10,193 results match your criteria Molecular medicine reports[Journal]


Comprehensive analysis of differentially expressed profiles and reconstruction of a competing endogenous RNA network in papillary renal cell carcinoma.

Mol Med Rep 2019 Apr 5. Epub 2019 Apr 5.

Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Long noncoding RNAs (lncRNAs) function as competing endogenous RNAs (ceRNAs). ceRNA networks may serve important roles in various tumors, as demonstrated by an increasing number of studies; however, papillary renal cell carcinoma (PRCC)‑associated ceRNA networks mediated by lncRNAs remain unknown. Increased knowledge of ceRNA networks in PRCC may aid the identification of novel targets and biomarkers in the treatment of PRCC. Read More

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http://dx.doi.org/10.3892/mmr.2019.10138DOI Listing
April 2019
2 Reads

lncRNA 430945 promotes the proliferation and migration of vascular smooth muscle cells via the ROR2/RhoA signaling pathway in atherosclerosis.

Mol Med Rep 2019 Apr 5. Epub 2019 Apr 5.

Department of Cardiology, Tangshan Workers Hospital, Tangshan, Hebei 063000, P.R. China.

The proliferation and migration of vascular smooth muscle cells (VSMCs) are major cellular events in hypertension‑induced vascular remodeling, which is closely involved in the progression of atherosclerosis (AS). Although long non‑coding RNAs (lncRNAs) are gaining recognition as novel regulators of VSMCs, their functioning and role in AS remain to be elucidated. In the present study, the role of lncRNA ENST00000430945 (lncRNA 430945) in AS was investigated. Read More

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http://www.spandidos-publications.com/10.3892/mmr.2019.10137
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http://dx.doi.org/10.3892/mmr.2019.10137DOI Listing
April 2019
7 Reads
1.484 Impact Factor

Overexpression of CKS2 is associated with a poor prognosis and promotes cell proliferation and invasion in breast cancer.

Mol Med Rep 2019 Apr 5. Epub 2019 Apr 5.

Department of Breast and Thyroid Surgery, Ninghai First Hospital, Ninghai, Zhejiang 315600, P.R. China.

Growing evidence indicates that cyclin dependent kinases regulatory subunit 2 (CKS2) serves an essential role in the regulation of multiple cellular processes in diverse human cancer types. The present study investigated the contribution of CKS2 to breast cancer (BC) progression. In the present study, CKS2 expression in BC was detected using Oncomine and The Cancer Genome Atlas database. Read More

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http://www.spandidos-publications.com/10.3892/mmr.2019.10134
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http://dx.doi.org/10.3892/mmr.2019.10134DOI Listing
April 2019
2 Reads

Arbutin promotes MC3T3‑E1 mouse osteoblast precursor cell proliferation and differentiation via the Wnt/β‑catenin signaling pathway.

Mol Med Rep 2019 Apr 4. Epub 2019 Apr 4.

Department of Orthopedic Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110000, P.R. China.

Arbutin is a natural compound extracted from various plants, including bearberry leaves, that exerts multiple effects including skin whitening, anti‑inflammatory and oxidative stress‑protective properties. However, the effects of arbutin on osteoblasts remain unknown. The aim of the present study was to investigate the function and the mechanisms of arbutin on the proliferation and differentiation of MC3T3‑E1 mouse osteoblast precursor cells in vitro. Read More

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http://dx.doi.org/10.3892/mmr.2019.10125DOI Listing
April 2019
2 Reads

Low‑intensity pulsed ultrasound promotes apoptosis and inhibits angiogenesis via p38 signaling‑mediated endoplasmic reticulum stress in human endothelial cells.

Mol Med Rep 2019 Apr 5. Epub 2019 Apr 5.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.

Aberrant increase in angiogenesis contributes to the progression of malignant solid tumors. An alternative anti‑angiogenesis therapy is critical for cancer, since the current anti‑angiogenesis drugs lack specificity for tumor cells. In the present study, the effects and mechanisms of low‑intensity pulsed ultrasound (LIPUS) on human umbilical vein endothelial cells (HUVECs) and human microvascular endothelial cells (HMECs) were investigated, and the therapeutic potential of this technology was assessed. Read More

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http://dx.doi.org/10.3892/mmr.2019.10136DOI Listing
April 2019
1 Read

miR‑27b‑3p and miR‑607 cooperatively regulate BLM gene expression by directly targeting the 3'‑UTR in PC3 cells.

Mol Med Rep 2019 Apr 5. Epub 2019 Apr 5.

Key Laboratory of Animal Genetics, Breeding and Reproduction in The Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, Guizhou 550025, P.R. China.

BLM RecQ like helicase (BLM) has a pivotal role in genetic recombination, transcription, DNA replication and DNA repair, which presents the possibility of using BLM as an anti‑cancer target for treatment. However, the post‑transcriptional control regulation of BLM gene expression is not fully understood and limits the application of drugs targeting BLM for carcinoma therapy in the future. MicroRNAs (miRNAs) inhibit gene expression through interaction with the 3' untranslated region (3'‑UTR) of mRNA at the post‑transcriptional stage. Read More

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http://dx.doi.org/10.3892/mmr.2019.10135DOI Listing
April 2019
3 Reads

Paroxysmal spasticity of lower extremities as the initial symptom in two siblings with maple syrup urine disease.

Mol Med Rep 2019 Apr 5. Epub 2019 Apr 5.

Department of Pediatrics, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China.

Maple syrup urine disease (MSUD) is a rare autosomal recessive metabolic disorder caused by mutations in genes that encode subunits of the branched‑chain α‑ketoacid dehydrogenase (BCKD) complex. Impairment of the BCKD complex results in an abnormal accumulation of branched‑chain amino acids and their corresponding branched‑chain keto acids in the blood and cerebrospinal fluid, which are neurovirulent and may become life‑threatening. An 11‑day‑old boy was admitted to the hospital with paroxysmal spasticity of lower extremities. Read More

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http://dx.doi.org/10.3892/mmr.2019.10133DOI Listing
April 2019
2 Reads

Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA‑treated HepG2 cells.

Mol Med Rep 2019 Apr 5. Epub 2019 Apr 5.

Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, National and Local Joint Engineering Research Center of High‑throughput Drug Screening Technology, Hubei University, Wuhan, Hubei 430062, P.R. China.

Non‑alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, and has high rates of morbidity and mortality worldwide. Daphnetin (DAP) possesses notable antioxidative, anti‑inflammatory and anticoagulant activities; DAP is an active ingredient extracted from Daphne Koreana Nakai. To investigate the effects and the underlying mechanism of DAP on NAFLD, we treated HepG2 cells with oleic acid (OA) and DAP simultaneously and non‑simultaneously. Read More

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http://dx.doi.org/10.3892/mmr.2019.10139DOI Listing

Zinc finger E‑box binding homeobox 2 functions as an oncogene in human laryngeal squamous cell carcinoma.

Mol Med Rep 2019 Apr 4. Epub 2019 Apr 4.

Department of Biochemistry, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.

Zinc finger E‑box binding homeobox 2 (ZEB2) is a member of the Zfh1 family of two‑handed zinc finger/homeodomain proteins. To date, the role of ZEB2 in human laryngeal carcinoma has not been clearly defined. In the present study, the level of ZEB2 expression in laryngeal squamous cell carcinoma (LSCC) tissues and adjacent normal tissues was evaluated using reverse transcription‑quantitative polymerase chain reaction. Read More

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http://www.spandidos-publications.com/10.3892/mmr.2019.10126
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http://dx.doi.org/10.3892/mmr.2019.10126DOI Listing
April 2019
11 Reads

Exosomes derived from mangiferin‑stimulated perivascular adipose tissue ameliorate endothelial dysfunction.

Mol Med Rep 2019 Apr 4. Epub 2019 Apr 4.

Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China.

Perivascular adipose tissue (PVAT) is considered to serve a vital role during the development of endothelial dysfunction. The current study investigated the effect of exosomes derived from mangiferin‑stimulated PVAT on endothelial function, including regeneration, migration, apoptosis and inflammation. The number of exosomes secreted by PVAT was increased by stimulation with mangiferin (0. Read More

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http://dx.doi.org/10.3892/mmr.2019.10127DOI Listing
April 2019
1 Read

Role of lncRNA uc.457 in the differentiation and maturation of cardiomyocytes.

Mol Med Rep 2019 Apr 4. Epub 2019 Apr 4.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.

Congenital heart disease (CHD) is the most common type of birth defect, and the leading cause of fetal mortality. The long noncoding RNA (lncRNA) uc.457 is differentially expressed in cardiac tissue from patients with a ventricular septal defect; however, its role in cardiac development and CHD remains unknown. Read More

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http://dx.doi.org/10.3892/mmr.2019.10132DOI Listing
April 2019
3 Reads

miRNA‑15a‑5p facilitates the bone marrow stem cell apoptosis of femoral head necrosis through the Wnt/β‑catenin/PPARγ signaling pathway.

Mol Med Rep 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurosurgery, Hongqi Hospital Affiliated with Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China.

Bone marrow stem cells (BMSCs) are a group cells that function as an underlying cell source for bone tissue regeneration. However, the molecular mechanisms of how BMSCs are induced into apoptosis remains unclear. In the present study, it was demonstrated that the molecular mechanisms of BMSCs were exerted via microRNA‑15a‑5p (miR‑15a‑5p) in femoral head necrosis (FHN). Read More

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http://dx.doi.org/10.3892/mmr.2019.10130DOI Listing
April 2019
1 Read

Long noncoding RNA STCAT16 suppresses cell growth and its expression predicts prognosis in patients with gastric cancer.

Mol Med Rep 2019 Apr 4. Epub 2019 Apr 4.

Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China.

Gastric cancer (GC) is a leading cause of cancer‑associated mortality worldwide. Previous studies demonstrated that long noncoding RNAs (lncRNAs) may be dysregulated in GC and may serve important roles in cancer progression. The present study aimed to investigate the role of the novel lncRNA stomach cancer‑associated transcript 16 (STCAT16; Assembly Gene ID G038291) in the development and progression of GC. Read More

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http://dx.doi.org/10.3892/mmr.2019.10128DOI Listing

miR‑210‑3p regulates cell growth and affects cisplatin sensitivity in human ovarian cancer cells via targeting E2F3.

Mol Med Rep 2019 Apr 4. Epub 2019 Apr 4.

Department of Gynecology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.

The potential role of microRNA (miR)‑210‑3p in carcinogenesis and the cisplatin sensitivity of ovarian cancer were evaluated in the present study. The relative expression levels of miR‑210‑3p in cisplatin‑sensitive SKOV‑3 cells and cisplatin‑resistant SKOV‑3/DDP cells were determined using reverse transcription‑quantitative polymerase chain reaction analysis. miR‑210‑3p mimics and inhibitors were transfected into SKOV‑3/DDP cells. Read More

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http://dx.doi.org/10.3892/mmr.2019.10129DOI Listing

Hypercholesterolaemia increases the risk of high‑turnover osteoporosis in men.

Mol Med Rep 2019 Apr 4. Epub 2019 Apr 4.

Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.

As the incidence of osteoporosis (OP) and hypercholesterolaemia in men has increased, male OP has drawn more attention from clinicians worldwide. The present study sought to investigate the effects of cholesterol on male bone. Between July 2015 and October 2015, 216 men (aged ≥18 years) were recruited for this cross‑sectional study. Read More

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http://dx.doi.org/10.3892/mmr.2019.10131DOI Listing

Identification of potential diagnostic biomarkers for pneumonia caused by adenovirus infection in children by screening serum exosomal microRNAs.

Mol Med Rep 2019 May 29;19(5):4306-4314. Epub 2019 Mar 29.

Department of Respiratory Medicine, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.

Human adenovirus (HAdV) infection causes serious pneumonia in children, leading to significant morbidity and mortality rates. However, diagnostic biomarkers for HAdV‑associated pneumonia are unavailable. Serum microRNAs (miRNAs/miRs) have been recently reported as diagnostic biomarkers for several diseases. Read More

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http://dx.doi.org/10.3892/mmr.2019.10107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471624PMC
May 2019
2 Reads
1.484 Impact Factor

Prenatal nicotine exposure induces depression‑like behavior in adolescent female rats via modulating neurosteroid in the hippocampus.

Mol Med Rep 2019 May 29;19(5):4185-4194. Epub 2019 Mar 29.

Department of Pharmacology, Medical School of Yangtze University, Jingzhou, Hubei 434023, P.R. China.

Prenatal nicotine exposure (PNE) is closely related to depression in offspring. However, the underlying mechanism is still unclear. We hypothesized that neurosteroid in the hippocampus may mediate PNE‑induced depression‑like behaviors. Read More

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http://dx.doi.org/10.3892/mmr.2019.10105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471439PMC

A novel NHS mutation in a Chinese family with Nance‑Horan Syndrome.

Mol Med Rep 2019 May 29;19(5):4419-4424. Epub 2019 Mar 29.

Graduate School of Peking Union Medical College, Beijing 100730, P.R. China.

Nance‑Horan syndrome (NHS) is a rare X‑linked disorder with various clinical manifestations. The present study aimed to identify the pathogenic mutation causing NHS in a three‑generation Chinese family with 4 individuals presenting primarily with congenital cataracts. The genomic DNA of 5 individuals was collected, and family history and clinical information were recorded. Read More

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http://dx.doi.org/10.3892/mmr.2019.10106DOI Listing

Identification of suitable reference genes for gene expression studies in rat skeletal muscle following sciatic nerve crush injury.

Mol Med Rep 2019 May 28;19(5):4377-4387. Epub 2019 Mar 28.

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co‑innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, P.R. China.

Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) is a molecular biological method used to assess gene expression characterized by high simplicity, effectiveness, specificity and sensitivity. The selection of a suitable reference gene for normalization is critical for the accuracy of quantitative results. Peripheral nerve injury is a common clinical disorder that affects multiple tissues and organs, including peripheral nerves, neurons and the innervated muscles. Read More

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http://dx.doi.org/10.3892/mmr.2019.10102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472138PMC
May 2019
1 Read

Pharmacological inhibition of EZH2 combined with DNA‑damaging agents interferes with the DNA damage response in MM cells.

Mol Med Rep 2019 May 21;19(5):4249-4255. Epub 2019 Mar 21.

Department of Hematology, People's Liberation Army Center of Hematologic Disorders, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi 710032, P.R. China.

Enhancer of zeste homolog 2 (EZH2) serves a pivotal role in epigenetic silencing by acting as a histone methyltransferase. It has been confirmed that EZH2 overexpression occurs in different types of cancer and is involved in drug resistance, while it remains unclear how a DNA‑damaging event may promote EZH2 expression in multiple myeloma (MM) cells and how EZH2 influences its susceptibility to death in response to DNA‑damaging chemotherapy. The present study examined the impact of EZH2 inhibition on DNA damage‑induced apoptosis in MM cells and elucidated its underlying molecular mechanism. Read More

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http://dx.doi.org/10.3892/mmr.2019.10075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471932PMC
May 2019
2 Reads

The anticancer effects of cinobufagin on hepatocellular carcinoma Huh‑7 cells are associated with activation of the p73 signaling pathway.

Mol Med Rep 2019 May 29;19(5):4119-4128. Epub 2019 Mar 29.

Department of Gastroenterology and Hepatology, The Third Central Hospital of Tianjin, Tianjin 300170, P.R. China.

The Na+/K+‑ATPase inhibitor cinobufagin exhibits numerous anticancer effects on hepatocellular carcinoma (HCC) cells expressing wild‑type p53 via inhibition of aurora kinase A (AURKA) and activation of p53 signaling. However, the effects of cinobufagin on HCC cells expressing mutant p53 remain unclear. In the present study, the anticancer effects of cinobufagin were investigated on HCC Huh‑7 cells with mutant p53, and the effects of AURKA overexpression or inhibition on the anticancer effects of cinobufagin were analyzed. Read More

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http://dx.doi.org/10.3892/mmr.2019.10108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471725PMC
May 2019
2 Reads

MicroRNA‑302a upregulation mediates chemo‑resistance in prostate cancer cells.

Mol Med Rep 2019 May 28;19(5):4433-4440. Epub 2019 Mar 28.

Department of Urology, Carson International Cancer Centre, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy Centre, Shenzhen University, Shenzhen, Guangdong 518000, P.R. China.

MicroRNAs (miRNAs) are post‑transcriptional regulators that mediate the initiation and progression of human cancer. Growing evidence suggests that deregulation of miRNA expression levels underlies chemo‑resistance. To investigate whether miRNA‑302a (miR‑302a) is involved in mediating chemo‑resistance to paclitaxel in prostate cancer, a series of in vitro analyses were performed in paclitaxel‑resistant prostate cancer PC‑3PR cells and non‑resistant prostate cancer PC‑3 cells. Read More

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http://dx.doi.org/10.3892/mmr.2019.10098DOI Listing
May 2019
4 Reads

Bioinformatics analysis of the prognostic value of CCT6A and associated signalling pathways in breast cancer.

Mol Med Rep 2019 May 28;19(5):4344-4352. Epub 2019 Mar 28.

Department of Head and Neck Surgery, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian 350001, P.R. China.

Breast cancer (BC) is the most frequently diagnosed type of cancer and the leading cause of cancer‑associated mortality among women worldwide. However, the molecular basis for the pathogenesis of BC requires further exploration. Recent studies have demonstrated that chaperonin‑containing TCP1 subunit 6A (CCT6A) efficiently suppresses transforming growth factor‑β‑mediated metastasis by inhibiting the function of SMAD family member 2 in lung cancer. Read More

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http://dx.doi.org/10.3892/mmr.2019.10100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472137PMC
May 2019
2 Reads

Upregulation of microRNA‑16 alters the response to inhaled β‑agonists in patients with asthma though modulating expression of ADRB2.

Mol Med Rep 2019 May 28;19(5):4027-4034. Epub 2019 Mar 28.

Department of Neurological Intensive Care Unit, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.

MicroRNAs (miRNAs) are non‑coding RNAs of ~22 nucleotides in length, which serve an important role in numerous diseases. Asthma is a chronic airway inflammatory disease, which is the most common chronic disease among children. The role of miRNA (miR)‑16 in asthma is unclear. Read More

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http://dx.doi.org/10.3892/mmr.2019.10097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471313PMC

miR‑329‑3p regulates neural stem cell proliferation by targeting E2F1.

Mol Med Rep 2019 May 28;19(5):4137-4146. Epub 2019 Mar 28.

Department of Orthopaedic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

Neural stem cells (NSCs) are a class of self‑renewing and undifferentiated progenitor cells that retain the ability to differentiate to neurons, astrocytes and oligodendrocytes. MicroRNAs (miRNAs) are small noncoding RNAs that serve crucial roles in regulating a number of cellular processes, including cell proliferation, differentiation and apoptosis. Our previous GeneChip data indicated that the expression of miR‑329‑3p was increased in neurons compared with NSCs. Read More

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http://dx.doi.org/10.3892/mmr.2019.10096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472110PMC

MicroRNA‑195‑5p inhibitor prevents the development of osteoarthritis by targeting REGγ.

Mol Med Rep 2019 04 3. Epub 2019 Apr 3.

Department of Neonatology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Osteoarthritis (OA) is a common inflammatory joint disease. MicroRNAs (miRNAs/miRs) have been reported to be involved in the pathogenesis of OA; however, the role of miRNAs in OA remains largely unexplained. The purpose of the present study was to investigate the expression and role of miR‑195‑5p in OA, and to further explore the mechanism. Read More

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http://dx.doi.org/10.3892/mmr.2019.10124DOI Listing
April 2019
5 Reads

Production of an aberrant splice variant of CCL5 is not caused by genetic mutation in the mammary glands of mastitis‑infected Holstein cows.

Mol Med Rep 2019 May 28;19(5):4159-4166. Epub 2019 Mar 28.

Dairy Cattle Research Center, Shandong Academy of Agricultural Sciences, Jinan, Shandong 250100, P.R. China.

Genetic mutations, including single nucleotide polymorphisms (SNPs), result in aberrant alternatively splicing of gene and involves in susceptibility of inflammatory diseases, including bovine mastitis. C‑C motif chemokine ligand 5 (CCL5) is an immune‑associated gene, but its alternative splicing (AS) mechanism of gene expression has not yet been understood. The present study identified the splice variant of CCL5 and the compared differential expression of various transcripts between healthy and mastitic mammary gland tissue from cows. Read More

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http://dx.doi.org/10.3892/mmr.2019.10103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472127PMC
May 2019
1 Read

Comparative analysis of gene expression profiles in children with type 1 diabetes mellitus.

Mol Med Rep 2019 May 28;19(5):3989-4000. Epub 2019 Mar 28.

Department of Pediatrics, Shandong Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China.

Type 1 diabetes (T1D) is an autoimmune disease that is typically diagnosed in children. The aim of the present study was to identify potential genes involved in the pathogenesis of childhood T1D. Two datasets of mRNA expression in children with T1D were obtained from the Gene Expression Omnibus (GEO). Read More

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http://dx.doi.org/10.3892/mmr.2019.10099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472094PMC
May 2019
2 Reads

Long noncoding RNA NEAT1 sponges miR‑125a‑5p to suppress cardiomyocyte apoptosis via BCL2L12.

Mol Med Rep 2019 May 27;19(5):4468-4474. Epub 2019 Mar 27.

Department of Cardiology, Guangdong Cardiovascular Research Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510515, P.R. China.

Increasing evidence has suggested that long non‑coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) has critical roles in multiple biological processes; however, few studies have reported on its function in heart disease. The present study indicated that NEAT1 expression is markedly downregulated in cardiomyocytes following ischemia/reperfusion injury in vivo and hydrogen peroxide treatment in vitro. Further experiments suggested that ectopic overexpression of NEAT1 suppresses cardiomyocyte apoptosis induced by hydrogen peroxide, as assessed by TUNEL assay and flow cytometry. Read More

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http://dx.doi.org/10.3892/mmr.2019.10095DOI Listing
May 2019
2 Reads

miR‑146a‑5p expression is upregulated by the CXCR4 antagonist TN14003 and attenuates SDF‑1‑induced cartilage degradation.

Mol Med Rep 2019 May 21;19(5):4388-4400. Epub 2019 Mar 21.

Department of Sports Medicine, The First Affiliated Hospital, Kunming Medical University, Kunming, Yunnan 650000, P.R. China.

Osteoarthritis (OA) is an aseptic inflammatory disease which is associated with the stromal cell‑derived factor 1/C‑X‑C chemokine receptor type 4 (SDF‑1/CXCR4) axis. Accumulating studies have identified numbers of microRNAs (miRNAs) that serve important roles in the pathogenesis of OA. However, whether and how the inhibition of the SDF‑1/CXCR4 axis induces alterations in miRNA expression remains largely unclear. Read More

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http://dx.doi.org/10.3892/mmr.2019.10076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472139PMC
May 2019
5 Reads
1.484 Impact Factor

Ginsenoside Rg5 induces apoptosis in human esophageal cancer cells through the phosphoinositide‑3 kinase/protein kinase B signaling pathway.

Mol Med Rep 2019 May 27;19(5):4019-4026. Epub 2019 Mar 27.

Department of General Surgery, The China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130000, P.R. China.

The role of ginsenoside in the prevention of cancer has been well established. Ginsenoside Rg5 is one of the main components isolated from red ginseng, which has been demonstrated to have anti‑tumor effects by inhibiting cell proliferation and causing DNA damage. However, the role of ginsenoside Rg5 and its molecular mechanisms remain unclear in human esophageal cancer. Read More

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http://dx.doi.org/10.3892/mmr.2019.10093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471319PMC
May 2019
3 Reads
1.484 Impact Factor

FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition.

Mol Med Rep 2019 May 27;19(5):4101-4108. Epub 2019 Mar 27.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.

Although forkhead box protein M1 (FOXM1) is markedly upregulated in human premalignant and oral squamous cell carcinoma (OSCC) tissues and cultured cells, the association of FOXM1 expression with OSCC prognosis is not well understood. The present study investigated the possible association of FOXM1 expression in patients with OSCC with their clinicopathological characteristics and clinical outcomes. The expression of FOXM1 protein in OSCC tissues from 119 patients was evaluated by immunohistochemistry, and the results demonstrated that FOXM1 overexpression in patients with OSCC was associated with tumour recurrence and poor prognosis. Read More

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http://www.spandidos-publications.com/10.3892/mmr.2019.10094
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http://dx.doi.org/10.3892/mmr.2019.10094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471394PMC
May 2019
2 Reads

Revealing the interaction between intrauterine adhesion and vaginal microbiota using high‑throughput sequencing.

Mol Med Rep 2019 May 27;19(5):4167-4174. Epub 2019 Mar 27.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Intrauterine adhesion (IUA) is one of the most common diseases of the reproductive system. Due to the high postoperative recurrence rate of IUA, it is crucial to identify the possible causes of pathogenesis and recurrence of this disease. In the present study, a high‑throughput sequencing approach was applied to compare the vaginal microbiota between healthy women [healthy vaginal secretion (HVS) group] and patients with IUA [intrauterine adhesion patients' vaginal secretion (IAVS) group]. Read More

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http://dx.doi.org/10.3892/mmr.2019.10092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472106PMC
May 2019
1 Read

Shikonin inhibits proliferation and induces apoptosis in glioma cells via downregulation of CD147.

Mol Med Rep 2019 May 28;19(5):4335-4343. Epub 2019 Mar 28.

Institute of Basic and Translational Medicine, and Department of Immunology, Shaanxi Key Laboratory of Brain Disorders, Xi'an Medical University, Xi'an, Shaanxi 710021, P.R. China.

Shikonin, a traditional Chinese medicine, has been identified as being capable of inducing apoptosis in various tumors, including glioma, and is thus considered to be a promising therapeutic agent for tumor therapy. However, little is known about the molecular mechanism of shikonin in glioma. The present study investigated the influence of shikonin on the proliferation and apoptosis of glioma cells U251 and U87MG and explored the potential molecular mechanisms. Read More

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http://dx.doi.org/10.3892/mmr.2019.10101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472142PMC
May 2019
1 Read
1.484 Impact Factor

CBX3 predicts an unfavorable prognosis and promotes tumorigenesis in osteosarcoma.

Mol Med Rep 2019 May 28;19(5):4205-4212. Epub 2019 Mar 28.

Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453000, P.R. China.

CBX3, namely chromobox protein homolog 3, a member of the heterochomatin protein 1 (HP1) family, has been shown to be associated with the tumorigenesis of various types of cancer. The aim of the present study was to assess the biological role and the clinicopathological importance of CBX3 in osteosarcoma. The Oncomine database was utilized to determine the CBX3 expression in sarcoma patients. Read More

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http://dx.doi.org/10.3892/mmr.2019.10104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470990PMC
May 2019
4 Reads

Triptolide inhibits migration and proliferation of fibroblasts from ileocolonic anastomosis of patients with Crohn's disease via regulating the miR‑16‑1/HSP70 pathway.

Mol Med Rep 2019 Apr 3. Epub 2019 Apr 3.

Department of General Surgery, Southeast University Medical School, Nanjing, Jiangsu 210009, P.R. China.

Anastomotic fibrosis is highly likely to lead to reoperation in Crohn's disease (CD) patients. Triptolide (TPL) is considered to have anti‑inflammatory and antifibrotic effects in a variety of autoimmune diseases, including CD. The present study aimed to investigate the effects of TPL on fibroblasts from strictured ileocolonic anastomosis of patients with CD and its underlying mechanism. Read More

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http://dx.doi.org/10.3892/mmr.2019.10117DOI Listing
April 2019
2 Reads

Transgelin 2 overexpression inhibits cervical cancer cell invasion and migration.

Mol Med Rep 2019 Apr 3. Epub 2019 Apr 3.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China.

Cervical cancer is a malignancy that threatens female health. The present study aimed to investigate the role of transgelin 2 (TAGLN2) in cervical cancer. Reverse transcription‑quantitative polymerase chain reaction and western blotting were conducted to detect the mRNA and protein expression levels of particular factors in HeLa cells. Read More

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http://dx.doi.org/10.3892/mmr.2019.10116DOI Listing
April 2019
3 Reads

Protective effects of propofol on experimental neonatal acute lung injury.

Mol Med Rep 2019 May 1;19(5):4507-4513. Epub 2019 Apr 1.

Department of Pediatric Surgery, Maternal and Child Health Care Hospital of Qujing, Qujing, Yunnan 655000, P.R. China.

The present study aimed to investigate the effects of propofol on neonatal acute lung injury (ALI) in a rat model and to examine the molecular mechanisms underlying propofol function. A rat model of ALI was established by intraperitoneal injection of lipopolysaccharides (LPS). The neonatal rats were treated with various concentrations of propofol and a lung injury score was assessed. Read More

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http://dx.doi.org/10.3892/mmr.2019.10113DOI Listing
May 2019
6 Reads

Novel agent #2714 potently inhibits lung cancer growth by suppressing cell proliferation and by inducing apoptosis in vitro and in vivo.

Mol Med Rep 2019 Apr 2. Epub 2019 Apr 2.

School of Basic Medicine, Anhui Medical University, Hefei, Anhui 230032, P.R. China.

The use of small molecule compounds to inhibit cell proliferation is one of the most promising approaches in cancer therapy. In the present study, a cell viability assay, flow cytometry analysis, western blotting and mouse xenograft models were used to investigate the anticancer activities of #2714 and its underlying mechanisms in lung cancer. The present in vitro results suggested that #2714 significantly inhibited the viability of the human non‑small cell lung cancer line SPC‑A1 in a concentration‑ and time‑dependent manner, with a half‑maximal inhibitory concentration value of 5. Read More

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http://dx.doi.org/10.3892/mmr.2019.10114DOI Listing
April 2019
1 Read

Salidroside suppresses the metastasis of hepatocellular carcinoma cells by inhibiting the activation of the Notch1 signaling pathway.

Mol Med Rep 2019 Apr 2. Epub 2019 Apr 2.

Digestive Disease Key Laboratory of Qingdao, Qingdao, Shandong 266071, P.R. China.

Salidroside (SDS) is a phenylpropanoid glycoside isolated from Rhodiola rosea L. It exhibits multiple pharmacological properties in clinical medicine and has been commonly used in traditional Chinese medicine. The present study investigated the inhibitory effects of SDS on tumor invasion and migration, and the expression of metastasis‑related genes in highly metastatic hepatocellular carcinoma (HCC) cells (MHCC97H) in vitro. Read More

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http://dx.doi.org/10.3892/mmr.2019.10115DOI Listing
April 2019
3 Reads

Regulation of histone arginine methylation/demethylation by methylase and demethylase (Review).

Mol Med Rep 2019 May 1;19(5):3963-3971. Epub 2019 Apr 1.

Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210097, P.R. China.

Histone arginine methylation is a universal post‑translational modification that has been implicated in multiple cellular and sub‑cellular processes, including pre‑mRNA splicing, DNA damage signaling, mRNA translation, cell signaling and cell death. Despite these important roles, the understanding of its regulation with respect to certain other modifications, such as phosphorylation and acetylation, is very poor. Thus far, few histone arginine demethylases have been identified in mammalian cells, compared with nine protein arginine methyltransferases (PRMTs) that have been reported. Read More

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http://www.spandidos-publications.com/10.3892/mmr.2019.10111
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http://dx.doi.org/10.3892/mmr.2019.10111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471501PMC
May 2019
2 Reads

Inhibition of miR‑214 attenuates the migration and invasion of triple‑negative breast cancer cells.

Mol Med Rep 2019 May 1;19(5):4035-4042. Epub 2019 Apr 1.

Thyroid‑Breast Surgery Department, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, P.R. China.

Triple‑negative breast cancer (TNBC) is a subtype of breast cancer. MicroRNA (miR)‑214 is closely associated with controlling the development of tumor cells; therefore, in the present study, the target gene and effects of miR‑214 on TNBC cells were explored. Luciferase activity was examined by luciferase reporter assay. Read More

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http://dx.doi.org/10.3892/mmr.2019.10112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471216PMC
May 2019
2 Reads
1.484 Impact Factor

A novel compound heterozygous mutation in SLC5A2 contributes to familial renal glucosuria in a Chinese family, and a review of the relevant literature.

Mol Med Rep 2019 May 1;19(5):4364-4376. Epub 2019 Apr 1.

Department of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China.

Familial renal glucosuria (FRG) is a rare condition that involves isolated glucosuria despite normal blood glucose levels. Mutations in the solute carrier family 5 member 2 (SLC5A2) gene, which encodes sodium‑glucose cotransporter 2 (SGLT2), have been reported to be responsible for the disease. Genetic testing of the SLC5A2 gene was conducted in a Chinese family with FRG. Read More

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http://dx.doi.org/10.3892/mmr.2019.10110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472135PMC

TGF‑β1 upregulates the expression of lncRNA‑ATB to promote atherosclerosis.

Mol Med Rep 2019 May 29;19(5):4222-4228. Epub 2019 Mar 29.

Department of Cardiovascular Medicine, The Fourth People's Hospital of Jinan, Jinan Research Institute of Cardiovascular Diseases, Jinan, Shandong 250031, P.R. China.

Transforming growth factor (TGF)‑β1 is reported to be associated with the occurrence of atherosclerosis, although the mechanism remains unclear. Therefore, the present study aimed to investigate the involvement of TGF‑β1 signaling in atherosclerosis. A total of 56 patients with atherosclerosis and 44 healthy volunteers were involved in this study. Read More

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http://dx.doi.org/10.3892/mmr.2019.10109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471400PMC
May 2019
3 Reads

MicroRNA‑494 inhibits apoptosis of murine vascular smooth muscle cells in vitro.

Mol Med Rep 2019 May 26;19(5):4457-4467. Epub 2019 Mar 26.

Department of Urologic Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.

Apoptosis of vascular smooth muscle cells (VSMCs) is a process that regulates vessel remodeling in various cardiovascular diseases. The specific mechanisms that control VSMC apoptosis remain unclear. The present study aimed to investigate whether microRNA‑494 (miR‑494) is involved in regulating VSMC apoptosis and its underlying mechanisms. Read More

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http://dx.doi.org/10.3892/mmr.2019.10085DOI Listing
May 2019
1 Read

Effects of granulocyte colony‑stimulating factor on rabbit carotid and porcine heart models of chronic obliterative arterial disease.

Mol Med Rep 2019 Apr 3. Epub 2019 Apr 3.

Department of Cardiovascular Diseases, Tongji Hospital of Tongji University, Shanghai 200065, P.R. China.

Previous studies suggest that granulocyte colony‑stimulating factor (G‑CSF) can promote bone marrow derived progenitor cells to mediate cardiovascular repair, potentially reversing mechanical dysfunction in chronic ischaemic heart disease and post myocardial infarction. Two models were used in the present study both using a surgical ameroid constrictor to induce arterial stenosis. The first model used the carotid artery of rabbits. Read More

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http://dx.doi.org/10.3892/mmr.2019.10120DOI Listing
April 2019
6 Reads

Role of TLR‑4 in anti‑β2‑glycoprotein I‑induced activation of peritoneal macrophages and vascular endothelial cells in mice.

Mol Med Rep 2019 May 26;19(5):4353-4363. Epub 2019 Mar 26.

Department of Internal Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.

Anti‑phospholipid syndrome (APS) is a systematic autoimmune disease that is associated with presence of antiphospholipid antibodies (aPL), recurrent thrombosis, and fetal morbidity in pregnancy. Toll‑like receptor‑4 (TLR‑4), a member of TLR family, is known to have a fundamental role in pathogen recognition and activation of innate immunity. The β2‑glycoprotein I (β2GPI), a protein circulating in the blood at a high concentration, is able of scavenging lipopolysaccharide (LPS) and clear unwanted anionic cellular remnants, such as microparticles, from the circulation. Read More

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http://dx.doi.org/10.3892/mmr.2019.10084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472140PMC
May 2019
3 Reads

Mutational spectrum and associations with clinical features in patients with acute myeloid leukaemia based on next‑generation sequencing.

Mol Med Rep 2019 May 22;19(5):4147-4158. Epub 2019 Mar 22.

Department of Haematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.

The aim of the present study was to examine the associations between 112 acute myeloid leukaemia (AML)‑associated genes and the prognosis and clinical features of AML using bioinformatics analysis in 62 patients with AML. A total of 61 gene mutations were identified, and ≥1 mutations were detected in 96.77% of the patients. Read More

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http://dx.doi.org/10.3892/mmr.2019.10081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471684PMC
May 2019
2 Reads

HPT axis‑independent TSHβ splice variant regulates the synthesis of thyroid hormone in mice.

Mol Med Rep 2019 May 22;19(5):4514-4522. Epub 2019 Mar 22.

Department of Pathology, Affiliated Hospital of Logistics University of Chinese People's Armed Police Force, Tianjin 300162, P.R. China.

Thyroid stimulating hormone (TSH) consists of an α‑subunit and a unique β‑subunit. The first in‑frame TSHβ splice variant produced by the cells of immune system was identified in 2009. The TSHβ splice variant and native TSHβ exhibit different expression profiles, and research has been conducted to elucidate the role of the TSHβ splice variant in different diseases. Read More

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http://dx.doi.org/10.3892/mmr.2019.10082DOI Listing
May 2019
4 Reads

miR‑494‑3p regulates lipopolysaccharide‑induced inflammatory responses in RAW264.7 cells by targeting PTEN.

Mol Med Rep 2019 May 26;19(5):4288-4296. Epub 2019 Mar 26.

State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.

MicroRNAs (miRNAs/miRs) serve important roles in regulating inflammatory responses at the post‑transcriptional level. In the present study, the limma package was used to analyze the GSE43300 array dataset downloaded from the Gene Expression Omnibus database. It was identified that several miRNAs, including miR‑494‑3p, were upregulated in lipopolysaccharide (LPS)‑treated RAW264. Read More

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http://dx.doi.org/10.3892/mmr.2019.10083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471187PMC
May 2019
1 Read