15,422 results match your criteria Molecules [Journal]


Therapeutic Approaches of Resveratrol on Endometriosis via Anti-Inflammatory and Anti-Angiogenic Pathways.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Department of Medical and Surgical Specialties, Faculty of Medicine, Transilvania University of Brasov, 500019 Brasov, Romania.

Endometriosis represents a severe gynecological pathology, defined by implantation of endometrial glands and stroma outside the uterine cavity. This pathology affects almost 15% of women during reproductive age and has a wide range of consequences. In affected women, infertility has a 30% rate of prevalence and endometriosis implants increase the risk of ovarian cancer. Read More

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http://dx.doi.org/10.3390/molecules24040667DOI Listing
February 2019

Microbial Asymmetric Functionalization of β-Cyclocitral-Derived Tetramethyl-Substituted γ-Lactone.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.

Searching for the new anticancer compounds we prepared three new β-cyclocitral-derived hydroxyl-γ-lactones by microbial hydroxylation of tetramethyl-substituted bicyclic γ-lactone. The substrate was transformed by the enzymatic system of filamentous fungi. Three out of fifteen strains were selected as effective biocatalysts ( AM10, AM296, AM536). Read More

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http://dx.doi.org/10.3390/molecules24040666DOI Listing
February 2019

Synthesis, Physical Properties, and Reactivity of Stable, π-Conjugated, Carbon-Centered Radicals.

Authors:
Takashi Kubo

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.

Recently, long-lived, organic radical species have attracted much attention from chemists and material scientists because of their unique electronic properties derived from their magnetic spin and singly occupied molecular orbitals. Most stable and persistent organic radicals are heteroatom-centered radicals, whereas carbon-centered radicals are generally very reactive and therefore have had limited applications. Because the physical properties of carbon-centered radicals depend predominantly on the topology of the π-electron array, the development of new carbon-centered radicals is key to new basic molecular skeletons that promise novel and diverse applications of spin materials. Read More

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http://dx.doi.org/10.3390/molecules24040665DOI Listing
February 2019

Secondary Metabolites and the Risks of and .

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Key Laboratory of Bio-Pesticide Innovation and Application of Guangdong Province, College of Agriculture, South China Agricultural University, Guangzhou 510642, China.

and are important entomopathogenic fungi with a worldwide distribution and multiple host insects. However, the concerns about the safety risks of myco-pesticides have been attracting the attention of researchers and consumers. Secondary metabolites (SMs), especially the mycotoxins, closely affect the biosafety of myco-insecticides. Read More

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http://dx.doi.org/10.3390/molecules24040664DOI Listing
February 2019

A Convenient, Rapid, Sensitive, and Reliable Spectrophotometric Assay for Adenylate Kinase Activity.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Biological Science Research Center, Southwest University, Beibei, Chongqing 400715, China.

Enzymatic activity assays are essential and critical for the study of enzyme kinetics. Adenylate kinase (Adk) plays a fundamental role in cellular energy and nucleotide homeostasis. To date, assays based on different principles have been used for the determination of Adk activity. Read More

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http://dx.doi.org/10.3390/molecules24040663DOI Listing
February 2019
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Triboluminescence of Centrosymmetric Lanthanide β-Diketonate Complexes with Aggregation-Induced Emission.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hom, Kowloon 999077, Hong Kong, China.

Triboluminescence (TL) is a form of light emission induced upon mechanical forces on the material. However, our understanding of this phenomenon is still unclear and more examples are therefore needed in order to elucidate its mechanism. In this work, two types of TL complexes, [Eu(-dbm-Cl₂)₃phen] and [Eu(-dbm-Cl₂)₃phen], which also displays aggregation-induced emission (AIE) were synthesized and investigated for its photo-physical and crystal structural properties. Read More

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http://dx.doi.org/10.3390/molecules24040662DOI Listing
February 2019

Profiling Volatile Constituents of Homemade Preserved Foods Prepared in Early 1950s South Dakota (USA) Using Solid-Phase Microextraction (SPME) with Gas Chromatography⁻Mass Spectrometry (GC-MS) Determination.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Department of Chemistry, Dakota State University, Madison, SD 57042, USA.

An essential dimension of food tasting (i.e., flavor) is olfactory stimulation by volatile organic compounds (VOCs) emitted therefrom. Read More

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http://dx.doi.org/10.3390/molecules24040660DOI Listing
February 2019

Short-Term Neonatal Oral Administration of Oleanolic Acid Protects against Fructose-Induced Oxidative Stress in the Skeletal Muscles of Suckling Rats.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.

Nutritional manipulations in the neonatal period are associated with the development of negative or positive health outcomes later in life. Excessive fructose consumption has been attributed to the increase in the global prevalence of metabolic syndrome (MetS) and the development of oxidative stress. Oleanolic acid (OA) has anti-diabetic and anti-obesity effects. Read More

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http://dx.doi.org/10.3390/molecules24040661DOI Listing
February 2019

Optimisation of Protein Extraction from Medicinal Cannabis Mature Buds for Bottom-Up Proteomics.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Agriculture Victoria Research, AgriBio, Centre for AgriBioscience, Bundoora, Victoria 3083, Australia.

Medicinal cannabis is used to relieve the symptoms of certain medical conditions, such as epilepsy. Cannabis is a controlled substance and until recently was illegal in many jurisdictions. Consequently, the study of this plant has been restricted. Read More

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http://dx.doi.org/10.3390/molecules24040659DOI Listing
February 2019

Graphene-Based Nanocomposites for Neural Tissue Engineering.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon 999077, Hong Kong, China.

Graphene has made significant contributions to neural tissue engineering due to its electrical conductivity, biocompatibility, mechanical strength, and high surface area. However, it demonstrates a lack of biological and chemical cues. Also, it may cause potential damage to the host body, limiting its achievement of efficient construction of neural tissues. Read More

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http://dx.doi.org/10.3390/molecules24040658DOI Listing
February 2019

Efficient Synthesis of UDP-Furanoses via 4,5-Dicyanoimidazole(DCI)-Promoted Coupling of Furanosyl-1-Phosphates with Uridine Phosphoropiperidate.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, 605 Fenglin Avenue, Nanchang 330013, China.

A P(V)-N activation method based on nucleoside phosphoropiperidate/DCI system has been developed for improved synthesis of diverse UDP-furanoses. The reaction conditions including temperature, amount of activator, and reaction time were optimized to alleviate the degradation of UDP-furanoses to cyclic phosphates. In addition, an efficient and facile phosphoramidite route was employed for the preparation of furanosyl-1-phosphates. Read More

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http://dx.doi.org/10.3390/molecules24040655DOI Listing
February 2019

Active Components, Antioxidant, Inhibition on Metabolic Syndrome Related Enzymes, and Monthly Variations in Mature Leaf Hawk Tea.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.

Hawk tea is a rich and edible resource, traditionally used as a beverage in South China. This drink has many pharmacologic effects, such as acting as an antioxidant and reducing blood sugar and lipids. The objective of this work was to explore the active compound contents, bioactivities and their monthly changes, and optimize the harvest time. Read More

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http://dx.doi.org/10.3390/molecules24040657DOI Listing
February 2019

High Sensitive Immunoelectrochemical Measurement of Lung Cancer Tumor Marker ProGRP Based on TiO₂-Au Nanocomposite.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

School of Basic Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou 450002, Henan, China.

Progastrin-releasing peptide (ProGRP), which is known to be highly specific and sensitive to small cell lung cancer (SCLC), has been proven to be a valuable substitute for neuron-specific enolase in SCLC diagnostics and monitoring, especially in its early stages. The detection of ProGRP levels also facilitates a selection of therapeutic treatments. For the fabrication of our proposed biosensor, titanium (IV) oxide microparticles were first used, followed by dispersing gold nanoparticles into chitosan and immobilizing them onto a carbon paste electrode (CPE) surface. Read More

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http://dx.doi.org/10.3390/molecules24040656DOI Listing
February 2019

DesMol2, an Effective Tool for the Construction of Molecular Libraries and Its Application to QSAR Using Molecular Topology.

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

Molecular Topology and Drug Design Unit, Department of Physical Chemistry, University of Valencia, Avenida V.A. Estelles s/n, Burjassot, 46100 Valencia, Spain.

A web application, DesMol2, which offers two main functionalities, is presented: the construction of molecular libraries and the calculation of topological indices. These functionalities are explained through a practical example of research of active molecules to the formylpeptide receptor (FPR), a receptor associated with chronic inflammation in systemic amyloidosis and Alzheimer's disease. Starting from a data(base) of 106 dioxopiperazine pyrrolidin piperazine derivatives and their respective constant values of binding affinity to FPR, multilinear regression and discriminant analyses are performed to calculate several predictive topological-mathematical models. Read More

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http://dx.doi.org/10.3390/molecules24040736DOI Listing
February 2019

New Metabolic Influencer on Oxytocin Release: The Ghrelin.

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary.

Background: The hypothalamic⁻pituitary axis by secreting neuropeptides plays a key role in metabolic homeostasis. In light of the metabolic regulation, oxytocin is a potential neuropeptide for therapies against obesity and related disorders. The aim of our study is to measure ghrelin-induced oxytocin secretion in rats and to detect the changes after administration of ghrelin antagonist. Read More

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http://dx.doi.org/10.3390/molecules24040735DOI Listing
February 2019

Multicharged Phthalocyanines as Selective Ligands for G-Quadruplex DNA Structures.

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

QOPNA & LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.

The stabilization of G-Quadruplex DNA structures by ligands is a promising strategy for telomerase inhibition in cancer therapy since this enzyme is responsible for the unlimited proliferation of cancer cells. To assess the potential of a compound as a telomerase inhibitor, selectivity for quadruplex over duplex DNA is a fundamental attribute, as the drug must be able to recognize quadruplex DNA in the presence of a large amount of duplex DNA, in the cellular nucleus. By using different spectroscopic techniques, such as ultraviolet-visible, fluorescence and circular dichroism, this work evaluates the potential of a series of multicharged phthalocyanines, bearing four or eight positive charges, as G-Quadruplex stabilizing ligands. Read More

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http://dx.doi.org/10.3390/molecules24040733DOI Listing
February 2019

Yifei Tongluo, a Chinese Herbal Formula, Suppresses Tumor Growth and Metastasis and Exerts Immunomodulatory Effect in Lewis Lung Carcinoma Mice.

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, Shandong, China.

This study was aimed to investigate the anti-tumor, anti-metastasis and immunomodulatory effects of Yifei Tongluo (YFTL), a Chinese herbal formula, in Lewis lung carcinoma mice and to explore the underlying mechanisms. LLC cells were inoculated subcutaneously in C57BL/6 mice to establish the Lewis lung carcinoma model. We observed that YFTL effectively inhibited tumor growth and prolonged the overall survival of tumor-bearing mice. Read More

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http://dx.doi.org/10.3390/molecules24040731DOI Listing
February 2019

Potential of Zerumbone as an Anti-Cancer Agent.

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

Cancer Biology Laboratory, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences & Bioengineering, Indian Institute of Technology, Guwahati, Assam 781039, India.

Cancer is still a major risk factor to public health globally, causing approximately 9.8 million deaths worldwide in 2018. Despite advances in conventional treatment modalities for cancer treatment, there are still few effective therapies available due to the lack of selectivity, adverse side effects, non-specific toxicities, and tumour recurrence. Read More

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http://dx.doi.org/10.3390/molecules24040734DOI Listing
February 2019

Review of Ethnomedicinal, Phytochemical and Pharmacological Properties of (Engl.) Engl.

Authors:
Alfred Maroyi

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

Medicinal Plants and Economic Development (MPED) Research Centre, Department of Botany, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.

is a valuable medicinal plant species among different ethnic groups in tropical Africa. The aim of the current study was to review existing literature on the ethnomedicinal uses, phytochemistry and pharmacological properties of in an effort to evaluate the therapeutic potential of the species. The relevant information on the ethnomedicinal uses, phytochemistry and pharmacological properties of was generated from several sources including books, book chapters, theses, scientific reports and journal articles obtained from the library and internet sources such as SciFinder, Wiley, Web of Science, American Chemical Society publications, PubMed, BMC, Elsevier, Science Direct, Scielo and Scopus. Read More

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http://dx.doi.org/10.3390/molecules24040732DOI Listing
February 2019

Correlated Electronic Properties of a Graphene Nanoflake: Coronene.

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560012, India.

We report studies of the correlated excited states of coronene and substituted coronene within the Pariser⁻Parr⁻Pople (PPP) correlated π -electron model employing the symmetry-adapted density matrix renormalization group technique. These polynuclear aromatic hydrocarbons can be considered as graphene nanoflakes. We review their electronic structures utilizing a new symmetry adaptation scheme that exploits electron-hole symmetry, spin-inversion symmetry, and end-to-end interchange symmetry. Read More

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http://dx.doi.org/10.3390/molecules24040730DOI Listing
February 2019

Ingredients in Zijuan Pu'er Tea Extract Alleviate β-Amyloid Peptide Toxicity in a Model of Alzheimer's Disease Likely through DAF-16.

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.

Amyloid-β, one of the hallmarks of Alzheimer's disease (AD), is toxic to neurons and can also cause brain cell death. Oxidative stress is known to play an important role in AD, and there is strong evidence that oxidative stress is associated with amyloid-β. In the present study we report the protective effect of Zijuan Pu'er tea water extract (ZTWE) and the mixture of main ingredients (+)-catechins, caffeine and procyanidin (MCCP) in ZTWE on β-amyloid-induced toxicity in transgenic () CL4176 expressing the human Aβ gene. Read More

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http://dx.doi.org/10.3390/molecules24040729DOI Listing
February 2019
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A Novel Dantrolene Sodium-Loaded Mixed Micelle Containing a Small Amount of Cremophor EL: Characterization, Stability, Safety and Pharmacokinetics.

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines & Beijing Key laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Dantrolene sodium (DS) is the only drug specifically used for the treatment of malignant hyperthermia. Nevertheless, its clinical application is significantly restricted due to its aqueous insolubility and the limited formulations available in clinical practice. In order to solve these problems, a novel mixed micelle composed of phospholipid and Cremophor EL was designed and evaluated. Read More

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http://dx.doi.org/10.3390/molecules24040728DOI Listing
February 2019

Physicochemical Properties and Cellular Uptake of Astaxanthin-Loaded Emulsions.

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

Department of Food Science, Northeast Agriculture University, Harbin 150030, China.

Astaxanthin, a natural pigment carotenoid, is well known for its potential benefits to human health. However, its applications in the food industry are limited, due to its poor water-solubility and chemical instability. Six different emulsifiers were used to prepare astaxanthin-loaded emulsions, including whey protein isolate (WPI), polymerized whey protein (PWP), WPI-lecithin, PWP-lecithin, lecithin, and Tween20. Read More

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http://dx.doi.org/10.3390/molecules24040727DOI Listing
February 2019

Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions.

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

Dipartimento di Scienza e Alta Tecnologia, Università degli Studi Dell'Insubria, Via Valleggio 11, 22100 Como, Italy.

Trifluoromethylselenolated carbonyl compounds represent an emerging class with potential applications in several fields; however, a widespread use of such compound is hampered by the very limited number of strategies for their preparation. In this study we developed a method for the preparation of α-SeCF₃ substituted carbonyl derivatives using an in situ generated electrophilic ClSeCF₃ species. We also implemented an in-flow protocol to improve the safety features of the process. Read More

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http://dx.doi.org/10.3390/molecules24040726DOI Listing
February 2019

Antihyperlipidemic Effect, Identification and Isolation of the Lipophilic Components from Artemisia integrifolia.

Molecules 2019 Feb 17;24(4). Epub 2019 Feb 17.

College of Traditional Mongolian Medicine, Inner Mongolia Uaniversity for Nationalities, Tongliao 028000, China.

L (Compositae) is a medicinal and edible plant. To investigate its antihyperlipidemic effect, a crude lipophilic extract and the composing compounds were isolated and fractioned from the petroleum ether extract of aerial parts of using column chromatography on silica gel. The anti-hyperlipidemia effect was studied in a rat model of acute hyperlipidemia, which was induced by triton WR-1339. Read More

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http://dx.doi.org/10.3390/molecules24040725DOI Listing
February 2019

Preparation and Characterization of TiO₂-PVDF/PMMA Blend Membranes Using an Alternative Non-Toxic Solvent for UF/MF and Photocatalytic Application.

Molecules 2019 Feb 17;24(4). Epub 2019 Feb 17.

Institute on Membrane Technology (ITM-CNR), Via P. Bucci 17c, 87036 Rende (CS), Italy.

The approach of the present work is based on the use of poly (methylmethacrylate) (PMMA) polymer, which is compatible with PVDF and TiO₂ nanoparticles in casting solutions, for the preparation of nano-composites membranes using a safer and more compatible solvent. TiO₂ embedded poly (vinylidene fluoride) (PVDF)/PMMA photocatalytic membranes were prepared by phase inversion method. A non-solvent induced phase separation (NIPS) coupled with vapor induced phase separation (VIPS) was used to fabricate flat-sheet membranes using a dope solution consisting of PMMA, PVDF, TiO₂, and triethyl phosphate (TEP) as an alternative non-toxic solvent. Read More

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http://dx.doi.org/10.3390/molecules24040724DOI Listing
February 2019

Microparticles of Lamivudine-Poly-ε-Caprolactone Conjugate for Drug Delivery via Internalization by Macrophages.

Molecules 2019 Feb 17;24(4). Epub 2019 Feb 17.

Department of Physical Chemistry, Pharmaceutical Faculty, Wroclaw Medical University, Borowska 211, Wroclaw 50-556, Poland.

The past decade may be considered as revolutionary in the research field focused on the physiological function of macrophages. Unknown subtypes of these cells involved in pathological mechanisms were described recently, and they are considered as potential drug delivery targets. The innate ability to internalize foreign bodies exhibited by macrophages can be employed as a therapeutic strategy. Read More

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http://dx.doi.org/10.3390/molecules24040723DOI Listing
February 2019

Molecular Docking Studies of Coumarins Isolated from Extracts and Essential Oils of Link as Potential Inhibitors for Alzheimer's Disease.

Molecules 2019 Feb 17;24(4). Epub 2019 Feb 17.

Department of Plant Physiology, Slovak Agricultural University in Nitra, 94976 Nitra, Slovak.

Coumarins and essential oils are the major components of the Apiaceae family and the genus. The present study reports anticholinesterase and antioxidant activities of extracts and essential oils from aerial parts, roots, flowers, fruits and coumarins-bergapten (); imperatorin (), pimpinellin () and umbelliferone ()-isolated of the roots from . The investigation by light and scanning electron microscopy of the structures of secretory canals found different chemical compositions in the various types of secretory canals which present in the aerial parts, fruits and flowers. Read More

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http://dx.doi.org/10.3390/molecules24040722DOI Listing
February 2019

Amylase and Xylanase from Edible Fungus : Production and Characterization.

Molecules 2019 Feb 17;24(4). Epub 2019 Feb 17.

Swedish Centre for Resource Recovery, University of Borås, SE-50190 Borås, Sweden.

Integrated enzyme production in the biorefinery can significantly reduce the cost of the entire process. The purpose of the present study is to evaluate the production of two hydrolyzing enzymes (amylase and xylanase) by an edible fungus used in the biorefinery, . The enzyme production was explored through submerged fermentation of synthetic media and a wheat-based waste stream (thin stillage and wheat bran). Read More

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http://dx.doi.org/10.3390/molecules24040721DOI Listing
February 2019

Echinacoside Isolated from Putatively Stimulates Growth Hormone Secretion via Activation of the Ghrelin Receptor.

Molecules 2019 Feb 17;24(4). Epub 2019 Feb 17.

Graduate Institute of Biotechnology, National Chung-Hsing University, Taichung 402, Taiwan.

species, the ginseng of the desert, has been recorded to possess many biological activities in traditional Chinese pharmacopoeia and has been used as an anti-aging medicine. Three phenylethanoid glycosides-echinacoside, tubuloside A, and acteoside-were detected in the water extract of (Schenk) R. Wight and the major constituent, echinacoside, was further purified. Read More

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http://dx.doi.org/10.3390/molecules24040720DOI Listing
February 2019

Rapid Green Synthesis and Characterization of Silver Nanoparticles Arbitrated by Curcumin in an Alkaline Medium.

Molecules 2019 Feb 16;24(4). Epub 2019 Feb 16.

Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia (UPM), Serdang 43400, Malaysia.

Green synthesis of silver nanoparticles is desirable practice. It is not only the required technique for industrial and biomedical purposes but also a promising research area. The aim of this study was to synthesize green curcumin silver nanoparticles (C-Ag NPs). Read More

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http://dx.doi.org/10.3390/molecules24040719DOI Listing
February 2019

Acylated Flavonoid Glycosides are the Main Pigments that Determine the Flower Colour of the Brazilian Native Tree (Cham.) Cogn.

Molecules 2019 Feb 16;24(4). Epub 2019 Feb 16.

Botany Department, Institute of Bioscience, University of São Paulo (USP), São Paulo 05508-060, Brazil.

(Cham.) Cogn. is a plant native to Brazil whose genus and family (Melastomataceae) are poorly studied with regards to its metabolite profile. Read More

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http://dx.doi.org/10.3390/molecules24040718DOI Listing
February 2019

Analysis of Metabolite Accumulation Related to Pod Color Variation of .

Molecules 2019 Feb 16;24(4). Epub 2019 Feb 16.

College of Life Sciences, Inner Mongolia Agricultural University, Inner Mongolia Key Laboratory of Plant Stress Physiology and Molecular Biology, Hohhot 010018, China.

, a leguminous shrub widely distributed in cold and arid regions, is rich in secondary metabolites and natural active substances, with high nutritional and medical values. It is interesting that the pods of often show different colors among individual plants. In this study, 10-, 20- and 30-day-old red and green pods of were used to identify and characterize important metabolites associated with pod color. Read More

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http://dx.doi.org/10.3390/molecules24040717DOI Listing
February 2019

Position-Selective Synthesis and Biological Evaluation of Four Isomeric A-Ring Amino Derivatives of the Alkaloid Luotonin A.

Molecules 2019 Feb 16;24(4). Epub 2019 Feb 16.

Department of Pharmaceutical Chemistry, University of Vienna, Althanstraße 14, A-1090 Vienna, Austria.

Following two orthogonal synthetic routes, a series of all four possible A-ring amino derivatives of the natural product Luotonin A (a known Topoisomerase I inhibitor) was synthesized. In both strategies, intramolecular cycloaddition reactions are the key step. The target compounds were obtained in good yields by mild catalytic transfer hydrogenation of the corresponding nitro precursors. Read More

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http://dx.doi.org/10.3390/molecules24040716DOI Listing
February 2019

Isolation, Characterisation, and Lipase Production of a Cold-Adapted Bacterial Strain sp. LSK25 Isolated from Signy Island, Antarctica.

Molecules 2019 Feb 16;24(4). Epub 2019 Feb 16.

Enzyme and Microbial Technology Research Center, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang Selangor 43400, Malaysia.

In recent years, studies on psychrophilic lipases have been an emerging area of research in the field of enzymology. This study focuses on bacterial strains isolated from anthropogenically-influenced soil samples collected around Signy Island Research Station (South Orkney Islands, maritime Antarctic). Limited information on lipase activities from bacteria isolated from Signy station is currently available. Read More

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http://dx.doi.org/10.3390/molecules24040715DOI Listing
February 2019

Identification of Phytoconstituents in (Burm. F.) Merr. Leaves by High Performance Liquid Chromatography Micro Time-of-Flight Mass Spectrometry.

Molecules 2019 Feb 16;24(4). Epub 2019 Feb 16.

Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore.

(Vitaceae) is a Southeast Asian medicinal plant. In this study, an ethyl acetate fraction of leaves was studied for its phytoconstituents using high-performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-microTOF-Q-MS/MS) analysis. A total of 31 compounds of different classes, including benzoic acid derivatives, phenolics, flavonoids, catechins, dihydrochalcones, coumarins, megastigmanes, and oxylipins were identified using LC-MS/MS. Read More

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http://dx.doi.org/10.3390/molecules24040714DOI Listing
February 2019

Screening of Suitable Ionic Liquids as Green Solvents for Extraction of Eicosapentaenoic Acid (EPA) from Microalgae Biomass Using COSMO-RS Model.

Molecules 2019 Feb 16;24(4). Epub 2019 Feb 16.

International Institute for Halal Research and Training (INHART), International Islamic University Malaysia, Gombak, Kuala Lumpur 50728, Malaysia.

Omega-3 poly unsaturated fatty acids (PUFA) particularly eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), have many health benefits including reducing the risk of cancer and cardiovascular disease. Recently, the use of ionic liquids (ILs) in lipid extraction from microalgae provides the potential to overcome common drawbacks, offers several other benefits. To date, very limited researches are available to focus on extracting microalgae lipid and PUFA in particular by using ILs. Read More

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http://dx.doi.org/10.3390/molecules24040713DOI Listing
February 2019

All Solid-State Poly (Vinyl Chloride) Membrane Potentiometric Sensor Integrated with Nano-Beads Imprinted Polymers for Sensitive and Rapid Detection of Bispyribac Herbicide as Organic Pollutant.

Molecules 2019 Feb 16;24(4). Epub 2019 Feb 16.

Chemistry Department, Faculty of Science, Ain Shams University, P.O. 11566 Cairo, Egypt.

All-solid-state potentiometric sensors were prepared by using polyaniline (PANI) as the solid contact material. A film of PANI (thickness approximately being 0.25 µm) was deposited on a solid substrate (carbon screen printed platform). Read More

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http://dx.doi.org/10.3390/molecules24040712DOI Listing
February 2019

Optimization of an Ultrasound-Assisted Extraction Condition for Flavonoid Compounds from Cocoa Shells () Using Response Surface Methodology.

Molecules 2019 Feb 16;24(4). Epub 2019 Feb 16.

Malaysia Cocoa Board, Cocoa Innovative and Technology Centre, Lot 12621 Nilai Industrial Area, 71800 Nilai, Negeri Sembilan, Malaysia.

This study investigates the ultrasound-assisted extraction of flavonoids from Malaysian cocoa shell extracts, and optimization using response surface methodology. There are three variables involved in this study, namely: ethanol concentration (70⁻90 / %), temperature (45⁻65 °C), and ultrasound irradiation time (30⁻60 min). All of the data were collected and analyzed for variance (ANOVA). Read More

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http://dx.doi.org/10.3390/molecules24040711DOI Listing
February 2019

Effect of α-Tocopherol on the Physicochemical Properties of Sturgeon Surimi during Frozen Storage.

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.

This study investigated the effects of α-tocopherol (α-TOH) on the physicochemical properties of sturgeon surimi during 16-week storage at -18 °C. An aliquot of 0.1% (/) of α-TOH was added into the surimi and subjected to frozen storage, and 8% of a conventional cryoprotectant (4% sorbitol and 4% sucrose, /) was used as a positive control. Read More

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http://dx.doi.org/10.3390/molecules24040710DOI Listing
February 2019

Nrf2⁻ARE Signaling Acts as Master Pathway for the Cellular Antioxidant Activity of Fisetin.

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

Xiangya School of Public Health, Central South University, Changsha 410128, China.

Fisetin, a dietary flavonoid, is reported to have cellular antioxidant activity with an unclear mechanism. In this study, we investigated the effect of fisetin on the nuclear factor, erythroid 2-like 2 (Nrf2) signaling pathway in HepG2 cells to explore the cellular antioxidant mechanism. Fisetin upregulated the mRNA expression of heme oxygenase-1 (HO-1), glutamate-cysteine ligase catalytic subunit (GCLC), glutamate-cysteine ligase modifier subunit (GCLM), and NAD(P)H quinone oxidoreductase-1 (NQO1), and induced the protein of HO-1 but had no significant effect on the protein of GCLC, GCLM and NQO1. Read More

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http://dx.doi.org/10.3390/molecules24040708DOI Listing
February 2019

A New Method for Simultaneous Determination of Phenolic Acids, Alkaloids and Limonoids in Phellodendri Amurensis Cortex.

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences and Peking Union Medical College, Beijing 100193, China.

Phellodendri Amurensis Cortex (PAC) is a well-known herbal medicine in China with complex components, but the previous research has mostly focused on its alkaloids analysis. For the first time, a simpler and more efficient method was proposed in this paper to simultaneously determine the content of three different kinds of compounds-phenolic acids, alkaloids and limonoids-in PAC. The phenolic acids included 3--feruloylquinic acid, 4--feruloylquinic acid and syringin. Read More

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http://dx.doi.org/10.3390/molecules24040709DOI Listing
February 2019

Phytochemical Profiling of (Cactaceae) Growing in Greenhouse Conditions Using Ultra-High-Performance Liquid Chromatography⁻Tandem Mass Spectrometry.

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad 940, 20131 Aguascalientes, Mexico.

Chromatographic separation combined with mass spectrometry is a powerful tool for the characterization of plant metabolites because of its high sensitivity and selectivity. In this work, the phytochemical profile of aerial and radicular parts of (Engelm.) Britton & Rose growing under greenhouse conditions was qualitatively investigated for the first time by means of modern ultra-high-performance liquid chromatography⁻tandem mass spectrometry (UHPLC-PDA-HESI-Orbitrap-MS/MS). Read More

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http://dx.doi.org/10.3390/molecules24040705DOI Listing
February 2019

Newly Synthesized Oxygenated Xanthones as Potential P-Glycoprotein Activators: , , and Studies.

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

UCIBIO-REQUIMTE, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.

P-glycoprotein (P-gp) plays a crucial role in the protection of susceptible organs, by significantly decreasing the absorption/distribution of harmful xenobiotics and, consequently, their toxicity. Therefore, P-gp has been proposed as a potential antidotal pathway, when activated and/or induced. Knowing that xanthones are known to interact with P-gp, the main goal was to study P-gp induction or/and activation by six new oxygenated xanthones (OX 1-6). Read More

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http://dx.doi.org/10.3390/molecules24040707DOI Listing
February 2019

Antifungal Activity against of 2,6-Dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone Derivatives.

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

Laboratorio de Micología, Facultad de Química y Biología, Universidad de Santiago de Chile, Avenida Libertador Bernardo O'Higgins 3363, Santiago 518000, Chile.

In this work the enzyme laccase from was used to synthetize 2,6-dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone derivatives. Ten products with different substitutions in the aromatic ring were synthetized and characterized using ¹H- and C-NMR and mass spectrometry. The 3,5-dichlorinated compound showed highest antifungal activity against the phytopathogen , while the -methoxylated compound had the lowest activity; however, the antifungal activity of the products was higher than the activity of the substrates of the reactions. Read More

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http://dx.doi.org/10.3390/molecules24040706DOI Listing
February 2019

In Vivo and In Vitro Antioxidant Activities of Methanol Extracts from Olive Leaves on .

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

College of Life Science, Sichuan Agricultural University, Ya'an 625014, China.

The aim of this study was to evaluate the antioxidant activities of extracts from olive leaves (EOL). The main contents of EOL were determined by colorimetric methods. The antioxidant activities were assessed by measuring the scavenging free radicals in vitro. Read More

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http://dx.doi.org/10.3390/molecules24040704DOI Listing
February 2019

Physicochemical and Microstructural Properties of Polymerized Whey Protein Encapsulated 3,3'-Diindolylmethane Nanoparticles.

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

College of Agriculture and Life Sciences, The University of Vermont, Burlington, VT 05405, USA.

The fat-soluble antioxidant 3,3'-diindolylmethane (DIM), is a natural phytochemical found in vegetables, such as cabbage, broccoli, and Brussels sprouts. The stability of this compound is a major challenge for its applications. Polymerized whey protein (PWP)-based DIM nanoparticles were prepared at different mass ratios of protein and DIM by mixing PWP and DIM followed by ultrasound treatment for 4 min. Read More

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http://dx.doi.org/10.3390/molecules24040702DOI Listing
February 2019

Effect of Steaming Processing on Phenolic Profiles and Cellular Antioxidant Activities of .

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.

The intention of this study was to investigate the effect of steaming processing on phenolic profiles and antioxidant activities in chestnuts. Steaming processing at different times and temperatures depicted diverse impacts on free and bound fractions. Though, bound phenolics were stable but long time steaming at higher temperatures tended to improve the levels of phenolics, flavonoids as well as antioxidant activities in chestnut kernels, by up to 60. Read More

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http://dx.doi.org/10.3390/molecules24040703DOI Listing
February 2019

Antifungal, Antibacterial, and Antioxidant Activities of (Labill.) H. L. Wendl. Flower Extract: HPLC Analysis of Phenolic and Flavonoid Compounds.

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, 50000 Estado de México, Mexico.

In this study, for the environmental development, the antifungal, antibacterial, and antioxidant activities of a water extract of flowers from (Labill.) H. L. Read More

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http://dx.doi.org/10.3390/molecules24040700DOI Listing
February 2019

Trends in the Design of New Isobaric Labeling Reagents for Quantitative Proteomics.

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, 50-383 Wrocław, Poland.

Modern mass spectrometry is one of the most frequently used methods of quantitative proteomics, enabling determination of the amount of peptides in a sample. Although mass spectrometry is not inherently a quantitative method due to differences in the ionization efficiency of various analytes, the application of isotope-coded labeling allows relative quantification of proteins and proteins. Over the past decade, a new method for derivatization of tryptic peptides using isobaric labels has been proposed. Read More

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http://dx.doi.org/10.3390/molecules24040701DOI Listing
February 2019
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