The molluscum contagiosum virus death effector domain containing protein MC160 RxDL motifs are not required for its known viral immune evasion functions.
- Michael Beaury,
- Uday Kiran Velagapudi,
- Sarah Weber,
- Cassandra Soto,
- Tanaji T Talele,
- Daniel Brian Nichols
Virus Genes 2017 Apr 20. Epub 2017 Apr 20.
Department of Biological Sciences, Seton Hall University, 400 South Orange Ave., South Orange, NJ, 07039, USA.
The molluscum contagiosum virus (MCV) uses a variety of immune evasion strategies to antagonize host immune responses. Two MCV proteins, MC159 and MC160, contain tandem death effector domains (DEDs). They are reported to inhibit innate immune signaling events such as NF-κB and IRF3 activation, and apoptosis. Read More