3,274 results match your criteria Molecular carcinogenesis[Journal]


Synergistic efficacy of RLIP inhibition and 2'-hydroxyflavanone against DMBA-induced mammary carcinogenesis in SENCAR mice.

Mol Carcinog 2019 Apr 21. Epub 2019 Apr 21.

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.

Substantial evidence suggests that 7,12-dimethylbenzanthracene (DMBA)-induced mammary carcinogenesis in mice mimics human breast cancer (BC) in many respects. Therefore, it has been used extensively to evaluate preventive and therapeutic agents for human BC. Mammary carcinogenesis induced by DMBA administration in female SENsitive to CARcinogen (SENCAR) mice was characterized by histopathological analysis of the mammary glands and alterations to the phosphatidylinositol 3-kinase/protein kinase B/cyclin-dependent kinase 1 (PI3K/Akt/CDK1) pathway. Read More

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http://dx.doi.org/10.1002/mc.23026DOI Listing
April 2019
6 Reads

miR-197-5p inhibits sarcomagenesis and induces cellular senescence via repression of KIAA0101.

Mol Carcinog 2019 Apr 18. Epub 2019 Apr 18.

RNAi and Functional Genomics Lab, Department of Life Science, National Institute of Technology, Rourkela, Odisha, India.

The abnormal expressions of microRNAs (miRNAs) are known to be associated with various pathophysiological processes that lead to the development of a plethora of diseases including cancer. Among several miRNAs studied so far, miR-197 has been reported to play a vital role either as an oncogene or tumor suppressor in different cancers. However, its role in carcinogenesis of fibrosarcoma has not yet been elucidated. Read More

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http://dx.doi.org/10.1002/mc.23021DOI Listing

Genome-wide expression profiling-based copy number variations and colorectal cancer risk in Chinese.

Mol Carcinog 2019 Apr 18. Epub 2019 Apr 18.

Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Genetic factors play important roles in colorectal carcinogenesis. This study was aimed to evaluate the effects of gene expression-related copy number variations (CNVs) on the risk of colorectal cancer in Chinese. Expression Quantitative Trait Locus (eQTL) mapping was conducted to explore the most regulatable gene expressions by CNVs among the whole genome based on publicly available data. Read More

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http://dx.doi.org/10.1002/mc.23015DOI Listing
April 2019
2 Reads

Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk.

Mol Carcinog 2019 Apr 17. Epub 2019 Apr 17.

Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina.

The liver kinase B1-AMP-activated protein kinase (LKB1-AMPK) pathway has been identified as a new target for cancer therapy, because it controls the glucose and lipid metabolism in response to alterations in nutrients and intracellular energy levels. In the present study, we aimed to identify genetic variants of the LKB1-AMPK pathway genes and their associations with pancreatic cancer (PanC) risk using 15 418 participants of European ancestry from two previously published PanC genome-wide association studies. We found that six novel tagging single-nucleotide polymorphisms (SNPs) (i. Read More

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http://dx.doi.org/10.1002/mc.23018DOI Listing

Senescence as a main mechanism of Ritonavir and Ritonavir-NO action against melanoma.

Mol Carcinog 2019 Apr 17. Epub 2019 Apr 17.

Department of Immunology, Institute for Biological Research "Siniša Stanković", Belgrade University, Belgrade, Serbia.

The main focus of this study is exploring the effect and mechanism of two HIV-protease inhibitors: Ritonavir and Ritonavir-nitric oxide (Ritonavir-NO) on in vitro growth of melanoma cell lines. NO modification significantly improved the antitumor potential of Ritonavir, as the IC values of Ritonavir-NO were approximately two times lower than IC values of the parental compound. Our results showed for the first time, that both compounds induced senescence in primary and metastatic melanoma cell lines. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.23020
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http://dx.doi.org/10.1002/mc.23020DOI Listing
April 2019
5 Reads

Exosome-transmitted p120-catenin suppresses hepatocellular carcinoma progression via STAT3 pathways.

Mol Carcinog 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgery, Klinikum rechts der Isar, The Technical University of Munich, Munich, Germany.

Hepatocellular carcinoma (HCC) is a fatal disease with increasing morbidity and poor prognosis due to surgical recurrence and metastasis. Moreover, the molecular mechanism of HCC progression remains unclear. Although the role of p120-catenin (p120ctn) in liver cancer is well studied, the effects of secreted p120ctn transported by exosomes are less understood. Read More

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http://dx.doi.org/10.1002/mc.23022DOI Listing

Potentially functional genetic variants in the TNF/TNFR signaling pathway genes predict survival of patients with non-small cell lung cancer in the PLCO cancer screening trial.

Mol Carcinog 2019 Apr 15. Epub 2019 Apr 15.

Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina.

The tumor necrosis factor (TNF)/TNF receptor (TNFR) pathway is known to influence survival of patients with cancer. We hypothesize that single nucleotide polymorphisms (SNPs) in the TNF/TNFR pathway genes related to apoptosis are associated with survival of patients with non-small cell lung cancer (NSCLC). We used 1185 patients with NSCLC in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial and 984 patients with NSCLC in the Harvard Lung Cancer Susceptibility Study as the discovery and validation datasets, respectively. Read More

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http://dx.doi.org/10.1002/mc.23017DOI Listing
April 2019
1 Read

Glutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3) promotes epithelial-mesenchymal transition in breast cancer cells by regulating SPDEF/CDH1 signaling.

Mol Carcinog 2019 Apr 11. Epub 2019 Apr 11.

Department of Laboratory Medicine, General Hospital of Southern Theatre Command of PLA, Guangzhou, China.

Glutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3) is an important excitatory neurotransmitter receptor that plays a significant role in various neurodegenerative diseases. However, the biological functions of GRIK3 in malignancies are largely unknown because of limited related studies. Here, we primarily reported that the expression of GRIK3 was higher in breast cancer tissues than in adjacent noncancerous tissues. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.23014
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http://dx.doi.org/10.1002/mc.23014DOI Listing
April 2019
4 Reads

PARP14 promotes the proliferation and gemcitabine chemoresistance of pancreatic cancer cells through activation of NF-κB pathway.

Mol Carcinog 2019 Apr 10. Epub 2019 Apr 10.

Department of General Surgery, The Affiliated Changzhou No. 2 People's Hospitalof Nanjing Medical University, Changzhou, China.

Pancreatic cancer (PC) is the most fatal gastrointestinal malignancy in the world, with a 5-year relative survival of only 8%. Poly(ADP-ribose) polymerase (PARP)14, a member of the macro-PARP subfamily proteins, has been reported to participate in various biologic and pathologic processes in multiple cancers. The roles and underlying molecular mechanisms of PARP14 in PC carcinogenesis, however, remain to be elucidated. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.23011
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http://dx.doi.org/10.1002/mc.23011DOI Listing
April 2019
2 Reads

Effects of supplemental calcium and vitamin D on tight-junction proteins and mucin-12 expression in the normal rectal mucosa of colorectal adenoma patients.

Mol Carcinog 2019 Apr 2. Epub 2019 Apr 2.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.

The physical gut barrier, comprised of a thick mucus layer and the epithelium, plays an important role in defense against microbes and foreign antigens. Calcium and vitamin D may be involved in maintaining the integrity of the intestinal mucosal barrier, the dysfunction of which may lead to endotoxemia and inflammation, and contribute to colorectal carcinogenesis. We investigated supplemental calcium (1200 mg, daily) and/or vitamin D (1000 IU daily) effects on intestinal barrier function-related biomarkers in a subset of 105 participants from a large colorectal adenoma recurrence chemoprevention clinical trial. Read More

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http://dx.doi.org/10.1002/mc.23010DOI Listing
April 2019
3 Reads

Molecular evidence supporting the precursor nature of atypical adenomatous hyperplasia of the prostate.

Mol Carcinog 2019 Mar 28. Epub 2019 Mar 28.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

Atypical adenomatous hyperplasia (AAH) of the prostate is characterized by lobular proliferation of closely packed small acini. It is hypothesized that AAH is a precursor lesion for low-grade prostate cancer arising from the transition zone. Telomere dysfunction is common during malignant transformation of epithelia. Read More

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http://dx.doi.org/10.1002/mc.23009DOI Listing
March 2019
1 Read

Silibinin inhibits ultraviolet B radiation-induced mast cells recruitment and bone morphogenetic protein 2 expression in the skin at early stages in Ptch(+/-) mouse model of basal cell carcinoma.

Mol Carcinog 2019 Mar 25. Epub 2019 Mar 25.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.

Around 80% of nonmelanoma skin cancers (NMSCs) are basal cell carcinoma (BCC), still studies evaluating the efficacy of chemopreventive agents during early stage/s of BCC development are lacking. Accordingly, utilizing the well-established patched (Ptch)+/- mouse model of ultraviolet B (UVB) radiation-induced BCC formation, we excised skin samples from UVB exposed Ptch+/- and Ptch+/+ mice before tumor formation to study the promotion/progression of BCC and to determine the efficacy and target/s of silibinin, a well-known skin cancer chemopreventive agent. UVB exposure for 1 month increased the number of mast cells in Ptch+/- mice by ~48% (P < 0. Read More

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http://dx.doi.org/10.1002/mc.23008DOI Listing
March 2019
2 Reads

Epimagnolin targeting on an active pocket of mammalian target of rapamycin suppressed cell transformation and colony growth of lung cancer cells.

Mol Carcinog 2019 Mar 18. Epub 2019 Mar 18.

Pharmaceutical Biochemistry, Basic Research Laboratory & BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future Pharmacy, College of Pharmacy, The Catholic University of Korea, Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, Republic of Korea.

Mammalian target of rapamycin (mTOR) has a pivotal role in carcinogenesis and cancer cell proliferation in diverse human cancers. In this study, we observed that epimagnolin, a natural compound abundantly found in Shin-Yi, suppressed cell proliferation by inhibition of epidermal growth factor (EGF)-induced G1/S cell-cycle phase transition in JB6 Cl41 cells. Interestingly, epimagnolin suppressed EGF-induced Akt phosphorylation strongly at Ser473 and weakly at Thr308 without alteration of phosphorylation of MAPK/ERK kinases (MEKs), extracellular signal-regulated kinase (ERKs), and RSK1, resulting in abrogation of the phosphorylation of GSK3β at Ser9 and p70S6K at Thr389. Read More

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http://dx.doi.org/10.1002/mc.23005DOI Listing

miR-20a inhibits hypoxia-induced autophagy by targeting ATG5/FIP200 in colorectal cancer.

Mol Carcinog 2019 Mar 18. Epub 2019 Mar 18.

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Autophagy is a highly conserved lysosome-mediated protective cellular process in which cytosolic components, including damaged organelles and long-lived proteins, are cleared. Many studies have shown that autophagy was upregulated in hypoxic regions. However, the precise molecular mechanism of hypoxia-induced autophagy in colorectal cancer (CRC) is still elusive. Read More

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http://dx.doi.org/10.1002/mc.23006DOI Listing
March 2019
1 Read

The synthetic retinoid ST1926 attenuates prostate cancer growth and potentially targets prostate cancer stem-like cells.

Mol Carcinog 2019 Mar 18. Epub 2019 Mar 18.

Department of Anatomy, Cell Biology, and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

Retinoids are vitamin A derivatives that regulate crucial biological processes such as cellular proliferation, apoptosis, and differentiation. The use of natural retinoids in cancer therapy is limited due to their toxicity and the acquired resistance by cancer cells. Therefore, synthetic retinoids were developed, such as the atypical adamantyl retinoid ST1926 that provides enhanced bioavailability and reduced toxicity. Read More

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http://dx.doi.org/10.1002/mc.23004DOI Listing
March 2019
1 Read

Receptor tyrosine kinase recepteur d'origine nantais as predictive marker for aggressive prostate cancer in African Americans.

Mol Carcinog 2019 Mar 11. Epub 2019 Mar 11.

Departments of Urology, The University of Texas Health, San Antonio, Texas.

Published evidence shows a correlation between several molecular markers and prostate cancer (PCa) progression including in African Americans (AAs) who are disproportionately affected. Our early detection efforts led to the identification of elevated levels of antiapoptotic protein, c-FLIP and its upstream regulatory factors such as androgen receptor (AR), recepteur d'origine nantais (RON), a receptor tyrosine kinase in human prostate tumors. The primary objective of this study was to explore whether these markers play a role in racial disparities using immunohistochemistry in prostatectomy samples from a cohort of AA, Hispanic Whites (HWs), and non-Hispanic Whites (NHWs). Read More

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http://dx.doi.org/10.1002/mc.23002DOI Listing
March 2019
5 Reads

Tumor suppressor KIF1Bβ regulates mitochondrial apoptosis in collaboration with YME1L1.

Mol Carcinog 2019 Mar 11. Epub 2019 Mar 11.

Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan.

KIF1Bβ, a member of the kinesin superfamily of motor proteins, is a haploinsufficient tumor suppressor mapped to chromosome 1p36.2, which is frequently deleted in neural crest-derived tumors, including neuroblastoma and pheochromocytoma. While KIF1Bβ acts downstream of the nerve growth factor (NGF) pathway to induce apoptosis, further molecular functions of this gene product have largely been unexplored. Read More

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http://doi.wiley.com/10.1002/mc.22997
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http://dx.doi.org/10.1002/mc.22997DOI Listing
March 2019
6 Reads

Green tea-induced epigenetic reactivation of tissue inhibitor of matrix metalloproteinase-3 suppresses prostate cancer progression through histone-modifying enzymes.

Mol Carcinog 2019 Mar 10. Epub 2019 Mar 10.

Department of Urology, Case Western Reserve University, Cleveland, Ohio.

Green tea polyphenols (GTPs) and their major constituent, epigallocatechin-3-gallate (EGCG), have been reported to demonstrate many interesting biological activities, including anticancer properties. Recent studies on prostate cancer provide strong evidence that epigenetic mechanisms are major players in the regulation of matrix metalloproteinases (MMPs) and their binding partner tissue inhibitor of MMPs (TIMPs) involved in prostate cancer progression. Here we demonstrate that GTP/EGCG mediate epigenetic reactivation of TIMP-3 that plays a key role in suppressing invasiveness and cancer progression. Read More

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http://dx.doi.org/10.1002/mc.23003DOI Listing
March 2019
6 Reads

Doxorubicin induces prostate cancer drug resistance by upregulation of ABCG4 through GSH depletion and CREB activation: Relevance of statins in chemosensitization.

Mol Carcinog 2019 Mar 4. Epub 2019 Mar 4.

Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.

Multidrug resistance mediated by ATP-binding cassette (ABC) transporters remains a major impediment to cancer chemotherapy. In the present study, we documented that doxorubicin (Dox) or cisplatin-induced prostate cancer (PCa) chemoresistance is predominantly mediated by the induction of ABCG4 in androgen-independent PCa cells. Treatment of DU-145 or PC-3 cells with Dox significantly enhanced the expression of ABCG4 that resulted in the efflux of intracellular Dox. Read More

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http://dx.doi.org/10.1002/mc.22996DOI Listing
March 2019
1 Read
4.808 Impact Factor

RASSF10 suppresses lung cancer proliferation and invasion by decreasing the level of phosphorylated LRP6.

Mol Carcinog 2019 Mar 4. Epub 2019 Mar 4.

Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, People's Republic of China.

Ras-association domain family (RASSF) proteins exert distinct cellular functions. The expression of RASSF10 in non-small cell lung cancer and its underlying mechanism have not been reported. Herein, we explored the roles of RASSF10 in lung cancer cells and potential molecular mechanisms. Read More

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http://dx.doi.org/10.1002/mc.23000DOI Listing
March 2019
1 Read

Junctional adhesion molecule-A is down-regulated in anaplastic thyroid carcinomas and reduces cancer cell aggressiveness by modulating p53 and GSK3 α/β pathways.

Mol Carcinog 2019 Mar 4. Epub 2019 Mar 4.

IRCCS SDN, Napoli, Italy.

Junctional adhesion molecule A (JAM-A) is a transmembrane protein that contributes to different biological process, including the epithelial to mesenchymal transition (EMT). Through an EMT profiler array, we explored the molecular players associated with human thyroid cancer progression and identified JAM-A as one of the genes mostly deregulated. The quantitative real-time polymerase chain reaction and immunohistochemistry analyses showed that downregulation of JAM-A occurred in anaplastic thyroid carcinoma (ATC) compared with normal thyroid (NT) and papillary thyroid carcinoma (PTC) tissues and correlated with extrathyroid infiltration, tumor size, and ATC histotype. Read More

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http://dx.doi.org/10.1002/mc.23001DOI Listing
March 2019
4 Reads

Interplay between bile acids and the gut microbiota promotes intestinal carcinogenesis.

Mol Carcinog 2019 Mar 3. Epub 2019 Mar 3.

Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.

The gut microbiota and the bile acid pool play pivotal roles in maintaining intestinal homeostasis. Bile acids are produced in the liver from cholesterol and metabolized in the intestine by the gut microbiota. Gut dysbiosis has been reported to be associated with colorectal cancer. Read More

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http://dx.doi.org/10.1002/mc.22999DOI Listing
March 2019
14 Reads

Differential effect of grape seed extract and its active constituent procyanidin B2 3,3″-di-O-gallate against prostate cancer stem cells.

Mol Carcinog 2019 Mar 3. Epub 2019 Mar 3.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.

The present study aimed to determine whether grape seed extract (GSE) procyanidin mix, and its active constituent procyanidin B2 3,3″-di-O-gallate (B2G2) have the potential to target cancer stem cells (CSCs) in prostate cancer (PCa). The CSC populations were isolated and purified based on CD44 -α2β1 surface markers in PCa cell lines LNCaP, C4-2B, 22Rv1, PC3, and DU145, and then subjected to prostasphere formation assays in the absence or presence of GSE or B2G2. Results indicated that at lower doses (<15 μg) , the GSE procyanidin mix produced activity in unsorted prostate cancer antigen (PCA) cells, but not in sorted; however, multiple treatments with low dose GSE over a course of time inhibited sphere formation by sorted PCA CSCs. Read More

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http://dx.doi.org/10.1002/mc.22995DOI Listing
March 2019
1 Read
4.808 Impact Factor

GAEC1 drives colon cancer progression.

Mol Carcinog 2019 Mar 1. Epub 2019 Mar 1.

School of Medicine, Griffith University, Gold Coast, Queensland, Australia.

Gene amplified in esophageal cancer 1 (GAEC1) expression and copy number changes are frequently associated with the pathogenesis of colorectal carcinomas. The current study aimed to identify the pathway and its transcriptional factors with which GAEC1 interacts within colorectal cancer, to gain a better understanding of the mechanics by which this gene exercises its effect on colorectal cancer. Two colonic adenocarcinoma cell lines (SW48 and SW480) and a nonneoplastic colon epithelial cell line (FHC) were transfected with GAEC1 to assess the oncogenic potential of GAEC1 overexpression. Read More

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http://dx.doi.org/10.1002/mc.22998DOI Listing
March 2019
4 Reads

The regulation of Neuropilin 1 expression by miR-338-3p promotes non-small cell lung cancer via changes in EGFR signaling.

Mol Carcinog 2019 Feb 27. Epub 2019 Feb 27.

Department of Respiratory Medicine, the First Affiliated Hospital of Soochow University, Suzhou, China.

Neuropilin 1 (NRP1) is a transmembrane glycoprotein that acts as a co-receptor for multiple extracellular ligands and typically performs growth-promoting functions in cancer cells. Accumulating evidence indicates that NRP1 is upregulated, and may be an independent predictor of cancer relapse and poor survival, in many cancer types, including non-small cell lung cancer (NSCLC). Recent evidence suggests that NRP1 affects tumour cell viability via the epidermal growth factor receptor (EGFR) and Erb-B2 receptor tyrosine kinase 2 (ErbB2) signalling pathways in venous endothelial cells and in multiple cancer cells. Read More

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http://dx.doi.org/10.1002/mc.22990DOI Listing
February 2019
1 Read

Aurora B kinase as a novel molecular target for inhibition the growth of osteosarcoma.

Mol Carcinog 2019 Feb 20. Epub 2019 Feb 20.

The Hormel Institute, University of Minnesota, Austin, Minnesota.

Osteosarcoma is the primary human malignant tumor affecting bone. This cancer most frequently arises in children and adolescents, with a second peak in those over the age of 50. Currently, surgery followed by radiotherapy and chemotherapy are the main treatments, but long-term positive effects are very poor. Read More

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http://doi.wiley.com/10.1002/mc.22993
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http://dx.doi.org/10.1002/mc.22993DOI Listing
February 2019
5 Reads

Inhibition of the hexosamine biosynthesis pathway potentiates cisplatin cytotoxicity by decreasing BiP expression in non-small-cell lung cancer cells.

Mol Carcinog 2019 Feb 20. Epub 2019 Feb 20.

Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico.

Platinum anticancer agents are essential components in chemotherapeutic regimens for non-small-cell lung cancer (NSCLC) patients ineligible for targeted therapy. However, platinum-based regimens have reached a plateau of therapeutic efficacy; therefore, it is critical to implement novel approaches for improvement. The hexosamine biosynthesis pathway (HBP), which produces amino-sugar N-acetyl-glucosamine for protein glycosylation, is important for protein function and cell survival. Read More

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http://dx.doi.org/10.1002/mc.22992DOI Listing
February 2019
2 Reads

ETS1 is coexpressed with ZEB2 and mediates ZEB2-induced epithelial-mesenchymal transition in human tumors.

Mol Carcinog 2019 Feb 20. Epub 2019 Feb 20.

Department of Molecular Biology and Genetics, Laboratory of Molecular Oncology, Gebze Technical University, Gebze/Kocaeli, Turkey.

Epithelial-mesenchymal transition (EMT) is an embryonic program that is reactivated in cancer and regulates the invasion and metastasis of tumor cells. Zinc finger E-box binding homeobox 2 (ZEB2) induces EMT by upregulating matrix metalloproteinases (MMP), yet MMP genes lack ZEB2 binding motif in their promoters. Recently, expression of MMPs was associated to the activation of ETS1 transcription factor; however, a link between ZEB2 and ETS proto-oncogene 1, transcription factor (ETS1) remains to be elucidated. Read More

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http://dx.doi.org/10.1002/mc.22994DOI Listing
February 2019
3 Reads

Antitumor Effect of Periplocin in TRAIL-Resistant gastric cancer cells via upregulation of death receptor through activating ERK1/2-EGR1 pathway.

Mol Carcinog 2019 Feb 9. Epub 2019 Feb 9.

Research Centre, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor family, induces apoptosis in a variety of cancer cells. However, gastric cancer (GC) cells are insensitive to TRAIL usually. In the previous study, we showed that Periplocin could induce apoptosis in GC cells via the activation of ERK1/2-EGR1 pathway. Read More

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http://doi.wiley.com/10.1002/mc.22991
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http://dx.doi.org/10.1002/mc.22991DOI Listing
February 2019
10 Reads
4.808 Impact Factor

Sohlh2 inhibits breast cancer cell proliferation by suppressing Wnt/β-catenin signaling pathway.

Mol Carcinog 2019 Feb 5. Epub 2019 Feb 5.

Key Laboratory for Experimental Teratology of the Ministry of Education, Department of Human Anatomy and Histology and Embryology, School of Basic Medical Science, Shandong University, Jinan, PR China.

Sohlh2 belongs to the superfamily of basic helix-loop-helix (bhlh) transcription factors. Aberrant expression of bhlh transcription factors has been shown to be associated with multiple tumorigenesis. We previously identified that sohlh2 functioned as a tumor suppressor in ovarian cancer. Read More

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http://dx.doi.org/10.1002/mc.22989DOI Listing
February 2019

Neuroplastin-β mediates S100A8/A9-induced lung cancer disseminative progression.

Mol Carcinog 2019 Feb 5. Epub 2019 Feb 5.

Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama-shi, Okayama, Japan.

Compiling evidence indicates an unusual role of extracellular S100A8/A9 in cancer metastasis. S100A8/A9 secreted from either cancer cells or normal cells including epithelial and inflammatory cells stimulates cancer cells through S100A8/A9 sensor receptors in an autocrine or paracrine manner, leading to cancer cell metastatic progression. We previously reported a novel S100A8/A9 receptor, neuroplastin-β (NPTNβ), which plays a critical role in atopic dermatitis when it is highly activated in keratinocytes by an excess amount of extracellular S100A8/A9 in the inflammatory skin lesion. Read More

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http://dx.doi.org/10.1002/mc.22987DOI Listing
February 2019
3 Reads
4.808 Impact Factor

AKT-dependent sugar addiction by benzyl isothiocyanate in breast cancer cells.

Mol Carcinog 2019 Feb 5. Epub 2019 Feb 5.

Department of Pharmacology & Chemical Biology, Pittsburgh, Pennsylvania.

The overall promise of breast cancer chemoprevention is exemplified by clinical success of selective estrogen receptor modulators and aromatase inhibitors. Despite clinical efficacy, these interventions have limitations, including rare but serious side effects and lack of activity against estrogen receptor-negative breast cancers. We have shown previously that dietary administration of benzyl isothiocyanate (BITC), which occurs naturally as a thioglucoside conjugate in edible cruciferous vegetables, inhibits development of estrogen receptor-negative breast cancer in mouse mammary tumor virus-neu (MMTV-neu) transgenic mice. Read More

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http://dx.doi.org/10.1002/mc.22988DOI Listing
February 2019
2 Reads
4.808 Impact Factor

Corrigendum.

Authors:

Mol Carcinog 2019 Mar;58(3):458

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http://dx.doi.org/10.1002/mc.22959DOI Listing

The HDAC6-selective inhibitor is effective against non-Hodgkin lymphoma and synergizes with ibrutinib in follicular lymphoma.

Mol Carcinog 2019 Jan 29. Epub 2019 Jan 29.

College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea.

Follicular lymphoma (FL) is the most common indolent B-cell non-Hodgkin lymphoma (NHL) with genetic alterations of BCL-2, KMT2B, and KMT6. FL is refractory to conventional chemotherapy and is still incurable in most patients. Thus, new drugs and/or novel combination treatment strategies are needed to further improve FL patient outcome. Read More

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http://dx.doi.org/10.1002/mc.22983DOI Listing
January 2019
2 Reads

Alteration of the tumor suppressor SARDH in sporadic colorectal cancer: A functional and transcriptome profiling-based study.

Mol Carcinog 2019 Jan 29. Epub 2019 Jan 29.

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, China.

Sporadic colorectal cancer (sCRC) is one of the leading causes of cancer death worldwide. As a highly heterogeneous complex disease, the currently reported classical genetic markers for sCRC, including APC, KRAS, BRAF, and TP53 gene mutations and epigenetic alterations, can explain only some sCRC patients. Here, we first reported a deleterious c. Read More

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http://dx.doi.org/10.1002/mc.22984DOI Listing
January 2019
11 Reads
4.808 Impact Factor

Transglutaminase 2 takes center stage as a cancer cell survival factor and therapy target.

Authors:
Richard L Eckert

Mol Carcinog 2019 Jan 29. Epub 2019 Jan 29.

Department of Biochemistry and Molecular Biology, Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland.

Transglutaminase 2 (TG2) has emerged as a key cancer cell survival factor that drives epithelial to mesenchymal transition, angiogenesis, metastasis, inflammation, drug resistance, cancer stem cell survival and stemness, and invasion and migration. TG2 can exist in a GTP-bound signaling-active conformation or in a transamidase-active conformation. The GTP bound conformation of TG2 contributes to cell survival and the transamidase conformation can contribute to cell survival or death. Read More

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http://doi.wiley.com/10.1002/mc.22986
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http://dx.doi.org/10.1002/mc.22986DOI Listing
January 2019
8 Reads

EGFL6 promotes cell proliferation in colorectal cancer via regulation of the WNT/β-catenin pathway.

Mol Carcinog 2019 Jan 29. Epub 2019 Jan 29.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.

Epidermal growth factor-like protein 6 (EGFL6) serves as an exocrine protein promoting proliferation and migration during carcinogenesis in ovarian cancer. However, its function and mechanisms in colorectal cancer (CRC) have not been completely explored. To investigate the role of EGFL6 in CRC cell growth, in vitro CCK8, colony formation assays, flow cytometric analysis of the cell cycle and apoptosis, and an in vivo tumor xenograft model were utilized. Read More

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http://dx.doi.org/10.1002/mc.22985DOI Listing
January 2019
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Functional polymorphisms on chromosome 5p15.33 disturb telomere biology and confer the risk of non-small cell lung cancer in Chinese population.

Mol Carcinog 2019 Jan 25. Epub 2019 Jan 25.

Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The chromosome 5p15.33 has been reported as a susceptibility locus for lung cancer. However, causal variants in this region have not been fully uncovered. Read More

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http://dx.doi.org/10.1002/mc.22980DOI Listing
January 2019
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4.808 Impact Factor

Identification of epithelial-specific ETS-1 (ESE-1) as a tumor suppressor and molecular target of green tea compound, EGCG.

Mol Carcinog 2019 Jan 24. Epub 2019 Jan 24.

Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, Maryland.

Epithelial specific ETS-1 (ESE-1) belongs to the E26 transformation-specific transcription factor superfamily and is of great interest as a potential target for managing several types of cancer. Despite its clinical significance, the documented effects of ESE-1 on cancer development and progression are contradictory and its underlying biological mechanism of action remains elusive. The objectives of this study are to investigate whether ESE-1 is a tumor suppressor and to identify dietary anti-cancer compound to activate ESE-1 expression in human colon cancer model. Read More

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http://doi.wiley.com/10.1002/mc.22981
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http://dx.doi.org/10.1002/mc.22981DOI Listing
January 2019
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NEK5 promotes breast cancer cell proliferation through up-regulation of Cyclin A2.

Mol Carcinog 2019 Jan 24. Epub 2019 Jan 24.

The Department of Breast Surgery, The Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, PR China.

NEK5, a contraction of NIMA Related Kinase 5, has been shown to regulate the centrosome integrity of cells though; it has been little described in cancer. Herein, to explore the clinicopathological meaning of NEK5 expression in breast cancer, immunohistochemistry was performed to detect the expression of NEK5 on tissue blocks, totaling 203 cases. Quantitative real-time PCR (qRT-PCR) was used to evaluate NEK5 mRNA expression with 30 cases of fresh tissues. Read More

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http://doi.wiley.com/10.1002/mc.22982
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http://dx.doi.org/10.1002/mc.22982DOI Listing
January 2019
17 Reads
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MIF promotes perineural invasion through EMT in salivary adenoid cystic carcinoma.

Mol Carcinog 2019 Jan 22. Epub 2019 Jan 22.

State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Macrophage migration inhibitory factor (MIF) is a prominent orchestrator during the onset and progression of cancer. Recently, MIF was detected in salivary adenoid cystic carcinoma (SACC). However, its functional effect in perineural invasion (PNI) of SACC remained unknown. Read More

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http://dx.doi.org/10.1002/mc.22979DOI Listing
January 2019
2 Reads
4.808 Impact Factor

Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines.

Mol Carcinog 2019 Jan 18. Epub 2019 Jan 18.

Facultad de Medicina, Departamento de Bioquímica, Universidad Nacional Autónoma de México, Mexico City, México.

The knowledge about the role of calcium-regulated pathways in cancer cell growth and differentiation could be useful for the development of new therapeutic approaches to diminish its mortality. The ATP2A genes encode for SERCA pumps, which modulate cytosolic Ca concentration, regulating various cellular processes including cell growth. ATP2A3 gene transcriptional down-regulation has been reported in gastric and colon cancer, but there is still a lack of understanding about the epigenetic processes regulating its transcription. Read More

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http://dx.doi.org/10.1002/mc.22978DOI Listing
January 2019
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Antitumor effects of circ-EPHB4 in hepatocellular carcinoma via inhibition of HIF-1α.

Mol Carcinog 2019 Jan 15. Epub 2019 Jan 15.

Department of Biochemistry, Guangzhou University of Chinese Medicine, Guangzhou, China.

The protein EPHB4 plays a vital role in various tumor types. However, few studies into the function of circ-EPHB4 (hsa_circ_0001730) in tumors have been conducted. This study aimed to investigate the functions of circ-EPHB4 and the underlying mechanism of circ-EPHB4 in regulating hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.1002/mc.22976DOI Listing
January 2019
3 Reads
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Non-coding and coding genomic variants distinguish prostate cancer, castration-resistant prostate cancer, familial prostate cancer, and metastatic castration-resistant prostate cancer from each other.

Mol Carcinog 2019 Jan 15. Epub 2019 Jan 15.

Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, South Australia, Australia.

A considerable number of deposited variants has provided new possibilities for knowledge discovery in different types of prostate cancer. Here, we analyzed variants located on 3'UTR, 5'UTR, CDs, Intergenic, and Intronic regions in castration-resistant prostate cancer (8496 variants), familial prostate cancer (3241 variants), metastatic castration-resistant prostate cancer (3693 variants), and prostate cancer (16599 variants). Chromosome regions 10p15-p14 and 2p13 were highly enriched (P < 0. Read More

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http://doi.wiley.com/10.1002/mc.22975
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http://dx.doi.org/10.1002/mc.22975DOI Listing
January 2019
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Cancer stem cells and fibroblast niche cross talk in an in-vitro oral dysplasia model.

Mol Carcinog 2019 Jan 15. Epub 2019 Jan 15.

Integrated Head and Neck Oncology Research Program, Mazumdar Shaw Centre for Translational Research, MSMF, Bangalore, India.

Understanding the cellular interactions during oral carcinogenesis has the potential to identify novel prognostic and therapeutic targets. This study aimed at investigating the cancer stem cell (CSC)-fibroblast niche interactions using in-vitro dysplastic cell line models developed from different stages of 4NQO-induced oral carcinogenic mice model. The spontaneously transformed epithelial cells (DysMSCTR6, 14 and 16) were developed from three time points (mild/moderate/severe), while two fibroblast cell lines (FibroMSCTR12, 16) were developed from moderate and severe dysplastic tissue. Read More

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http://doi.wiley.com/10.1002/mc.22974
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http://dx.doi.org/10.1002/mc.22974DOI Listing
January 2019
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Emerging role of EPHX1 in chemoresistance of acute myeloid leukemia by regurlating drug-metabolizing enzymes and apoptotic signaling.

Mol Carcinog 2019 Jan 15. Epub 2019 Jan 15.

Institute of Hematology, Changhai Hospital, Naval Medical University, Shanghai, China.

Microsomal epoxide hyrolase 1 (EPHX1) is a critical biotransformation enzyme and participants in both the detoxification and activation of potentially genotoxic epoxides. In this study, we firstly aimed to investigate the role of EPHX1 in the chemoresistance of acute myeloid leukemic cells to aclarubicin (ACM) and mitoxantrone (MIT). EPHX1 mRNA expression and prognosis were measured in acute myeloid leukemia (AML) patients, and the function of EPHX1 in leukemic cell viability and apoptosis induced by ACM and MIT was also measured. Read More

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http://doi.wiley.com/10.1002/mc.22973
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http://dx.doi.org/10.1002/mc.22973DOI Listing
January 2019
21 Reads

No difference in 4-nitroquinoline induced tumorigenesis between germ-free and colonized mice.

Mol Carcinog 2019 Jan 10. Epub 2019 Jan 10.

Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California.

Variations in oral bacterial communities have been linked to oral cancer suggesting that the oral microbiome is an etiological factor that can influence oral cancer development. The 4-nitroquinoline 1-oxide (4-NQO)-induced murine oral and esophageal cancer model is frequently used to assess the effects of preventive and/or therapeutic agents. We used this model to assess the impact of the microbiome on tumorigenesis using axenic (germ-free) and conventionally housed mice. Read More

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http://dx.doi.org/10.1002/mc.22972DOI Listing
January 2019
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Core fucosylation of copper transporter 1 plays a crucial role in cisplatin-resistance of epithelial ovarian cancer by regulating drug uptake.

Mol Carcinog 2019 Jan 5. Epub 2019 Jan 5.

College of Basic Medical Sciences, Dalian Medical University, Liaoning, China.

Core fucosylation catalyzed by core fucosyltransferase (Fut8) contributes to the progressions of epithelial ovarian cancer (EOC). Copper transporter 1 (CTR1), which contains one N-glycan on Asn , mediates cellular transport of cisplatin (cDDP), and plays an important role in the process of cDDP-resistance in EOC. In the present study, we found that the core fucosylation level elevated significantly in the sera of cDDP-treated EOC patients. Read More

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http://doi.wiley.com/10.1002/mc.22971
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http://dx.doi.org/10.1002/mc.22971DOI Listing
January 2019
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A functional variant rs1537373 in 9p21.3 region is associated with pancreatic cancer risk.

Mol Carcinog 2019 Jan 3. Epub 2019 Jan 3.

Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

9p21.3 has been identified as an unexpected hot point in multiple diseases GWAS including cancers, and we performed a two-stage case-control studies integrating functional assay strategy to find the potential functional variants modified susceptibility to pancreatic cancer (PC). An expanded Illumina HumanExome Beadchip of PC including 943 cases and 3908 controls was used to examine 39 tagSNPs in 9p21. Read More

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http://doi.wiley.com/10.1002/mc.22968
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http://dx.doi.org/10.1002/mc.22968DOI Listing
January 2019
11 Reads
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TIMM50 promotes tumor progression via ERK signaling and predicts poor prognosis of non-small cell lung cancer patients.

Mol Carcinog 2019 Jan 3. Epub 2019 Jan 3.

Department of Pathology, College of Basic Medical Science and the First Affiliated Hospital of China Medical University, Shenyang, China.

TIMM50 (Translocase of the inner mitochondrial membrane 50), also called TIM50, plays an essential role in mitochondrial membrane transportation. The existing literature suggests that TIMM50 may perform as an oncogenetic protein in breast cancer. However, the molecular mechanism, especially in human non-small cell lung cancer (NSCLC), is uncertain to date. Read More

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http://dx.doi.org/10.1002/mc.22969DOI Listing
January 2019
4 Reads