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    Impaired TGF-β signaling in patients with active systemic lupus erythematosus is associated with an overexpression of IL-22.
    Cytokine 2018 Apr 20;108:182-189. Epub 2018 Apr 20.
    Laboratory of Transmission, Control and Immunobiology of Infections, LR11IPT02, Institut Pasteur de Tunis, 1002 Tunis, Tunisia; Faculté de Médecine de Tunis, Université Tunis El Manar, Tunis, Tunisia. Electronic address:
    The mechanisms leading to the disruption of self-tolerance in systemic lupus erythematosus (SLE) remain elusive. Herein, we aimed to decipher the molecular basis of the impaired response of mononuclear cells to TGF-β1. The Smad3-pathway was explored on CD3+ lymphocytes in either active or non active SLE patients. Read More

    Diagnosis-to-Treatment Interval Is an Important Clinical Factor in Newly Diagnosed Diffuse Large B-Cell Lymphoma and Has Implication for Bias in Clinical Trials.
    J Clin Oncol 2018 Apr 19:JCO2017765198. Epub 2018 Apr 19.
    Matthew J. Maurer, Thomas M. Habermann, Carrie A. Thompson, Cristine Allmer, Patrick B. Johnston, Ivana N. Micallef, David J. Inwards, William R. Macon, Andrew L. Feldman, Susan L. Slager, Stephen M. Ansell, James R. Cerhan, Thomas E. Witzig, and Grzegorz S. Nowakowski, Mayo Clinic, Rochester, MN; Hervé Ghesquières and Gilles A. Salles, Université Claude Bernard, Lyon; Jean-Philippe Jais, Richard Delarue, Thierry J. Molina, Hopital Necker, Paris; Corinne Haioun, Groupe Hospitalier Mondor, Créteil; Frederic Peyrade, Centre Antoine Lacassagne, Nice; Olivier Fitoussi, Polyclinique Bordeaux Nord-Aquitaine, Bordeaux; Hervé Tilly, Centre de lutte Contre le Cancer Henri Becquerel, Rouen, France; Brian K. Link, Umar Farooq, Sergei Syrbu, and George J. Weiner, University of Iowa, Iowa City, IA; and Nicolas Ketterer, Clinique Bois-Cerf, Lausanne, Switzerland.
    Purpose Selection bias in clinical trials has consequences for scientific validity and applicability of study results to the general population. There is concern that patients with clinically aggressive disease may not have enrolled in recent diffuse large B-cell lymphoma (DLBCL) trials due to the consent process and the inability to delay therapy for eligibility evaluation. We have examined the diagnosis-to-treatment interval (DTI) and its association with clinical factors and outcome in a clinic-based observational cohort of patients with DLBCL from the United States. Read More

    Efficacy of transcranial direct current stimulation combined with cognitive training in the treatment of apathy in patients with Alzheimer's disease: study protocol for a randomized trial.
    Rev Recent Clin Trials 2018 04 16. Epub 2018 Apr 16.
    Service de geriatrie, CHU hopital Bellier, 44000 Nantes. France.
    Background: Apathy, commonly defined as loss of motivation, is a symptom frequently encountered in Alzheimer's disease (AD). The treatment of apathy remains challenging in the absence of any truly effective medications. Transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) can improve cognitive disorders, but do not appear to improve apathy. Read More

    Effectiveness and safety of anti-TNF therapy for inflammatory bowel disease in liver transplant recipients for primary sclerosing cholangitis: A nationwide case series.
    Dig Liver Dis 2018 Mar 13. Epub 2018 Mar 13.
    University Hospital of St Eloi, Department of Hepatology and Gastroenterology, Montpellier, France.
    Background: There is a lack of consensus regarding the treatment of inflammatory bowel disease (IBD) after liver transplantation (LT) forprimary sclerosing cholangitis (PSC).

    Aim: To investigate the safety and effectiveness of anti-TNF therapy in patients with IBD after a LT for PSC.

    Methods: We reviewed the medical files of all of the IBD patients who underwent a LT for PSC and who were treated with anti-TNF therapy at 23 French liver transplantation centers between 1989 and 2012. Read More

    [Radiation therapy in patients with inflammatory bowel disease. A review].
    Bull Cancer 2018 Apr 10. Epub 2018 Apr 10.
    Université Paris Est Créteil (UPEC), AP-HP, hôpitaux universitaires Henri-Mondor, service d'oncologie-radiothérapie & centre sein Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France; Inserm unité 955 EQ 07, 94010 Créteil, France. Electronic address:
    Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, are multifactorial diseases characterized by a chronic intestinal inflammation. Abdominal and pelvic irradiation can result in acute or chronic digestive toxicity. A few old studies on small population samples have suggested an increase of gastro-intestinal toxicities in patients with IBD in case of irradiation. Read More

    Prognostic value of viral eradication for major adverse cardiovascular events in hepatitis C cirrhotic patients.
    Am Heart J 2018 Apr 7;198:4-17. Epub 2017 Nov 7.
    AP-HP, Hôpital Henri Mondor, Unité de Recherche Clinique (URC-Mondor), and Université Paris-Est, A-TVB DHU, CEpiA (Clinical Epidemiology and Aging) Unit EA4393, UPEC, Créteil.
    Background: The objective was to examine the role of a sustained virological response (SVR) on major adverse cardiovascular events (MACEs) in patients with compensated hepatitis C virus (HCV) cirrhosis.

    Methods: Patients with the following criteria were enrolled in 35 French centers: (1) biopsy-proven HCV cirrhosis; (2) Child-Pugh A; (3) positive viremia; and (4) no prior liver complication, and then prospectively followed. All patients received HCV treatment after inclusion. Read More

    Diagnostic and management of life-threatening Adult-Onset Still Disease: a French nationwide multicenter study and systematic literature review.
    Crit Care 2018 Apr 11;22(1):88. Epub 2018 Apr 11.
    Service de Médecine Interne, PHU3, CHU Hôtel-Dieu, 44093, Nantes, France.
    Background: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disorder. A few patients develop organ complications that can be life-threatening. Our objectives were to describe the disease course and phenotype of life-threatening AOSD, including response to therapy and long-term outcome. Read More

    Case for diagnosis. Atypical genital lesion.
    An Bras Dermatol 2018 Jan-Feb;93(1):143-144
    Service of Sexually Transmitted Infection - Fundação Alfredo da Matta (FUAM) - Manaus (AM), Brazil.
    We present a case of a penile lesion with a clinical appearance similar to Mondor penile disease (thrombosis of the dorsal vein of the penis) or penile sclerosing lymphangitis. Laboratory evaluation, however, showed a solid lesion, with no vascular component to Doppler ultrasonography and no treponema to immunohistochemistry. Histological and serological tests were compatible with secondary syphilis. Read More

    Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity.
    Nat Commun 2018 Apr 10;9(1):1371. Epub 2018 Apr 10.
    Institute of Molecular Virology, Ulm University Medical Center, 89081, Ulm, Germany.
    HIV-1 causes chronic inflammation and AIDS in humans, whereas related simian immunodeficiency viruses (SIVs) replicate efficiently in their natural hosts without causing disease. It is currently unknown to what extent virus-specific properties are responsible for these different clinical outcomes. Here, we incorporate two putative HIV-1 virulence determinants, i. Read More

    Epidermal necrolysis French national diagnosis and care protocol (PNDS; protocole national de diagnostic et de soins).
    Orphanet J Rare Dis 2018 Apr 10;13(1):56. Epub 2018 Apr 10.
    Dermatology Department, AP-HP, Henri Mondor Hospital, 51 avenue du maréchal de Lattre de Tassigny, 94000, Créteil, France.
    Epidermal necrolysis (EN) encompasses Stevens-Johnson syndrome (SJS, < 10% of the skin affected), Lyell syndrome (toxic epidermal necrolysis, TEN, with ≥30% of the skin affected) and an overlap syndrome (10 to 29% of the skin affected). These rare diseases are caused, in 85% of cases, by pharmacological treatments, with symptoms occurring 4 to 28 days after treatment initiation. Mortality is 20 to 25% during the acute phase, and almost all patients display disabling sequelae (mostly ocular impairment and psychological distress). Read More

    Approaches for simplified HCV diagnostic algorithms.
    J Int AIDS Soc 2018 Apr;21 Suppl 2:e25058
    Médecins du Monde France, Paris, France.
    Introduction: In the light of the advances in HCV antiviral therapy, global control of HCV infection becomes feasible but depends on the capacity of countries to identify infected people and to offer them treatment. To achieve the WHO goal which targets a diagnosis rate of 90% by 2030, simplification of screening and diagnosis will be crucial.

    Methods: Published literature, unpublished data and expert consensus were used to determine key parameters, including point-of-care, rapid diagnostic testing, screening, the use of HCV core Ag and dried blood spots; starting from 2008 until November 2017. Read More

    The impact of psoriasis on professional life: PsoPRO, a French national survey.
    J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
    Medicine and Occupational Health, Centre Hospitalier Universitaire (CHU) Angers, Angers, France.
    Background: The physical, social and mental burden of psoriasis is well known but its occupational impact has been less investigated.

    Objective: To assess the impact of psoriasis on the working life of patients compared with the general population.

    Methods: A national survey that compared people with and without psoriasis using online questionnaires. Read More

    Transarterial chemoembolization (TACE) in the management of hepatocellular carcinoma: Results of a French national survey on current practices.
    Diagn Interv Imaging 2018 Mar 30. Epub 2018 Mar 30.
    Department of Radiology, St-Eloi University Hospital-Montpellier, 80, Avenue Augustin Fliche, 34295 Montpellier, France.
    Purpose: To report current practices of transarterial chemoembolization (TACE) by interventional radiologists (IR) for hepatocellular carcinoma (HCC) through a French national survey.

    Materials And Methods: An electronic survey was sent by e-mail to 232 IRs performing TACE in 32 private or public centers. The survey included 66 items including indications for TACE, technical aspects of TACE, other locally available treatments for HCC, follow-up imaging and general aspects of interventional radiology practices. Read More

    Transfusion-related adverse events are decreased in pregnant women with sickle cell disease by a change in policy from systematic transfusion to prophylactic oxygen therapy at home: A retrospective survey by the international sickle cell disease observatory.
    Am J Hematol 2018 Mar 30. Epub 2018 Mar 30.
    Biotherapy Department, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
    Sickle cell disease (SCD) in pregnancy can be associated with adverse maternal and perinatal outcomes. Furthermore, complications of SCD can be aggravated by pregnancy. Optimal prenatal care aims to decrease the occurrence of maternal and fetal complications. Read More

    Tumor Necrosis Factor α and Regulatory T Cells in Oncoimmunology.
    Front Immunol 2018 12;9:444. Epub 2018 Mar 12.
    Université Paris-Est and INSERM U955, Créteil, France.
    Tumor necrosis factor α (TNF) is a potent pro-inflammatory cytokine that has deleterious effect in some autoimmune diseases, which led to the use of anti-TNF drugs in some of these diseases. However, some rare patients treated with these drugs paradoxically develop an aggravation of their disease or new onset autoimmunity, revealing an immunosuppressive facet of TNF. A possible mechanism of this observation is the direct and positive effect of TNF on regulatory T cells (Tregs) through its binding to the TNF receptor type 2 (TNFR2). Read More

    Sex- and age-adjusted prevalence estimates of five chronic inflammatory skin diseases in France: results of the « OBJECTIFS PEAU » study.
    J Eur Acad Dermatol Venereol 2018 Mar 23. Epub 2018 Mar 23.
    Société Française de Dermatologie (SFD), Paris, France.
    Background: There are few population-based studies assessing the prevalence of skin diseases.

    Objectives: To estimate the prevalence of five chronic skin inflammatory diseases, i.e. Read More

    Treatment plans and outcomes in elderly patients reaching advanced chronic kidney disease.
    Nephrol Dial Transplant 2018 Mar 19. Epub 2018 Mar 19.
    Registre REIN, Agence de la Biomedecine, Saint-Denis La Plaine, France.
    Background: Elderly patients with advanced chronic kidney disease require accurate outcome descriptions to make treatment decisions.

    Methods: The PSPA [Parcours de soins des personnes âgées (Treatment pathways for elderly patients)] prospective multicentre cohort study included 573 such patients with a median age of 82 [interquartile range (IQR) 79-86] years and a median estimated glomerular filtration rate of 14 (IQR 11-17) mL/min/1.73 m2 and studied their 5-year outcomes according to the dialysis component of their treatment plans. Read More

    Mycoplasma pneumoniae-related erythema multiforme: clinical and histological features. A single center series of 33 cases compared to 100 cases induced by other causes.
    J Am Acad Dermatol 2018 Mar 17. Epub 2018 Mar 17.
    Dermatology department, AP-HP, Henri Mondor hospital, Créteil; EA 7379 EpiDermE (Epidémiologie en Dermatologie et Evaluation des Thérapeutiques), Université Paris-Est Créteil Val de Marne (UPEC), Creteil; Referral center for toxic bullous diseases, AP-HP, Henri Mondor hospital, Créteil; Université Paris Est-Créteil UPEC, Créteil.
    Background: Mycoplasma pneumoniae (MP) infection has been documented in erythema multiforme (EM) and Stevens-Johnson syndrome-toxic epidermal necrosis (SJS-TEN). Clinical aspects of MP-related EM (MP-EM) have been poorly described in the literature.

    Objective: To highlight differences between MP-EM and non-MP-EM. Read More

    Applicability and accuracy of pretest probability calculations implemented in the NICE clinical guideline for decision making about imaging in patients with chest pain of recent onset.
    Eur Radiol 2018 Mar 19. Epub 2018 Mar 19.
    Department of Radiology, Charité - Universitätsmedizin Berlin Campus Mitte, Humboldt-Universität zu Berlin, Freie Universität Berlin, Charitéplatz 1, 10117, Berlin, Germany.
    Objectives: To analyse the implementation, applicability and accuracy of the pretest probability calculation provided by NICE clinical guideline 95 for decision making about imaging in patients with chest pain of recent onset.

    Methods: The definitions for pretest probability calculation in the original Duke clinical score and the NICE guideline were compared. We also calculated the agreement and disagreement in pretest probability and the resulting imaging and management groups based on individual patient data from the Collaborative Meta-Analysis of Cardiac CT (CoMe-CCT). Read More

    Biological impact of α genes, β haplotypes, and G6PD activity in sickle cell anemia at baseline and with hydroxyurea.
    Blood Adv 2018 Mar;2(6):626-637
    INSERM/Mondor Institute of Biomedical Research 955 Team 2, Laboratory of Excellence GR-Ex, Créteil, France; and.
    Sickle cell anemia (SCA), albeit monogenic, has heterogeneous phenotypic expression, mainly related to the level of hemoglobin F (HbF). No large cohort studies have ever compared biological parameters in patients with major β-globin haplotypes; ie, Senegal (SEN), Benin (BEN), and Bantu/Central African Republic (CAR). The aim of this study was to evaluate the biological impact of α genes, β haplotypes, and glucose-6-phosphate dehydrogenase (G6PD) activity at baseline and with hydroxyurea (HU). Read More

    Cost-effectiveness analysis of elbasvir-grazoprevir regimen for treating hepatitis C virus genotype 1 infection in stage 4-5 chronic kidney disease patients in France.
    PLoS One 2018 15;13(3):e0194329. Epub 2018 Mar 15.
    Ile-De-France URC ECO, Department of Public Health, Henri Mondor Hospital, Créteil, France.
    Objective: To assess the cost-effectiveness of the elbasvir/grazoprevir (EBR/GZR) regimen in patients with genotype 1 chronic hepatitis C virus (HCV) infection with severe and end-stage renal disease compared to no treatment.

    Design: This study uses a health economic model to estimate the cost-effectiveness of treating previously untreated and treatment experienced chronic hepatitis C patients who have severe and end stage renal disease with the elbasvir-grazoprevir regimen versus no treatment in the French context. The lifetime homogeneous markovian model comprises of forty combined health states including hepatitis C virus and chronic kidney disease. Read More

    N-hexane exposure: a cause of small fiber neuropathy.
    J Peripher Nerv Syst 2018 Mar 15. Epub 2018 Mar 15.
    National Referral Center for Neuromuscular Diseases, Institut Hospitalo-Universitaire (IHU) de Neurosciences, University Hospital Pitié Salpêtrière, Paris, France.
    A 59-year-old woman presented with progressive paresthesias of all of her limbs for 4 years, associated with neuropathic pain, tingling in the tongue and allodynia, consistent with small fiber neuropathy (SFN). Several systemic symptoms and signs were found on clinical examination and laboratory work-up. Neurological investigations including neurophysiologic test and skin biopsy supported the diagnosis of SFN. Read More

    Usefulness of echocardiographic-fluoroscopic fusion imaging in adult structural heart disease.
    Arch Cardiovasc Dis 2018 Mar 11. Epub 2018 Mar 11.
    Expert Valve and Structural Center - SOS Endocardites and INSERM U955, Department of Cardiology, Henri-Mondor University Hospital, 94000 Creteil, France.
    Percutaneous approaches to treat structural heart diseases are growing in number and complexity. Multimodality imaging is essential for planning and monitoring such interventions. The combination of three-dimensional transoesophageal echocardiography with fluoroscopy is the cornerstone of interventional imaging. Read More

    Developing collaborative works for faster progress on fungal respiratory infections in cystic fibrosis.
    Med Mycol 2018 Apr;56(suppl_1):42-59
    Host-Pathogen Interaction Study Group (EA 3142), UNIV Angers, UNIV Brest, Université Bretagne-Loire, Angers, France.
    Cystic fibrosis (CF) is the major genetic inherited disease in Caucasian populations. The respiratory tract of CF patients displays a sticky viscous mucus, which allows for the entrapment of airborne bacteria and fungal spores and provides a suitable environment for growth of microorganisms, including numerous yeast and filamentous fungal species. As a consequence, respiratory infections are the major cause of morbidity and mortality in this clinical context. Read More

    Racial disparities in bipolar disorder treatment and research: a call to action.
    Bipolar Disord 2018 Mar 12. Epub 2018 Mar 12.
    Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.
    Objectives: Health disparities between individuals of African and European ancestry are well documented. The disparities in bipolar disorder may be driven by racial bias superimposed on established factors contributing to misdiagnosis, including: evolving empirically based diagnostic criteria (International Classification of Diseases [ICD], Research Diagnostic Criteria [RDC] and Diagnostic and Statistical Manual [DSM]), multiple symptom domains (i.e. Read More

    Solid phase assays versus automated indirect immunofluorescence for detection of antinuclear antibodies.
    Autoimmun Rev 2018 Mar 8. Epub 2018 Mar 8.
    Laboratory Medicine, University Hospitals Leuven, Belgium; Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium. Electronic address:
    Solid phase assays (SPAs) and automated microscope systems are increasingly used to screen for antinuclear antibodies (ANAs). The goal of this study was to evaluate the performance of three automated ANA screening assays; NOVA Lite HEp-2 using NOVA View® (NV, Inova Diagnostics), an automated indirect immunofluorescence method, EliA™ CTD Screen (Fluorescence Enzyme Immunoassay, FEIA; Thermo Fisher) and QUANTA Flash® CTD Screen Plus (Chemiluminescence immunoassay, CIA; Inova Diagnostics). The assays were performed on 480 diagnostic samples from patients with an ANA-associated rheumatic disease (AARD; systemic lupus erythematosus, primary Sjögren's syndrome, systemic sclerosis, inflammatory myopathy, mixed connective tissue disease) and on 767 samples from diseased and healthy controls. Read More

    [Acute aortic syndromes].
    Presse Med 2018 Feb 9;47(2):140-152. Epub 2018 Mar 9.
    SOS Aorte-Est vasculaire, hôpital Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France.
    Acute aortic syndromes include aortic dissections, intramural hematomas, penetrating ulcers, ruptured or contained ruptured aortic aneurysms. In presence of acute thoracic or dorsal pain, elevated D-Dimers and if acute coronary artery syndrome has been ruled out, additional imaging should be performed to detect acute aortic pathologies. Acute type A dissections involve the ascending aorta. Read More

    Vitamin D: part I; from plankton and calcified skeletons (500 million years ago) to rickets.
    Int Orthop 2018 Mar 5. Epub 2018 Mar 5.
    Hôpital Henri Mondor, 94010, Creteil, France.
    The vitamin D history started early in the evolution of life (billion years ago) as a photochemical reaction producing an inert molecule. During the early evolution of vertebrates, this molecule became essential for calcium and bone homeostasis of terrestrial animals and arrived to the status of hormone. Phytoplankton, zooplankton, and most plants and animals that are exposed to sunlight have the capacity to make vitamin D. Read More

    Natural history of portal vein embolization before liver resection: a 23-year analysis of intention-to-treat results.
    Surgery 2018 Mar 2. Epub 2018 Mar 2.
    AP-HP, Hôpital Paul Brousse, Centre Hépato-Biliaire, Villejuif, France; Université Paris-Sud, Villejuif, France; Inserm, Unité 1193, Villejuif, France. Electronic address:
    Background: Portal vein embolization (PVE) use is nowadays debated due to the risk of technical or biological unresectability after the period of time needed to achieve future liver remnant (FLR) hypertrophy. We evaluated the safety and efficacy of PVE in a single high-volume hepatobiliary center, with emphasis in the feasibility to achieve tumor resection.

    Methods: Patients undergoing PVE before major hepatectomy at our institution between 1993 and 2015 were retrospectively analyzed. Read More

    Cortical thickness, stance control, and arithmetic skill: An exploratory study in premanifest Huntington disease.
    Parkinsonism Relat Disord 2018 Feb 23. Epub 2018 Feb 23.
    Genetics of Neurodegenerative and Metabolic Diseases, IRCCS-Foundation Neurological Institute Carlo Besta, Milan, Italy. Electronic address:
    Background: Huntington disease (HD) is an inherited neurodegenerative disorder most commonly manifesting in adulthood. Identification of biomarkers tracking neurodegeneration before the onset of motor symptoms is important for future interventional studies. Our study aimed to contribute in the phenotypic characterization of the premanifest HD phase. Read More

    Muscle ischaemia associated with NXP2 autoantibodies: a severe subtype of juvenile dermatomyositis.
    Rheumatology (Oxford) 2018 May;57(5):873-879
    Reference Center for Neuromuscular Diseases, FILNEMUS, Paris, France.
    Objectives: Myositis-specific autoantibodies (MSAs) are increasingly used to delineate distinct subgroups of JDM. The aim of our study was to explore without a priori hypotheses whether MSAs are associated with distinct clinical-pathological changes and severity in a monocentric JDM cohort.

    Methods: Clinical, biological and histological findings from 23 JDM patients were assessed. Read More

    Central nervous system relapse in patients over 80 years with diffuse large B-cell lymphoma: an analysis of two LYSA studies.
    Cancer Med 2018 Mar 23;7(3):539-548. Epub 2018 Feb 23.
    APHP, Hôpital Saint-Louis, Hemato-Oncologie, Paris, France.
    CNS relapse is reported in 2-5% of diffuse large B-cell lymphoma (DLBCL) patients, dramatically decreasing overall survival (OS). Very few studies address incidence and risk factors of CNS relapse in very elderly patients, a challenging population to treat given their commonly associated comorbidities. A retrospective analysis was performed of 270 DLBCL patients >80 years treated between 2004 and 2013 in two multicentre phase II LYSA trials (LNH03-7B, LNH09-7B) evaluating the addition of rituximab or ofatumumab to mini-CHOP as front-line therapy. Read More

    Somatic IL4R Mutations in Primary Mediastinal Large B-cell lymphoma lead to constitutive JAK-STAT signaling activation.
    Blood 2018 Feb 21. Epub 2018 Feb 21.
    Department of Lymphoid Cancer Research, BC Cancer Agency, Vancouver, Canada;
    Primary mediastinal large B cell lymphoma (PMBCL) is a distinct subtype of diffuse large B cell lymphoma thought to arise from thymic medullary B cells. Gene mutations underlying the molecular pathogenesis of the disease are incompletely characterized. Here, we describe novel somatic mutations in 15 out of 62 primary cases of PMBCL (24. Read More

    Optogenetic Tractography for anatomo-functional characterization of cortico-subcortical neural circuits in non-human primates.
    Sci Rep 2018 Feb 20;8(1):3362. Epub 2018 Feb 20.
    Laboratoire des Maladies Neurodégénératives, UMR9199, CEA, CNRS, Université Paris-Sud, Univ Paris Saclay, MIRCen, I²BM, CEA, Fontenay-aux-Roses, 92265, France.
    Dissecting neural circuitry in non-human primates (NHP) is crucial to identify potential neuromodulation anatomical targets for the treatment of pharmacoresistant neuropsychiatric diseases by electrical neuromodulation. How targets of deep brain stimulation (DBS) and cortical targets of transcranial magnetic stimulation (TMS) compare and might complement one another is an important question. Combining optogenetics and tractography may enable anatomo-functional characterization of large brain cortico-subcortical neural pathways. Read More

    Self-reported history of stroke and long-term living conditions near air pollution sources: results of a national epidemiological study in Lebanon.
    Environ Monit Assess 2018 Feb 20;190(3):153. Epub 2018 Feb 20.
    Department of Neurology, Henri Mondor Hospital AP-HP, Creteil, France.
    Stroke is a disease related to high mortality and morbidity, particularly in developing countries. Some studies have linked self-reported indoor and outdoor pollution to stroke and mini-stroke, while some others showed no association. Our objective was to assess this association in Lebanon, a Middle Eastern developing country. Read More

    Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers.
    Alzheimers Dement 2018 Feb 17. Epub 2018 Feb 17.
    Memory Resource and Research Centre of Montpellier, Department of Neurology, CHU Gui de Chauliac, Université de Montpellier, Montpellier, France.
    Introduction: Diagnostic relevance of plasma amyloid β (Aβ) for Alzheimer's disease (AD) process yields conflicting results. The objective of the study was to assess plasma levels of Aβ and Aβ in amnestic mild cognitive impairment (MCI), nonamnestic MCI, and AD patients and to investigate relationships between peripheral and central biomarkers.

    Methods: One thousand forty participants (417 amnestic MCI, 122 nonamnestic MCI, and 501 AD) from the Biomarker of AmyLoïd pepTide and AlZheimer's diseAse Risk multicenter prospective study with cognition, plasma, cerebrospinal fluid (CSF), and magnetic resonance imaging assessments were included. Read More

    Hypertension prevalence and living conditions related to air pollution: results of a national epidemiological study in Lebanon.
    Environ Sci Pollut Res Int 2018 Feb 13. Epub 2018 Feb 13.
    Department of Neurology, Henri Mondor Hospital AP-HP, Creteil, France.
    Hypertension is a risk factor of several diseases, linked to high mortality and morbidity, particularly in developing countries. Some studies have linked indoor and outdoor pollution exposure items to hypertension, but results were inconsistent. Our objective was to assess the association of living conditions related to air pollution to hypertension in Lebanon, a Middle Eastern country. Read More

    New NO Donor NCX 1443: Therapeutic Effects on Pulmonary Hypertension in the SAD Mouse Model of Sickle Cell Disease.
    J Cardiovasc Pharmacol 2018 Feb 8. Epub 2018 Feb 8.
    Nicox Research Institute Via Ariosto, Milan, Italy.
    Nitric oxide (NO) donors may be useful for treating pulmonary hypertension (PH) complicating sickle cell disease (SCD), as endogenous NO is inactivated by hemoglobin released by intravascular hemolysis. Here, we investigated the effects of the new NO donor NCX1443 on PH in transgenic SAD mice, which exhibit mild SCD without severe hemolytic anemia. In SAD and wild-type (WT) mice, the pulmonary pressure response to acute hypoxia was similar and was abolished by 100 mg/kg NCX1443. Read More

    [Epidemiology of atopic dermatitis].
    Ann Dermatol Venereol 2017 Dec;144 Suppl 5:VS4-VS7
    Department of Dermatology, Henri-Mondor Hospital ; Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
    Atopic dermatitis (AD) is a chronic pruriginous skin disease which usually begins during early life (before the age of 2 years). Recently, the persistence of the disease in adulthood has been clearly established at least in a subset of patients, with frequent moderate to severe forms. The exact prevalence of the disease varies according to the study design and its estimate remains difficult mainly because of the lack of consensual diagnostic tools easily usable in population studies. Read More

    Patterns of Clinical Response to Eculizumab in Patients With C3 Glomerulopathy.
    Am J Kidney Dis 2018 Feb 8. Epub 2018 Feb 8.
    Department of Nephrology and Immunology, Centre Hospitalier Universitaire de Nantes, Nantes, France. Electronic address:
    Background: Cases reports and small series of patients with C3 glomerulopathy have reported variable efficacy of eculizumab.

    Study Design: Case series of C3 glomerulopathy.

    Setting & Participants: Pediatric and adult patients with C3 glomerulopathy treated with eculizumab between 2010 and 2016 were identified through the C3 glomerulopathy French registry database, and a questionnaire was sent to participating French pediatric and adult nephrology centers, as well as one pediatric referral center in Québec, Canada. Read More

    mTOR pathway activation drives lung cell senescence and emphysema.
    JCI Insight 2018 Feb 8;3(3). Epub 2018 Feb 8.
    INSERM U955, Département de Physiologie-Explorations Fonctionnelles, and DHU A-TVB Hôpital Henri Mondor, AP-HP, Créteil, France.
    Chronic obstructive pulmonary disease (COPD) is a highly prevalent and devastating condition for which no curative treatment is available. Exaggerated lung cell senescence may be a major pathogenic factor. Here, we investigated the potential role for mTOR signaling in lung cell senescence and alterations in COPD using lung tissue and derived cultured cells from patients with COPD and from age- and sex-matched control smokers. Read More

    Reply to "Comparison of antipseudomonal betalactams for febrile neutropenia empiric therapy: systematic review and network meta-analysis" by Horita et al.
    Clin Microbiol Infect 2018 Feb 2. Epub 2018 Feb 2.
    Assistance Publique-Hôpitaux de Paris (APHP) - Henri Mondor, Haematology Department and University Paris-Est Créteil, F-94010, Créteil, France.

    2018 update of French Society for Rheumatology (SFR) recommendations about the everyday management of patients with spondyloarthritis.
    Joint Bone Spine 2018 Mar 8. Epub 2018 Mar 8.
    Paris Descartes university, department of rheumatology, hôpital Cochin, AP-HP, EULAR center of excellence, 75014 Paris, France; INSERM (UU1153), clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité, 75014 Paris 14, France.
    Objective: To update French Society for Rheumatology recommendations about the management in clinical practice of patients with spondyloarthritis (SpA). SpA is considered across the range of clinical phenotypes (axial, peripheral, and entheseal) and concomitant manifestations. Psoriatic arthritis is included among the SpA phenotypes. Read More

    The optimal timing of hepatitis C therapy in liver transplant-eligible patients: Cost-effectiveness analysis of new opportunities.
    J Viral Hepat 2018 Feb 6. Epub 2018 Feb 6.
    International Center for Disease Health (ICDH), University of Milan-Bicocca, Monza, Italy.
    Different strategies of DAAs treatment are currently possible both pre- and postliver transplantation (LT). Clinical and economic consequences of these strategies still need to be adequately investigated; this study aims at assessing their cost-effectiveness. A decision analytical model was created to simulate the progression of HCV-infected patients listed for decompensated cirrhosis (DCC) or for hepatocellular carcinoma (HCC). Read More

    Simple, Reproducible, and Efficient Clinical Grading System for Murine Models of Acute Graft-versus-Host Disease.
    Front Immunol 2018 22;9:10. Epub 2018 Jan 22.
    Université Paris-Est, UMR_S955, Université Paris-Est Créteil Val de Marne, Créteil, France.
    Acute graft-versus-host disease (aGVHD) represents a challenging complication after allogeneic hematopoietic stem cell transplantation. Despite the intensive preclinical research in the field of prevention and treatment of aGVHD, and the presence of a well-established clinical grading system to evaluate human aGVHD, such a valid tool is still lacking for the evaluation of murine aGVHD. Indeed, several scoring systems have been reported, but none of them has been properly evaluated and they all share some limitations: they incompletely reflect the disease, rely on severity stages that are distinguished by subjective assessment of clinical criteria and are not easy to discriminate, which could render evaluation more time consuming, and their reproducibility among different experimenters is uncertain. Read More

    Refractory relapsing polychondritis: challenges and solutions.
    Open Access Rheumatol 2018 9;10:1-11. Epub 2018 Jan 9.
    Department of Rheumatology, Henri Mondor Hospital, University Paris 12, Créteil, France.
    Relapsing polychondritis is a severe systemic immune-mediated disease characterized by an episodic and progressive inflammatory condition with progressive destruction of cartilaginous structures. This disease has for nearly a century kept secrets not yet explained. The real incidence and prevalence of this rare disease are unknown. Read More

    Adolescence/adult onset MTHFR deficiency may manifest as isolated and treatable distinct neuro-psychiatric syndromes.
    Orphanet J Rare Dis 2018 Feb 1;13(1):29. Epub 2018 Feb 1.
    Neurology Department, Reference Center for Lysosomal Diseases, Neurogenetics and Metabolism Unit, AP-HP, GH Pitié-Salpêtrière-Charles Foix, Paris, France.
    5,10-Methylene-tetrahydrofolate reductase (MTHFR) deficiency is a genetic disorder that can occur at any age and can be easily detected by increased homocysteinemia. In adolescence/adult onset forms, the clinical picture is often complex with association of various neurological features and thrombosis.Here we report the cases of two adult siblings who experienced focal epilepsy at 18 years old as a first disease manifestation, without other symptom during several years. Read More

    Penile Mondor's disease in a patient treated with radical chemoradiation for anal cancer.
    Oxf Med Case Reports 2017 Aug 2;2017(8):omx036. Epub 2017 Aug 2.
    Department of Radiation Oncology, Bank of Cyprus Oncology Center 2006, Strovolos 2012, Nicosia, Cyprus.
    Penile Mondor's disease is a rare condition characterized by sclerosing thrombophlebitis of the superficial dorsal penile vein. Usually its causes are benign, but it is also evident in cancer patients. We report the case of a 62-year-old man with a cT4 anal cancer (infiltration of corpora spongiosa and penile bulb), associated with extensive loco-regional lymphadenopathy, who developed painful lumps in the midline of the anterior penile surface while receiving radical chemoradiotherapy. Read More

    Extranodal natural killer/T-cell lymphoma, nasal type, in Senegal.
    Int J Dermatol 2018 Apr 30;57(4):401-405. Epub 2018 Jan 30.
    Department of Dermatology, Aristide LeDantec University Hospital, Dakar, Senegal.
    Introduction: The distribution of extranodal NK/T-cell lymphoma (ENKTCL) is highly inhomogeneous throughout the world. In Sub-Saharan Africa, despite the precocity of Epstein-Barr virus (EBV) infection and its endemicity, ENKTCL remains exceptionally reported. The purpose of this study was to report the epidemiological, clinical, paraclinical, and evolutionary characteristics of ENKTCL at the Aristide LeDantec University Hospital in Dakar, Senegal. Read More

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