4,383 results match your criteria Monaldi Archives for Chest Disease [Journal]


Advanced Non Small Cell Lung Cancer with activating Epidermal Growth Factor Receptor mutation: First line treatment and beyond.

Rev Recent Clin Trials 2018 Dec 5. Epub 2018 Dec 5.

Division of Medical Oncology, AORN Giuseppe Moscati, Avellino. Italy.

Background: Lung cancer is the leading cause of cancer mortality, being responsible for more than 1.6 million deaths each year worldwide and non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancers; moreover, 10 to 15% of all NSCLCs harbors EGFR (epidermal growth factor receptor) activating mutations, being suitable for EGFR-Tyrosine Kinase Inhibitors (TKI) molecular targeted therapy. However, EGFR+ NSCLCs gain acquired resistance to these agents, representing one of the key challenges for modern precision oncology. Read More

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December 2018

Remote Monitoring of Atrial High Rate Episodes in Pacemaker Patients. The Rapid Study Design.

J Atr Fibrillation 2018 Aug 31;11(2):2075. Epub 2018 Aug 31.

Departmental Unit of Electrophysiology, Evaluation and Treatment of Arrhythmias, Monaldi Hospital, Naples, Italy.

Background: Remote Monitoring (RM) has been introduced for several years and nowadays most pacemakers are equipped with such a technology. RM can provide early detection of high atrial rate episodes (AHREs) onset and enable prompt medical intervention. However, there are still little data on the clinical reactions triggered by the AHRE detected by RM of pacemaker recipients and on their possible benefit on patients' outcome. Read More

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Prostaglandin D receptor antagonists in allergic disorders: safety, efficacy and future perspectives.

Expert Opin Investig Drugs 2018 Dec 4. Epub 2018 Dec 4.

c Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI) , University of Naples Federico II , Naples , Italy.

Introduction: Prostaglandin D (PGD) is a major cyclooxygenase mediator that is synthesized by activated human mast cells and other immune cells. The biological effects of PGD are mediated by D-prostanoid (DP), DP (CRTH2) and thromboxane prostanoid (TP) receptors that are expressed on several immune and non-immune cells involved in allergic inflammation. PGD exerts various proinflammatory effects relevant to the pathophysiology of allergic disorders. Read More

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December 2018
2 Reads

Nivolumab in never-smokers with advanced squamous non-small cell lung cancer: Results from the Italian cohort of an expanded access program.

Tumour Biol 2018 Nov;40(11):1010428318815047

21 AO dei Colli-Monaldi-Cotugno-CTO, Napoli, Italy.

Objectives:: Never-smokers may be a distinct subgroup among patients with advanced non-small cell lung cancer, appearing to benefit less from immunotherapy than smokers. We report results from never-smokers enrolled in the Italian cohort of the nivolumab expanded access program in pre-treated patients with advanced squamous non-small cell lung cancer.

Materials And Methods:: Nivolumab (3 mg/kg every 2 weeks for ≤24 months) was available on physician request. Read More

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November 2018

Utility of peripheral blood smear in rapid diagnosis of Pertussis.

Int J Lab Hematol 2018 Nov 27. Epub 2018 Nov 27.

A.O.R.N. "G. Rummo" Benevento, U.O. Patologia Clinica, Benevento, Italy.

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November 2018

Mutations in the GLA Gene and LysoGb3: Is It Really Anderson-Fabry Disease?

Int J Mol Sci 2018 Nov 23;19(12). Epub 2018 Nov 23.

Institute of Biomedicine and Molecular Immunology "A. Monroy", National Research Council, 90146 Palermo, Italy.

Anderson-Fabry disease (FD) is a rare, progressive, multisystem storage disorder caused by the partial or total deficit of the lysosomal enzyme α-galactosidase A (α-Gal A). It is an X-linked, lysosomal enzymopathy due to mutations in the galactosidase alpha gene (GLA), encoding the α-Gal A. To date, more than 900 mutations in this gene have been described. Read More

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November 2018
7 Reads

Treatment outcomes of colistin and carbapenem-resistant Acinetobacter baumannii infections: an exploratory subgroup analysis of a randomized clinical trial.

Clin Infect Dis 2018 Nov 20. Epub 2018 Nov 20.

Institute of Infectious Diseases, Rambam Health Care Campus, Haifa, Israel.

Background: We aimed to evaluate the association between mortality and colistin-resistance in infections caused by Acinetobacter baumannii and the interaction with antibiotic therapy.

Methods: This is a secondary analysis of a randomized controlled trial of patients with carbapenem-resistant Gram-negative bacterial infections treated with colistin or colistin-meropenem combination. We evaluated patients with infection caused by carbapenem-resistant A. Read More

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November 2018
4 Reads

Early diagnosis and management of cardiac manifestations in mucopolysaccharidoses: a practical guide for paediatric and adult cardiologists.

Ital J Pediatr 2018 Nov 16;44(Suppl 2):122. Epub 2018 Nov 16.

U.O. Cardiologia Pediatrica e U.O. di Riabilitazione e Scompenso Cardiaco, Ospedale Monaldi, A.O. dei Colli, Dipartimento di Scienze Cardio-Toraciche e Respiratorie, Università della Campania Luigi Vanvitelli, Via Leonardo Bianchi, 80131, Naples, Italy.

Mucopolysaccharidoses (MPS) are a group of hereditary disorders caused by lysosomal storage of glycosaminoglycans (GAGs) and characterized by a wide variability of phenotypes from severe fetal-neonatal forms to attenuated diseases diagnosed in adult individuals. The clinical picture generally worsens with age due to progressive storage involving mucosal tissue, upper airways and lungs, bones and joints, central and peripheral nervous system, heart, liver, eye, and ear. Cardiac storage of GAGs involves valves, heart muscle, and vessels (particularly the coronary arteries), and can be specific in relation to different MPS types and enzyme defects. Read More

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November 2018
5 Reads

Risk Stratification of Sudden Cardiac Death in Patients with Heart Failure: An update.

J Clin Med 2018 Nov 10;7(11). Epub 2018 Nov 10.

Heart Failure Unit, AORN dei Colli, Monaldi Hospital, 80121 Naples, Italy.

Heart failure (HF) is a complex clinical syndrome in which structural/functional myocardial abnormalities result in symptoms and signs of hypoperfusion and/or pulmonary or systemic congestion at rest or during exercise. More than 80% of deaths in patients with HF recognize a cardiovascular cause, with most being either sudden cardiac death (SCD) or death caused by progressive pump failure. Risk stratification of SCD in patients with HF and preserved (HFpEF) or reduced ejection fraction (HFrEF) represents a clinical challenge. Read More

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November 2018
5 Reads

Organizational model and reactions to alerts in remote monitoring of cardiac implantable electronic devices: a survey from the Home Monitoring Expert Alliance (HMEA) project.

Clin Cardiol 2018 Nov 12. Epub 2018 Nov 12.

CardioArrhythmology Center, Rome, Italy.

Background: This survey aimed to describe the organizational workflow of cardiac implantable electronic devices (CIEDs) remote monitoring (RM) service in ordinary practice.

Methods: A questionnaire was designed for our purpose and completed by 49 sites participating to the Italian Home Monitoring Expert Alliance.

Results: A dedicated organizational model for RM was set up for 86% of centers. Read More

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November 2018
5 Reads

Hemodynamic changes after acute fluid loading in patients with systemic sclerosis without pulmonary hypertension.

Pulm Circ 2019 Jan-Mar;9(1):2045894018816089. Epub 2018 Nov 13.

1 Cardiology, University "L. Vanvitelli" - Monaldi Hospital, Naples, Italy.

A fluid challenge with a rapid infusion of saline helps to discriminate between pre- and post-capillary pulmonary hypertension (PH) and allows unmasking hidden post-capillary PH. Systemic sclerosis (SSc) patients may present with biventricular systolic and diastolic dysfunction. The aim of this study was to evaluate the hemodynamic changes of the pulmonary circulation in SSc patients without PH after a fluid challenge. Read More

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November 2018

Epigenetic Hallmarks of Fetal Early Atherosclerotic Lesions in Humans.

JAMA Cardiol 2018 Nov 7. Epub 2018 Nov 7.

Institute of Diagnostic and Nuclear Research, Istituto di Ricovero e Cura a Carattere Scientifico, Naples, Italy.

Importance: Although increasingly strong evidence suggests a role of maternal total cholesterol and low-density lipoprotein cholesterol (LDLC) levels during pregnancy as a risk factor for atherosclerotic disease in the offspring, the underlying mechanisms need to be clarified for future clinical applications.

Objective: To test whether epigenetic signatures characterize early fetal atherogenesis associated with maternal hypercholesterolemia and to provide a quantitative estimate of the contribution of maternal cholesterol level to fetal lesion size.

Design, Setting, And Participants: This autopsy study analyzed 78 human fetal aorta autopsy samples from the Division of Human Pathology, Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy. Read More

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November 2018
7 Reads

Pediatric musculoskeletal ultrasound: a pictorial essay.

J Ultrasound 2018 Nov 9. Epub 2018 Nov 9.

Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.

Ultrasound (US) is the main imaging modality for the evaluation of pediatric patients with musculoskeletal diseases; particularly, it is an appropriate and reliable tool for diagnosis, follow-up and treatment of several musculoskeletal pathologies affecting the pediatric age. High-frequency (10-15 MHz) and high-resolution probes provide very lofty quality images, allowing a detailed study of the pediatric musculoskeletal system. Among the well-known advantages of this technique-such as the absence of ionizing radiations, its low cost and wide availability-US can as well rely on some intrinsic characteristics of the pediatric musculoskeletal system that can improve its diagnostic capability. Read More

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November 2018
8 Reads

A case of bleomycin-induced lung toxicity.

Monaldi Arch Chest Dis 2018 Nov 6;88(3):981. Epub 2018 Nov 6.

Istanbul University, Cerrahpasa Medical Faculty, Pulmonary Diseases Department.

A 64-year-old female was admitted for dry cough, dyspnea, fever, loss of appetite, and weight loss. Past medical history revealed scoliosis, cholecystectomy, and Hodgkin lymphoma. ABG values were: pH: 7. Read More

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November 2018

Perioperative Medication Management in Adult Cardiac Surgery: The 2017 European Association for Cardio-Thoracic Surgery Guidelines.

J Cardiothorac Vasc Anesth 2018 Sep 27. Epub 2018 Sep 27.

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.

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September 2018
1 Read

A case of pulmonary edema: The critical role of lung-heart integrated ultrasound examination.

Monaldi Arch Chest Dis 2018 Oct 1;88(3):982. Epub 2018 Oct 1.

CTO Hospital, Emergency Department.

Cardiogenic pulmonary edema is a common presentation of acute heart failure normally treated with continuous positive airway pressure (CPAP), diuretics and nitrates. This therapy is contraindicated in case of cardiac tamponade. We describe a case of pulmonary edema due to cardiac tamponade in which integrated lung-heart ultrasound examination allowed prompt diagnosis and pericardiocentesis before administration of CPAP thus avoiding circulatory collapse. Read More

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October 2018
2 Reads

Deep sedation versus minimal sedation during endobronchial ultrasound transbronchial needle aspiration.

Monaldi Arch Chest Dis 2018 Oct 3;88(3):967. Epub 2018 Oct 3.

Hospital of Vittorio Veneto, Pulmonary Diseases Unit.

The sedation plays an important role in the endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) procedure. The sedation can be Minimal (anxiolysis), Moderate (conscious sedation) or Deep. The ACCP guidelines suggest that moderate or deep sedation (DS) is an acceptable approach. Read More

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October 2018
1 Read

The impact of gender in cardiovascular medicine: Lessons from the gender/sex-issue in heart failure.

Monaldi Arch Chest Dis 2018 Oct 11;88(3):988. Epub 2018 Oct 11.

IRCCS SDN, Naples.

Heart Failure (HF) is a major healthcare issue, given its high prevalence and incidence, the rate of comorbidities, the related high health-care costs and its poor outcome. In the last years mounting evidence revealed several differences between men and women affected by this clinical condition. Apart from the well-known difference in phenotype (HF with reduced ejection fraction (HFrEF) occurs more commonly in men, and HF with preserved ejection fraction (HFpEF) is more frequent in women) other relevant sex-related issues dwell upon epidemiology, presentation, risk stratification and management. Read More

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October 2018

Cardiac Prevention and Rehabilitation "3.0": From acute to chronic phase. Position Paper of the ltalian Association for Cardiovascular Prevention and Rehabilitation (GICR-IACPR).

Monaldi Arch Chest Dis 2018 Oct 26;88(3):1004. Epub 2018 Oct 26.

U.O. Cardiologia Riabilitativa, Dipartimento di Cardioangiologia Riabilitativa, Istituti Clinici Scientifici Maugeri, IRCCS di Pavia.

Cardiac rehabilitation (CR) is the subspecialty of clinical cardiology dedicated to the treatment of cardiac patients, early and in the long term after an acute event. The aim of CR is to improve both quality of life and prognosis through prognostic stratification, clinical stabilization and optimization of therapy (pharmacological and non), management of comorbidities, treatment of disability, as well as through the provision and reinforcement of secondary prevention interventions and maintenaince of adherence to treatment. The mission of CR has changed over time. Read More

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October 2018
7 Reads

Acquired tracheoesophageal fistula repair, due to prolonged mechanical ventilation, in patient with double incomplete aortic arch.

Monaldi Arch Chest Dis 2018 Oct 30;88(3):974. Epub 2018 Oct 30.

University of Padua, Department of Cardiologic, Thoracic and Vascular Sciences.

We report a case of the repair of an acquired benign tracheoesophageal fistula (TEF) after prolonged mechanical invasive ventilation. Patient had an unknown double incomplete aortic arch determining a vascular ring above trachea and esophagus. External tracheobronchial compression, caused by the vascular ring, increasing the internal tracheoesophageal walls pressure determined by endotracheal and nasogastric tubes favored an early TEF development. Read More

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October 2018
3 Reads

Permanent atrial fibrillation and pulmonary embolism in elderly patients without deep vein thrombosis: is there a relationship?

Aging Clin Exp Res 2018 Oct 29. Epub 2018 Oct 29.

Department of Translational Medical Sciences, University of Naples Federico II, Via S. Pansini, 80131, Naples, Italy.

Background And Aim: Permanent Atrial Fibrillation (pAF) is associated with increased risk of embolic complications. The relationship between pAF and pulmonary embolism (PE) has not been extensively investigated in elderly patients. Here, we aim at verifying whether pAF is associated to an increased risk of PE in a cohort of elderly patients with and without Deep Vein Thrombosis (DVT). Read More

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October 2018

Effectiveness of the 2014 European Society of Cardiology guideline on sudden cardiac death in hypertrophic cardiomyopathy: a systematic review and meta-analysis.

Heart 2018 Oct 26. Epub 2018 Oct 26.

The Inherited Cardiac Diseases Unit, Barts Heart Centre, St Bartholomew's Hospital, London, UK.

Objective: In 2014, the European Society of Cardiology (ESC) recommended the use of a novel risk prediction model (HCM Risk-SCD) to guide use of implantable cardioverter defibrillators (ICD) for the primary prevention of sudden cardiac death (SCD) in patients with hypertrophic cardiomyopathy (HCM). We sought to determine the performance of HCM Risk-SCD by conducting a systematic review and meta-analysis of articles reporting on the prevalence of SCD within 5 years of evaluation in low, intermediate and high-risk patients as defined by the 2014 guidelines (predicted risk <4%, 4%-<6% and ≥6%, respectively).

Methods: The protocol was registered with PROSPERO (registration number: CRD42017064203). Read More

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October 2018
12 Reads

Use and Outcomes of Subcutaneous Implantable Cardioverter Defibrillator (ICD) After Trans-venous ICD Extraction: an Analysis of Current Clinical Practice and a Comparison with Trans-venous ICD Reimplantation.

Heart Rhythm 2018 Oct 23. Epub 2018 Oct 23.

Second Cardiology Division, University Hospital of Pisa, Italy.

Background: The subcutaneous implantable cardioverter-defibrillator (S-ICD) does not require the insertion of any leads into the cardiovascular system.

Objective: This analysis describes current practice concerning S-ICD use after transvenous ICD (TV-ICD) explantation.

Methods: We analyzed all consecutive patients who underwent transvenous extraction of an ICD and subsequent implantation of an S-ICD or a single-chamber TV-ICD at 12 Italian centers from 2011 to 2017. Read More

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October 2018
7 Reads

Predictors of outcome in heart failure patients with severe functional mitral regurgitation undergoing MitraClip treatment.

Int J Cardiol 2018 Oct 17. Epub 2018 Oct 17.

Cardiology Unit, Cardiovascular and Thoracic Department, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy. Electronic address:

Background: The prognostic predictors of outcome in patients with functional mitral regurgitation (FMR) undergoing MitraClip implantation (MCi) are still poorly known. The aim of our study is to identify the baseline predictors of outcome in FMR patients candidate to MCi.

Methods: All patients with symptomatic moderate-to-severe or severe FMR undergoing MCi at our institution were consecutively and prospectively enrolled. Read More

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October 2018
1 Read

Budget Impact Analysis of a Biosynthetic Mesh for Incisional Hernia Repair.

Clin Ther 2018 Nov 20;40(11):1830-1844.e4. Epub 2018 Oct 20.

Azienda Ospedaliero Universitaria, Ferrara, Italy.

Purpose: With the development of newer prostheses for hernia repair, it is nowadays difficult to understand the total cost of managing patients treated with these advanced medical devices, especially in the complex abdomen, in which various complications may occur. The aim of this study was to determine the economic implications of these prostheses in order to inform decision making in the management of incisional hernia repair.

Methods: A budget impact analysis model was developed to evaluate the economic consequences related to the management of patients undergoing complex (Centers for Disease Control and Prevention wound class II-III or Ventral Hernia Working Group grade 2/3) incisional hernia repair through biosynthetic, synthetic, or biological meshes, from the hospital perspective in Italy. Read More

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November 2018
6 Reads

One-year clinical performance of ABSORB bioresorbable vascular scaffold in patients presenting with acute coronary syndromes: Results from the RAI registry.

Catheter Cardiovasc Interv 2018 Oct 22. Epub 2018 Oct 22.

Interventional Cardiology Unit, "Santi Croce e Carle" Hospital, Cuneo, Italy.

Objectives: To report 1-year clinical outcomes of bioresorbable vascular scaffold (BVS) in acute coronary syndromes (ACS) population.

Background: BVS use has rapidly extended to high-risk patients as those presenting with ACS. To date limited data have been reported on BVS performance in ACS patients. Read More

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October 2018
1 Read

Patent foramen ovale with complex anatomy: Comparison of two different devices (Amplatzer Septal Occluder device and Amplatzer PFO Occluder device 30/35).

Int J Cardiol 2018 Oct 16. Epub 2018 Oct 16.

Paediatric Cardiology, University of Campania "Luigi Vanvitelli", Monaldi Hospital, Naples, Italy.

Background: Patent foramen ovale (PFO) closure after a cryptogenic cerebral ischemic event is a routinely procedure. The most used device is Amplatzer™ PFO Occluder 25mm, but PFOs with complex anatomy require larger device for closure. We compared Amplatzer™ Septal Occluder (ASO) device versus Amplatzer™ PFO Occluder 30 or 35mm (A-PFO 30/35) about the safety of procedure and the presence of residual shunt during the follow-up. Read More

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October 2018
3 Reads

Gastroduodenal Disorders in Patients with CVID Undergoing Immuno-globulin Therapy.

Curr Pharm Biotechnol 2018 Oct 10. Epub 2018 Oct 10.

University of Naples Federico II, Naples, Italy - Department of Translational Medical Sciences (DiSMeT) Naples. Italy.

Background: Common variable immunodeficiency (CVID) encompasses a heterogeneous group of primary antibody deficiency disorders characterized by recurrent infections, autoimmunity and malignancies. Gastrointestinal manifestations are frequently associated with CVID.

Objective: In this cross-sectional study, we evaluated gastric and duodenal involvement in a cohort of adult patients with CVID. Read More

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October 2018
6 Reads

Seasonal trend of ventricular arrhythmias in a nationwide remote monitoring database of implantable defibrillators and cardiac resynchronization devices.

Int J Cardiol 2018 Oct 10. Epub 2018 Oct 10.

Departmental Unit of Electrophysiology, Evaluation and Treatment of Arrhythmias, Monaldi Hospital, Napoli, Italy.

Background: The occurrence of sustained ventricular arrhythmias (SVA) may be influenced by environmental factors. We aimed to investigate annual periodic trends of SVA from the intracardiac electrograms (IEGMs) stored in the implantable defibrillators (ICDs) or cardiac resynchronization therapy (CRT-D) recipients.

Methods: Data from the Home Monitoring Expert Alliance project, a pooled repository of remote monitoring transmissions were analyzed. Read More

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October 2018
1 Read

Abiraterone acetate treatment in patients with castration-resistant prostate cancer with visceral metastases: a real-world experience.

Anticancer Drugs 2018 Oct 12. Epub 2018 Oct 12.

Departmental Unit of Clinical and Experimental Uro-Andrologic Oncology, Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale.

In the pre-chemotherapy (CT) and post-CT settings of metastatic castration-resistant prostate cancer (mCRPC), abiraterone acetate plus prednisone (AAP) significantly extended median overall survival and radiographic progression-free survival (PFS) compared with prednisone alone. Yet, few data are available on therapy efficacy in the subgroup with visceral metastases, who represent a small population with poor prognosis. The aim of this study was to describe the clinical experience of AAP in patients with mCRPC with liver and/or lung metastases in real-world setting. Read More

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October 2018
3 Reads

Laparoscopic near-total splenectomy: a single-center experience of a standardized procedure.

Minim Invasive Ther Allied Technol 2018 Oct 11:1-6. Epub 2018 Oct 11.

a Department of Laparoscopic and Robotic General Surgery , Azienda Ospedaliera dei Colli "Monaldi Hospital" , Naples , Italy.

Background: Near-total splenectomy (NTS) represents an innovative and effective surgery technique for spleen disease, reducing the risk of severe infections and thromboembolic events after total splenectomy. The authors reported a laparoscopic near-total splenectomy (LNTS) surgical experience following the optimal results of the open approach, describing a standardized and effective minimally invasive technique with the purpose of preserving a minimal residual spleen.

Material And Methods: From November 2006 to September 2016, 15 patients with splenic and hematologic disease underwent LNTS, according to a laparoscopic procedure developed by the authors. Read More

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October 2018
1 Read

Combining VITEK 2 with colistin agar dilution screening assist timely reporting of colistin susceptibility.

Clin Microbiol Infect 2018 Oct 4. Epub 2018 Oct 4.

Molecular Epidemiology Laboratory, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; National Laboratory for Antibiotic Resistance and Investigation of Outbreaks in Medical Institutions, National Institute for Antibiotic Resistance and Infection Control, Ministry of Health, Israel; Sackler Faculty of Medicine, Tel Aviv University, Ramat-Aviv, Israel.

Objectives: The rise in carbapenem resistance among Gram-negative bacteria has renewed interest in colistin. Recently, the EUCAST-CLSI Polymyxin Breakpoints Working Group declared that broth microdilution (BMD) is the only valid method for colistin susceptibility testing. BMD is not easily incorporated into the routine work of clinical laboratories, and usually this test is incorporated serially, resulting in delayed susceptibility reporting. Read More

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October 2018
13 Reads

[Appropriateness criteria for the management of anticoagulant therapy in complex patients with atrial fibrillation. The opinion of a group of expert Italian cardiologists].

G Ital Cardiol (Rome) 2018 Oct;19(10):591-600

S.C. Cardiologia, AOU Policlinico, Modena.

Atrial fibrillation (AF) is a common arrhythmia often associated with high thromboembolic risk. The purpose of this position paper is to provide clinicians with recommendations useful in managing some important issues regarding the use of anticoagulant therapy in patients with AF in particularly complex clinical situations.The RAND/UCLA appropriateness method, validated to combine the best available scientific evidence with the collective judgment of experts, was used to assess the judgment of an expert panel of cardiologists. Read More

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October 2018
3 Reads

Performance analysis of SiRe next-generation sequencing panel in diagnostic setting: focus on NSCLC routine samples.

J Clin Pathol 2018 Oct 2. Epub 2018 Oct 2.

Department of Public Health, University of Naples Federico II, Naples, Italy.

Aims: Following the development for liquid biopsies of the SiRe next-generation sequencing (NGS) panel that covers 568 clinical relevant mutations in and genes, in this current study, we apply this small NGS panel on tissue samples of lung cancer.

Methods: A total of 322 specimens were prospectively tested. Technical parameters were analysed on both cytological and histological samples. Read More

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October 2018
2 Reads

Remote monitoring of subcutaneous implantable cardioverter defibrillators.

J Interv Card Electrophysiol 2018 Oct 1. Epub 2018 Oct 1.

Marche Polytechnic University, Ancona, Italy.

Background: Remote monitoring (RM) of implantable cardioverter defibrillators (ICD) has been shown to improve patient safety and reduce in-office visits. The subcutaneous ICD (S-ICD) is an effective alternative to transvenous ICD and has recently been endowed with the RM function. However, the RM communicator for S-ICD requires patient interaction to activate data transmission. Read More

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October 2018
10 Reads

The 2015 World Health Organization Classification of lung tumors: new entities since the 2004 Classification.

Pathologica 2018 Mar;110(1):39-67

Pathology Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy.

In the last few years different new pulmonary neoplastic lesions have been recognised and some of them, namely NUT carcinoma, PEComatous tumors, pneumocytic adenomyoepithelioma, pulmonary myxoid sarcoma, myoepithelial tumors/carcinomas entered in the last 2015-WHO classification of lung tumors. In addition angiomatoid fibrous histiocytoma and ciliated muconodular papillary tumor have been morphologically and genetically characterized albeit not yet included in the 2015-WHO classification.

In the present paper we summarised the clinical, morphological, immunohistochemical and molecular features of these new entities. Read More

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March 2018
1 Read

Quality control of B-lines analysis in stress Echo 2020.

Cardiovasc Ultrasound 2018 Sep 25;16(1):20. Epub 2018 Sep 25.

CNR, Institute of Clinical Physiology, Biomedicine Department, Pisa, Italy.

Background: The effectiveness trial "Stress echo (SE) 2020" evaluates novel applications of SE in and beyond coronary artery disease. The core protocol also includes 4-site simplified scan of B-lines by lung ultrasound, useful to assess pulmonary congestion.

Purpose: To provide web-based upstream quality control and harmonization of B-lines reading criteria. Read More

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September 2018
13 Reads
1.280 Impact Factor

Coital Incontinence in Women With Urinary Incontinence: An International Study.

J Sex Med 2018 Oct 20;15(10):1456-1462. Epub 2018 Sep 20.

Department of Surgical and Biomedical Science, Andrological and Urogynecological Clinic, University of Perugia, Terni, Italy. Electronic address:

Introduction: Coital urinary incontinence (CUI) is not much explored during clinical history, and this could lead to an underestimation of the problem.

Aim: To evaluate the prevalence and clinical risk factors of CUI in women with urinary incontinence (UI), and to measure the impact of CUI on women's sexuality and quality of life.

Methods: This was a multicenter international study, conducted in Italy, Greece, the United States, and Egypt. Read More

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October 2018
7 Reads
3.150 Impact Factor

Latest News on relationship between thunderstorms and respiratory allergy, severe asthma, and deaths for asthma.

Allergy 2018 Sep 22. Epub 2018 Sep 22.

First Division of Pneumology, High Speciality Hospital "V. Monaldi" and University, Federico II" Medical School, Napoli, Italy.

Thunderstorm asthma (TA) refers to the sudden increase of acute bronchospasm following a storm during pollen seasons, necessitating primary care facilities by general practioner (GP) visits, Emergency Department (ED) admissions and hospitalizations, sometimes also endotracheal intubation for severe asthma and near fatal asthma (NFA). In the scientific literature, there are descriptions of epidemics of TA in various geographical areas of the world (1-8) and climate change scenarios indicate there will be an increase in the intensity and frequency of heavy rainfall episodes, including thunderstorms, in all the world. This article is protected by copyright. Read More

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September 2018

Continuous noninvasive ventilation for respiratory failure in patients with amyotrophic lateral sclerosis: current perspectives.

Degener Neurol Neuromuscul Dis 2018 4;8:55-61. Epub 2018 Sep 4.

Intensive Care Unit, Morales Meseguer Hospital, Murcia, Spain.

Respiratory failure is a recognized late complication of amyotrophic lateral sclerosis. It is related to the neurological progression of the diseases with the impairment of the respiratory musculature. Survival and quality of life of amyotrophic lateral sclerosis patients is improved by using noninvasive mechanical ventilation. Read More

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September 2018
9 Reads

Conversion to thoracotomy during VATS segmentectomy for treatment of symptomatic endobronchial hamartoma.

Int J Surg Case Rep 2018 12;51:272-274. Epub 2018 Sep 12.

Division of Thoracic Surgery, Monaldi Hospital, Leonardo Bianchi Street, 80131, Naples, Italy.

Introduction: Most hamartomas are located peripherally in the lung parenchyma and are rarely identified as an endobronchial lesion. Clinically patients with an endobronchial hamartoma are often symptomatic and may present with various symptoms including: fever, wheezing, hemoptysis and obstructive pneumonia.

Case Presentation: A 68-year-old man presented with complaints of fever and cough for 1 month. Read More

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September 2018

Subcutaneous implantable cardioverter defibrillator in cardiomyopathies and channelopathies.

J Cardiovasc Med (Hagerstown) 2018 Nov;19(11):633-642

Department of Cardiac, Thoracic and Vascular Sciences, University of Padova.

: Cardiomyopathies and channelopathies are heterogeneous disorders that increase the risk of sudden cardiac death (SCD). Implantable cardioverter-defibrillator (ICD) therapy is safe and effective for preventing SCD in patients at risk for malignant ventricular arrhythmias. Because of the poor positive predictive value of current risk stratification tools, the majority of patients implanted with an ICD will never receive a life-saving therapy but will be exposed to the risk of complications such as device infection, lead failure and inappropriate therapy. Read More

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November 2018
2 Reads

The stricter criteria for Class I CRT indication suggested by the 2016 ESC Guidelines reliably exclude patients with a worse prognosis in comparison with the 2013 ESC indication criteria.

Int J Cardiol 2018 Dec 8;273:162-167. Epub 2018 Sep 8.

Mediterranean Clinic, Naples, Italy.

Background: The European Society of Cardiology (ESC) Guidelines published in 2016 modified indications for cardiac resynchronization therapy (CRT) in comparison with the 2013 ESC Guidelines. The aim of this analysis was to evaluate the impact of the stricter criteria suggested by the 2016 ESC Guidelines on patient outcome in a real-world population.

Methods: We collected data on 930 consecutive patients with complete outcome information who had undergone CRT implantation from 2011 to 2013 from the CRT-MORE registry. Read More

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December 2018

Transcatheter Repair of Functional Mitral Regurgitation in Heart Failure Patients - A Meta-Analysis of 23 Studies on MitraClip Implantation.

Circ J 2018 Oct 13;82(11):2800-2810. Epub 2018 Sep 13.

Cardiology Unit, Cardiovascular and Thoracic Department, University Hospital "San Giovanni di Dio e Ruggi d'Aragona".

Background: The aim of this study was to investigate long-term survival, clinical status, and echocardiographic findings of patients with severe functional mitral regurgitation (FMR) undergoing MitraClip (MC) treatment and to explore the role of baseline features on outcome. Methods and Results: Randomized and observational studies of FMR patients undergoing MC treatment were collected to evaluate the overall survival, New York Heart Association (NYHA) class and echocardiographic changes after MC treatment. Baseline parameters associated with mortality and echocardiographic changes were also investigated. Read More

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October 2018
11 Reads

Exogenous lipoid pneumonia associated with oil pulling: Report of two cases.

Monaldi Arch Chest Dis 2018 Sep 7;88(3):922. Epub 2018 Sep 7.

Grantham Hospital, TB and Chest Unit.

Two ladies with history of carcinoma of tongue presenting with un-resolving pneumonia were ultimately diagnosed to have lipoid pneumonia, and both were subsequently found to be associated with the practice of oil pulling which is a popular complementary therapy. Apart from cessation of oil pulling, they were treated with repeated therapeutic lobar broncho-alveolar lavage. despite the potential benefits of oil pulling on oral health, people especially those at risk of aspiration, should be properly informed of this potential risk when considering this form of complementary therapy. Read More

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September 2018
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An unexpected complication of a percutaneous coronary angioplasty.

Monaldi Arch Chest Dis 2018 Sep 7;88(3):969. Epub 2018 Sep 7.

-"Sapienza" University, Department of Cardiovascular, Respiratory, Nephrological, Anesthetic and Geriatric Sciences -Policlinico Casilino, Department of Cardiology.

Takotsubo cardiomyopathy (TCM) is characterized by transient ventricular dysfunction, classically in its apical and mid segments, in the absence of coronary lesions, and is often observed after intense stressful events and occasionally associated to an acute medical illness. We describe a case of TCM associated with coronary artery disease and triggered by a percutaneous coronary angioplasty. This case highlights the concept that a medical procedure can lead, in certain conditions, to TCM and provides new interesting insights on the pathophysiology of coronary syndromes. Read More

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September 2018

The value of exfoliative cell cytology in the diagnosis of exudative pleural effusions.

Monaldi Arch Chest Dis 2018 Sep 11;88(3):944. Epub 2018 Sep 11.

Istanbul University, Cerrahpasa Medical Faculty, Pulmonary Diseases Department.

The sensitivity and specificity of exfoliative cell cytology for the diagnosis of exudative pleural effusions varies widely according to the etiologic causes. The aim of this study is to assess the diagnostic value of exfoliative cell cytology for the identification of exudative pleural effusions. This is a retrospective study of the patients with an exudative pleural effusion admitted at our clinic in the last twenty years. Read More

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September 2018
11 Reads

Frontal brain asymmetries as effective parameters to assess the quality of audiovisual stimuli perception in adult and young cochlear implant users.

Acta Otorhinolaryngol Ital 2018 Aug;38(4):346-360

Department of Molecular Medicine, Sapienza University of Rome, Italy.

How is music perceived by cochlear implant (CI) users? This question arises as "the next step" given the impressive performance obtained by these patients in language perception. Furthermore, how can music perception be evaluated beyond self-report rating, in order to obtain measurable data? To address this question, estimation of the frontal electroencephalographic (EEG) alpha activity imbalance, acquired through a 19-channel EEG cap, appears to be a suitable instrument to measure the approach/withdrawal (AW index) reaction to external stimuli. Specifically, a greater value of AW indicates an increased propensity to stimulus approach, and vice versa a lower one a tendency to withdraw from the stimulus. Read More

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Non invasive mechanical ventilation in DM1: The strong correlation between lung function, neurological-cognitive function and CTG repeats.

Neuromuscul Disord 2018 Oct 4;28(10):894-895. Epub 2018 Aug 4.

Intensive Care Unit, Hospital Morales Meseguer, Murcia, Spain.

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October 2018
3 Reads

Exercise training in patients with chronic heart failure: A new challenge for Cardiac Rehabilitation Community.

Monaldi Arch Chest Dis 2018 Sep 6;88(3):987. Epub 2018 Sep 6.

Federico II University of Naples, Department of Translational Medical Sciences.

Exercise training (ET) is strongly recommended in patients with chronic stable heart failure (HF). Moderate-intensity aerobic continuous ET is the best established training modality in HF patients. In the last decade, however, high-intensity interval exercise training (HIIT) has aroused considerable interest in cardiac rehabilitation community. Read More

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September 2018