16,232 results match your criteria Molecules [Journal]


Magnetically Assisted Control of Stem Cells Applied in 2D, 3D and In Situ Models of Cell Migration.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Wolfson STEM Centre, School of Medicine, The University of Nottingham, Nottingham NG7 2RD, UK.

The success of cell therapy approaches is greatly dependent on the ability to precisely deliver and monitor transplanted stem cell grafts at treated sites. Iron oxide particles, traditionally used in vivo for magnetic resonance imaging (MRI), have been shown to also represent a safe and efficient in vitro labelling agent for mesenchymal stem cells (MSCs). Here, stem cells were labelled with magnetic particles, and their resulting response to magnetic forces was studied using 2D and 3D models. Read More

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https://www.mdpi.com/1420-3049/24/8/1563
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http://dx.doi.org/10.3390/molecules24081563DOI Listing
April 2019
1 Read

Labdane and Abietane Diterpenoids from and Their Cytotoxic Activity.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University,Tianjin 30072, China.

A phytochemical investigation of the whole plant of led to the isolationof one previously undescribed labdane diterpenoid, (4,5,9,10)-13-des-ethyl-13-oxolabda-8(17),11-dien-19-oic acid (), together with nine known diterpenoids (-, -), two lignans (, ),and a coumarin (). The structures of all the compounds were elucidated on the basis ofspectrometric data, primarily one-dimensional (1D)- and two-dimensional (2D)-NMR and massspectrometry. Electronic circular dichroism (ECD) calculations determined the absoluteconfiguration of . Read More

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http://dx.doi.org/10.3390/molecules24081561DOI Listing

The Physical Vapor Transport Method for Bulk AlN Crystal Growth.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.

In this report, the development of physical vapor transport (PVT) methods for bulk aluminum nitride (AlN) crystal growth is reviewed. Three modified PVT methods with different features including selected growth at a conical zone, freestanding growth on a perforated sheet, and nucleation control with an inverse temperature gradient are discussed and compared in terms of the size and quality of the bulk AlN crystals they can produce as well as the process complexity. The PVT method with an inverse temperature gradient is able to significantly reduce the nucleation rate and realize the dominant growth of only one bulk AlN single crystal, and thus grow centimeter-sized bulk AlN single crystals. Read More

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https://www.mdpi.com/1420-3049/24/8/1562
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http://dx.doi.org/10.3390/molecules24081562DOI Listing
April 2019
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DNA Damaging Effects, Oxidative Stress Responses and Cholinesterase Activity in Blood and Brain of Wistar Rats Exposed to Δ-Tetrahydrocannabinol.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Institute for Medical Research and Occupational Health, Zagreb HR-10001, Croatia.

Currently we are faced with an ever-growing use of Δ-tetrahydrocannabinol (THC) preparations, often used as supportive therapies for various malignancies and neurological disorders. As some of illegally distributed forms of such preparations, like cannabis oils and butane hash oil, might contain over 80% of THC, their consumers can become intoxicated or experience various detrimental effects. This fact motivated us for the assessments of THC toxicity in vivo on a Wistar rat model, at a daily oral dose of 7 mg/kg which is comparable to those found in illicit preparations. Read More

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http://dx.doi.org/10.3390/molecules24081560DOI Listing

Studies Towards Hypoxia-Activated Prodrugs of PARP Inhibitors.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Auckland Cancer Society Research Centre, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1010, New Zealand.

Poly(ADP-ribose)polymerase (PARP) inhibitors (PARPi) have recently been approved for the treatment of breast and ovarian tumors with defects in homologous recombination repair (HRR). Although it has been demonstrated that PARPi also sensitize HRR competent tumors to cytotoxic chemotherapies or radiotherapy, normal cell toxicity has remained an obstacle to their use in this context. Hypoxia-activated prodrugs (HAPs) provide a means to limit exposure of normal cells to active drug, thus adding a layer of tumor selectivity. Read More

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http://dx.doi.org/10.3390/molecules24081559DOI Listing

The Effects of Mono-(2-Ethylhexyl) Phthalate (MEHP) on Human Estrogen Receptor (hER) and Androgen Receptor (hAR) by YES/YAS In Vitro Assay.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Environmental Safety Group, Korea Institute of Science and Technology (KIST⁻Europe), 66123 Saarbrucken, Germany.

Endocrine active compounds with structural similarities to natural hormones such as 17β-estradiol (E2) and androgen are suspected to affect the human endocrine system by inducing hormone-dependent effects. This study aimed to detect the (anti-)estrogenic and (anti-)androgenic activities of mono-(2-ethylhexyl) phthalate (MEHP) by yeast estrogen/androgen bioassay (YES/YAS). In addition, the mechanism and uptake of MEHP to receptors during agonistic and antagonistic activities were investigated through the activation signal recovery test and chromatographic analysis using liquid chromatography and tandem mass spectrometry (LC-MS/MS). Read More

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https://www.mdpi.com/1420-3049/24/8/1558
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http://dx.doi.org/10.3390/molecules24081558DOI Listing
April 2019
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Future Prospects in the Treatment of Parasitic Diseases: 2-Amino-1,3,4-Thiadiazoles in Leishmaniasis.

Authors:
Georgeta Serban

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Pharmaceutical Chemistry Department, Faculty of Medicine and Pharmacy, University of Oradea, 29 Nicolae Jiga, 410028 Oradea, Romania.

Neglected tropical diseases affect the lives of a billion people worldwide. Among them, the parasitic infections caused by protozoan parasites of the family have a huge impact on human health. Leishmaniasis, caused by spp. Read More

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http://dx.doi.org/10.3390/molecules24081557DOI Listing

Adlay ( L. var. Stapf.) Hull Extract and Active Compounds Inhibit Proliferation of Primary Human Leiomyoma Cells and Protect against Sexual Hormone-Induced Mice Smooth Muscle Hyperproliferation.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan.

Uterine leiomyomas, also known as fibroids, are benign neoplasms of the uterus and have a high incidence rate in women of reproductive age. Hysterectomy or myomectomy is the initial treatment, but fibroids will recur if the patient is still exposed to similar risk factors. Therefore, developing new therapeutic strategies are urgently necessary. Read More

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http://dx.doi.org/10.3390/molecules24081556DOI Listing

Using Extra Virgin Olive Oil to Cook Vegetables Enhances Polyphenol and Carotenoid Extractability: A Study Applying the Technique.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Department of Nutrition, Food Sciences and Gastronomy, XaRTA, INSA-UB, School of Pharmacy and Food Sciences, University of Barcelona, Carrer Prat de la Riba, 171, 08921 Santa Coloma de Gramenet, Spain.

Olive oil is the main source of fat in the Mediterranean diet and the most frequently used ingredient in Mediterranean cuisine. Cooking with olive oil has been attracting attention because it can act as a food excipient, thereby increasing the bioaccessibility and bioavailability of ingested bioactive compounds. The aim of this study was to understand the effect of cooking with olive oil on the bioactive components in other ingredients (tomato, onion, and garlic) of sauce, a representative model of Mediterranean cuisine. Read More

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http://dx.doi.org/10.3390/molecules24081555DOI Listing

Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from : A Review.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

is a medicinal plant species of the genus Aloe with a long history of usage around the world. Acemannan, considered one of the main bioactive polysaccharides of , possesses immunoregulation, anti-cancer, anti-oxidation, wound healing and bone proliferation promotion, neuroprotection, and intestinal health promotion activities, among others. In this review, recent advancements in the extraction, purification, structural characteristics and biological activities of acemannan from were summarized. Read More

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https://www.mdpi.com/1420-3049/24/8/1554
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http://dx.doi.org/10.3390/molecules24081554DOI Listing
April 2019
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Activation and Disproportionation of ZrFe Alloy as Hydrogen Storage Material.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Energy Materials and Technology Research Institute, General Research Institute for Nonferrous Metals, Beijing 100088, China.

As a hydrogen storage material, ZrFe alloy has many advantages such as fast hydrogen absorption speed, high tritium recovery efficiency, strong anti-pulverization ability, and difficulty self-igniting in air. ZrFe alloy has lower hydrogen absorption pressure at room temperature than LaNi alloy. Compared with the ZrVFe alloy, the hydrogen release temperature of ZrFe is lower so that the material can recover hydrogen isotopes at lower hydrogen concentration efficiently. Read More

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http://dx.doi.org/10.3390/molecules24081542DOI Listing

Synthesis and In Vitro Antibacterial Activity of Quaternized 10-Methoxycanthin-6-one Derivatives.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

College of Chemistry and Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi, China.

Background: Based on our previous work, we found that 10-methoxycanthin-6-one displayed potential antibacterial activity and quaternization was an available method for increasing the antibacterial activity. Here, we explored the antibacterial activity of quaternized 10-methoxy canthin-6-one derivatives.

Methods And Results: Twenty-two new 3--benzylated 10-methoxy canthin-6-ones were designed and synthesized through quaternization reaction. Read More

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http://dx.doi.org/10.3390/molecules24081553DOI Listing

Antiviral Activities of Silymarin and Derivatives.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.

Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. Recent studies have also documented the antiviral activities of silymarin and its derivatives against several viruses, including the flaviviruses (hepatitis C virus and dengue virus), togaviruses (Chikungunya virus and Mayaro virus), influenza virus, human immunodeficiency virus, and hepatitis B virus. This review will describe some of the latest preclinical and clinical studies detailing the antiviral profiles of silymarin and its derivatives, and discuss their relevance for antiviral drug development. Read More

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http://dx.doi.org/10.3390/molecules24081552DOI Listing

Comparative Study of Phenolic Profiles, Antioxidant and Antiproliferative Activities in Different Vegetative Parts of Ramie ( L.).

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Department of Food Science, Stocking Hall, Cornell University, Ithaca, NY 14853, USA.

Ramie ( L.) is usually cultivated as a fiber crop, but it is also well known for its potential use in animal feeding with viable commercial applications. In this study, the phenolics profile as well as cellular antioxidant and antiproliferative activities were investigated in free and bound fractions of six different vegetative parts from L. Read More

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http://dx.doi.org/10.3390/molecules24081551DOI Listing

Silibinin Downregulates the NF-κB Pathway and NLRP1/NLRP3 Inflammasomes in Monocytes from Pregnant Women with Preeclampsia.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Institute of Biosciences of Botucatu, Sao Paulo State University, UNESP, Botucatu 18618-691, Sao Paulo, Brazil.

Preeclampsia (PE) is a human pregnancy-specific syndrome with abnormal activation of cells from the innate immune system. The present study evaluated whether silibinin (SB) treatment of monocytes from preeclamptic women could modulate NLRP1 and NLRP3 inflammasomes as well as TLR4/NF-κB pathway activation. Peripheral blood monocytes from 20 preeclamptic and 20 normotensive (NT) pregnant women, as well as the THP-1 cell line, were cultured with or without monosodium urate (MSU) or SB. Read More

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http://dx.doi.org/10.3390/molecules24081548DOI Listing

Discrimination of Trichosanthis Fructus from Different Geographical Origins Using Near Infrared Spectroscopy Coupled with Chemometric Techniques.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Near infrared (NIR) spectroscopy with chemometric techniques was applied to discriminate the geographical origins of crude drugs (i.e., dried ripe fruits of ) and prepared slices of Trichosanthis Fructus in this work. Read More

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http://dx.doi.org/10.3390/molecules24081550DOI Listing

Diamond Nanoparticles Downregulate Expression of and in Glioma Cells.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Department of Veterinary and Animal Sciences, University of Copenhagen, Groennegaardsvej 3, 1870 Frederiksberg, Denmark.

Our previous studies have shown that diamond nanoparticles (NDs) exhibited antiangiogenic and proapoptotic properties in vitro in glioblastoma multiforme (GBM) cells and in tumors in vivo. Moreover, NDs inhibited adhesion, leading to the suppression of migration and invasion of GBM. In the present study, we hypothesized that the NDs might also inhibit proliferation and cell cycle in glioma cells. Read More

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http://dx.doi.org/10.3390/molecules24081549DOI Listing

A Water-Soluble Microencapsulated Milk Thistle Extract as Active Ingredient for Dermal Formulations.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (SA), Italy.

The choice of formulation is often of crucial importance in order to obtain a pharmaceutical product for the administration of poorly soluble drugs. Recently, a new water-soluble microparticulate powder form (MTE-mp) for the oral administration of a high functionality/low solubility silymarin rich milk thistle extract (MTE) has been developed. Findings showed that extract-loaded microparticles by spray-drying were produced with high and reproducible yields and encapsulation efficiency. Read More

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http://dx.doi.org/10.3390/molecules24081547DOI Listing

The Anti-Inflammatory Role of Mannich Curcuminoids; Special Focus on Colitis.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Laboratory of Functional Genomics, Biological Research Centre, Hungarian Academy of Sciences, Temesvári krt. 62, H-6726 Szeged, Hungary.

The incidence of inflammatory bowel disease (IBD) increases gradually in Western countries with high need for novel therapeutic interventions. Mannich curcuminoids, C142 or C150 synthetized in our laboratory, have been tested for anti-inflammatory activity in a rat model of TNBS (2,4,6-trinitrobenzenesulphonic acid) induced colitis. Treatment with C142 or C150 reduced leukocyte infiltration to the submucosa and muscular propria of the inflamed gut. Read More

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https://www.mdpi.com/1420-3049/24/8/1546
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http://dx.doi.org/10.3390/molecules24081546DOI Listing
April 2019
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How Humic Acids Affect the Rheological and Transport Properties of Hydrogels.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Materials Research Centre, Faculty of Chemistry, Brno University of Technology, Purkynova 118/464, 612 00 Brno, Czech Republic.

Humic acids are often regarded as substances with a supramolecular structure which plays an important role in Nature. Their addition into hydrogels can affect their behavior and functioning in different applications. This work is focused on the properties of widely-used hydrogel based on agarose after addition of humic acids-the protonated H-form of humic acids and humic acids with methylated carboxylic groups. Read More

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http://dx.doi.org/10.3390/molecules24081545DOI Listing

Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

DiSIT-Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale, Piazza Sant'Eusebio 5, 13100 Vercelli, Italy.

Propolis is the generic name of a complex of resinous compound collected by honeybees and it has been utilized for many years in folk medicine. As other products generated by honeybees (such as royal jelly, pollen, honey), propolis has great therapeutic properties, but very little scientific information is available. Therefore, this study was aimed at exploring the potential wound healing properties of propolis. Read More

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http://dx.doi.org/10.3390/molecules24081544DOI Listing

Antioxidant Properties of Four Commonly Consumed Popular Italian Dishes.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

CREA Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy.

Four popular dishes belonging to Italian cuisine and widely consumed in the country were experimentally prepared in a dedicated lab-kitchen following a validated and standardized protocol. This study provides their antioxidant properties evaluating the contribution of extractable and non-extractable bioactive compounds, and identifying the assessment of interactions between their natural active compounds and the food matrix. Ferric reducing antioxidant power (FRAP) values in aqueous-organic extract ranged from the highest antioxidant activity in (10. Read More

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http://dx.doi.org/10.3390/molecules24081543DOI Listing

Spiro Indane-Based Phosphine-Oxazolines as Highly Efficient P,N Ligands for Enantioselective Pd-Catalyzed Allylic Alkylation of Indoles and Allylic Etherification.

Molecules 2019 Apr 21;24(8). Epub 2019 Apr 21.

State Key laboratory Base of Eco-chemical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.

A series of indane-based phosphine-oxazoline ligands with a spirocarbon stereogenic center were examined for palladium-catalyzed asymmetric allylic alkylation of indoles. Under optimized conditions, high yields (up to 98%) and enantioselectivities (up to 98% ee) were obtained with a broad scope of indole derivatives. The ligand was determined to be the most efficient P,N-ligand for this reaction. Read More

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http://dx.doi.org/10.3390/molecules24081575DOI Listing

Ligand Selectivity in the Recognition of Protoberberine Alkaloids by Hybrid-2 Human Telomeric G-Quadruplex: Binding Free Energy Calculation, Fluorescence Binding, and NMR Experiments.

Molecules 2019 Apr 21;24(8). Epub 2019 Apr 21.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.

The human telomeric G-quadruplex (G4) is an attractive target for developing anticancer drugs. Natural products protoberberine alkaloids are known to bind human telomeric G4 and inhibit telomerase. Among several structurally similar protoberberine alkaloids, epiberberine (EPI) shows the greatest specificity in recognizing the human telomeric G4 over duplex DNA and other G4s. Read More

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http://dx.doi.org/10.3390/molecules24081574DOI Listing

Antibacterial Activity of Different Blossom Honeys: New Findings.

Molecules 2019 Apr 21;24(8). Epub 2019 Apr 21.

Laboratory of Apidology and Apitherapy, Department of Microbial Genetics, Institute of Molecular Biology, Slovak Academy of Sciences, Dubravska cesta 21, 845 51 Bratislava, Slovakia.

Antibacterial activity is the most investigated biological property of honey. The goal of this study was to evaluate the antibacterial activity of 57 Slovak blossom honeys against and and investigate the role of several bioactive substances in antibacterial action of honeys. Inhibitory and bactericidal activities of honeys were studied to determine the minimum inhibitory and bactericidal concentrations. Read More

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http://dx.doi.org/10.3390/molecules24081573DOI Listing

Analyzing Secondary Structure Patterns in DNA Aptamers Identified via CompELS.

Molecules 2019 Apr 21;24(8). Epub 2019 Apr 21.

School of Materials Science and Engineering, Georgia Institute of Technology, 771 Ferst Dr. NW, Atlanta, GA 30332-0245, USA.

In contrast to sophisticated high-throughput sequencing tools for genomic DNA, analytical tools for comparing secondary structure features between multiple single-stranded DNA sequences are less developed. For single-stranded nucleic acid ligands called aptamers, secondary structure is widely thought to play a pivotal role in driving recognition-based binding activity between an aptamer sequence and its specific target. Here, we employ a competition-based aptamer screening platform called CompELS to identify DNA aptamers for a colloidal target. Read More

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http://dx.doi.org/10.3390/molecules24081572DOI Listing

Modelling Contaminant Formation during Thermal Processing of Sea Buckthorn Purée.

Molecules 2019 Apr 20;24(8). Epub 2019 Apr 20.

Integrated Center for Research, Expertise and Technological Transfer in Food Industry, Faculty of Food Science and Engineering, Dunarea de Jos University of Galati, 111 Domnească Street, 800201 Galati, Romania.

: The impact of thermal treatment on acrylamide (ACR) and hydroxymethylfurfural (HMF) formation was investigated for thermally treated sea buckthorn purée. : An optimized procedure for minimizing ACR and HMF formation in thermally treated sea buckthorn purée was described. The precursors of ACR and HMF and their impact in heating of sea buckthorn purée to obtain jam-like products were also evaluated. Read More

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https://www.mdpi.com/1420-3049/24/8/1571
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http://dx.doi.org/10.3390/molecules24081571DOI Listing
April 2019
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Impact of Small Molecules on Intermolecular G-Quadruplex Formation.

Molecules 2019 Apr 20;24(8). Epub 2019 Apr 20.

Department of Physics, Kent State University, Kent, OH 44242, USA.

We performed single molecule studies to investigate the impact of several prominent small molecules (the oxazole telomestatin derivative L2H2-6OTD, pyridostatin, and Phen-DC) on intermolecular G-quadruplex (i-GQ) formation between two guanine-rich DNA strands that had 3-GGG repeats in one strand and 1-GGG repeat in the other (3+1 GGG), or 2-GGG repeats in each strand (2+2 GGG). Such structures are not only physiologically significant but have recently found use in various biotechnology applications, ranging from DNA-based wires to chemical sensors. Understanding the extent of stability imparted by small molecules on i-GQ structures, has implications for these applications. Read More

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http://dx.doi.org/10.3390/molecules24081570DOI Listing
April 2019
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Copper-Catalyzed Regioselective Synthesis of ()-β-Fluorovinyl Sulfones.

Molecules 2019 Apr 20;24(8). Epub 2019 Apr 20.

Departamento de Química Orgánica, Universitat de València, 46100 Burjassot, Spain.

Organofluorine compounds are finding increasing application in a variety of fields such as pharmaceutical, agrochemical, and material sciences. However, given the scarcity of fluorine-containing natural products, advancement in this area depends almost entirely on the development of new synthetic methodologies. In this article, we present the synthesis of a series of previously undescribed ()-β-fluorovinyl sulfones via a simple copper-catalyzed addition of hydrogen fluoride to alkynyl sulfone starting materials in varying yields and selectivities. Read More

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http://dx.doi.org/10.3390/molecules24081569DOI Listing

Beer Molecules and Its Sensory and Biological Properties: A Review.

Molecules 2019 Apr 20;24(8). Epub 2019 Apr 20.

Biomaterials Laboratory (LBMat), Institute of Technology and Research (ITP), Av. Murilo Dantas, 300, Aracaju 49032-490, Sergipe, Brazil.

The production and consumption of beer plays a significant role in the social, political, and economic activities of many societies. During brewing fermentation step, many volatile and phenolic compounds are produced. They bring several organoleptic characteristics to beer and also provide an identity for regional producers. Read More

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http://dx.doi.org/10.3390/molecules24081568DOI Listing

A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A.

Molecules 2019 Apr 20;24(8). Epub 2019 Apr 20.

Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, 240 W. Green St, Athens, GA 30602, USA.

Kinases regulate multiple and diverse signaling pathways and misregulation is implicated in a multitude of diseases. Although significant efforts have been put forth to develop kinase-specific inhibitors, specificity remains a challenge. As an alternative to catalytic inhibition, allosteric inhibitors can target areas on the surface of an enzyme, thereby providing additional target diversity. Read More

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http://dx.doi.org/10.3390/molecules24081567DOI Listing

Probing the Effect of Bulky Lesion-Induced Replication Fork Conformational Heterogeneity Using 4-Aminobiphenyl-Modified DNA.

Molecules 2019 Apr 20;24(8). Epub 2019 Apr 20.

Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 7 Greenhouse Road, Kingston, RI 02881, USA.

Bulky organic carcinogens are activated in vivo and subsequently react with nucleobases of cellular DNA to produce adducts. Some of these DNA adducts exist in multiple conformations that are slowly interconverted to one another. Different conformations have been implicated in different mutagenic and repair outcomes. Read More

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http://dx.doi.org/10.3390/molecules24081566DOI Listing

Effect of Protein Conformation and AMP Protonation State on Fireflies' Bioluminescent Emission.

Molecules 2019 Apr 20;24(8). Epub 2019 Apr 20.

Laboratoire Modélisation et Simulation Multi Échelle, Université Paris-Est, MSME UMR 8208 CNRS, UPEM, 5 bd Descartes, 77454 Marne-la-Vallée, France.

The emitted color in fireflies' bioluminescent systems depends on the beetle species the system is extracted from and on different external factors (pH, temperature…) among others. Controlling the energy of the emitted light (i.e. Read More

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http://dx.doi.org/10.3390/molecules24081565DOI Listing

Development of a Green Downstream Process for the Valorization of Biomass.

Molecules 2019 Apr 20;24(8). Epub 2019 Apr 20.

Laboratory of Foodomics, Institute of Food Science Research (CIAL, CSIC-UAM), Calle Nicolás Cabrera 9, 28049 Madrid, Spain.

As the interest in biorefinery approaches is continuously increasing, new alternatives for the downstream valorization of biomasses are sought. microalga is a good natural source for a variety of interesting bioactive compounds, including carotenoids, phycoerythrin, and sulfated polysaccharides. In the present contribution, the use of compressed fluids-based techniques is explored towards the efficient and green extraction of bioactive compounds to valorize microalgal biomass. Read More

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https://www.mdpi.com/1420-3049/24/8/1564
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http://dx.doi.org/10.3390/molecules24081564DOI Listing
April 2019
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Recent Advances in the Discovery and Biosynthetic Study of Eukaryotic RiPP Natural Products.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.

Natural products have played indispensable roles in drug development and biomedical research. Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a group of fast-expanding natural products attribute to genome mining efforts in recent years. Most RiPP natural products were discovered from bacteria, yet many eukaryotic cyclic peptides turned out to be of RiPP origin. Read More

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https://www.mdpi.com/1420-3049/24/8/1541
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http://dx.doi.org/10.3390/molecules24081541DOI Listing
April 2019
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Preparation of Benzothiazolyl-Decorated Nanoliposomes.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Laboratory of Pharmaceutical Technology, Dept. of Pharmacy, School of Health Sciences, University of Patras, 26510 Rio, Greece.

Amyloid β (Aβ) species are considered as potential targets for the development of diagnostics/therapeutics towards Alzheimer's disease (AD). Nanoliposomes which are decorated with molecules having high affinity for Aβ species may be considered as potential carriers for AD theragnostics. Herein, benzothiazolyl (BTH) decorated nanoliposomes were prepared for the first time, after synthesis of a lipidic BTH derivative (lipid-BTH). Read More

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https://www.mdpi.com/1420-3049/24/8/1540
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http://dx.doi.org/10.3390/molecules24081540DOI Listing
April 2019
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Novel Carbon/PEDOT/PSS-Based Screen-Printed Biosensors for Acetylcholine Neurotransmitter and Acetylcholinesterase Detection in Human Serum.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Chemistry Department, Faculty of Science, Ain Shams University, P.O. Cairo 11566, Egypt.

New reliable and robust potentiometric ion-selective electrodes were fabricated using poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) as the solid contact between the sensing membrane and electrical substrate for an acetylcholine (ACh) bioassay. A film of PEDOT/PSS was deposited on a solid carbon screen-printed platform made from ceramic substrate. The selective materials used in the ion-selective electrode (ISE) sensor membrane were acetylcholinium tetraphenylborate (ACh/TPB/PEDOT/PSS-ISE) (sensor I) and triacetyl-β-cyclodextrin (β-CD/PEDOT/PSS-ISE) (sensor II). Read More

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https://www.mdpi.com/1420-3049/24/8/1539
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http://dx.doi.org/10.3390/molecules24081539DOI Listing
April 2019
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Shedding New Light on The Role of ανβ3 and α5β1 Integrins in Rheumatoid Arthritis.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

The Engineering Research Center of Synthetic Polypeptide Drug Discovery and Evaluation of Jiangsu Province, China Pharmaceutical University, Nanjing 210009, China.

ανβ3 and α5β1 are essential glycoproteins involved in the pathogenesis of rheumatoid arthritis (RA). Understanding of the role these integrins play in disease have been analyzed via description of cells-expressing ανβ3 and α5β1 and their mediators to trigger inflammation. ανβ3 and α5β1 facilitate cells-ECM and cell-cell communication, producing pro-inflammatory factors. Read More

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https://www.mdpi.com/1420-3049/24/8/1537
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http://dx.doi.org/10.3390/molecules24081537DOI Listing
April 2019
2 Reads

PEGylated Polyurea Bearing Hindered Urea Bond for Drug Delivery.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China.

In recent years, polyureas with dynamic hindered urea bonds (HUBs), a class of promising biomedical polymers, have attracted wide attention as a result of their controlled hydrolytic properties. The effect of the chemical structures on the properties of polyureas and their assemblies has rarely been reported. In this study, four kinds of polyureas with different chemical groups have been synthesized, and the polyureas from cyclohexyl diisocyanate and tert-butyl diamine showed the fastest hydrolytic rate. Read More

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https://www.mdpi.com/1420-3049/24/8/1538
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http://dx.doi.org/10.3390/molecules24081538DOI Listing
April 2019
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Phytochemical Characterization of Five Edible Purple-Reddish Vegetables: Anthocyanins, Flavonoids, and Phenolic Acid Derivatives.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 3-5 Calea Manastur, Cluj-Napoca 400372, Romania.

Vegetables comprise a significant portion of our daily diet with their high content in nutrients including fiber, vitamins, minerals, as well as phenolic compounds. Vegetable consumption has been shown to be positively associated with the prevention of several degenerative diseases thanks to their bioactive compounds. Accordingly, five selected vegetables, namely, red chicory, red onion, eggplant, purple sweet potato, and black carrot were thoroughly assessed for their phenolic content in this study. Read More

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http://dx.doi.org/10.3390/molecules24081536DOI Listing

The Effect of Fulvic Acids Derived from Different Materials on Changing Properties of Albic Black Soil in the Northeast Plain of China.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agriculture Sciences, Beijing 100081, China.

Despite low fertility and content of organic carbon in albic black soil, grains are grown in this type of soil in the northeast plain of China in order to find ways to improve the soil's fertility and crop production. We carried out pot experiments of maize applied with one of three different treatments of fulvic acids (FA) derived from different parent materials: Plant-derived solid (PDSF), mineral-derived liquid (MDLF), and plant-derived liquid (PDLF) applied at respective rates of 2.5, 5, and 5 g kg as well as a control applied at 0 g kg. Read More

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https://www.mdpi.com/1420-3049/24/8/1535
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http://dx.doi.org/10.3390/molecules24081535DOI Listing
April 2019
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Preparation of Zirconium-89 Solutions for Radiopharmaceutical Purposes: Interrelation Between Formulation, Radiochemical Purity, Stability and Biodistribution.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Zhivopisnaya str., bld. 46; 123182 Moscow, Russia.

Zirconium-89 is a promising radionuclide for nuclear medicine. The aim of the present work was to find a suitable method for obtaining zirconium-89 solutions for radiopharmaceutical purposes. For this purpose, the ion exchange behavior of zirconium-89 solutions was studied. Read More

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http://dx.doi.org/10.3390/molecules24081534DOI Listing

Recent Advances on Metal-Free, Visible-Light- Induced Catalysis for Assembling Nitrogen- and Oxygen-Based Heterocyclic Scaffolds.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Institute of Organic Chemistry Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.

Heterocycles are important class of structures, which occupy a major space in the domain of natural and bioactive compounds. For this reason, development of new synthetic strategies for their controllable synthesis became of special interests. The development of novel photoredox systems with wide-range application in organic synthesis is particularly interesting. Read More

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http://dx.doi.org/10.3390/molecules24081533DOI Listing
April 2019
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Anionic Polymerization Using Flow Microreactors.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.

Flow microreactors are expected to make a revolutionary change in chemical synthesis involving various fields of polymer synthesis. In fact, extensive flow microreactor studies have opened up new possibilities in polymer chemistry including cationic polymerization, anionic polymerization, radical polymerization, coordination polymerization, polycondensation and ring-opening polymerization. This review provides an overview of flow microreactors in anionic polymerization and their various applications. Read More

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http://dx.doi.org/10.3390/molecules24081532DOI Listing

Determination of the [N]-Nitrate/[N]-Nitrate Ratio in Plant Feeding Studies by GC⁻MS.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Biotechnology of Horticultural Crops, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Liesel-Beckmann-Straße 1, 85354 Freising, Germany.

Feeding experiments with stable isotopes are helpful tools for investigation of metabolic fluxes and biochemical pathways. For assessing nitrogen metabolism, the heavier nitrogen isotope, [N], has been frequently used. In plants, it is usually applied in form of [N]-nitrate, which is assimilated mainly in leaves. Read More

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https://www.mdpi.com/1420-3049/24/8/1531
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http://dx.doi.org/10.3390/molecules24081531DOI Listing
April 2019
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Simultaneous Quantification of Five Sesquiterpene Components after Ultrasound Extraction in L. by an Accurate and Rapid UPLC⁻PDA Assay.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

School of Traditional Chinese Medicine, Capital Medical University, No.10, Xitoutiao, You'anmenwai, Fengtai District, Beijing 100069, China.

: To develop an accurate and rapid ultra-performance liquid chromatography (UPLC) coupled with a photodiode array (PDA) method for the simultaneous determination of artemisinin (Art), arteannuin B (Art B), arteannuin C (Art C), dihydroartemisinic acid (DHAA) and artemisinic acid (AA) in L. : Chromatography separation was performed on an ACQUITY UPLC BEH C18 Column with isocratic elution; the mobile phase was 0.1% formic acid aqueous solution (A) and acetonitrile (B) (A:B = 40:60, /). Read More

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http://dx.doi.org/10.3390/molecules24081530DOI Listing

Synthesis of New Derivatives of Benzofuran as Potential Anticancer Agents.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Łódź, Poland.

The results of our previous research indicated that some derivatives of benzofurans, particularly halogeno-derivatives, are selectively toxic towards human leukemia cells. Continuing our work with this group of compounds we here report new data on the synthesis as well as regarding the physico-chemical and biological characterization of fourteen new derivatives of benzofurans, including six brominated compounds. The structures of all new compounds were established by spectroscopic methods (H- and, C-NMR, ESI MS), and elemental analyses. Read More

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http://dx.doi.org/10.3390/molecules24081529DOI Listing

Synthesis of Chromen-4-One-Oxadiazole Substituted Analogs as Potent -Glucuronidase Inhibitors.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Chromen-4-one substituted oxadiazole analogs - have been synthesized, characterized and evaluated for -glucuronidase inhibition. All analogs exhibited a variable degree of -glucuronidase inhibitory activity with IC values ranging in between 0.8 ± 0. Read More

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https://www.mdpi.com/1420-3049/24/8/1528
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http://dx.doi.org/10.3390/molecules24081528DOI Listing
April 2019
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Baijiu Vinasse Extract Scavenges Glyoxal and Inhibits the Formation of -Carboxymethyllysine in Dairy Food.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China.

The inhibitory effects of baijiu vinasse extract and its phenolic acid compounds on the -carboxymethyllysine (CML) formation from dairy food were investigated. The inhibitory effect of the baijiu vinasse extract against CML formation was 43.2% in the casein and D-glucose model, which used 6 mL of the 70% acetone extract at 60 °C for 40 min. Read More

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https://www.mdpi.com/1420-3049/24/8/1526
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http://dx.doi.org/10.3390/molecules24081526DOI Listing
April 2019
2 Reads

High-Sensitivity Determination of Nutrient Elements in by Laser-induced Breakdown Spectroscopy and Chemometric Methods.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

College of Biosystems Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China.

High-accuracy and fast detection of nutritive elements in traditional Chinese medicine (PN) is beneficial for providing useful assessment of the healthy alimentation and pharmaceutical value of PN herbs. Laser-induced breakdown spectroscopy (LIBS) was applied for high-accuracy and fast quantitative detection of six nutritive elements in PN samples from eight producing areas. More than 20,000 LIBS spectral variables were obtained to show elemental differences in PN samples. Read More

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http://dx.doi.org/10.3390/molecules24081525DOI Listing