Mutagenic repair of double-stranded DNA breaks in vaccinia virus genomes requires cellular DNA ligase IV activity in the cytosol.
- Rutger David Luteijn,
- Ingo Drexler,
- Geoffrey L Smith,
- Robert Jan Lebbink,
- Emmanuel J H J Wiertz
J Gen Virol 2018 Apr 20. Epub 2018 Apr 20.
1Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Poxviruses comprise a group of large dsDNA viruses that include members relevant to human and animal health, such as variola virus, monkeypox virus, cowpox virus and vaccinia virus (VACV). Poxviruses are remarkable for their unique replication cycle, which is restricted to the cytoplasm of infected cells. The independence from the host nucleus requires poxviruses to encode most of the enzymes involved in DNA replication, transcription and processing. Read More