Pediatr Dermatol 2017 May 25. Epub 2017 May 25.

Section of Dermatology, Department of Medicine, University of Chicago, Chicago, Illinois.

Molluscum contagiosum (MC) is a common, self-limited skin infection caused by a double-stranded DNA virus of the family Poxviridae. Although the morphology of the disease is well described, MC presenting at unusual sites can exhibit atypical morphology, resulting in misdiagnosis. This observational, retrospective case series discusses the novel morphology of MC presenting in the intergluteal cleft of five children seen in the outpatient dermatology clinic of an academic medical center. Read More

Acta Neurol Belg 2017 May 20. Epub 2017 May 20.

Department of Neurology, Medical School, UNIMES, Universidade Metropolitana de Santos, Avenida Conselheiro Nebias 536, Santos, SP, CEP 11045-002, Brazil.

Fingolimod was the first oral medication approved for management of multiple sclerosis and is currently used by tens of thousands patients worldwide. Fingolimod acts via the sphingosine 1-phosphate (S1P) receptor, maintaining peripheral lymphocytes entrapped in the lymph nodes. In consequence, there is a reduction in the infiltration of aggressive lymphocytes into the central nervous system. Read More

Recent Pat Inflamm Allergy Drug Discov 2017 May 17. Epub 2017 May 17.

Department of Paediatrics, The Chinese University of Hong Kong, Shatin. Hong Kong.

Background: Molluscum contagiosum is a viral cutaneous infection in childhood that occurs worldwide. Physicians should familiarize themselves with this common condition.

Objective: To review in depth the epidemiology, pathophysiology, clinical manifestations, complications and, in particular, treatment of molluscum contagiosum. Read More

J Virol 2017 May 17. Epub 2017 May 17.

Department of Microbiology, University of Illinois, Urbana-Champaign, Illinois, USA

Molluscum contagiosum virus (MCV) is a dermatotropic poxvirus that causes benign skin lesions. MCV lesions persist because of virally-encoded immune evasion molecules that inhibit anti-viral responses. The MCV MC159 protein suppresses NF-κB activation, a powerful anti-viral response, via interactions with the NEMO subunit of the IKK complex. Read More

Cochrane Database Syst Rev 2017 May 17;5:CD004767. Epub 2017 May 17.

Department of General Practice, Erasmus Medical Center, PO Box 2040, Room Ff303, Rotterdam, Netherlands, 3000 CA.

Background: Molluscum contagiosum is a common skin infection that is caused by a pox virus and occurs mainly in children. The infection usually resolves within months in people without immune deficiency, but treatment may be preferred for social and cosmetic reasons or to avoid spreading the infection. A clear evidence base supporting the various treatments is lacking. Read More

J Virol 2017 May 10. Epub 2017 May 10.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

Molluscum Contagiosum Virus (MCV), the only known extant, human-adapted poxvirus, causes a long-duration infection characterized by skin lesions that typically display an absence of inflammation despite containing high titres of live virus. Despite this curious presentation, MCV is very poorly characterized in terms of host-pathogen interactions. The absence of inflammation around MCV lesions suggests the presence of potent inhibitors of human anti-viral immunity and inflammation. Read More

J Mycol Med 2017 Apr 24. Epub 2017 Apr 24.

Faculté des sciences de la santé, université Marien-Ngouabi, Brazzaville, Congo; Laboratoire de biologie médicale, unité d'anatomie pathologique, CHU de Brazzaville, Brazzaville, Congo.

Histoplasmosis duboisii (Histoplasma capsulatum var duboisii) is uncommon disease especially in children. It is observed in Africa where the incidence is unknown. The authors report a series of three pediatric cases. Read More

Indian J Sex Transm Dis 2017 Jan-Jun;38(1):54-59

Department of Skin and STD, Government Medical College, Amritsar, Punjab, India.

Background: Sexually transmitted infections (STIs) are a global health problem. Trends of STIs vary from place to place depending on various epidemiological factors prevailing in that respective geographic area.

Aims And Objectives: The present study was conducted to find the pattern and prevalence of different STIs out of total STI clinic attendees, to identify any change in the trend of STIs, various epidemiological factors, and behavior of individual diseases. Read More

Virus Genes 2017 Apr 20. Epub 2017 Apr 20.

Department of Biological Sciences, Seton Hall University, 400 South Orange Ave., South Orange, NJ, 07039, USA.

The molluscum contagiosum virus (MCV) uses a variety of immune evasion strategies to antagonize host immune responses. Two MCV proteins, MC159 and MC160, contain tandem death effector domains (DEDs). They are reported to inhibit innate immune signaling events such as NF-κB and IRF3 activation, and apoptosis. Read More

Med Sante Trop 2017 Feb;27(1):29-39

Service de dermatologie, HIA Sainte-Anne, Toulon, France.

This article reviews the different types of poxvirus infections. Smallpox, although eradicated, must continue to be monitored because of the potential risk of accidental or voluntary (by bioterrorism) reintroduction. Monkeypox and cowpox viruses are considered to be emergent today ; their high risk of dissemination is due to the increase in international transport as well as trends for new animals as pets and the loss of vaccinal protection against smallpox. Read More

J Obstet Gynaecol 2017 Apr 11:1-9. Epub 2017 Apr 11.

a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.

A multitude of infectious diseases of viral (genital herpes, herpes zoster, genital warts and molluscum contagiosum), bacterial (syphilis, chancroid, lymphogranuloma venereum, donovanosis, erysipelas, cellulitis and necrotising fasciitis, folliculitis, impetigo, bartholin gland abscess, trichomycosis and erythrasma), fungal (candidiasis and dermatophytosis) and parasitic (pediculosis pubis) origin may affect the vulvar area. Herein, we review the infections and their skin manifestations in the vulvar area. Read More

J Clin Aesthet Dermatol 2017 Mar 1;10(3):41-45. Epub 2017 Mar 1.

Veloce BioPharma LLC;; Plessen Ophthalmology Consultants.

Objective: To report our experience using a broad spectrum antimicrobial, povidone-iodine, as a novel at-home prescription treatment for molluscum contagiosum. Design/Setting: A systematic review of cases presenting to one of the author's private dermatology clinics from January to July of 2015 identified 12 patients with molluscum contagiosum seeking treatment. Participants: The population was pediatric, with six males and six female patients included (age range 2-17 years, mean age 6 years). Read More

Medicine (Baltimore) 2017 Mar;96(12):e6300

Department of Health Sciences, University of Florence, Meyer Children's University Hospital, Florence, Italy.

Infectious diseases are common in internationally adopted children (IAC).With the objective to evaluate infectious diseases prevalence in a large cohort of IAC and to explore possible risk factors for tuberculosis (TB) and parasitic infections, clinical and laboratory data at first screening visit of all IAC (<18 years) consecutively referred to our Center in 2009 to 2015 were collected and analyzed.In total, 1612 children (median age: 5. Read More

Cleve Clin J Med 2017 Mar;84(3):186-187

Director, Department of Infectious Disease and Tropical Medicine, Centro Hospitalar de Lisboa Ocidental, Hospital de Egas Moniz, Lisboa, Portugal.

J Cutan Med Surg 2016 Dec 1:1203475416683390. Epub 2016 Dec 1.

2 The Department of Dermatology & Skin Science, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Introduction: Plants and algae have played a central role in the treatment of skin conditions in both traditional First Nations healing and in modern dermatology. The objective of this study was to examine the evidence supporting the dermatological use of seaweed, witch hazel, bearberry, and mayapple.

Methods: Four plants and algae used in traditional First Nations treatments of skin disease were selected based on expert recommendations. Read More

J Clin Diagn Res 2017 Jan 1;11(1):ED03-ED04. Epub 2017 Jan 1.

Professor, Department of Medicine, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research , Kolar, Karnataka. India .

Molluscum Contagiosum (MC) is a common viral infection of skin caused by a double stranded DNA Pox virus affecting both adults and children. MC is primarily an infection of school-going children (one to five years), occasionally it affects adults and immunocompromised individuals. Transmission of virus occurs by direct contact with infected persons or contaminated objects. Read More

Infection 2017 Feb 27. Epub 2017 Feb 27.

Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Virology 2017 May 21;505:91-101. Epub 2017 Feb 21.

Department of Biological Sciences, Seton Hall University, 400 S. Orange Ave, South Orange, NJ 07079, United States. Electronic address:

Apoptosis is a powerful host cell defense to prevent viruses from completing replication. Poxviruses have evolved complex means to dampen cellular apoptotic responses. The poxvirus, Molluscum Contagiosum Virus (MCV), encodes numerous host interacting molecules predicted to antagonize immune responses. Read More

FP Essent 2017 Feb;453:26-32

University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.

Skin infections account for a significant subset of dermatologic conditions of childhood. Common cutaneous viral infections in children include warts, molluscum contagiosum, hand-foot-and-mouth disease, and herpes simplex. Although viral infections are self-limited and often only mildly symptomatic, they can cause anxiety, embarrassment, and health care use. Read More

Ann Acad Med Singapore 2017 Jan;46(1):37-38

Department of Dermatology, The First Affiliated Hospital of Zhengzhou University, People's Republic of China.

Rev Esp Salud Publica 2017 Jan 25;91. Epub 2017 Jan 25.

Departamento de Enfermería, Facultad de Ciencias de la Salud, Universidad de Granada. España. Granada España.

Objective: Describing determinants factors in Sexually Transmitted Diseases is necessary to evaluate and design effective measures for prevention and treatment. The aim of this research was to determine the sexual risk factors of people who are treated at Sexually Transmitted Diseases Centre and to analyze differences based on gender.

Methods: Cross-sectional study on 496 clinical reports, period of time 2010 to 2014, of people who come to the Sexually Transmitted Diseases and Sexual Orientation Centre of Granada, for suspected of Sexually Transmitted Diseases. Read More

J Am Acad Dermatol 2017 Feb;76(2S1):S55-S56

Department of Dermatology, College of Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.

J Am Acad Dermatol 2017 Feb;76(2S1):S22-S24

Melanoma and Skin Cancer Unit, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Department of Pathology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

J Dermatol 2016 Dec 24. Epub 2016 Dec 24.

Department of Dermatology, Nishi-Kobe Medical Center, Kobe, Japan.

Indian J Ophthalmol 2016 Nov;64(11):806-812

Department of Pathobiology, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran.

Context: Vaccinia virus (VACV) is a member of orthopoxvirus genus of the family Poxviridae. VACVs are enveloped, double-stranded DNA viruses. Several species of this family, for example, molluscum contagiosum, smallpox, deerpox, horsepox, rabbitpox, and VACVs may cause conjunctivitis. Read More

Lakartidningen 2016 11 28;113. Epub 2016 Nov 28.

Sahlgrenska universitetssjukhuset - Laboratoriemedicin Goteborg, Sweden Sahlgrenska universitetssjukhuset - Laboratoriemedicin Goteborg, Sweden.

Molluscum contagiosum is a viral infection of the epidermis characterized by skin-colored papules or nodules frequently with a central depression. Atypical variants may occur, primarily in immunosuppressed individuals. We here report a case of »giant Molluscum contagiosum« in an immunocompetent child. Read More

Mol Genet Genomic Med 2016 Nov 17;4(6):604-616. Epub 2016 Sep 17.

Baylor-Hopkins Center for Mendelian Genomics (BHCMG) of the Department of Molecular and Human GeneticsBaylor College of MedicineHoustonTexas; Norwegian National Unit for Newborn ScreeningDivision of Children and Adolescent MedicineOslo University HospitalOsloNorway.

Background: Four patients from three Norwegian families presented with a common skin phenotype of warts, molluscum contagiosum, and dermatitis since early childhood, and various other immunological features. Warts are a common manifestation of human papilloma virus (HPV), but when they are overwhelming, disseminated and/or persistent, and presenting together with other immunological features, a primary immunodeficiency disease (PIDD) may be suspected.

Methods And Results: The four patients were exome sequenced as part of a larger study for detecting genetic causes of primary immunodeficiencies. Read More

Skinmed 2016 1;14(5):349-352. Epub 2016 Oct 1.

Dr Vasantrao Pawar Medical College and Research Centre, Nashik, Maharashtra, India.

Woronoff ring has been mostly discussed as a phenomenon in psoriasis, especially during therapy. It has also been reported in a few other conditions unrelated to psoriasis; however, the association of Woronoff ring has not been reported in immunocompetent, healthy, and untreated patients with molluscum contagiosum who have no apparent systemic illness. The authors report a case series of Woronoff ring seen in untreated immunocompetent patients with molluscum contagiosum involving different age groups. Read More

Diagn Cytopathol 2017 Feb 8;45(2):179-181. Epub 2016 Nov 8.

Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio.

When evaluating a Papanicolaou (Pap) smear, the cytology of the squamous epithelial cells is of utmost importance. This is what cytopathologists use to render a diagnosis, ranging from normal to atypical squamous cells of undetermined significance (ASCUS) to high grade squamous intraepithelial lesions, or even squamous cell carcinoma. However, occasionally the pathologist will run into microscopic noncellular material as in our case, such as corpora amylacea on the slides, or even uncommon viral inclusions such as Molluscum contagiosum (MCV). Read More

Indian J Dermatol Venereol Leprol 2017 Mar-Apr;83(2):265-266

Department of Dermatology, Rajiv Gandhi Medical College and Chhatrapati Shivaji Maharaj Hospital, Kalwa, Thane, Maharashtra, India.

Indian J Dermatol Venereol Leprol 2016 Nov 11. Epub 2016 Nov 11.

Department of Ophthalmology, Government Medical College, Kozhikode, Kerala, India.

Eur J Ophthalmol 2016 Oct 13;27(1). Epub 2016 Oct 13.

Department of Ophthalmology, Eye and Ear Institute, University of Pittsburgh Medical Center, Pittsburgh, PA - USA.

Purpose: To report a case of bilateral cavernous sinus thrombosis (CST) in a patient with tacrolimus-associated posttransplant thrombotic microangiopathy.

Methods: Case report.

Results: An 8-year-old boy with a medical history of orthotopic heart transplant, posttransplant lymphoproliferative disease, and recurrent infections was hospitalized for nausea, vomiting, and diarrhea. Read More

J Dermatol 2016 Nov 6;43(11):1387-1388. Epub 2016 Apr 6.

Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.

Ann Dermatol Venereol 2016 Nov 20;143(11):746-748. Epub 2016 Oct 20.

Pôle santé publique et médecine sociale, service de dermatologie et médecine sociale, hôpital La Grave, place Lange, TSA 60033, 31059 Toulouse cedex 9, France.

J Cytol 2016 Jul-Sep;33(3):163-165

Department of Pathology, Post Graduate Institute of Medical Education and Research and Dr. RML Hospital, New Delhi, India.

Disseminated histoplasmosis is caused by the dimorphic fungus Histoplasma capsulatum (H. capsulatum). The early clinical manifestations are nonspecific, often lead to diagnostic difficulty, and is misdiagnosed as tuberculosis and seen usually in immunosuppressed states. Read More

Breast J 2017 Jan 26;23(1):107-108. Epub 2016 Sep 26.

Histopathology Unit, South Devon Healthcare NHS Foundation Trust, Torquay, Devon, UK.

Acta Dermatovenerol Croat 2016 Aug;24(3):223-4

Marius Irimie, MD, 40, Zizinului Street, Bl. 31, Sc. C, Ap. 2, 500414, Brasov, Romania;

In the last twenty years, the prevalence of individuals with tattoos in the general population has increased in Europe (1) as well as in Australia (2) and the United States of America (3). A series of complications such as acute inflammatory reactions, allergic contact dermatitis (4,5), photoinduced, lichenoid, and granulomatous reactions (6, 7), pseudolymphoma (8), pseudoepitheliomatous hyperplasia (9), skin infections (6), and skin cancers (10) may occur on tattoos. Infectious complications on tattoos include bacterial infections (pyoderma, leprosy, syphilis, cutaneous tuberculosis, mycobacteriosis) (11-14), viral infections (molluscum contagiosum, warts, herpes simplex, hepatitis B and C) (15-17), and fungal infections (sporotrichosis, dermatophytosis) (18,19). Read More

Dermatol Pract Concept 2016 Jul 31;6(3):71-3. Epub 2016 Jul 31.

Department of Dermatology, Istanbul Medeniyet University School of Medicine, Goztepe Research and Training Hospital, Instanbul, Turkey.

Molluscum contagiosum is a benign cutaneous viral infection which is caused by double- stranded DNA poxvirus. It affects mainly children and young adults and usually presents with single or multiple umblicated papules or nodules on face, arms, legs and anogenital regions. It may present in atypical size and clinical appearance in patients with altered or impaired immunity and rarely in immuncompetent patients. Read More

JAMA Dermatol 2016 Sep;152(9):1072

J Dermatol 2017 Jan 8;44(1):52-58. Epub 2016 Sep 8.

Department of Pathology, Osaka Red Cross Hospital, Osaka, Japan.

Immunohistochemical studies of one typical and two atypical cases of molluscum contagiosum with anti-CD34 monoclonal antibodies showed a tightly enclosing fine vasculature around the lesional masses of the disease. The thin interstitial septa between the lobules of the molluscum lesions also contained abundant endothelium. An electron microscopic study of a pinched-off lesion of common molluscum contagiosum demonstrated that the tightly enclosing blood vessels lacked muscle layers, suggesting that they were capillaries, being a distance of several hundred nanometers from the basal cells of the molluscum mass. Read More

Pediatr Dermatol 2016 Nov 7;33(6):640-645. Epub 2016 Sep 7.

Pediatric Dermatology Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background/objectives: Molluscum contagiosum (MC) is a common viral disease primarily affecting children. The objective was to compare the effectiveness of curettage as a treatment modality for MC with no treatment.

Methods: We performed a retrospective study of 2,022 children with MC between 2008 and 2012. Read More

G Ital Dermatol Venereol 2016 Sep 6. Epub 2016 Sep 6.

Clinica Dermatologica, La Sapienza University of Rome, Rome, Italy -

Pathologists who find ectopic glands on the glans and/or on the prepuce, often describe them as Tyson's glands. In this regard, the term Tyson's glands can be replaced by two different descriptive expressions: papillomatosis corona penis and ectopic sebaceous glands. A 15-year old Caucasian male patient presented to our Institute with multiple and asymptomatic circular skin colored-to-yellowish papules at the level of the foreskin, also affecting the shaft of the penis, where they assumed a linear feature. Read More

Ophthalmology 2016 Sep;123(9):1925

Clinico Path Labs, Chembur, Mumbai, India.

Acta Derm Venereol 2017 02;97(2):291-292

Department of Dermatology, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Saitama, Japan.

J Pediatr 2016 Oct 8;177:326-326.e1. Epub 2016 Aug 8.

Department of Pediatric Dermatology University of Minnesota Minneapolis, Minnesota.

Acta Dermatovenerol Croat 2016 Jun;24(2):130-6

Katarina Trčko, MD, Department of Dermatovenereology, University Clinical Centre Maribor, Ljubljanska 5, 2000 Maribor, Slovenia;

Molluscum contagiosum virus (MCV) is a common skin pathogen in both adults and children. In this prospective study, we clinically evaluated consecutive patients with molluscum contagiosum (MC) who had been examined during a 5-year period at the second-largest dermatology clinic in Slovenia and described their main demographic and clinical characteristics, concomitant diseases, and treatment success. The study included 188 patients, of which 121 (64%) were men and 67 (36%) were women. Read More

Eur J Dermatol 2016 Aug;26(4):370-2

Infectious Diseases Unit, Clermont University, UMR CNRS 6023 Laboratoire Microorganismes: Génome Environnement (LMGE), Université d'Auvergne, CHU Clermont-Ferrand, Clermont-Ferrand, France.

Internationally adopted children often present diseases contracted in the country of origin. Skin diseases are common in new arrivals, and diagnosis may prove challenging for GPs or even dermatologists if they are inexperienced in the extensive geographic and ethnic diversity of international adoptees. To analyse the frequency and characteristics of skin diseases in international adoptees. Read More

Pediatr Dermatol 2016 Sep 11;33(5):e284-5. Epub 2016 Jul 11.

Department of Dermatology, College of Medicine, Hallym University, Seoul, Korea.

A eutectic mixture of lidocaine and prilocaine (EMLA) is used topically to provide local anesthesia for a variety of painful superficial procedures. Although the side effects of EMLA are usually mild and transient local reactions, potentially life-threatening complications can occur. We report a case of generalized seizures and methemoglobinemia after topical application of EMLA for curettage of molluscum contagiosum lesions in a 3. Read More

Br J Dermatol 2017 Mar 16;176(3):809-812. Epub 2017 Jan 16.

Department of Dermatology, No. 1 Hospital of China Medical University, 155 N. Nanjing Street, Shenyang, 110001, China.

Arch Dermatol Res 2016 Sep 2;308(7):487-92. Epub 2016 Jul 2.

Dermatology Department, American University of Beirut Medical Center, Riad El Solh St, P.O.Box 11-0236, Beirut, Lebanon.

Plasmacytoid dendritic cells (pDCs) are the most potent producers of type I interferons (IFNs), which allows them to provide anti-viral resistance and to link the innate and adaptive immunity by controlling the function of myeloid DCs, lymphocytes, and natural killer cells. pDCs are involved in the pathogenesis of several infectious [especially viral, such as Molluscum contagiosum (MC)], inflammatory/autoimmune, and neoplastic entities. Kaposi's sarcoma (KS) is a multifocal, systemic lympho-angioproliferative tumor associated with Kaposi's sarcoma-associated herpesvirus (KSHV) infection. Read More