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Dermatol Ther 2020 Jul 2:e13949. Epub 2020 Jul 2.

School of Medicine, Department of Dermatology and Venereology, Uşak University, Turkey.

Many areas of life including patterns of dermatological diseases that patient attend to the hospital were tremendously affected by implementing stay-at-home orders during the COVID-19 pandemic. We aimed to identify the dermatologic interest of the public during the COVID-19 pandemic by using Google Trends. The terms "acne", "hair loss", "eczema", "genital warts", "molluscum contagiosum", "botox", "skin cancer", "sunscreen" were analyzed on first April, first May, first June 2020, and the corresponding period of the previous year in Turkey and Italy by using Google Trends. Read More

J Sports Med Phys Fitness 2020 Jun 25. Epub 2020 Jun 25.

Biomedical Sciences Department, University of West Attica, Athens, Greece.

Acta Derm Venereol 2020 Jul 2;100(14):adv00207. Epub 2020 Jul 2.

Department of Dermatology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, IT-20100 Milan, Italy.

Can Fam Physician 2020 Jun;66(6):419-420

I see numerous children with molluscum contagiosum (MC), and my reassurance that these lesions will disappear without treatment falls on deaf ears. Parents and children always want those lesions gone. They are also worried about other children contracting the infection. Read More

J Gen Virol 2020 Jun 8. Epub 2020 Jun 8.

Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XW, UK.

Molluscum contagiosum virus (MCV) is a common cause of benign skin lesions in young children and currently the only endemic human poxvirus. Following the infection of primary keratinocytes in the epidermis, MCV induces the proliferation of infected cells and this results in the production of wart-like growths. Full productive infection is observed only after the infected cells differentiate. Read More

Int J STD AIDS 2020 May 21:956462420920410. Epub 2020 May 21.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

A man in his 20s with a history of unprotected sex with a commercial sex worker three months before presented with a solitary slowly-growing, well-defined, non-tender, oval, verrucous lesion on the mucosal aspect of his prepuce. Dermoscopy revealed a polylobular, pinkish-white, amorphous structure in the centre with a surrounding crown of vessels that did not cross the centre of the lobules, and histopathology showed keratinocytes containing intracytoplasmic faintly granular eosinophilic inclusions and peripherally-pushed nuclei. A diagnosis of agminated genital molluscum contagiosum was reached on the basis of the above findings. Read More

J Cutan Med Surg 2020 May 13:1203475420926984. Epub 2020 May 13.

5620 507266 54473 Division of Dermatology, Department of Medicine, McGill University Health Centre, Montreal General Hospital, QC, Canada.

Dermatol Pract Concept 2020 3;10(2):e2020037. Epub 2020 Apr 3.

Department of Pathology, Faculty of Medicine, Ahi Evran University, Kirsehir, Turkey.

J Dermatolog Treat 2020 Jun 22:1-6. Epub 2020 Jun 22.

Department of Dermatology, The Princess Alexandra Hospital NHS Trust, Harlow, UK.

Although molluscum contagiosum virus (MCV) infection is a common disease widespread among children and young adults, there is no shared opinion on treatment that can be divided into physical, chemical, medical (immunomodulating or anti-viral). According to some authors, MCV is best left to clear by itself. To assess the clearance of MCV lesions in a sample of pediatric patients. Read More

J Fr Ophtalmol 2020 May 21;43(5):455-459. Epub 2020 Apr 21.

Service d'ophtalmologie B, hôpital des spécialités de Rabat, Rabat 10100, Maroc. Electronic address:

Int J Infect Dis 2020 Jun 18;95:153-156. Epub 2020 Apr 18.

Infectious Diseases Post-Graduate Program, Federal University of Espírito Santo (UFES), Vitória, Espírito Santo, Brazil. Electronic address:

Herpes Simplex Virus (HSV) is the leading cause of genital ulcers worldwide. In Human Immunodeficiency Virus (HIV) co-infected individuals, rare hypertrophic pseudo-tumoral forms have been described as simulating squamous cell carcinoma or other viral infections such as those caused by Varicella zoster, Molluscum contagiosum and HPV induced lesions. Here, we report a case of hypertrophic genital herpes in an HIV-infected patient effectively treated with surgery and topical 5% imiquimod after the recurrence of lesions. Read More

Am Fam Physician 2020 Apr;101(7):399-406

Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.

Cryosurgery is the application of freezing temperatures to achieve the destruction of tissue. Cutaneous cryosurgery has become a commonly performed outpatient procedure because of the combination of its safety, effectiveness, low cost, ease of use, lack of need for injectable anesthetic, and good cosmetic results. Cryosurgery may be performed in the outpatient setting using dipstick, spray, or cryoprobe techniques to treat a variety of benign, premalignant, and malignant skin lesions with high cure rates. Read More

Pediatr Dermatol 2020 May 1;37(3):476-479. Epub 2020 Mar 1.

Department of Pediatric Emergency Medicine, Hadassah Medical Center, Jerusalem, Israel.

Background: Molluscum contagiosum (MC) is a common skin infection in the pediatric age group. The infection is self-limited and manifests as discrete, umbilicated skin-colored papules on any skin surface of the body. At times, complications such as local dermatitis and swelling, erythema, and pus formation may appear. Read More

Ocul Immunol Inflamm 2020 Feb 14:1-9. Epub 2020 Feb 14.

Division of Ophthalmology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Both infective and neoplastic eyelid and orbital conditions in human immunodeficiency virus (HIV) infected patients are often the result of opportunistic or co-infections (OI). In most cases, these clinical findings in younger patients alert the physician to suspected underlying HIV infection. When the eyelids and periorbital skin are primarily involved in OI with varicella-zoster virus it is called Herpes Zoster Ophthalmicus. Read More

Dermatitis 2020 Mar/Apr;31(2):157-164

Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine.

Background: Atopic dermatitis (AD) is associated with altered skin barrier, microbiome, and immune dysregulation that may increase risk of skin infections.

Objective: The aim of the study was to determine whether AD is associated with skin infections and related outcomes.

Methods: Data from the 2006 to 2012 National Emergency Department Sample were analyzed, including an approximately 20% sample of all US emergency department (ED) visits (N = 198,102,435 adults or children). Read More

Dermatol Online J 2019 Nov 15;25(11). Epub 2019 Nov 15.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA.

CD30+ T cell pseudolymphomas (CD30+ PSL) are a group of benign inflammatory cutaneous disorders that can develop in settings of viral infections or drug reactions. Owing to their histological similarities to malignant lymphomas, these benign infiltrates are occasionally misdiagnosed as malignant, causing significant concerns for patients and physicians. Herein, we report a patient with CD30+ PSL associated with molluscum contagiosum whose initial biopsy revealed atypical large CD30-expressing cells, leading to a misdiagnosis of primary cutaneous anaplastic large cell lymphoma and referral to our cutaneous lymphoma clinic. Read More

Pediatr Dermatol 2020 Mar 6;37(2):379-380. Epub 2020 Feb 6.

Division of Dermatology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

Pemphigus and pemphigus-like reactions can be triggered by a variety of medications including topical therapies, such as imiquimod. While the association between imiquimod and pemphigus-like reactions has been reported in adults, this is the first report of a generalized reaction beyond the site of imiquimod application in a child. The mechanism by which this occurs may be through a unique pathway, separate from the classic antibody-mediated pathway. Read More

Skin Appendage Disord 2020 Jan 29;6(1):55-57. Epub 2019 Oct 29.

Department of Pathology, Ahi Evran University, Kırşehir, Turkey.

Molluscum contagiosum (MC) is a self-limiting viral infectious cutaneous disease usually characterized by pinkish skin color and round umbilicated papules varying in size and shape. MC can affect any region, but the lower abdomen, thighs, genitals, and perianal area are the sites most commonly involved. Atypical localizations of the lesions may be difficult to diagnose. Read More

FP Essent 2020 Feb;489:16-20

Maine-Dartmouth Family Medicine Residency, 15 East Chestnut St, Augusta, ME 04330.

Fungal and viral skin infections are common and typically are managed by family physicians. The fungal skin infections commonly seen in family practice include the various forms of tinea: tinea corporis, tinea gladiatorum, tinea cruris, tinea pedis, tinea capitis, and tinea unguium (eg, onychomycosis). Common viral skin infections include herpes simplex virus infection, herpes zoster, cutaneous and genital warts, and molluscum contagiosum. Read More

J Dtsch Dermatol Ges 2020 Jan 17;18(1):44-46. Epub 2020 Jan 17.

Department of Dermatology, National Medical Center, Seoul, Korea.

Eur J Microbiol Immunol (Bp) 2019 Dec 25;9(4):138-143. Epub 2019 Nov 25.

Department of Microbiology and Hospital Hygiene, Bundeswehr Hospital Hamburg, Hamburg, Germany.

Introduction: The study was performed to estimate the prevalence and determinants of occurrence of sexually transmitted infections (STIs) in paratroopers and navy soldiers by anonymously analyzing medical records from the medical departments of two large German barracks in order to assess the need for medical STI prevention.

Methods: Medical records from 80 paratroopers and 80 navy soldiers were screened for records of STI. Results were anonymously collected next to information on risk factors, as well as diagnostic and therapeutic management, and comparatively assessed. Read More

Harefuah 2020 Jan;159(1):14-17

Department of Dermatology, Beilinson Hospital, Rabin Medical Center, Petach Tikva, Israel.

Introduction: Cryptococcus neoformans is an opportunistic fungus which causes severe morbidity and mortality among immune-compromised patients. Cutaneous manifestations of systemic cryptococcosis are rare and may include a papulo-nodular rash, ulcers, cellulitis, molluscum contagiosum-like papules and more. The Tzanck smear is a well-known simple diagnostic test which can be performed bedside, in order to characterize cell cytology. Read More

J Gen Virol 2020 Jan 10. Epub 2020 Jan 10.

Bundeswehr Institute of Microbiology, Munich, Germany.

Cases of pox-like lesions in horses and donkeys have been associated with poxviruses belonging to different genera of the family . These include the orthopoxviruses vaccinia virus (VACV), horsepoxvirus (HPXV) and cowpoxvirus (CPXV), as well as a potentially novel parapoxvirus and molluscum contagiosum virus (MOCV). However, with the exception of VACV, HPXV and CPXV, the genomic characterization of the causative agents remains largely elusive with only single short genome fragments available. Read More

JAAD Case Rep 2020 Jan 20;6(1):13-15. Epub 2019 Dec 20.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

Cutis 2019 Nov;104(5):301-305;E1;E2

Departments of Dermatology and Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Molluscum contagiosum virus (MCV) is a poxvirus that causes infection in humans that is limited to the cutis and subcutaneous levels of the skin. The virus is transmitted from close associates in settings such as pools, day care, and bathtubs. Pediatric molluscum is common in school-aged children and resolves spontaneously in healthy children. Read More

J Clin Immunol 2020 Feb 21;40(2):299-309. Epub 2019 Dec 21.

Department of Laboratory Immunology, PathWest QEII Medical Centre, Perth, WA, Australia.

Variants in MAGT1 have been identified as the cause of an immune deficiency termed X-linked immunodeficiency with magnesium defect, Epstein-Barr virus (EBV) infection and neoplasia (XMEN) disease. Here, we describe 2 cases of XMEN disease due to novel mutations in MAGT1, one of whom presented with classical features of XMEN disease and another who presented with a novel phenotype including probable CNS vasculitis, HHV-8 negative multicentric Castelman disease and severe molluscum contagiosum, thus highlighting the clinical diversity that may be seen in this condition. Peripheral blood immunophenotyping of these 2 patients, together with an additional 4 XMEN patients, revealed reduced NKG2D expression, impaired CD28 expression on CD8 T cells, CD4 T cell lymphopenia, an inverted CD4:CD8 ratio and decreased memory B cells. Read More

Immunobiology 2020 Mar 27;225(2):151877. Epub 2019 Nov 27.

Department of Pediatrics, Division of Hematology/Oncology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. Electronic address:

Background: Recurrent or refractory infections can be a warning sign of primary immunodeficiency diseases (PID). Such mimicking PID (mPID) can occur in patients with Langerhans cell histiocytosis (LCH). Because some cases with refractory molluscum contagiosum-like lesions and persistent otorrhea are finally diagnosed with LCH, we wondered whether such mPID can occur in LCH children and affect on their prognosis. Read More

Transpl Infect Dis 2020 Feb 1;22(1):e13235. Epub 2020 Jan 1.

Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea.

Indian Dermatol Online J 2019 Nov-Dec;10(6):755-756. Epub 2019 Nov 1.

Department of Pathology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.

BMC Infect Dis 2019 Nov 27;19(1):1003. Epub 2019 Nov 27.

Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, China.

Background: Although antiretroviral therapy (ART) has greatly improved the prognosis of acquired immunodeficiency syndrome (AIDS) patients globally, opportunistic infections (OIs) are still common in Chinese AIDS patients, especially cryptococcosis.

Case Presentation: We described here two Chinese AIDS patients with cryptococcal infections. Case one was a fifty-year-old male. Read More

Cutis 2019 Oct;104(4):E18-E20

Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, USA.

Arch Soc Esp Oftalmol 2020 Mar 16;95(3):e18. Epub 2019 Nov 16.

Servicio de Oftalmología, Quirónsalud Hospital Costa Adeje, Adeje, Santa Cruz de Tenerife, España.

Obstet Gynecol Int 2019 16;2019:1830245. Epub 2019 Oct 16.

Dermatology Clinic, University of Catania, Catania, Italy.

Background: Gynecology and dermatology share the diagnosis and the management of some disorders of the female external genital area. In the last decade, clinical diagnosis in dermatology has dramatically improved, thanks to the introduction of dermatoscopy.

Technique: Dermatoscopy is a noninvasive, rapid, and simple technique performed with an affordable handheld instrument called dermatoscope, endowed with a light source and a high-quality lens achieving 10 times magnification. Read More

BMJ 2019 Nov 14;367:l6013. Epub 2019 Nov 14.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China

J Mycol Med 2020 Apr 16;30(1):100904. Epub 2019 Oct 16.

Infectious Diseases Department of Hospital do Mal de Hansen, Cumura, Guine Bissau.

African histoplasmosis is the relatively unknown infection by Histoplasma capsulatum var. duboisii. It is endemic to Central and West Africa, generally involving the skin with potential for systemic dissemination, and has been described mainly in immunocompetent hosts. Read More

An Pediatr (Barc) 2019 Oct 18. Epub 2019 Oct 18.

Servicio de Dermatología, Hospital Clínico Universitario de Valencia, Universidad de Valencia, Valencia, España.

Pediatr Dermatol 2020 Jan 18;37(1):224-225. Epub 2019 Oct 18.

Department of Clinical, Surgical, Diagnostics and Pediatric Sciences, Institute of Dermatology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy.

Molluscum contagiosum is a common childhood condition, and although it is self-limited, treatments are often prescribed. Several medications are available, but there is no consensus regarding the optimal choice in the pediatric population. We report a child who underwent potassium hydroxide 5% treatment resulting in superficial diffuse erosions caused by the inappropriate application. Read More

Case Rep Dermatol 2019 Sep-Dec;11(3):260-263. Epub 2019 Sep 30.

Service de Dermatologie, CHU de Martinique, Fort de France, France.

Lymphangioma circumscriptum (LC) is a vascular malformation resulting from a developmental anomaly of the superficial lymphatic system of the skin. It is benign albeit uncommon. LC less frequently occurs on the penis. Read More

J Am Acad Dermatol 2020 Apr 3;82(4):887-894. Epub 2019 Oct 3.

Novan, Inc, Morrisville, North Carolina. Electronic address:

Background: Although a variety of ablative, topical, and systemic therapies are used for molluscum contagiosum (MC), none has been well studied or approved by the US Food and Drug Administration.

Objectives: To compare the efficacy and tolerability of topical SB206 (berdazimer sodium gel coadministered with hydrogel) with vehicle.

Methods: A 12-week, phase 2, multicenter, randomized, double-blind, vehicle-controlled clinical trial of topical SB206. Read More

Dermatol Ther 2019 11 9;32(6):e13088. Epub 2019 Oct 9.

Skin Institute & School of Dermatology (SISD), New Delhi, India.

Molluscum contagiosum (MC) is a benign viral infection, which may have florid manifestations in immunosuppressed patients. Moreover, the treatment is often unsatisfactory in these patients and it maybe recalcitrant. We hereby report the use of intralesional vitamin D immunotherapy in two immunosuppressed patients with persistent widespread MC lesions. Read More

J Int Med Res 2019 Sep 19:300060519873490. Epub 2019 Sep 19.

Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Objectives: Dermatological disorders are common in general pediatric practice. This study aimed to examine common skin problems and the manner in which they tend to be misdiagnosed.

Methods: A cross-sectional study was conducted from January 2015 to December 2016 using medical record data from the Pediatric Dermatological Outpatient Unit at Khon Kaen University, Faculty of Medicine. Read More

Clin Colon Rectal Surg 2019 Sep 6;32(5):340-346. Epub 2019 Sep 6.

Medical University of South Carolina, Charleston, South Carolina.

This article reviews the epidemiology, diagnosis, and management of common viral infections of the perianal skin and anorectum including herpes simplex virus, human immune deficiency virus, and molluscum contagiosum. Human papilloma virus infection is reviewed in the subsequent article. Read More

Acta Virol 2019 ;63(3):333-337

Molluscum contagiosum is a common, self-limiting infectious disease of the skin caused by molluscum contagiosum virus (MCV). The disease primarily affects children, sexually active adults, and immunocompromised individuals. Transmission of the virus occurs by direct skin contact. Read More

J Am Acad Dermatol 2020 01 6;82(1):254-255. Epub 2019 Sep 6.

Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea; Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea; Research Institute for Convergence of Biomedical Science and Technology, Yangsan, Korea. Electronic address:

Nutrients 2019 Sep 4;11(9). Epub 2019 Sep 4.

CIRI, Centre International de Recherche en Infectiologie, CIRI, 69007 Lyon, France.

Reactive oxygen species (ROS) are frequently produced during viral infections. Generation of these ROS can be both beneficial and detrimental for many cellular functions. When overwhelming the antioxidant defense system, the excess of ROS induces oxidative stress. Read More

J Dermatolog Treat 2019 Aug 29:1-5. Epub 2019 Aug 29.

Dermatology, Venereology and Andrology and Departments, Faculty of Medicine, Zagazig University , Zagazig , Egypt.

The immune system plays an important part in the clearance of molluscum contagiosum (MC) and, therefore, there has lately been a trend in using immunotherapy in MC therapy. Tuberculin-purified protein derivatives (PPDs) and topical cantharidin have not earlier been compared with their effectiveness in therapy The aim of this research was to determine the effectiveness and security of intralesional immunotherapy in the therapy of MC with tuberculin PPD versus topical cantharidin Twenty patients with various MC lesions received topical cantharidin as control (group A) and 20 MC patients received intralesional tuberculin PPD following prior intradermal immunity tests (group B‏). Complete clearance of lesions was detected in 90. Read More

Clin Case Rep 2019 Jul 16;7(7):1273-1275. Epub 2019 May 16.

Department of Dermatology The Third Affiliated Hospital of Suzhou University Changzhou China.

In 50-year-old female patients, the purple-red papules in the right upper arm were misdiagnosed as molluscum contagiosum or scars. The diagnosis of angiolymphoid hyperplasia with eosinophilia was determined on the basis of the clinicopathological features. Read More

Ophthalmologe 2020 Jan;117(1):73-77

Zentrum für Augenheilkunde, Universität zu Köln, Medizinische Fakultät und Uniklinik Köln, Kerpener Str. 62, 50924, Köln, Deutschland.

Background: A space-occupying lesion of the eyelid in young adults is often a sign of an inflammation, a trauma or a benign neoplasm. The aim of this case report is to demonstrate a rare basal cell carcinoma, which presumably already arose in adolescence without further high-risk factors.

Methods: A 28-year-old male patient presented for a second opinion on a painless swelling of the right lower eyelid. Read More

Front Pediatr 2019 10;7:293. Epub 2019 Jul 10.

Molecular Identification and Diagnosis Unit, Laboratory of Biotechnology, Center for Biosciences and Biotechnology, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Brazil.

In human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) patients with very low CD4 cell counts, there is a temporal relationship between administration of antiretroviral therapy (ART) and an increased inflammatory response state known as the immune reconstitution inflammatory syndrome (IRIS). The predominant clinical presentation of IRIS is an infectious disease that can be life-threatening. IRIS-related infectious events are distributed similarly between adult males and females, albeit a few studies have shown a skewing toward the male sex in pediatric IRIS. Read More