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Br J Dermatol 2021 Jun 15. Epub 2021 Jun 15.

INSERM, Pierre Louis Institute for Epidemiology and Public Health, Assistance Publique - Hôpitaux de Paris (AP-HP). Sorbonne University, Pitié Salpêtrière Hospitals, Public Health Department, Pharmacoepidemiology Centre, CIC-1422, Paris, France.

Decision to initiate systemic therapy in psoriasis is mainly based on disease severity assessments, determined using physicians' derived scores, e.g. the Psoriasis Area and Severity Index (PASI), an absolute value of 10 or more indicates severe disease. Read More

Br J Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Dermatology department, AP-HP, Henri Mondor hospital, Créteil, France.

The prognosis of erythrodermic cutaneous T-cell lymphomas (ECTL) depends upon lymph node (N), visceral (M) involvement, and blood stage (B, i.e circulating Sézary cells, identified upon peripheral blood immunophenotyping, B0: absolute count <250/mm , B1: 250-1000/mm , and B2 stage, Sézary syndrome: ≥1000/mm ) with a 5-year overall survival of 36% for Sézary syndrome, the most common subtype of ECTL. Other prognostic markers include male sex, age >60 years, an elevated rate of lactate dehydrogenase (LDH), and histologic large-cell transformation (LCT). Read More

iScience 2021 Jun 10:102711. Epub 2021 Jun 10.

Vaccine Research Institute, Université Paris-Est Créteil, Faculté de Médecine, INSERM U955, Team 16, Créteil, France.

The identification of COVID-19 patients with high-risk of severe disease is a challenge in routine care. We performed cell phenotypic, serum and RNA-seq gene expression analyses in severe hospitalized patients (n = 61). Relative to healthy donors, results showed abnormalities of 27 cell populations and an elevation of 42 cytokines, neutrophil chemo-attractants, and inflammatory components in patients. Read More

Thorax 2021 Jun 14. Epub 2021 Jun 14.

Service de Pneumologie, Assistance Publique-Hôpitaux de Paris, Hôpital Tenon, Paris, France

Chronic interstitial lung abnormalities have been described in sickle cell disease (SCD) and attributed to repetitive episode of acute chest syndrome. We report a series of 22 cases of diffuse cystic lung disease in SCD with a case-control study to hunt for mechanism. On pathological analysis of a surgical lung biopsy of the index case, the bronchioles had the appearance of constrictive bronchiolitis. Read More

Hepatobiliary Pancreat Dis Int 2021 Jun 4. Epub 2021 Jun 4.

Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery, Queen Elizabeth University Hospitals Birmingham NHS Foundation Trust, B15 2TH, United Kingdom.

Background: Gold standard for colorectal liver metastases (CRLM) remains hepatic resection (HR). However, patients with severe comorbidities, unresectable or deep-situated resectable CRLM are candidates for ablation. The aim of the study was to compare recurrence rate and survival benefit of the microwave ablation (MWA), radiofrequency ablation (RFA) and HR by conducting the first network meta-analysis. Read More

Am J Kidney Dis 2021 Jun 10. Epub 2021 Jun 10.

Department of pathology, Center Hospitalier Universitaire de Nantes, Nantes; Centre de Recherche en Transplantation et en Immunologie, UMR 1064, INSERM, Université de Nantes. Electronic address:

Rationale & Objective: Pauci-immune necrotizing glomerulonephritis (PING) is usually associated with the presence of anti-neutrophil cytoplasm antibodies (ANCA). However, a minority (2-3%) of patients with PING do not have detectable ANCA. We aimed to assess the clinical spectrum and outcome of patients with ANCA-negative PING. Read More

Mult Scler Relat Disord 2021 May 8;53:103012. Epub 2021 May 8.

KTU Medical Faculty Farabi Hospital, Trabzon, Turkey.

Background: Natalizumab and fingolimod were the first preparations recommended for disease breakthrough in priorly treated relapsing-remitting multiple sclerosis. Of three published head-to-head studies two showed that natalizumab is the more effective to prevent relapses and EDSS worsening.

Methods: By re-analyzing original published results from MSBase, France, and Denmark using uniform methodologies, we aimed at identifying the effects of differences in methodology, in the MS-populations, and at re-evaluating the differences in effectiveness between the two drugs. Read More

Ther Adv Musculoskelet Dis 2021 28;13:1759720X211018605. Epub 2021 May 28.

U.O.S. of Rheumatology, Ospedale San Pietro Fatebenefratelli, Rome, Italy.

Viscosupplementation (VS) is a symptomatic treatment for knee and other joint osteoarthritis (OA). Despite a long history of use, conflicting opinions remain on the best clinical indications and the most appropriate patients to be treated with intra-articular hyaluronic acid (IA-HA), the optimal dosing regimen and the modalities of retreatment. A multidisciplinary committee of European experts on OA (EUROVISCO) was constituted to formulate recommendations, aimed at helping physicians in the decision-making and the optimal achievement of VS. Read More

Arch Cardiovasc Dis 2021 May 24. Epub 2021 May 24.

Hôpital Saint-Antoine, 75012 Paris, France. Electronic address:

Background: Although cardiovascular comorbidities seem to be strongly associated with worse outcomes in patients with coronavirus disease 2019 (COVID-19), data regarding patients with preexisting heart failure are limited.

Aims: To investigate the incidence, characteristics and clinical outcomes of patients with COVID-19 with a history of heart failure with preserved or reduced ejection fraction.

Methods: We performed an observational multicentre study including all patients hospitalized for COVID-19 across 24 centres in France from 26 February to 20 April 2020. Read More

Arch Cardiovasc Dis 2021 May 24. Epub 2021 May 24.

Fédération des services de cardiologie, faculté de médecine, Institute CARDIOMET, Université Paul Sabatier-Toulouse III, CHU de Toulouse-Rangueil, 31059 Toulouse, France; UMR UT3 CNRS 5288 Evolutionary Medicine, Obesity and Heart Failure: Molecular and Clinical Investigations, INI-CRCT F-CRIN, GREAT Networks, 31432 Toulouse, France.

Hemasphere 2021 Jun 1;5(6):e574. Epub 2021 Jun 1.

Service de Médecine Interne et Immunologie Clinique, Centre de Référence Constitutif des Cytopénies Auto-immunes de l'adulte, Centre Hospitalo-Universitaire Dijon Bourgogne, Université de Bourgogne Franche-Comté, Dijon, France.

Immune thrombocytopenia (ITP) is a rare autoimmune disease due to both a peripheral destruction of platelets and an inappropriate bone marrow production. Although the primary triggering factors of ITP remain unknown, a loss of immune tolerance-mostly represented by a regulatory T-cell defect-allows T follicular helper cells to stimulate autoreactive splenic B cells that differentiate into antiplatelet antibody-producing plasma cells. Glycoprotein IIb/IIIa is the main target of antiplatelet antibodies leading to platelet phagocytosis by splenic macrophages, through interactions with Fc gamma receptors (FcγRs) and complement receptors. Read More

ESC Heart Fail 2021 Jun 5. Epub 2021 Jun 5.

Department of Cardiology, Emergency Institute for Cardiovascular Diseases 'Prof. Dr. C. C. Iliescu', 3rd Cardiology Department, 258 Fundeni Street, Bucharest, 022328, Romania.

Cardiac amyloidosis is a restrictive cardiomyopathy determined by the accumulation of amyloid, which is represented by misfolded protein fragments in the cardiac extracellular space. The main classification of systemic amyloidosis is determined by the amyloid precursor proteins causing a very heterogeneous disease spectrum, but the main types of amyloidosis involving the heart are light chain (AL) and transthyretin amyloidosis (ATTR). AL, in which the amyloid precursor is represented by misfolded immunoglobulin light chains, can involve almost any system carrying the worst prognosis among amyloidosis patients. Read More

Eur J Neurol 2021 Jun 1. Epub 2021 Jun 1.

Neurology Department, APHP, CHU de Bicêtre, Le Kremlin-Bicêtre, 94276, France.

Introduction: Charcot-Marie-Tooth (CMT) disease, an untreatable hereditary polyneuropathy, may mimic chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), a treatable neuropathy.

Objective: In this retrospective study, we analyzed the characteristics of CMT patients misdiagnosed as CIDP in 16 University Hospitals from 3 countries, compared these patients with a reference group of CIDP patients, and estimated the cost of misdiagnosis.

Results: Amongst 1104 CIDP cases, we identified 35 CMT patients misdiagnosed as CIDP (3. Read More

Cognition 2021 May 29:104785. Epub 2021 May 29.

Département d'Etudes Cognitives, École normale supérieure, PSL University, 75005 Paris, France; Inserm U955, Institut Mondor de Recherche Biomédicale, Equipe E01 NeuroPsychologie Interventionnelle, 94000 Créteil, France; Université Paris-Est Créteil, Faculté de médecine, 94000 Créteil, France; Assistance Publique-Hôpitaux de Paris, National Reference Center for Huntington's Disease, Neurology Department, Henri Mondor-Albert Chenevier Hospital, Créteil, France. Electronic address:

More than a century ago, Broca (1861), Wernicke (1874) and Lichteim (1885) laid the foundations for the first anatomo-functional model of language, secondarily enriched by Geschwind (1967), leading to the Broca-Wernicke-Lichteim-Geschwind model. This model included the frontal, parietal, and temporal cortices as well as a subcortical structure, which could be the striatum, whose nature and role have remained unclear. Although the emergence of language deficits in patients with striatal injury has challenged the cortical language models developed over the past 30 years, the integration of the striatum into language processing models remains rare. Read More

Clin Microbiol Infect 2021 May 26. Epub 2021 May 26.

CHR Metz-Thionville, Service de Réanimation Polyvalente, Ars-Laquenexy, France.

Objectives: We evaluated the clinical, virological and safety outcomes of lopinavir/ritonavir, lopinavir/ritonavir-interferon (IFN)-β-1a, hydroxychloroquine or remdesivir in comparison to standard of care (control) in coronavirus 2019 disease (COVID-19) inpatients requiring oxygen and/or ventilatory support.

Methods: We conducted a phase III multicentre, open-label, randomized 1:1:1:1:1, adaptive, controlled trial (DisCoVeRy), an add-on to the Solidarity trial (NCT04315948, EudraCT2020-000936-23). The primary outcome was the clinical status at day 15, measured by the WHO seven-point ordinal scale. Read More

Amyloid 2021 May 27:1-10. Epub 2021 May 27.

Andrade's Center for Familial Amyloidosis, Porto, Portugal.

Background: Hereditary transthyretin (ATTRv) amyloidosis is a progressive multisystemic disease of adult-onset that arises from an inherited mutation in the transthyretin gene. Currently available disease severity and progression evaluation tools only cover one single organ or system, impacting data collection uniformity and its use in clinical settings.

Methods: The Jandhyala Method, including a systematic literature review and SMART interviews, was used to observe expert opinion from eight leaders in the treatment of ATTRv across Europe. Read More

Nat Commun 2021 05 25;12(1):3142. Epub 2021 May 25.

Neurimmune, Schlieren, Switzerland.

Transthyretin amyloid (ATTR) cardiomyopathy is a debilitating disease leading to heart failure and death. It is characterized by the deposition of extracellular ATTR fibrils in the myocardium. Reducing myocardial ATTR load is a therapeutic goal anticipated to translate into restored cardiac function and improved patient survival. Read More

Aliment Pharmacol Ther 2021 Jun;53(12):1323

Department of Gastroenterology, Henri Mondor Hospital, APHP, Paris Est-Créteil University (UPEC), Creteil, France.

Front Immunol 2021 5;12:689864. Epub 2021 May 5.

Univ Paris Est Creteil, INSERM, IMRB, Creteil, France.

World J Gastroenterol 2021 May;27(18):2205-2218

Unit of Hepato-Pancreatic-Biliary Surgery, "F. Miulli" General Regional Hospital, Acquaviva delle Fonti 70021, Italy.

Background: Surgical resection and radiofrequency ablation (RFA) represent two possible strategy in treatment of hepatocellular carcinoma (HCC) in Milan criteria.

Aim: To evaluate short- and long-term outcome in elderly patients (> 70 years) with HCC in Milan criteria, which underwent liver resection (LR) or RFA.

Methods: The study included 594 patients with HCC in Milan criteria (429 in LR group and 165 in RFA group) managed in 10 European centers. Read More

Neurophysiol Clin 2021 Jun 20;51(3):267-278. Epub 2021 May 20.

Univ Paris Est Creteil, EA4391, ENT, F-94010 Creteil, France; CH Sud-Seine-et-Marne, Pain Clinic (Centre d'Evaluation et Traitement de la Douleur), F-77140 Nemours, France.

Objective: The aim of this study was to determine if the use of postural insoles could result in a noticeable reduction in the foot pain intensity in patients with a chronic pain condition, either nociceptive (ankylosing spondylitis, AS) or neuropathic (small fiber neuropathy, SFN).

Method: In this open-label pilot study, patients were asked to wear postural insoles for a continuous period of 6 weeks. The primary endpoint was the mean daily pain intensity at foot mobilization measured using a visual analogue scale (VAS). Read More

BJS Open 2021 05;5(3)

Clinical Research Centre, Intercommunal Hospital of Créteil, Créteil, France.

Background: The COVID-19 pandemic has had a major impact on healthcare in many countries. This study assessed the effect of a nationwide lockdown in France on admissions for acute surgical conditions and the subsequent impact on postoperative mortality.

Methods: This was an observational analytical study, evaluating data from a national discharge database that collected all discharge reports from any hospital in France. Read More

BMC Med Educ 2021 May 18;21(1):284. Epub 2021 May 18.

Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d'ORL, d'otoneurochirurgie et de chirurgie cervico-faciale, 165 Chemin du Grand Revoyet, F-69495, Pierre-Bénite cedex, France.

Background: The ongoing COVID-19 pandemic has disrupted the surgical training of residents. There is a real concern that trainees will not be able to meet their training requirements. Low-fidelity surgical simulation appears to be an alternative for surgical training. Read More

Am J Hematol 2021 May 18. Epub 2021 May 18.

Département de Biochimie-Biologie Moléculaire, Pharmacologie, Génétique Médicale, AP-HP, Hôpitaux Universitaires Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, Créteil, Val-deMarne, France.

N Engl J Med 2021 May 16. Epub 2021 May 16.

From Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Cardiology, Hôpital Européen Georges Pompidou, Université de Paris, INSERM, Paris Centre de Recherche Cardiovasculaire (E.P., D.B., N.D.), AP-HP, Hôpital Saint Antoine, Department of Clinical Pharmacology and Unité de Recherche Clinique, Sorbonne Université, INSERM Unité 698 (T.S.), Université de Paris, INSERM Unité 1148, and Hôpital Bichat, AP-HP (P.G.S.), Sorbonne Université, ACTION Study Group, Institut de Cardiologie (AP-HP), INSERM UMRS 1166, Hôpital Pitié-Salpêtrière (G.M., J.S.), Clinical Research Unit Eco Ile de France, Hôpital Hôtel Dieu, AP-HP (I.D.-Z., A.B.), the Department of Cardiology, Hôpital Lariboisière, AP-HP, INSERM Unité 942, Université de Paris (J.-G.D.), the Department of Cardiology, Hôpital Bichat, AP-HP, French Alliance for Cardiovascular Trials, INSERM Unité 1148, Laboratory for Vascular Translational Science, Université de Paris (G.D.), the Clinical Research Unit and Centre d'Investigation Clinique 1418 INSERM, George Pompidou European Hospital, AP-HP (A.C.N., G. Chatellier), and the French Alliance for Cardiovascular Trials (E.P., T.S., P.G.S., G.L., D.B., G.D., N.D.), Paris, Centre Hospitalier Universitaire (CHU) de Nîmes, Nîmes (G. Cayla), Service de Cardiologie, AP-HP, Université de Paris Est Créteil, Hôpitaux Universitaires Henri Mondor, Créteil, and Unité 955-Mondor Institute for Biomedical Research, Equipe 03, INSERM, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort (R.G.), Hôpital du Bon Secours, Metz (K.K.), Clinique St. Martin (J.-F.M.) and the Cardiology Department, Caen University Hospital (V.R.), Caen, the Department of Cardiology, CHU Clermont-Ferrand, CNRS UMR 6602, Université Clermont Auvergne, Clermont-Ferrand, the Cardiac Intensive Care Unit, Heart and Lung Institute, CHU Lille (P.M.), and the Heart and Lung Institute, University Hospital of Lille, Institut Pasteur of Lille, INSERM Unité 1011 (G.L.), Lille, and the Intensive Cardiac Care Unit, Department of Cardiology, Rangueil University Hospital, and the Medical School, Toulouse III Paul Sabatier University, Toulouse (T.L.), Groupement de Coopération Saintaire de Cardiologie de la Côte Basque, Centre Hospitalier de la Côte Basque, Bayonne (J.-N.L.), the Cardiology Department, Hôpitaux de Chartres, Chartres (G.R.), and Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires, Equipe d'Accueil (EA 7460), University of Bourgogne Franche-Comté, and the Cardiology Department, University Hospital Center of Dijon Bourgogne, Dijon (Y.C.) - all in France; Cardiovascular Center Aalst, Aalst, Belgium (B.D.B.); and the Department of Cardiology, Lausanne University Center Hospital, Lausanne, Switzerland (B.D.B.).

Background: In patients with ST-elevation myocardial infarction (STEMI) who have multivessel disease, percutaneous coronary intervention (PCI) for nonculprit lesions (complete revascularization) is superior to treatment of the culprit lesion alone. However, whether complete revascularization that is guided by fractional flow reserve (FFR) is superior to an angiography-guided procedure is unclear.

Methods: In this multicenter trial, we randomly assigned patients with STEMI and multivessel disease who had undergone successful PCI of the infarct-related artery to receive complete revascularization guided by either FFR or angiography. Read More

Clin Infect Dis 2021 May 16. Epub 2021 May 16.

Virology Unit, Department of Prevention, Diagnosis and Treatment of Infections, Hôpital Henri Mondor (AP-HP), Université Paris-Est, Créteil, France.

We report an outbreak of SARS-CoV-2 501Y.V2 in a nursing home. All non-vaccinated residents (5/5) versus half of those vaccinated with BNT162b2 (13/26) were infected. Read More

PLoS One 2021 14;16(5):e0250676. Epub 2021 May 14.

Department of infectious diseases, Assistance Publique-Hôpitaux de Paris, Hôtel Dieu Hospital, Paris, France.

Background: Diabetes mellitus (DM) is a major and increasing public health problem that may be underdiagnosed and undertreated among persons living with HIV (PLWH).

Objective: To describe the diagnosis, treatment and follow-up of DM among PLWH.

Methods: This study was performed inside a monocentric cohort of 1494 PLWH. Read More

JAMA Netw Open 2021 May 3;4(5):e217039. Epub 2021 May 3.

Division of Medical Oncology and Hematology, Department of Medicine, University Health Network (UHN), Toronto, Ontario, Canada.

Importance: Adults with sickle cell disease (SCD) disproportionally experience early cognitive decline; however, guidance on the optimal screening strategy for cognitive dysfunction is lacking, and several available tools are biased by language, educational level, socioeconomic status, and race/ethnicity. The Rowland Universal Dementia Assessment Scale (RUDAS) was specifically designed for cognitive screening in multicultural populations.

Objective: To ascertain the prevalence of suspected dementia in adults with SCD using the RUDAS, and to identify whether age, sex, educational level, several biological variables, and SCD complications were associated with RUDAS scores. Read More

Am J Hematol 2021 May 10. Epub 2021 May 10.

INSERM 1266 Institut de Psychiatrie et Neurosciences de Paris - FHU Neurovasc-Paris Sorbonne, Paris, France.

In order to prevent stroke, screening for disease-related intracranial vasculopathy using Doppler ultrasound is recommended in sickle-cell disease (SCD) children. How to screen such vasculopathy in adults remains largely unknown. The objective of this study was to assess whether transcranial color-coded duplex sonography (TCCD) is sensitive and specific enough to identify SCD adult patients with vasculopathy, compared with magnetic resonance angiography (MRA). Read More

Int J Colorectal Dis 2021 May 7. Epub 2021 May 7.

University of Portsmouth, Portsmouth, UK.