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    Unravelling the pharmacologic opportunities and future directions for targeted therapies in gastro-intestinal cancers Part 1: GI carcinomas.
    Pharmacol Ther 2017 Feb 13. Epub 2017 Feb 13.
    Department of Medical Oncology, Henri Mondor University Hospital, AP-HP, Paris Est Créteil University (UPEC), 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France.
    Until the 1990s, cytotoxic chemotherapy has been the cornerstone of medical therapy for gastrointestinal (GI) cancers. Better understanding of the molecular biology of cancer cell has led to the therapeutic revolution of targeted therapies, i.e. Read More

    Isolated Pericardial Infiltration Without Myocardial Involvement in Light-Chain-Related Amyloidosis.
    Ann Thorac Surg 2017 Mar;103(3):e255-e257
    University Paris-Est Créteil, Créteil, France; Mondor Amyloidosis Network, Créteil, France; Department of Cardiology, Henri-Mondor Teaching Hospital, Créteil, France; GRC Amyloid Research Institute, Créteil, France. Electronic address:
    Light-chain-related amyloidosis is a systemic disease characterized by continuous accumulation of insoluble fibrillar proteins in different organs. Cardiac involvement is frequent in this condition. However, atypical presentations and unusual amyloid deposits localization may be encountered making the diagnosis challenging. Read More

    Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci.
    Nat Genet 2017 Feb 20. Epub 2017 Feb 20.
    Division of Hematology/Oncology, Boston Children's Hospital; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Harvard Stem Cell Institute; and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
    Cas9-mediated, high-throughput, saturating in situ mutagenesis permits fine-mapping of function across genomic segments. Disease- and trait-associated variants identified in genome-wide association studies largely cluster at regulatory loci. Here we demonstrate the use of multiple designer nucleases and variant-aware library design to interrogate trait-associated regulatory DNA at high resolution. Read More

    Early non-response to certolizumab pegol in rheumatoid arthritis predicts treatment failure at one year. Data from a randomised Phase III clinical trial.
    Joint Bone Spine 2017 Feb 15. Epub 2017 Feb 15.
    Paris 6 University-GRC UPMC-08; AP-HP, Rheumatology Department, 75005 Paris, and Groupe Hospitalier Pitié Salpêtrière, 75013 Paris, France.
    Objectives: To compare different early clinical criteria of non-response determined at three months as predictors of clinical failure at one year in patients with rheumatoid arthritis starting therapy with certolizumab pegol.

    Methods: Data were derived from a randomised Phase III clinical trial in patients with rheumatoid arthritis who failed to respond to methotrexate monotherapy. Patients included in this post-hoc analysis were treated with certolizumab pegol (400mg qd reduced to 200mg qd after one month) and with methotrexate. Read More

    The New Aptima HBV Quant Real-time TMA Assay Accurately Quantifies Hepatitis B Virus DNA from Genotypes A to F.
    J Clin Microbiol 2017 Feb 15. Epub 2017 Feb 15.
    National Reference Center for Viral Hepatitis B, C and Delta, Department of Virology, Hôpital Henri Mondor, Université Paris-Est, Créteil, France.
    Sensitive and accurate hepatitis B virus (HBV) DNA detection and quantification are essential to diagnose HBV infection, establish the prognosis of HBV-related liver disease, guide the decision to treat and monitor the virological response to antiviral treatment and the emergence of resistance. Currently available HBV DNA platforms and assays are generally designed for batching multiple specimens within an individual run and require at least one full day of work to complete the analyses. The aim of this study was to evaluate the ability of the newly developed, fully automated, one-step Aptima HBV Quant assay to accurately detect and quantify HBV DNA in a large series of patients infected with different HBV genotypes. Read More

    Superiority in Rhesus Macaques of Targeting HIV-1 Env Gp140 to CD40 Versus LOX-1 in Combination with Replication Competent NYVAC-KC for Induction of Env-Specific Antibody and T Cell Responses.
    J Virol 2017 Feb 15. Epub 2017 Feb 15.
    Vaccine Research Institute, Université Paris-Est, Faculté de Médecine, INSERM U955, and Assistance Publique-Hôpitaux de Paris, Groupe Henri-Mondor Albert- Chenevier, service d'immunologie clinique, Créteil, France
    We compared the HIV-1-specific immune responses generated by targeting HIV-1 envelope protein (Env gp140) to either CD40 or LOX-1, two endocytic receptors on dendritic cells (DCs), in Rhesus macaques primed with a poxvirus vector (NYVAC-KC) expressing Env gp140. The DC-targeting vaccines, humanized recombinant monoclonal antibodies fused to Env gp140, were administered as a boost with poly ICLC adjuvant either alone or co-administered with the NYVAC-KC vector. All the DC-targeting vaccine administrations with poly ICLC increased the low-level serum anti-Env IgG responses elicited by NYVAC-KC priming significantly more (up to P =0. Read More

    Pathologic Outcomes of Laparoscopic vs Open Mesorectal Excision for Rectal Cancer: A Systematic Review and Meta-analysis.
    JAMA Surg 2017 Feb 8:e165665. Epub 2017 Feb 8.
    Department of Digestive, Hepatobiliary Surgery and Liver Transplantation, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Est-Créteil, Créteil, France.
    Importance: Rectal resection with mesorectal excision is the mainstay treatment for rectal cancer.

    Objective: To review and analyze the evidence concerning the pathologic outcomes of laparoscopic (LRR) vs open (ORR) rectal resection for rectal cancer.

    Data Sources: The Cochrane Central Register of Controlled Trials, MEDLINE (through PubMed), EMBASE, Scopus databases, and clinicaltrials. Read More

    Impact of Pulmonary Hypertension on Outcome in Patients with Severe Aortic Stenosis and Preserved Left Ventricular Ejection Fraction.
    Clin Res Cardiol 2017 Feb 14. Epub 2017 Feb 14.
    Service Cardiologie, CHU Limoges, Hôpital Dupuytren, Limoges, 87042, France.
    Aims: The prognostic impact of elevated pulmonary arterial pressure (PAP) remains controversial in aortic stenosis (AS) and few studies focused on patients with preserved left ventricular ejection fraction (LVEF). We aimed to investigate the impact of pulmonary hypertension (PH), invasively derived, on survival in severe AS with preserved LVEF.

    Methods And Results: Between 2000 and 2010, 749 patients (74 ± 8 years, 57% males) with preserved LVEF and severe AS without other valvular heart disease underwent cardiac catheterization. Read More

    Safety and Efficacy of Elbasvir/Grazoprevir in Patients with Hepatitis C Virus Infection and Compensated Cirrhosis: an Integrated Analysis.
    Gastroenterology 2017 Feb 10. Epub 2017 Feb 10.
    Merck & Co., Inc., Kenilworth, New Jersey.
    Background & Aims: Persons with hepatitis C virus (HCV) infection are at risk of progressive liver disease, cirrhosis, and decompensation. We analyzed the effects of the direct-acting antiviral agents elbasvir and grazoprevir in patients with HCV infection and compensated cirrhosis, combining data from 6 clinical trials.

    Methods: We performed an integrated analysis of 402 patients with HCV genotype 1, 4, or 6 infection and Child-Pugh A compensated cirrhosis enrolled in 6 clinical trials. Read More

    Risk of autoimmune diseases and human papilloma virus (HPV) vaccines: Six years of case-referent surveillance.
    J Autoimmun 2017 Feb 9. Epub 2017 Feb 9.
    LASER Europe Ltd, London, 66 Chiltern St, London W1U 4JT, United Kingdom; Department of Epidemiology, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK.
    Background: Safety of HPV vaccines is still in question due to reports of autoimmune diseases (ADs) following HPV immunization.

    Objectives: To assess the risk of ADs associated with HPV vaccination of female adolescents/young adults in France.

    Methods: Systematic prospective case-referent study conducted to assess the risks associated with real-life use of HPV vaccines. Read More

    Daclatasvir Plus Sofosbuvir, With or Without Ribavirin, for Hepatitis C Virus Genotype 3 in a French Early Access Programme.
    Liver Int 2017 Feb 8. Epub 2017 Feb 8.
    INSERM U954, CHU de Nancy and Université de Lorraine, Vandoeuvre-lès-Nancy, France.
    Background And Aims: Optimally effective treatment for hepatitis C virus (HCV) genotype 3 (GT3) is urgently needed, particularly in advanced liver disease. Daclatasvir (DCV) plus sofosbuvir (SOF) was efficacious in phase 3 studies. Real-world data for DCV+SOF in advanced GT3 infection are presented from the French Temporary Authorisation for Use programme, which allowed patients in need without other treatment options access to DCV ahead of its market authorization. Read More

    Early detection and curative treatment of hepatocellular carcinoma: A cost-effectiveness analysis in France and in the United States.
    Hepatology 2017 Feb 8. Epub 2017 Feb 8.
    AP-HP, Health economics research unit, Paris, France.
    Hepatocellular carcinoma (HCC) is the leading cause of death in patients with cirrhosis. Patients outside clinical trials seldom benefit from evidence-based monitoring. The objective of this study was to estimate the cost-effectiveness of complying with HCC screening guidelines. Read More

    Quality of Life in Patients with Genetic Neuromuscular Disease Questionnaire: Rasch validation of the French Version (QoL-gNMD).
    Muscle Nerve 2017 Feb 6. Epub 2017 Feb 6.
    EA 3797, Université de Reims Champagne-Ardenne, Reims, France.
    Introduction: Slowly-progressive, genetic neuromuscular diseases (gNMDs) often lead to important motor deficiencies and functional limitations. The QoL-gNMD is a new health-related quality of life questionnaire developed for these patients. The purpose of the present study was to validate the French version of the QoL-gNMD and to calibrate its measurement system. Read More

    Repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer's disease.
    Neurophysiol Clin 2017 Feb 1. Epub 2017 Feb 1.
    EA4391, Clinical Neurophysiology Department, Henri Mondor University Hospital, University Paris-Est Créteil, 94010 Créteil cedex, France.
    Objective: To assess the efficacy of a combination of cognitive training (COG) and repetitive transcranial magnetic stimulation (rTMS), on cognitive performance, locomotor activity, apathy, caregiver burden and dependence of patients with Alzheimer's disease (AD).

    Methods: A combination of COG and rTMS was performed in 10 patients with AD (NeuroAD procedure) for a period of 5weeks (one session per day, 5days a week), without maintenance sessions. Patients were evaluated at the end of the treatment (D45) and 6months later (M6) by the Mini Mental State Examination (MMSE), the Alzheimer disease assessment scale - cognitive subscale (ADAS-Cog), various neuropsychological tests and clinical scores specific for locomotor activity, apathy, caregiver burden, and dependence, recorded before the study (baseline). Read More

    The Hypothesis of the Human iNKT/Innate CD8(+) T-Cell Axis Applied to Cancer: Evidence for a Deficiency in Chronic Myeloid Leukemia.
    Front Immunol 2016 16;7:688. Epub 2017 Jan 16.
    INSERM 1082, Poitiers, France; Service d'Immunologie et Inflammation, Poitiers, France; CHU de Poitiers, Poitiers, France; Université de Poitiers, Poitiers, France.
    We recently identified a new human subset of NK-like [KIR/NKG2A(+)] CD8(+) T cells with a marked/memory phenotype, high Eomesodermin expression, potent antigen-independent cytotoxic activity, and the capacity to generate IFN-γ rapidly after exposure to pro-inflammatory cytokines. These features support the hypothesis that this new member of the innate T cell family in humans, hereafter referred to as innate CD8(+) T cells, has a role in cancer immune surveillance analogous to invariant natural killer T (iNKT) cells. Here, we report the first quantitative and functional analysis of innate CD8(+) T cells in a physiopathological context in humans, namely chronic myeloid leukemia (CML), a well-characterized myeloproliferative disorder. Read More

    Recent advances in biochemical and molecular diagnostics for the rapid detection of antibiotic-resistant Enterobacteriaceae: a focus on ß-lactam resistance.
    Expert Rev Mol Diagn 2017 Jan 30. Epub 2017 Jan 30.
    c Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine , University of Fribourg , Fribourg , Switzerland.
    Introduction: Drug resistance among bacteria is a scourge to patients and infectious disease and infection control specialists. The rapid detection of resistance is a challenge for clinical microbiologists who wish to prevent deleterious individual and collective consequences such as (i) delaying efficient antibiotic therapy, which worsens the survival rate of the most severely ill patients, or (ii) delaying the isolation of the carriers of multidrug-resistant bacteria and promoting outbreaks; this last consequence is of special concern, and there are an increasing number of approaches and market-based solutions in response. Areas covered: β-lactams are the cornerstone of numerous empirical and definitive antimicrobial strategies. Read More

    Simeprevir and daclatasvir for 12 or 24 weeks in treatment-naïve patients with HCV genotype 1b and advanced liver disease.
    Liver Int 2017 Jan 30. Epub 2017 Jan 30.
    Department of Gastroenterology and Hepatology, J.W. Goethe University, Frankfurt, Germany.
    Background & Aims: We investigated the efficacy and safety of simeprevir (SMV) plus daclatasvir (DCV) in treatment-naïve patients with chronic, genotype (GT) 1b hepatitis C virus (HCV) infection and advanced liver disease, excluding patients with pre-defined NS5A resistance-associated substitutions (RAS) METHODS: This phase II, open-label, single-arm, multicentre study included patients aged ≥18 years with advanced fibrosis or compensated cirrhosis (METAVIR F3/4). Patients with NS5A-Y93H or L31M/V RAS at screening were excluded. SMV (150 mg) + DCV (60 mg) once daily was administered for 12 or 24 weeks; treatment could be extended to 24 weeks prior to or at the Week 12 visit. Read More

    miR-125b and miR-532-3p predict efficiency of the rituximab-mediated lymphodepletion in chronic lymphocytic leukemia patients. A FILO study.
    Haematologica 2017 Jan 25. Epub 2017 Jan 25.
    INSERM, U1183, Inst. Regenerative Medicine and Biotherapy, University hospital Montpellier, France.
    The underlying in vivo mechanisms of rituximab action remain incompletely understood in chronic lymphocytic leukemia. Recent data suggest that circulating miRNAs correlate with chronic lymphocytic leukemia progression and response to rituximab. Our study aimed at identifying circulating miRNAs that predict response to rituximab monotherapy in chronic lymphocytic leukemia patients. Read More

    Impact of intraoperative blood transfusion on short and long term outcomes after curative hepatectomy for intrahepatic cholangiocarcinoma: a propensity score matching analysis by the AFC-IHCC study group.
    HPB (Oxford) 2017 Jan 22. Epub 2017 Jan 22.
    Department of Hepatobiliary Surgery and Liver Transplantation, AP-HP Hôpital Henri Mondor, Créteil, France; INSERM, U955, Créteil, France. Electronic address:
    Background: The impact of IBT on outcomes following IHCC resection remains to be ascertained.

    Methods: All consecutive IHCC resected were analyzed. A first cohort (n = 569) was used for investigating short-term outcomes (morbidity and mortality). Read More

    Kidney transplantation in patients with systemic sclerosis: a nationwide multicenter study.
    Transpl Int 2017 Jan 25. Epub 2017 Jan 25.
    Centre Hospitalier Universitaire de Rouen, Nephrology Dialysis Transplantation, Rouen, Haute-Normandie, FR.
    Kidney transplantation is one of the therapeutic options for end-stage renal disease (ESRD) in systemic sclerosis (SS). Current evidence demonstrates poorer patient and graft survival after transplantation in SS than in other primary kidney diseases. All the patients presenting ESRD associated with SS who had received a kidney allograft between 1987 and 2013 were systematically included from 20 French kidney transplantation centres. Read More

    Spontaneous healing of lateral femoral cutaneous nerve injury and improved quality of life after total hip arthroplasty via a direct anterior approach.
    J Orthop Surg (Hong Kong) 2017 Jan;25(1):2309499016684750
    1 Department of Orthopaedic Surgery, Juntendo University, Bunkyo-ku, Tokyo, Japan.
    Purpose: How the symptomatology of lateral femoral cutaneous nerve (LFCN) injury changes after total hip arthroplasty (THA) via direct anterior approach (DAA) is not known. Our hypothesis was that the symptoms of LFCN injury after THA via DAA in longer follow-up periods would resolve spontaneously, leading to an improved quality of life (QOL). The aims of this study were to investigate how the symptom LFCN injury changed after DAA-THA, and how those changes affected QOL. Read More

    Genetics of schizophrenia: A consensus paper of the WFSBP Task Force on Genetics.
    World J Biol Psychiatry 2017 Jan 23:1-14. Epub 2017 Jan 23.
    a Department of Psychiatry, Psychotherapy, and Psychosomatics , Martin Luther University of Halle-Wittenberg , Halle , Germany.
    Objectives: Schizophrenia is a severe psychiatric disease affecting about 1% of the general population. The relative contribution of genetic factors has been estimated to be up to 80%. The mode of inheritance is complex, non-Mendelian, and in most cases involving the combined action of large numbers of genes. Read More

    Long-Term Follow-Up of the French Stop Imatinib (STIM1) Study in Patients With Chronic Myeloid Leukemia.
    J Clin Oncol 2017 Jan 31;35(3):298-305. Epub 2016 Oct 31.
    Gabriel Etienne and François-Xavier Mahon, Institut Bergonié, Bordeaux; Joëlle Guilhot and François Guilhot, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire (CHU) de Poitiers, Poitiers; Delphine Rea, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP); Bruno Varet, Hôpital Necker, AP-HP et Université Paris Descartes, Paris; Françoise Rigal-Huguet, Institut Universitaire du Cancer Toulouse-Oncopole, Toulouse; Franck Nicolini, Centre Hospitalier Lyon Sud, Pierre Bénite; Aude Charbonnier, Institut Paoli Calmette, Marseille; Agnès Guerci-Bresler, CHU Brabois Vandoeuvre, Nancy; Laurence Legros, Hôpital de l'Archet, Centre Hospitalier Universitaire de Nice, Nice; Martine Gardembas, CHU d'Angers, Angers; Viviane Dubruille, CHU Hôtel-Dieu, Nantes; Michel Tulliez, Hôpital Henri Mondor, Créteil; Marie-Pierre Noel, Hôpital Claude Huriez, Centre Hospitalier Regional Universitaire de Lille, Lille; Jean-Christophe Ianotto, CHU Morvan, Brest; Bruno Villemagne, Centre Hospitalier Départemental La Roche-Sur-Yon, La Roche-Sur-Yon; Martin Carré, Hôpital Albert Michallon, CHU de Grenoble, Grenoble; Philippe Rousselot, Hôpital André Mignot, Le Chesnay; and François-Xavier Mahon, CHU de Bordeaux, INSERM U1218, Bordeaux, France.
    Purpose Imatinib (IM) can safely be discontinued in patients with chronic myeloid leukemia (CML) who have had undetectable minimal residual disease (UMRD) for at least 2 years. We report the final results of the Stop Imatinib (STIM1) study with a long follow-up. Patients and Methods IM was prospectively discontinued in 100 patients with CML with UMRD sustained for at least 2 years. Read More

    New guidelines, new recommendations! But what is really new? A pragmatic interpretation of the 2016 European guidelines for the management of chronic heart failure.
    Arch Cardiovasc Dis 2017 Jan 9;110(1):1-6. Epub 2017 Jan 9.
    Service de cardiologie, GRC Amyloid Research Institute and Mondor Amyloidosis Network, DHU A-TVB, UPEC, hôpital Henri-Mondor, université Paris Est Créteil, Assistance publique-Hôpitaux de Paris, 94010 Paris, France.

    The Effectiveness of Diclofenac Sodium in the Treatment of Mondor's Disease of the Breast: The Topical Patch Compared to the Oral Capsules.
    Breast J 2017 Jan 12. Epub 2017 Jan 12.
    Department of Pharmacy, Al Ansar General Hospital, Medina, Saudi Arabia.
    Mondor's disease of the breast is a rare, benign sclerosing superficial thrombophlebitis of the subcutaneous veins of the anterior or lateral chest wall, which is treated conservatively. We aim in this study to evaluate the outcome and effectiveness of our treatment protocol using oral diclofenac sodium and topical diclofenac sodium patch in 172 patients. A retrospective database analysis of 172 female patients between January 2001 and December 2010 was done. Read More

    Prognostic value of the new Grade Groups in Prostate Cancer: a multi-institutional European validation study.
    Prostate Cancer Prostatic Dis 2017 Jan 10. Epub 2017 Jan 10.
    Comprehensive Cancer Center, Department of Urology, General Hospital, Medical University Vienna, Vienna, Austria.
    Background: We aimed to assess the prognostic relevance of the new Grade Groups in Prostate Cancer (PCa) within a large cohort of European men treated with radical prostatectomy (RP).

    Methods: Data from 27 122 patients treated with RP at seven European centers were analyzed. We investigated the prognostic performance of the new Grade Groups (based on Gleason score 3+3, 3+4, 4+3, 8 and 9-10) on biopsy and RP specimen, adjusted for established clinical and pathological characteristics. Read More

    The clinicopathologic characteristics of kidney diseases related to monotypic IgA deposits.
    Kidney Int 2017 Mar 6;91(3):720-728. Epub 2017 Jan 6.
    Department of Nephrology, CHU Poitiers, Centre de référence maladies rares amylose AL et autres maladies par dépôts d'immunoglobulines monoclonales, Poitiers, France; Department of Immunology, National Center for Scientific Research, Joint Research Unit 7276, University of Limoges, Centre de référence maladies rares amylose AL et autres maladies par dépôts d'immunoglobulines monoclonales, Limoges, France.
    Monoclonal gammopathy of renal significance (MGRS) regroups renal disorders caused by a monoclonal immunoglobulin without overt hematological malignancy. MGRS includes tubular disorders, glomerular disorders with organized deposits, and glomerular disorders with non-organized deposits, such as proliferative glomerulonephritis with monoclonal IgG deposits. Since glomerular involvement related to monotypic IgA deposits is poorly described we performed retrospective analysis and defined clinico-biological characteristics, renal pathology, and outcome in 19 referred patients. Read More

    Autoimmune cytopenias associated with inflammatory bowel diseases: Insights from a multicenter retrospective cohort.
    Dig Liver Dis 2016 Dec 23. Epub 2016 Dec 23.
    Department of Gastroenterology, Henri Mondor Hospital, AP-HP, EC2M3-Equipe Universitaire, Paris Est-Créteil (UPEC) Val de Marne University, Creteil, France.
    Introduction: Autoimmune cytopenias (AIC) including autoimmune hemolytic anemia (AIHA) and immunologic thrombocytopenia (ITP) are rare immunologic disorders, scarcely reported in inflammatory bowel diseases (IBD). We conducted a multicentric retrospective study, including a case-control analysis, that aimed to describe the characteristics and outcomes of patients affected by AIC and IBD.

    Method: Forty cases were recruited from 4 IBD centers and 2 AIC tertiary centers. Read More

    Complications after Hepatectomy for Hepatocellular Carcinoma Independently Shorten Survival: A Western, Single-Center Audit.
    Ann Surg Oncol 2017 Jan 5. Epub 2017 Jan 5.
    Department of Hepatopancreatobiliary Surgery and Liver Transplantation, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, AP-HP, Créteil, France.
    Background: The impact of postoperative complications (POCs) on long-term outcomes following hepatocellular carcinoma (HCC) resection remains to be ascertained.

    Methods: All consecutive HCC resected at a single center were analyzed. Patients with POCs, classified according to Clavien classification, were compared to those without in terms of demographics, pathology, management, overall survival (OS), and disease-free survival (DFS). Read More

    Clinical Characteristics and Prognostic Factors of Plasmablastic Lymphoma Patients: Analysis of 135 Patients from the Lysa Group.
    Ann Oncol 2016 Dec 28. Epub 2016 Dec 28.
    Department of Hematology, University Hospital of Montpellier, Montpellier, France
    Background: Plasmablastic lymphoma (PBL), initially described in 1997 in the oral cavity of HIV positive patients, is now recognized as a distinct aggressive and rare entity of diffuse large B-cells lymphoma (DLBCL) by the WHO (World Health Organization) classification. Since the original description, others cases have been reported. However, these are largely derived from case reports or small series limiting any definitive conclusions on clinical characteristics and outcome. Read More

    Pioglitazone together with imatinib in chronic myeloid leukemia: A proof of concept study.
    Cancer 2016 Dec 27. Epub 2016 Dec 27.
    CEA, Institute of Emerging Diseases and Innovative Therapies, University Paris-Sud UMR 007, Fontenay-aux-Roses, France.
    Background: We recently reported that peroxisome proliferator-activated receptor γ agonists target chronic myeloid leukemia (CML) quiescent stem cells in vitro by decreasing transcription of STAT5. Here in the ACTIM phase 2 clinical trial, we asked whether pioglitazone add-on therapy to imatinib would impact CML residual disease, as assessed by BCR-ABL1 transcript quantification.

    Methods: CML patients were eligible if treated with imatinib for at least 2 years at a stable daily dose, having yielded major molecular response (MMR) but not having achieved molecular response 4. Read More

    Protective coding variants in CFH and PELI3 and a variant near CTRB1 are associated with age-related macular degeneration†.
    Hum Mol Genet 2016 Dec 22. Epub 2016 Dec 22.
    Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Boston, MA, USA
    Although numerous common age-related macular degeneration (AMD) alleles have been discovered using genome-wide association studies, substantial disease heritability remains unexplained. We sought to identify additional common and rare variants associated with advanced AMD. A total of 4,332 cases and 25,268 controls of European ancestry from three different populations were genotyped using the Illumina Infinium HumanExome BeadChip. Read More

    Interleukin-15 is associated with severity and mortality in Stevens-Johnson syndrome/toxic epidermal necrolysis.
    J Invest Dermatol 2016 Dec 20. Epub 2016 Dec 20.
    Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan; Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linkou Keelung, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan. Electronic address:
    Early diagnosis and prognosis monitoring for Stevens-Johnson syndrome (SJS)/ toxic epidermal necrolysis (TEN) still remain a challenge. This study aims to explore any cytokine/chemokine with prognostic potential in SJS/TEN. Through screening a panel of 28 serological factors, IL-6, IL-8, IL-15, TNF-α, and granulysin were upregulated in SJS/TEN patients and selected for the further validation in total 155 SJS/TEN patients, including 77 from Taiwan and 78 from RegiSCAR (the Registry of Severe Cutaneous Adverse Reactions). Read More

    [Oral care recommendations for patients with oral autoimmune bullous diseases].
    Ann Dermatol Venereol 2016 Dec 20. Epub 2016 Dec 20.
    Service de dermatologie, hôpital de Dunkerque, 130, avenue Louis-Herbeaux, 59240 Dunkerque, France.
    Background: Autoimmune bullous diseases (AIBD) may cause chronic oral lesions that progress insidiously.

    Aims: To provide recommendations for optimal oral-dental management of patients presenting AIBD with oral involvement.

    Patients And Methods: In the absence of scientific studies with high levels of proof, these recommendations have been drawn up at two meetings by a committee of experts on AIBD comprising 7 dermatologists, 1 stomatologist, 1 maxillofacial surgeon, 2 odontologists and 4 parodontologists. Read More

    Early Coronary Reperfusion Facilitates Return of Spontaneous Circulation and Improves Cardiovascular Outcomes After Ischemic Cardiac Arrest and Extracorporeal Resuscitation in Pigs.
    J Am Heart Assoc 2016 Dec 22;5(12). Epub 2016 Dec 22.
    Inserm, U955, Equipe 03, Créteil, France
    Background: Extracorporeal cardiopulmonary resuscitation (ECPR) is widely proposed for the treatment of refractory cardiac arrest. It should be associated with coronary angiography if coronary artery disease is suspected. However, the prioritization of care remains unclear in this situation. Read More

    Age- and time-dependent prevalence and incidence of hepatitis C virus infection in drug users in France, 2004-2011: model-based estimation from two national cross-sectional serosurveys.
    Epidemiol Infect 2016 Dec 22:1-13. Epub 2016 Dec 22.
    Santé publique France,French National Public Health Agency,Saint-Maurice,France.
    Hepatitis C virus (HCV) infection is a public health issue worldwide. Injecting drug use remains the major mode of transmission in developed countries. Monitoring the HCV transmission dynamic over time is crucial, especially to assess the effect of harm reduction measures in drug users (DU). Read More

    Idiopathic linear IgA bullous dermatosis: prognostic factors based on a case-series of 72 adults.
    Br J Dermatol 2016 Dec 20. Epub 2016 Dec 20.
    Referral Center for Autoimmune Blistering Diseases, Île-de-France, France.
    Background: Linear IgA bullous dermatosis (LABD) is a clinically and immunologically heterogeneous, subepidermal, autoimmune blistering disease (AIBD), whose long-term evolution is poorly described.

    Objectives: To investigate the clinical and immunological characteristics, follow-up and prognostic factors of adult idiopathic LABD.

    Methods: This retrospective study, conducted in our AIBD Referral Center, included adults, diagnosed between 1995 and 2012, with idiopathic LABD, defined as pure or predominant IgA deposits by direct immunofluorescence. Read More

    Leg ulcers in sickle-cell disease: factors predictive of healing A multicenter, prospective, cohort study.
    Br J Dermatol 2016 Dec 19. Epub 2016 Dec 19.
    Unité des Maladies Génétiques du Globule Rouge, Service de Médecine Interne, Centre de Référence de la Drépanocytose, Hôpital Henri-Mondor, APHP, and Université Paris-Est Créteil, Créteil, France.
    Background: Leg ulcers (LUs) are a chronic and severe complication of sickle-cell disease (SCD). A prospective study identifying SCD patients' factors associated with LU complete healing and recurrence is lacking.

    Objectives: To determine clinical and biological factors associated with SCD-LU complete healing and recurrence. Read More

    Improved decision making in intermediate-risk prostate cancer: a multicenter study on pathologic and oncologic outcomes after radical prostatectomy.
    World J Urol 2016 Dec 16. Epub 2016 Dec 16.
    Department of Urology, Institut Mutualiste Monsouris, Paris-Descartes University, Paris, France.
    Background: Prognoses for intermediate-risk prostate cancer (PCa) remain heterogeneous. Improved substratification could optimize treatment and monitoring strategies. The objective was to validate this subclassification in a radical prostatectomy (RP) series. Read More

    The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development.
    Proc Natl Acad Sci U S A 2016 Dec 12;113(52):15084-15089. Epub 2016 Dec 12.
    The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada;
    Oncogenic isocitrate dehydrogenase (IDH)1 and IDH2 mutations at three hotspot arginine residues cause an enzymatic gain of function that leads to the production and accumulation of the metabolite 2-hydroxyglutarate (2HG), which contributes to the development of a number of malignancies. In the hematopoietic system, mutations in IDH1 at arginine (R) 132 and in IDH2 at R140 and R172 are commonly observed in acute myeloid leukemia, and elevated 2HG is observed in cells and serum. However, in angioimmunoblastic T-cell lymphoma (AITL), mutations are almost exclusively restricted to IDH2 R172, and levels of 2HG have not been comprehensively measured. Read More

    Flow cytometry minimal residual disease after allogeneic transplant for chronic lymphocytic leukemia.
    Eur J Haematol 2016 Dec 10. Epub 2016 Dec 10.
    Hématologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
    Objectives: This study investigates whether achieving complete remission (CR) with undetectable minimal residual disease (MRD) after allogeneic stem cell transplantation (allo-SCT) for chronic lymphocytic leukemia (CLL) affects outcome.

    Methods: We retrospectively studied 46 patients transplanted for CLL and evaluated for post-transplant MRD by flow cytometry.

    Results: At transplant time, 43% of the patients were in CR, including one with undetectable MRD, 46% were in partial response, and 11% had refractory disease. Read More

    A multicentre study of 95 biopsy-proven cases of renal disease in primary Sjögren's syndrome.
    Rheumatology (Oxford) 2016 Dec 10. Epub 2016 Dec 10.
    Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP-HP, Université Paris Descartes, Paris.
    Objective: Renal involvement is a rare event during primary SS (pSS). We aimed to describe the clinico-biological and histopathological characteristics of pSS-related nephropathy and its response to treatment.

    Methods: We conducted a French nationwide, retrospective, multicentre study including pSS patients fulfilling American-European Consensus Group criteria or enlarged American-European Consensus Group criteria, and with biopsy-proven renal involvement. Read More

    Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.
    Gastroenterology 2016 Dec 7. Epub 2016 Dec 7.
    Unité Mixte de Recherche, Génomique Fonctionnelle des Tumeurs Solides, Institut National de la Santé et de la Recherche Médicale, Paris, France. Electronic address:
    Background & Aims: Hepatocellular adenomas (HCAs) are benign liver tumors that can be assigned to molecular subtypes based on inactivating mutations in hepatocyte nuclear factor 1A, activating mutations in β-catenin, or activation of inflammatory signaling pathways. We aimed to update the classification system for HCA and associate the subtypes with disease risk factors and complications.

    Methods: We analyzed expression levels of 20 genes and sequenced exon regions of 8 genes (HNF1A, IL6ST, CTNNB1, FRK, STAT3, GNAS, JAK1, and TERT) in 607 samples of 533 HCAs from 411 patients, collected from 28 centers mainly in France from 2000 and 2014. Read More

    Ischemic myopathy revealing systemic calciphylaxis.
    Muscle Nerve 2016 Dec 9. Epub 2016 Dec 9.
    Reference Center for Neuromuscular Diseases, Hôpital Henri Mondor APHP (Assistance Publique des Hôpitaux de Paris); INSERM U955-Team 10, Université Paris Est-Créteil, Créteil, France.
    Introduction: Patients with renal failure who are being treated with dialysis frequently develop neuromuscular manifestations. Renal failure-associated calciphylaxis, also termed calcific uremic arteriolopathy (CUA), is a life-threatening condition usually observed in patients with end-stage renal disease on chronic dialysis or following renal transplantation.

    Methods: We describe a hemodialyzed patient who presented with rapidly progressive unexplained systemic vasculopathy, muscle atrophy, and proximal weakness, that unexpectedly proved to be caused by calciphylaxis. Read More

    Prevalence and prognostic impact of left-sided valve thickening in systemic light-chain amyloidosis.
    Clin Res Cardiol 2016 Dec 8. Epub 2016 Dec 8.
    Department of Hematology, French National Reference Center of AL Amyloidosis Pôle «Onco-Hématologie», CHU Dupuytren, Limoges, France.
    Background: Left heart valve thickening (LVT) was described in patients with light-chain amyloidosis (AL). This phenomenon reflects likely infiltration of the valve by amyloid proteins. However, the prevalence of LVT and its prognostic value have not been investigated in patients with AL. Read More

    Adaptive Radiotherapy for an Uncommon Chloroma.
    Case Rep Oncol 2016 Sep-Dec;9(3):593-598. Epub 2016 Oct 12.
    Department of Radiation Oncology and Henri Mondor Breast Center, INSERM U955 E07, and University of Paris-Est Créteil (UPEC), Créteil, France.
    Granulocytic sarcomas, also referred to as chloromas or myeloid sarcomas, are extramedullary neoplasms that are composed of immature myeloid cells. This uncommon disease is known to be radiosensitive. However, the total dose and dose per fraction are not standardized. Read More

    Hallucinations in schizophrenia and Parkinson's disease: an analysis of sensory modalities involved and the repercussion on patients.
    Sci Rep 2016 Dec 1;6:38152. Epub 2016 Dec 1.
    CHU Clermont-Ferrand, Psychiatry B, Clermont-Ferrand, F-63003, France.
    Hallucinations have been described in various clinical populations, but they are neither disorder nor disease specific. In schizophrenia patients, hallucinations are hallmark symptoms and auditory ones are described as the more frequent. In Parkinson's disease, the descriptions of hallucination modalities are sparse, but the hallucinations do tend to have less negative consequences. Read More

    [Mindfulness-based interventions in obsessive-compulsive disorder: Mechanisms of action and presentation of a pilot study].
    Encephale 2016 Nov 22. Epub 2016 Nov 22.
    Inserm U 1127, CNRS UMR 7225, Team Behavior, Emotion, and Basal Ganglia, institut du cerveau et de la moelle épinière (ICM), université Pierre-et-Marie-Curie (UPMC), Paris, France.
    Obsessive-compulsive disorder (OCD) is a frequent and severe disease, potentially inducing a major impairment for the patient and burden for their family. Recent research in psychiatry and neuroscience have led to better comprehension of the disease's mechanisms and helped to improve its treatment. However, a large proportion of patients have refractory symptoms, including for traditional cognitive and behavioral therapy by exposure and response prevention (ERP), leading clinicians to look for new treatments. Read More

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