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    ELISA for Molluscum Contagiosum Virus.
    Curr Protoc Microbiol 2017 Nov 9;47:14A.6.1-14A.6.9. Epub 2017 Nov 9.
    Department of Microbiology, Cardiff University School of Medicine, Cardiff, United Kingdom.
    Molluscum contagiosum virus (MCV) is a common skin pathogen of children and young adults. Infection with MCV causes benign skin tumors in children and young adults and is mostly self-limiting. In contrast to orthopoxviruses, MCV infections tend to take a subacute clinical course but may persist for up to 12 months. Read More

    Treatment of molluscum contagiosum with an East Indian Sandalwood Oil product.
    J Dermatolog Treat 2017 Nov 6:1-12. Epub 2017 Nov 6.
    a Department of Pediatrics , Nationwide Children's Hospital , Columbus , OH.
    Objectives: To evaluate the safety and efficacy of an East Indian Sandalwood Oil (EISO) product as a topical treatment for molluscum contagiosum.

    Materials And Methods: Ten subjects ranging in age from 22 months to 29 years were recruited. Subjects were instructed to apply an EISO product to the lesions twice daily. Read More

    Prenylation of viral proteins by enzymes of the host: Virus-driven rationale for therapy with statins and FT/GGT1 inhibitors.
    Bioessays 2017 Oct 8;39(10). Epub 2017 Sep 8.
    School of Systems Biology, George Mason University, Fairfax, VA, USA.
    Intracellular bacteria were recently shown to employ eukaryotic prenylation system for modifying activity and ensuring proper intracellular localization of their own proteins. Following the same logic, the proteins of viruses may also serve as prenylation substrates. Using extensively validated high-confidence prenylation predictions by PrePS with a cut-off for experimentally confirmed farnesylation of hepatitis delta virus antigen, we compiled in silico evidence for several new prenylation candidates, including IRL9 (CMV) and few other proteins encoded by Herpesviridae, Nef (HIV-1), E1A (human adenovirus 1), NS5A (HCV), PB2 (influenza), HN (human parainfluenza virus 3), L83L (African swine fever), MC155R (molluscum contagiosum virus), other Poxviridae proteins, and some bacteriophages of human associated bacteria. Read More

    Molluscum Contagiosum: Review and Update on Management.
    Pediatr Dermatol 2017 Sep;34(5):504-515
    Dermatological Surgery and Laser Unit, St John's Institute of Dermatology, Guy's Hospital Cancer Centre, Guy's & St Thomas' NHS Foundation Trust, London, UK.
    Molluscum contagiosum (MC) is an infectious dermatosis that commonly presents in children and immunocompromised individuals. Although lesions usually resolve spontaneously after several months, they can be symptomatic and cause psychosocial distress. We review the evidence underlying treatment methods available for MC lesions, including potassium hydroxide, salicylic acid, hydrogen peroxide, retinoids, cantharidin, cryotherapy, curettage, and pulsed dye laser to aid practicing dermatologists in therapy selection. Read More

    Topical Imiquimod is an Effective and Safe Drug for Molluscum Contagiosum in Children.
    Acta Dermatovenerol Croat 2017 Jul;25(2):164-166
    Efstathia Pasmatzi, MD, Department of Dermatology School of Medicine University of Patras, 26504 Rio-Patras, Greece;
    Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usually occurs in young children, sexually active adults, and immunocompromised individuals. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or multiple papules, measuring 2-6 mm in diameter with a central umbilication that occur on the skin and the mucous membranes. Read More

    Filaggrin mutations and Molluscum contagiosum skin infection in patients with atopic dermatitis.
    Ann Allergy Asthma Immunol 2017 Aug 30. Epub 2017 Aug 30.
    Department of Pediatrics, Unit of Pediatric Genetics and Immunology, University of Messina, Messina, Italy.
    Background: Although mutations in the filaggrin (FLG) gene have been reported to predispose patients with atopic dermatitis (AD) skin infection susceptibility, to date, the data reported in the literature are still controversial.

    Objective: To evaluate the role of FLG polymorphisms expression and risk of developing a concomitant Molluscum contagiosum sustained skin infection in the pediatric population with AD.

    Methods: A total of 100 children with AD and 97 healthy children were enrolled. Read More

    Eyelid Molluscum Contagiosum Lesions in Two Patients with Unilateral Chronic Conjunctivitis.
    Turk J Ophthalmol 2017 Aug 15;47(4):226-230. Epub 2017 Aug 15.
    Selçuk University Faculty of Medicine, Department of Ophthalmology, Konya, Turkey.
    Molluscum contagiosum (MC) is a viral infection of the skin and mucosal tissues characterized by skin-colored or transparent round nodules with a dimple or pit in the center. The infection is caused by a DNA poxvirus called the MC virus. Although MC generally occurs in children, it has also been reported in immunocompromised and atopic patients. Read More

    Molecular Screening and Single Nucleotide Polymorphism Typing of Molluscum Contagiosum Virus (MCV) from Genital Specimens, between 2012 and 2015
    Iran Biomed J 2017 08 15. Epub 2017 Aug 15.
    Research and Development (R&D) Department, Keyvan Virology Specialty Laboratory (KVSL), Tehran, Iran.
    Background: The present study is the first comprehensive report of the Molluscum contagiosum virus (MCV) in Iran based on the molecular technique for differentiation and typing of the MCV1 and MCV2.

    Methods: Patients were diagnosed as having tumor-like genital warts less than 5 mm in diameter, and HIV seronegative samples were chosen for this cross-sectional study. TaqMan real-time PCR was used to identify MCV following clinical examination. Read More

    Poxviruses Utilize Multiple Strategies to Inhibit Apoptosis.
    Viruses 2017 Aug 8;9(8). Epub 2017 Aug 8.
    Department of Biological Sciences, Seton Hall University, South Orange, NJ 07039, USA.
    Cells have multiple means to induce apoptosis in response to viral infection. Poxviruses must prevent activation of cellular apoptosis to ensure successful replication. These viruses devote a substantial portion of their genome to immune evasion. Read More

    ▽ Strontium ranelate discontinued.
    • Authors:
    Drug Ther Bull 2017 Aug 2. Epub 2017 Aug 2.
    ▼ Strontium ranelate discontinued ● Limited treatment options for molluscum contagiosum ● Finasteride drug safety alert ● Does doxycycline delay the next COPD exacerbation? ● Support for WHO standards on reporting clinical trial results ● Delayed antibiotic prescription for lower respiratory tract infections ● Nystatin dose change - much ado about nothing? Read More

    Molluscum Contagiosum-Like Presentation of Langerhans Cell Histiocytosis: A Case and Review.
    Pediatr Dermatol 2017 Sep 21;34(5):e288-e289. Epub 2017 Jul 21.
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
    Langerhans cell histiocytosis (LCH) is a rare disorder characterized by clonal proliferation of Langerhans cells in the skin. A molluscum-like presentation of cutaneous LCH is rare but important to consider for examination and management. We present an atypical molluscum-like LCH case and review the literature for common features of this unusual presentation. Read More

    Characterization of Eptesipoxvirus, a novel poxvirus from a microchiropteran bat.
    Virus Genes 2017 Jul 6. Epub 2017 Jul 6.
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
    The genome of Eptesipoxvirus (EPTV) is the first poxvirus genome isolated from a microbat. The 176,688 nt sequence, which is believed to encompass the complete coding region of the virus, is 67% A+T and is predicted to encode 191 genes. 11 of these genes have no counterpart in GenBank and are therefore unique to EPTV. Read More

    A novel homozygous DOCK8 mutation associated with unusual coexistence of gross molluscum contagiosum and epidermodysplasia verruciformis in a DOCK8 deficiency patient.
    J Eur Acad Dermatol Venereol 2017 Nov 3;31(11):e504-e505. Epub 2017 Jul 3.
    Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.

    Urologic Dermatology: a Review.
    Curr Urol Rep 2017 Aug;18(8):62
    Virginia Mason Medical Center, Seattle, WA, USA.
    Purpose Of Review: Genital dermatology represents a challenge to many providers. Though dermatologic lesions involving the genitalia may present to any of a number of practices, ranging from primary care to urology, gynecology, and dermatology, few training programs provide significant training regarding the diagnosis and management of genital dermatologic lesions. The purpose of this review is to provide urologists with an overview of common genital dermatological lesions that may be encountered in a clinic. Read More

    Recombination events and variability among full-length genomes of co-circulating molluscum contagiosum virus subtypes 1 and 2.
    J Gen Virol 2017 May 30;98(5):1073-1079. Epub 2017 May 30.
    4​Centro de Investigación en Sanidad Animal; Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Valdeolmos, Madrid 28130, Spain.
    Molluscum contagiosum virus (MCV) is the sole member of the Molluscipoxvirus genus and causes a highly prevalent human disease of the skin characterized by the formation of a variable number of lesions that can persist for prolonged periods of time. Two major genotypes, subtype 1 and subtype 2, are recognized, although currently only a single complete genomic sequence corresponding to MCV subtype 1 is available. Using next-generation sequencing techniques, we report the complete genomic sequence of four new MCV isolates, including the first one derived from a subtype 2. Read More

    Molluscum Contagiosum of the Gluteal Cleft: Observations and Implications for Management in Five Children.
    Pediatr Dermatol 2017 Jul 25;34(4):e191-e195. Epub 2017 May 25.
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, Illinois.
    Molluscum contagiosum (MC) is a common, self-limited skin infection caused by a double-stranded DNA virus of the family Poxviridae. Although the morphology of the disease is well described, MC presenting at unusual sites can exhibit atypical morphology, resulting in misdiagnosis. This observational, retrospective case series discusses the novel morphology of MC presenting in the intergluteal cleft of five children seen in the outpatient dermatology clinic of an academic medical center. Read More

    Multiple sclerosis treatment with fingolimod: profile of non-cardiologic adverse events.
    Acta Neurol Belg 2017 Dec 20;117(4):821-827. Epub 2017 May 20.
    Department of Neurology, Medical School, UNIMES, Universidade Metropolitana de Santos, Avenida Conselheiro Nebias 536, Santos, SP, CEP 11045-002, Brazil.
    Fingolimod was the first oral medication approved for management of multiple sclerosis and is currently used by tens of thousands patients worldwide. Fingolimod acts via the sphingosine 1-phosphate (S1P) receptor, maintaining peripheral lymphocytes entrapped in the lymph nodes. In consequence, there is a reduction in the infiltration of aggressive lymphocytes into the central nervous system. Read More

    Molluscum Contagiosum: An Update.
    Recent Pat Inflamm Allergy Drug Discov 2017 ;11(1):22-31
    Department of Paediatrics, The Chinese University of Hong Kong, Shatin. Hong Kong.
    Background: Molluscum contagiosum is a viral cutaneous infection in childhood that occurs worldwide. Physicians should familiarize themselves with this common condition.

    Objective: To review in depth the epidemiology, pathophysiology, clinical manifestations, complications and, in particular, treatment of molluscum contagiosum. Read More

    Molluscum Contagiosum Virus MC159 Abrogates cIAP1-NEMO Interactions and Inhibits NEMO Polyubiquitination.
    J Virol 2017 Aug 12;91(15). Epub 2017 Jul 12.
    Department of Microbiology, University of Illinois, Urbana-Champaign, Urbana, Illinois, USA
    Molluscum contagiosum virus (MCV) is a dermatotropic poxvirus that causes benign skin lesions. MCV lesions persist because of virally encoded immune evasion molecules that inhibit antiviral responses. The MCV MC159 protein suppresses NF-κB activation, a powerful antiviral response, via interactions with the NF-κB essential modulator (NEMO) subunit of the IκB kinase (IKK) complex. Read More

    Interventions for cutaneous molluscum contagiosum.
    Cochrane Database Syst Rev 2017 05 17;5:CD004767. Epub 2017 May 17.
    Department of General Practice, Erasmus Medical Center, PO Box 2040, Room Ff303, Rotterdam, Netherlands, 3000 CA.
    Background: Molluscum contagiosum is a common skin infection that is caused by a pox virus and occurs mainly in children. The infection usually resolves within months in people without immune deficiency, but treatment may be preferred for social and cosmetic reasons or to avoid spreading the infection. A clear evidence base supporting the various treatments is lacking. Read More

    Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation.
    J Virol 2017 Aug 12;91(15). Epub 2017 Jul 12.
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    Molluscum contagiosum virus (MCV), the only known extant human-adapted poxvirus, causes a long-duration infection characterized by skin lesions that typically display an absence of inflammation despite containing high titers of live virus. Despite this curious presentation, MCV is very poorly characterized in terms of host-pathogen interactions. The absence of inflammation around MCV lesions suggests the presence of potent inhibitors of human antiviral immunity and inflammation. Read More

    [African histoplamosis. A report of three pediatric cases].
    J Mycol Med 2017 Jun 24;27(2):133-138. Epub 2017 Apr 24.
    Faculté des sciences de la santé, université Marien-Ngouabi, Brazzaville, Congo; Laboratoire de biologie médicale, unité d'anatomie pathologique, CHU de Brazzaville, Brazzaville, Congo.
    Histoplasmosis duboisii (Histoplasma capsulatum var duboisii) is uncommon disease especially in children. It is observed in Africa where the incidence is unknown. The authors report a series of three pediatric cases. Read More

    Clinico-epidemiological profile of patients attending Suraksha Clinic of tertiary care hospital of North India.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):54-59
    Department of Skin and STD, Government Medical College, Amritsar, Punjab, India.
    Background: Sexually transmitted infections (STIs) are a global health problem. Trends of STIs vary from place to place depending on various epidemiological factors prevailing in that respective geographic area.

    Aims And Objectives: The present study was conducted to find the pattern and prevalence of different STIs out of total STI clinic attendees, to identify any change in the trend of STIs, various epidemiological factors, and behavior of individual diseases. Read More

    The molluscum contagiosum virus death effector domain containing protein MC160 RxDL motifs are not required for its known viral immune evasion functions.
    Virus Genes 2017 Aug 20;53(4):522-531. Epub 2017 Apr 20.
    Department of Biological Sciences, Seton Hall University, 400 South Orange Ave., South Orange, NJ, 07039, USA.
    The molluscum contagiosum virus (MCV) uses a variety of immune evasion strategies to antagonize host immune responses. Two MCV proteins, MC159 and MC160, contain tandem death effector domains (DEDs). They are reported to inhibit innate immune signaling events such as NF-κB and IRF3 activation, and apoptosis. Read More

    Review of poxvirus: emergence of monkeypox.
    Med Sante Trop 2017 Feb;27(1):29-39
    Service de dermatologie, HIA Sainte-Anne, Toulon, France.
    This article reviews the different types of poxvirus infections. Smallpox, although eradicated, must continue to be monitored because of the potential risk of accidental or voluntary (by bioterrorism) reintroduction. Monkeypox and cowpox viruses are considered to be emergent today ; their high risk of dissemination is due to the increase in international transport as well as trends for new animals as pets and the loss of vaccinal protection against smallpox. Read More

    Skin diseases of the vulva: Infectious diseases.
    J Obstet Gynaecol 2017 Oct 11;37(7):840-848. Epub 2017 Apr 11.
    a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.
    A multitude of infectious diseases of viral (genital herpes, herpes zoster, genital warts and molluscum contagiosum), bacterial (syphilis, chancroid, lymphogranuloma venereum, donovanosis, erysipelas, cellulitis and necrotising fasciitis, folliculitis, impetigo, bartholin gland abscess, trichomycosis and erythrasma), fungal (candidiasis and dermatophytosis) and parasitic (pediculosis pubis) origin may affect the vulvar area. Herein, we review the infections and their skin manifestations in the vulvar area. Read More

    Molluscum Contagiosum Treated with Dilute Povidone-Iodine: A Series of Cases.
    J Clin Aesthet Dermatol 2017 Mar 1;10(3):41-45. Epub 2017 Mar 1.
    Veloce BioPharma LLC;; Plessen Ophthalmology Consultants.
    Objective: To report our experience using a broad spectrum antimicrobial, povidone-iodine, as a novel at-home prescription treatment for molluscum contagiosum. Design/Setting: A systematic review of cases presenting to one of the author's private dermatology clinics from January to July of 2015 identified 12 patients with molluscum contagiosum seeking treatment. Participants: The population was pediatric, with six males and six female patients included (age range 2-17 years, mean age 6 years). Read More

    Infectious diseases prevalence, vaccination coverage, and diagnostic challenges in a population of internationally adopted children referred to a Tertiary Care Children's Hospital from 2009 to 2015.
    Medicine (Baltimore) 2017 Mar;96(12):e6300
    Department of Health Sciences, University of Florence, Meyer Children's University Hospital, Florence, Italy.
    Infectious diseases are common in internationally adopted children (IAC).With the objective to evaluate infectious diseases prevalence in a large cohort of IAC and to explore possible risk factors for tuberculosis (TB) and parasitic infections, clinical and laboratory data at first screening visit of all IAC (<18 years) consecutively referred to our Center in 2009 to 2015 were collected and analyzed.In total, 1612 children (median age: 5. Read More

    Botanicals With Dermatologic Properties Derived From First Nations Healing: Part 2-Plants and Algae.
    J Cutan Med Surg 2017 Jul/Aug;21(4):299-307. Epub 2016 Dec 19.
    2 The Department of Dermatology & Skin Science, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
    Introduction: Plants and algae have played a central role in the treatment of skin conditions in both traditional First Nations healing and in modern dermatology. The objective of this study was to examine the evidence supporting the dermatological use of seaweed, witch hazel, bearberry, and mayapple.

    Methods: Four plants and algae used in traditional First Nations treatments of skin disease were selected based on expert recommendations. Read More

    Molluscum Contagiosum of Cervix - A Case Report.
    J Clin Diagn Res 2017 Jan 1;11(1):ED03-ED04. Epub 2017 Jan 1.
    Professor, Department of Medicine, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research , Kolar, Karnataka. India .
    Molluscum Contagiosum (MC) is a common viral infection of skin caused by a double stranded DNA Pox virus affecting both adults and children. MC is primarily an infection of school-going children (one to five years), occasionally it affects adults and immunocompromised individuals. Transmission of virus occurs by direct contact with infected persons or contaminated objects. Read More

    The Molluscum Contagiosum Virus protein MC163 localizes to the mitochondria and dampens mitochondrial mediated apoptotic responses.
    Virology 2017 May 21;505:91-101. Epub 2017 Feb 21.
    Department of Biological Sciences, Seton Hall University, 400 S. Orange Ave, South Orange, NJ 07079, United States. Electronic address:
    Apoptosis is a powerful host cell defense to prevent viruses from completing replication. Poxviruses have evolved complex means to dampen cellular apoptotic responses. The poxvirus, Molluscum Contagiosum Virus (MCV), encodes numerous host interacting molecules predicted to antagonize immune responses. Read More

    Common Skin Conditions in Children: Skin Infections.
    FP Essent 2017 Feb;453:26-32
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin infections account for a significant subset of dermatologic conditions of childhood. Common cutaneous viral infections in children include warts, molluscum contagiosum, hand-foot-and-mouth disease, and herpes simplex. Although viral infections are self-limited and often only mildly symptomatic, they can cause anxiety, embarrassment, and health care use. Read More

    [Sexuality Risk Factors among People with Suspect of Sexually Transmitted Disease].
    Rev Esp Salud Publica 2017 Jan 25;91. Epub 2017 Jan 25.
    Departamento de Enfermería, Facultad de Ciencias de la Salud, Universidad de Granada. España. Granada España.
    Objective: Describing determinants factors in Sexually Transmitted Diseases is necessary to evaluate and design effective measures for prevention and treatment. The aim of this research was to determine the sexual risk factors of people who are treated at Sexually Transmitted Diseases Centre and to analyze differences based on gender.

    Methods: Cross-sectional study on 496 clinical reports, period of time 2010 to 2014, of people who come to the Sexually Transmitted Diseases and Sexual Orientation Centre of Granada, for suspected of Sexually Transmitted Diseases. Read More

    Genomic identification of human vaccinia virus keratoconjunctivitis and its importance as a laboratory-acquired infection.
    Indian J Ophthalmol 2016 Nov;64(11):806-812
    Department of Pathobiology, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran.
    Context: Vaccinia virus (VACV) is a member of orthopoxvirus genus of the family Poxviridae. VACVs are enveloped, double-stranded DNA viruses. Several species of this family, for example, molluscum contagiosum, smallpox, deerpox, horsepox, rabbitpox, and VACVs may cause conjunctivitis. Read More

    Acral manifestations of viral infections.
    Clin Dermatol 2017 Jan - Feb;35(1):40-49. Epub 2016 Sep 10.
    Emeritus Professor of Gazi University, Faculty of Medicine, Department of Dermatology, Beşevler, Ankara, Turkey.
    Viruses are considered intracellular obligates with a nucleic acid RNA or DNA. They have the ability to encode proteins involved in viral replication and production of the protective coat within the host cells but require host cell ribosomes and mitochondria for translation. The members of the families Herpesviridae, Poxviridae, Papovaviridae, and Picornaviridae are the most commonly known agents for cutaneous viral diseases, but other virus families, such as Adenoviridae, Togaviridae, Parvoviridae, Paramyxoviridae, Flaviviridae, and Hepadnaviridae, can also infect the skin. Read More

    [New subtype of molluscipoxvirus detected].
    Lakartidningen 2016 11 28;113. Epub 2016 Nov 28.
    Sahlgrenska universitetssjukhuset - Laboratoriemedicin Goteborg, Sweden Sahlgrenska universitetssjukhuset - Laboratoriemedicin Goteborg, Sweden.
    Molluscum contagiosum is a viral infection of the epidermis characterized by skin-colored papules or nodules frequently with a central depression. Atypical variants may occur, primarily in immunosuppressed individuals. We here report a case of »giant Molluscum contagiosum« in an immunocompetent child. Read More

    A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction.
    Mol Genet Genomic Med 2016 Nov 17;4(6):604-616. Epub 2016 Sep 17.
    Baylor-Hopkins Center for Mendelian Genomics (BHCMG) of the Department of Molecular and Human GeneticsBaylor College of MedicineHoustonTexas; Norwegian National Unit for Newborn ScreeningDivision of Children and Adolescent MedicineOslo University HospitalOsloNorway.
    Background: Four patients from three Norwegian families presented with a common skin phenotype of warts, molluscum contagiosum, and dermatitis since early childhood, and various other immunological features. Warts are a common manifestation of human papilloma virus (HPV), but when they are overwhelming, disseminated and/or persistent, and presenting together with other immunological features, a primary immunodeficiency disease (PIDD) may be suspected.

    Methods And Results: The four patients were exome sequenced as part of a larger study for detecting genetic causes of primary immunodeficiencies. Read More

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