BAYESIAN RECONSTRUCTION OF THE EVOLUTIONARY HISTORY AND CROSS-SPECIES TRANSITION OF VARIOLA VIRUS AND ORTHOPOXVIRUSES.
- Gianguglielmo Zehender,
- Alessia Lai,
- Carla Veo,
- Annalisa Bergna,
- Massimo Ciccozzi,
- Massimo Galli
J Med Virol 2018 Feb 15. Epub 2018 Feb 15.
Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Milan, Italy.
Variola virus (VARV), the causative agent of smallpox, is an exclusively human virus belonging to the genus Orthopoxvirus, which includes many other viral species covering a wide range of mammal hosts, such as vaccinia, cowpox, camelpox, taterapox, ectromelia and monkeypox virus. The tempo and mode of evolution of Orthopoxviruses were reconstructed using a Bayesian phylodynamic framework by analysing 80 hemagglutinin sequences retrieved from public databases. Bayesian phylogeography was used to estimate their putative ancestral hosts. Read More