2,766 results match your criteria Mondor Disease


Single Dose Daily Fractionated Is Not Inferior To Twice A Day Fractionated Total Body Irradiation Prior To Allogeneic Stem Cell Transplantation For Acute Leukemia: A Useful Practice Simplification Resulting From The Sarasin Study.

Int J Radiat Oncol Biol Phys 2018 Jun 18. Epub 2018 Jun 18.

EBMT Paris study office, Department of Hematology and Cell Therapy, INSERM U938, Hopital Saint Antoine and University UPMC, Paris, France; Hematology division BMT and cord blood bank, Chaim Sheba Medical Center, Tel-Hashomer, Israel.

Purpose: Total-body irradiation (TBI) is a major constituent of myeloablative conditioning regimens. The standard technique consists of 12Gy in 6 fractions over 3 days. The SARASIN study aimed to compare standard-fractionation to one-daily fractionation prior to transplant in leukemia. Read More

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Is there a link between inflammation and fatigue in multiple sclerosis?

J Inflamm Res 2018 7;11:253-264. Epub 2018 Jun 7.

EA 4391, Excitabilité Nerveuse et Thérapeutique, Université Paris-Est-Créteil, Créteil, France.

Purpose: Among autoimmune diseases of the central nervous system stands multiple sclerosis (MS), which is characterized by demyelination, synaptopathy, and neurodegeneration. MS fatigue can affect up to 90% of patients and be very disabling, with a drastic impact on their quality of life. To date, the evaluation of MS fatigue has relied mainly on subjective scales, and actual therapeutic interventions are challenged by modest efficacy and numerous undesirable effects. Read More

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Reliability of Tidal Volume in Average Volume Assured Pressure Support Mode.

Respir Care 2018 Jun 19. Epub 2018 Jun 19.

Service de Réanimation médicale, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Lyon, France, and Université Lyon 1, Lyon, France, and Institut Mondor de Recherche Biomédicale Institut National de la Santé et de la Recherche Médicale 955, Créteil, France.

Background: Remote monitoring is increasingly used in patients who receive home mechanical ventilation. The average volume assured pressure support mode is a target volume pressure preset mode that delivers a given tidal volume (V) within a range of controlled inspiratory pressures. In a mode such as this, it is important to verify that the V value retrieved from the ventilator SD card is accurate. Read More

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June 2018
1 Read

Transcranial direct current stimulation: A glimmer of hope for multiple sclerosis fatigue?

J Clin Neurosci 2018 Jun 15. Epub 2018 Jun 15.

Service de Physiologie, Explorations Fonctionnelles, Hôpital Henri-Mondor, AP-HP, Creteil, France; EA 4391, Excitabilité Nerveuse et Thérapeutique, Université Paris-Est-Créteil, Creteil, France. Electronic address:

Multiple sclerosis (MS) is a neurological disease of the central nervous system characterized by inflammation, demyelination and neurodegeneration. Throughout the disease process, patients may complain of a panel of sensory, motor, cognitive and behavioral symptoms. Fatigue is a debilitating manifestation of central nervous system diseases with physical, cognitive and psychosocial dimensions. Read More

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Recent advances in deep brain stimulation in psychiatric disorders.

F1000Res 2018 5;7. Epub 2018 Jun 5.

Sorbonne University, UPMC Paris 06 University, INSERM, CNRS, Institut du Cerveau et de la Moelle épinière, Paris, France.

Deep brain stimulation (DBS) has been offered to patients suffering of severe and resistant neuropsychiatric disorders like Obsessive Compulsive Disorder (OCD), Gilles de la Tourette Syndrome (TS) and Major Depression (MDD). Modulation of several targets within the cortico-striato-thalamo-cortical circuits can lead to a decrease of symptom severity in those patients. This review focuses on the recent clinical outcomes in DBS in psychiatric disorders. Read More

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Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder.

Authors:
Céline S Reinbold Andreas J Forstner Julian Hecker Janice M Fullerton Per Hoffmann Liping Hou Urs Heilbronner Franziska Degenhardt Mazda Adli Kazufumi Akiyama Nirmala Akula Raffaella Ardau Bárbara Arias Lena Backlund Antonio Benabarre Susanne Bengesser Abesh K Bhattacharjee Joanna M Biernacka Armin Birner Cynthia Marie-Claire Pablo Cervantes Guo-Bo Chen Hsi-Chung Chen Caterina Chillotti Scott R Clark Francesc Colom David A Cousins Cristiana Cruceanu Piotr M Czerski Alexandre Dayer Bruno Étain Peter Falkai Louise Frisén Sébastien Gard Julie S Garnham Fernando S Goes Paul Grof Oliver Gruber Ryota Hashimoto Joanna Hauser Stefan Herms Stéphane Jamain Esther Jiménez Jean-Pierre Kahn Layla Kassem Sarah Kittel-Schneider Sebastian Kliwicki Barbara König Ichiro Kusumi Nina Lackner Gonzalo Laje Mikael Landén Catharina Lavebratt Marion Leboyer Susan G Leckband Carlos A López Jaramillo Glenda MacQueen Mirko Manchia Lina Martinsson Manuel Mattheisen Michael J McCarthy Susan L McElroy Marina Mitjans Francis M Mondimore Palmiero Monteleone Caroline M Nievergelt Urban Ösby Norio Ozaki Roy H Perlis Andrea Pfennig Daniela Reich-Erkelenz Guy A Rouleau Peter R Schofield K Oliver Schubert Barbara W Schweizer Florian Seemüller Giovanni Severino Tatyana Shekhtman Paul D Shilling Kazutaka Shimoda Christian Simhandl Claire M Slaney Jordan W Smoller Alessio Squassina Thomas J Stamm Pavla Stopkova Sarah K Tighe Alfonso Tortorella Gustavo Turecki Julia Volkert Stephanie H Witt Adam J Wright L Trevor Young Peter P Zandi James B Potash J Raymond DePaulo Michael Bauer Eva Reininghaus Tomáš Novák Jean-Michel Aubry Mario Maj Bernhard T Baune Philip B Mitchell Eduard Vieta Mark A Frye Janusz K Rybakowski Po-Hsiu Kuo Tadafumi Kato Maria Grigoroiu-Serbanescu Andreas Reif Maria Del Zompo Frank Bellivier Martin Schalling Naomi R Wray John R Kelsoe Martin Alda Francis J McMahon Thomas G Schulze Marcella Rietschel Markus M Nöthen Sven Cichon

Front Psychiatry 2018 31;9:207. Epub 2018 May 31.

Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.

Bipolar disorder (BD) is a common, highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. Lithium is the best-established long-term treatment for BD, even though individual response is highly variable. Evidence suggests that some of this variability has a genetic basis. Read More

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May 2018
2 Reads

Progression-Free Survival at 24 Months (PFS24) and Subsequent Outcome For Patients With Diffuse Large B-Cell Lymphoma (DLBCL) Enrolled On Randomized Clinical Trials.

Ann Oncol 2018 Jun 12. Epub 2018 Jun 12.

Department of Hematology, Centre Hospitalier Lyon-Sud, Pierre-Benite, France.

Background: Patients with diffuse large B-cell lymphoma treated with first-line anthracycline based immunochemotherapy and remaining in remission at two years have excellent outcomes. This study assessed overall survival (OS) stratified by progression-free survival at 24 months (PFS24) using individual patient data from patients with DLBCL enrolled in multi-center, international randomized clinical trials as part of the SEAL collaboration.

Patients And Methods: PFS24 was defined as being alive and progression-free 24 months after study entry. Read More

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Mondor disease: Thrombosis of the dorsal vein of the penis.

Urol Case Rep 2018 Jul 5;19:34-35. Epub 2018 May 5.

Urology Department, Av. Empresarios 150, Puerta de Hierro, 45116, Zapopan, Jalisco, Mexico.

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Efficacy of chemotherapy or chemo-anti-PD-1 combination after failed anti-PD-1 therapy for relapsed and refractory Hodgkin lymphoma: A series from Lysa centers.

Am J Hematol 2018 Jun 8. Epub 2018 Jun 8.

Department of Hematology, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.

Anti-PD-1 therapy provides high response rates in Hodgkin lymphoma (HL) patients who have relapsed or are refractory (R/R) to autologous stem cell transplantation (ASCT) and brentuximab vedotin (BV), but median progression free survival (PFS) is only one year. The efficacy of treatment following anti-PD-1 is not well known. We retrospectively investigated the efficacy of salvage therapies for unsatisfactory response to anti-PD-1 therapy, assessed by PET-CT according to the Lugano criteria, in 30 R/R HL patients. Read More

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June 2018
1 Read

The value of electrochemical skin conductance measurement using Sudoscan® in the assessment of patients with familial amyloid polyneuropathy.

Clin Neurophysiol 2018 May 29;129(8):1565-1569. Epub 2018 May 29.

Réseau Amylose Henri-Mondor, Hôpital Henri Mondor, Créteil, France; Université Paris Est Créteil, Faculté de Médecine, GRC Institut de Recherche sur l'Amylose, Créteil, France; Assistance Publique - Hôpitaux de Paris, Hôpital Henri Mondor, Service de Neurologie, Créteil, France.

Objective: To reappraise the value of electrochemical skin conductance (ESC) measurement by Sudoscan® to assess the distal involvement of small autonomic fibers in familial amyloid polyneuropathy (FAP) due to various transthyretin (TTR) mutations.

Methods: ESC was measured at both hands and feet in 126 patients with either Val30Met (n = 65) or non-Val30Met (n = 61) TTR mutation. This series included clinically asymptomatic (n = 21) and paucisymptomatic (n = 30) patients, as well as patients with moderate (n = 37) or advanced (n = 38) TTR-FAP. Read More

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May 2018
1 Read

Are Systemic Manifestations Ascribable to COPD in Smokers? A Structural Equation Modeling Approach.

Sci Rep 2018 Jun 5;8(1):8569. Epub 2018 Jun 5.

APHP, Hôpital Henri Mondor, Département de Santé Publique, F-94010, Créteil, France.

Whether the systemic manifestations observed in Chronic Obstructive Pulmonary Disease (COPD) are ascribable to lung dysfunction or direct effects of smoking is in debate. Structural Equations Modeling (SEM), a causal-oriented statistical approach, could help unraveling the pathways involved, by enabling estimation of direct and indirect associations between variables. The objectives of the study was to investigate the relative impact of smoking and COPD on systemic manifestations, inflammation and telomere length. Read More

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June 2018
2 Reads

HLA genetics in bipolar disorder.

Acta Psychiatr Scand 2018 Jun 4. Epub 2018 Jun 4.

INSERM, U955, Translational Psychiatry, Paris-East University, School of Medicine, AP-HP, DHU PePSY, Pole of Psychiatry, Henri Mondor University Hospital, Créteil, France.

Objective: Bipolar Disorder (BD) is characterized by deregulated adaptive immune processes. Recent genome-wide association studies (GWAS) implicate the major histocompatibility complex (MHC) region in BD. The present study investigates the potential influence of variations in human leukocyte antigen (HLA) on BD risk and/or clinical presentations. Read More

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June 2018
1 Read

Polycystic kidney features of the renal pathology in glycogen storage disease type I: possible evolution to renal neoplasia.

J Inherit Metab Dis 2018 Jun 4. Epub 2018 Jun 4.

Institut National de la Santé et de la Recherche by Inserm, U1213, 69008, Lyon, France.

Glycogen storage disease type I (GSDI) is a rare genetic pathology characterized by glucose-6 phosphatase (G6Pase) deficiency, translating in hypoglycemia during short fasts. Besides metabolic perturbations, GSDI patients develop long-term complications, especially chronic kidney disease (CKD). In GSDI patients, CKD is characterized by an accumulation of glycogen and lipids in kidneys, leading to a gradual decline in renal function. Read More

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June 2018
1 Read

Stereotactic radiation therapy in the strategy of treatment of metastatic renal cell carcinoma: A study of the Getug group.

Eur J Cancer 2018 Jul 1;98:38-47. Epub 2018 Jun 1.

Centre François Baclesse, Department of Clinical Research, 14000, Caen, France; Centre François Baclesse, Department of Clinical Oncology, 14000, Caen, France.

Background: Renal cell carcinoma (RCC) is usually considered radioresistant, but stereotactic radiation therapy (SRT) may increase local disease control. This study aimed to assess the benefit of SRT in the management of metastatic RCC patients.

Methods: Data of all RCC patients who received SRT between 2008 and 2015 with curative intent were retrospectively collected in six French referral centres. Read More

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July 2018
3 Reads

Predictors of surgical outcomes and survival in rectal cancer patients undergoing laparoscopic total mesorectal excision after neoadjuvant chemoradiation therapy: the interest of pelvimetry and restaging magnetic resonance imaging studies.

Oncotarget 2018 May 18;9(38):25315-25331. Epub 2018 May 18.

Department of Radiology, Henri Mondor Hospital, AP-HP, University of Paris Est, UPEC, Créteil, France.

Background: Locally advanced rectal cancer (LARC) requires a multimodal therapy tailored to the patient and tumor characteristics. Pretreatment magnetic resonance imaging (MRI) is necessary to stage the primary tumor, while restaging MRI, which is not systematically performed, may be of interest to identify poor responders to neoadjuvant chemoradiation therapy (NCRT), and redefine therapeutic approach. The study group aimed to investigate the role and accuracy of pretreatment (including pelvimetry) and restaging MRIs in predicting surgical difficulties and surgical outcomes in LARC therapy. Read More

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Low-dose ritonavir-boosted darunavir in virologically suppressed HIV-1-infected adults: an open-label trial (ANRS 165 Darulight).

J Antimicrob Chemother 2018 Jun 1. Epub 2018 Jun 1.

University of Paris Diderot, Sorbonne Paris University, Paris, France.

Objectives: To assess whether low-dose ritonavir-boosted darunavir (darunavir/r) in combination with two NRTIs could maintain virological suppression in patients on a standard regimen of darunavir/r + two NRTIs.

Design: A multicentre, Phase II, non-comparative, single-arm, open-label study.

Setting: Tertiary care hospitals in France. Read More

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June 2018
3 Reads

Robotic Versus Laparoscopic Colorectal Cancer Surgery in Elderly Patients: A Propensity Score Match Analysis.

J Laparoendosc Adv Surg Tech A 2018 May 31. Epub 2018 May 31.

1 Department of Digestive, Hepato-Pancreato-Biliary Surgery, and Liver Transplantation, Henri Mondor Hospital , AP-HP, Créteil, France.

Background: Minimally invasive surgery in elderly patients with colorectal cancer remains controversial. The study aimed to compare the operative, postoperative, and oncologic outcomes of robotic (robotic colorectal resection surgery [RCRS]) versus laparoscopic colorectal resection surgery (LCRS) in elderly patients with colorectal cancer.

Methods: Propensity score matching (PSM) was used to compare patients aged 70 years and more undergoing elective RCRS or LCRS for colorectal cancer between 2010 and 2017. Read More

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May 2018
1 Read

History of concentrated or expanded mesenchymal stem cells for hip osteonecrosis: is there a target number for osteonecrosis repair?

Int Orthop 2018 May 24. Epub 2018 May 24.

Hôpital Henri Mondor, 94010, Creteil, France.

Purpose: Despite multiple possible treatments, the risk of collapse remains the main problem of osteonecrosis. Heart failure (HF). In an effort to address the reverse this issue, curative strategies with regenerative medicine are increasingly being considered. Read More

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May 2018
4 Reads

Persistence of treatment with biologics for patients with psoriasis: a real-world analysis of 16,545 biologic-naïve patients from the French national health insurance database (SNIIRAM).

Br J Dermatol 2018 May 23. Epub 2018 May 23.

Département d'études en santé publique, Direction de la stratégie, des études et des statistiques, Caisse Nationale d'Assurance Maladie des Travailleurs Salariés (CNAM), Paris, F-75020, France.

Background: Long-term clinical effectiveness of biologics in psoriasis is needed.

Objectives: We aimed to assess the long-term persistence of biologics used to treat psoriasis in a real-life setting.

Methods: All adults with psoriasis having been registered in the French national health insurance database (SNIIRAM) between 2008 and 2016 were eligible for inclusion. Read More

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May 2018
1 Read

Increased Severity and Epidermal Alterations in Persistent versus Evanescent Skin lesions in Adult Onset Still's disease.

J Am Acad Dermatol 2018 May 19. Epub 2018 May 19.

Dermatology Department, Hôpital Saint-Louis, AP-HP, F-75010, Paris, France; Paris VII Sorbonne Paris Cité University, F-75013, Paris, France; INSERM UMRS-976, Hôpital Saint-Louis, F-75010, Paris, France. Electronic address:

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Mondor's Disease: A Review of the Literature.

Intern Med 2018 May 18. Epub 2018 May 18.

Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Japan.

Mondor's disease (MD) is a rare disease that manifests with a palpable cord-like induration on the body surface. In general, MD is a self-limited, benign thrombophlebitis that resolves in four to eight weeks without any specific treatment. Cases of MD can be roughly categorized into three different groups based on the site of the lesion as follows: original MD of the anterolateral thoracoabdominal wall, penile MD with dorsum and dorsolateral aspects of the penis, and axillary web syndrome with mid-upper arm after axillary surgery. Read More

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Geriatric analysis from PRODIGE 20 randomized phase II trial evaluating bevacizumab + chemotherapy versus chemotherapy alone in older patients with untreated metastatic colorectal cancer.

Eur J Cancer 2018 Jul 16;97:16-24. Epub 2018 May 16.

Geriatric Department, CHU Henri Mondor, APHP, Créteil, France.

Background: Older patients have frailty characteristics that impair the transposition of treatment results found in younger patients. Predictive factors are needed to help with treatment choices for older patients. The PRODIGE 20 study is a randomized phase II study that evaluated chemotherapy associated with bevacizumab (BEV) or not (CT) in patients aged 75 years or older. Read More

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[How I do…for the surgical management of gestational gigantomastia].

Gynecol Obstet Fertil Senol 2018 06;46(6):550-554

Service de chirurgie sénologique, centre Oscar Lambret, 3, rue Frédéric Combemale, 59000 Lille, France; Department of Maxillofacial and Plastic & Reconstructive Surgery, Henri Mondor Hospital, 51, avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France. Electronic address:

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Optimising experimental research in respiratory diseases: an ERS statement.

Eur Respir J 2018 May 17;51(5). Epub 2018 May 17.

Dept of Medicine, Firestone Institute for Respiratory Health at St Joseph's Health Care MDCL 4011, McMaster University, Hamilton, ON, Canada.

Experimental models are critical for the understanding of lung health and disease and are indispensable for drug development. However, the pathogenetic and clinical relevance of the models is often unclear. Further, the use of animals in biomedical research is controversial from an ethical perspective. Read More

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May 2018
8 Reads

How can we expand active surveillance criteria in patients with low- and intermediate-risk prostate cancer without increasing the risk of misclassification? Development of a novel risk calculator.

BJU Int 2018 May 17. Epub 2018 May 17.

Department of Urology, Henri Mondor Hospital, Assistance-Publique Hopitaux de Paris, Creteil, France.

Objective: To develop a novel tool to increase the number of patients with prostate cancer eligible for active surveillance (AS) without increasing the risk of unfavourable pathological features (i.e., misclassification) at radical prostatectomy (RP). Read More

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May 2018
5 Reads

Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease.

Hum Mol Genet 2018 May 16. Epub 2018 May 16.

Laboratory of Genetics in Ophthalmology (LGO), INSERM UMR1163, Institute of Genetics Diseases, Imagine and Paris Descartes University, 75015 Paris, France.

CEP290 mutations cause a spectrum of ciliopathies from Leber congenital amaurosis type 10 (LCA10) to embryo-lethal Meckel syndrome (MKS). Using panel-based molecular diagnosis testing for inherited retinal diseases, we identified two individuals with some preserved vision despite biallelism for presumably truncating CEP290 mutations. The first one carried a homozygous 1 base-pair deletion in exon 17, introducing a premature termination codon (PTC) in exon 18 (c. Read More

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May 2018
2 Reads

Increase In Il-31 Serum Levels Is Associated With Reduced Structural Damage In Early Axial Spondyloarthritis.

Sci Rep 2018 May 16;8(1):7731. Epub 2018 May 16.

Paris Descartes University, Department of Rheumatology - Hôpital Cochin. Assistance Publique - Hôpitaux de Paris, EULAR center of excellence, Paris, France.

In spondyloarthritis, little is known about the relation between circulating cytokines and patient phenotype. We have quantified serum levels of T helper type 1 cell (Th1), Th2 and Th17 cytokines in patients with recent-onset axial spondyloarthritis (AxSpA) from the DESIR cohort, a prospective, multicenter French cohort consisting of 708 patients with recent-onset inflammatory back pain (duration >3 months but <3 years) suggestive of AxSpA. Serum levels of Th1, Th2, and Th17 cytokines were assessed at baseline in patients from the DESIR cohort fulfilling the ASAS criteria (ASAS+) and were compared with age- and sex-matched healthy controls. Read More

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May 2018
16 Reads

Delisting HCV-infected liver transplant candidates who improved after viral eradication: Outcome 2 years after delisting.

Liver Int 2018 May 11. Epub 2018 May 11.

Gastroenterology and Hepatology Unit, Liver Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.

Backgrounds & Aims: Treating patients with decompensated cirrhosis with direct-acting antiviral (DAA) therapy while on the waiting list for liver transplantation results in substantial improvement of liver function allowing 1 in 4 patients to be removed from the waiting list or delisted, as reported in a previous study promoted by the European Liver and Intestine Transplant Association (ELITA). The aim of this study was to report on clinical outcomes of delisted patients, including mortality risk, hepatocellular carcinoma development and clinical decompensation requiring relisting.

Methods: One hundred and forty-two HCV-positive patients on the liver transplant waiting list for decompensated cirrhosis, negative for hepatocellular carcinoma, between February 2014 and June 2015 were treated with DAA therapy and were prospectively followed up. Read More

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A novel in vivo porcine model of intervertebral disc degeneration induced by cryoinjury.

Int Orthop 2018 May 10. Epub 2018 May 10.

Université Paris-Est-Créteil (UPEC), Laboratoire de bio-ingénierie cellulaire, tissulaire et sanguine à visée thérapeutique (BCTSVT), INSERM/IMRB-U955, équipe n°10, groupe 5, Créteil, France.

Purpose: Degenerative disc disease involves sequential events that lead to the loss of cells, a decrease in disc matrix production, disc dehydration, and alteration of its biomechanical properties. The aim of this study was to determine whether cryoinjury of the nucleus pulposus performed through endplate perforation contributes to disc degeneration and to compare this technique with standard methods.

Method: Under general anesthesia, the lumbar discs of six pigs were exposed and randomly submitted to needle puncture of the annulus fibrosus (NeP), isolated endplate injury (EP), or cryoinjury using a 2. Read More

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Cell therapy versus simultaneous contralateral decompression in symptomatic corticosteroid osteonecrosis: a thirty year follow-up prospective randomized study of one hundred and twenty five adult patients.

Int Orthop 2018 May 9. Epub 2018 May 9.

Hôpital Henri Mondor, 94010, Creteil, France.

Purpose: Symptomatic osteonecrosis related to corticosteroids has a high risk of progression to collapse in absence of treatment. The purposes of this study were to evaluate the results of autologous bone marrow grafting of the symptomatic hip in adult patients with osteonecrosis and to compare the results with core decompression alone in the contralateral symptomatic hip.

Materials And Methods: A total of 125 consecutive patients (78 males and 47 females) with bilateral osteonecrosis (ON) and who had both hips symptomatic and at the same stage on each side (stage I or II) were included in this study from 1988 to 1998. Read More

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May 2018
1 Read

Safety of Intravenous Immunoglobulin (Tegeline®), Administered at Home in Patients with Autoimmune Disease: Results of a French Study.

Biomed Res Int 2018 15;2018:8147251. Epub 2018 Mar 15.

International Affairs Scientific Unit, LFB Biomedicaments, Les Ulis, France.

The efficacy of intravenous immunoglobulins (IVIg) in patients with autoimmune diseases (AID) has been known for several decades. Majority of these patients received IVIg in hospital. A retrospective study was conducted in 22 centers in France to evaluate the feasibility of the administration of Tegeline, an IVIg from LFB Biomedicaments, and assess its safety at home, compared to in hospital, in patients with AID. Read More

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HLA class I and II diversity contributes to the etiologic heterogeneity of non-Hodgkin lymphoma subtypes.

Cancer Res 2018 May 7. Epub 2018 May 7.

Emory University.

A growing number of loci within the human leukocyte antigen (HLA) region have been implicated in non-Hodgkin lymphoma (NHL) etiology. Here, we test a complementary hypothesis of "heterozygote advantage" regarding the role of HLA and NHL, whereby HLA diversity is beneficial and homozygous HLA loci are associated with increased disease risk. HLA alleles at class I and II loci were imputed from genome-wide association studies (GWAS) using SNP2HLA for: 3,617 diffuse large B-cell lymphomas (DLBCL), 2,686 follicular lymphomas (FL), 2,878 chronic lymphocytic leukemia/small lymphocytic lymphomas (CLL/SLL), 741 marginal zone lymphomas (MZL), and 8,753 controls of European descent. Read More

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May 2018
3 Reads

Fornical Closed-Loop Stimulation for Alzheimer's Disease.

Trends Neurosci 2018 Jul 4;41(7):418-428. Epub 2018 May 4.

Krembil Research Institute, University Health Network, Toronto, ON, Canada; Division of Neurosurgery, Department of Surgery, Krembil Neuroscience Centre, University Health Network, University of Toronto, Toronto, ON, Canada.

Pharmacological neuromodulation strategies have shown limited efficacy in treating memory deficits related to Alzheimer's disease (AD). Despite encouraging results from a few preclinical studies, clinical trials investigating open-loop deep brain stimulation (DBS) for AD have not been successful. Recent refinements in understanding the various phases of memory processes, animal studies investigating phase-specific modulation of hippocampal activity during memorization, and clinical studies using closed-loop DBS strategies to treat patients with movement disorders, all point to the need to investigate closed-loop fornical DBS strategies to better understand memory dynamics and potentially treat memory deficits in AD preclinical models. Read More

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July 2018
2 Reads

Compliance With Hepatocellular Carcinoma Surveillance Guidelines Associated With Increased Lead-time Adjusted Survival of Patients With Compensated Viral Cirrhosis.

Gastroenterology 2018 May 2. Epub 2018 May 2.

AP-HP, Hôpital Jean Verdier, Service d'Hépatologie, Bondy; Inserm UMR-1162, "Functional Genomics of Solid Tumors", Université Paris Descartes, Université Paris Diderot, Université Paris 13, Labex Oncoimmunology, Equipe labellisée Ligue contre le Cancer, Paris.

Background And Aims: Semi-annual surveillance for hepatocellular carcinoma (HCC) is recommended for patients with cirrhosis. We aimed to determine how compliance with HCC surveillance guidelines affects survival times of patients with hepatitis C virus (HCV)- or HBV-associated compensated cirrhosis who developed HCC.

Methods: We collected data from the prospective ANRS CO12 CirVir study, from March 2006 through June 2012, on 1671 patients with biopsy-proven viral cirrhosis and no previous liver complications who were undergoing surveillance for HCC at 35 centers in France. Read More

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Local and Regional Breast Cancer Recurrences: Salvage Therapy Options in the New Era of Molecular Subtypes.

Front Oncol 2018 17;8:112. Epub 2018 Apr 17.

Sorbonne University, INSERM U938, APHP Tenon, Breast Cancer Expert Center, Paris, France.

Isolated local or regional recurrence of breast cancer (BC) leads to an increased risk of metastases and decreased survival. Ipsilateral breast recurrence can occur at the initial tumor bed or in another quadrant of the breast. Depending on tumor patterns and molecular subtypes, the risk and time to onset of metastatic recurrence differs. Read More

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April 2018
2 Reads

Involvement of neural crest and paraxial mesoderm in oral mucosal development and healing.

Biomaterials 2018 Jul 21;172:41-53. Epub 2018 Apr 21.

Cordeliers Research Center, Laboratory of Molecular Oral Physiopathology, INSERM UMRS 1138, 15 rue de l'école de médecine, 75006 Paris, France; Paris-Descartes and Paris-Diderot Universities, UFR Odontology, 75006 Paris, France; Reference Center for Dental Rare Disease, Rothschild Hospital, 75012 Paris, France. Electronic address:

Tissue engineering therapies using adult stem cells derived from neural crest have sought accessible tissue sources of these cells because of their potential pluripotency. In this study, the gingiva and oral mucosa and their associated stem cells were investigated. Biopsies of these tissues produce neither scarring nor functional problems and are relatively painless, and fresh tissue can be obtained readily during different chairside dental procedures. Read More

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July 2018
1 Read

Burden of severe spondyloarthritis in France: A nationwide assessment of prevalence, associated comorbidities and cost.

Joint Bone Spine 2018 Apr 27. Epub 2018 Apr 27.

Rheumatology department, Ambroise-Paré hospital, AP-HP, 92100 Boulogne, France; UMR 1173 Inserm, university of Versailles-Saint-Quentin-en-Yvelines, 78180 Montigny-le-Bretonneux, France; Laboratoire d'Excellence Inflamex, université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France.

Objectives: To estimate the number of patients with severe spondyloarthritis (SpA) in France, describe their comorbidities and document and value their healthcare resource consumption.

Methods: Data were retrieved from an insurance claims database covering a 1/97 random sample of the French population. All patients benefiting from full insurance coverage ("ALD") for severe SpA in 2012 (including cases with structural damage and/or frequent flares) were identified, together with a control group frequency-matched by age and gender. Read More

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April 2018
2 Reads

High immunogenicity of red blood cell antigens restricted to the population of African descent in a cohort of sickle cell disease patients.

Transfusion 2018 Apr 29. Epub 2018 Apr 29.

Etablissement Français du Sang (EFS)-Ile de France, Créteil.

Background: Sickle cell disease (SCD) patients undergo multiple red blood cell (RBC) transfusions and are regularly exposed to low-prevalence (LP) antigens specific to individuals of African descent. This study evaluated the prevalence of antibodies against LP antigens in SCD patients and the need to identify these antibodies in everyday practice.

Study Design And Methods: Plasma from 211 SCD patients was tested with RBCs expressing the following LP antigens: RH10 (V), RH20 (VS), RH23 (D ), RH30 (Go ), KEL6 (Js ), and MNS6 (He). Read More

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April 2018
4 Reads

[Current insights about recurrence of glomerular diseases after renal transplantation].

Nephrol Ther 2018 May 26;14(3):179-188. Epub 2018 Apr 26.

Service de néphrologie et transplantation, hôpital Henri-Mondor, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France; Institut francilien de recherche en néphrologie et transplantation (IFRNT), université Paris Est-Créteil (Upec), avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France. Electronic address:

Recurrence of glomerular disease after renal transplantation is a frequent cause of graft loss. Incidence, risk factors and outcome of recurrence are widely due to the underlying glomerular disease. Graft biopsy analysis is required to confirm the definitive diagnosis of recurrence and to start an appropriate therapy that, in some cases, remains challenging to prevent graft failure. Read More

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Elevated total Serum IgE in vitiligo might be protective for other autoimmune diseases.

Br J Dermatol 2018 Apr 28. Epub 2018 Apr 28.

Department of Dermatology, Bordeaux University Hospitals, Bordeaux, France.

Vitiligo is a chronic inflammatory skin depigmenting disorder that is often associated with other autoimmune disease such as thyroiditis. Moreover, there is growing evidence that vitiligo is also associated with atopy, a genetic tendency to develop allergic hypersensitivity reactions, with production of immunoglobulin E (IgE). Indeed, the largest study conducted in the US population found a higher prevalence of atopic diseases in vitiligo. Read More

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Integrated Care for the Use of Direct-acting Antivirals in Patients With Chronic Hepatitis C and Substance Use Disorder.

J Addict Med 2018 Apr 26. Epub 2018 Apr 26.

Service d'addictologie, Hôpitaux Universitaires Henri Mondor, APHP, Université Paris-Est, Créteil, France (J-BT); Service d'hépato-gastroentérologie, Hôpital Intercommunal, Créteil, France (CB); Service de pharmacie, Hôpitaux Universitaires Henri Mondor, APHP, Université Paris-Est, Créteil, France (HC); Centre Epice, Créteil, France (DC); CSAPA EGO, Association Aurore, Paris, France (AB); Centre Nova Dona, Paris, France (MB); Service d'hépatologie, Hôpital Henri Mondor, APHP, Université Paris-Est, Créteil, France (MF, FR-T, CH); Service de pharmacie, Hôpital Henri Mondor, APHP, Université Paris-Est, Créteil, France (WK-M); Service de pharmacie, Hôpital Intercommunal, Créteil, France (RC); and INSERM U955, Créteil, France (CH).

Objectives: Since little is currently known about predictors of response to direct-acting antiviral agents (DAAs) in people who inject drugs, we undertook an analysis of patients attending a hepatitis clinic with addiction services (outpatient clinics and inpatient services) to examine the outcomes associated with the treatment of difficult-to-manage patients with substance use. Our experience was based on integrated care.

Method: A retrospective analysis was undertaken of 50 patients with hepatitis C virus (HCV) and a history of addiction who received treatment with DAAs, according to European guidelines. Read More

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April 2018
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Comparison of individually tailored versus fixed-schedule rituximab regimen to maintain ANCA-associated vasculitis remission: results of a multicentre, randomised controlled, phase III trial (MAINRITSAN2).

Ann Rheum Dis 2018 Apr 25. Epub 2018 Apr 25.

Internal Medicine, Referral Center for Rare Systemic and Autoimmune Diseases: Vasculitis and Scleroderma, Cochin Hospital, Paris Descartes University, Paris, France.

Objective: To compare individually tailored, based on trimestrial biological parameter monitoring, to fixed-schedule rituximab reinfusion for remission maintenance of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAVs).

Methods: Patients with newly diagnosed or relapsing granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) in complete remission after induction therapy were included in an open-label, multicentre, randomised controlled trial. All tailored-arm patients received a 500 mg rituximab infusion at randomisation, with rituximab reinfusion only when CD19+B lymphocytes or ANCA had reappeared or ANCA titre rose markedly based on trimestrial testing until month 18. Read More

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April 2018
7 Reads

Impaired TGF-β signaling in patients with active systemic lupus erythematosus is associated with an overexpression of IL-22.

Cytokine 2018 Aug 21;108:182-189. Epub 2018 Apr 21.

Laboratory of Transmission, Control and Immunobiology of Infections, LR11IPT02, Institut Pasteur de Tunis, 1002 Tunis, Tunisia; Faculté de Médecine de Tunis, Université Tunis El Manar, Tunis, Tunisia. Electronic address:

The mechanisms leading to the disruption of self-tolerance in systemic lupus erythematosus (SLE) remain elusive. Herein, we aimed to decipher the molecular basis of the impaired response of mononuclear cells to TGF-β1. The Smad3-pathway was explored on CD3+ lymphocytes in either active or non active SLE patients. Read More

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August 2018
2 Reads

Diagnosis-to-Treatment Interval Is an Important Clinical Factor in Newly Diagnosed Diffuse Large B-Cell Lymphoma and Has Implication for Bias in Clinical Trials.

J Clin Oncol 2018 Jun 19;36(16):1603-1610. Epub 2018 Apr 19.

Matthew J. Maurer, Thomas M. Habermann, Carrie A. Thompson, Cristine Allmer, Patrick B. Johnston, Ivana N. Micallef, David J. Inwards, William R. Macon, Andrew L. Feldman, Susan L. Slager, Stephen M. Ansell, James R. Cerhan, Thomas E. Witzig, and Grzegorz S. Nowakowski, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Gilles A. Salles, Université Claude Bernard, Lyon; Jean-Philippe Jais, Richard Delarue, Thierry J. Molina, Hopital Necker, Paris; Corinne Haioun, Groupe Hospitalier Mondor, Créteil; Frederic Peyrade, Centre Antoine Lacassagne, Nice; Olivier Fitoussi, Polyclinique Bordeaux Nord-Aquitaine, Bordeaux; Hervé Tilly, Centre de lutte Contre le Cancer Henri Becquerel, Rouen, France; Brian K. Link, Umar Farooq, Sergei Syrbu, and George J. Weiner, University of Iowa, Iowa City, IA; and Nicolas Ketterer, Clinique Bois-Cerf, Lausanne, Switzerland.

Purpose Selection bias in clinical trials has consequences for scientific validity and applicability of study results to the general population. There is concern that patients with clinically aggressive disease may not have enrolled in recent diffuse large B-cell lymphoma (DLBCL) trials due to the consent process and the inability to delay therapy for eligibility evaluation. We have examined the diagnosis-to-treatment interval (DTI) and its association with clinical factors and outcome in a clinic-based observational cohort of patients with DLBCL from the United States. Read More

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Efficacy of transcranial direct current stimulation combined with cognitive training in the treatment of apathy in patients with Alzheimer's disease: study protocol for a randomized trial.

Rev Recent Clin Trials 2018 04 16. Epub 2018 Apr 16.

Service de geriatrie, CHU hopital Bellier, 44000 Nantes. France.

Background: Apathy, commonly defined as loss of motivation, is a symptom frequently encountered in Alzheimer's disease (AD). The treatment of apathy remains challenging in the absence of any truly effective medications. Transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) can improve cognitive disorders, but do not appear to improve apathy. Read More

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Effectiveness and safety of anti-TNF therapy for inflammatory bowel disease in liver transplant recipients for primary sclerosing cholangitis: A nationwide case series.

Dig Liver Dis 2018 Mar 13. Epub 2018 Mar 13.

University Hospital of St Eloi, Department of Hepatology and Gastroenterology, Montpellier, France.

Background: There is a lack of consensus regarding the treatment of inflammatory bowel disease (IBD) after liver transplantation (LT) forprimary sclerosing cholangitis (PSC).

Aim: To investigate the safety and effectiveness of anti-TNF therapy in patients with IBD after a LT for PSC.

Methods: We reviewed the medical files of all of the IBD patients who underwent a LT for PSC and who were treated with anti-TNF therapy at 23 French liver transplantation centers between 1989 and 2012. Read More

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March 2018
3 Reads

[Radiation therapy in patients with inflammatory bowel disease. A review].

Bull Cancer 2018 May 10;105(5):517-522. Epub 2018 Apr 10.

Université Paris Est Créteil (UPEC), AP-HP, hôpitaux universitaires Henri-Mondor, service d'oncologie-radiothérapie & centre sein Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France; Inserm unité 955 EQ 07, 94010 Créteil, France. Electronic address:

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, are multifactorial diseases characterized by a chronic intestinal inflammation. Abdominal and pelvic irradiation can result in acute or chronic digestive toxicity. A few old studies on small population samples have suggested an increase of gastro-intestinal toxicities in patients with IBD in case of irradiation. Read More

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May 2018
1 Read

Prognostic value of viral eradication for major adverse cardiovascular events in hepatitis C cirrhotic patients.

Am Heart J 2018 Apr 7;198:4-17. Epub 2017 Nov 7.

AP-HP, Hôpital Henri Mondor, Unité de Recherche Clinique (URC-Mondor), and Université Paris-Est, A-TVB DHU, CEpiA (Clinical Epidemiology and Aging) Unit EA4393, UPEC, Créteil.

Background: The objective was to examine the role of a sustained virological response (SVR) on major adverse cardiovascular events (MACEs) in patients with compensated hepatitis C virus (HCV) cirrhosis.

Methods: Patients with the following criteria were enrolled in 35 French centers: (1) biopsy-proven HCV cirrhosis; (2) Child-Pugh A; (3) positive viremia; and (4) no prior liver complication, and then prospectively followed. All patients received HCV treatment after inclusion. Read More

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April 2018
4 Reads

Diagnostic and management of life-threatening Adult-Onset Still Disease: a French nationwide multicenter study and systematic literature review.

Crit Care 2018 Apr 11;22(1):88. Epub 2018 Apr 11.

Service de Médecine Interne, PHU3, CHU Hôtel-Dieu, 44093, Nantes, France.

Background: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disorder. A few patients develop organ complications that can be life-threatening. Our objectives were to describe the disease course and phenotype of life-threatening AOSD, including response to therapy and long-term outcome. Read More

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April 2018
3 Reads

Case for diagnosis. Atypical genital lesion.

An Bras Dermatol 2018 Jan-Feb;93(1):143-144

Service of Sexually Transmitted Infection - Fundação Alfredo da Matta (FUAM) - Manaus (AM), Brazil.

We present a case of a penile lesion with a clinical appearance similar to Mondor penile disease (thrombosis of the dorsal vein of the penis) or penile sclerosing lymphangitis. Laboratory evaluation, however, showed a solid lesion, with no vascular component to Doppler ultrasonography and no treponema to immunohistochemistry. Histological and serological tests were compatible with secondary syphilis. Read More

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April 2018
4 Reads