3,246 results match your criteria Molecular carcinogenesis[Journal]


Antitumor Effect of Periplocin in TRAIL-Resistant gastric cancer cells via upregulation of death receptor through activating ERK1/2-EGR1 pathway.

Mol Carcinog 2019 Feb 9. Epub 2019 Feb 9.

Research Centre, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor family, induces apoptosis in a variety of cancer cells. However, gastric cancer (GC) cells are insensitive to TRAIL usually. In the previous study, we showed that Periplocin could induce apoptosis in GC cells via the activation of ERK1/2-EGR1 pathway. Read More

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http://doi.wiley.com/10.1002/mc.22991
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http://dx.doi.org/10.1002/mc.22991DOI Listing
February 2019
4 Reads
4.808 Impact Factor

Sohlh2 inhibits breast cancer cell proliferation by suppressing Wnt/β-catenin signaling pathway.

Mol Carcinog 2019 Feb 5. Epub 2019 Feb 5.

Key Laboratory for Experimental Teratology of the Ministry of Education, Department of Human Anatomy and Histology&Embryology, School of Basic Medical Science, Shandong University, Jinan 250012, P.R. China.

Sohlh2 belongs to the superfamily of basic helix-loop-helix (bhlh) transcription factors. Aberrant expression of bhlh transcription factors has been shown to be associated with multiple tumorigenesis. We previously identified that sohlh2 functioned as a tumor suppressor in ovarian cancer. Read More

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http://dx.doi.org/10.1002/mc.22989DOI Listing
February 2019

NEUROPLASTIN-β MEDIATES S100A8/A9-INDUCED LUNG CANCER DISSEMINATIVE PROGRESSION.

Mol Carcinog 2019 Feb 5. Epub 2019 Feb 5.

Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama-shi, Okayama 700-8558, Japan.

Compiling evidence indicates an unusual role of extracellular S100A8/A9 in cancer metastasis. S100A8/A9 secreted from either cancer cells or normal cells including epithelial and inflammatory cells stimulates cancer cells through S100A8/A9 sensor receptors in an autocrine or paracrine manner, leading to cancer cell metastatic progression. We previously reported a novel S100A8/A9 receptor, neuroplastin-β (NPTNβ), which plays a critical role in atopic dermatitis when it is highly activated in keratinocytes by an excess amount of extracellular S100A8/A9 in the inflammatory skin lesion. Read More

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http://dx.doi.org/10.1002/mc.22987DOI Listing
February 2019
1 Read
4.808 Impact Factor

AKT-dependent sugar addiction by benzyl isothiocyanate in breast cancer cells.

Mol Carcinog 2019 Feb 5. Epub 2019 Feb 5.

Department of Pharmacology & Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

The overall promise of breast cancer chemoprevention is exemplified by clinical success of selective estrogen receptor modulators and aromatase inhibitors. Despite clinical efficacy, these interventions have limitations, including rare but serious side effects and lack of activity against estrogen receptor-negative breast cancers. We have shown previously that dietary administration of benzyl isothiocyanate (BITC), which occurs naturally as a thioglucoside conjugate in edible cruciferous vegetables, inhibits development of estrogen receptor-negative breast cancer in mouse mammary tumor virus-neu (MMTV-neu) transgenic mice. Read More

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http://dx.doi.org/10.1002/mc.22988DOI Listing
February 2019
1 Read
4.808 Impact Factor

Corrigendum.

Authors:

Mol Carcinog 2019 Mar;58(3):458

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http://dx.doi.org/10.1002/mc.22959DOI Listing

The HDAC6-selective inhibitor is effective against non-Hodgkin lymphoma and synergizes with ibrutinib in follicular lymphoma.

Mol Carcinog 2019 Jan 29. Epub 2019 Jan 29.

College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, 21983, Republic of Korea.

Follicular lymphoma (FL) is the most common indolent B-cell non-Hodgkin lymphoma (NHL) with genetic alterations of BCL-2, KMT2B, and KMT6. FL is refractory to conventional chemotherapy and is still incurable in most patients. Thus, new drugs and/or novel combination treatment strategies are needed to further improve FL patient outcome. Read More

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http://dx.doi.org/10.1002/mc.22983DOI Listing
January 2019
1 Read

Alteration of the tumour suppressor SARDH in sporadic colorectal cancer: a functional and transcriptome profiling-based study.

Mol Carcinog 2019 Jan 29. Epub 2019 Jan 29.

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, 710069, China.

Sporadic colorectal cancer (sCRC) is one of the leading causes of cancer death worldwide. As a highly heterogeneous complex disease, the currently reported classical genetic markers for sCRC, including APC, KRAS, BRAF and TP53 gene mutations and epigenetic alterations, can explain only some sCRC patients. Here, we first reported a deleterious c. Read More

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http://dx.doi.org/10.1002/mc.22984DOI Listing
January 2019
1 Read
4.808 Impact Factor

Transglutaminase 2 takes center stage as a cancer cell survival factor and therapy target.

Authors:
Richard L Eckert

Mol Carcinog 2019 Jan 29. Epub 2019 Jan 29.

Department of Biochemistry and Molecular Biology, and the Greenebaum Comprehensive Cancer Center at the University of Maryland School of Medicine, Baltimore, Maryland, 21201.

Transglutaminase 2 (TG2) has emerged as a key cancer cell survival factor that drives epithelial to mesenchymal transition, angiogenesis, metastasis, inflammation, drug resistance, cancer stem cell survival and stemness, and invasion and migration. TG2 can exist in a GTP-bound signaling-active conformation or in a transamidase-active conformation. The GTP bound conformation of TG2 contributes to cell survival and the transamidase conformation can contribute to cell survival or death. Read More

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http://doi.wiley.com/10.1002/mc.22986
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http://dx.doi.org/10.1002/mc.22986DOI Listing
January 2019
4 Reads

EGFL6 Promotes Cell Proliferation in Colorectal Cancer via Regulation of the WNT/β-catenin Pathway.

Mol Carcinog 2019 Jan 29. Epub 2019 Jan 29.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai 200001, China.

Epidermal growth factor-like protein 6 (EGFL6) serves as an exocrine protein promoting proliferation and migration during carcinogenesis in ovarian cancer. However, its function and mechanisms in colorectal cancer (CRC) have not been completely explored. To investigate the role of EGFL6 in CRC cell growth, in vitro CCK8, colony formation assays, flow cytometric analysis of the cell cycle and apoptosis, and an in vivo tumor xenograft model were utilized. Read More

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http://dx.doi.org/10.1002/mc.22985DOI Listing
January 2019
1 Read

Functional polymorphisms on chromosome 5p15.33 disturb telomere biology and confer the risk of non-small cell lung cancer in Chinese population.

Mol Carcinog 2019 Jan 25. Epub 2019 Jan 25.

Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The chromosome 5p15.33 has been reported as a susceptibility locus for lung cancer. However, causal variants in this region have not been fully uncovered. Read More

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http://dx.doi.org/10.1002/mc.22980DOI Listing
January 2019
1 Read
4.808 Impact Factor

Identification of epithelial-specific ETS-1 (ESE-1) as a tumor suppressor and molecular target of green tea compound, EGCG.

Mol Carcinog 2019 Jan 24. Epub 2019 Jan 24.

Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD 20742, USA.

Epithelial specific ETS-1 (ESE-1) belongs to the E26 transformation-specific transcription factor superfamily and is of great interest as a potential target for managing several types of cancer. Despite its clinical significance, the documented effects of ESE-1 on cancer development and progression are contradictory and its underlying biological mechanism of action remains elusive. The objectives of this study are to investigate whether ESE-1 is a tumor suppressor and to identify dietary anti-cancer compound to activate ESE-1 expression in human colon cancer model. Read More

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http://doi.wiley.com/10.1002/mc.22981
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http://dx.doi.org/10.1002/mc.22981DOI Listing
January 2019
6 Reads

NEK5 promotes breast cancer cell proliferation through up-regulation of Cyclin A2.

Mol Carcinog 2019 Jan 24. Epub 2019 Jan 24.

The Department of Breast Surgery, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, Anhui province, PR China.

NEK5, a contraction of NIMA Related Kinase 5, has been shown to regulate the centrosome integrity of cells though; it has been little described in cancer. Herein, to explore the clinicopathological meaning of NEK5 expression in breast cancer, immunohistochemistry was performed to detect the expression of NEK5 on tissue blocks, totaling 203 cases. Quantitative real-time PCR (qRT-PCR) was used to evaluate NEK5 mRNA expression with 30 cases of fresh tissues. Read More

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http://doi.wiley.com/10.1002/mc.22982
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http://dx.doi.org/10.1002/mc.22982DOI Listing
January 2019
7 Reads

MIF promotes perineural invasion through EMT in salivary adenoid cystic carcinoma.

Mol Carcinog 2019 Jan 22. Epub 2019 Jan 22.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No.14, Sec. 3, Renminnan Road, Chengdu Sichuan 610041, China.

Macrophage migration inhibitory factor (MIF) is a prominent orchestrator during the onset and progression of cancer. Recently, MIF was detected in salivary adenoid cystic carcinoma (SACC). However, its functional effect in perineural invasion (PNI) of SACC remained unknown. Read More

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http://dx.doi.org/10.1002/mc.22979DOI Listing
January 2019
1 Read
4.808 Impact Factor

Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines.

Mol Carcinog 2019 Jan 18. Epub 2019 Jan 18.

Facultad de Medicina, Departamento de Bioquímica, Universidad Nacional Autónoma de México, Mexico City, México.

The knowledge about the role of calcium-regulated pathways in cancer cell growth and differentiation could be useful for the development of new therapeutic approaches to diminish its mortality. The ATP2A genes encode for SERCA pumps, which modulate cytosolic Ca concentration, regulating various cellular processes including cell growth. ATP2A3 gene transcriptional down-regulation has been reported in gastric and colon cancer, but there is still a lack of understanding about the epigenetic processes regulating its transcription. Read More

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http://dx.doi.org/10.1002/mc.22978DOI Listing
January 2019
1 Read

Antitumor effects of circ-EPHB4 in hepatocellular carcinoma via inhibition of HIF-1α.

Mol Carcinog 2019 Jan 15. Epub 2019 Jan 15.

Department of Biochemistry, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

The protein EPHB4 plays a vital role in various tumor types. However, few studies into the function of circ-EPHB4 (hsa_circ_0001730) in tumors have been conducted. This study aimed to investigate the functions of circ-EPHB4 and the underlying mechanism of circ-EPHB4 in regulating hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.1002/mc.22976DOI Listing
January 2019
2 Reads
4.808 Impact Factor

Non-coding and coding genomic variants distinguish prostate cancer, castration-resistant prostate cancer, familial prostate cancer, and metastatic castration-resistant prostate cancer from each other.

Mol Carcinog 2019 Jan 15. Epub 2019 Jan 15.

Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, South Australia, Australia.

A considerable number of deposited variants has provided new possibilities for knowledge discovery in different types of prostate cancer. Here, we analyzed variants located on 3'UTR, 5'UTR, CDs, Intergenic, and Intronic regions in castration-resistant prostate cancer (8496 variants), familial prostate cancer (3241 variants), metastatic castration-resistant prostate cancer (3693 variants), and prostate cancer (16599 variants). Chromosome regions 10p15-p14 and 2p13 were highly enriched (P < 0. Read More

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http://doi.wiley.com/10.1002/mc.22975
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http://dx.doi.org/10.1002/mc.22975DOI Listing
January 2019
9 Reads

Cancer stem cells and fibroblast niche cross talk in an in-vitro oral dysplasia model.

Mol Carcinog 2019 Jan 15. Epub 2019 Jan 15.

Integrated Head and Neck Oncology Research Program, Mazumdar Shaw Centre for Translational Research, MSMF, Bangalore, India.

Understanding the cellular interactions during oral carcinogenesis has the potential to identify novel prognostic and therapeutic targets. This study aimed at investigating the cancer stem cell (CSC)-fibroblast niche interactions using in-vitro dysplastic cell line models developed from different stages of 4NQO-induced oral carcinogenic mice model. The spontaneously transformed epithelial cells (DysMSCTR6, 14 and 16) were developed from three time points (mild/moderate/severe), while two fibroblast cell lines (FibroMSCTR12, 16) were developed from moderate and severe dysplastic tissue. Read More

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http://doi.wiley.com/10.1002/mc.22974
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http://dx.doi.org/10.1002/mc.22974DOI Listing
January 2019
3 Reads

Emerging role of EPHX1 in chemoresistance of acute myeloid leukemia by regurlating drug-metabolizing enzymes and apoptotic signaling.

Mol Carcinog 2019 Jan 15. Epub 2019 Jan 15.

Institute of Hematology, Changhai Hospital, Naval Medical University, Shanghai, China.

Microsomal epoxide hyrolase 1 (EPHX1) is a critical biotransformation enzyme and participants in both the detoxification and activation of potentially genotoxic epoxides. In this study, we firstly aimed to investigate the role of EPHX1 in the chemoresistance of acute myeloid leukemic cells to aclarubicin (ACM) and mitoxantrone (MIT). EPHX1 mRNA expression and prognosis were measured in acute myeloid leukemia (AML) patients, and the function of EPHX1 in leukemic cell viability and apoptosis induced by ACM and MIT was also measured. Read More

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http://doi.wiley.com/10.1002/mc.22973
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http://dx.doi.org/10.1002/mc.22973DOI Listing
January 2019
9 Reads

No difference in 4-nitroquinoline induced tumorigenesis between germ-free and colonized mice.

Mol Carcinog 2019 Jan 10. Epub 2019 Jan 10.

Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California.

Variations in oral bacterial communities have been linked to oral cancer suggesting that the oral microbiome is an etiological factor that can influence oral cancer development. The 4-nitroquinoline 1-oxide (4-NQO)-induced murine oral and esophageal cancer model is frequently used to assess the effects of preventive and/or therapeutic agents. We used this model to assess the impact of the microbiome on tumorigenesis using axenic (germ-free) and conventionally housed mice. Read More

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http://dx.doi.org/10.1002/mc.22972DOI Listing
January 2019
2 Reads

Core fucosylation of copper transporter 1 plays a crucial role in cisplatin-resistance of epithelial ovarian cancer by regulating drug uptake.

Mol Carcinog 2019 Jan 5. Epub 2019 Jan 5.

College of Basic Medical Sciences, Dalian Medical University, Liaoning, China.

Core fucosylation catalyzed by core fucosyltransferase (Fut8) contributes to the progressions of epithelial ovarian cancer (EOC). Copper transporter 1 (CTR1), which contains one N-glycan on Asn , mediates cellular transport of cisplatin (cDDP), and plays an important role in the process of cDDP-resistance in EOC. In the present study, we found that the core fucosylation level elevated significantly in the sera of cDDP-treated EOC patients. Read More

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http://doi.wiley.com/10.1002/mc.22971
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http://dx.doi.org/10.1002/mc.22971DOI Listing
January 2019
14 Reads

A functional variant rs1537373 in 9p21.3 region is associated with pancreatic cancer risk.

Mol Carcinog 2019 Jan 3. Epub 2019 Jan 3.

Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

9p21.3 has been identified as an unexpected hot point in multiple diseases GWAS including cancers, and we performed a two-stage case-control studies integrating functional assay strategy to find the potential functional variants modified susceptibility to pancreatic cancer (PC). An expanded Illumina HumanExome Beadchip of PC including 943 cases and 3908 controls was used to examine 39 tagSNPs in 9p21. Read More

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http://doi.wiley.com/10.1002/mc.22968
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http://dx.doi.org/10.1002/mc.22968DOI Listing
January 2019
4 Reads
4.808 Impact Factor

TIMM50 promotes tumor progression via ERK signaling and predicts poor prognosis of non-small cell lung cancer patients.

Mol Carcinog 2019 Jan 3. Epub 2019 Jan 3.

Department of Pathology, College of Basic Medical Science and the First Affiliated Hospital of China Medical University, Shenyang, China.

TIMM50 (Translocase of the inner mitochondrial membrane 50), also called TIM50, plays an essential role in mitochondrial membrane transportation. The existing literature suggests that TIMM50 may perform as an oncogenetic protein in breast cancer. However, the molecular mechanism, especially in human non-small cell lung cancer (NSCLC), is uncertain to date. Read More

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http://dx.doi.org/10.1002/mc.22969DOI Listing
January 2019
2 Reads

NFκB2 p52 stabilizes rhogdiβ mRNA by inhibiting AUF1 protein degradation via a miR-145/Sp1/USP8-dependent axis.

Mol Carcinog 2019 Jan 3. Epub 2019 Jan 3.

Nelson Institute of Environmental Medicine, New York University, School of Medicine, New York, New York.

Although overexpression of the non-canonical NFκB subunit p52 has been observed in several tumors, the function and mechanism of p52 in bladder cancer (BC) are less well understood. Here, we aimed at understanding the role and mechanism underlying p52 regulation of BC invasion. Human p52 was stably knockdown with shRNA targeting p52 in two bladder cancer cell lines (T24 and UMUC3). Read More

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http://doi.wiley.com/10.1002/mc.22970
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http://dx.doi.org/10.1002/mc.22970DOI Listing
January 2019
5 Reads
4.808 Impact Factor

GRB7 dependent proliferation of basal-like, HER-2 positive human breast cancer cell lines is mediated in part by HER-1 signaling.

Mol Carcinog 2019 Jan 3. Epub 2019 Jan 3.

Veterans Administration Portland Health Care System, Portland, Oregon.

GRB7 gene encodes a multi-domain signal transduction molecule and is part of the core of the HER-2 amplicon. GRB7 is commonly co-amplified and overexpressed with HER-2 in human breast cancer. This study addresses the role of GRB7 in HER-2 positive human breast cancers resistant to HER-2 targeted therapy. Read More

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http://dx.doi.org/10.1002/mc.22963DOI Listing
January 2019
2 Reads

Exosomal protein CD82 as a diagnostic biomarker for precision medicine for breast cancer.

Mol Carcinog 2019 Jan 3. Epub 2019 Jan 3.

Department of Clinical Laboratory, Second Affiliated Hospital of Dalian Medical University, Dalian, China.

CD82, a member of the tetraspanin superfamily, has been proposed to exert its activity via tetra-transmembrane protein enriched microdomains (TEMs) in exosomes. The present study aimed to explore the potential of the exosome protein CD82 in diagnosing breast cancers of all stages and various histological subtypes in patients. The results strongly suggest that CD82 expression in breast cancer tissue was significantly lower than that in healthy and benign breast disease tissues. Read More

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http://doi.wiley.com/10.1002/mc.22960
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http://dx.doi.org/10.1002/mc.22960DOI Listing
January 2019
7 Reads

Metabolic profiling analysis upon acylcarnitines in tissues of hepatocellular carcinoma revealed the inhibited carnitine shuttle system caused by the downregulated carnitine palmitoyltransferase 2.

Mol Carcinog 2019 Jan 3. Epub 2019 Jan 3.

School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.

The carnitine shuttle system (CSS) plays a crucial role in the transportation of fatty acyls during fatty acid β-oxidation for energy supplementation, especially in cases of high energy demand, such as in cancer. In this study, to systematically characterize alterations of the CSS in hepatocellular carcinoma (HCC), acylcarnitine metabolic profiling was carried out on 80 pairs of HCC tissues and adjacent noncancerous tissues (ANTs) by using ultra-performance liquid chromatography coupled to mass spectrometry. Twenty-four acylcarnitines classified into five categories were identified and characterized between HCCs and ANTs. Read More

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http://dx.doi.org/10.1002/mc.22967DOI Listing
January 2019
3 Reads

Corrigendum.

Authors:

Mol Carcinog 2019 Feb 25;58(2):305. Epub 2018 Oct 25.

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http://dx.doi.org/10.1002/mc.22927DOI Listing
February 2019
1 Read

cd44 deletion suppresses atypia in the precancerous mouse testis.

Mol Carcinog 2018 Dec 23. Epub 2018 Dec 23.

Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.

Loss-of-function of RHAMM causes hypofertility and testicular atrophy in young mice, followed by germ cell neoplasia in situ (GCNIS) of the testis, cellular atypia, and development of the testicular germ cell tumor (TGCT) seminoma. These pathologies reflect the risk factors and phenotypes that precede seminoma development in humans and-given the high prevalence of RHAMM downregulation in human seminoma-link RHAMM dysfunction with the aetiology of male hypofertility and GCNIS-related TGCTs. The initiating event underlying these pathologies, in RHAMM mutant testis, is premature displacement of undifferentiated progenitors from the basal compartment. Read More

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http://dx.doi.org/10.1002/mc.22961DOI Listing
December 2018
4 Reads

Ectopic expression of PLC-β2 in non-invasive breast tumor cells plays a protective role against malignant progression and is correlated with the deregulation of miR-146a.

Mol Carcinog 2018 Dec 23. Epub 2018 Dec 23.

Section of Anatomy and Histology, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.

Cells in non-invasive breast lesions are widely believed to possess molecular alterations that render them either susceptible or refractory to the acquisition of invasive capability. One such alteration could be the ectopic expression of the β2 isoform of phosphoinositide-dependent phospholipase C (PLC-β2), known to counteract the effects of hypoxia in low-invasive breast tumor-derived cells. Here, we studied the correlation between PLC-β2 levels and the propensity of non-invasive breast tumor cells to acquire malignant features. Read More

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http://dx.doi.org/10.1002/mc.22964DOI Listing
December 2018
2 Reads

Morin-dependent inhibition of low molecular weight protein tyrosine phosphatase (LMW-PTP) restores sensitivity to apoptosis during colon carcinogenesis: Studies in vitro and in vivo, in an Apc-driven model of colon cancer.

Mol Carcinog 2018 Dec 23. Epub 2018 Dec 23.

NEUROFARBA Department, Section of Pharmacology and Toxicology, University of Florence, Florence, Italy.

LMW-PTP has been associated with the development of colorectal cancer (CRC) and with the resistance to chemotherapy in cancer cells. To clarify its role in vivo, we studied LMW-PTP expression in Pirc rats (F344/NTac-Apc ), genetically prone to CRC and resistant to apoptosis. In the morphologically normal mucosa (NM) of Pirc rats, a dramatic over-expression of LMW-PTP was found compared to wt rats (about 60 times higher). Read More

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http://dx.doi.org/10.1002/mc.22962DOI Listing
December 2018
1 Read

POLR1D promotes colorectal cancer progression and predicts poor prognosis of patients.

Mol Carcinog 2018 Dec 23. Epub 2018 Dec 23.

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.

RNA polymerase I subunit D (POLR1D), which is involved in synthesis of ribosomal RNA precursors and small RNAs, has been shown to be overexpressed in several human cancer types. Nevertheless, the role of POLR1D in the progression of colorectal cancer (CRC) remains unknown. The following study aimed to investigate the role and underlying mechanism of POLR1D in CRC progression. Read More

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http://doi.wiley.com/10.1002/mc.22966
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http://dx.doi.org/10.1002/mc.22966DOI Listing
December 2018
13 Reads

Camphor white oil induces tumor regression through cytotoxic T cell-dependent mechanisms.

Mol Carcinog 2018 Dec 23. Epub 2018 Dec 23.

Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, New York.

Bioactive derivatives from the camphor laurel tree, Cinnamomum camphora, are posited to exhibit chemopreventive properties but the efficacy and mechanism of these natural products are not fully understood. We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity in a mouse model of keratinocyte-derived skin cancer. Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. Read More

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http://dx.doi.org/10.1002/mc.22965DOI Listing
December 2018
10 Reads

Inter- and intra-tumor heterogeneity of SMAD4 loss in head and neck squamous cell carcinomas.

Mol Carcinog 2018 Dec 21. Epub 2018 Dec 21.

Department of Pathology, School of Medicine, Molecular Biology Program, Medical Scientist Training Program, University of Colorado, Aurora, Colorado.

Reports regarding the frequency of SMAD4 loss in human head and neck squamous cell carcinoma (HNSCC) vary significantly. We have shown that SMAD4 deletion contributes to HNSCC initiation and progression. Therefore, accurately detecting genetic SMAD4 loss is critical to determine prognosis and therapeutic interventions in personalized medicine. Read More

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http://dx.doi.org/10.1002/mc.22958DOI Listing
December 2018
3 Reads
4.808 Impact Factor

Intermittent hypoxia promotes carcinogenesis in azoxymethane and dextran sodium sulfate-induced colon cancer model.

Mol Carcinog 2018 Dec 21. Epub 2018 Dec 21.

Obstructive Upper airway Research (OUaR) Laboratory, Department of Pharmacology, Seoul National University College of Medicine, Seoul, Korea.

Intermittent hypoxia (IH), a characteristic of obstructive sleep apnea, is known to promote cancer progression and aggressiveness in mouse models. However, little is known regarding the effect of IH on cancer initiation. Here, the effect of IH on carcinogenesis was explored in azoxymethane (AOM) and dextran sodium sulfate (DSS)-induced colon cancer models with three different protocols. Read More

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http://dx.doi.org/10.1002/mc.22957DOI Listing
December 2018
2 Reads

APOBEC3B promotes hepatocarcinogenesis and metastasis through novel deaminase-independent activity.

Mol Carcinog 2018 Dec 21. Epub 2018 Dec 21.

Department of Pathology, The University of Hong Kong, Pokfulam, Hong Kong.

Cytidine deaminase APOBEC3B (A3B) is known to play important roles in creating de novo genomic C-to-T mutations in cancers and contribute to induction of genomic instability. Our study evaluated the roles of A3B in the progression and metastasis of human hepatocellular carcinoma (HCC). Using whole-transcriptome and whole-exome sequencing, and quantitative PCR, we found that A3B was overexpressed in human HCCs and A3B expression was significantly correlated with the proportion of genomic C-to-A and G-to-T mutations. Read More

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http://dx.doi.org/10.1002/mc.22956DOI Listing
December 2018
2 Reads

Linc00161 regulated the drug resistance of ovarian cancer by sponging microRNA-128 and modulating MAPK1.

Mol Carcinog 2018 Dec 17. Epub 2018 Dec 17.

Department of Gynecology and Obstetrics, Jiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of TCM, Nanjing, Jiangsu, China.

This study aimed to investigate the regulatory mechanism of linc00161/miR-128/MAPK1 axis on drug resistance of ovarian cancer. Methods: the differentially expressed lncRNAs were screened based on microarray analysis. The expression of linc00161, miR-128 and MAPK1 in ovarian cancer-resistant tissues and cells was tested qRT-PCR, whereas MAPK1 protein expression was examined via western blot in the ovarian cancer resistant cells. Read More

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http://dx.doi.org/10.1002/mc.22952DOI Listing
December 2018
1 Read
4.808 Impact Factor

SNP-SNP and SNP-environment interactions of potentially functional HOTAIR SNPs modify the risk of hepatocellular carcinoma.

Mol Carcinog 2018 Dec 17. Epub 2018 Dec 17.

Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.

HOX transcript antisense intergenic RNA (HOTAIR) has been widely regarded as a functional lncRNA contributing to multiple cancers. However, few studies have examined the effect of single nucleotide polymorphisms (SNPs) in HOTAIR on the occurrence and development of hepatocellular carcinoma (HCC). In this study, three potentially functional HOTAIR SNPs (rs17105613, rs12427129, and rs3816153) were selected using bioinformatic tools. Read More

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http://dx.doi.org/10.1002/mc.22955DOI Listing
December 2018
2 Reads

Uridine-cytidine kinase 2 upregulation predicts poor prognosis of hepatocellular carcinoma and is associated with cancer aggressiveness.

Mol Carcinog 2018 Dec 17. Epub 2018 Dec 17.

Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

Patients with advanced hepatocellular carcinoma (HCC) continue to have a dismal prognosis. Potential biomarkers to determine prognosis and select targeted therapies are urgently needed for patients with HCC. This study aimed to elucidate the role of UCK2 in HCC prognosis and tumor progression. Read More

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http://dx.doi.org/10.1002/mc.22954DOI Listing
December 2018
3 Reads

Whole-exome sequencing reveals novel genetic variants associated with diverse phenotypes of melanoma cells.

Mol Carcinog 2018 Dec 17. Epub 2018 Dec 17.

Department of Molecular Biology of Cancer, Medical University of Lodz, Lodz, Poland.

We have extensively studied the phenotypic heterogeneity of patient-derived melanoma cells. Here, whole-exome sequencing revealed novel variants of genes associated with the MAPK, NOTCH, Hippo, cell-cycle, senescence, and ubiquitin-dependent pathways, which could contribute to the observed phenotypic diversity between cell lines. Focusing on mutations in the MAPK pathway-associated genes, we found BRAF (BRAF ) and RAS subtypes, including NRAS and the rare HRAS variant, and additional alterations potentially leading to different ERK1/2 activity. Read More

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http://doi.wiley.com/10.1002/mc.22953
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http://dx.doi.org/10.1002/mc.22953DOI Listing
December 2018
2 Reads

TMEM196 hypermethylation as a novel diagnostic and prognostic biomarker for lung cancer.

Mol Carcinog 2018 Dec 11. Epub 2018 Dec 11.

Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, PR China.

Emerging evidences have revealed tumor-specific gene methylation is considered to be a promising non-invasive biomarker for many different types of cancers. This study was determined whether TMEM196 gene hypermethylation and downregulation are considered to be promising biomarkers for early diagnosis and prognosis in lung cancer. Methylation status was detected with methylation-specific PCR. Read More

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http://dx.doi.org/10.1002/mc.22942DOI Listing
December 2018
1 Read

hsa_circRNA_0006528 as a competing endogenous RNA promotes human breast cancer progression by sponging miR-7-5p and activating the MAPK/ERK signaling pathway.

Mol Carcinog 2018 Dec 5. Epub 2018 Dec 5.

Oncology Institute, Affiliated Hospital of Jiangnan University, Wuxi, China.

Emerging research has indicated that circular RNAs (circRNAs), a novel class of non-coding RNAs, play a vital role in human tumorigenesis and progression. Our previous results suggested that hsa_circ_0006528 (circ_0006528), a circRNA with an unknown function, mediates adriamycin resistance in human breast cancer cells. However, the role of circ_0006528 in breast cancer progression remains unknown. Read More

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http://dx.doi.org/10.1002/mc.22950DOI Listing
December 2018
2 Reads

Immune associated LncRNAs identify novel prognostic subtypes of renal clear cell carcinoma.

Mol Carcinog 2018 Dec 5. Epub 2018 Dec 5.

Department of Biosciences and Bioengineering, Indian Institute of Technology Dharwad, Dharwad, Karnataka.

Kidney Renal Clear Cell Carcinoma (KIRC) is a significant cause of cancer-related deaths. Here, we aim to identify the LncRNAs associated with the immune system and characterise their clinical utility in KIRC. A total of 504 patients' data was used from TCGA-GDC. Read More

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http://doi.wiley.com/10.1002/mc.22949
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http://dx.doi.org/10.1002/mc.22949DOI Listing
December 2018
23 Reads
4.808 Impact Factor

Alantolactone sensitizes human pancreatic cancer cells to EGFR inhibitors through the inhibition of STAT3 signaling.

Mol Carcinog 2018 Dec 5. Epub 2018 Dec 5.

Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Several studies have implicated the feedback activation of signal transducer and activator of transcription 3 (STAT3) as a new cancer drug-resistance mechanism and linked it to the failure of epidermal growth factor receptor (EGFR)-targeted therapies. In this study, we discovered that Alantolactone, a natural sesquiterpene lactone, potently inhibited human pancreatic cancer cells and suppressed constitutively activated STAT3. In contrast, Alantolactone had little effect on the EGFR pathway. Read More

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http://dx.doi.org/10.1002/mc.22951DOI Listing
December 2018
2 Reads

Butyrate inhibits HBV replication and HBV-induced hepatoma cell proliferation via modulating SIRT-1/Ac-p53 regulatory axis.

Mol Carcinog 2018 Nov 30. Epub 2018 Nov 30.

Molecular Medicine Laboratory, Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi, India.

Butyrate, a histone deacetylase inhibitor, has several therapeutic applications, including cancer. However, the effect of butyrate in HBV replication is not known so far. It was hypothesized that butyrate might inhibit HBV replication and host cell proliferation via SIRT-1. Read More

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http://dx.doi.org/10.1002/mc.22946DOI Listing
November 2018
2 Reads
4.808 Impact Factor

Effects of vitamin D and calcium on expression of MSH2 and transforming growth factors in normal-appearing colorectal mucosa of sporadic colorectal adenoma patients: A randomized clinical trial.

Mol Carcinog 2018 Nov 30. Epub 2018 Nov 30.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.

Abnormal expression of the DNA mismatch repair protein MSH2 and autocrine/paracrine transforming growth factors TGFα (growth promoter) and TGFβ (growth inhibitor) is common during colorectal carcinogenesis. To estimate vitamin D and calcium effects on these biomarkers in the normal-appearing colorectal mucosa of sporadic colorectal adenoma patients, we conducted a pilot, randomized, double-blinded, placebo-controlled, modified 2 × 2 factorial chemoprevention clinical trial (N = 104) of supplemental vitamin D (1000 IU daily) and calcium (1200 mg daily), alone and in combination, versus placebo over 1 year. The expression of the three biomarkers and Ki-67/mib-1 in colorectal crypts in biopsies of normal-appearing rectal mucosa were detected using automated immunohistochemistry and quantified using image analysis. Read More

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http://dx.doi.org/10.1002/mc.22945DOI Listing
November 2018
2 Reads

Clonality and heterogeneity of metachronous colorectal cancer.

Mol Carcinog 2019 Mar 16;58(3):447-457. Epub 2018 Dec 16.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery IV, Peking University Cancer Hospital & Institute, Beijing, China.

Patients with metachronous colorectal cancer (CRC) have been diagnosed with primary CRC more than once. Given that the genetic and microenvironment is the same in these cases, metachronous CRC is an important model for studying colorectal tumorigenesis. We performed whole exome sequencing of seven freshly frozen tumors from three patients with metachronous CRC and compared their genetic profiles. Read More

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http://dx.doi.org/10.1002/mc.22947DOI Listing
March 2019
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Ethyl gallate as a novel ERK1/2 inhibitor suppresses patient-derived esophageal tumor growth.

Mol Carcinog 2018 Nov 30. Epub 2018 Nov 30.

China-US (Henan) Hormel Cancer Institute, Henan, China.

Ethyl gallate (EG) is a phenolic compound that is isolated from walnut kernels, euphorbia fischeriana, and galla rhois. It has been reported to exhibit antioxidant and anticancer activities. However, EG's effects on esophageal cancer have not yet been investigated. Read More

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http://doi.wiley.com/10.1002/mc.22948
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http://dx.doi.org/10.1002/mc.22948DOI Listing
November 2018
17 Reads

Lymphotoxin-β receptor-NIK signaling induces alternative RELB/NF-κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer.

Mol Carcinog 2019 Mar 28;58(3):411-425. Epub 2018 Nov 28.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.

Head and neck squamous cell carcinomas (HNSCC) preferentially spread to regional cervical tissues and lymph nodes. Here, we hypothesized that lymphotoxin-β (LTβ), receptor LTβR, and NF-κB-inducing kinase (NIK), promote the aberrant activation of alternative NF-κB2/RELB pathway and genes, that enhance migration and invasion of HNSCC. Genomic and expression alterations of the alternative NF-kB pathway were examined in 279 HNSCC tumors from The Cancer Genome Atlas (TCGA) and a panel of HNSCC lines. Read More

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http://doi.wiley.com/10.1002/mc.22938
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http://dx.doi.org/10.1002/mc.22938DOI Listing
March 2019
5 Reads

PPP3CB contributes to poor prognosis through activating nuclear factor of activated T-cells signaling in neuroblastoma.

Mol Carcinog 2019 Mar 13;58(3):426-435. Epub 2018 Dec 13.

Chiba Cancer Center Research Institute, Chiba, Japan.

We previously identified a gain-of-function mutation in PPP3CB in a neuroblastoma (NB) with MYCN amplification. Here we investigated the functional and clinical role of PPP3CB in NB. High PPP3CB expression was an independent indicator predicting poor prognosis of NB. Read More

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http://dx.doi.org/10.1002/mc.22939DOI Listing
March 2019
2 Reads

Genetic polymorphisms of diabetes-related genes, their interaction with diabetes status, and breast cancer incidence and mortality: The Long Island Breast Cancer Study Project.

Mol Carcinog 2019 Mar 11;58(3):436-446. Epub 2018 Dec 11.

Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

To examine 143 diabetes risk single nucleotide polymorphisms (SNPs), identified from genome-wide association studies, in association with breast cancer (BC) incidence and subsequent mortality. A population-based sample of Caucasian women with first primary invasive BC (n = 817) and controls (n = 1021) were interviewed to assess diabetes status. Using the National Death Index, women with BC were followed for >18 years during which 340 deaths occurred (139 BC deaths). Read More

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http://doi.wiley.com/10.1002/mc.22940
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http://dx.doi.org/10.1002/mc.22940DOI Listing
March 2019
17 Reads