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    Seasonal pattern in bipolar disorders and cardio-vascular risk factors: A study from the FACE-BD cohort.
    Chronobiol Int 2017 May 24:1-10. Epub 2017 May 24.
    a AP-HP, GH Saint-Louis - Lariboisière - F. Widal , Département de Psychiatrie et de Médecine Addictologique , Paris , France.
    Seasonal pattern (SP) and metabolic syndrome (MetS) are major contributors to poor outcome in bipolar disorders (BD). Patients with seasonal bipolar depression present increased appetite, carbohydrate cravings, weight gain, and hypersomnia, which can increase the development of MetS. MetS also appears to be associated with seasonal mood changes in the general population. Read More

    Immediate hypersensitivity reaction to pegylated liposomal doxorubicin: management and outcome in four patients.
    Eur J Dermatol 2017 May 19. Epub 2017 May 19.
    Department of Dermatology, Saint-André Hospital CHU Bordeaux, Bordeaux, France, INSERM U1053, Bordeaux Research in Translational Oncology University Bordeaux, Bordeaux, France, French Study Group of Cutaneous Lymphoma (GFELC).
    Hypersensitivity reactions (HSR) to pegylated liposomal doxorubicin (PLD; Caelyx(®)) have been reported, and symptoms usually resolve with drug withdrawal. However, the risk of relapse of severe HSR and prevention remain poorly described. To report the management and outcome in four patients with HSR due to PLD. Read More

    Dermatitis herpetiformis and bone mineral density: analysis of a French cohort of 53 patients.
    Eur J Dermatol 2017 May 19. Epub 2017 May 19.
    Assistance Publique-Hôpitaux de Paris (APHP), Department of Dermatology, Henri Mondor Hospital, Créteil, France, EA 7379 EpiDermE (Epidémiologie en Dermatologie et Evaluation des Thérapeutiques), UPEC, Créteil, France, Université Paris-Est Créteil Val de Marne (UPEC), Créteil, France, Centre d'Investigation Clinique 1430, AP-HP, Créteil, France.
    The characteristics of patients with dermatitis herpetiformis (DH) in France is poorly documented. Furthermore, the risk of fractures and bone mineral density (BMD) in DH remain under-described, and recommendations for systematic screening for osteoporosis in DH are lacking. To describe the characteristics of DH in a large French cohort and evaluate the association between BMD and features of osteoporosis. Read More

    Diabetes and male sex are key risk factor correlates of the extent of coronary artery calcification: A Euro-CCAD study.
    J Diabetes Complications 2017 Mar 31. Epub 2017 Mar 31.
    Department of Public Health and Clinical Medicine, Umeå University and Heart Centre, Umeå, Sweden. Electronic address:
    Background And Aims: Although much has been written about the conventional cardiovascular risk factor correlates of the extent of coronary artery calcification (CAC), few studies have been carried out on symptomatic patients. This paper assesses the potential ability of risk factors to associate with an increasing CAC score.

    Methods: From the European Calcific Coronary Artery Disease (Euro-CCAD) cohort, we retrospectively investigated 6309 symptomatic patients, 62% male, from Denmark, France, Germany, Italy, Spain and the USA. Read More

    Loss of smarce1 expression is a specific diagnostic marker of clear cell meningioma: A comprehensive immunophenotypical and molecular analysis.
    Brain Pathol 2017 May 5. Epub 2017 May 5.
    Department of Neuropathology, Sainte-Anne Hospital, 75014, Paris, France.
    Clear cell meningioma (CCM) is a rare grade II histopathological subtype that usually occurs in young patients and displays high recurrence rate. Germline SMARCE1 mutations have been described in hereditary forms of this disease and more recently in small syndromic and sporadic CCM series. The diagnostic value of SMARCE1 in distinguishing between CCM and other meningioma variants has not been yet established. Read More

    Airborne allergic contact dermatitis caused by isothiazolinones in water-based paints: a retrospective study of 44 cases.
    Contact Dermatitis 2017 Apr 27. Epub 2017 Apr 27.
    Dermatology and Allergology Department, Tenon Hospital (AP-HP), Sorbonne Universities, UPMC University Paris 06, 75020, Paris, France.
    Background: Airborne allergic contact dermatitis caused by paints containing isothiazolinones has been recognized as a health hazard.

    Objectives: To collect epidemiological, clinical and patch test data on airborne allergic contact dermatitis caused by isothiazolinone-containing paints in France and Belgium.

    Methods: A descriptive, retrospective study was initiated by the Dermatology and Allergy Group of the French Society of Dermatology, including methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI)- and/or MI-sensitized patients who developed airborne allergic contact dermatitis following exposure to isothiazolinone-containing paint. Read More

    Neuroimaging findings of postnatally acquired Zika virus infection: a pictorial essay.
    Jpn J Radiol 2017 Apr 26. Epub 2017 Apr 26.
    Department of Radiology, CDPI/DASA, Américas Medical City, Rio De Janeiro, RJ, Brazil.
    Zika virus (ZIKV) is a mosquito-borne arbovirus from the Flaviviridae family, first discovered in 1947. There has been no report of severe complications caused by this virus in humans until recently. However, it is confirmed now that prenatally acquired ZIKV infection may cause severe congenital brain abnormalities in the infected fetuses. Read More

    History of clubfoot treatment, part I: From manipulation in antiquity to splint and plaster in Renaissance before tenotomy.
    Int Orthop 2017 Apr 26. Epub 2017 Apr 26.
    Hopital Europeen Georges Pompidou, 75015, Paris, France.
    Idiopathic clubfoot is one of the most common problems in paediatric orthopaedics. The treatment is controversial and continues to be one of the challenges in paediatric orthopaedics. The aim of this review is to assess the different methods of clubfoot treatment used over the years in light of the documentation present in the literature and art paintings from the antiquity to the end of the 19th century. Read More

    ICU Patients Requiring Renal Replacement Therapy Initiation: Fewer Survivors and More Dialysis Dependents From 80 Years Old.
    Crit Care Med 2017 Apr 21. Epub 2017 Apr 21.
    1Réanimation Médicale, Hôpital Henri Mondor-APHP, Créteil, France. 2Réanimation Médicale, Hôpital Européen Georges Pompidou-APHP, Paris, France. 3Unité de recherche clinique, Hôpital Européen Georges Pompidou-APHP, Paris, France. 4INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.
    Objectives: To assess the role of advanced age on survival and dialysis dependency after initiation of renal replacement therapy for acute kidney injury.

    Design: Retrospective pooled analysis of prospectively collected data.

    Setting: ICUs of two teaching hospitals in Paris area, France. Read More

    A randomized, double-blind, placebo-controlled trial evaluating cysteamine in Huntington's disease.
    Mov Disord 2017 Apr 24. Epub 2017 Apr 24.
    Centre Hospitalier Universitaire d'Angers, Département de Biochimie et Génétique et UMR CNRS 6214 - INSERM U1083 et Institut Mitovasc, Angers, France.
    Background: Cysteamine has been demonstrated as potentially effective in numerous animal models of Huntington's disease.

    Methods: Ninety-six patients with early-stage Huntington's disease were randomized to 1200 mg delayed-release cysteamine bitartrate or placebo daily for 18 months. The primary end point was the change from baseline in the UHDRS Total Motor Score. Read More

    How health-related quality of life assessment should be used in advanced colorectal cancer clinical trials.
    Ann Oncol 2017 Apr 18. Epub 2017 Apr 18.
    Institut Hospitalier Franco-Britannique, Levallois-Perret, France.
    Traditionally, the efficacy of cancer treatment in patients with advance or metastatic disease in clinical studies has been studied using overall survival (OS) and more recently tumor-based endpoints such as progression-free survival, measurements of response to treatment. However, these seem not to be the relevant clinical endpoints in current situation if such endpoints were no validated as surrogate of OS to demonstrate the clinical efficacy. Appropriate, meaningful, primary patient-oriented and patient-reported endpoints that adequately measure the effects of new therapeutic interventions are then crucial for the advancement of clinical research in metastatic colorectal cancer to complement the results of tumor-based endpoints. Read More

    Pathogenesis of immune thrombocytopenia.
    Autoimmun Rev 2017 Jun 17;16(6):620-632. Epub 2017 Apr 17.
    INSERM 1098, Dijon, France; University of Bourgogne/Franche-Comté, Dijon, France; Department of Internal Medicine, Competence Center for Autoimmune Cytopenia, François Mitterrand University Hospital, Dijon, France.
    Immune thrombocytopenia (ITP) is a rare autoimmune disease due to an abnormal T cell response, notably supported by splenic T follicular helper cells, that stimulates the proliferation and differentiation of autoreactive B cells. The antiplatelet autoantibodies they produce facilitate platelet phagocytosis by macrophages, essentially in the spleen. Macrophages contribute to the perpetuation of the auto-immune response as the main antigen-presenting cell during ITP. Read More

    Fatigue in multiple sclerosis - Insights into evaluation and management.
    Neurophysiol Clin 2017 Apr 23;47(2):139-171. Epub 2017 Apr 23.
    EA 4391, excitabilité nerveuse et thérapeutique, université Paris-Est-Créteil, Créteil, France; Service de physiologie-explorations fonctionnelles, hôpital Henri-Mondor, Assistance publique-Hôpitaux de Paris, 51, avenue de Lattre-de-Tassigny, 94010 Créteil, France.
    Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system, characterized by the accumulation of numerous neurological symptoms and signs throughout its course. Fatigue is one of the most distressing complaints that MS patients may experience over their lifetime. In spite of its high prevalence, the pathophysiology of MS fatigue is far from being fully elucidated and a constellation of mechanisms seems implicated in this setting. Read More

    Clinical Calculator for Early Mortality in Metastatic Colorectal Cancer: An Analysis of Patients From 28 Clinical Trials in the Aide et Recherche en Cancérologie Digestive Database.
    J Clin Oncol 2017 Apr 17:JCO2016715771. Epub 2017 Apr 17.
    Lindsay A. Renfro, Axel Grothey, and Daniel J. Sargent, Mayo Clinic, Rochester, MN; Richard M. Goldberg, The Ohio State University, Columbus, OH; Alberto Sobrero, Ospedale San Martino, Genoa; Alfredo Falcone, University Hospital of Pisa, Pisa, Italy; Richard Adams, Cardiff University, Cardiff; Matthew T. Seymour, St James's Hospital and University of Leeds, Leeds, United Kingdom; Volker Heinemann, University of Munich, Munich; Hans-Joachim Schmoll, University Clinic Halle (Saale), Halle; Rainer Porschen, Klinikum Bremen-Ost Klinik für Innere Medizin, Bremen; Carsten Bokemeyer, University Hospital, Hamburg-Eppendorf, Germany; Jean-Yves Douillard, Centre René Gauducheau, Nantes; Christophe Tournigand, University of Paris Est Creteil; Christophe Tournigand, Assistance Hopitaux Publique de Paris Henri-Mondor Hospital, Créteil; Benoist Chibaudel and Aimery de Gramont, Franco-British Institute, Levallois-Perret, France; Herbert Hurwitz, Duke University Medical Center, Durham, NC; Charles S. Fuchs; Dana-Farber Cancer Institute, Boston, MA; Eduardo Diaz-Rubio, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain; Paulo M. Hoff, Hospital Sírio-Libanês and University of São Paulo, São Paulo, Brazil; Fairooz F. Kabbinavar and J. Randolph Hecht, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA; Niall C. Tebbutt, Austin Health, Heidelberg, Victoria, Australia; Cornelis J.A. Punt, University of Amsterdam, Amsterdam, the Netherlands; John Souglakos, University of Crete, Heraklion, Greece; Eric Van Cutsem, University Hospital Leuven, Leuven, Belgium; and Leonard Saltz, Memorial Sloan Kettering Cancer Center, New York, NY.
    Purpose Factors contributing to early mortality after initiation of treatment of metastatic colorectal cancer are poorly understood. Materials and Methods Data from 22,654 patients enrolled in 28 randomized phase III trials contained in the ARCAD (Aide et Recherche en Cancérologie Digestive) database were pooled. Multivariable logistic regression models for 30-, 60-, and 90-day mortality were constructed, including clinically and statistically significant patient and disease factors and interaction terms. Read More

    The treatment of fatigue by non-invasive brain stimulation.
    Neurophysiol Clin 2017 Apr 11;47(2):173-184. Epub 2017 Apr 11.
    EA 4391, faculté de médecine de Créteil, université Paris Est Créteil, Créteil, France; Department of Neurology, Philipps University, Marburg, Germany; Department of Neurology, Center for Neurorehabilitation, Valens, Switzerland.
    The use of non-invasive brain neurostimulation (NIBS) techniques to treat neurological or psychiatric diseases is currently under development. Fatigue is a commonly observed symptom in the field of potentially treatable pathologies by NIBS, yet very little data has been published regarding its treatment. We conducted a review of the literature until the end of February 2017 to analyze all the studies that reported a clinical assessment of the effects of NIBS techniques on fatigue. Read More

    IL4-induced gene 1 promotes tumor growth by shaping the immune microenvironment in melanoma.
    Oncoimmunology 2017 13;6(3):e1278331. Epub 2017 Jan 13.
    Inserm, U1016, Institut Cochin, Paris, France; Cnrs, UMR8104, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
    Amino acid catabolizing enzymes emerged as a crucial mechanism used by tumors to dampen immune responses. The L-phenylalanine oxidase IL-4 induced gene 1 (IL4I1) is expressed by tumor-associated myeloid cells of most solid tumors, including melanoma. We previously provided the only evidence that IL4I1 accelerates tumor growth by limiting the CD8(+) T cell mediated immune response, in a mouse model of melanoma cell transplantation. Read More

    Ombitasvir, paritaprevir, and ritonavir plus ribavirin in adults with hepatitis C virus genotype 4 infection and cirrhosis (AGATE-I): a multicentre, phase 3, randomised open-label trial.
    Lancet Gastroenterol Hepatol 2016 Sep 16;1(1):25-35. Epub 2016 Jun 16.
    AbbVie Inc, North Chicago, IL, USA.
    Background: Hepatitis C virus (HCV) genotype 4 infection is most commonly reported in sub-Saharan Africa and the Middle East; however, prevalence is increasing worldwide through immigration. HCV genotype 4 accounts for 20% of all infections, but clinical trial data for treatment remain limited. We assessed the combination of two direct-acting antivirals, ombitasvir (NS5A inhibitor) and paritaprevir (NS3/4A protease inhibitor; co-dosed with ritonavir) plus ribavirin in patients with HCV genotype 4 infection and compensated cirrhosis. Read More

    Embodied emotion impairment in Huntington's Disease.
    Cortex 2017 Mar 18;92:44-56. Epub 2017 Mar 18.
    École Normale Supérieure, Institut d'Étude de la Cognition, Paris, France; Inserm U955-E01, Institut Mondor de Recherche Biomédicale, Créteil, France; Université Paris Est Créteil, Medical Faculty, Créteil, France; Assistance Publique-Hôpitaux de Paris, Huntington's Disease Reference Center, Groupe Henri-Mondor Albert-Chenevier, Créteil, France.
    Theories of embodied cognition suggest that perceiving an emotion involves somatovisceral and motoric re-experiencing. Here we suggest taking such an embodied stance when looking at emotion processing deficits in patients with Huntington's Disease (HD), a neurodegenerative motor disorder. The literature on these patients' emotion recognition deficit has recently been enriched by some reports of impaired emotion expression. Read More

    Tackling psychosocial maladjustment in Parkinson's disease patients following subthalamic deep-brain stimulation: A randomised clinical trial.
    PLoS One 2017 11;12(4):e0174512. Epub 2017 Apr 11.
    Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.
    Background: Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for the motor and non-motor signs of Parkinson's disease (PD), however, psychological disorders and social maladjustment have been reported in about one third of patients after STN-DBS. We propose here a perioperative psychoeducation programme to limit such social and familial disruption.

    Methods: Nineteen PD patients and carers were included in a randomised single blind study. Read More

    Nab-paclitaxel plus either gemcitabine or simplified leucovorin and fluorouracil as first-line therapy for metastatic pancreatic adenocarcinoma (AFUGEM GERCOR): a non-comparative, multicentre, open-label, randomised phase 2 trial.
    Lancet Gastroenterol Hepatol 2017 May 28;2(5):337-346. Epub 2017 Feb 28.
    Department of Oncology, Institut Mutualiste Montsouris, Paris, France.
    Background: Nab-paclitaxel plus gemcitabine has become a standard treatment regimen in patients with metastatic pancreatic adenocarcinoma; however, retrospective data suggest that gemcitabine might be inefficient in 50-60% of patients and thus not an optimum regimen in combination with nab-paclitaxel. We did a phase 2 trial to assess the activity and safety of a new regimen of nab-paclitaxel plus simplified leucovorin and fluorouracil.

    Methods: We did a non-comparative, multicentre, open-label, randomised phase 2 trial in 15 hospitals and institutions in France. Read More

    Natural non-homologous recombination led to the emergence of a duplicated V3-NS5A region in HCV-1b strains associated with hepatocellular carcinoma.
    PLoS One 2017 10;12(4):e0174651. Epub 2017 Apr 10.
    IRHS, Université d'Angers, SFR4207 QUASAV, Angers, France.
    Background: The emergence of new strains in RNA viruses is mainly due to mutations or intra and inter-genotype homologous recombination. Non-homologous recombinations may be deleterious and are rarely detected. In previous studies, we identified HCV-1b strains bearing two tandemly repeated V3 regions in the NS5A gene without ORF disruption. Read More

    Venoarterial extracorporeal membrane oxygenation after coronary artery bypass grafting: Results of a multicenter study.
    Int J Cardiol 2017 Mar 28. Epub 2017 Mar 28.
    Department of Cardiothoracic Surgery, University Hospital Muenster, Muenster, Germany.
    Background: The evidence of the benefits of using venoarterial extracorporeal membrane oxygenation (VA-ECMO) after coronary artery bypass grafting (CABG) is scarce.

    Methods: We analyzed the outcomes of patients who received VA-ECMO therapy due to cardiac or respiratory failure after isolated CABG in 12 centers between 2005 and 2016. Patients treated preoperatively with ECMO were excluded from this study. Read More

    APN/CD13 is over-expressed by Psoriatic fibroblasts and is modulated by CGRP and IL-4 but not by retinoic acid treatment.
    J Cell Physiol 2017 Apr 7. Epub 2017 Apr 7.
    Laboratory of Cellular and Molecular Basis of Normal Hematopoiesis and Hematological Disorders, INSERM UMR 1163, Paris, France.
    Psoriasis vulgaris is a common skin inflammatory disease characterized by recurrent flare episodes associated with scaly well-demarcated skin plaques. Skin biopsies from psoriatic patients with high PASI score (22.67 ± 8. Read More

    Impact of genotype and phenotype on cardiac biomarkers in patients with transthyretin amyloidosis - Report from the Transthyretin Amyloidosis Outcome Survey (THAOS).
    PLoS One 2017 6;12(4):e0173086. Epub 2017 Apr 6.
    Amyloidosis Network, Department of Cardiology, CHU Henri Mondor, Creteil, France.
    Aim: Cardiac troponins and natriuretic peptides are established for risk stratification in light-chain amyloidosis. Data on cardiac biomarkers in transthyretin amyloidosis (ATTR) are lacking.

    Methods And Results: Patients (n = 1617) with any of the following cardiac biomarkers, BNP (n = 1079), NT-proBNP (n = 550), troponin T (n = 274), and troponin I (n = 108), available at baseline in the Transthyretin Amyloidosis Outcomes Survey (THAOS) were analyzed for differences between genotypes and phenotypes and their association with survival. Read More

    Lenalidomide, Bortezomib, and Dexamethasone with Transplantation for Myeloma.
    N Engl J Med 2017 04;376(14):1311-1320
    From the Institut Universitaire du Cancer de Toulouse-Oncopole (M.A., M.R., C.P., S.R., H.A.-L.) and Service d'Epidémiologie, Centre Hospitalier et Universitaire de Toulouse (V.L.-C.), Toulouse, Hôpital Haut-Lévêque, Bordeaux Pessac (C.H.), Centre Hospitalier et Universitaire la Miletrie, Poitiers (X.L.), Centre Hospitalier Le Bocage, Dijon (D.C.), Centre Hospitalier et Universitaire de Rennes, Rennes (M.E.), Hôpital St.-Louis (B.A., J.P.F.), Centre Hospitalier Universitaire, Hôpital St.-Antoine (L.G.), Institut Curie (C.M.), and Haute Autorité de Santé (J.-L.H.), Paris, Institut d'Hématologie de Basse Normandie, Centre Hospitalier et Universitaire de Caen, Caen (M.M.), Centre Hospitalier et Universitaire Henri Mondor, Creteil (K.B.), Hôpital Claude Huriez, Lille (T.F.), and Hôtel Dieu, Nantes (P.M.) - all in France; Institut Jules Bordet, Brussels (N. Meuleman); and Dana-Farber Cancer Institute, Boston (M.E.M., A.A.Z., E.A.W., N. Munshi, K.C.A., P.G.R.).
    Background: High-dose chemotherapy plus autologous stem-cell transplantation has been the standard treatment for newly diagnosed multiple myeloma in adults up to 65 years of age. However, promising data on the use of combination therapy with lenalidomide, bortezomib, and dexamethasone (RVD) in this population have raised questions about the role and timing of transplantation.

    Methods: We randomly assigned 700 patients with multiple myeloma to receive induction therapy with three cycles of RVD and then consolidation therapy with either five additional cycles of RVD (350 patients) or high-dose melphalan plus stem-cell transplantation followed by two additional cycles of RVD (350 patients). Read More

    Decision making tools in prostate cancer: from risk grouping to nomograms.
    Minerva Urol Nefrol 2017 Mar 30. Epub 2017 Mar 30.
    Department of Urology, University of Modena and Reggio Emilia, Modena, Italy.
    Introduction: Prostate cancer (PCa) is the most common solid neoplasm and the second leading cause of cancer death in men. After the Partin tables were developed, a number of predictive and prognostic tools became available for risk stratification. These tools have allowed the urologist to better characterize this disease and lead to more confident treatment decisions for patients. Read More

    External validation of a nomogram for identification of pathologically favorable disease in intermediate risk prostate cancer patients.
    Prostate 2017 Jun 2;77(8):928-933. Epub 2017 Apr 2.
    Department of Urology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
    Objective: To establish an external validation of the new nomogram from Gandaglia et al which provides estimates of the probability of pathological favorable disease in pre-operatively defined intermediate-risk PCa.

    Patients And Methods: Overall, 2928 intermediate-risk PCa patients according to the D'Amico classification undergoing RP and bilateral lymph node dissection in seven academic centres between 2000 and 2011. Pathologically favorable PCa was defined as low-grade organ-confined disease. Read More

    A re-examination of antidepressant treatment-emergent mania in bipolar disorders: evidence of gender differences.
    Acta Psychiatr Scand 2017 May 1;135(5):479-488. Epub 2017 Apr 1.
    Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
    Objective: To explore the prevalence and clinical profile of males and females who develop antidepressant treatment-emergent mania (ATEM).

    Method: From an original sample of 754 patients with BD, we identified ATEM+ cases (n = 75) and ATEM- controls (n = 135) that met stringent criteria. We specifically examined the combinations of clinical factors that best classified males and females as ATEM+ cases. Read More

    HCV core antigen as an alternate test to HCV RNA for assessment of virologic responses to all-oral, interferon-free treatment in HCV genotype 1 infected patients.
    J Virol Methods 2017 Jul 27;245:14-18. Epub 2017 Mar 27.
    National Reference Center for Viral Hepatitis B C and D Department of Virology Hôpital Henri Mondor Université Paris-Est and INSERM U955, Créteil, France.
    In light of the advances in HCV therapy, simplification of diagnosis confirmation, pre- treatment diagnostic workup and treatment monitoring is required to ensure broad access to interferon-free therapies. HCV core antigen (HCV cAg) testing is rapid, giving results in approximately 60min, and less expensive than HCV RNA methods. While extensive data on the analytical performance of HCV cAg relative to RNA or comparisons in longitudinal studies of patients on interferon based (response guided) therapy there is very limited data on the relative performance of HCV cAg in diagnosis and monitoring patients receiving all-oral interferon free regimens. Read More

    Outcome of Lower-Risk Patients With Myelodysplastic Syndromes Without 5q Deletion After Failure of Erythropoiesis-Stimulating Agents.
    J Clin Oncol 2017 May 28;35(14):1591-1597. Epub 2017 Mar 28.
    Sophie Park, Centre Hospitalier Universitaire (CHU) Grenoble Alpes, Université Grenoble Alpes, Grenoble; Jean-François Hamel and Sylvain Thépot, CHU d'Angers; Sylvain Thépot, Université d'Angers, Institut National de la Santé et de la Recherche Médicale, Unité 1232, and LabEx IGO, Angers; Andrea Toma, CHU Henri Mondor, Assistance Publique Hôpitaux de Paris (AP-HP), Université Paris-Est Créteil; Rosa Sapena and Pierre Fenaux, CHU Saint Louis, AP-HP, Université Paris X; François Dreyfus, CHU Cochin, AP-HP, Université Paris V, Paris; Charikleia Kelaidi, CHU Avicenne, Avicenne; Odile Beyne-Rauzy, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse; Aspasia Stamatoullas, Centre Henri Becquerel, Rouen; Agnès Guerci-Bresler, CHU Nancy, Nancy; Dominique Bordessoule, CHU Dupuytren, Limoges; Pascale Cony-Makhoul, Centre Hospitalier Annecy Genevois, Epagny Metz-Tessy; Stéphane Cheze, CHU de Caen, Caen; Eric Wattel, Centre Hospitalier Lyon-Sud, Pierre Bénite, Lyon; Christian Rose, Université Catholique de Lille, Lille; Norbert Vey, Institut Paoli-Calmettes Marseille, Marseille, France; Maria Diez Campelo, Hospital Universitario de Salamanca, Salamanca; Teresa Bernal, Hospital Central de Asturias, Oviedo; Fernando Ramos, Hospital de León, León; Marisa Calabuig, Hospital Clínico de Valencia; Guillermo F. Sanz, Hospital Universitario y Politecnico La Fe, Valencia, Spain; Valeria Santini and Alessandro Sanna, Azienda Ospedaliero Universitaria (AOU) Careggi and University of Florence, Florence; Enrico Balleari, Istituto di Ricovero e Cura a Carattere Scientifico AOU San Martino di Genova, Genova; Daniela Gioia, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria; Dario Ferrero, Università degli Studi di Torino; Gianluca Gaidano, Amedeo Avogadro University of Eastern Piedmont, Torino; Giovanni Cametti, Ospedale Maggiore di Chieri, Chieri; Fabrizio Pane, Università Federico II, Napoli, Italy; Mikkael A. Sekeres and Jaime Fensterl, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH; Rami Komrokji, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; David P. Steensma, Dana-Farber Cancer Institute, Boston, MA; Gail J. Roboz, Weill Medical College of Cornell University, New York, NY; Jennifer Kaivers and Ulrich Germing, University of Düsseldorf, Düsseldorf; Katharina Götze and Catharina Müller-Thomas, Universität München, München, Germany; and Ioannis Kotsianidis, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
    Purpose Most anemic patients with non-deleted 5q lower-risk myelodysplastic syndromes (MDS) are treated with erythropoiesis-stimulating agents (ESAs), with a response rate of approximately 50%. Second-line treatments, including hypomethylating agents (HMAs), lenalidomide (LEN), and investigational drugs, may be used after ESA failure in some countries, but their effect on disease progression and overall survival (OS) is unknown. Here, we analyzed outcome after ESA failure and the effect of second-line treatments. Read More

    Opioids and nonopioids for postoperative pain control in patients with chronic kidney disease.
    J Opioid Manag 2017 Jan/Feb;13(1):17-25
    Department of Nephrology and Transplantation, Henri Mondor Hospital, AP-HP, Paris Est University, Creteil, France.
    Objectives: To evaluate postoperative pain management (POPM) practices by anesthesiologists caring for patients with chronic kidney disease (CKD).

    Design: Prospective one-time survey endorsed by the French Society of Anesthesia and Intensive Care (SFAR).

    Setting: A self-administered online questionnaire was distributed to members of SFAR nationally. Read More

    First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): a prospective, multicentre, parallel-group, open-label randomised trial.
    Lancet 2017 May 22;389(10083):2031-2040. Epub 2017 Mar 22.
    Department of Dermatology, Rouen University Hospital and INSERM U1234, Centre de référence des maladies bulleuses autoimmunes, Normandie University, Rouen, France.
    Background: High doses of corticosteroids are considered the standard treatment for pemphigus. Because long-term corticosteroid treatment can cause severe and even life-threatening side-effects in patients with this disease, we assessed whether first-line use of rituximab as adjuvant therapy could improve the proportion of patients achieving complete remission off-therapy, compared with corticosteroid treatment alone, while decreasing treatment side-effects of corticosteroids.

    Methods: We did a prospective, multicentre, parallel-group, open-label, randomised trial in 25 dermatology hospital departments in France (Ritux 3). Read More

    Survival following redo hepatectomy vs radiofrequency ablation for recurrent hepatocellular carcinoma: a systematic review and meta-analysis.
    HPB (Oxford) 2017 Jan 27;19(1):3-9. Epub 2016 Oct 27.
    Department of HPB Surgery and Liver Transplantation, Henri Mondor University Hospital, Créteil, France; INSERM U 955, Créteil, France. Electronic address:
    Background: Redo hepatic resection (RHR) and radiofrequency ablation (RFA) are salvage treatment choices for recurrent hepatocellular carcinoma (RHCC). As yet, it is unclear as to which treatment modality is superior in terms of long term survival. The aim of this study was to compare the survival benefits and treatment efficacy of RHR and RFA for recurrent HCC. Read More

    Risk of rectal neoplasia after colectomy and ileorectal anastomosis for ulcerative colitis.
    J Crohns Colitis 2017 Feb 21. Epub 2017 Feb 21.
    Department of Gastroenterology, IBD and nutritive assistance, Hôpital Beaujon, APHP, Clichy, France.
    Introduction-: Colectomy can be required in the management of ulcerative colitis (UC). While ileal pouch anal-anastomosis (IPAA) is the recommended reconstruction technique, ileorectal anastomosis (IRA) is still performed and might present some advantages. However, the risk of rectal neoplasia might limit its indication. Read More

    Contribution of Ultra Deep Sequencing in the Clinical Diagnosis of a New Fungal Pathogen Species: Basidiobolus meristosporus.
    Front Microbiol 2017 7;8:334. Epub 2017 Mar 7.
    Département de Microbiologie, Créteil, Dynamyc, ENVA, UPEC Creteil, France.
    Some cases of fungal infection remained undiagnosed, especially when the pathogens are uncommon, require specific conditions for in vitro growth, or when several microbial species are present in the specimen. Ultra-Deep Sequencing (UDS) could be considered as a precise tool in the identification of involved pathogens in order to upgrade patient treatment. In this study, we report the implementation of UDS technology in medical laboratory during the follow-up of an atypical fungal infection case. Read More

    ELITA consensus statements on use of DAAs in liver transplant candidates and recipients.
    J Hepatol 2017 Mar 18. Epub 2017 Mar 18.
    Hepatology& Liver Transplantation Unit, Hospital Universitari I Politècnic La Fe, University of Valencia & Ciberhed, Valencia, Spain.
    The advent of safe and highly effective direct acting antivirals (DAA) had huge implications for the HCV transplant field and changed our management of both, patients on the waiting list and those with HCV graft reinfection after Liver Transplantation (LT). When treating HCV infection before LT, HCV reinfection of the graft may be prevented in nearly all patients. In addition some candidates show a remarkable clinical improvement and are possibly delisted. Read More

    Quality of Life, Burden of Disease, Co-morbidities, and Systemic Effects in Vitiligo Patients.
    Dermatol Clin 2017 Apr;35(2):117-128
    Department of Dermatology, EpiDermE, Henri Mondor Hospital, Université Paris-Est Créteil Val-de-Marne, 51 Avenue du Maréchal de Lattre de Tassigny, Créteil 94010, France.
    Vitiligo is a complex, systemic disease associated with many autoimmune and autoinflammatory conditions. Additionally, the cutaneous changes of vitiligo have significant effects on quality of life and self-esteem. Further efforts are needed to increase our understanding of vitiligo comorbidities as well as to increase awareness of the psychological effects of vitiligo. Read More

    Brain FDG-PET metabolic abnormalities in Macrophagic Myofasciitis: Are They Stable?
    J Nucl Med 2017 Mar 16. Epub 2017 Mar 16.
    CHU Henri Mondor, France.
    We address this letter in addition to our recent published study (1). The aim is to add some insight to the evolution of the brain abnormalities that are observed with macrophagic myofasciitis (MMF). MMF is a chronic disease whom evolution is slow and symptoms first may occurs from months to year after a vaccination containing aluminium hydroxid adjuvants (2). Read More

    Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks.
    Haematologica 2017 Mar 16. Epub 2017 Mar 16.
    Eurocord, Paris-Diderot University; Monacord, Centre Scientifique de Monaco.
    Efforts to implement family cord blood banking have been developed in the past decades for siblings requiring stem cell transplantation for conditions such as sickle cell disease. However, public banks are faced with challenging decisions about the units to be stored, discarded, or used for other endeavors. We report here 20 years of experience in family cord blood banking for sickle cell disease in two dedicated public banks. Read More

    Reassessing the clinical spectrum associated with hereditary leiomyomatosis and renal cell carcinoma syndrome in French FH mutation carriers.
    Clin Genet 2017 Mar 16. Epub 2017 Mar 16.
    Département de Médecine Oncologique, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
    We addressed uncertainties regarding hereditary leiomyomatosis and renal cell carcinoma (HLRCC) by exploring all French cases, representing the largest series to date. Fumarate hydratase (FH) germline testing was performed with Sanger sequencing and qPCR/MLPA. Enzyme activity was measured when necessary. Read More

    Liver transplantation versus liver resection for hepatocellular carcinoma in intention to treat: Attempt to perform an ideal meta-analysis.
    Liver Transpl 2017 Mar 14. Epub 2017 Mar 14.
    Department of Hepato-biliary Surgery and Liver Transplantation, University Hospital of Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, Créteil Cedex, 94000, France.
    Objective This meta-analysis compared the effects of liver transplantation (LT) and liver resection (LR) on overall survival (OS) and disease-free survival (DFS) in patients with hepatocellular carcinoma (HCC) small transplantable HCC or within Milan criteria. Methods Articles comparing LR with LT for HCC, based on Milan criteria or small size, published until June 2015 were selected and a meta-analysis performed. Results No randomized controlled trial (RCT) has been published to date comparing survival outcomes in patients with HCC who underwent LR and LT. Read More

    Deciphering the mechanism of Q145H SFTPC mutation unmasks a splicing defect and explains the severity of the phenotype.
    Eur J Hum Genet 2017 Jun 15;25(6):779-782. Epub 2017 Mar 15.
    INSERM, Créteil, France.
    Mutations in the gene encoding surfactant protein C (SFTPC) have led to a broad range of phenotypes from neonatal respiratory distress syndrome to adult interstitial lung disease. We previously identified the c.435G>C variant in the SFTPC gene associated with fatal neonatal respiratory distress syndrome in an infant girl. Read More

    Improved Fetal Hemoglobin With mTOR Inhibitor-Based Immunosuppression in a Kidney Transplant Recipient With Sickle Cell Disease.
    Am J Transplant 2017 Mar 9. Epub 2017 Mar 9.
    Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.
    Fetal hemoglobin induction is a key point in the management of sickle cell disease (SCD). We report the case of a kidney transplant recipient with SCD who was treated with everolimus, a mammalian target of rapamycin inhibitor. At 10 months after initiating therapy, the patient's fetal hemoglobin level was dramatically increased (from 4. Read More

    Ophthalmic manifestations in IgG4-related disease: Clinical presentation and response to treatment in a French case-series.
    Medicine (Baltimore) 2017 Mar;96(10):e6205
    aMédecine Interne, Groupe Hospitalier Timone, AP-HM, Aix-Marseille Université, Marseille bMédecine Interne, Hopital Cochin, Université Paris-Descartes, Paris cMédecine Interne, Centre hospitalier de Pau, Pau dCHRU-Hôpital Claude Huriez, Université de Lille, Lille eMédecine Interne, Groupe hospitalier Pitie Salpêtrière AP-HP, Université Pierre et Marie Curie, Paris fMédecine interne, CHU le Bocage, Université de Bourgogne, Dijon gMédecine Interne, CHU Rennes, Rennes hMédecine interne, CHU Mondor, Créteil iCHG Saint Denis de la Réunion, Réunion, France.
    IgG4-related disease (IgG4-RD) is characterized by variable tissue or organ involvements sharing common pathological findings. Orbital or orbital adnexa involvement of the disease has been reported in a few case series. The aim of our study was to characterize and analyze ophthalmic manifestations from a nationwide French case-series. Read More

    Real-World Efficacy of Daclatasvir and Sofosbuvir, With and Without Ribavirin, in HIV/HCV Coinfected Patients With Advanced Liver Disease in a French Early Access Cohort.
    J Acquir Immune Defic Syndr 2017 May;75(1):97-107
    1Department of Infectious and Tropical Diseases, Hôpitaux Universitaires Saint-Antoine, Assistance Publique Hôpitaux de Paris (APHP), Paris, France; 2Sorbonne Universités, INSERM, UPMC Univ Paris 06, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP UMRS 1136), Paris, France; 3Hepatology Unit, Cochin Hospital, APHP, INSERM USM20, Pasteur Institute, Paris, France; 4Department of Infectious Diseases, CHU de la Conception, Marseilles, France; 5Department of Hepato-gastroenterology, CHU Purpan, Toulouse, France; 6Department of Internal Medicine and COREVIH PACA-EST, CHU Archet, Nice, France; 7Hepatobiliary Centre, CHU Paul-Brousse, Villejuif, France; 8Department of Infectious and Tropical Diseases, CHU Pitié-Salpêtrière, Paris, France; 9Department of Infectious and Tropical Diseases, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France; 10Department of Infectious and Tropical Diseases, Bichat-Claude Bernard Hospital, Paris, France; 11Department of Clinical Immunology, Georges-Pompidou European Hospital, Paris, France; 12Department of Hepato-gastroenterology, CHU de Montpellier, Montpellier, France; 13Department of Infectious and Tropical Diseases, Hôpitaux Universitaires Tenon, APHP, Paris, France; 14Department of Infectious and Tropical Diseases, CHU Perpignan, Perpignan, France; 15Department of Clinical Immunology, CHU Henri Mondor, Créteil, France; 16Department of Hemato-oncology, CH Aix-en-Provence, Aix-en-Provence, France; 17Department of Infectious Diseases, CHU Toulon, Toulon, France; 18Department of Infectious and Tropical Diseases, CHU Hôtel Dieu, Nantes, France; 19Department of Infectious Diseases, Raymond Poincaré Hospital, APHP, Garches, France; 20Department of Internal Medicine, CHD La Roche-sur-Yon, La Roche-sur-Yon, France; 21Department of Hepato-gastroenterology, CHU Grenoble Alpes, Grenoble, France; 22Hepatic Fibrosis Investigation Centre, Haut-Lévêque Hospital, CHU de Bordeaux, Pessac, France; 23INSERM U1223, Pasteur Institute, Paris-Descartes University and Hepatology Department, Cochin Hospital, Paris, France; 24INSERM U1219, ISPED University of Bordeaux, Bordeaux, France; 25Bristol-Myers Squibb Research and Development, Princeton, NJ; 26Bristol-Myers Squibb Research and Development, Rueil-Malmaison, Paris, France; and 27Paris Descartes University, Paris, France.
    Background: Efficacious, well-tolerated, direct antiviral agents have drastically changed the prognosis of hepatitis C virus (HCV) disease, but real-world data for oral treatments are limited in key populations such as HIV/HCV coinfection with advanced liver disease. Daclatasvir (DCV) efficacy and safety was assessed in the French "Autorisation Temporaire d'Utilisation" (ATU) program, providing DCV ahead of market authorization to patients with advanced HCV disease without other treatment options.

    Methods: This was a subanalysis of HIV/HCV coinfected ATU patients treated with DCV plus sofosbuvir (SOF). Read More

    Multimorbidity and healthcare utilization among home care clients with dementia in Ontario, Canada: A retrospective analysis of a population-based cohort.
    PLoS Med 2017 Mar 7;14(3):e1002249. Epub 2017 Mar 7.
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
    Background: For community-dwelling older persons with dementia, the presence of multimorbidity can create complex clinical challenges for both individuals and their physicians, and can contribute to poor outcomes. We quantified the associations between level of multimorbidity (chronic disease burden) and risk of hospitalization and risk of emergency department (ED) visit in a home care cohort with dementia and explored the role of continuity of physician care (COC) in modifying these relationships.

    Methods And Findings: A retrospective cohort study using linked administrative and clinical data from Ontario, Canada, was conducted among 30,112 long-stay home care clients (mean age 83. Read More

    Prognostic value of PLA2R autoimmunity detected by measurement of anti-PLA2R antibodies combined with detection of PLA2R antigen in membranous nephropathy: A single-centre study over 14 years.
    PLoS One 2017 3;12(3):e0173201. Epub 2017 Mar 3.
    Assistance Publique-Hôpitaux de Paris, Hôpital Tenon, Department of Nephrology and Dialysis, Paris, France.
    Introduction: Clinical course of membranous nephropathy (MN) is difficult to predict. Measurement of circulating anti-PLA2R autoantibodies (PLA2R-Ab) and detection in immune deposits of PLA2R antigen (PLA2R-Ag) are major advances in disease understanding. We evaluated the clinical significance of these biomarkers. Read More

    Elbasvir/Grazoprevir for Patients With Hepatitis C Virus Infection and Inherited Blood Disorders: A Phase III Study.
    Hepatology 2017 Mar 3. Epub 2017 Mar 3.
    University of Palermo, Palermo, Italy.
    Direct-acting antiviral agents have not been studied exclusively in patients with inherited blood disorders and hepatitis C virus (HCV) infection. The objective of the randomized, placebo-controlled, phase III C-EDGE IBLD study was to assess the safety and efficacy of elbasvir/grazoprevir (EBR/GZR) in patients with inherited bleeding disorders and HCV infection. One hundred fifty-nine adults with HCV infection and sickle cell anemia, thalassemia, or hemophilia A/B or von Willebrand disease were enrolled at 31 study sites in the United States, Europe, Australia, Canada, Israel, and Thailand. Read More

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