Diagn Cytopathol 2018 May 7. Epub 2018 May 7.

Department of Dermatology, Lady Hardinge Medical College, Delhi, India.

Molluscum contagiosum (MC) is most frequently a self-limiting benign viral skin disease. Transmitted by direct skin contact, it is characterized by flesh-colored, dome-shaped, umbilicated lesions. Diagnosis of MC is often done clinically, but when needed, biopsy can be performed, in which characteristic Henderson-Patterson bodies, representing intracytoplasmic assemblies of the virus, are pathognomonic. Read More

J Dermatol 2018 Apr 18. Epub 2018 Apr 18.

Department of Dermatology, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan.

An Pediatr (Barc) 2018 Apr 13. Epub 2018 Apr 13.

Pediatría, Centro de Salud de San Sadurniño, SERGAS, San Sadurniño, A Coruña, España.

Front Immunol 2018 23;9:237. Epub 2018 Feb 23.

Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

The phosphatidylinositol-3-kinase (PI3K)/Akt pathway is important for multiple stages of herpesvirus replication including virus entry, replication, latency, and reactivation. Recently, patients with gain-of-function mutations in the p110δ-catalytic subunit of PI3K or in the p85-regulatory subunit of PI3K have been reported. These patients have constitutively active PI3K with hyperactivation of Akt. Read More

G Ital Dermatol Venereol 2018 Mar 26. Epub 2018 Mar 26.

Department of Dermatology, University of Rome "Tor Vergata", Rome, Italy.

Actas Dermosifiliogr 2018 Mar 22. Epub 2018 Mar 22.

Servicio de Dermatología, Hospital Infantil del Niño Jesús, Madrid, España. Electronic address:

Molluscum contagiosum is one of the most common viral infections in childhood. It is a benign and usually self-limiting infection, but its treatment in children can be challenging, particularly when the patient presents multiple lesions or when lesions are symptomatic or highly visible. Several treatment options exist. Read More

Pediatr Dermatol 2018 May 25;35(3):418-419. Epub 2018 Mar 25.

Department of Pediatrics, Sainte-Justine Hospital, Montreal, QC, Canada.

Molluscum contagiosum is a common contagious disease in children characterized by small skin-colored umbilicated papules. Although spontaneous resolution is common, many parents and patients seek treatment. Multiple therapeutic modalities have been described. Read More

Pediatr Dermatol 2018 Mar;35(2):280-281

Dermatology Service, Hospital Ramos Mejía, Buenos Aires, Argentina.

Pediatr Dermatol 2018 Mar;35(2):282-283

Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, VU University Medical Center Amsterdam, Amsterdam, The Netherlands.

Int J Dermatol 2018 Mar 24. Epub 2018 Mar 24.

Luanda Medical Center, Luanda, Angola.

Background: Prevalence of skin diseases in Luanda (Angola) is unknown, and publications are barely found in the literature. We aim to describe, for the first time, the frequency of skin disease spectrum in phototype V-VI Angolan population in Luanda City.

Methods: We included Fitzpatrick phototype V-VI Angolan patients who consulted the Dermatology Unit in Luanda Medical Center during a 1-year period. Read More

Cutis 2018 Feb;101(2):136-140

Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

Molluscum contagiosum (MC) is a common, self-limited cutaneous infection in immunocompetent individuals. However, in immunocompromised individuals the infection often has an atypical presentation and can be difficult to eradicate, making both the diagnosis and treatment challenging. Due to advancements in the management of patients with human immunodeficiency virus (HIV) and cancer, there is a growing population of immunosuppressed individuals, signaling the need for dermatologists to recognize and manage related skin diseases. Read More

Pediatr Blood Cancer 2018 Mar 12. Epub 2018 Mar 12.

Department of Dermatology, Hospital Universitari Arnau de Vilanova, Lleida, Spain.

Langerhans cell histiocytosis (LCH) is a disorder characterized by accumulation of Langerhans-like cells in one or various organs. A correct staging work-up is essential since there are multiorgan presentations with a poor prognosis. We report three patients with LCH skin lesions mimicking molluscum contagiosum in association with both high and low risk organ involvement. Read More

Pediatr Dermatol 2018 May 26;35(3):336-342. Epub 2018 Feb 26.

Institut Universitari d'Investigació en Atenció Primària Jordi Gol, Barcelona, Spain.

Background/objectives: Molluscum contagiosum is the most common skin infection in children. One topical treatment used for Molluscum contagiosum is potassium hydroxide. The objective of this study was to compare the efficacy of potassium hydroxide topical treatment at different concentrations with that of placebo in terms of complete clearing of Molluscum contagiosum lesions and to assess the safety and tolerance of potassium hydroxide topical treatment. Read More

Paediatr Child Health 2017 Aug 30;22(5):241-242. Epub 2017 Jun 30.

Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

J Gen Virol 2018 Feb;99(2):246-252

1​Department of Microbiology, University of Illinois, Urbana, IL 61801, USA.

Molluscum contagiosum virus (MCV) causes persistent, benign skin neoplasm in children and adults. MCV is refractive to growth in standard tissue culture and there is no relevant animal model of infection. Here we investigated whether another poxvirus (vaccinia virus; VACV) could be used to examine MCV immunoevasion protein properties in vivo. Read More

Acta Paediatr 2018 Jan 24. Epub 2018 Jan 24.

Division of Pediatrics, Department of Health Sciences, IRCAD (Interdisciplinary Research Center of Autoimmune Diseases), University of Piemonte Orientale Amedeo Avogadro, Novara, Italy.

Aim: This study evaluated the prevalence of infectious diseases and immunisation status of children adopted from Africa.

Methods: We studied 762 African children referred to 11 Italian paediatric centres in 2009-2015. Clinical and laboratory data were retrospectively collected and analysed. Read More

J Clin Aesthet Dermatol 2017 Oct 1;10(10):34-39. Epub 2017 Oct 1.

Dr. Moy is from Facial Cosmetic Surgery in Beverly Hills, California.

Many skin conditions and diseases are characterized by inflammation, infection, and hyperplasia. Safe and effective topical treatment options that can be used long-term are needed. Traditional botanical medicines, which are often complex mixtures that exert their biological activities via multiple mechanisms of action, are being studied as potential new active ingredients in dermatology. Read More

Br J Dermatol 2018 Jan 12. Epub 2018 Jan 12.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

The Hippo signaling pathway, which is highly conserved in organisms ranging from Drosophila to mammals, plays a key role in organ size control, cellular proliferation, survival and tumorigenesis Yes-associated protein (YAP) is the major downstream effector of Hippo signaling pathway and transcriptional co-activator with PDZ-binding motif (TAZ) is a YAP paralog. Recently, Zhang et al. found that YAP/TAZ acts as natural inhibitors of TANK binding kinase 1 (TBK1), which is a key component for cytosolic nucleic acid sensing antiviral defense and antiviral physiology This article is protected by copyright. Read More

Am J Dermatopathol 2018 Jan 11. Epub 2018 Jan 11.

Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH Geisel School of Medicine at Dartmouth, Hanover, NH.

G Ital Dermatol Venereol 2018 02;153(1):127-128

Division of Dermatology, Department of Specialized, Clinical and Experimental Medicine, University of Bologna, Bologna, Italy.

JAMA Dermatol 2018 Feb;154(2):203-204

Department of Dermatology, Kaiser Permanente, San Francisco, California.

Clinical Question: How effective and safe are treatments for nongenital molluscum contagiosum in persons without immune deficiency?

Bottom Line: Compared with placebo, imiquimod, 5%, cream was not more effective in clearing molluscum contagiosum and caused more local adverse effects, including application site reactions, in children aged 2 to 12 years; because high-quality evidence for other interventions is lacking, allowing for natural resolution of the infection remains a reasonable approach. Read More

Indian J Dermatol Venereol Leprol 2018 Jan-Feb;84(1):76-78

Department of DVL, Dr SN Medical College, Jodhpur, Rajasthan, India.

J Am Acad Dermatol 2018 Jan;78(1):198-200

Department of Dermatology, Henry Ford Health System, Detroit, Michigan.

Indian Dermatol Online J 2017 Nov-Dec;8(6):391-405

Allergy Immunology Unit, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Primary immunodeficiency disorders (PIDs) are a group of disorders affecting the capability to fight against infection. These include defects in T cells and B cells affecting cell-mediated and humoral immunity, respectively, combined humoral and cell-mediated immunodeficiency, defects in phagocytosis, complement defects, and defects in cytokine or cytokine signalling pathways which are detrimental for immune function. Depending upon the type and severity, age at onset of symptoms can vary from neonatal period to late childhood. Read More

N Engl J Med 2017 Nov;377(21):e30

Saints Cyril and Methodius University, Skopje, Macedonia

Pediatr Dermatol 2018 Jan 22;35(1):e55-e56. Epub 2017 Nov 22.

Department of Dermatology, Hospital Universitario Fundacion Jiménez Diaz, Universidad Autónoma, Madrid, Spain.

Juvenile xanthogranuloma is the most common form of non-Langerhans cell histiocytosis in childhood. The clinical differential diagnosis of a solitary juvenile xanthogranuloma includes molluscum contagiosum, Spitz nevus, and melanoma. Lesions larger than 2 cm in diameter may be misdiagnosed as hemangiomas, but this is not typical of smaller juvenile xanthogranuloma. Read More

J Pediatr Adolesc Gynecol 2018 Apr 21;31(2):156-157. Epub 2017 Nov 21.

Department of Obstetrics and Gynecology, Division of Pediatric and Adolescent Gynecology, UT Southwestern Medical Center, Children's Health, Dallas, Texas.

Background: Mastocytosis is a rare benign disorder characterized by the finding of mast cells in the skin and other organs, occurring in adult as well as pediatric age groups. The cutaneous form is the most common presentation in childhood and is rarely located on the vulva.

Case: A 9-year-old prepubertal girl presented with bilateral vulvar nodules found incidentally by her pediatrician. Read More

Ned Tijdschr Geneeskd 2017 ;161(0):D1850

Huisartsenpraktijk Vondelplein, Amersfoort.

A healthy 1-year old girl visits her general practitioner with a solitary dome-shaped tumour on her thorax. The lesion is about one cm in diameter and is present since several months. Pathological research reveals a solitary giant molluscum contagiosum. Read More

Curr Protoc Microbiol 2017 Nov 9;47:14A.6.1-14A.6.9. Epub 2017 Nov 9.

Department of Microbiology, Cardiff University School of Medicine, Cardiff, United Kingdom.

Molluscum contagiosum virus (MCV) is a common skin pathogen of children and young adults. Infection with MCV causes benign skin tumors in children and young adults and is mostly self-limiting. In contrast to orthopoxviruses, MCV infections tend to take a subacute clinical course but may persist for up to 12 months. Read More

J Dermatolog Treat 2017 Nov 22:1-3. Epub 2017 Nov 22.

a Department of Pediatrics , Nationwide Children's Hospital , Columbus , OH , USA.

Objectives: To evaluate the safety and efficacy of an East Indian sandalwood oil (EISO) product as a topical treatment for molluscum contagiosum.

Materials And Methods: Ten subjects ranging in age from 22 months to 29 years were recruited. Subjects were instructed to apply an EISO product to the lesions twice daily. Read More

Clin Exp Dermatol 2018 Jan 23;43(1):66-67. Epub 2017 Oct 23.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Cà Granda Ospedale Maggiore Policlinico, 20122, Milan, Italy.

Int J STD AIDS 2017 11;28(13):1360

Dermatology and Venereology Private Practice, Bari and Barletta, Italy.

J Dermatol 2018 Feb 3;45(2):e49-e50. Epub 2017 Oct 3.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Clin Exp Dermatol 2017 Dec 22;42(8):923-925. Epub 2017 Sep 22.

Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, 93 Jungbu-daero, Paldal-gu, Suwon, 16247, Korea.

Bioessays 2017 Oct 8;39(10). Epub 2017 Sep 8.

School of Systems Biology, George Mason University, Fairfax, VA, USA.

Intracellular bacteria were recently shown to employ eukaryotic prenylation system for modifying activity and ensuring proper intracellular localization of their own proteins. Following the same logic, the proteins of viruses may also serve as prenylation substrates. Using extensively validated high-confidence prenylation predictions by PrePS with a cut-off for experimentally confirmed farnesylation of hepatitis delta virus antigen, we compiled in silico evidence for several new prenylation candidates, including IRL9 (CMV) and few other proteins encoded by Herpesviridae, Nef (HIV-1), E1A (human adenovirus 1), NS5A (HCV), PB2 (influenza), HN (human parainfluenza virus 3), L83L (African swine fever), MC155R (molluscum contagiosum virus), other Poxviridae proteins, and some bacteriophages of human associated bacteria. Read More

Pediatr Dermatol 2017 Sep;34(5):504-515

Dermatological Surgery and Laser Unit, St John's Institute of Dermatology, Guy's Hospital Cancer Centre, Guy's & St Thomas' NHS Foundation Trust, London, UK.

Molluscum contagiosum (MC) is an infectious dermatosis that commonly presents in children and immunocompromised individuals. Although lesions usually resolve spontaneously after several months, they can be symptomatic and cause psychosocial distress. We review the evidence underlying treatment methods available for MC lesions, including potassium hydroxide, salicylic acid, hydrogen peroxide, retinoids, cantharidin, cryotherapy, curettage, and pulsed dye laser to aid practicing dermatologists in therapy selection. Read More

Acta Dermatovenerol Croat 2017 Jul;25(2):164-166

Efstathia Pasmatzi, MD, Department of Dermatology School of Medicine University of Patras, 26504 Rio-Patras, Greece;

Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usually occurs in young children, sexually active adults, and immunocompromised individuals. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or multiple papules, measuring 2-6 mm in diameter with a central umbilication that occur on the skin and the mucous membranes. Read More

Ann Allergy Asthma Immunol 2017 11 31;119(5):446-451. Epub 2017 Aug 31.

Department of Pediatrics, Unit of Pediatric Genetics and Immunology, University of Messina, Messina, Italy.

Background: Although mutations in the filaggrin (FLG) gene have been reported to predispose patients with atopic dermatitis (AD) skin infection susceptibility, to date, the data reported in the literature are still controversial.

Objective: To evaluate the role of FLG polymorphisms expression and risk of developing a concomitant Molluscum contagiosum sustained skin infection in the pediatric population with AD.

Methods: A total of 100 children with AD and 97 healthy children were enrolled. Read More

Turk J Ophthalmol 2017 Aug 15;47(4):226-230. Epub 2017 Aug 15.

Selçuk University Faculty of Medicine, Department of Ophthalmology, Konya, Turkey.

Molluscum contagiosum (MC) is a viral infection of the skin and mucosal tissues characterized by skin-colored or transparent round nodules with a dimple or pit in the center. The infection is caused by a DNA poxvirus called the MC virus. Although MC generally occurs in children, it has also been reported in immunocompromised and atopic patients. Read More

Iran Biomed J 2018 03 15;22(2):129-33. Epub 2017 Aug 15.

Research and Development (R&D) Department, Keyvan Virology Specialty Laboratory (KVSL), Tehran, Iran.

Background: The present study is the first comprehensive report of the Molluscum contagiosum virus (MCV) in Iran based on the molecular technique for differentiation and typing of the MCV1 and MCV2.

Methods: Patients were diagnosed as having tumor-like genital warts less than 5 mm in diameter, and HIV seronegative samples were chosen for this cross-sectional study. TaqMan real-time PCR was used to identify MCV following clinical examination. Read More

Int J Surg Pathol 2018 Apr 14;26(2):151-152. Epub 2017 Aug 14.

1 Ghent University and Ghent University Hospital, Ghent, Belgium.

Viruses 2017 08 8;9(8). Epub 2017 Aug 8.

Department of Biological Sciences, Seton Hall University, South Orange, NJ 07039, USA.

Cells have multiple means to induce apoptosis in response to viral infection. Poxviruses must prevent activation of cellular apoptosis to ensure successful replication. These viruses devote a substantial portion of their genome to immune evasion. Read More

Drug Ther Bull 2017 Aug 2. Epub 2017 Aug 2.

▼ Strontium ranelate discontinued ● Limited treatment options for molluscum contagiosum ● Finasteride drug safety alert ● Does doxycycline delay the next COPD exacerbation? ● Support for WHO standards on reporting clinical trial results ● Delayed antibiotic prescription for lower respiratory tract infections ● Nystatin dose change - much ado about nothing? Read More

Drug Ther Bull 2017 Aug 2. Epub 2017 Aug 2.

Pediatr Dermatol 2017 Sep 21;34(5):e288-e289. Epub 2017 Jul 21.

Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.

Langerhans cell histiocytosis (LCH) is a rare disorder characterized by clonal proliferation of Langerhans cells in the skin. A molluscum-like presentation of cutaneous LCH is rare but important to consider for examination and management. We present an atypical molluscum-like LCH case and review the literature for common features of this unusual presentation. Read More

Virus Genes 2017 Dec 6;53(6):856-867. Epub 2017 Jul 6.

Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.

The genome of Eptesipoxvirus (EPTV) is the first poxvirus genome isolated from a microbat. The 176,688 nt sequence, which is believed to encompass the complete coding region of the virus, is 67% A+T and is predicted to encode 191 genes. 11 of these genes have no counterpart in GenBank and are therefore unique to EPTV. Read More

J Eur Acad Dermatol Venereol 2017 Nov 3;31(11):e504-e505. Epub 2017 Jul 3.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.

Curr Urol Rep 2017 Aug;18(8):62

Virginia Mason Medical Center, Seattle, WA, USA.

Purpose Of Review: Genital dermatology represents a challenge to many providers. Though dermatologic lesions involving the genitalia may present to any of a number of practices, ranging from primary care to urology, gynecology, and dermatology, few training programs provide significant training regarding the diagnosis and management of genital dermatologic lesions. The purpose of this review is to provide urologists with an overview of common genital dermatological lesions that may be encountered in a clinic. Read More