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    Solar insolation in springtime influences age of onset of bipolar I disorder.
    Acta Psychiatr Scand 2017 Jul 19. Epub 2017 Jul 19.
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior University of California Los Angeles (UCLA), Los Angeles, CA, USA.
    Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder.

    Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Read More

    Laparoscopic Compared to Open Repeat Hepatectomy for Colorectal Liver Metastases: a Multi-institutional Propensity-Matched Analysis of Short- and Long-Term Outcomes.
    World J Surg 2017 Jul 17. Epub 2017 Jul 17.
    Institut Hospitalo-Universitaire (IHU), Institute for Minimally Hybrid Invasive Image-Guided Surgery, Université de Strasbourg, Strasbourg, France.
    Introduction: While uptake of laparoscopic hepatectomy has improved, evidence on laparoscopic re-hepatectomy (LRH) for colorectal liver metastases (CRLMs) is limited and has never been compared to the open approach. We sought to define outcomes of LRH compared to open re-hepatectomy (ORH).

    Methods: Patients undergoing re-hepatectomy for CRLM at 39 institutions (2006-2013) were identified. Read More

    European guideline for the management of pediculosis pubis.
    J Eur Acad Dermatol Venereol 2017 Jul 16. Epub 2017 Jul 16.
    Department of Dermatology II, Colentina Clinical Hospital, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
    Pediculosis pubis is caused by Phthirus pubis. The disease can be sexually transmitted. Patients main complain is of itch in the pubic area. Read More

    Central nervous system involvement in eosinophilic granulomatosis with polyangiitis (Churg-Strauss): Report of 26 patients and review of the literature.
    Autoimmun Rev 2017 Jul 12. Epub 2017 Jul 12.
    Department of Internal Medicine, Hôpital Cochin, F-75014 Paris, France; National Referral Center for Systemic and Autoimmune Diseases, Hôpital Cochin, F-75014 Paris, France; Université Paris Descartes, Faculté de Médecine Paris Descartes, F-75014 Paris, France; Université Paris Descartes, Paris 5, Paris, France; Inserm, U1016, Institut Cochin, F-75014 Paris, France. Electronic address:
    Background: Although peripheral nervous system involvement is common in eosinophilic granulomatosis with polyangiitis (EGPA), central nervous system (CNS) manifestations are poorly described. This study aimed to describe CNS involvement in EGPA.

    Patients And Methods: This retrospective, observational, multicenter study included patients with EGPA and CNS involvement affecting cranial nerves, brain and/or spinal cord. Read More

    Biologics in Myelodysplastic Syndrome-related Systemic Inflammatory and Autoimmune Diseases: French Multicenter Retrospective Study of 29 Patients.
    Autoimmun Rev 2017 Jul 10. Epub 2017 Jul 10.
    Service de Médecine Interne, Hôpital Saint Antoine, APHP, Université Paris 6, 75012 Paris, France.
    Background: Systemic inflammatory and autoimmune diseases (SIADs) associated with myelodysplastic syndromes are often difficult to treat. Corticosteroids are efficient but only usually at high doses. The use of biologics needs to be specified. Read More

    A FDG-PET driven consolidation strategy in diffuse large B-cell lymphoma: Final results of a randomized phase II study.
    Blood 2017 Jul 12. Epub 2017 Jul 12.
    Department of hematology, Hopital Claude Huriez, Univ. Lille, EA 7365, Groupe de Recherche sur les formes Injectables et les Technologies Associees, Lille, France.
    Dose-dense induction and upfront consolidation with autologous stem cell transplantation (ASCT) remain controversial issues when treating high-risk diffuse large B cell lymphoma patients. GELA designed a randomized phase II trial evaluating the efficacy of either R-ACVBP or R-CHOP14 induction and a PET-driven ASCT or standard immunochemotherapy (SIC) consolidation in aaIPI2-3 patients. PET was done at baseline, after 2 (PET2) and 4 induction cycles (PET4) and centrally assessed using international harmonization project (IHP) criteria. Read More

    Histiocytic and dendritic cell neoplasms: what have we learnt by studying 67 cases.
    Virchows Arch 2017 Jul 10. Epub 2017 Jul 10.
    Institute of Pathology and Neuropathology and Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany.
    Tumors derived from histiocytic and dendritic cells encompass a large and heterogeneous group of neoplastic and reactive conditions, and their diagnosis is challenging both for pathologists and clinicians. Diagnosis is based on morphological and phenotypical findings, but hybrid features are not uncommon. Furthermore, recent studies uncovered the molecular mechanisms driving some of these tumors, improving diagnostic adequacy, and providing the basis for effective therapeutic breakthroughs. Read More

    How to prevent relapse after allogeneic hematopoietic stem cell transplantation in patients with acute leukemia and myelodysplastic syndrome.
    Curr Res Transl Med 2017 Jul 4. Epub 2017 Jul 4.
    American university of Beirut, medical center, 113-6044 Beirut, Lebanon.
    Disease relapse remains the first cause of mortality of hematological malignancies after allogeneic hematopoietic stem cell transplantation (allo-HCT). The risk of recurrence is elevated in acute myeloid leukemia (AML) patients with high-risk cytogenetic or molecular abnormalities, as well as when allo-HCT is performed in patients with refractory hematological malignancies or with persistent molecular or radiological (PET-CT scan) residual disease. For high risk AML and myelodysplasia (MDS), a post transplant maintenance strategy is possible, using hypomethylating agents or tyrosine kinase inhibitors (TKI) anti-FLT3 when the target is present. Read More

    Stenting or Surgery for De Novo Common Femoral Artery Stenosis.
    JACC Cardiovasc Interv 2017 Jul;10(13):1344-1354
    CHU Brest, service de chirurgie vasculaire, Brest, France.
    Objectives: The TECCO (Traitement des Lésions Athéromateuses de l'Artère Fémorale Commune par Technique Endovasculaire Versus Chirurgie Ouverte [Endovascular Versus Open Repair of the Common Femoral Artery]) trial is a randomized comparison of safety and efficacy of stenting versus open surgery for de novo common femoral artery (CFA) stenosis.

    Background: Surgery for CFA lesions is considered effective and durable. Despite the widespread use of endovascular repair for infrainguinal disease, the value of this procedure for such lesions is uncertain. Read More

    Association Between Motor Symptoms and Brain Metabolism in Early Huntington Disease.
    JAMA Neurol 2017 Jul 3. Epub 2017 Jul 3.
    Commissariat à l'Energie Atomique et aux Energies Alternatives, Département des Sciences du Vivant, Institut d'Imagerie Biomédicale, MIRCen, Fontenay-aux-Roses, France2Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud, Université Paris-Saclay, UMR 9199, Neurodegenerative Diseases Laboratory, Fontenay-aux-Roses, France12NeurATRIS, Fontenay-aux-Roses, France14Faculté de Médecine, Université Paris Est-Créteil, Créteil, France16Centre Expert Parkinson, CHU Henri Mondor, Créteil, France.
    Importance: Brain hypometabolism is associated with the clinical consequences of the degenerative process, but little is known about regional hypermetabolism, sometimes observed in the brain of patients with clinically manifest Huntington disease (HD). Studying the role of regional hypermetabolism is needed to better understand its interaction with the motor symptoms of the disease.

    Objective: To investigate the association between brain hypometabolism and hypermetabolism with motor scores of patients with early HD. Read More

    Opposite effects of l-dopa and DBS-STN on saccadic eye movements in advanced Parkinson's disease.
    Neurol Neurochir Pol 2017 Jun 24. Epub 2017 Jun 24.
    Department of Neurology, Jagiellonian University, Medical College, Kraków, Poland.
    Objective: To assess the effects of l-dopa and deep brain stimulation of the subthalamic nucleus (DBS-STN) on saccadic eye movements in patients with Parkinson's disease (PD).

    Methods: Visually and internally guided horizontal saccades were evaluated using a saccadometer in 64 patients with advanced PD and 48 healthy controls. Forty-four pharmacologically treated patients were assessed in their "med-off" (OFF) and "med-on" (ON) status, whereas 20 DBS-STN treated patients were assessed in their "med-off, stim-off" (OFF) and "med-off, stim-on" (ON) status. Read More

    Management of delayed hemolytic transfusion reaction in sickle cell disease: Prevention, diagnosis, treatment.
    Transfus Clin Biol 2017 Jun 29. Epub 2017 Jun 29.
    Unité Inserm U955, équipe 2, laboratoire d'excellence GR-Ex-UPEC, Créteil, France; Centre de référence des syndromes drépanocytaires majeurs, groupe hospitalier Henri-Mondor-Albert-Chenevier, assistance publique-hôpitaux de Paris, Créteil, France.
    Transfusion remains a key treatment of sickle cell disease complications. However, delayed hemolytic transfusion reaction, the most serious complication of transfusion, may be life-threatening if hyperhemolysis develops. This syndrome is generally underdiagnosed because its biological and clinical features resemble those of vaso-occlusive crisis, and red blood cell antibodies are frequently absent. Read More

    Change in Coefficient of Fatigability Following Rapid, Repetitive Movement Training in Post-Stroke Spastic Paresis: A Prospective Open-Label Observational Study.
    J Stroke Cerebrovasc Dis 2017 Jun 27. Epub 2017 Jun 27.
    "Physical Medicine and Rehabilitation" Unit, "OORR Hospital," University of Foggia, Foggia, Italy; "Fondazione Turati" Rehabilitation Centre, Vieste, Foggia, Italy. Electronic address:
    Background: In post-stroke patients, the possibility of performing an active ankle dorsiflexion movement is favorable for the recovery of gait. Moreover, the fatigue due to repetitive active ankle dorsiflexion could reduce the speed gait. We assessed the change in coefficient of fatigability of active ankle dorsiflexion after a home-based self-rehabilitative procedure in post-stroke patients. Read More

    Electroretinogram Findings in Early-Stage Sickle Cell Retinopathy According to Hemoglobin Type.
    Invest Ophthalmol Vis Sci 2017 Jun;58(7):3262-3267
    Department of Ophthalmology, Centre Hospitalier Intercommunal, Créteil, France.
    Purpose: Although extensive clinical research has been performed on structural analysis of sickle cell (SC) retinopathy, functional aspects have been poorly investigated. Our purpose was to report full-field electroretinogram (ffERG) findings in patients with early SC retinopathy according to the following hemoglobin types: HbSS or HbSC (homozygous or heterozygous mutations, respectively).

    Methods: In this monocentric retrospective observational study, patients affected by nonproliferative SC retinopathy were included from November 2014 to April 2016. Read More

    Cigarette smoking and schizophrenia: a specific clinical and therapeutic profile? Results from the FACE-Schizophrenia cohort.
    Prog Neuropsychopharmacol Biol Psychiatry 2017 Jun 26. Epub 2017 Jun 26.
    AP-HP, Department of Psychiatry, Louis Mourier Hospital, Colombes, Inserm U894, Université Paris Diderot, Sorbonne Paris Cité, Faculté de médecine, France; Service de psychiatrie d'adulte, Centre Hospitalier de Versailles, UFR des Sciences de la Santé Simone Veil, Université Versailles Saint-Quentin en Yvelines, Versailles, France.
    Background: Tobacco use is common in patients with schizophrenia (SZ) but little is known on the role of tobacco in the physiopathology or on the course of the disease. Only few studies embrace an extensive examination of clinical and therapeutic characteristics in stabilized patients. The objective of the present study was to determine the prevalence of tobacco smoking in stabilized SZ outpatients and the clinical and treatment characteristics associated with daily tobacco use in a large community-dwelling sample of patients. Read More

    Epidemiology of fragile skin: Internet-based surveys in Mexico and Russia.
    Clin Cosmet Investig Dermatol 2017 10;10:221-228. Epub 2017 Jun 10.
    Department of Cancer, Immunity, Transplantation and Infections, Hôpital Henri Mondor (APHP), University Paris Est Créteil, Créteil, France.
    Background: Fragile skin is a poorly understood skin condition, particularly in the general adult population. There are currently limited epidemiological data on the prevalence of fragile skin in adults. The objectives of this study were to assess the prevalence of perceived fragile skin across different skin types in representative samples of the general adult populations in Mexico and Russia, and to identify skin characteristics associated with perceived fragile skin. Read More

    Plasma concentrations of atovaquone given to immunocompromised patients to prevent Pneumocystis jirovecii.
    J Antimicrob Chemother 2017 Jun 22. Epub 2017 Jun 22.
    Assistance Publique-Hôpitaux de Paris (AP-HP), Henri Mondor Teaching Hospital, Department of Haematology, Créteil, France.
    Objectives: Atovaquone is one of the alternatives to trimethoprim/sulfamethoxazole for prophylaxis of Pneumocystis jirovecii pneumonia (PCP) in immunocompromised patients. In volunteers, there was wide inter-individual variability in atovaquone bioavailability. The aim of this study was to assess the plasma concentrations of atovaquone in immunocompromised patients under PCP prophylaxis. Read More

    Association of increased genotypes risk for bipolar disorder with brain white matter integrity investigated with tract-based spatial statistics: Special Section on "Translational and Neuroscience Studies in Affective Disorders". Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summarise relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders.
    J Affect Disord 2017 Oct 15;221:312-317. Epub 2017 Jun 15.
    Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy; Department of Psychiatry and Behavioural Neurosciences, University of Texas at Houston, TX, USA. Electronic address:
    Background: Diffusion tensor imaging (DTI) studies, which allow the in-vivo investigation of brain tissue integrity, have shown that bipolar disorder (BD) patients present signs of white matter dysconnectivity. In parallel, genome-wide association studies (GWAS) identified several risk genetic variants for BD.

    I Methods: In this mini-review, we summarized DTI studies coupling tract-based spatial statistics (TBSS), a reliable technique exploring white matter axon bundles, and genetics in BD. Read More

    Is bilateral internal thoracic artery grafting a safe option for chronic dialysis patients?
    Arch Cardiovasc Dis 2017 Jun 16. Epub 2017 Jun 16.
    Cardiovascular department, Ospedali Riuniti and university of Trieste, Trieste, Italy.
    Background: The use of bilateral internal thoracic artery (BITA) grafting has been proposed for dialysis patients with multivessel coronary artery disease, primarily because of hypothetical long-term survival benefits.

    Aims: To investigate the outcome of BITA grafting in dialysis patients.

    Methods: This was a retrospective analysis of the use of BITA grafting in 105 consecutive patients with end-stage renal failure on chronic dialysis in three European centres with extensive experience in BITA. Read More

    ZOHé: A Prospective Study of the Use of Biosimilar Filgrastim Zarzio in Clinical Practice in Patients Treated With Chemotherapy for Lymphoid Malignancies.
    Clin Lymphoma Myeloma Leuk 2017 Jun 10;17(6):362-369.e2. Epub 2017 May 10.
    Institut de Cancérologie de l'Ouest René Gauducheau, Saint Herblain, France. Electronic address:
    Background: The ZOHé study was a prospective, observational, multicenter study in France to assess use of biosimilar filgrastim Zarzio in routine clinical practice in patients undergoing neutropenia-inducing chemotherapy.

    Patients And Methods: Patients ≥ 18 years undergoing chemotherapy for a malignant disease and with a first prescription for Zarzio were enrolled in 2 cohorts: solid tumor (1174 patients) or hematological malignancy (633 patients); the latter is reported here. Analyses primarily described the prescription and use of Zarzio in current practice, and included identification of factors linked to prescription for primary prophylaxis, comparison of use in relation to European Organisation for the Research and Treatment of Cancer (EORTC) guidelines, and estimation of chemotherapy dose intensity maintenance in patients given Zarzio. Read More

    The Clinical Picture of Severe Systemic Capillary-Leak Syndrome Episodes Requiring ICU Admission.
    Crit Care Med 2017 Jul;45(7):1216-1223
    1Service de Médecine Interne 2, Centre Hospitalier Universitaire (CHU) La Pitié-Salpêtrière, Université Paris 6, APHP, Paris, France.2Service de Réanimation Médicale, CHU La Pitié-Salpêtrière, Université Paris 6, APHP, Paris, France.3Service de Réanimation Médicale, CHU d'Angers, Angers, France.4Service de Médecine Interne, CH Bretagne Atlantique, Vannes, France.5Service de Réanimation Médicale, CHU Edouard-Herriot, Lyon, France.6Service de Réanimation, CHU Lyon-Sud, Pierre-Bénite, France.7Service de Réanimation Polyvalente, CH Pierre Oudot, Bourgoin Jallieu, France.8Service de Réanimation Médicale, CHRU Lille, Lille, France.9Service de Réanimation Médicale, CHU Bichat, APHP, Paris, France.10Service de Réanimation Polyvalente, Hôpital Delafontaine, Saint-Denis, France.11Service de Réanimation Polyvalente, CH André-Mignot, Le Chesnay, France.12Service de Réanimation Médicale, CHU Hôtel-Dieu, Nantes, France.13Service de Réanimation Médicale, CHU Henri-Mondor, APHP, Créteil, France.14Service de Pneumologie et de Réanimation Médicale, CHU La Pitié-Salpêtrière, APHP, Paris, France.15Service de Réanimation Chirurgicale, CHU Lyon-Est, Hôpital Louis-Pradel, Bron, France.16Service de Réanimation Médicale, Hôpital Gabriel-Montpied, CHU Clermont-Ferrand, Clermont-Ferrand, France.17Service de Réanimation Polyvalente, CH Notre-Dame de la Miséricorde, Ajaccio, France.18Service de Réanimation Médicale, CHU Ambroise-Paré, APHP, Boulogne-Billancourt, France.19Service de Réanimation Médicale, CHU Grenoble, Grenoble, France.20Service de Réanimation Médicale, CHU Saint-Louis, APHP, Paris, France.21Service de Réanimation, Hôpital du Valais-Institut Central, Sion, Switzerland.22Service de Réanimation, Hôpital d'Instruction des Armées Desgenettes, Lyon, France.23Service de Réanimation Polyvalente, CH Foch, Suresnes, France.24Service de Réanimation, CH Dax, Dax, France.25Service de Réanimation Polyvalente, CH Bretagne Atlantique, Vannes, France.26Service de Réanimation Médicale, CHU Cochin, APHP, Paris, France.27Service de Réanimation Adulte, CHU Necker-Enfants Malades, APHP, Paris, France.
    Objective: Systemic capillary-leak syndrome is a very rare cause of recurrent hypovolemic shock. Few data are available on its clinical manifestations, laboratory findings, and outcomes of those patients requiring ICU admission. This study was undertaken to describe the clinical pictures and ICU management of severe systemic capillary-leak syndrome episodes. Read More

    Current and emerging treatments for vitiligo.
    J Am Acad Dermatol 2017 Jul;77(1):17-29
    Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts.
    Clinicians should be aware that vitiligo is not merely a cosmetic disease and that there are safe and effective treatments available for vitiligo. It is important to recognize common and uncommon presentations and those with active disease, as well as their implications for clinical management; these were discussed in the first article in this continuing medical education series. Existing treatments include topical and systemic immunosuppressants, phototherapy, and surgical techniques, which together may serve to halt disease progression, stabilize depigmented lesions, and encourage repigmentation. Read More

    New discoveries in the pathogenesis and classification of vitiligo.
    J Am Acad Dermatol 2017 Jul;77(1):1-13
    Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts.
    Vitiligo is a common autoimmune disease that progressively destroys melanocytes in the skin, resulting in the appearance of patchy depigmentation. This disfiguring condition frequently affects the face and other visible areas of the body, which can be psychologically devastating. The onset of vitiligo often occurs in younger individuals and progresses for life, resulting in a heavy burden of disease and decreased quality of life. Read More

    Clinical outcome of cystic fibrosis patients colonized by Scedosporium species following lung transplantation: A single-center 15-year experience.
    Transpl Infect Dis 2017 Jun 15. Epub 2017 Jun 15.
    Paris Descartes University, Paris, France.
    Background: Fungi of the genus Scedosporium are emerging pathogens responsible for severe infections in lung transplant recipients. These infections are associated with poor prognosis and some centers consider now Scedosporium species colonization as a contraindication to lung transplantation (LT) even though no published evidence demonstrates that Scedosporium species colonization is associated with higher morbidity or mortality after LT.

    Methods: Here we aim to describe characteristics and outcome of cystic fibrosis (CF) lung transplant recipients colonized with Scedosporium species in a single center over a 15-year period. Read More

    Impact of Routine Fractional Flow Reserve on Management Decision and 1-Year Clinical Outcome of Patients With Acute Coronary Syndromes: PRIME-FFR (Insights From the POST-IT [Portuguese Study on the Evaluation of FFR-Guided Treatment of Coronary Disease] and R3F [French FFR Registry] Integrated Multicenter Registries - Implementation of FFR [Fractional Flow Reserve] in Routine Practice).
    Circ Cardiovasc Interv 2017 Jun;10(6)
    From the Department of Cardiology, University Hospital, Lille, France (E.V.B., F.V.); INSERM U1011, Lille-II-University, France (E.V.B., F.V.); Hospital Fernando da Fonseca, Amadora, Portugal (S.-B.B.); Hospital de Santa Cruz - CHLO, Carnaxide, Portugal (L.R.); Statistical Department, St. Jude Medical Inc, St Paul, MN (J.H.); Hôpital Louis Pradel, Lyon, France (G.R.); INSERM 1060 CARMEN, Claude Bernard University Lyon, France (G.R.); Centro Hospitalar Vila Nova de Gaia, Portugal (L.S.); Clinique Sainte Clotilde, Saint Denis de la Réunion, France (C.P.); Hospital Santa Marta - Centro Hospitalar Lisboa Central, Lisboa, Portugal (R.R.); CHU La Timone, Marseille, France (T.C.); Hospital Garcia de Orta, Almada, Portugal (R.C.); CHU Mondor, Créteil, France (E.T.); Centro Hospitalar Universitário Coimbra, Portugal (E.J.); CH d'Annecy, France (L.B.); Hospital Divino Espirito Santo, Ponta Delgada, Portugal (C.M.); C.H.I.T.S. Hôpital Sainte Musse, Toulon, France (D.B.); Hospital Geral dos Covões - Centro Hospitalar Coimbra, Portugal (M.C.); Centre Hospitalier Haguenau, France (M.H.); Hospital Santa Maria - Centro Hospitalar Lisboa Norte, Portugal (E.O.); Hôpital de la Croix-Rousse, Lyon, France (C.B.); Hospital de Braga, Portugal (J.C.); Institut Pasteur de Lille-INSERM, France (J.D.); Hospital São Teotónio, Viseu, Portugal (J.P.); Hôpital Lariboisière, Paris, France (G.S.); Centro Hospitalar Setúbal, Portugal (N.F.); Centre Hospitalier Valence, France (C.B.); Hospital Santo André - Centro Hospitalar Leiria-Pombal, Portugal (J.G.); Hôpital Albert Schweizer, Colmar, France (N.L.); Hospital Dr. Nélio Mendonça, Funchal, Portugal (B.S.); Centre Hospitalier La Durance, Avignon, France (P.B.); Hospital Geral Santo António - Centro Hospitalar do Porto, Portugal (M.-J.S.); Centre Hospitalier Amiens Sud, Amiens, France (L.L.); Centro Hospitalar São João, Porto, Portugal (J.C.S.); Centro Hospitalar Tâmega e Sousa, Penafiel, Portugal (A.R.); Centro Hospitalar Trás-os-Montes e Alto Douro - Unidade Hospitalar Vila Real, Portugal (L.S.); Hospital Espírito Santo, Évora, Portugal (R.F.); and Hopital Privé d'Antony, France (P.D.).
    Background: Fractional flow reserve (FFR) is not firmly established as a guide to treatment in patients with acute coronary syndromes (ACS). Primary goals were to evaluate the impact of integrating FFR on management decisions and on clinical outcome of patients with ACS undergoing coronary angiography, as compared with patients with stable coronary artery disease.

    Methods And Results: R3F (French FFR Registry) and POST-IT (Portuguese Study on the Evaluation of FFR-Guided Treatment of Coronary Disease), sharing a common design, were pooled as PRIME-FFR (Insights From the POST-IT and R3F Integrated Multicenter Registries - Implementation of FFR in Routine Practice). Read More

    Factors associated with the choice of the first biologic in psoriasis: real-life analysis from the Psobioteq cohort.
    J Eur Acad Dermatol Venereol 2017 Jun 13. Epub 2017 Jun 13.
    Département de Dermatologie, AP-HP, Hôpitaux Universitaires Henri Mondor, UPEC, Créteil, France.
    Background: Decision-making is a complex process. The aim of our study was to assess factors associated with the choice of the first biological treatment in patients with moderate-to-severe psoriasis.

    Methods: Data on all patients included in the French prospective, observational, cohort, Psobioteq and initiating a first biologic prescription between July 2012 and July 2016 were analysed. Read More

    Sorafenib vs surgical resection for hepatocellular carcinoma with macrovascular invasion: A propensity score analysis.
    Liver Int 2017 Jun 13. Epub 2017 Jun 13.
    Centre Hepato Biliaire, Assistance Publique Hôpitaux de Paris, Hôpital Paul Brousse, Villejuif, France.
    Background & Aim: Sorafenib is the standard of care for patients with hepatocellular carcinoma (HCC) and macrovascular invasion (MVI), with limited survival. Retrospective surgical studies have reported prolonged survival in this situation. This study aimed to compare the overall survival of patients with HCC and MVI treated with surgical resection or sorafenib. Read More

    How your ears can tell what is hidden in your heart: wild-type transthyretin amyloidosis as potential cause of sensorineural hearing loss inelderly-AmyloDEAFNESS pilot study.
    Amyloid 2017 Jun 9:1-5. Epub 2017 Jun 9.
    a School of Medicine , University Paris-Est Creteil (UPEC) , Créteil , France.
    Background: Wild-type transthyretin amyloidosis (ATTRwt) is an age-related life-threatening condition. Prognosis is mainly dependent on cardiac involvement. Other organs and tissues may be affected. Read More

    Fine-Scale Structure Analysis Shows Epidemic Patterns of Clonal Complex 95, a Cosmopolitan Escherichia coli Lineage Responsible for Extraintestinal Infection.
    mSphere 2017 May-Jun;2(3). Epub 2017 May 31.
    UMR 1137 INSERM and Université Paris Diderot, IAME, Sorbonne Paris Cité, Paris, France.
    The Escherichia coli lineage known as clonal complex 95 (CC95) is a cosmopolitan human-associated lineage responsible for a significant fraction of extraintestinal infections of humans. Whole-genome sequence data of 200 CC95 strains from various origins enabled determination of the CC95 pangenome. The pangenome analysis revealed that strains of the complex could be assigned to one of five subgroups that vary in their serotype, extraintestinal virulence, virulence gene content, and antibiotic resistance gene profile. Read More

    Severe varicella-zoster virus pneumonia: a multicenter cohort study.
    Crit Care 2017 Jun 7;21(1):137. Epub 2017 Jun 7.
    Service de réanimation médicale, Hôpital Saint-Louis, AP-HP, Paris, France.
    Background: Pneumonia is a dreaded complication of varicella-zoster virus (VZV) infection in adults; however, the data are limited. Our objective was to investigate the clinical features, management, and outcomes of critically ill patients with VZV-related community-acquired pneumonia (VZV-CAP).

    Methods: This was an observational study of patients with VZV-CAP admitted to 29 intensive care units (ICUs) from January 1996 to January 2015. Read More

    Randomized comparison of liposomal amphotericin B versus placebo to prevent invasive mycoses in acute lymphoblastic leukaemia.
    J Antimicrob Chemother 2017 May 30. Epub 2017 May 30.
    Department of Medicine II, University Hospital, Goethe University, Frankfurt, Germany.
    Objectives: To prevent invasive fungal disease (IFD) in adult patients undergoing remission-induction chemotherapy for newly diagnosed acute lymphoblastic leukaemia (ALL).

    Patients And Methods: In a double-blind multicentre Phase 3 study, patients received prophylactic liposomal amphotericin B (L-AMB) at 5 mg/kg intravenously or placebo twice weekly in a 2:1 random allocation during remission-induction treatment. The primary endpoint was the development of proven or probable IFD. Read More

    B cell lymphomas with discordance between pathological features and clinical behavior.
    Virchows Arch 2017 Jun 1. Epub 2017 Jun 1.
    Department of Pathology, Royal Marsden Hospital, London, Sutton, UK.
    B-cell lymphomas encompass a large number of disease entities clinically ranging from indolent to aggressive. The defining pathological features usually predict clinical course, with small and large B-cell lymphomas correlating to low-grade vs high-grade features, but discordant situations may be encountered. Two sessions of the workshop of the XVIII meeting of the European Association for Haematopathology (EAHP) held in Basel in 2016 addressed this topic. Read More

    Usual and unusual pitfalls of 18F-FDG-PET/CT in lymphoma after treatment: a pictorial review.
    Nucl Med Commun 2017 Jul;38(7):563-576
    Department of aNuclear Medicine, University of Claude Bernard Lyon 1 bHematology, Hospices Civils de Lyon, Lyon cDepartment of Nuclear Medicine Hôpital Privé du Confluent, Nantes dDepartment of Nuclear Medicine eDepartment of Radiopharmacy, Grenoble University Hospital, Grenoble fDepartment of Nuclear Medicine, Centre Hospitalier Henri Mondor, Créteil, France gDepartment of Nuclear Medicine and Diagnostic Imaging Section, International Atomic Energy Agency, Vienna, Austria.
    Fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) is now a standard of care in initial staging and treatment evaluation of lymphomas. It is also used in the interim evaluation in diffuse large B cell lymphoma and Hodgkin lymphoma. However, several pitfalls may occur during or after treatment, because of the nonspecificity of F-FDG for lymphoma disease and treatment as immunotherapy, thus possibly induces misinterpretation and wrong treatment decision. Read More

    Lymphomatoid papulosis associated with chronic lymphocytic leukemia/small lymphocytic lymphoma: 3 cases.
    Br J Dermatol 2017 Jun 1. Epub 2017 Jun 1.
    Department of Dermatology, AP-HP, St Louis Hospital, Paris 7 University, Paris, France.
    Lymphomatoid papulosis (LyP) is considered as an indolent CD30+ lymphoproliferative cutaneous disorder. (1,2) Nevertheless, 10%-20% up to 50% of patients with LyP have coexistent lymphoma. (1, 3-7) The most frequently associated malignancies are mycosis fungoides, primary cutaneous anaplastic large cell lymphoma, or Hodgkin's disease. Read More

    [Multiple sclerosis fatigue, its neural correlates, and its modulation with tDCS].
    Fortschr Neurol Psychiatr 2017 May 23;85(5):260-269. Epub 2017 May 23.
    Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum der Universität München.
    Multiple sclerosis (MS) is a chronic progressive and inflammatory disease of the central nervous system and causes high rates of non-traumatic disability in young adults. Fatigue is frequently reported by a major part of patients during the disease course and dramatically increases the burden of illness. Despite the high prevalence of fatigue and its enormous impact on quality of life, its pathophysiological mechanisms are still unclear. Read More

    Genome-wide association study of erythrocyte density in sickle cell disease patients.
    Blood Cells Mol Dis 2017 Jun 13;65:60-65. Epub 2017 May 13.
    Faculty of Medicine, Program in Bioinformatics, Université de Montréal, Montreal, Quebec, Canada; Montreal Heart Institute, Montreal, Quebec, Canada. Electronic address:
    Deoxy-hemoglobin S polymerization into rigid fibers is the direct cause of the clinical sequelae observed in sickle cell disease (SCD). The rate of polymerization of sickle hemoglobin is determined primarily by intracellular hemoglobin concentration, itself dependent on the amount of sickle hemoglobin and on red blood cell (RBC) volume. Dense, dehydrated RBC (DRBC) are observed in SCD patients, and their number correlates with hemolytic parameters and complications such as renal dysfunction, leg ulcers and priapism. Read More

    From open to large-scale randomized cell transplantation trials in Huntington's disease: Lessons from the multicentric intracerebral grafting in Huntington's disease trial (MIG-HD) and previous pilot studies.
    Prog Brain Res 2017 23;230:227-261. Epub 2017 Feb 23.
    Assistance Publique-Hôpitaux de Paris, Centre de Référence Maladie de Huntington, Service de Neurologie, Hôpital Henri Mondor-Albert Chenevier, Créteil, France; INSERM U955, Equipe 01 Neuropsychologie Interventionnelle, Créteil, France; Département d'Etudes Cognitives, Ecole Normale Supérieure, PSL* Research University, Paris, France; Université Paris Est, Faculté de Médecine, Créteil, France. Electronic address:
    Fifty-one patients from open-label pilot trials have been transplanted in Huntington's disease (HD) using human fetal cells; clinical data and follow-up are available in 30 of them. These open-label studies were mostly designed for safety and feasibility. However, signs of long-term efficacy have been reported in 4 out of 30 patients, differences in tissue preparation, surgical procedure, patients characteristics, immunosuppression regimens, clinical, and imaging assessments, makes it difficult to define the optimal procedure for future trials. Read More

    Metastatic chromophobe renal cell carcinoma treated with targeted therapies: A Renal Cross Channel Group study.
    Eur J Cancer 2017 Jul 23;80:55-62. Epub 2017 May 23.
    Medical Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France. Electronic address:
    Background: Treatment of non-clear cell renal cell carcinoma (RCC) remains controversial despite several recent prospective studies of targeted therapies (TT). Often Vascular Endothelial growth Factor (VEGF) and Mammalian Target of Rapamycin (mTOR) inhibitors are used, extrapolating the data from use of these agents in clear cell RCC.

    Methods: We performed a retrospective data analysis within the Renal Cross Channel Group to determine metastatic chromophobe RCC (mChRCC) outcomes in the TT era. Read More

    Seasonal pattern in bipolar disorders and cardio-vascular risk factors: A study from the FACE-BD cohort.
    Chronobiol Int 2017 May 24:1-10. Epub 2017 May 24.
    a AP-HP, GH Saint-Louis - Lariboisière - F. Widal , Département de Psychiatrie et de Médecine Addictologique , Paris , France.
    Seasonal pattern (SP) and metabolic syndrome (MetS) are major contributors to poor outcome in bipolar disorders (BD). Patients with seasonal bipolar depression present increased appetite, carbohydrate cravings, weight gain, and hypersomnia, which can increase the development of MetS. MetS also appears to be associated with seasonal mood changes in the general population. Read More

    Immediate hypersensitivity reaction to pegylated liposomal doxorubicin: management and outcome in four patients.
    Eur J Dermatol 2017 Jun;27(3):271-274
    Department of Dermatology, Saint-André Hospital CHU Bordeaux, Bordeaux, France, INSERM U1053, Bordeaux Research in Translational Oncology University Bordeaux, Bordeaux, France, French Study Group of Cutaneous Lymphoma (GFELC).
    Hypersensitivity reactions (HSR) to pegylated liposomal doxorubicin (PLD; Caelyx(®)) have been reported, and symptoms usually resolve with drug withdrawal. However, the risk of relapse of severe HSR and prevention remain poorly described. To report the management and outcome in four patients with HSR due to PLD. Read More

    Dermatitis herpetiformis and bone mineral density: analysis of a French cohort of 53 patients.
    Eur J Dermatol 2017 May 19. Epub 2017 May 19.
    Assistance Publique-Hôpitaux de Paris (APHP), Department of Dermatology, Henri Mondor Hospital, Créteil, France, EA 7379 EpiDermE (Epidémiologie en Dermatologie et Evaluation des Thérapeutiques), UPEC, Créteil, France, Université Paris-Est Créteil Val de Marne (UPEC), Créteil, France, Centre d'Investigation Clinique 1430, AP-HP, Créteil, France.
    The characteristics of patients with dermatitis herpetiformis (DH) in France is poorly documented. Furthermore, the risk of fractures and bone mineral density (BMD) in DH remain under-described, and recommendations for systematic screening for osteoporosis in DH are lacking. To describe the characteristics of DH in a large French cohort and evaluate the association between BMD and features of osteoporosis. Read More

    Diabetes and male sex are key risk factor correlates of the extent of coronary artery calcification: A Euro-CCAD study.
    J Diabetes Complications 2017 Jul 31;31(7):1096-1102. Epub 2017 Mar 31.
    Department of Public Health and Clinical Medicine, Umeå University and Heart Centre, Umeå, Sweden. Electronic address:
    Background And Aims: Although much has been written about the conventional cardiovascular risk factor correlates of the extent of coronary artery calcification (CAC), few studies have been carried out on symptomatic patients. This paper assesses the potential ability of risk factors to associate with an increasing CAC score.

    Methods: From the European Calcific Coronary Artery Disease (Euro-CCAD) cohort, we retrospectively investigated 6309 symptomatic patients, 62% male, from Denmark, France, Germany, Italy, Spain and the USA. Read More

    Loss of SMARCE1 expression is a specific diagnostic marker of clear cell meningioma: a comprehensive immunophenotypical and molecular analysis.
    Brain Pathol 2017 May 5. Epub 2017 May 5.
    Department of Neuropathology, Sainte-Anne Hospital, 75014, Paris, France.
    Clear cell meningioma (CCM) is a rare grade II histopathological subtype that usually occurs in young patients and displays high recurrence rate. Germline SMARCE1 mutations have been described in hereditary forms of this disease and more recently in small syndromic and sporadic CCM series. The diagnostic value of SMARCE1 in distinguishing between CCM and other meningioma variants has not been yet established. Read More

    Airborne allergic contact dermatitis caused by isothiazolinones in water-based paints: a retrospective study of 44 cases.
    Contact Dermatitis 2017 Apr 27. Epub 2017 Apr 27.
    Dermatology and Allergology Department, Tenon Hospital (AP-HP), Sorbonne Universities, UPMC University Paris 06, 75020, Paris, France.
    Background: Airborne allergic contact dermatitis caused by paints containing isothiazolinones has been recognized as a health hazard.

    Objectives: To collect epidemiological, clinical and patch test data on airborne allergic contact dermatitis caused by isothiazolinone-containing paints in France and Belgium.

    Methods: A descriptive, retrospective study was initiated by the Dermatology and Allergy Group of the French Society of Dermatology, including methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI)- and/or MI-sensitized patients who developed airborne allergic contact dermatitis following exposure to isothiazolinone-containing paint. Read More

    Neuroimaging findings of postnatally acquired Zika virus infection: a pictorial essay.
    Jpn J Radiol 2017 Jul 26;35(7):341-349. Epub 2017 Apr 26.
    Department of Radiology, CDPI/DASA, Américas Medical City, Rio De Janeiro, RJ, Brazil.
    Zika virus (ZIKV) is a mosquito-borne arbovirus from the Flaviviridae family, first discovered in 1947. There has been no report of severe complications caused by this virus in humans until recently. However, it is confirmed now that prenatally acquired ZIKV infection may cause severe congenital brain abnormalities in the infected fetuses. Read More

    History of clubfoot treatment, part I: From manipulation in antiquity to splint and plaster in Renaissance before tenotomy.
    Int Orthop 2017 Apr 26. Epub 2017 Apr 26.
    Hopital Europeen Georges Pompidou, 75015, Paris, France.
    Idiopathic clubfoot is one of the most common problems in paediatric orthopaedics. The treatment is controversial and continues to be one of the challenges in paediatric orthopaedics. The aim of this review is to assess the different methods of clubfoot treatment used over the years in light of the documentation present in the literature and art paintings from the antiquity to the end of the 19th century. Read More

    ICU Patients Requiring Renal Replacement Therapy Initiation: Fewer Survivors and More Dialysis Dependents From 80 Years Old.
    Crit Care Med 2017 Aug;45(8):e772-e781
    1Réanimation Médicale, Hôpital Henri Mondor-APHP, Créteil, France.2Réanimation Médicale, Hôpital Européen Georges Pompidou-APHP, Paris, France.3Unité de recherche clinique, Hôpital Européen Georges Pompidou-APHP, Paris, France.4INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.
    Objectives: To assess the role of advanced age on survival and dialysis dependency after initiation of renal replacement therapy for acute kidney injury.

    Design: Retrospective pooled analysis of prospectively collected data.

    Setting: ICUs of two teaching hospitals in Paris area, France. Read More

    A randomized, double-blind, placebo-controlled trial evaluating cysteamine in Huntington's disease.
    Mov Disord 2017 Jun 24;32(6):932-936. Epub 2017 Apr 24.
    Centre Hospitalier Universitaire d'Angers, Département de Biochimie et Génétique et UMR CNRS 6214 - INSERM U1083 et Institut Mitovasc, Angers, France.
    Background: Cysteamine has been demonstrated as potentially effective in numerous animal models of Huntington's disease.

    Methods: Ninety-six patients with early-stage Huntington's disease were randomized to 1200 mg delayed-release cysteamine bitartrate or placebo daily for 18 months. The primary end point was the change from baseline in the UHDRS Total Motor Score. Read More

    How health-related quality of life assessment should be used in advanced colorectal cancer clinical trials.
    Ann Oncol 2017 Apr 18. Epub 2017 Apr 18.
    Institut Hospitalier Franco-Britannique, Levallois-Perret, France.
    Traditionally, the efficacy of cancer treatment in patients with advance or metastatic disease in clinical studies has been studied using overall survival (OS) and more recently tumor-based endpoints such as progression-free survival, measurements of response to treatment. However, these seem not to be the relevant clinical endpoints in current situation if such endpoints were no validated as surrogate of OS to demonstrate the clinical efficacy. Appropriate, meaningful, primary patient-oriented and patient-reported endpoints that adequately measure the effects of new therapeutic interventions are then crucial for the advancement of clinical research in metastatic colorectal cancer to complement the results of tumor-based endpoints. Read More

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