9,862 results match your criteria Mondor Disease


Simultaneous Robotic Total Mesorectal Excision and Radical Prostatectomy and Enlarged Iliac Lymphadenectomy for Synchronous Adenocarcinomas - a Video Vignette.

Colorectal Dis 2018 Dec 13. Epub 2018 Dec 13.

Unit of Digestive of Digestive Surgery, Henri Mondor Hospital, AP-HP, University of Paris Est, UPEC, Créteil, France.

Synchronous, locally-advanced, low rectal cancer and prostate adenocarcinoma together represent a rare and challenging situation for both colorectal surgeons and urologists. The simultaneous resection of both adenocarcinomas after long-course chemoradiation therapy may be associated with a potentially increased postoperative morbidity [1, 2]. On the other hand, simultaneous resection minimises the complications which might be expected if the two procedures are scheduled sequentially. Read More

View Article
December 2018

Elevated adiponectin and sTNFRII serum levels can predict progression to hepatocellular carcinoma in patients with compensated HCV1 cirrhosis.

Eur Cytokine Netw 2018 Sep;29(3):112-120

AP-HP, hôpital Jean-Verdier, service d'hépatologie, Bondy, France, Inserm UMR_S 1162, « Génomique fonctionnelle des tumeurs solides », 75005 Paris, France, Université Paris 13, Sorbonne Paris-Cité, « Équipe labellisée Ligue contre le cancer », 93206 Saint-Denis, France.

An obesity-related altered adipose tissue secretion is suggested as a risk factor for hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) cirrhosis. However, no prospective study has yet examined the predictive value of circulating adipokines and immuno-inflammatory biomarkers regarding this risk. This was a case-control study nested in a prospective French national cohort of HCV-infected patients with biopsy-proven compensated cirrhosis. Read More

View Article
September 2018

Laparoscopic Roux-En-Y Fistulo-Jejunostomy, a Preferred Technique after Failure of Endoscopic and Radiologic Management of Fistula Post Sleeve Gastrectomy.

Obes Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Digestive Surgery, Archet II Hospital, University of Nice-Sophia-Antipolis, 151 Route de Saint-Antoine, 06200, Nice, France.

Background: Laparoscopic sleeve gastrectomy represents the most performed bariatric procedure in France. Staple line leak is the major short-term complication of the procedure. Patients with persistent fistula after sleeve gastrectomy, after failure of endoscopic and radiological treatment, are candidates for salvage surgery. Read More

View Article
December 2018

Stroke in the Arab World: A bibliometric analysis of research activity (2002-2016).

eNeurologicalSci 2018 Dec 22;13:40-45. Epub 2018 Nov 22.

Department of Neurology, Henri-Mondor Hospital, UPEC, Assistance Publique-Hopitaux de Paris, Creteil, France.

Background: The Arab world has an increasing prevalence of strokes, a leading cause of death in this part of the world.

Aims: The aim of this article is to quantify the stroke research activity in the Arab countries over the past 15 years taking into consideration the population, GDP, and DALY of each country.

Methods: A PubMed search was conducted to find stroke research articles published from the Arab countries between 2002 and 2016 (inclusive). Read More

View Article
December 2018

Higher frequency of dipeptidyl peptidase IV inhibitor intake in bullous pemphigoid patients than in the French general population.

J Invest Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, Rouen University Hospital and INSERM U1234, Centre de référence des maladies bulleuses autoimmunes, Normandie University, Rouen.

Dipeptidyl-peptidase-IV-inhibitors have been suspected to induce bullous pemphigoid (BP). The objective of this study was to compare the observed frequency of gliptin intake in a large sample of 1787 BP patients diagnosed between 2012 and 2015 in France, with the expected frequency after indirect age standardization on 225412 individuals extracted from the database of the National Healthcare Insurance Agency. The secondary objective was to assess the clinical characteristics and the course of gliptin-associated BP depending on whether gliptin was continued or stopped. Read More

View Article
December 2018

Interactions of and in an Mixed Biofilm Model: Does the Strain Matter?

Front Microbiol 2018 27;9:2850. Epub 2018 Nov 27.

EA 7380 Dynamyc, Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est Créteil, Créteil, France.

(Af) and (Sm) are pathogenic microorganisms, which coexist in the respiratory tract of cystic fibrosis (CF) patients. We recently developed an model of mixed biofilm associating Af ATCC 13073-GFP (Af13073) and Sm ATCC 13637 (Sm13637) and described an antibiosis effect. The present study aim was to assess the antibiosis of Sm on Af using different strains and to analyze the potential synergistic virulence of these strains in an model. Read More

View Article
November 2018

Aspergillus pseudodeflectus: a new human pathogen in liver transplant patients.

BMC Infect Dis 2018 Dec 12;18(1):648. Epub 2018 Dec 12.

Unité de Parasitologie-Mycologie, Département de Virologie, Bactériologie-Hygiène, Parasitologie-Mycologie, DHU VIC, CHU Henri Mondor, AP-HP, Créteil, France.

Background: Liver transplant recipients are at high risk of developing invasive aspergillosis and in particular by Aspergillus fumigatus which is the most commonly encountered species in this population. Other non-fumigatus Aspergillus species with reduced susceptibility to antifungal drugs can also be involved. Accurate identification associated to antifungal susceptibility testing is essential for therapy adjustment. Read More

View Article
December 2018

[Physicians and advance directives in geriatric setting].

Soins Gerontol 2018 Jul - Aug;23(132):34-39

Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Henri-Mondor, Pôle gériatrique de l'Essonne, Site Dupuytren, 1 avenue Eugène-Delacroix, 91210 Draveil, France; Université Paris-Est Créteil, DHU A-TVB, IMRB-EA 7376 CEpiA (Clinical Epidemiology and Ageing), 51 avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France. Electronic address:

Advance directives (AD) are not sufficiently applied in geriatric setting despite their widespread dissemination since the publication of Claeys-Leonetti law. The aim of this study was to analyze geriatricians' knowledge of the concept of AD and to evaluate their practices in the process of patient information and AD collection. Read More

View Article
December 2018

Postimplant biological aortic prosthesis degeneration: challenges in transcatheter valve implants.

Eur J Cardiothorac Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardio-Thoracic Surgery, Maastricht University Medical Centre, Maastricht, Netherlands.

Surgical aortic valve replacement (SAVR) is highly effective and can be achieved with relatively low risk in patients with severe aortic stenosis. Bioprostheses have been used most frequently during the past 60 years. However, the function of biological valves usually declines after 10-15 years from implant when structural valve degeneration occurs often mandating a reoperation once valve dysfunction becomes haemodynamically significant. Read More

View Article
December 2018
2 Reads
3.304 Impact Factor

Gray-zone Lymphoma Between cHL and Large B-Cell Lymphoma: A Histopathologic Series From the LYSA.

Am J Surg Pathol 2018 Dec 11. Epub 2018 Dec 11.

INSERM1052, CNRS 5286, Lyon-Sud Charles Mérieux Lyon-1 Faculty, Claude Bernard University.

Gray-zone lymphoma (GZL) with features intermediate between classic Hodgkin lymphoma (cHL) and large B-cell lymphoma (LBCL) was introduced as a provisional entity into the World Health Organization classification in 2008. However, as diagnostic criteria are imprecise, reliable identification of GZL cases remains challenging. Here, we describe the histopathologic features of 139 GZL cases from a retrospective Lymphoma Study Association (LYSA) study with the goal to improve classification accuracy. Read More

View Article
December 2018
1 Read

Transoesophageal echocardiography current practice in France: A multicentre study.

Arch Cardiovasc Dis 2018 Dec 4;111(12):730-738. Epub 2018 Jul 4.

Department of cardiology, SOS Endocardites, Henri-Mondor Hospital, 94010 Creteil, France.

Background: Few data are available on the application of transoesophageal echocardiography (TOE) recommendations in daily practice.

Aims: To evaluate TOE practice based on echocardiography societies' guidelines, and to determine complication rates and factors associated with patient feelings.

Methods: Between April and June 2017, we prospectively included all consecutive patients referred to 14 French hospitals for a transoesophageal echocardiogram (TOE). Read More

View Article
December 2018

A new human pyridinium metabolite of furosemide, inhibitor of mitochondrial complex I, is a candidate inducer of neurodegeneration.

Biochem Pharmacol 2018 Dec 8;160:14-23. Epub 2018 Dec 8.

Université Paris-Est, Laboratoire CRRET ERL-CNRS 9215, UPEC, F-94010 Créteil, France. Electronic address:

Pharmaceuticals and their by-products are increasingly a matter of concern, because of their unknown impacts on human health and ecosystems. The lack of information on these transformation products, which toxicity may exceed that of their parent molecules, makes their detection and toxicological evaluation impossible. Recently we characterized the Pyridinium of furosemide (PoF), a new transformation product of furosemide, the most widely used diuretic and an emerging pollutant. Read More

View Article
December 2018

Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress.

Nat Commun 2018 12 7;9(1):5235. Epub 2018 Dec 7.

INSERM, UMR-1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Institut Universitaire d'Hématologie, Paris, 75010, France.

Cyclins A2 and E1 regulate the cell cycle by promoting S phase entry and progression. Here, we identify a hepatocellular carcinoma (HCC) subgroup exhibiting cyclin activation through various mechanisms including hepatitis B virus (HBV) and adeno-associated virus type 2 (AAV2) insertions, enhancer hijacking and recurrent CCNA2 fusions. Cyclin A2 or E1 alterations define a homogenous entity of aggressive HCC, mostly developed in non-cirrhotic patients, characterized by a transcriptional activation of E2F and ATR pathways and a high frequency of RB1 and PTEN inactivation. Read More

View Article
December 2018

Rare respiratory diseases in the ICU: when to suspect them and specific approaches.

Curr Opin Crit Care 2018 Dec 5. Epub 2018 Dec 5.

Université Paris Est Créteil, Faculté de Médecine de Créteil, Groupe de Recherche Clinique CARMAS, Créteil.

Purpose Of Review: A prompt identification of the cause of acute respiratory failure (ARF)/acute respiratory distress syndrome (ARDS) is required in order to initiate a targeted treatment. Yet, almost 10% of ARDS patients have no identified ARDS risk factor at ARDS diagnosis. Numerous rare causes of ARF have been reported in this setting. Read More

View Article
December 2018
1 Read

Breast cancer risk in neurofibromatosis type 1 is a function of the type of gene mutation: a new genotype-phenotype correlation.

J Med Genet 2018 Dec 10. Epub 2018 Dec 10.

Inherited Tumour Syndromes Research Group, Institute of Cancer & Genetics, Cardiff University, Cardiff, UK.

Background: Neurofibromatosis type 1 (NF1) predisposes to breast cancer (BC), but no genotype-phenotype correlations have been described.

Methods: Constitutional mutations in 78 patients with NF1 with BC (NF1-BC) were compared with the Leiden Open Variation Database (n=3432).

Results: No cases were observed with whole or partial gene deletions (HR 0. Read More

View Article
December 2018
6.335 Impact Factor

Oxaliplatin, 5-Fluorouracil and Nab-paclitaxel as perioperative regimen in patients with resectable gastric adenocarcinoma: A GERCOR phase II study (FOXAGAST).

Eur J Cancer 2018 Dec 7;107:46-52. Epub 2018 Dec 7.

Medical Oncology Department, Institut Mutualiste Montsouris, Paris, France. Electronic address:

Background: 5-Fluorouracil (5-FU) and platinum-based perioperative chemotherapy is standard of care for resectable gastric adenocarcinoma (RGA). Nanoparticle albumin-bound (Nab-) paclitaxel is active in advanced disease but has never been evaluated in the perioperative setting. The objective was to evaluate the efficacy of Nab-paclitaxel in combination with FOLFOX for RGA patients. Read More

View Article
December 2018
1 Read

Fast and inexpensive production of "homemade" PRP: A simple method.

J Plast Reconstr Aesthet Surg 2018 Nov 13. Epub 2018 Nov 13.

Department of Plastic & Reconstructive Surgery and Maxillo-Facial Surgery, Henri Mondor Hospital 51 avenue du Maréchal de Lattre de Tassigny, Créteil 94010, France.

View Article
November 2018

Haematological immune-related adverse events induced by anti-PD-1 or anti-PD-L1 immunotherapy: a descriptive observational study.

Lancet Haematol 2018 Dec 4. Epub 2018 Dec 4.

Service de Médecine Interne and Immunologie Clinique, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, France; Université Paris Sud, Centre de Recherche en Immunologie des Infections Virales et des Maladies Auto-Immunes, INSERM, Le Kremlin-Bicêtre, France; Division d'Immunovirologie, Commissariat à l'Energie Atomique et aux Energies Alternatives, Fontenay-aux-Roses, France.

Background: Anti-programmed cell death 1 (PD-1) and anti-programmed cell death ligand 1 (PD-L1) antibodies are novel immunotherapies for cancer that can induce immune-related adverse events (irAEs). These adverse events can involve all organs, including the haemopoietic system. Thus far, haematological irAEs (haem-irAEs) have not been extensively characterised. Read More

View Article
December 2018

Evaluation of septal insertion of atrioventricular valves in fetuses by postmortem 4.7 Tesla cardiac MRI: A feasibility study.

Diagn Interv Imaging 2018 Dec 7. Epub 2018 Dec 7.

Congenital and Pediatric Cardiology Unit, Centre de Référence Maladies Cardiaques Congénitales Complexes-M3C, hôpital Necker-Enfants Malades, AP-HP, 75006 Paris, France; Université Paris-Descartes, Sorbonne Paris Cité, 75005 Paris, France.

Purpose: The purpose of this study was to compare non-invasive high-spatial-resolution postmortem cardiac magnetic resonance imaging (MRI) and autopsy findings for evaluating the septal insertion of atrioventricular valves in fetuses.

Materials And Methods: Five fetal heart specimens including two normal hearts, one heart with complete atrioventricular septal defect (AVSD) and two hearts with linear insertion of atrioventricular valves (LIAVV; gestational age 17 to 34 weeks) were studied with cardiac MRI using a 4.7 T MRI scanner without sample preparation. Read More

View Article
December 2018

Severe Hypoglycemia Due to Cryptic Insulin Use in a Bodybuilder.

J Emerg Med 2018 Dec 6. Epub 2018 Dec 6.

Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Henri Mondor, Service d'Accueil des Urgences, Créteil, France; Université Paris-Est Créteil, Institut National de la Santé et de la Recherche Médicale U955, Créteil, France.

Background: Bodybuilding is a demanding sport, which requires high-volume, high-resistance weight training and augmented nutritional intake, toward an increase of overall body muscle mass accompanied by an overall decrease of body fat percentage and mass. Among bodybuilders, the use of various legal and illegal supplements is common. These supplements may be naturally occurring or man-made. Read More

View Article
December 2018

Body composition and sarcopenia: the next-generation of personalized oncology and pharmacology?

Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical Oncology, CAncer Research for PErsonalized Medicine (CARPEM), Paris Centre Teaching Hospitals, Paris Descartes University, USPC, Paris, France.

Body composition has gained increasing attention in oncology in recent years due to fact that sarcopenia has been revealed to be a strong prognostic indicator for survival across multiple stages and cancer types and a predictive factor for toxicity and surgery complications. Accumulating evidence over the last decade has unraveled the "pharmacology" of sarcopenia. Lean body mass may be more relevant to define drug dosing than the "classical" body surface area or flat-fixed dosing in patients with cancer. Read More

View Article
December 2018
4 Reads

The Interleukin-17 Family of Cytokines in Breast Cancer.

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

Institut Jean Godinot, Unicancer, F-51726 Reims, France.

Breast cancer (BC) is the most common cancer in women worldwide and remains a major cause of mortality with an expected 137,000 death this year in Europe. Standard management of metastatic BC comprises hormonotherapy, chemotherapy, and targeted therapies. Cyclin dependent kinase (CDK) and mammalian target of rapamycin (mTOR) inhibitors have recently proved their efficiency in hormonal receptor expressing BC. Read More

View Article
December 2018
1 Read

Dose de-escalation to adalimumab 40 mg every three weeks in patients with inflammatory bowel disease-A multicenter, retrospective, observational study.

Dig Liver Dis 2018 Nov 8. Epub 2018 Nov 8.

INSERM U954 and Department of Hepato-Gastroenterology, University Hospital of Nancy, Lorraine University, Vandoeuvre-lès-Nancy, France. Electronic address:

Background: Data about the outcomes after adalimumab dose de-escalation in inflammatory bowel disease (IBD) are scarce.

Objectives: To assess the outcomes after adalimumab dose de-escalation, and to identify potential factors associated with failure.

Methods: Retrospective, observational study including all IBD patients who had undergone adalimumab dose de-escalation to 40 mg every three weeks across seven GETAID centers, between June 2011 and September 2017. Read More

View Article
November 2018
1 Read

Resection of small bowel adenocarcinoma metastases: Results of the ARCAD-NADEGE cohort study.

Eur J Surg Oncol 2018 Nov 22. Epub 2018 Nov 22.

Department of Gastroenterology and Digestive Oncology, CHU Saint Louis, APHP, Denis Diderot University, Sorbonne Paris Cité, Paris, France. Electronic address:

Introduction: Data are lacking with regard to curative resection of metastasis from small bowel adenocarcinoma (SBA). This study evaluated outcomes and prognostic factors in patients with curatively resected metastatic SBA.

Methods: A series of 34 patients undergoing resection of metastatic SBA from January 2009 to November 2014 at French centers were included into this cohort study. Read More

View Article
November 2018

Assessing cross-national invariance of the Community Assessment of Psychic Experiences (CAPE).

Psychol Med 2018 Dec 5:1-8. Epub 2018 Dec 5.

AP-HP, DHU PePSY, Hôpitaux universitaires Henri-Mondor, Pôle de Psychiatrie,Créteil, 94000,France.

Background: The Community Assessment of Psychic Experiences (CAPE) is a 42-item self-report questionnaire that has been developed and validated to measure the dimensions of psychosis in the general population. The CAPE has a three-factor structure with dimensions of positive, negative and depression. Assessing the cross-national equivalence of a questionnaire is an essential prerequisite before pooling data from different countries. Read More

View Article
December 2018
9 Reads

Evolution of ST-Elevation Acute Myocardial Infarction Prevalence by Gender Assessed Age Pyramid Analysis-The Piramyd Study.

J Clin Med 2018 Dec 3;7(12). Epub 2018 Dec 3.

SAMU 93, UF Recherche-Enseignement-Qualité Avicenne Hospital-APHP, 93000 Bobigny, France.

Introduction: Recent studies reported a decrease in the incidence of acute myocardial infarction. This favorable evolution does not extend to young women. The interaction between gender, risk factors and myocardial infarction incidence remains controversial. Read More

View Article
December 2018

Drug-induced linear IgA bullous dermatosis: a French retrospective pharmacovigilance study of 69 cases.

Br J Clin Pharmacol 2018 Dec 4. Epub 2018 Dec 4.

EA 7379 EpiDermE, Université Paris Est Créteil Val de Marne UPEC, Créteil, France.

Aims: Linear immunoglobin A (IgA) bullous dermatosis (LABD) is a rare autoimmune dermatosis considered spontaneous or drug-induced (DILAD). We assessed all DILAD cases, determined the imputability score of drugs, highlighted suspected drugs.

Methods: Data for patients with DILAD were collected retrospectively from the French Pharmacovigilance network (from 1985 to 2017) and from physicians involved in the Bullous Diseases French Study Group and the French Investigators for Skin Adverse Reactions to Drugs. Read More

View Article
December 2018
2 Reads

Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism.

J Autism Dev Disord 2018 Dec 3. Epub 2018 Dec 3.

Institut National de la Santé et de la Recherche Médicale (INSERM), U955, Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle (Créteil, France), 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.

Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. Read More

View Article
December 2018
3 Reads

Acute haemolysis after transcatheter mitral valve implantation.

Eur Heart J 2018 Nov 29. Epub 2018 Nov 29.

Cardiology Department, Expert Valve Center, Henri Mondor Hospital, 51 Avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France.

View Article
November 2018

HIV-1 T cell epitopes targeted to Rhesus macaque CD40 and DCIR: A comparative study of prototype dendritic cell targeting therapeutic vaccine candidates.

PLoS One 2018 30;13(11):e0207794. Epub 2018 Nov 30.

Vaccine Research Institute, Université Paris-Est, Faculté de Médecine, INSERM U955, Créteil, France.

HIV-1 infection can be controlled by anti-retroviral drug therapy, but this is a lifetime treatment and the virus remains latent and rapidly rebounds if therapy is stopped. HIV-1-infected individuals under this drug regimen have increased rates of cancers, cardiovascular diseases, and autoimmunity due to compromised immunity. A therapeutic vaccine boosting cellular immunity against HIV-1 is therefore desirable and, possibly combined with other immune modulating agents, could obviate the need for long-term drug therapies. Read More

View Article
November 2018
2 Reads

The neurophysiology of deforming spastic paresis: A revised taxonomy.

Ann Phys Rehabil Med 2018 Nov 28. Epub 2018 Nov 28.

Service de rééducation neurolocomotrice, EA 7377 BIOTN, laboratoire analyse et restauration du mouvement, université Paris-Est Créteil, hôpitaux universitaires Henri-Mondor, Assistance publique-Hôpitaux de Paris, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.

This paper revisits the taxonomy of the neurophysiological consequences of a persistent impairment of motor command execution in the classic environment of sensorimotor restriction and muscle hypo-mobilization in short position. Around each joint, the syndrome involves 2 disorders, muscular and neurologic. The muscular disorder is promoted by muscle hypo-mobilization in short position in the context of paresis, in the hours and days after paresis onset: this genetically mediated, evolving myopathy, is called spastic myopathy. Read More

View Article
November 2018
1 Read

Sex- and age-adjusted prevalence estimates of skin types and unpleasant skin sensations and their consequences on the quality of life: Results from a study of a large representative sample of the French population.

Br J Dermatol 2018 Nov 30. Epub 2018 Nov 30.

Société Française de Dermatologie (SFD), Paris, France.

In France, the consumption of cosmetics was recently evaluated: the mean number of cosmetic products used daily by French consumers is 16 for women (18 if they are pregnant), 8 for men, 7 for girls (4-14 years old), 5 for boys (4-14 years old) and 6 for babies (0-3 years old, both sexes) , especially facial moisturizers, with a higher product exposure amounts than expected. Nonetheless, little is known about the prevalence of cosmetic disorders in the general population. This article is protected by copyright. Read More

View Article
November 2018

Sutureless versus Stented Bioprostheses for Aortic Valve Replacement: The Randomized PERSIST-AVR Study Design.

Thorac Cardiovasc Surg 2018 Nov 29. Epub 2018 Nov 29.

Department of Cardiac Surgery, Klinikum Nürnberg, Paracelsus Medical University, Nuremberg, Germany.

Introduction:  Sutureless biological valves for surgical aortic valve replacement (SAVR), characterized by the absence of anchoring sutures at the aortic annulus, are gaining popularity because of ease and reproducibility of implant, shorter operating times, and enhancement of minimally invasive approaches. The stentless configuration of the sutureless valve was designed to achieve optimal hemodynamic performance.

Materials And Methods:  PERSIST-AVR (PERceval Sutureless Implant versus STandard Aortic Valve Replacement) is a prospective, randomized, adaptive, open-label, international, postmarket trial (NCT02673697). Read More

View Article
November 2018

Chronic hepatitis B virus infection.

Lancet 2018 Nov;392(10161):2313-2324

Department of Medicine, The University of Hong Kong Queen Mary Hospital, Hong Kong Special Administrative Region, China; Department of Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address:

Chronic hepatitis B virus infection is a global public health threat that causes considerable liver-related morbidity and mortality. It is acquired at birth or later via person-to-person transmission. Vaccination effectively prevents infection and chronic hepatitis B virus carriage. Read More

View Article
November 2018
1 Read

An indirect treatment comparison of the efficacy of patisiran and tafamidis for the treatment of hereditary transthyretin-mediated amyloidosis with polyneuropathy.

Expert Opin Pharmacother 2018 Nov 29. Epub 2018 Nov 29.

e Johns Hopkins University , Baltimore , MD , USA.

Background: Hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis) is a progressive, life-threatening disease. Until recently, tafamidis was the only approved pharmacotherapy. Patisiran significantly improved polyneuropathy and Quality of life (QoL) in the phase III APOLLO study. Read More

View Article
November 2018
2 Reads

Critical steps for initiating an animal uterine transplantation model in sheep: Experience from a case series.

Int J Surg 2018 Nov 24;60:245-251. Epub 2018 Nov 24.

Department of Gynaecology and Obstetrics, Foch Hospital, Suresnes, France; EA-7404 GIG, UFR des Sciences de la Santé Simone Veil, 78180, Montigny le Bretonneux, France.

Background: Recent reports have demonstrated uterus transplantation as a relevant solution to treat absolute uterine infertility. Training on animal models is a prerequisite to set up a uterine transplantation program in humans. Sheep have been used as an optimal model for training and research as they display similar vessels size to human. Read More

View Article
November 2018

Clinical benefit of using a multifractional Er:YAG laser combined with a spatially modulated ablative (SMA) module for the treatment of striae distensae: A prospective pilot study in 20 patients.

Lasers Surg Med 2018 Nov 27. Epub 2018 Nov 27.

Department of Plastic, Reconstructive and Maxillo facial Surgery, Hopital Henri Mondor, Creteil, 94010, France.

Background And Objective: Striae distensae (SD) are cutaneous lesions that often occur on the breasts, abdomen, hips, and thighs. The aim of this study is to evaluate the effectiveness of a new technique using a non-invasive Er:YAG laser combined with Spatially Modulated Ablation (SMA) module for the treatment of SD.

Study Design/materials And Methods: This prospective pilot clinical study included 20 patients with skin phototypes I to IV who are affected by SD. Read More

View Article
November 2018
4 Reads

Imatinib: Major photocatalytic degradation pathways in aqueous media and the relative toxicity of its transformation products.

Sci Total Environ 2018 Nov 19;655:547-556. Epub 2018 Nov 19.

University of Paris-Sud, Department of Pharmacy, Laboratory "Matériaux et Santé" EA 401, 5 rue Jean Baptiste Clément, 92296 Châtenay-Malabry, France; Assistance Publique-Hôpitaux de Paris, Groupe hospitalier Henri Mondor, Department of Pharmacy, 51 Avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France.

Imatinib (IMA) is a highly potent tyrosine kinase inhibitor used as first-line anti-cancer drug in the treatment of chronic myeloid leukemia. Due to its universal mechanism of action, IMA also has endocrine and mutagenic disrupting effects in vivo and in vitro, which raises the question of its environmental impact. However, to date, very little information is available on its environmental fate and the potential role of its transformation products (TPs) on aquatic organisms. Read More

View Article
November 2018
2 Reads

Reply.

Gastroenterology 2018 Nov 23. Epub 2018 Nov 23.

Service d'Hépatologie, AP-HP, Hôpital Jean Verdier, Bondy, France and Inserm UMR-1162, "Functional Genomics of Solid Tumors", Université Paris Descartes, Université Paris Diderot, Labex Oncoimmunology, Equipe labellisée Ligue contre le Cancer, Paris, France.

View Article
November 2018

Targeted panel sequencing in adult patients with left ventricular non-compaction reveals a large genetic heterogeneity.

Clin Genet 2018 Nov 24. Epub 2018 Nov 24.

Sorbonne Universités, UPMC Univ. Paris 06, INSERM, UMR_S 1166 and ICAN Institute for Cardiometabolism and Nutrition, Paris.

Left ventricular non-compaction (LVNC) is a cardiomyopathy that may be of genetic origin, however few data are available about the yield of mutation, the spectrum of genes and allelic variations. The aim of this study was to better characterize the genetic spectrum of isolated LVNC in a prospective cohort of 95 unrelated adult patients through the molecular investigation of 107 genes involved in cardiomyopathies and arrhythmias. Fifty-two pathogenic or probably pathogenic variants were identified in 40 patients (42%) including 31 patients (32. Read More

View Article
November 2018
1 Read

Preoperative planning of tibial tubercle medialisation according to the trochlear groove angle.

Orthop Traumatol Surg Res 2018 Nov 20. Epub 2018 Nov 20.

Service de chirurgie orthopédique et traumatologique, hôpital Henri-Mondor, 40, avenue de Mal-de-Lattre-de-Tassigny, 94000 Créteil, France.

The tibial tubercle-trochlear groove distance (TT-TG) was first described four decades ago. Since then, a considerable body of research has become available on the pathophysiology of chronic patellar instability, whose diagnosis and treatment remain challenging. Tibial tubercle medialisation can correct an abnormal TT-TG. Read More

View Article
November 2018
5 Reads

Crazy'App: A web survey on representations and attitudes toward mental disorders using video testimonies.

Encephale 2018 Nov 20. Epub 2018 Nov 20.

Cermes3 - Centre de recherche médecine, sciences, santé, santé mentale et société, université Paris Descartes, 7, rue Guy-Môquet, BP 8, 94801 Villejuif cedex, France.

In the international context of efforts to combat the stigmatization of people with mental health problems, representations and attitudes about these illnesses have not to date been widely investigated in France. However, new technologies offer an unprecedented opportunity to collect such information on a large scale and to deploy more efficient action against stigma.

Objectives: The Crazy'App survey was designed as an instrument for studying potentially stigmatizing representations and attitudes towards mental disorders. Read More

View Article
November 2018
1 Read

Single-Procedure Outcomes and Quality-of-Life Improvement 12 Months Post-Cryoballoon Ablation in Persistent Atrial Fibrillation: Results From the Multicenter CRYO4PERSISTENT AF Trial.

JACC Clin Electrophysiol 2018 Nov 25;4(11):1440-1447. Epub 2018 Aug 25.

Centre Hospitalier Universitaire de Grenoble-Alpes, Grenoble, France.

Objectives: The CRYO4PERSISTENT AF (Cryoballoon Ablation for Early Persistent Atrial Fibrillation) trial aims to report long-term outcomes after a single pulmonary vein isolation (PVI)-only ablation procedure using the second-generation cryoballoon in persistent atrial fibrillation (PerAF) patients.

Background: Pulmonary vein isolation is recognized as the cornerstone of atrial fibrillation (AF) ablation, including ablation of PerAF.

Methods: The CRYO4PERSISTENT AF trial (NCT02213731) is a prospective, multicenter, single-arm trial designed to assess single-procedure outcomes of PVI using the cryoballoon. Read More

View Article
November 2018
1 Read

Continued vs. interrupted direct oral anticoagulants at the time of device surgery, in patients with moderate to high risk of arterial thrombo-embolic events (BRUISE CONTROL-2).

Eur Heart J 2018 Nov;39(44):3973-3979

Hôpital du Sacré-Coeur de Montréal, 5400 boul Gouin Ouest, Montreal, QC, Canada.

Aims: Guidelines recommend warfarin continuation rather than heparin bridging for pacemaker and defibrillator surgery, after the BRUISE CONTROL trial demonstrated an 80% reduction in device pocket haematoma with this approach. However, direct oral anticoagulants (DOACs) are now used to treat the majority of patients with atrial fibrillation. We sought to understand the best strategy to manage the DOACs at the time of device surgery and specifically hypothesized that performing device surgery without DOAC interruption would result in a reduced haematoma rate. Read More

View Article
November 2018
4 Reads

Prevalence and Description of Hidradenitis Suppurativa in Down Syndrome: A Cross-sectional Study of 783 Subjects.

Acta Derm Venereol 2018 Nov 21. Epub 2018 Nov 21.

Department of Dermatology, hôpital Henri Mondor, Assistance Publique Hôpitaux de Paris, 51 avenue du Maréchal de Lattre de Tassigny, FR-94000 Créteil, France.

View Article
November 2018
1 Read

Effects of patient positioning on respiratory mechanics in mechanically ventilated ICU patients.

Ann Transl Med 2018 Oct;6(19):384

Service de réanimation médicale, Hôpital de la Croix Rousse, Hospices civils de Lyon, Lyon, France.

Changes in the body position of patients receiving mechanical ventilation in intensive care unit are frequent. Contrary to healthy humans, little data has explored the physiological impact of position on respiratory mechanics. The objective of present paper is to review the available data on the effect of changing body position on respiratory mechanics in ICU patients receiving mechanical ventilation. Read More

View Article
October 2018
3 Reads

Adverse Event with the Use of Carmustine Wafers and Postoperative Radiochemotherapy for the Treatment of High-grade Glioma.

Asian J Neurosurg 2018 Oct-Dec;13(4):1171-1174

Department of Neurosurgery, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Henri-Mondor Albert-Chenevier, PePsy Department, F-94010 Créteil, France.

Randomized, controlled trials have shown significant improvement of survival after implantation of 1,3-bis(2-Chloroethyl)-1-nitrosourea (BCNU) wafers for patients suffering from high-grade glioma. A combination of local chemotherapy with BCNU and concomitant radiochemotherapy with temozolomide (TMZ) appears to be attractive to enhance the overall survival, even though these treatments may potentially cumulate their toxicity. We report a clinical case of a patient submitted to this combined treatment protocol. Read More

View Article
November 2018

Minimal change nephrotic syndrome in patients infected with human immunodeficiency virus: a retrospective study of 8 cases.

BMC Nephrol 2018 Nov 20;19(1):331. Epub 2018 Nov 20.

AP-HP (Assistance Publique-Hôpitaux de Paris), Service de Néphrologie et de Transplantation, Centre de Référence Maladie Rare Syndrome Néphrotique Idiopathique, Hôpital Henri-Mondor/Albert-Chenevier, F-94000, Créteil, France.

Background: Human immunodeficiency virus (HIV) is associated with diverse glomerular diseases. Characteristics of minimal change nephrotic syndrome (MCNS) in this setting have been little studied, and the specific features of this uncommon association remain to be determined.

Methods: We conduct a retrospective study. Read More

View Article
November 2018
6 Reads

Oral Cavity Cancer.

Oral Maxillofac Surg Clin North Am 2019 Feb 25;31(1):13-29. Epub 2018 Oct 25.

Division of Head and Neck Surgery, Head and Neck Oncologic Surgery and Microvascular Reconstruction Fellowship, Department of Oral and Maxillofacial Surgery, University of Florida College of Medicine - Jacksonville, University of Florida - Jacksonville, 653-1 West 8th Street 2nd FL/LRC, Jacksonville, FL 32209, USA. Electronic address:

Management of oral cavity squamous cell carcinoma has become increasingly driven by emerging evidence as a result of the improved quality of clinical research associating clinicopathologic risk factors with oncologic and survival outcomes. Multiple significant recent changes to treatment guidelines and staging algorithms for oral cavity squamous cell carcinoma reflect evolving understanding of tumor biology and the need for adequately extensive treatment of aggressive disease. This article provides clinicians with a synopsis of the most contemporary management strategies for oral cavity squamous cell carcinoma, framed within the context of historical treatment philosophies. Read More

View Article
February 2019
4 Reads