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Australas J Dermatol 2019 Apr 22. Epub 2019 Apr 22.

Skin and Cancer Foundation Inc, Melbourne, Victoria, Australia.

Actas Dermosifiliogr 2019 Apr 7. Epub 2019 Apr 7.

Hospital Dermatológico Internacional, Madrid, España.

Int J Dermatol 2019 Mar 29. Epub 2019 Mar 29.

Department of Dermatology, St. John's Medical College Hospital, Bangalore, India.

Background: Human immunodeficiency virus (HIV) infection in children is becoming a common occurrence. Worldwide, limited studies have been done on the mucocutaneous manifestations in HIV-positive children. The aim of our study was to analyze the spectrum of mucocutaneous manifestations of pediatric HIV infection and correlate to degree of immunosuppression. Read More

J Clin Aesthet Dermatol 2019 Feb 1;12(2):27-30. Epub 2019 Feb 1.

Dr. Del Rosso is Research Director of JDR Dermatology Research in Las Vegas, Nevada; is with Thomas Dermatology in Las Vegas, Nevada; and is Adjunct Clinical Professor (Dermatology) with Touro University Nevada in Henderson, Nevada.

Topical application of cantharidin, a vesicant that is naturally derived from the blister beetle, has a long track record of being used to treat primarily cutaneous molluscum contagiosum and Verrucae. Although not approved by the United States Food and Drug Administration, cantharidin has been available through a variety of compounding sources without standardization of manufacturing, formulation, or method of application. Randomized, controlled studies assessing safety and efficacy of topical cantharidin are limited, to date, with the majority of published evidence gleaned from collective clinical experience. Read More

J Eur Acad Dermatol Venereol 2019 Mar 15. Epub 2019 Mar 15.

Department of Dermatology, University Hospital, Brest, 29200, France.

Rev Prat 2018 Jun;68(6):637

Service médical de la force d'action navale, Toulon, France.

Dermatol Surg 2019 Mar;45(3):480-482

Maryland Laser Skin & Vein Institute, Hunt Valley, Maryland Maryland Laser Skin & Vein Institute, Hunt Valley, Maryland Department of Dermatology University of Maryland School of Medicine, Baltimore, Maryland.

Int J Hematol 2019 May 8;109(5):603-611. Epub 2019 Mar 8.

Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

X-Linked severe combined immunodeficiency (X-SCID) is a severe form of primary immunodeficiency characterized by absence of T cells and NK cells. X-SCID is caused by a loss-of-function mutation in the IL2RG gene that encodes common gamma chain (γc), which plays an essential role in lymphocyte development. We report the first case of hypomorphic X-SCID caused by a synonymous mutation in the IL2RG gene leading to a splice anomaly, in a family including two patients with diffuse cutaneous warts, recurrent molluscum contagiosum, and mild respiratory infections. Read More

J Virol 2019 Mar 6. Epub 2019 Mar 6.

Department of Virology University of Helsinki and Helsinki University Hospital Helsinki, Finland

MC159 is a viral FLIP (FLICE inhibitory protein) encoded by the molluscum contagiosum virus (MCV) enabling MCV to evade antiviral immunity and to establish persistent infections in humans. Here we show that MC159 contains a functional SH3 binding motif, which mediates avid and selective binding to SH3BP4, a signaling protein known to regulate endocytic trafficking and suppress cellular autophagy. The capacity to bind SH3BP4 was dispensable for regulation of NF-κB-mediated transcription and suppression of pro-apoptotic caspase activation, but contributed to inhibition of amino acid starvation-induced autophagy by MC159. Read More

Br J Dermatol 2019 Mar;180(3):e68

Department of Dermatovenereology, Sichuan University, Chengdu, 610041, China.

J Am Acad Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Dr. D. Y. Patil Medical College, Hospital & Research Centre, Pimpri, Pune-411018, India.

Open Access Maced J Med Sci 2019 Jan 28;7(2):269-271. Epub 2019 Jan 28.

University of Rome G. Marconi, Rome, Italy.

Background: Molluscum contagiosum is a common viral disease primarily affecting children.

Aim: The objective is to compare the efficacy of 10% potassium hydroxide (KOH) solution versus 10% salicylic pomade in the treatment of molluscum contagiosum.

Methods: Clinical trials on 70 patients were randomised into 2 groups: 39 patients treated with 10% KOH solution and 31 patients treated with 10% salicylic pomade. Read More

Br J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, U.K.

G Ital Dermatol Venereol 2019 Feb 4. Epub 2019 Feb 4.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

J Dermatolog Treat 2019 Jan 22:1-7. Epub 2019 Jan 22.

a Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAPJGol) , Barcelona , Spain.

Introduction: Our objective was to assess efficacy, safety and tolerance of topical potassium hydroxide (KOH) 10% for treating Molluscum contagiosum (MC) in children.

Material And Methods: Randomized, double-blind, placebo-controlled clinical trial including all children 2-16 years with MC infection attending pediatrician primary healthcare visits. The treatment was KOH 10% gel applied once daily up to clearing (maximum 30 days). Read More

Indian J Sex Transm Dis AIDS 2018 Jul-Dec;39(2):139-140

Department of Dermatology, Dr. D Y Patil Medical College and Hospital, Pune, Maharashtra, India.

Restoration of specific immune responses by combined antiretroviral therapy (cART) in patients infected with human immunodeficiency virus (HIV) may paradoxically cause an inflammatory reaction known as immune reconstitution inflammatory syndrome (IRIS). We report the emergence of giant nodules of molluscum contagiosum (MC) on the face and thighs 2 months after initiation of cART in a 45-year-old male patient with acquired immune deficiency syndrome. To the best of our knowledge, our report describes the first case of MC probably unmasked during IRIS from India. Read More

Indian J Sex Transm Dis AIDS 2018 Jul-Dec;39(2):102-106

Department of Dermatology, Venereology and Leprosy, Civil Hospital, Amritsar, Punjab, India.

Introduction: Molluscum contagiosum (MC) is a cutaneous viral infection caused by a poxvirus, manifested by discrete, papular, pearly lesions with central umbilication. Genital lesions are mainly transmitted sexually. Till date, several forms of medical and surgical therapies have been used with variable success. Read More

J Family Med Prim Care 2018 Sep-Oct;7(5):1100-1102

Department of Surgery, AIIMS, Bhopal, Madhya Pradesh, India.

Molluscum contagiosum is a very common skin and mucosal disease of viral origin, caused by molluscum contagiosum virus (MCV) 0 of poxvirus family. With the eradication of smallpox, MCV is the only member of the poxvirus family that causes substantial disease in humans. Although frequently reported, its unusual clinical presentation makes its diagnosis a challenging task. Read More

Saudi J Ophthalmol 2018 Oct-Dec;32(4):338-340. Epub 2018 Feb 8.

Oculoplastics and Orbit Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Molluscum contagiosum is a benign viral cutaneous infection. It typically presents as an asymptomatic centrally umbilicated nodule 3-5 mm in diameter. Susceptible patients are children and adults receiving immunosuppressive therapy. Read More

Transpl Infect Dis 2019 Apr 26;21(2):e13036. Epub 2018 Dec 26.

Department of Dermatology, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

We present a case of a 15-year-old girl with an allogenic renal transplant secondary to chronic glomerulonephritis of unknown etiology who presented with treatment refractory molluscum contagiosum of the lower extremities and perineum. Treatment of mollusca with pulsed dye laser resulted in a clinically significant and sustained response. To our knowledge, this is the first report of a successful treatment of molluscum contagiosum with pulsed dye laser in the setting of a renal transplant. Read More

Open Forum Infect Dis 2018 Nov 12;5(11):ofy298. Epub 2018 Nov 12.

Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Slovenia.

Molluscum contagiosum (MC) manifests as small, umbilicated papules caused by the molluscum contagiosum virus (MCV). The extent of clinical misdiagnosis of MC is unknown. Combined clinical, histopathological, and virological evaluation of 203 consecutive patients with clinical diagnosis of MC treated at a university hospital during a 5-year period showed the correct clinical diagnosis in 188 of 203 (92. Read More

Viruses 2018 10 26;10(11). Epub 2018 Oct 26.

Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, SI-1000 Ljubljana, Slovenia.

Molluscum contagiosum virus (MCV) is the sole member of the genus and the causative agent of molluscum contagiosum (MC), a common skin disease. Although it is an important and frequent human pathogen, its genetic landscape and evolutionary history remain largely unknown. In this study, ten novel complete MCV genome sequences of the two most common MCV genotypes were determined (five MCV1 and five MCV2 sequences) and analyzed together with all MCV complete genomes previously deposited in freely accessible sequence repositories (four MCV1 and a single MCV2). Read More

Cutis 2018 Sep;102(3):191-194

Departments of Dermatology and Pediatrics, Mt Sinai St. Luke's of the Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Predisposition to cutaneous viral infections is known to be a minor criterion of Hanifin and Rajka's diagnostic standard of atopic dermatitis (AD); however, the causal relationship between molluscum contagiosum virus (MCV) infection and AD onset or aggravation has not been widely explored. The objective of this study was to identify pediatric patients with AD onset or flare triggered by MCV infection as well as to characterize the setting under which MCV may trigger AD onset or flares in children. Fifty children with prior or current MCV infection presenting sequentially to an outpatient pediatric dermatology practice over a 1-month period were evaluated. Read More

Skinmed 2018 1;16(4):247-254. Epub 2018 Jul 1.

JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong.

We aimed to investigate roles of dermatoscopy in skin infections, with Part 1 of our report covering viral and bacterial infections. A case-control study was conducted on the medical records of all patients with skin infections who had had dermatoscopy performed over a period of 3 months. Our control participants were all patients with skin infections in two 3-month periods, and sex-pair-matched patients with the same infections, who had not undergone dermatoscopy. Read More

J Dtsch Dermatol Ges 2018 Sep;16(9):1144-1146

Institut für Virologie, Universitätsklinikum des Saarlandes, Homburg/Saar, Deutschland.

Dermatol Ther 2018 09 28;31(5):e12630. Epub 2018 Aug 28.

Mansoura Dermatology, Venerology and Leprology Hospital, Mansoura, Egypt.

Indian J Sex Transm Dis AIDS 2017 Jul-Dec;38(2):147-151

Department of Dermatology, Venereology and Leprology, Government Medical College, Kota, Rajasthan, India.

Background: Knowledge about the current patterns of sexually transmitted infections (STIs) is essential as they pose a major health problem worldwide and even more so in the developing countries like ours. Owing to the lack of advanced laboratory facilities at most of the centers, the cases are evaluated and managed as per the syndromic approach proposed by the National AIDS Control Organization.

Aims: We aim to study the patterns of STIs seen over the past 4 years based on the syndromic approach. Read More

Dermatol Online J 2018 Aug 23;24(6). Epub 2018 Aug 23.

Pediatrics, Johns Hopkins Children's Center, Baltimore, Maryland.

We discuss imiquimod associated with non-application site mucosal reactions and two of our own clinical cases. In one of our patients, erosive cheilitis developed in a young boy after using topical imiquimod 5% cream for 5 nights weekly on bilateral cheeks, chin, and near vermillion border for molluscum contagiosum. The case is discussed with concerns for imiquimod use in molluscum contagiosum when used near mucosal surfaces. Read More

J Dtsch Dermatol Ges 2018 Sep 21;16(9):1143-1145. Epub 2018 Aug 21.

Institute of Virology, Saarland University Medical Center, Homburg/Saar, Germany.

Prim Care 2018 Sep;45(3):433-454

Department of Family Medicine, Tidelands Health MUSC Family Medicine Residency Program, 4320 Holmestown Road, Myrtle Beach, SC 29588, USA.

The primary care provider will commonly see skin and soft tissue infections in the outpatient setting. Skin and soft tissue infections range from the uncomplicated impetigo to the potentially lethal necrotizing fasciitis. This article reviews these infections based on their underlying etiology: bacterial, fungal, and viral causes. Read More

Sports Health 2019 Jan/Feb;11(1):47-58. Epub 2018 Aug 14.

University of Minnesota, Minneapolis, Minnesota.

Context:: Infections are common in contact sports. This review aims to describe the epidemiology, presenting signs and symptoms, treatment guidelines, and regulations for several common infections seen in contact sport athletes. The conditions discussed include bacterial skin infections, herpes simplex virus, molluscum contagiosum, common warts, tinea, scabies, head lice, conjunctivitis, human immunodeficiency virus, hepatitis C virus, and vaccine-preventable illnesses. Read More

Am J Clin Dermatol 2018 Dec;19(6):791-803

Department of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, 676N. Saint Clair St, Suite 1600, Chicago, IL, 60611, USA.

Background And Objective: Topical cantharidin is routinely used for the treatment of molluscum contagiosum and warts. The objective of this systematic review is to assess the efficacy and safety of topical cantharidin treatment for molluscum contagiosum and warts.

Methods: We performed a systematic review of studies assessing topical cantharidin treatment of molluscum contagiosum or warts. Read More

Skin Res Technol 2019 Jan 18;25(1):106-107. Epub 2018 Jul 18.

Department of Dermatology, Hospital de Santa Maria, Lisboa, Portugal.

Juvenile xanthogranuloma is the most common type of non-Langerhans cell histiocytosis. It appears primarily in infancy, where its differential diagnosis includes Spitz nevus, dermal nevus and molluscum contagiosum. We report the case of a 2-year-old boy with juvenile xanthogranuloma, as diagnosed using real-time, in vivo reflectance confocal microscopy. Read More

Dermatol Ther 2018 09 17;31(5):e12658. Epub 2018 Jul 17.

Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Klin Monbl Augenheilkd 2018 Jul 11;235(7):776-781. Epub 2018 Jul 11.

Augenheilkunde, Universitäts-Augenklinik Bonn.

Background: Lid tumors show a heterogenous clinical spectrum. Tumors which display some criteria of malignancy may histologically be diagnosed as inflammatory lesions without any neoplastic component. In contrast, malignant tumors can induce changes on the lid margin mimicking inflammatory changes. Read More

Sci Rep 2018 Jul 5;8(1):10145. Epub 2018 Jul 5.

Center for Reproduction, 181st Hospital of Chinese People's Liberation Army, Guilin, 541001, China.

Podophyllotoxin is used as medical cream which is widely applied to genital warts and molluscum contagiosum. Although previous study showed that podophyllotoxin had minimal toxicity, it was forbidden to use during pregnancy since it might be toxic to the embryos. In present study we used mouse as the model and tried to examine whether podophyllotoxin exposure was toxic to oocyte maturation, which further affected embryo development. Read More

Pediatr Dermatol 2018 Sep 4;35(5):e310-e311. Epub 2018 Jul 4.

Section of Dermatology, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

Molluscum contagiosum within a congenital melanocytic nevus has rarely been reported. We report a 6-year-old child with molluscum contagiosum infection arising within an intermediate melanocytic congenital nevus of the thigh, associated with itching and occasional bleeding. Dermoscopy lead to the correct diagnosis, but histologic confirmation with shave biopsy was performed to reassure the parents and allow mechanical removal of the lesions using curettage. Read More

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

J Family Med Prim Care 2018 Jan-Feb;7(1):267-270

Department of Internal Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.

Eruptive xanthomatosis is described as the sudden eruption of erythematous yellow papules in the presence of hypertriglyceridemia, often associated with serum triglyceride levels above 2000 mg/dl. Severe hypertriglyceridemia can be caused by primary genetic mutations, secondary chronic diseases, or a combination of both. Uncontrolled diabetes mellitus is a known risk factor. Read More

Int J Dermatol 2018 Aug 15;57(8):1001-1006. Epub 2018 Jun 15.

Department of Internal Medicine, Division of Dermatology, Albert Einstein College of Medicine, Bronx, NY, USA.

Topical cantharidin is a commonly used treatment for molluscum contagiosum (MC). However, studies validating its safety and efficacy are limited. We conducted a 6-week, randomized, double-blind, placebo-controlled trial with subsequent open-label extension to assess the safety and effectiveness of cantharidin in treating pediatric MC. Read More

J Dermatol 2018 Aug 13;45(8):994-999. Epub 2018 Jun 13.

Department of Dermatology, Rambam Health Care Campus, Technion, Haifa, Israel.

Staphylococcus lugdunensis is an emerging pathogen in skin and soft tissue infections that was previously considered a commensal. The aim of this study was to elucidate the characteristics of skin infections by S. lugdunensis and its appropriate management, in a tertiary referral medical center. Read More

Acta Ophthalmol 2018 Aug 31;96(5):e600-e605. Epub 2018 May 31.

Goldschleger Eye Institute, Sackler Faculty of Medicine, Tel-Aviv University, Sheba Medical Center, Tel Hashomer, Israel.

Purpose: To describe the different clinical presentations of periocular molluscum contagiosum (MC) lesions and their epidemiological, clinical and histopathological features.

Methods: Medical records and histopathological sections of all cases of periocular MC treated at the oculoplastic clinic of the Goldschleger Eye Institute, Sheba Medical Center, Israel, between 1995 and 2016 were retrospectively reviewed. The following data were extracted: gender, age at the time of MC diagnosis, immune competency, location of the periocular lesions, number of lesions, dimensions of the lesions, clinical presentation, histopathological features, suspected clinical diagnosis before histopathological diagnosis and treatment. Read More

Br J Dermatol 2018 05;178(5):e328

Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, U.S.A.

Acta Dermatovenerol Croat 2018 Apr;26(1):75-76

Antigona Begolli Gerqari, MD, Dermatovenerology Clinic, University Clinical Center 10000 Pristina , Republic of Kosovo;

Tattooing is a procedure where ink is applied to an area of the skin, mostly intraepidermally (1). This procedure is carried out mainly for aesthetic purposes. Lately, it has been used as a corrective medical procedure following amputation of mammilla. Read More

Diagn Cytopathol 2018 Sep 7;46(9):794-796. Epub 2018 May 7.

Department of Dermatology, Lady Hardinge Medical College, Delhi, India.

Molluscum contagiosum (MC) is most frequently a self-limiting benign viral skin disease. Transmitted by direct skin contact, it is characterized by flesh-colored, dome-shaped, umbilicated lesions. Diagnosis of MC is often done clinically, but when needed, biopsy can be performed, in which characteristic Henderson-Patterson bodies, representing intracytoplasmic assemblies of the virus, are pathognomonic. Read More

Acta Derm Venereol 2018 Aug;98(8):824-825

Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

J Dermatol 2018 Oct 18;45(10):e268-e269. Epub 2018 Apr 18.

Department of Dermatology, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan.

An Pediatr (Barc) 2019 Feb 13;90(2):126-127. Epub 2018 Apr 13.

Pediatría, Centro de Salud de San Sadurniño, SERGAS, San Sadurniño, A Coruña, España.