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    Self-reported history of stroke and long-term living conditions near air pollution sources: results of a national epidemiological study in Lebanon.
    Environ Monit Assess 2018 Feb 20;190(3):153. Epub 2018 Feb 20.
    Department of Neurology, Henri Mondor Hospital AP-HP, Creteil, France.
    Stroke is a disease related to high mortality and morbidity, particularly in developing countries. Some studies have linked self-reported indoor and outdoor pollution to stroke and mini-stroke, while some others showed no association. Our objective was to assess this association in Lebanon, a Middle Eastern developing country. Read More

    Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers.
    Alzheimers Dement 2018 Feb 16. Epub 2018 Feb 16.
    Memory Resource and Research Centre of Montpellier, Department of Neurology, CHU Gui de Chauliac, Université de Montpellier, Montpellier, France.
    Backgrounds: Diagnostic relevance of plasma amyloid β (Aβ) for Alzheimer's disease (AD) process yields conflicting results.

    Objectives: To assess plasma levels of Aβand Aβin amnestic mild cognitive impairment (MCI), nonamnestic MCI, and AD patients and to investigate relationships between peripheral and central biomarkers.

    Methods: One thousand forty participants (417 amnestic MCI, 122 nonamnestic MCI, and 501 AD) from the Biomarker of AmyLoïd pepTide and AlZheimer's diseAse Risk multicenter prospective study with cognition, plasma, cerebrospinal fluid (CSF), and magnetic resonance imaging assessments were included. Read More

    Hypertension prevalence and living conditions related to air pollution: results of a national epidemiological study in Lebanon.
    Environ Sci Pollut Res Int 2018 Feb 13. Epub 2018 Feb 13.
    Department of Neurology, Henri Mondor Hospital AP-HP, Creteil, France.
    Hypertension is a risk factor of several diseases, linked to high mortality and morbidity, particularly in developing countries. Some studies have linked indoor and outdoor pollution exposure items to hypertension, but results were inconsistent. Our objective was to assess the association of living conditions related to air pollution to hypertension in Lebanon, a Middle Eastern country. Read More

    New NO Donor NCX 1443: Therapeutic Effects on Pulmonary Hypertension in the SAD Mouse Model of Sickle Cell Disease.
    J Cardiovasc Pharmacol 2018 Feb 8. Epub 2018 Feb 8.
    Nicox Research Institute Via Ariosto, Milan, Italy.
    Nitric oxide (NO) donors may be useful for treating pulmonary hypertension (PH) complicating sickle cell disease (SCD), as endogenous NO is inactivated by hemoglobin released by intravascular hemolysis. Here, we investigated the effects of the new NO donor NCX1443 on PH in transgenic SAD mice, which exhibit mild SCD without severe hemolytic anemia. In SAD and wild-type (WT) mice, the pulmonary pressure response to acute hypoxia was similar and was abolished by 100 mg/kg NCX1443. Read More

    [Epidemiology of atopic dermatitis].
    Ann Dermatol Venereol 2017 Dec;144 Suppl 5:VS4-VS7
    Department of Dermatology, Henri-Mondor Hospital ; Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
    Atopic dermatitis (AD) is a chronic pruriginous skin disease which usually begins during early life (before the age of 2 years). Recently, the persistence of the disease in adulthood has been clearly established at least in a subset of patients, with frequent moderate to severe forms. The exact prevalence of the disease varies according to the study design and its estimate remains difficult mainly because of the lack of consensual diagnostic tools easily usable in population studies. Read More

    Patterns of Clinical Response to Eculizumab in Patients With C3 Glomerulopathy.
    Am J Kidney Dis 2018 Feb 8. Epub 2018 Feb 8.
    Department of Nephrology and Immunology, Centre Hospitalier Universitaire de Nantes, Nantes, France. Electronic address:
    Background: Cases reports and small series of patients with C3 glomerulopathy have reported variable efficacy of eculizumab.

    Study Design: Case series of C3 glomerulopathy.

    Setting & Participants: Pediatric and adult patients with C3 glomerulopathy treated with eculizumab between 2010 and 2016 were identified through the C3 glomerulopathy French registry database, and a questionnaire was sent to participating French pediatric and adult nephrology centers, as well as one pediatric referral center in Québec, Canada. Read More

    mTOR pathway activation drives lung cell senescence and emphysema.
    JCI Insight 2018 Feb 8;3(3). Epub 2018 Feb 8.
    INSERM U955, Département de Physiologie-Explorations Fonctionnelles, and DHU A-TVB Hôpital Henri Mondor, AP-HP, Créteil, France.
    Chronic obstructive pulmonary disease (COPD) is a highly prevalent and devastating condition for which no curative treatment is available. Exaggerated lung cell senescence may be a major pathogenic factor. Here, we investigated the potential role for mTOR signaling in lung cell senescence and alterations in COPD using lung tissue and derived cultured cells from patients with COPD and from age- and sex-matched control smokers. Read More

    Reply to "Comparison of antipseudomonal betalactams for febrile neutropenia empiric therapy: systematic review and network meta-analysis" by Horita et al.
    Clin Microbiol Infect 2018 Feb 2. Epub 2018 Feb 2.
    Assistance Publique-Hôpitaux de Paris (APHP) - Henri Mondor, Haematology Department and University Paris-Est Créteil, F-94010, Créteil, France.

    2017 Update of French Society for Rheumatology (SFR) Recommendations about the Everyday Management of Patients with Spondyloarthritis.
    Joint Bone Spine 2018 Jan 30. Epub 2018 Jan 30.
    Paris Descartes University, Department of Rheumatology, Hôpital Cochin, AP-HP, EULAR center of excellence, Paris, France; INSERM (UU1153), Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité, Paris 14, France.
    Objective: To update French Society for Rheumatology recommendations about the management in clinical practice of patients with spondyloarthritis (SpA). SpA is considered across the range of clinical phenotypes (axial, peripheral, and entheseal) and concomitant manifestations. Psoriatic arthritis is included among the SpA phenotypes. Read More

    The optimal timing of Hepatitis C therapy in liver transplant eligible patients: cost-effectiveness analysis of new opportunities.
    J Viral Hepat 2018 Feb 6. Epub 2018 Feb 6.
    International Center for Disease Health (ICDH), University of Milan-Bicocca, Monza, Italy.
    Different strategies of DAAs treatment are currently possible both pre and post liver-transplantation (LT). Clinical and economic consequences of these strategies still need to be adequately investigated; this study aims at assessing their cost-effectiveness. A decision-analytical model was created to simulate the progression of HCV-infected patients listed for decompensated cirrhosis (DCC) or for Hepatocellular carcinoma (HCC). Read More

    Simple, Reproducible, and Efficient Clinical Grading System for Murine Models of Acute Graft-versus-Host Disease.
    Front Immunol 2018 22;9:10. Epub 2018 Jan 22.
    Université Paris-Est, UMR_S955, Université Paris-Est Créteil Val de Marne, Créteil, France.
    Acute graft-versus-host disease (aGVHD) represents a challenging complication after allogeneic hematopoietic stem cell transplantation. Despite the intensive preclinical research in the field of prevention and treatment of aGVHD, and the presence of a well-established clinical grading system to evaluate human aGVHD, such a valid tool is still lacking for the evaluation of murine aGVHD. Indeed, several scoring systems have been reported, but none of them has been properly evaluated and they all share some limitations: they incompletely reflect the disease, rely on severity stages that are distinguished by subjective assessment of clinical criteria and are not easy to discriminate, which could render evaluation more time consuming, and their reproducibility among different experimenters is uncertain. Read More

    Refractory relapsing polychondritis: challenges and solutions.
    Open Access Rheumatol 2018 9;10:1-11. Epub 2018 Jan 9.
    Department of Rheumatology, Henri Mondor Hospital, University Paris 12, Créteil, France.
    Relapsing polychondritis is a severe systemic immune-mediated disease characterized by an episodic and progressive inflammatory condition with progressive destruction of cartilaginous structures. This disease has for nearly a century kept secrets not yet explained. The real incidence and prevalence of this rare disease are unknown. Read More

    Adolescence/adult onset MTHFR deficiency may manifest as isolated and treatable distinct neuro-psychiatric syndromes.
    Orphanet J Rare Dis 2018 Feb 1;13(1):29. Epub 2018 Feb 1.
    Neurology Department, Reference Center for Lysosomal Diseases, Neurogenetics and Metabolism Unit, AP-HP, GH Pitié-Salpêtrière-Charles Foix, Paris, France.
    5,10-Methylene-tetrahydrofolate reductase (MTHFR) deficiency is a genetic disorder that can occur at any age and can be easily detected by increased homocysteinemia. In adolescence/adult onset forms, the clinical picture is often complex with association of various neurological features and thrombosis.Here we report the cases of two adult siblings who experienced focal epilepsy at 18 years old as a first disease manifestation, without other symptom during several years. Read More

    Penile Mondor's disease in a patient treated with radical chemoradiation for anal cancer.
    Oxf Med Case Reports 2017 Aug 2;2017(8):omx036. Epub 2017 Aug 2.
    Department of Radiation Oncology, Bank of Cyprus Oncology Center 2006, Strovolos 2012, Nicosia, Cyprus.
    Penile Mondor's disease is a rare condition characterized by sclerosing thrombophlebitis of the superficial dorsal penile vein. Usually its causes are benign, but it is also evident in cancer patients. We report the case of a 62-year-old man with a cT4 anal cancer (infiltration of corpora spongiosa and penile bulb), associated with extensive loco-regional lymphadenopathy, who developed painful lumps in the midline of the anterior penile surface while receiving radical chemoradiotherapy. Read More

    Extranodal natural killer/T-cell lymphoma, nasal type, in Senegal.
    Int J Dermatol 2018 Jan 30. Epub 2018 Jan 30.
    Department of Dermatology, Aristide LeDantec University Hospital, Dakar, Senegal.
    Introduction: The distribution of extranodal NK/T-cell lymphoma (ENKTCL) is highly inhomogeneous throughout the world. In Sub-Saharan Africa, despite the precocity of Epstein-Barr virus (EBV) infection and its endemicity, ENKTCL remains exceptionally reported. The purpose of this study was to report the epidemiological, clinical, paraclinical, and evolutionary characteristics of ENKTCL at the Aristide LeDantec University Hospital in Dakar, Senegal. Read More

    Locoregional treatments before liver transplantation for hepatocellular carcinoma: a study from the European Liver Transplant Registry.
    Transpl Int 2018 Jan 30. Epub 2018 Jan 30.
    Department of Surgical Gastroenterology and Transplantation, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
    Locoregional treatment while on the waiting list for liver transplantation (Ltx) for hepatocellular carcinoma (HCC) has been shown to improve survival. However, the effect of treatment type has not been investigated. We investigate the effect of locoregional treatment type on survival after Ltx for HCC. Read More

    [Notions of epidemiology of value in dermatology].
    Ann Dermatol Venereol 2018 Jan 19. Epub 2018 Jan 19.
    Service de santé publique, Hôpital Henri-Mondor, AP-HP, EA 4393, Clinical Epidemiology and Ageing (CEpiA), Université Paris-Est (UPEC), 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France.
    Epidemiology, which was initially confined to the distribution of diseases in populations (descriptive epidemiology) and the factors responsible for such distribution (analytical epidemiology), also involves the evaluation of diagnostic and therapeutic strategies, as well as prognostic factors. Epidemiology provides elements that form the basis for medical and public health decisions. Information is collected from systematic records, which include large databases, or through specific surveys. Read More

    High predictive value of brain MRI imaging in primary mitochondrial respiratory chain deficiency.
    J Med Genet 2018 Jan 22. Epub 2018 Jan 22.
    Department of Pediatric Radiology, INSERM UMR 1163 and INSERM U1000, Paris Descartes University, Sorbonne Paris Cité, Hôpital Necker-Enfants Malades, Paris, France.
    Background: Because the mitochondrial respiratory chain (RC) is ubiquitous, its deficiency can theoretically give rise to any symptom in any organ or tissue at any age with any mode of inheritance, owing to the twofold genetic origin of respiratory enzyme machinery, that is, nuclear and mitochondrial. Not all respiratory enzyme deficiencies are primary and secondary or artefactual deficiency is frequently observed, leading to a number of misleading conclusions and inappropriate investigations in clinical practice. This study is aimed at investigating the potential role of brain MRI in distinguishing primary RC deficiency from phenocopies and other aetiologies. Read More

    T-cell papulosis associated with B-cell malignancy: a distinctive clinicopathologic entity.
    J Eur Acad Dermatol Venereol 2018 Jan 22. Epub 2018 Jan 22.
    Service de Dermatologie, Hôpital Robert Debré, Reims, France.
    Background: A distinctive eruption referred to as 'insect bite-like reaction' or 'eosinophilic dermatosis of haematological malignancy' has been described during the course of haematological B-cell malignancies (BCM). However, its clinical evolution, histopathological features and pathogenesis remain unclear.

    Objectives: To characterize this eruption and to investigate its pathogenesis and relationship with the underlying BCM. Read More

    Association between CRP genetic diversity and bipolar disorder comorbid complications.
    Int J Bipolar Disord 2018 Jan 20;6(1). Epub 2018 Jan 20.
    INSERM, U1160, Hôpital Saint Louis, 75010, Paris, France.
    Background: Chronic low-grade inflammation is believed to contribute, at least in a subset of patients, to the development of bipolar disorder (BD). In this context, the most investigated biological marker is the acute phase response molecule, C-reactive protein (CRP). While the genetic diversity of CRP was amply studied in various pathological settings, little is known in BD. Read More

    Phase II study of oral JAK1/JAK2 inhibitor ruxolitinib in advanced relapsed/refractory Hodgkin lymphoma.
    Haematologica 2018 Jan 19. Epub 2018 Jan 19.
    CHU Lille, Hematology Department, and Université de Lille, GRITA, Lille, France
    JAK2 constitutive activation/overexpression is common in classical Hodgkin lymphoma, and several cytokines stimulate Hodgkin lymphoma cells by recognizing JAK1-/JAK2-bound receptors. JAK blockade may thus be therapeutically beneficial in HL. This Phase II study assessed the safety and efficacy of ruxolitinib, an oral JAK1/2 inhibitor, in relapsed/refractory Hodgkin lymphoma patients. Read More

    Acceptability of HIV cure-related trials: the challenges for physicians and people living with HIV (ANRS-APSEC).
    AIDS Care 2018 Jan 18:1-7. Epub 2018 Jan 18.
    b Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale , Marseille , France.
    Essential HIV cure-related clinical trials (HCRCT) have a potentially high-risk profile in terms of participants' health, which could hinder enrollment by people living with HIV (PLWH) and healthcare professionals (HP). The ANRS-APSEC survey is part of the IAS "Towards an HIV cure" initiative, which promotes multidisciplinary research for a safe, affordable and scalable cure. The study objectives were to understand the psychosocial mechanisms underlying PLWH and HP viewpoints about future HCRCT. Read More

    High Neutrophil to Lymphocyte Ratio Is Associated With Symptomatic and Ruptured Thoracic Aortic Aneurysm.
    Angiology 2018 Jan 1:3319717751758. Epub 2018 Jan 1.
    1 Department of Vascular Surgery, Henri Mondor University Hospital, Créteil, Paris, France.
    The predictive value of the neutrophil to lymphocyte ratio (NLR) has been demonstrated in several cardiovascular diseases. The aim of our study was to investigate the association between the preoperative NLR and aneurysm characteristics as well as 30-day postoperative morbidity and mortality in patients with thoracic aortic aneurysm (TAA) undergoing aortic surgical repair. Consecutive patients (n = 75) with TAA were retrospectively included over a 10-year period. Read More

    Better outcome with haploidentical over HLA-matched related donors in patients with Hodgkin's lymphoma undergoing allogeneic haematopoietic cell transplantation-a study by the Francophone Society of Bone Marrow Transplantation and Cellular Therapy.
    Bone Marrow Transplant 2018 Jan 12. Epub 2018 Jan 12.
    CHRU Lille, Pôle Spécialités Médicales et Gérontologie (Medical Specialities and Gerontology), Service des Maladies du Sang (Department of Haematology), Secteur Allogreffe de Cellules Souches Hématopoïétiques (Allogeneic Stem Cell Transplantation Department), F59037, Lille, France.
    The question of the best donor type between haploidentical (HAPLO) and matched-related donors (MRD) for patients with advanced HL receiving an allogeneic hematopoietic cell transplantation (allo-HCT) is still debated. Given the lack of data comparing these two types of donor in the setting of non-myeloablative (NMA) or reduced-intensity (RIC) allo-HCT, we performed a multicentre retrospective study using graft-vs.-host disease-free relapse-free survival (GRFS) as our primary endpoint. Read More

    Systemic IL-2/anti-IL-2Ab complex combined with sublingual immunotherapy suppresses experimental food allergy in mice through induction of mucosal regulatory T cells.
    Allergy 2018 Jan 10. Epub 2018 Jan 10.
    Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP), CONICET y Universidad Nacional de La Plata, La Plata.
    Therapeutic tolerance restoration has been proven to modify food allergy in patients and animal models and although sublingual immunotherapy (SLIT) has showed promise, combined therapy may be necessary to achieve a strong and long-term tolerance. In this work, we combined SLIT with systemic administration of IL-2 associated with an anti-IL-2 monoclonal antibody (IL-2/anti-IL-2Ab complex or IL-2C) to reverse the IgE-mediated experimental allergy. Balb/c mice were sensitized with cholera toxin and milk proteins and orally challenged with allergen to elicit hypersensitivity reactions. Read More

    Stem cell therapy in early post-traumatic talus osteonecrosis.
    Int Orthop 2018 Jan 5. Epub 2018 Jan 5.
    Department of Orthopaedic Surgery, University Paris East (UPEC), Hôpital Henri Mondor, 94010, Creteil, France.
    Purpose: Avascular necrosis of the talus is one of the most notable complications associated with talar neck fractures with frequent evolution of the osteonecrosis into a difficult arthrodesis. We tested whether the injection of bone marrow mesenchymal stem cells (MSCs) could improve the repair process of the osteonecrosis.

    Material And Methods: Forty-five early (without collapse) post-traumatic talus osteonecroses (group 1; study group) were treated between 1995 and 2012 with percutaneous injection of progenitor cells (autologous bone marrow concentrate from the iliac crest). Read More

    Low fetal hemoglobin percentage is associated with silent brain lesions in adults with homozygous sickle cell disease.
    Blood Adv 2017 Dec 1;1(26):2503-2509. Epub 2017 Dec 1.
    Sickle Cell Referral Center, Service de Médecine Interne, Hôpital Henri-Mondor (Assistance Publique-Hôpitaux de Paris [APHP]), UPEC, INSERM U895, Team 2, Laboratoire d'Excellence GRex, Créteil, France.
    Silent white matter changes (WMCs) on brain imaging are common in individuals with sickle cell disease (SCD) and are associated with cognitive deficits in children. We investigated the factors predictive of WMCs in adults with homozygous SCD and no history of neurological conditions. Patients were recruited from a cohort of adults with homozygous SCD followed up at an adult sickle cell referral center for which steady-state measurements of biological parameters and magnetic resonance imaging scans of the brain were available. Read More

    TNFR2: The new Treg switch?
    Oncoimmunology 2017 21;7(1):e1373236. Epub 2017 Sep 21.
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
    Three recent publications identified the TNF/TNR2 pathway as a new target to reduce graft-versus-host-disease through regulatory T cells activation or to potentially switch on a strong anti-leukemic effect through regulatory T cells blockade in allogeneic hematopoietic stem cell transplantation. This identified the TNF/TNR2 pathway as a swith and as a new target for immune checkpoint therapy to modulate the immune regulation in this clinical setting. Read More

    Incidence and impact of implant subsidence after stand-alone lateral lumbar interbody fusion.
    Orthop Traumatol Surg Res 2017 Dec 30. Epub 2017 Dec 30.
    Institut Parisien-du-Dos, Clinique Geoffroy-Saint-Hilaire, Paris, France.
    Background: Few data are available on the occurrence after stand-alone lateral lumbar interbody fusion (LLIF) of implant subsidence, whose definition and incidence vary across studies. The primary objective of this work was to determine the incidence of subsidence 1 year postoperatively, using an original measurement method, whose validity was first assessed. The secondary objective was to assess the clinical impact of subsidence. Read More

    [Cell-mediated immunity: Lupus and connective tissue diseases].
    Ann Pathol 2018 Feb 28;38(1):43-54. Epub 2017 Dec 28.
    Département de pathologie, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address:
    Lupus can present itself in a multitude of clinical and histopathological manifestations. Cutaneous lesions can be very variable either from the clinical point of view or at the microscopic scale. Signs can be specific, concerning the dermo-epidermal stage, the dermal stage or the hypodermal stage. Read More

    Risk Factors for Mortality and Morbidity in Elderly Patients Presenting with Digestive Surgical Emergencies.
    World J Surg 2017 Dec 30. Epub 2017 Dec 30.
    Department of Digestive, Hepato-Bilio-Pancreatic Surgery Unit and Liver Transplantation, AP-HP Henri-Mondor Hospital, Université Paris, Est - UPEC, Est - 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Creteil, France.
    Background: Emergency digestive surgery is being increasingly performed in elderly patients. The aim of the present study was to identify the predictors of mortality and morbidity following emergency digestive surgery in patients aged 80 years and older.

    Methods: A single-center retrospective review was performed of consecutive patients aged ≥65 years operated for a digestive surgical emergency between January 2011 and December 2013. Read More

    [Humoral immune diseases: Cutaneous vasculitis and auto-immune bullous dermatoses].
    Ann Pathol 2018 Feb 27;38(1):31-42. Epub 2017 Dec 27.
    Département de pathologie, service d'anatomie et de cytologie pathologiques, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address:
    Humoral immunity is the cause of multiple diseases related to antibodies (IgA, IgG, IgM) produced by the patient. Two groups of diseases are identified. The first group is related to circulating antigen-antibody complexes. Read More

    Macrotrabecular-massive hepatocellular carcinoma: A distinctive histological subtype with clinical relevance.
    Hepatology 2017 Dec 27. Epub 2017 Dec 27.
    Inserm, U955, Team 18, Créteil, France; Université Paris-Est Créteil, Faculté de Médecine, Créteil, France.
    We recently identified a novel histological subtype of hepatocellular carcinoma, designated as "macrotrabecular-massive" (MTM-HCC) and associated with specific molecular features. In order to assess the clinical relevance of this novel variant, we aimed to investigate its prognostic value in two large series of patients with HCC treated either by surgical resection or radiofrequency ablation (RFA). We retrospectively included 237 HCC surgical samples and 284 HCC liver biopsies from patients treated by surgical resection and RFA, respectively. Read More

    Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models.
    Cell Rep 2017 Dec;21(13):3681-3690
    Duke Human Vaccine Institute, Duke School of Medicine, Durham, NC 27710, USA; Department of Medicine and Immunology, Duke School of Medicine, Durham, NC 27710, USA. Electronic address:
    The events required for the induction of broad neutralizing antibodies (bnAbs) following HIV-1 envelope (Env) vaccination are unknown, and their induction in animal models as proof of concept would be critical. Here, we describe the induction of plasma antibodies capable of neutralizing heterologous primary (tier 2) HIV-1 strains in one macaque and two rabbits. Env immunogens were designed to induce CD4 binding site (CD4bs) bnAbs, but surprisingly, the macaque developed V1V2-glycan bnAbs. Read More

    Hip osteonecrosis and pregnancy in healthy women.
    Int Orthop 2017 Dec 26. Epub 2017 Dec 26.
    Hôpital Henri Mondor, University Paris East (UPEC), 94010, Creteil, France.
    Purpose: Osteonecrosis has been reported to be associated with pregnancy in the absence of other known risk factors for the disease. Few population-based data exist to support an association since the association is rare. We investigated the association of the femoral head and pregnancy to define if pregnancy was a risk factor and to define the risk period. Read More

    Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma.
    Hepatology 2017 Dec 26. Epub 2017 Dec 26.
    Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.
    Intrahepatic cholangiocarcinoma (iCCA) remains a highly heterogeneous malignancy that has eluded effective patient stratification to date. The extent to which such heterogeneity can be influenced by individual driver mutations remains to be evaluated. Here, we analyzed genomic (whole-exome sequencing, targeted exome sequencing) and epigenomic data from 496 patients, and used the three most recurrently mutated genes to stratify patients (IDH, KRAS, TP53, 'undetermined'). Read More

    Rating scales for cognition in Huntington's disease: Critique and recommendations.
    Mov Disord 2018 Feb 26;33(2):187-195. Epub 2017 Dec 26.
    National Center of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain.
    Cognitive impairment is one of the main features of Huntington's disease and is present across the disease spectrum. As part of the International Parkinson's Disease and Movement Disorder Society-sponsored project to review all clinical rating scales used in Huntington's disease, a systematic review of the literature was performed to identify cognitive scales used in Huntington's disease and make recommendations for their use. A total of 17 cognitive scales were identified and evaluated. Read More

    Early Identification of Acute Respiratory Distress Disorder in the Absence of Positive Pressure Ventilation: Implications for Revision of the Berlin Criteria for Acute Respiratory Distress Syndrome.
    Crit Care Med 2017 Dec 21. Epub 2017 Dec 21.
    CHU de Poitiers, Service de Réanimation Médicale, Poitiers, France.
    Objectives: To assess whether patients breathing spontaneously under standard oxygen could be recognized early as acute respiratory distress syndrome patients according to the current Berlin definition.

    Design: A post hoc analysis from two prospective studies.

    Setting: Twenty-three French ICUs. Read More

    Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.
    Cochrane Database Syst Rev 2017 12 22;12:CD011535. Epub 2017 Dec 22.
    Department of Dermatology, Hôpital Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, Créteil, France, 94000.
    Background: Psoriasis is an immune-mediated disease for which some people have a genetic predisposition. The condition manifests in inflammatory effects on either the skin or joints, or both, and it has a major impact on quality of life. Although there is currently no cure for psoriasis, various treatment strategies allow sustained control of disease signs and symptoms. Read More

    Dramatic increase of amoxicillin induced crystal nephropathy: a cohort study from the French pharmacovigilance.
    Antimicrob Agents Chemother 2017 Dec 20. Epub 2017 Dec 20.
    Service d'Anesthésie et des Réanimations Chirurgicales - DHU A-TVB, Assistance Publique des Hôpitaux de Paris, Hôpitaux Universitaires Henri Mondor, Créteil, France.
    An increase in amoxicillin induced crystal nephropathy (AICN) incidence has been recently suggested. The aims of this study were to investigate the trend of AICN incidence through Paris' regional centers of pharmacovigilance (Paris-RCPVs) and better describe this rare adverse drug reaction. Forty-five AICN cases were identified between 1985 and 2016. Read More

    Trastuzumab beyond progression in patients with HER2-positive advanced gastric adenocarcinoma: a multicenter AGEO study.
    Oncotarget 2017 Nov 8;8(60):101383-101393. Epub 2017 Sep 8.
    Department of Gastroenterology and Digestive Oncology, European Georges Pompidou Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
    Introduction: Trastuzumab in combination with platinum-based chemotherapy is the standard first-line regimen in HER2-positive advanced gastric cancer. However, there are very few data concerning efficacy of continuing trastuzumab beyond first-line progression.

    Methods: This retrospective multicenter study included all consecutive patients with HER2-positive advanced gastric or gastro-esophageal junction (GEJ) adenocarcinoma who received a second-line of chemotherapy with or without trastuzumab after progression on platinum-based chemotherapy plus trastuzumab. Read More

    Role of up-front autologous stem cell transplantation in peripheral T-cell lymphoma for patients in response after induction: An analysis of patients from LYSA centers.
    Ann Oncol 2017 Dec 15. Epub 2017 Dec 15.
    Hematology Department, CHU Lyon Sud, Hospices Civils de Lyon, Pierre Benite, France.
    Background: Peripheral T-cell lymphoma (PTCL) remains a therapeutic challenge. Due to the rarity and the heterogeneity of PTCL, no consensus has been achieved regarding even the type of first-line treatment. The benefit of autologous stem cell transplant (ASCT) is, therefore, still intensely debated. Read More

    [What's new in internal medicine?]
    Ann Dermatol Venereol 2017 Dec;144 Suppl 4:IVS23-IVS28
    Service de dermatologie, hôpital Henri-Mondor, 94000 Créteil. Electronic address:
    As it is practiced in France, internal medicine meets the Anglo-Saxon definition of the specialty, ie doctors "equipped to handle the broad and comprehensive spectrum of illnesses that affect adults, and are recognized as experts in diagnosis, in treatment of chronic illness, and in health promotion and disease prevention - they are not limited to one type of medical problem or organ system". This 2017 "What's new in internal medicine" will consist of 2 parts, a first part on significant publications in the field of systemic and autoimmune diseases and a second part on more diverse publications (HIV, cancer, pregnancy, well-being.. Read More

    Transthyretin familial amyloid polyneuropathy: an update.
    J Neurol 2017 Dec 16. Epub 2017 Dec 16.
    Department of Neurology and Amyloid Network, University Hospital Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, 94000, Créteil, France.
    Transthyretin familial amyloid polyneuropathy (TTR-FAP) is a progressive, fatal, inherited disorder first identified in Portugal and now recognized in all continents. Over the past decade, thanks to the availability of the genetic test, our knowledge on the range of clinical expressions of this disorder has expanded, including different patterns and progression rates of the neuropathy, as well as aspects of the cardiomyopathy, which can be prominent. In the mean time, new tools are being developed to detect earlier TTR amyloid deposition such as cardiac scintigraphy with technetium-labelled pyrophosphate tracers or small nerve fiber alterations from skin biopsies, or using neurophysiological approaches as well as magnetic resonance neurography (MRN). Read More

    Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial.
    Lancet 2017 Dec 11. Epub 2017 Dec 11.
    Department of Hematology, Jagiellonian University, Krakow, Poland.
    Background: Bruton tyrosine kinase is a clinically validated target in mantle cell lymphoma. Acalabrutinib (ACP-196) is a highly selective, potent Bruton tyrosine kinase inhibitor developed to minimise off-target activity.

    Methods: In this open-label, phase 2 study, oral acalabrutinib (100 mg twice per day) was given to patients with relapsed or refractory mantle cell lymphoma, until disease progression or unacceptable toxicity. Read More

    Distinctive cutaneous and systemic features associated with specific antimyositis antibodies in adults with dermatomyositis: a prospective multicentric study of 117 patients.
    J Eur Acad Dermatol Venereol 2017 Dec 13. Epub 2017 Dec 13.
    Department of Dermatology, Saint-Eloi Hospital and Montpellier University Hospital, Montpellier, France.
    Background: Identification of myositis-specific autoantibodies (MSAs) for dermatomyositis (DM) could allow the characterization of an antibody-associated clinical phenotype.

    Objective: We sought to define the clinical phenotype of DM and the risk of cancer, interstitial lung disease (ILD) and calcinosis based on MSA.

    Methods: A 3. Read More

    ICCS/ESCCA consensus guidelines to detect GPI-deficient cells in paroxysmal nocturnal hemoglobinuria (PNH) and related disorders part 3 - data analysis, reporting and case studies.
    Cytometry B Clin Cytom 2018 Jan;94(1):49-66
    Federico II University and CEINGE Institute in Naples, Naples, Italy.
    Over the past several years, a diverse group of physicians and other laboratory scientists have developed various recommendations and guidelines regarding best practices for PNH testing. This manuscript is based on these previous recommendations as well as various other relevant publications of experts in the area of PNH testing. The goal is to provide flow cytometry laboratories with an updated consensus approach to analysis and reporting of PNH results and to address the most common analytical challenges for accurate reporting of this rare disease. Read More

    Comparison of 36 Gy, 20 Gy, or No Radiation Therapy After 6 Cycles of EBVP Chemotherapy and Complete Remission in Early-Stage Hodgkin Lymphoma Without Risk Factors: Results of the EORT-GELA H9-F Intergroup Randomized Trial.
    Int J Radiat Oncol Biol Phys 2017 Oct 27. Epub 2017 Oct 27.
    Centre de Traitement des Données du Cancéropôle Nord-Ouest, Centre François Baclesse, Caen, France. Electronic address:
    Purpose: While patients with early-stage Hodgkin lymphoma (HL) have an excellent outcome with combined treatment, the radiation therapy (RT) dose and treatment with chemotherapy alone remain questionable. This noninferiority trial evaluates the feasibility of reducing the dose or omitting RT after chemotherapy.

    Methods And Materials: Patients with untreated supradiaphragmatic HL without risk factors (age ≥ 50 years, 4 to 5 nodal areas involved, mediastinum-thoracic ratio ≥ 0. Read More

    Similar outcome of allogeneic stem cell transplantation after myeloablative and sequential conditioning regimen in patients with refractory or relapsed acute myeloid leukemia: A study from the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire.
    Am J Hematol 2018 Mar 8;93(3):416-423. Epub 2018 Jan 8.
    Hematology department, Hôpital Saint Louis, Paris, France.
    Patients with acute myeloid leukemia (AML) in relapse or refractory to induction therapy have a dismal prognosis. Allogeneic hematopoietic stem cell transplantation is the only curative option. In these patients, we aimed to compare the results of a myeloablative transplant versus a sequential approach consisting in a cytoreductive chemotherapy followed by a reduced intensity conditioning regimen and prophylactic donor lymphocytes infusions. Read More

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