8,928 results match your criteria Mononucleosis


Hunter syndrome with persistent thrombocytopenia.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Department of Pediatrics, APC, PGIMER, Chandigarh, India.

A case of Hunter syndrome, 6½-year-old boy presented with persistent thrombocytopenia and bleeding diathesis. However, cytopenia is not a usual presentation in patients with mucopolysaccharidosis II. After ruling out other causes of severe thrombocytopenia, a clinical possibility of chronic Epstein-Barr virus (EBV) infection was considered. Read More

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http://dx.doi.org/10.1136/bcr-2018-226518DOI Listing

[Lamotrigine induced hypersensitivity syndrome in children: a case report].

Authors:
N X Cui X P Zhu

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):356-358

Department of Neonatology, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.

Drug induced hypersensitivity syndrome (DIHS) is often manifested as severe systemic drug trans-reactions characterized by acute and extensive skin lesions (mostly measles-like rash), fever, enlargement of lymph nodes, multiple organ involvement (hepatitis, nephritis, and pneumonia), eosinophilia and mononucleosis,within 2-6 weeks of the application of sensitizing drugs. In the early stage of the lesion, macular papules or erythema multiforme were common, and in severe cases, exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis were also common. Most of them developed after taking allergic drugs for 2-6 weeks (average: 3 weeks). Read More

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April 2019
2 Reads

Prophylactic and therapeutic strategies for Epstein-Barr Virus-associated diseases: emerging strategies for clinical development.

Expert Rev Vaccines 2019 Apr 15. Epub 2019 Apr 15.

a QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Tumour Immunology Laboratory, Department of Immunology , QIMR Berghofer Medical Research Institute , Brisbane , Queensland , Australia.

Introduction: Epstein-Barr virus (EBV) infects more than 95% of the world's population and is associated with infectious mononucleosis as well as a number of cancers in various geographical locations. Despite its significant health burden, no licenced prophylactic or therapeutic vaccines are available. Areas covered: Over the last two decades, our understanding of the role of EBV infection in the pathogenesis and immune regulation of EBV-associated diseases has provided new lines of research to conceptualize various novel prophylactic and therapeutic approaches to control EBV-associated disease. Read More

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http://dx.doi.org/10.1080/14760584.2019.1605906DOI Listing

A Practical Review of Cytomegalovirus in Gastroenterology and Hepatology.

Gastroenterol Res Pract 2019 7;2019:6156581. Epub 2019 Mar 7.

Division of Gastroenterology and Hepatology, Scripps Clinic, La Jolla, CA, USA.

Human cytomegalovirus (CMV) is a ubiquitous virus with a wide spectrum of pathology in humans. Host immunity is a major determinant of the clinical manifestation of CMV and can vary widely in the gastroenterology and hepatology practice setting. Immunocompetent patients generally develop a benign, self-limited mononucleosis-like syndrome whereas gastrointestinal tissue-invasive disease is more frequently seen in immunocompromised and inflammatory bowel disease patients. Read More

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https://www.hindawi.com/journals/grp/2019/6156581/
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http://dx.doi.org/10.1155/2019/6156581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431500PMC
March 2019
2 Reads

The rash with maculopapules and fever in adults.

Clin Dermatol 2019 Mar - Apr;37(2):109-118. Epub 2018 Dec 5.

Dermatology Department, University of CT Health Center, Farmington, Connecticut, USA. Electronic address:

There is a broad differential diagnosis for the presentation of fever and maculopapular rash in an adult. Although some causative conditions are benign, others are medical emergencies that require prompt diagnosis. We describe various conditions that result in a fever and maculopapular rash in adults. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2018.12.004DOI Listing
December 2018
1 Read

Exceptional association of hypocomplementemic urticarial vasculitis syndrome (HUVS) and symptomatic pulmonary histoplasmosis: a case-based literature review.

Clin Rheumatol 2019 Apr 13. Epub 2019 Apr 13.

Departments of Medicine and Rheumatology, MetroHealth Medical Center, Cleveland, OH, USA.

Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare type III hypersensitivity disorder characterized by urticarial vasculitis and prolonged hypocomplementemia. Individuals with HUVS may also have joint involvement, pulmonary manifestations, ocular disease, kidney inflammation, or any other form of organ involvement. Hypocomplementemia, the presence of C1q antibody in the serum, and urticarial vasculitis are the keys to the diagnosis of HUVS. Read More

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http://dx.doi.org/10.1007/s10067-019-04548-8DOI Listing
April 2019
1 Read

Immunization with Components of the Viral Fusion Apparatus Elicits Antibodies That Neutralize Epstein-Barr Virus in B Cells and Epithelial Cells.

Immunity 2019 Apr 4. Epub 2019 Apr 4.

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with epithelial-cell cancers and B cell lymphomas. An effective EBV vaccine is not available. We found that antibodies to the EBV glycoprotein gH/gL complex were the principal components in human plasma that neutralized infection of epithelial cells and that antibodies to gH/gL and gp42 contributed to B cell neutralization. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.03.010DOI Listing
April 2019
1 Read

THE VALUE OF QUANTITY OF STREPTOCOCCI ON THE NASAL AND OROPHARYNGEAL MUCOSA ON THE FORMATION OF THE CELLULAR IMMUNITY IN CHILDREN WITH INFECTIOUS MONONUCLEOSIS.

Georgian Med News 2019 Feb(287):57-60

Kharkiv Medical Academy of Postgraduate Education, Ukraine.

The article presents the results of a comparative analysis of the cellular level of the immune response of children with mononucleosis in different periods of the disease of IM in children with different degrees of dissemination by streptococcus from their nasal and oropharyngeal mucosa. To achieve the goal, 60 children aged from three to seven years old with patients with infectious mononucleosis were examined, who were treated at the Regional Children's Infectious Clinical Hospital of Kharkiv, Ukraine. In 30 children (the first group), Streptococcus pyogenes was isolated in concentrations of 10-5 and higher during bacteriological examination of the nasal and oropharyngeal mucosa. Read More

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February 2019
3 Reads

[THE FEATURES OF THE COURSE OF INFECTIOUS MONONUKLEOSIS OF DIFFERENT ETIOLOGY IN CHILDREN].

Georgian Med News 2019 Feb(287):51-56

Odessa National Medical University, Ukraine.

Aim - to study the effect of different pathogens (EBV, CMV, HHV-6, and MIXT) on the severity of clinical-paraclinical manifestations of infectious mononucleosis in children. The clinical and laboratory study performed for 410 children aged from 10 months up to 12 years with infectious mononucleosis. The association of herpes viruses, mainly EBV, CMV and HHV type 6, takes part in the formation of the clinical picture of IM in (52,9%) of cases. Read More

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February 2019
3 Reads

EBV-requisitioning physicians' guess on fatigue state 6 months after acute EBV infection.

BMJ Paediatr Open 2019 1;3(1):e000390. Epub 2019 Mar 1.

Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway.

We assessed referring medical practitioner's ability to predict chronic fatigue development in adolescents presenting with acute infectious mononucleosis. Compared with being predicted as and were both strongly associated with developing fatigue 6 months later (OR 2.5, 95% CI 1. Read More

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http://dx.doi.org/10.1136/bmjpo-2018-000390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422241PMC
March 2019
1 Read

Plasmacytoid dendritic cells respond to Epstein-Barr virus infection with a distinct type I interferon subtype profile.

Blood Adv 2019 Apr;3(7):1129-1144

Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.

Infectious mononucleosis, caused by infection with the human gamma-herpesvirus Epstein-Barr virus (EBV), manifests with one of the strongest CD8 T-cell responses described in humans. The resulting T-cell memory response controls EBV infection asymptomatically in the vast majority of persistently infected individuals. Whether and how dendritic cells (DCs) contribute to the priming of this near-perfect immune control remains unclear. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018025536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457222PMC
April 2019
3 Reads

Initial Characterization of the Epstein⁻Barr Virus BSRF1 Gene Product.

Viruses 2019 Mar 21;11(3). Epub 2019 Mar 21.

Department of Virology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

Epstein⁻Barr virus (EBV) is a ubiquitous virus that causes infectious mononucleosis and several types of cancer, such as Burkitt lymphoma, T/NK-cell lymphoma, and nasopharyngeal carcinoma. As a herpesvirus, it encodes more than 80 genes, many of which have not been characterized. EBV HI S rightward reading frame 1 (BSRF1) encodes a tegument protein that, unlike its homologs herpes simplex virus unique long 51 (UL51) and human cytomegalovirus UL71, has not been extensively investigated. Read More

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https://www.mdpi.com/1999-4915/11/3/285
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http://dx.doi.org/10.3390/v11030285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466199PMC
March 2019
7 Reads

Apoptotic lymphocytes on peripheral smear and positional parameter values (VCS data) can suggest a diagnosis of infectious mononucleosis.

Infect Dis (Lond) 2019 Mar 19:1-4. Epub 2019 Mar 19.

a Department of Pathology and Laboratory Medicine , Columbia Asia Referral Hospital - Yeshwanthpur , Bangalore , Karnataka , India.

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http://dx.doi.org/10.1080/23744235.2019.1588473DOI Listing
March 2019
1 Read

Novel Therapeutics for Epstein⁻Barr Virus.

Molecules 2019 Mar 12;24(5). Epub 2019 Mar 12.

Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.

Epstein⁻Barr virus (EBV) is a human γ-herpesvirus that infects up to 95% of the adult population. Primary EBV infection usually occurs during childhood and is generally asymptomatic, though the virus can cause infectious mononucleosis in 35⁻50% of the cases when infection occurs later in life. EBV infects mainly B-cells and epithelial cells, establishing latency in resting memory B-cells and possibly also in epithelial cells. Read More

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https://www.mdpi.com/1420-3049/24/5/997
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http://dx.doi.org/10.3390/molecules24050997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429425PMC
March 2019
5 Reads

Screening for Epstein-Barr virus (EBV) infection status in university freshmen: acceptability of a gingival swab method.

Epidemiol Infect 2019 Jan;147:e140

Department of Laboratory Medicine and Pathology,University of Minnesota Medical School,Minneapolis, MN 55455,USA.

Prophylactic vaccines against Epstein-Barr virus (EBV) are under development. EBV-naïve college freshmen are ideal candidates for an efficacy trial, because their incidence of infectious mononucleosis (mono) during freshman year is as high as 20%. To assess perceptions about mono and a mono vaccine, and to learn if EBV immune status could be determined using a gingival swab rather than phlebotomy, we performed a cross-sectional study of 235 healthy students at the beginning of their freshman year. Read More

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http://dx.doi.org/10.1017/S0950268819000335DOI Listing
January 2019
1 Read

Progress in EBV Vaccines.

Front Oncol 2019 25;9:104. Epub 2019 Feb 25.

German Cancer Research Center (DKFZ), Heidelberg, Germany.

The Epstein-Barr virus (EBV) is a ubiquitous pathogen that imparts a significant burden of disease on the human population. EBV is the primary cause of infectious mononucleosis and is etiologically linked to the development of numerous malignancies. In recent years, evidence has also been amassed that strongly implicate EBV in the development of several autoimmune diseases, including multiple sclerosis. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00104/
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http://dx.doi.org/10.3389/fonc.2019.00104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398348PMC
February 2019
5 Reads

The BOLF1 gene is necessary for effective Epstein-Barr viral infectivity.

Virology 2019 Feb 23;531:114-125. Epub 2019 Feb 23.

Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Japan. Electronic address:

The Epstein-Barr virus (EBV) is a causative agent of infectious mononucleosis and several malignancies. Here, we focused on an EBV lytic protein, BOLF1, which is conserved throughout the herpesvirus family and is reported to be a virion tegument protein. We first constructed BOLF1-deficient viruses using the bacterial artificial chromosome (BAC) and CRISPR/Cas9 systems. Read More

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http://dx.doi.org/10.1016/j.virol.2019.02.015DOI Listing
February 2019
1 Read

A Validated Scale for Assessing the Severity of Acute Infectious Mononucleosis.

J Pediatr 2019 Mar 7. Epub 2019 Mar 7.

Center for Community Research, DePaul University, Chicago, IL.

Objectives: To develop a scale for the severity of mononucleosis.

Study Design: One to 5 percent of college students develop infectious mononucleosis annually, and about 10% meet criteria for chronic fatigue syndrome (CFS) 6 months following infectious mononucleosis. We developed a severity of mononucleosis scale based on a review of the literature. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223476193012
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http://dx.doi.org/10.1016/j.jpeds.2019.01.035DOI Listing
March 2019
6 Reads

Revisiting the Tissue Microenvironment of Infectious Mononucleosis: Identification of EBV Infection in T Cells and Deep Characterization of Immune Profiles.

Front Immunol 2019 20;10:146. Epub 2019 Feb 20.

Institute for Pathology, Unfallkrankenhaus Berlin, Berlin, Germany.

To aid understanding of primary EBV infection, we have performed an in depth analysis of EBV-infected cells and of local immune cells in tonsils from infectious mononucleosis (IM) patients. We show that EBV is present in approximately 50% of B-cells showing heterogeneous patterns of latent viral gene expression probably reflecting different stages of infection. While the vast majority of EBV+ cells are B-cells, around 9% express T-cell antigens, with a predominance of CD8+ over CD4+ cells. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391352PMC
February 2019
1 Read

Higher Non-processed Red Meat Consumption Is Associated With a Reduced Risk of Central Nervous System Demyelination.

Front Neurol 2019 19;10:125. Epub 2019 Feb 19.

School of Public Health, Curtin University, Perth, WA, Australia.

The evidence associating red meat consumption and risk of multiple sclerosis is inconclusive. We tested associations between red meat consumption and risk of a first clinical diagnosis of central nervous system demyelination (FCD), often presaging a diagnosis of multiple sclerosis. We used food frequency questionnaire data from the 2003-2006 Ausimmune Study, an incident, matched, case-control study examining environmental risk factors for FCD. Read More

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http://dx.doi.org/10.3389/fneur.2019.00125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389668PMC
February 2019
1 Read

Cervical necrotising fasciitis: a rare complication of infectious mononucleosis.

BMJ Case Rep 2019 Mar 1;12(3). Epub 2019 Mar 1.

Otolaryngology Head and Neck Surgery, Saint Barnabas Medical Center, Livingston, New Jersey, USA.

Cervical necrotising fasciitis (NF) is an aggressive polymicrobial infection of the subcutaneous tissues in the head and neck. We present a case of a healthy 19-year-old man who developed cervical and upper mediastinal NF after an initial presentation of infectious mononucleosis (IM). He was treated with broad-spectrum antibiotics in addition to incision and drainage of an anterior neck and upper mediastinal abscess. Read More

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http://dx.doi.org/10.1136/bcr-2018-228172DOI Listing
March 2019
1 Read

Epstein-Barr virus latent gene EBNA-1 genetic diversity among transplant patients compared with patients with infectious mononucleosis.

Clin Transplant 2019 Apr 1;33(4):e13504. Epub 2019 Apr 1.

Division of Infectious Diseases, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Introduction: As a step toward evaluating the association between Epstein-Barr virus genetic diversity and post-transplant lymphoproliferative disorder (PTLD), we conducted a preliminary study to compare the genetic diversity of the EBNA-1 gene among transplant patients and patients with infectious mononucleosis (IM).

Methods: We sequenced the EBNA-1 gene in blood samples from study subjects using Sanger methodology. The sequences were aligned with a reference strain and compared with publicly available sequences. Read More

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http://dx.doi.org/10.1111/ctr.13504DOI Listing

Epstein-Barr Virus-Associated γδ T-Cell Lymphoproliferative Disorder Associated With Hypomorphic Mutation.

Front Pediatr 2019 4;7:15. Epub 2019 Feb 4.

Department of Child Health and Development, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Chronic active Epstein-Barr virus (EBV) infection (CAEBV) is an EBV-associated lymphoproliferative disease characterized by repeated or sustainable infectious mononucleosis (IM)-like symptoms. EBV is usually detected in B cells in patients who have IM or Burkitt's lymphoma and even in patients with X-linked lymphoproliferative syndrome, which is confirmed to have vulnerability to EBV infection. In contrast, EBV infects T cells (CD4 T, CD8 T, and γδT) or NK cells mono- or oligoclonally in CAEBV patients. Read More

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http://dx.doi.org/10.3389/fped.2019.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369201PMC
February 2019
1 Read

Clinical differentiation of infectious mononucleosis that is caused by Epstein-Barr virus or cytomegalovirus: A single-center case-control study in Japan.

J Infect Chemother 2019 Feb 15. Epub 2019 Feb 15.

Department of General Medicine and Emergency Care, Toho University School of Medicine, Japan.

Introduction: Infectious mononucleosis (IM) is a common viral infection that typically causes fever, pharyngitis, and lymphadenopathy in young patients. The Epstein-Barr virus (EBV) is the most common cause of IM, followed by cytomegalovirus (CMV). Given that serological testing is associated with limitations regarding its accuracy, availability, and time to receive results, clinical differentiation based on symptoms, signs, and basic tests would be useful. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.01.012DOI Listing
February 2019
2 Reads

Detection and virulence potential of a phospholipase D-negative Corynebacterium ulcerans from a concurrent diphtheria and infectious mononucleosis case.

Antonie Van Leeuwenhoek 2019 Feb 15. Epub 2019 Feb 15.

Laboratory of Diphtheria and Corynebacteria of Clinical Relevance - Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro - UERJ, Av. 28 de Setembro, 87 - Fundos, 3° andar. Vila Isabel, Rio de Janeiro, RJ, 20.551, Brazil.

Diphtheria by Corynebacterium ulcerans is increasingly occurring in children, adolescents and adults. In addition to diphtheria toxin (DT), phospholipase D (PLD) is considered a virulence factor of C. ulcerans. Read More

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http://dx.doi.org/10.1007/s10482-019-01240-4DOI Listing
February 2019
3 Reads

Serum amyloid A protein in the course of infectious mononucleosis.

Ther Adv Infect Dis 2019 Jan-Dec;6:2049936118811208. Epub 2019 Jan 17.

Department of General Medicine and Clinical Laboratory, Medical University of Varna, Varna, Bulgaria.

Background: Serum amyloid A (SAA) protein is a major acute phase protein. Increased concentrations have been reported in many inflammatory diseases. In bacterial infections, high levels correlate with those of C-reactive protein (CRP). Read More

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http://dx.doi.org/10.1177/2049936118811208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348571PMC
January 2019
1 Read

Immunoinformatic and systems biology approaches to predict and validate peptide vaccines against Epstein-Barr virus (EBV).

Sci Rep 2019 Jan 24;9(1):720. Epub 2019 Jan 24.

State Key Laboratory of Microbial Metabolism, and College of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.

Epstein-Barr virus (EBV), also known as human herpesvirus 4 (HHV-4), is a member of the Herpesviridae family and causes infectious mononucleosis, Burkitt's lymphoma, and nasopharyngeal carcinoma. Even in the United States of America, the situation is alarming, as EBV affects 95% of the young population between 35 and 40 years of age. In this study, both linear and conformational B-cell epitopes as well as cytotoxic T-lymphocyte (CTL) epitopes were predicted by using the ElliPro and NetCTL. Read More

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http://www.nature.com/articles/s41598-018-37070-z
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http://dx.doi.org/10.1038/s41598-018-37070-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346095PMC
January 2019
9 Reads
5.078 Impact Factor

The International Collaborative on Fatigue Following Infection (COFFI).

Fatigue 2018 19;6(2):106-121. Epub 2018 Jan 19.

Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.

Background: The purpose of the Collaborative on Fatigue Following Infection (COFFI) is for investigators of post-infection fatigue (PIF) and other syndromes to collaborate on these enigmatic and poorly understood conditions by studying relatively homogeneous populations with known infectious triggers. Utilizing COFFI, pooled data and stored biosamples will support both epidemiological and laboratory research to better understand the etiology and risk factors for development and progression of PIF.

Methods: COFFI consists of prospective cohorts from the UK, Netherlands, Norway, USA, New Zealand and Australia, with some cohorts closed and some open to recruitment. Read More

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https://www.tandfonline.com/doi/full/10.1080/21641846.2018.1
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http://dx.doi.org/10.1080/21641846.2018.1426086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333416PMC
January 2018
14 Reads

Defective Epstein-Barr virus in chronic active infection and haematological malignancy.

Nat Microbiol 2019 Mar 21;4(3):404-413. Epub 2019 Jan 21.

Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Epstein-Barr virus (EBV) infection is highly prevalent in humans and is implicated in various diseases, including cancer. Chronic active EBV infection (CAEBV) is an intractable disease classified as a lymphoproliferative disorder in the 2016 World Health Organization lymphoma classification. CAEBV is characterized by EBV-infected T/natural killer (NK) cells and recurrent/persistent infectious mononucleosis-like symptoms. Read More

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http://dx.doi.org/10.1038/s41564-018-0334-0DOI Listing
March 2019
30 Reads

Cold type autoimmune hemolytic anemia- a rare manifestation of infectious mononucleosis; serum ferritin as an important biomarker.

BMC Infect Dis 2019 Jan 18;19(1):68. Epub 2019 Jan 18.

Sri Jayawardanapura General Hospital, Thalapathpitiya, Nugegoda, Western province, Sri Lanka.

Background: Infectious mononucleosis is one of the main manifestations of Epstein - Barr virus, which is characterized by fever, tonsillar-pharyngitis, lymphadenopathy and atypical lymphocytes. Although 60% of patients with IMN develop cold type antibodies, clinically significant hemolytic anemia with a high ferritin level is very rare and validity of serum ferritin as an important biomarker has not been used frequently.

Case Presentation: 18-year-old girl presented with fever, malaise and sore throat with asymptomatic anemia, generalized lymphadenopathy, splenomegaly and mild hepatitis. Read More

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http://dx.doi.org/10.1186/s12879-019-3722-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339345PMC
January 2019
4 Reads

MicroRNAs of Epstein-Barr Virus Attenuate T-Cell-Mediated Immune Control .

MBio 2019 01 15;10(1). Epub 2019 Jan 15.

Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland

The human persistent and oncogenic Epstein-Barr virus (EBV) was one of the first viruses that were described to express viral microRNAs (miRNAs). These have been proposed to modulate many host and viral functions, but their predominant role has remained unclear. We compared recombinant EBVs expressing or lacking miRNAs during infection of mice with reconstituted human immune system components and found that miRNA-deficient EBV replicates to lower viral titers with decreased frequencies of proliferating EBV-infected B cells. Read More

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http://mbio.asm.org/lookup/doi/10.1128/mBio.01941-18
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http://dx.doi.org/10.1128/mBio.01941-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336420PMC
January 2019
10 Reads

Infectious mononucleosis: be aware of its lethality!

Int J Adolesc Med Health 2019 Jan 12;31(1). Epub 2019 Jan 12.

MD, MMedSci, DMSc, Professor of Pediatrics, Department of Pediatrics, Mt Scopus Campus, Hadassah Hebrew University Medical Center and Director, National Institute of Child Health and Human Development, Jerusalem, Israel.

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http://dx.doi.org/10.1515/ijamh-2018-0284DOI Listing
January 2019

CMV-Specific Immune Response-New Patients, New Insight: Central Role of Specific IgG during Infancy and Long-Lasting Immune Deficiency after Allogenic Stem Cell Transplantation.

Int J Mol Sci 2019 Jan 11;20(2). Epub 2019 Jan 11.

Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland.

Although the existing paradigm states that cytomegalovirus (CMV) reactivation is under the control of the cellular immune response, the role of humoral and innate counterparts are underestimated. The study analyzed the host⁻virus interaction i.e. Read More

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http://www.mdpi.com/1422-0067/20/2/271
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http://dx.doi.org/10.3390/ijms20020271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358762PMC
January 2019
12 Reads

[Clinical features of children with Epstein-Barr virus-related acute liver failure: an analysis of four cases].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Dec;20(12):1030-1033

Department of Pediatric Intensive Care Unit, Critical Care Medicine Center of Qingdao Women and Children's Hospital, Qingdao, Shandong 266034, China.

A retrospective analysis was performed for the clinical data of four children with Epstein-Barr virus (EBV)-related acute liver failure. There were two boys and two girls with a median age of 10 months (range 8.5-44 months). Read More

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December 2018
15 Reads

Epstein-Barr Virus Induces Expression of the LPAM-1 Integrin in B Cells and .

J Virol 2019 Mar 19;93(5). Epub 2019 Feb 19.

German Cancer Research Centre (DKFZ), Unit F100, Heidelberg, Germany

Epstein-Barr virus (EBV) infects the oropharynx but, surprisingly, frequently induces B cell proliferation in the gut of immunosuppressed individuals. We found that EBV infection induces the expression of the LPAM-1 integrin on tonsillar B cells and increases it on peripheral blood cells. Similarly, LPAM-1 was induced in the tonsils of patients undergoing primary infectious mononucleosis. Read More

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http://dx.doi.org/10.1128/JVI.01618-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384065PMC
March 2019
4 Reads
4.439 Impact Factor

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to imaging.

Neural Regen Res 2019 Mar;14(3):373-386

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences; Center for Biomedical Imaging at Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA.

Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation, demyelination, and neuronal damage. Environmental and genetic factors are associated with the risk of developing MS, but the exact cause still remains unidentified. Epstein-Barr virus (EBV), vitamin D, and smoking are among the most well-established environmental risk factors in MS. Read More

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http://www.nrronline.org/text.asp?2019/14/3/373/245462
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http://dx.doi.org/10.4103/1673-5374.245462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334604PMC
March 2019
13 Reads

[Epstein-Barr virus primary infection in healthy children].

An Pediatr (Barc) 2018 Oct 24. Epub 2018 Oct 24.

Servicio de Pediatría, Hospital Lluís Alcanyís, Xátiva, Valencia, España.

Introduction: The aim of this study is to assess epidemiological, clinical and laboratory characteristics of primary infection by Epstein-Barr virus (EBV) in children without previous diagnosis of any immune disease and its relationship with clinical presentation.

Patients And Methods: A retrospective study was conducted on all children from 0 to 15 years with IgM against viral capsid of EBV positive or indeterminate during a 22 month period. Epidemiological, clinical and laboratory data were analysed and compared between typical (mononucleosis syndrome) and non-typical clinical symptoms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S16954033183034
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http://dx.doi.org/10.1016/j.anpedi.2018.09.003DOI Listing
October 2018
17 Reads

Immunogenic particles with a broad antigenic spectrum stimulate cytolytic T cells and offer increased protection against EBV infection ex vivo and in mice.

PLoS Pathog 2018 12 6;14(12):e1007464. Epub 2018 Dec 6.

German Cancer Research Center (DKFZ) Unit F100, Heidelberg, Germany.

The ubiquitous Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and is etiologically linked to the development of several malignancies and autoimmune diseases. EBV has a multifaceted life cycle that comprises virus lytic replication and latency programs. Considering EBV infection holistically, we rationalized that prophylactic EBV vaccines should ideally prime the immune system against lytic and latent proteins. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298685PMC
December 2018
4 Reads

Acute Epstein-Barr virus-positive cytotoxic T cell lymphoid hyperplasia in the upper aerodigestive tract, mimicking extranodal natural killer/T cell lymphoma, nasal type.

Virchows Arch 2019 Feb 28;474(2):219-226. Epub 2018 Nov 28.

Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.

To describe the clinicopathological features of nine patients with acute Epstein-Barr virus (EBV)-positive cytotoxic T cell lymphoid hyperplasia (EBV+TLH) in the upper aerodigestive tract, in which initial findings led to a preliminary misdiagnosis of extranodal NK/T cell lymphoma, nasal type (ENKTL). A series of nine cases of EBV+TLH in one Chinese institution over a 9-year interval was retrospectively analyzed. Median age was 16 years (range 5-29 years) with a M:F ratio of 5:4. Read More

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http://dx.doi.org/10.1007/s00428-018-2498-7DOI Listing
February 2019
2 Reads

Complex Investigation of a Pediatric Haematological Case: Haemophagocytic Syndrome Associated with Visceral Leishmaniasis and Epstein⁻Barr (EBV) Co-Infection.

Int J Environ Res Public Health 2018 11 27;15(12). Epub 2018 Nov 27.

Department of Surgical and Biomedical Sciences, Paediatric Clinic, Università degli Studi di Perugia, 06132 Perugia, Italy.

Background: Visceral leishmaniasis (VL) is an anthropozoonosis caused by an intracellular parasite belonging to the genus . In the Mediterranean region, and are responsible for VL and dogs are the main reservoir. Haemophagocytic lymphohistiocytosis (HLH) represents a complication of VL and consists of unrestrained activation and proliferation of lymphocytes and macrophages, leading to uncontrolled immune activation. Read More

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http://dx.doi.org/10.3390/ijerph15122672DOI Listing
November 2018
2 Reads

Epstein-Barr virus and skin.

An Bras Dermatol 2018 Nov/Dec;93(6):786-799

Hospital Cayetano Heredia, Lima, Peru.

Epstein-Barr virus is a DNA virus infecting human beings and could affect 90% of human population. It is crucial to take in account that in Latin America, unlike what happens in developed countries, the exposure to the virus is very early and therefore people have a much longer interaction with the virus. The virus is related to many diseases, mainly the oncological ones, and when the onset is in cutaneous tissue, it can present many clinical variants, as well acute as chronic ones. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20187021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256212PMC
February 2019
12 Reads

Infections of the Oropharynx.

Authors:
Matthew R Klein

Emerg Med Clin North Am 2019 Feb;37(1):69-80

Department of Emergency Medicine, Northwestern University, 211 East Ontario - Suite 300, Chicago, IL 60611, USA. Electronic address:

This article reviews the presentation, diagnosis, and management of common and "can't miss" infections of the oropharynx, including streptococcal pharyngitis, infectious mononucleosis, peritonsillar abscess, retropharyngeal abscess, and epiglottitis. Read More

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http://dx.doi.org/10.1016/j.emc.2018.09.002DOI Listing
February 2019
5 Reads

Acute gastritis caused by concurrent infection with Epstein-Barr virus and cytomegalovirus in an immunocompetent adult.

Clin J Gastroenterol 2018 Nov 16. Epub 2018 Nov 16.

Department of Diagnostic Pathology, Anjo Kosei Hospital, 28 Higashi-hirokute, Anjo-cho, Anjo, Aichi, 446-8602, Japan.

Herein, we describe an extremely rare case of gastritis due to concurrent infection with Epstein-Barr virus (EBV) and cytomegalovirus (CMV) occurring in an immunocompetent adult. The patient was a 35-year-old man who presented with slight fever, nausea, anorexia, weight loss for 3 weeks, mild transaminitis, and leukocytosis with atypical lymphocytes in peripheral blood. The clinical presentation and elevated IgM titers to both EBV-VCA and CMV strongly suggested infectious mononucleosis syndrome caused by co-infection with EBV and CMV. Read More

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http://link.springer.com/10.1007/s12328-018-0924-7
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http://dx.doi.org/10.1007/s12328-018-0924-7DOI Listing
November 2018
16 Reads

Mononucleosis: A Possible Cause of Idiopathic Hypersomnia.

Front Neurol 2018 31;9:922. Epub 2018 Oct 31.

Service de Physiologie Clinique et de l'Exercice (Pole Hospitalier NOL), CHU Nord, Faculté de Médecine Jacques Lisfranc, Université Jean Monnet, SNA EPIS EA 4607, Université de Lyon, Saint-Étienne, France.

Idiopathic hypersomnia (IH) is a rare central hypersomnia of unknown physiopathology. In this study, we determine if the presence of infectious mononucleosis evaluated by serological markers of Epstein Barr virus infection plays a role in this hypersomnia. Ten patients with a suspicion of IH underwent to clinical assessment, 24 h polysomnography, and serologic testing for mononucleosis including Viral Capside Antigen (VCA) IgG, the VCA IgM, and the EBV nuclear antigen (EBNA). Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.00922
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http://dx.doi.org/10.3389/fneur.2018.00922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220045PMC
October 2018
17 Reads

Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity.

Nat Microbiol 2019 Jan 12;4(1):78-88. Epub 2018 Nov 12.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.

The apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like (APOBEC) family of single-stranded DNA (ssDNA) cytosine deaminases provides innate immunity against virus and transposon replication. A well-studied mechanism is APOBEC3G restriction of human immunodeficiency virus type 1, which is counteracted by a virus-encoded degradation mechanism. Accordingly, most work has focused on retroviruses with obligate ssDNA replication intermediates and it is unclear whether large double-stranded DNA (dsDNA) viruses may be similarly susceptible to restriction. Read More

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http://www.nature.com/articles/s41564-018-0284-6
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http://dx.doi.org/10.1038/s41564-018-0284-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294688PMC
January 2019
33 Reads

Emergence of Cytomegalovirus Mononucleosis Syndrome Among Young Adults in Hong Kong Linked to Falling Seroprevalence: Results of a 14-Year Seroepidemiological Study.

Open Forum Infect Dis 2018 Oct 20;5(10):ofy262. Epub 2018 Oct 20.

Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam.

Background: Cytomegalovirus (CMV) mononucleosis is a manifestation of primary CMV infection. This study aims to establish the link between long-term population CMV seroepidemiological trends and incidence of CMV mononucleosis requiring hospitalization. Furthermore, by analyzing serial laboratory data of patients hospitalized with CMV mononucleosis, we aim to provide insights into the natural history of this syndrome. Read More

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https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofy26
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http://dx.doi.org/10.1093/ofid/ofy262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204993PMC
October 2018
14 Reads

2B4 dysfunction in XLP1 NK cells: More than inability to control EBV infection.

Clin Immunol 2018 Nov 2. Epub 2018 Nov 2.

IRCCS Istituto Giannina Gaslini, Dipartimento dei Laboratori di Ricerca, Genoa, Italy; Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genoa, Italy.

X-linked lymphoproliferative disease 1 (XLP1) is a monogenic disorder caused by mutations in SH2D1A, resulting in the absence/dysfunction of the signaling lymphocyte activation molecule (SLAM)-associated protein (SAP). Consequently, SLAM receptors as 2B4 (CD244) and NTB-A (SLAMF6), upon ligand engagement, exert inhibitory instead of activating function. This causes an immune dysfunction that is worsened by the selective inability of NK and T cells to kill EBV-infected B cells with dramatic clinical sequelae (e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616183042
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http://dx.doi.org/10.1016/j.clim.2018.10.022DOI Listing
November 2018
3 Reads

Lung transplantation as a viable option of treatment for pulmonary veno-occlusive disease.

Adv Respir Med 2018 ;86(5):249-254

Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, SDMZ in Zabrze, Medical University of Silesia in Katowice, Silesian Centre for Heart Disease in Zabrze, Poland.

Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension caused by alteration of pulmonary veins. Many clinical and hemodynamic similarities to idiopathic pulmonary arterial hypertension (IPAH) may cause diagnostic and therapeutic difficulties. This case report is about a patient with PVOD, whose first symptoms of the disease occurred after infectious mononucleosis. Read More

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https://journals.viamedica.pl/advances_in_respiratory_medici
Publisher Site
http://dx.doi.org/10.5603/ARM.2018.0040DOI Listing
January 2018
19 Reads