congenital infections. Read More
Minerva Pediatr 2018 10;70(5):425-429
IRVINE3 Labs, Department of Medical and Oral Sciences, and Biotechnologies, G. D'Annunzio University, Chieti-Pescara, Italy.
Background: Infectious mononucleosis (IM) is a common disease of adolescents and young adults, characterized by a specific triad of symptoms represented by fever, sore throat and lymphadenopathy. IM may also affect older adults, with different, more intense signs and symptoms such as fatigue, general malaise, and diffuse body pain. The aim of this four-week-registry study was to evaluate the effects of Robuvit® supplementation on the main consequences of mononucleosis, particularly fatigue, in otherwise healthy adults. Read More
Clin Chem Lab Med 2018 Sep 29. Epub 2018 Sep 29.
Department of Clinical Laboratory, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
Background Epstein-Barr virus (EBV) DNA load monitoring in blood is essential for the diagnosis of EBV-associated diseases. However, the best-suited blood compartment for detection is still under discussion. The aim of this study was to evaluate the diagnostic value of EBV-DNA load in peripheral blood mononuclear cells (PBMC), plasma and whole blood (WB) samples. Read More
Brain Behav Immun 2019 Jan 25;75:94-100. Epub 2018 Sep 25.
Institute of Clinical Medicine, University of Oslo, Norway; Dept. of Pediatrics, Akershus University Hospital, Norway. Electronic address:
Introduction: Acute Epstein-Barr virus (EBV) infection is a trigger of chronic fatigue and Chronic Fatigue Syndrome (CFS). This study investigated baseline predictors of chronic fatigue six months after an acute EBV infection.
Materials And Methods: A total of 200 adolescents (12-20 years old) with acute EBV infection were assessed for 149 possible baseline predictors and followed prospectively. Read More
PLoS Pathog 2018 Sep 24;14(9):e1007110. Epub 2018 Sep 24.
Institute for Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
Human herpesviruses are antigenically rich agents that induce strong CD8+T cell responses in primary infection yet persist for life, continually challenging T cell memory through recurrent lytic replication and potentially influencing the spectrum of antigen-specific responses. Here we describe the first lytic proteome-wide analysis of CD8+ T cell responses to a gamma1-herpesvirus, Epstein-Barr virus (EBV), and the first such proteome-wide analysis of primary versus memory CD8+ T cell responses to any human herpesvirus. Primary effector preparations were generated directly from activated CD8+ T cells in the blood of infectious mononucleosis (IM) patients by in vitro mitogenic expansion. Read More
Medicine (Baltimore) 2018 Sep;97(38):e12380
Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam.
Primary Epstein-Barr virus (EBV) infection is common in childhood, and dual positivity of serum EBV IgM and cytomegalovirus (CMV) IgM antibodies occur in some cases. This study aimed to evaluate the cause of EBV and CMV IgM dual positivity to determine whether it represents a false-positive finding or a true coinfection.A total of 494 children diagnosed with primary EBV infection, manifesting as infectious mononucleosis, were recruited. Read More
Intern Med 2018 Sep 12. Epub 2018 Sep 12.
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
Chronic active Epstein-Barr virus (CAEBV) T-cell type infection, systemic form, is characterized by persistent infectious mononucleosis-like symptoms, high EBV DNA levels in the peripheral blood, organ damage, and a poor prognosis. The association between CAEBV and rheumatoid arthritis (RA) is unclear. We report a case of fatal CAEBV T-cell type infection in an RA patient undergoing treatment with cytotoxic T-lymphocyte-associated antigen 4 immunoglobulin fusion protein (abatacept, ABT). Read More
Med Microbiol Immunol 2018 Sep 10. Epub 2018 Sep 10.
Virology Department, Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Dr Subotica, Belgrade, 11000, Serbia.
Epstein-Barr virus (EBV) has been identified as a group 1 carcinogenic agent, particularly for nasopharyngeal carcinoma (NPC). The sequence diversity of EBV nuclear antigen 1 (EBNA1) reflects region-restricted polymorphisms, which may be associated with the development of certain malignancies. The aims of the present study were to evaluate EBV EBNA1 gene polymorphisms circulating in NPC, infectious mononucleosis, and isolates from patients with transplanted organs to determine if EBNA1 sequence specificities are useful as viral biomarkers for NPC. Read More
IDCases 2018 30;14:e00445. Epub 2018 Aug 30.
Infectious Disease Department, Centro Hospitalar do Porto, Portugal.
Introduction: Cytomegalovirus (CMV) infection in healthy adults is usually asymptomatic or causes a mild mononucleosis syndrome, while severe infections are rare in immunocompetent patients and poorly documented. When described, gastrointestinal tract and the central nervous systems are the most frequent sites of severe CMV infection. Lung disease can occur, but it's rare. Read More
Exp Ther Med 2018 Sep 6;16(3):2060-2065. Epub 2018 Jul 6.
Department of Hematology and Oncology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, P.R. China.
Angioimmunoblastic T cell lymphoma (AITL)-associated hemophagocytic lymphohistiocytosis (HLH) rarely occurs with annular erythema multiforme-like rashes. The present case report describes a patient who was misdiagnosed with erythema multiforme at an early stage of the disease due to annular erythema multiforme-like eruptions. However, antihistamine treatment was ineffective. Read More
Clin Med Res 2018 Aug 30. Epub 2018 Aug 30.
Integrated Research and Development Laboratory, Marshfield Clinic Research Institute, Marshfield, WI, USA
Lyme disease and infectious mononucleosis are common illnesses that share similar clinical presentations. Significant cross-reactivity is known to occur between Lyme and EBV serologic assays complicating the diagnosis. To date, no prior cases of concurrent acute Lyme and EBV infections have been reported. Read More
BMJ Case Rep 2018 Aug 29;2018. Epub 2018 Aug 29.
Department of Neurology, Tergooi, Blaricum, The Netherlands.
Neurological manifestations of a primary Epstein-Barr virus (EBV) infection are rare. We describe a case with acute transverse myelitis and another case with a combination of polyradiculitis and anterior horn syndrome as manifestations of a primary EBV infection.The first case is a 50-year-old immunocompetent male diagnosed with acute transverse myelitis, 2 weeks after he was clinically diagnosed with infectious mononucleosis. Read More
Prostate 2018 Sep 30;78(13):1024-1034. Epub 2018 May 30.
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
Background: To extend our previous observation of a short-term rise in prostate-specific antigen (PSA) concentration, a marker of prostate inflammation and cell damage, during and immediately following sexually transmitted and systemic infections, we examined the longer-term influence of these infections, both individually and cumulatively, on PSA over a mean of 10 years of follow-up in young active duty U.S. servicemen. Read More
Cureus 2018 Jun 14;10(6):e2808. Epub 2018 Jun 14.
Internal Medicine, Palisades Medical Center, New Jersey, USA.
An Epstein-Barr Virus (EBV) infection generally presents with the classic infectious mononucleosis symptomatology-sore throat, lymph node enlargement, and fatigue. However, there are cases in which induced hepatitis does occur. The liver enzymes leaked during the acute damage would be apparent in the serum as an elevation of transaminases and alkaline phosphatase. Read More
Sci Rep 2018 Aug 15;8(1):12204. Epub 2018 Aug 15.
Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, United States of America.
Metabolites detectible in human biofluids are attractive biomarkers for the diagnosis of early Lyme disease (ELD), a vector-borne infectious disease. Urine represents an easily obtained clinical sample that can be applied for diagnostic purposes. However, few studies have explored urine for biomarkers of ELD. Read More
J Virol 2018 Nov 29;92(22). Epub 2018 Oct 29.
Section of Virology, Faculty of Medicine, Norfolk Place, London, United Kingdom
One hundred thirty-eight new Epstein-Barr virus (EBV) genome sequences have been determined. One hundred twenty-five of these and 116 from previous reports were combined to produce a multiple-sequence alignment of 241 EBV genomes, which we have used to analyze variation within the viral genome. The type 1/type 2 classification of EBV remains the major form of variation and is defined mostly by EBNA2 and EBNA3, but the type 2 single-nucleotide polymorphisms (SNPs) at the EBNA3 locus extend into the adjacent gp350 and gp42 genes, whose products mediate infection of B cells by EBV. Read More
Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Aug;26(4):1210-1214
Department of Laboratorial Medicine，Wuhan Central Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology，Wuhan 430016, Hubei Province, China. E-mail:
Objective: To investigate the diagnostic value of combined detection of HLA-G and IL-6 in children with infectious mononucleosis (IM).
Methods: Eighty-three children suffered from infectious mononucleosis hospitalized in Wuhan Children's Hospital（Wuhan Maternal and Child Healthcare Hospital） from January 2014 to June 2017 were selected as the IM group, 83 healthy children in the same period were selected as the as control group. Enzyme-linked in munosorbent assay (ELISA) was used to detect and compare the changes of HLA-G and IL-6 levels between 2 groups. Read More
J Surg Case Rep 2018 Aug 7;2018(8):rjy203. Epub 2018 Aug 7.
Department of Cardiothoracic Surgery, Northern General Hospital, Herries Road, Sheffield, UK.
Descending mediastinitis is a rare, life-threatening condition caused by contiguous spread of oropharyngeal or cervical infection into the mediastinum. Infectious mononucleosis generally results in a self-limited illness characterized by fever, pharyngitis and lymphadenopathy. We present an exceptional case of an 18-year-old with infectious mononucleosis complicated by progressive bacterial superinfection and fulminant descending mediastinitis. Read More
Mult Scler 2018 Aug 7:1352458518793524. Epub 2018 Aug 7.
National Centre for Epidemiology & Population Health, Research School of Population Health, The Australian National University, Canberra, ACT, Australia/Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, WA, Australia.
Background: The evidence associating diet and risk of multiple sclerosis is inconclusive.
Objective: We investigated associations between dietary patterns and risk of a first clinical diagnosis of central nervous system demyelination, a common precursor to multiple sclerosis.
Methods: We used data from the 2003-2006 Ausimmune Study, a case-control study examining environmental risk factors for a first clinical diagnosis of central nervous system demyelination, with participants matched on age, sex and study region. Read More
Zhongguo Dang Dai Er Ke Za Zhi 2018 Jul;20(7):563-566
Department of Pediatrics, Ningbo Women and Children's Hospital, Ningbo, Zhejiang 315000, China.
Objective: To study the clinical effect of pidotimod oral liquid as adjuvant therapy for infectious mononucleosis and its effect on T lymphocyte subsets.
Methods: A total of 76 children with infectious mononucleosis, who were admitted to the hospital between July 2016 and June 2017, were enrolled and randomly divided into two groups: conventional treatment and pidotimod treatment (n=38 each). The children in the conventional treatment group were given antiviral therapy with ganciclovir for injection and symptomatic treatment. Read More
Neth J Med 2018 Jul;76(5):251-254
Department of Internal Medicine, Northwest Clinics, Alkmaar, the Netherlands.
Cytomegalovirus (CMV) infections are often asymptomatic, but symptoms can range from a mononucleosis-like syndrome to a severe, disseminated infection in immunocompromised patients. We present two cases of immunocompetent patients with acute CMV infection directly followed by portal vein thrombosis in one and pulmonary embolism in the other patient. Thromboembolism may be a severe complication of acute CMV infection, with possible therapeutic implications. Read More
J Allergy Clin Immunol Pract 2018 Aug 15. Epub 2018 Aug 15.
Department of Experimental and Clinical Medicine, Internal Medicine Unit, University of Florence, Florence, Italy.
Am J Clin Pathol 2018 Aug;150(4):310-317
Pathology Service, Fundación Jiménez Díaz, CIBERONC, Madrid, Spain.
Objectives: Spontaneous rupture of the spleen is occasionally seen as the presenting event in infectious mononucleosis (IM). Diagnosis of these cases can be very challenging.
Methods: We describe the morphologic and immunohistochemical findings in a series of seven splenectomy specimens removed after spontaneous rupture in patients with IM. Read More
BMJ Case Rep 2018 Jul 6;2018. Epub 2018 Jul 6.
Internal Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
A 28-year-old man presented to our clinic over the course of 3 weeks with symptoms that progressed from mild headaches to fever, fatigue, myalgia and an enlarged right preauricular lymph node with ipsilateral conjunctivitis and upper eyelid weakness. Our differential included Epstein Barr Virus/Cytomegalovirus mononucleosis, bacterial conjunctivitis and lymphoma. We evaluated with CBC, EBV IgM Ab, lactate dehydrogenase level and a CMV IgG Ab which were all within normal limits. Read More
Front Oncol 2018 13;8:211. Epub 2018 Jun 13.
Biomedical Research Center, Qatar University, Doha, Qatar.
The Epstein-Barr virus (EBV) is a DNA lymphotropic herpesvirus and the causative agent of infectious mononucleosis. EBV is highly prevalent since it affects more than 90% of individuals worldwide and has been linked to several malignancies including PTLDs, which are one of the most common malignancies following transplantation. Among all the EBV genes, most of the recent investigations focused on studying the LMP-1 oncogene because of its high degree of polymorphism and association with tumorigenic activity. Read More
Front Neurol 2018 8;9:418. Epub 2018 Jun 8.
Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.
Age at symptom onset (ASO) is a prognostic factor that could affect the accrual of disability in multiple sclerosis (MS) patients. Some factors are known to influence the risk of multiple sclerosis (MS), but their influence on the ASO is less well-investigated. Examine the associations between known or emerging MS risk factors and ASO. Read More
Cureus 2018 Apr 19;10(4):e2505. Epub 2018 Apr 19.
Department of General and Visceral Surgery, Katholisches Klinikum Bochum - St. Josef Hospital, Ruhr University Bochum.
Infectious mononucleosis is a common disease of the adolescent caused by the Epstein-Barr virus (EBV). We present a rare case of a male adult with acalculous cholecystitis due to infectious mononucleosis. A correct diagnosis was challenging due to a false negative antibody test. Read More
Georgian Med News 2018 May(278):132-138
Kharkiv National Medical University, Department of Children's Infectious Diseases; V.N. Karasin Kharkov National University, Department of Pediatrics №2; Department of Clinical Immunology and Allergy, Ukraine.
The article presents the results of our own studies to determine the criteria for the adverse variants of the course of infectious mononucleosis (IM) in children. The study was conducted in the regional children's infectious clinical hospital in Kharkov. 161 children aged three to fifteen years were under observation with diagnosis of infectious moninucleosis. Read More
Cancers (Basel) 2018 Jun 13;10(6). Epub 2018 Jun 13.
Department of Microbiology and Immunology, University of Leuven, BE-3000 Leuven, Belgium.
Epstein⁻Barr virus (EBV) infects up to 95% of the adult human population, with primary infection typically occurring during childhood and usually asymptomatic. However, EBV can cause infectious mononucleosis in approximately 35⁻50% cases when infection occurs during adolescence and early adulthood. Epstein⁻Barr virus is also associated with several B-cell malignancies including Burkitt lymphoma, Hodgkin lymphoma, and post-transplant lymphoproliferative disease. Read More
Adv Exp Med Biol 2018 ;1045:477-493
Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and is associated with several malignancies, including nasopharyngeal carcinoma, gastric carcinoma, Hodgkin lymphoma, Burkitt lymphoma, and lymphomas in immunocompromised persons, as well as multiple sclerosis. A vaccine is currently unavailable. While monomeric EBV gp350 was shown in a phase 2 trial to reduce the incidence of infectious mononucleosis, but not the rate of EBV infection, newer formulations of gp350 including multimeric forms, viruslike particles, and nanoparticles may be more effective. Read More
Adv Exp Med Biol 2018 ;1045:395-412
Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
In addition to latent genes, lytic genes of EBV must also be of extreme significance since propagation of the virus can be achieved only through execution of lytic cycle. Research on EBV lytic genes may thus prevent spreading of the virus and alleviate disorders, such as infectious mononucleosis and oral hairy leukoplakia, which are highly associated with EBV lytic infection. Moreover, recent advancements have been demonstrating that at least several lytic genes are expressed to some extent even during latent state. Read More
MMW Fortschr Med 2018 May;160(10):44-48
Sektion Klinische Infektiologie, Med. Klinik und Poliklinik IV, Klinikum der Universität München, Pettenkoferstr. 8a, D-80336, München, Deutschland.
Kans J Med 2018 Feb 28;11(1):1-12. Epub 2018 Feb 28.
Infectious Disease Associates of Kansas City, Kansas City, MO.