9,352 results match your criteria Mononucleosis

Two cases of EBV infection preceding lymphoma.

J Cancer Res Clin Oncol 2022 Jun 22. Epub 2022 Jun 22.

Medical Clinic III for Oncology, Hematology, Immune-Oncology and Rheumatology, University Medical Center Bonn (UKB), Venusberg-Campus 1, 53127, Bonn, Germany.

Infection of lymphocytes with the Epstein-Barr virus (EBV) is a well-documented risk factor for developing lymphoma. The incidence of EBV positivity in lymphoma depends on the subtype and can range from 10% in diffuse large B-cell lymphoma (DLBCL) to 100% in endemic Burkitt lymphoma (BL), (Shannon-Lowe and Rickinson, Front Oncol 9:713, 2019). However, in most cases, EBV infection remains unnoticed until diagnosis of lymphoma is made. Read More

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Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge.

Cell Rep Med 2022 Jun 14;3(6):100658. Epub 2022 Jun 14.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA; Department of Global Health, University of Washington, Seattle, WA 98195, USA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle WA 98115, USA. Electronic address:

Epstein-Barr virus (EBV) is a cancer-associated pathogen responsible for 165,000 deaths annually. EBV is also the etiological agent of infectious mononucleosis and is linked to multiple sclerosis and rheumatoid arthritis. Thus, an EBV vaccine would have a significant global health impact. Read More

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Epstein-Barr Virus Reactivation Causing Cholestatic Hepatitis.

Cureus 2022 Apr 28;14(4):e24552. Epub 2022 Apr 28.

Gastroenterology and Hepatology, University of Connecticut Health, Farmington, USA.

Infection with Epstein-Barr virus (EBV) is common and associated with a high seroprevalence. It is often asymptomatic, but infectious mononucleosis (IM) is the clinical hallmark of this disease especially among teens. Hepatic involvement during primary EBV infection often results in mild self-resolving elevation of liver enzymes, typically in association with IM. Read More

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Recurrence of infectious mononucleosis in adults after remission for 3 years: A case report.

World J Clin Cases 2022 Apr;10(12):3951-3958

Department of Hematology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang Province, China.

Background: Infectious mononucleosis (IM) is a disease caused by Epstein-Barr virus (EBV). EBV infection is common in children; however, it can cause IM in adults. Studies on recurrence of IM in adults after remission are limited. Read More

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Pre-illness data reveals differences in multiple metabolites and metabolic pathways in those who do and do not recover from infectious mononucleosis.

Mol Omics 2022 May 31. Epub 2022 May 31.

Northwestern University Feinberg School of Medicine, Department of Pediatrics and Lurie Children's Hospital, Chicago, Illinois, USA.

Metabolic pathways related to energy production, amino acids, nucleotides, nitrogen, lipids, and neurotransmitters in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may contribute to the pathophysiology of ME/CFS. 4501 Northwestern University college students were enrolled in a prospective, longitudinal study. We collected data before illness, during infectious mononucleosis (IM), and at a 6 month follow-up for those who recovered ( = 18) those who went on to develop ME/CFS 6 months later ( = 18). Read More

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[Fatigue Doesn't Always have to be caused by SARS-CoV-2: Case Report].

Padiatr Padol 2022 May 19:1-4. Epub 2022 May 19.

Kindermedizinisches Zentrum Augarten (kiz augarten) Ges.m.b.H., Pazmanitengasse 12/EG, A-1020 Wien, Österreich.

We report on a 17-year-old female adolescent who presented with marked fatigue. The cause of this was found to be Epstein-Barr virus (EBV) infection. Even during the COVID-19 pandemic, fatigue doesn't always have to be caused by SARS-CoV‑2 but can also be induced by other adolescent-onset diseases (EBV), Up to 13. Read More

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Chronic Active Epstein-Barr Virus Infection Indistinguishable from Autoimmune Hepatitis: A Case Report.

Yonago Acta Med 2022 May 13;65(2):160-165. Epub 2022 Apr 13.

Division of Medicine and Clinical Science, Department of Gastroenterology and Nephrology, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan.

Chronic active Epstein-Barr virus (CAEBV) infection is a rare disease, mainly affecting children, typically characterized by persistent infectious mononucleosis (IM)-like symptoms. We describe an adult case of CAEBV without IM-like symptoms, which was indistinguishable from autoimmune hepatitis (AIH). A 60-year-old woman with liver damage was diagnosed with AIH (International Diagnostic Score: 16 points). Read More

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A Malignant Mimicker: Features of Kikuchi-Fujimoto Disease in the Pediatric Population.

Pediatr Dev Pathol 2022 May 18:10935266221103882. Epub 2022 May 18.

Department of Laboratory Medicine and Pathology, 7284University of Washington, Seattle, WA, USA.

Background: Kikuchi-Fujimoto disease (KFD) is a rare, benign, and self-limited disease that presents with cervical lymphadenopathy and systemic symptoms. Histologic evaluation is often necessary to differentiate KFD from other entities.

Methods: Electronic medical records and diagnostic material were reviewed for 14 children diagnosed with KFD and 6 children diagnosed with infectious mononucleosis (IM) from 2013-2021. Read More

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Skin rash following amoxicillin treatment.

Eur J Intern Med 2022 May 13. Epub 2022 May 13.

Department of General Medicine, National Defense Medical College, Saitama, Japan. Electronic address:

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A novel high throughput assay to quantify Epstein-Barr virus neutralizing antibody activity against B-cell and epithelial cell infections for vaccine and therapeutic developments.

Vaccine 2022 Jun 14;40(26):3638-3646. Epub 2022 May 14.

Infectious Disease and Vaccines, Merck & Co., Inc., Kenilworth, NJ 07033 USA.

Epstein-Barr Virus (EBV) is the causative agent of infectious mononucleosis and has been associated with a variety of malignancies. In vivo, EBV infects B cells and epithelial cells. However, the current EBV neutralization assays, especially those against B cell infection, are low throughput, laborious and lack of sensitivity. Read More

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[Virus-induced exanthems in returning travellers].

Hautarzt 2022 Jun 13;73(6):462-474. Epub 2022 May 13.

Medizinische Fakultät und Uniklinik Köln, Klinik für Dermatologie und Venerologie, Universität zu Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

Dermatological diseases are among the most common travel-associated diseases. In particular, viral infections not only with tropical and subtropical pathogens, but also with viruses common in Germany, which are often accompanied by skin rashes and general symptoms, are of great importance. In addition to an accurate travel history and possible risk exposures, epidemiological information on country-specific risks in combination with molecular and serological analyses is helpful in making the correct diagnosis. Read More

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Acute Acalculous Cholecystitis due to EBV Infection Presenting as Acute Abdomen.

Gulhadiye Avcu

J Coll Physicians Surg Pak 2022 May;32(5):662-664

Department of Pediatrics, Division of Pediatric Infectious Diseases, Balikesir Ataturk City Hospital, Balikesir, Turkey.

Epstein-Barr Virus (EBV) is a herpes virus with a high seropositivity rate among the adult population throughout the world. Primary EBV infection is usually asymptomatic among young children. As age increases, it begins to manifest as infectious mononucleosis. Read More

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Acute Horner syndrome secondary to glandular fever due to Epstein Barr virus infection.

Arch Soc Esp Oftalmol (Engl Ed) 2022 May 11;97(5):281-285. Epub 2022 Mar 11.

Departamento de Oftalmología, Hospital Clínico Universitario de Valencia, Valencia, Spain; Departamento de Oftalmología, Facultad de Medicina, Universidad de Valencia, Valencia, Spain.

We present a clinical situation where a 47-year old female patient consulted with left partial ptosis and miosis that started, two weeks before, with an episode of glandular fever secondary to Epstein-Barr infection. Apraclonidine 0.5% and Phenylephrine 1% drop testing was performed with results consistent with suspected left Horner Syndrome (HS), with a probable postganglionic location. Read More

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A bivalent Epstein-Barr virus vaccine induces neutralizing antibodies that block infection and confer immunity in humanized mice.

Sci Transl Med 2022 05 4;14(643):eabf3685. Epub 2022 May 4.

Sanofi, 640 Memorial Dr., Cambridge, MA 02139, USA.

Epstein-Barr virus (EBV) is the major cause of infectious mononucleosis and is associated with several human cancers and, more recently, multiple sclerosis. Despite its prevalence and health impact, there are currently no vaccines or treatments. Four viral glycoproteins (gp), gp350 and gH/gL/gp42, mediate entry into the major sites of viral replication, B cells, and epithelial cells. Read More

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Four Decades of Prophylactic EBV Vaccine Research: A Systematic Review and Historical Perspective.

Front Immunol 2022 14;13:867918. Epub 2022 Apr 14.

Department of Immuno-Oncology, Beckman Research Institute of City of Hope, Duarte, CA, United States.

Background: Epstein-Barr virus (EBV) is the causal agent of infectious mononucleosis and has been associated with various cancers and autoimmune diseases. Despite decades of research efforts to combat this major global health burden, there is no approved prophylactic vaccine against EBV. To facilitate the rational design and assessment of an effective vaccine, we systematically reviewed pre-clinical and clinical prophylactic EBV vaccine studies to determine the antigens, delivery platforms, and animal models used in these studies. Read More

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Acute Cytomegalovirus Infection Associated With Splenic Infarction: A Case Report and Review of the Literature.

Cureus 2022 Mar 22;14(3):e23404. Epub 2022 Mar 22.

General and Colorectal Surgery, University of New South Wales, St. Vincent's Hospital, Sydney, AUS.

Splenic infarction associated with acute cytomegalovirus infection (CMV) in immunocompetent patients was initially described as a very rare occurrence but has been reported in recent years with increasing frequency. Many cases undergo multiple investigations only to leave acute CMV as the likely cause. There is a risk of splenic rupture and, although this complication is rare, fatalities have occurred. Read More

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Infectious mononucleosis - should we routinely assess liver function in acute presentation and follow up?

J Laryngol Otol 2022 Apr 25:1-13. Epub 2022 Apr 25.

Department of Oncology & Metabolism, University of Sheffield.

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Case Report: Chronic Active Epstein-Barr Virus Infection With Subcutaneous Nodules and Systemic Damage.

Front Med (Lausanne) 2022 31;9:759834. Epub 2022 Mar 31.

Department of Infectious Diseases, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Chronic active Epstein-Barr virus (CAEBV) infection is a rare and progressive systemic lymphoproliferative disorder often beginning as an infectious mononucleosis (IM)-like illness. It manifests with fever, splenomegaly, hepatitis, lymphadenopathy, and occasionally cytopenias, pneumonitis, and vasculitis. We report a 23-year-old woman with fever and subcutaneous nodules first appearing on the limbs and then spreading to the body. Read More

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Splenic infarction after Epstein-Barr virus infection in a patient with hereditary spherocytosis: a case report and literature review.

BMC Surg 2022 Apr 9;22(1):136. Epub 2022 Apr 9.

Department of Hepatobiliary Surgery, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People's Republic of China.

Background: Hereditary spherocytosis (HS) complicated by splenic infarction is very rare, and it is even rarer to develop splenic infarction after infectious mononucleosis (IM) as a result of Epstein-Barr virus (EBV) infection. Therefore, misdiagnosis or missed diagnosis is prone to occur.

Case Presentation: A 19-year-old Chinese female previously diagnosed with HS was admitted to our institution with persistent high fever and icterus. Read More

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ZEA and DON inhibited inflammation after L. monocytogenes infection and induced ribosomal hyperfunction.

Ecotoxicol Environ Saf 2022 May 5;236:113470. Epub 2022 Apr 5.

College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu, China. Electronic address:

The complex microbial community in food environment is a major problem of human or animal health and safety. Mycotoxins and food-borne bacteria can both induce inflammation in the body and cause a series of changes in biological functions. In this study, mice were gavaged with low doses of ZEA, DON, or ZEA + DON, and then infected with L. Read More

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Infectious Mononucleosis Complicated With COVID-19.

Pediatr Infect Dis J 2022 07 7;41(7):e301. Epub 2022 Jun 7.

Department of Pediatrics, Chungbuk National University Hospital, Cheongju, South Korea.

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Predictors for Developing Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Following Infectious Mononucleosis.

J Rehabil Ther 2022 21;4(1):1-5. Epub 2022 Feb 21.

Northwestern University Feinberg School of Medicine, Department of Pediatrics, Chicago, 60611 USA.

Background: About 10% of individuals who contract infectious mononucleosis (IM) have symptoms 6 months later that meet criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our study for the first time examined whether it is possible to predict who will develop ME/CFS following IM.

Methods: We have reported on a prospectively recruited cohort of 4,501 college students, of which 238 (5. Read More

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February 2022

The association of infectious mononucleosis and invasive breast cancer in The Health of Women (HOW) Study.

Breast Cancer 2022 Jul 26;29(4):731-739. Epub 2022 Mar 26.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Background: The link between Epstein-Barr Virus (EBV) and breast cancer (BC) etiology remains unclear. We utilized the Health of Women (HOW) Study to understand the association between infectious mononucleosis (IM), a surrogate for EBV infection, and invasive BC.

Methods: The HOW Study was a web-based survey of BC risk factors with > 40, 000 participants; 183 had IM at < 10 years old, 3, 654 had IM between 10 and 22 years old, 764 had IM at > 22 years old, and 17, 026 never developed IM. Read More

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An Unusual Presentation of Glandular Fever.

Case Rep Infect Dis 2022 18;2022:5981070. Epub 2022 Mar 18.

Infectious Diseases, Morriston Hospital, Swansea, UK.

Epstein-Barr virus (EBV) is an ubiquitous DNA herpesvirus with >90% of adults >40 years of age showing a serological response. While in their youth, primary EBV infection may pass unnoticed, young adults have a high incidence of infectious mononucleosis (IM). This is characterized by a triad of pharyngitis, cervical lymphadenopathy, and fever because of a self-limiting lymphoproliferative disease. Read More

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Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans.

Brain 2022 Mar 7. Epub 2022 Mar 7.

Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.

Polygenic inheritance plays a pivotal role in driving multiple sclerosis susceptibility, an inflammatory demyelinating disease of the central nervous system. We developed polygenic risk scores (PRS) of multiple sclerosis and assessed associations with both disease status and severity in cohorts of European descent. The largest genome-wide association dataset for multiple sclerosis to date (n = 41,505) was leveraged to generate PRS scores, serving as an informative susceptibility marker, tested in two independent datasets, UK Biobank [UKBB, area under the curve (AUC) = 0. Read More

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Treatment-related fluctuations in Guillain-Barré syndrome​: clinical features and predictors of recurrence.

Arq Neuropsiquiatr 2022 Feb 21. Epub 2022 Feb 21.

Raul Carrea Institute for Neurological Research, Department of Neuromuscular, Buenos Aires, Argentina.

Background: A treatment-related fluctuation (TRF) in a patient with Guillain-Barré syndrome (GBS) is defined as clinical deterioration within two months of symptom onset following previous stabilization or improvements with treatment.

Objective: To investigate the clinical characteristics and factors that could increase the risk of relapse of GBS in patients with and without TRFs.

Methods: Retrospective review of medical records of patients (>18 years) with GBS evaluated between January/2006 and July/2019. Read More

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February 2022

Adenosine deaminase as a marker for the severity of infectious mononucleosis secondary to EBV in children.

BMC Infect Dis 2022 Feb 21;22(1):164. Epub 2022 Feb 21.

Pediatric intensive care unit, Children's Hospital of Soochow University, 303 Jingde Road, Suzhou, 215000, Jiangsu, China.

Background: Infectious mononucleosis, a common disease in children and young adults, is often accompanied by elevated transaminase levels and rarely, liver failure. This study aimed to determine whether adenosine deaminase is a marker of severity in children with infectious mononucleosis, especially those with elevated alanine transaminase levels.

Methods: This case-control study was conducted at the Children's Hospital of Soochow University. Read More

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February 2022

Relapsing Infectious Mononucleosis-Like Symptoms Associated with Liver Insufficiency in a Chronic Hepatitis B Patient with Common Variable Immunodeficiency.

Am J Case Rep 2022 Feb 20;23:e934003. Epub 2022 Feb 20.

Division of Gastroenterology, Department of Internal Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, Kanagawa, Japan.

BACKGROUND Common variable immunodeficiency (CVID) is a rare disease. Infectious mononucleosis-like symptoms due to Epstein-Barr virus reactivation in adulthood are also rare. Here, we aimed to report a case of Epstein-Barr virus reactivation presenting with relapsing infectious mononucleosis-like symptoms with liver failure in common variable immunodeficiency with chronic hepatitis B virus infection. Read More

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February 2022

Case Report: Pediatric Chronic Active Epstein-Barr Virus Infection With Giant Sinus of Valsalva Aneurysms and Aorta and Its Branch Dilations.

Front Pediatr 2021 31;9:779806. Epub 2022 Jan 31.

Department of Cardiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Chronic active Epstein-Barr virus infection (CAEBV), which often manifests as persistent infectious mononucleosis-like symptoms and can involve multiple organs, is a prolonged or reactivated status of primary EBV infection. Cardiovascular damage is one of the rare but severe complications correlated with poor prognosis among all CAEBV patients. Few published articles have demonstrated systemic arterial lesions involving branches of the aorta as cardiovascular complications. Read More

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January 2022

A Rare Case of Epstein-Barr Virus: Infectious Mononucleosis Complicated by Guillain-Barré Syndrome.

Cureus 2022 Jan 10;14(1):e21085. Epub 2022 Jan 10.

Internal Medicine, Northeast Georgia Medical Center Gainesville, Gainesville, USA.

Infectious mononucleosis (IM) is an acute disease caused by Epstein-Barr virus (EBV) infection affecting adolescents and young adults. Clinically, IM presents with fever, lymphadenopathy, and tonsillar pharyngitis. Guillain-Barré syndrome (GBS) has been reported as a possible rare complication of IM. Read More

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January 2022