391 results match your criteria Molecular Targets in the Treatment of Head and Neck Squamous Cell Carcinoma


Immunohistochemical analysis and correlation of cyclooxygenase-2 expression status with clinicopathological parameters in head and neck squamous cell carcinomas: An Indian perspective.

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):583. Epub 2021 Jan 9.

Department of Laboratory Medicine, Command Hospital (Central Command), Lucknow, Uttar Pradesh, India.

Context: Head and neck squamous cell carcinoma (HNSCC) poses a major health problem and despite the advancements in its diagnosis and management the overall survival has not improved significantly. A search for newer diagnostic and prognostic markers along with fresh molecular targets is required for its prevention and cure.

Aims: The study aims to study the expression of cyclooxygenase-2 (COX-2) in HNSCCs and investigate its correlation with the clinicopathological profile of these cases. Read More

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January 2021

Bioinformatics analysis of laryngeal squamous cell carcinoma: seeking key candidate genes and pathways.

PeerJ 2021 14;9:e11259. Epub 2021 Apr 14.

Department of Otolaryngology, Cangzhou Central Hospital, Cangzhou, Hebei, China.

Background: Laryngeal squamous cell carcinoma (LSCC) is the second most aggressive head and neck squamous cell carcinoma. Although much work has been done to optimize its treatment, patients with LSCC still have poor prognosis. Therefore, figuring out differentially expressed genes (DEGs) contained in the progression of LSCC and employing them as potential therapeutic targets or biomarkers for LSCC is extremely meaningful. Read More

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Melatonin Targets Metabolism in Head and Neck Cancer Cells by Regulating Mitochondrial Structure and Function.

Antioxidants (Basel) 2021 Apr 14;10(4). Epub 2021 Apr 14.

Biomedical Research Center, Health Sciences Technology Park, University of Granada, 18016 Granada, Spain.

Metabolic reprogramming, which is characteristic of cancer cells that rapidly adapt to the hypoxic microenvironment and is crucial for tumor growth and metastasis, is recognized as one of the major mechanisms underlying therapeutic resistance. Mitochondria, which are directly involved in metabolic reprogramming, are used to design novel mitochondria-targeted anticancer agents. Despite being targeted by melatonin, the functional role of mitochondria in melatonin's oncostatic activity remains unclear. Read More

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Long non-coding RNAs in head and neck squamous cell carcinoma: Diagnostic biomarkers, targeted therapies, and prognostic roles.

Eur J Pharmacol 2021 Apr 23;902:174114. Epub 2021 Apr 23.

Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China. Electronic address:

At present, emerging evidence shows that non-coding RNAs (ncRNAs) play crucial roles for development of multiple tumors. Amongst these ncRNAs, long non-coding RNAs (lncRNAs) play prominent roles in physiological and pathological processes. LncRNAs are RNA transcripts larger than 200 nucleotides and have been shown to serve important regulatory roles in different types of cancer via interactions with DNA, RNA and proteins. Read More

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LINC00460 Promotes Cell Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition of Head and Neck Squamous Cell Carcinoma via miR-320a/BGN Axis.

Onco Targets Ther 2021 30;14:2279-2291. Epub 2021 Mar 30.

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, People's Republic of China.

Purpose: Long non-coding RNAs (lncRNAs) play critical roles in cancer onset and development, including head and neck squamous cell carcinoma (HNSCC). This study aimed to investigate the biological role of LINC00460 and the mechanisms underlying epithelial-mesenchymal transition (EMT) in HNSCC.

Methods: Aberrantly LINC00460 expression in HNSCC and overall survival outcomes were constructed using the TCGA database. Read More

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MiRNA expression profiling and emergence of new prognostic signature for oral squamous cell carcinoma.

Sci Rep 2021 Mar 31;11(1):7298. Epub 2021 Mar 31.

Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, Kerala, 695011, India.

Oral squamous cell carcinoma (OSCC), the most common type of head and neck cancers, is associated with high recurrence, metastasis, low long-term survival rates and poor treatment outcome. As deregulated miRNA expression plays a crucial role in malignant transformation and cancer progression, the present study is aimed at profiling the miRNA expression pattern in OSCC and developing a new miRNA prognostic signature for oral cancer. MiRNA expression profiling was performed using MiRNA microarray in 30 tumor and 18 normal samples. Read More

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Comprehensive analysis of radiosensitivity in head and neck squamous cell carcinoma.

Radiother Oncol 2021 Mar 26;159:126-135. Epub 2021 Mar 26.

Department of Radiation Oncology, The First Hospital of China Medical University, Shenyang, China. Electronic address:

Background: Radioresistance is a major barrier to the successful treatment of head and neck squamous cell carcinoma (HNSCC).

Methods: We took advantage of different types of data, including single-cell sequencing data, bulk tissue sequencing data and deconvolution data, to conduct a comprehensive analysis of HNSCC radiosensitivity at the cellular, patient, and cell type levels. Single-cell transcriptomes for 1388 primary cancer cells from a previous study were analysed. Read More

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Oxygen Deprivation Modulates EGFR and PD-L1 in Squamous Cell Carcinomas of the Head and Neck.

Front Oncol 2021 26;11:623964. Epub 2021 Feb 26.

Department of Radiation Oncology and Radiation Therapy, University Medical Center Mainz, Mainz, Germany.

Abundance and signaling of the epidermal growth factor receptor (EGFR) and programmed cell death protein ligand 1 (PD-L1) in head and neck squamous cell carcinoma (HNSCC) are not only genetically determined but are also subject to the traits of the tumor microenvironment, which has hitherto not been clarified completely. We investigated the impact of hypoxia on the EGFR system and on PD-L1 in six HPV negative HNSCC cell lines and in FaDu xenografts . Protein levels of EGFR, AKT, pAKT, ERK1/2, pERK1/2, CA IX, cleaved PARP (apoptosis), LC3B (autophagy), and PD-L1 were quantified by western blot after oxygen deprivation or CoCl, staurosporine, and erlotinib treatment. Read More

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February 2021

Six Glycolysis-Related Genes as Prognostic Risk Markers Can Predict the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma.

Biomed Res Int 2021 10;2021:8824195. Epub 2021 Feb 10.

Otolaryngology & Head and Neck Surgery, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region, China.

Objective: Head and neck squamous cell carcinoma (HNSCC) is one of the worst-prognosis malignant tumors. This study used bioinformatic analysis of the transcriptome sequencing data of HNSCC and the patients' survival and clinical data to construct a prediction signature of glycolysis-related genes as the prognostic risk markers.

Methods: Gene expression profile data about HNSCC tissues ( = 498) and normal tissues in the head and neck ( = 44) were got from The Cancer Genome Atlas (TCGA), as well as patients' survival and clinical data. Read More

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February 2021

Identification of four genes and biological characteristics of esophageal squamous cell carcinoma by integrated bioinformatics analysis.

Cancer Cell Int 2021 Feb 18;21(1):123. Epub 2021 Feb 18.

Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.

Background: Esophageal squamous cell carcinoma (ESCC) has become one of the most serious diseases affecting populations worldwide and is the primary subtype of esophageal cancer (EC). However, the molecular mechanisms governing the development of ESCC have not been fully elucidated.

Methods: The robust rank aggregation method was performed to identify the differentially expressed genes (DEGs) in six datasets (GSE17351, GSE20347, GSE23400, GSE26886, GSE38129 and GSE77861) from the Gene Expression Omnibus (GEO). Read More

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February 2021

Whole-exome Sequencing in Penile Squamous Cell Carcinoma Uncovers Novel Prognostic Categorization and Drug Targets Similar to Head and Neck Squamous Cell Carcinoma.

Clin Cancer Res 2021 May 13;27(9):2560-2570. Epub 2021 Jan 13.

The University of Texas MD Anderson Cancer Center, Houston, Texas.

Purpose: Penile squamous cell carcinoma (PSCC) is rare with limited treatment options. We report the first whole-exome sequencing (WES) analysis and compare the molecular landscape of PSCC with other squamous cell carcinomas (SCC), with the goal to identify common novel targets.

Experimental Design: PSCC and matched normal penile tissues from 34 prospectively followed patients, underwent genomic WES and human papilloma virus testing. Read More

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Overexpression of LncRNA Were Suitable for Oncolytic Adenoviruse H101 Therapy in Oral Squamous-Cell Carcinoma.

Onco Targets Ther 2020 21;13:13033-13039. Epub 2020 Dec 21.

Department of Outpatient Stomatology, Heilongjiang Provincial Hospital, Harbin 150036, Heilongjiang, People's Republic of China.

Background: As the most prevalent type of head and neck cancer, oral squamous-cell carcinoma (OSCC) accounts for nearly 90% of all oral cancer cases. Despite great progress having been made in the diagnosis and treatment of OSCC recently, the survival rate of OSCC patients has not risen remarkably. Chemotherapy is commonly used for OSCC treatment; however, the emergence of chemoresistance limits its long-term curative effect. Read More

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December 2020

Expression and Possible Molecular Mechanisms of microRNA-205-5p in Patients With Head and Neck Squamous Cell Carcinoma.

Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820980110

Department of Radiation Oncology, 117742The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.

Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignancy worldwide, with high incidence and poor survival rates. Increased expression of microRNA-205-5p (miR-205-5p) may influence the outcomes of HNSCC, but the identities of miR-205-5p target genes and the potential signaling pathways related to HNSCC remain unclear. RT-qPCR was used to detect the expression levels of miR-205-5p in the plasma of patients with HNSCC. Read More

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December 2020

H19/miR-107/HMGB1 axis sensitizes laryngeal squamous cell carcinoma to cisplatin by suppressing autophagy in vitro and in vivo.

Cell Biol Int 2021 Mar 31;45(3):674-685. Epub 2020 Dec 31.

Department of Otolaryngology Head and Neck Surgery, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan, China.

Laryngeal squamous cell carcinoma (LSCC) is the most common malignant tumor, which occurs in the head and neck. Current treatments for LSCC are all largely weakened by increasing drug resistance. Our study aimed to investigate the effects of long noncoding RNA (lncRNA) H19 on drug resistance in LSCC. Read More

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AKR1C3 is a biomarker and druggable target for oropharyngeal tumors.

Cell Oncol (Dordr) 2021 Apr 19;44(2):357-372. Epub 2020 Nov 19.

Laboratory of Cancer Genomics, Fondazione Edo ed Elvo Tempia, via Malta 3, 13900, Biella, Italy.

Purpose: Oropharynx squamous cell carcinoma (OPSCC) is a subtype of head and neck squamous cell carcinoma (HNSCC) arising from the base of the tongue, lingual tonsils, tonsils, oropharynx or pharynx. The majority of HPV-positive OPSCCs has a good prognosis, but a fraction of them has a poor prognosis, similar to HPV-negative OPSCCs. An in-depth understanding of the molecular mechanisms underlying OPSCC is mandatory for the identification of novel prognostic biomarkers and/or novel therapeutic targets. Read More

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Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth.

Front Genet 2020 10;11:1036. Epub 2020 Sep 10.

Department of Radiation Oncology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, United States.

Novel targeted agents to inhibit DNA repair pathways to sensitize tumors to irradiation (IR) are being investigated as an alternative to chemoradiation for locally advanced human papilloma virus negative (HPV-negative) head and neck squamous cell carcinoma (HNSCC). Two well-characterized targets that, when inhibited, exhibit potent IR sensitization are PARP1 and DNA-PKcs. However, their cooperation in sensitizing HPV-negative HNSCC to IR remains to be explored given that PARP1 and DNA-Pk bind to unresected stalled DNA replication forks and cooperate to recruit XRCC1 to facilitate double-strand break repair. Read More

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September 2020

HPV oral-tongue cancer stem cells: A potential target for relapse-free therapy.

Transl Oncol 2021 Jan 24;14(1):100919. Epub 2020 Oct 24.

Stem Cell and Cancer Research Lab, Amity Institute of Molecular Medicine & Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Sector-125, Noida 201313, India. Electronic address:

The tongue squamous cell carcinoma (TSCC) is a highly prevalent head and neck cancer often associated with tobacco and/or alcohol abuse or high-risk human papillomavirus (HR-HPV) infection. HPV positive TSCCs present a unique mechanism of tumorigenesis as compared to tobacco and alcohol-induced TSCCs and show a better prognosis when treated. The poor prognosis and/or recurrence of TSCC is due to presence of a small subpopulation of tumor-initiating tongue cancer stem cells (TCSCs) that are intrinsically resistant to conventional chemoradio-therapies enabling cancer to relapse. Read More

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January 2021

Role of Focal Adhesion Kinase in Head and Neck Squamous Cell Carcinoma and Its Therapeutic Prospect.

Onco Targets Ther 2020 9;13:10207-10220. Epub 2020 Oct 9.

Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.

Head and neck cancers are one of the most prevalent cancers globally. Among them, head and neck squamous cell carcinoma (HNSCC) accounts for approximately 90% of head and neck cancers, which occurs in the oral cavity, oral pharynx, hypopharynx and larynx. The 5-year survival rate of HNSCC patients is only 63%, mainly because about 80-90% of patients with advanced HNSCC tend to suffer from local recurrence or even distant metastasis. Read More

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October 2020

Upfront dose-reduced chemotherapy synergizes with immunotherapy to optimize chemoimmunotherapy in squamous cell lung carcinoma.

J Immunother Cancer 2020 10;8(2)

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

Background: The survival benefits of combining chemotherapy (at the maximum tolerated dose, MTD) with concurrent immunotherapy, collectively referred to as chemoimmunotherapy, for the treatment of squamous cell lung carcinoma (SQCLC) have been confirmed in recent clinical trials. Nevertheless, optimization of chemoimmunotherapy in order to enhance the efficacy of immune checkpoint inhibitors (ICIs) in SQCLC remains to be explored.

Methods: Cell lines, syngeneic immunocompetent mouse models, and patients' peripheral blood mononuclear cells were used in order to comprehensively explore how to enhance ectopic lymphoid-like structures (ELSs) and upregulate the therapeutic targets of anti-programmed death 1 (PD-1)/anti-PD-1 ligand (PD-L1) monoclonal antibodies (mAbs), thus rendering SQCLC more sensitive to ICIs. Read More

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October 2020

Long Noncoding RNA Promotes the Progression of Liver Cancer via Alteration of microRNA-144-3p/DOCK4 Signal.

Cancer Manag Res 2020 29;12:9339-9349. Epub 2020 Sep 29.

Department of Pediatric Neurology, First Hospital of Jilin University, Changchun, Jilin 130012, People's Republic of China.

Background: Therapy for patients with liver cancer in the advanced stage remains a great challenge, and there are very few approved treatments. Although accumulated evidence demonstrates the importance of lncRNAs in liver cancer, data on the functional roles and molecular mechanisms of endogenous bornavirus-like nucleoprotein () have been rarely reported.

Materials And Methods: The bioinformatics prediction software ENCORI was used to predict the putative binding sites of . Read More

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September 2020

Mechanisms of resistance in head and neck cancer.

Am J Cancer Res 2020 1;10(9):2742-2751. Epub 2020 Sep 1.

Division of Hematology/Oncology, Georgia Cancer Center, Augusta University Augusta, GA 30909, USA.

Resistance to treatment is one of the biggest challenges in combating head and neck squamous cell carcinoma (HNSCC). The concept of resistance, however, is often viewed as a whole without categorization into the two types of resistance: acquired and intrinsic. Comparison of the mechanisms of the two types of resistance can give further insight as to the importance of these resistance pathways, as mechanisms that are common between the two categories are more likely to be integral to cell survival. Read More

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September 2020

Notch in Head and Neck Cancer.

Adv Exp Med Biol 2021 ;1287:81-103

Institute of Oral Biology, Orofacial Development and Regeneration, University of Zurich, Zurich, Switzerland.

Head and neck cancer is a group of neoplastic diseases affecting the facial, oral, and neck region. It is one of the most common cancers worldwide with an aggressive, invasive evolution. Due to the heterogeneity of the tissues affected, it is particularly challenging to study the molecular mechanisms at the basis of these tumors, and to date we are still lacking accurate targets for prevention and therapy. Read More

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October 2020

Immune Escape Mechanisms and Their Clinical Relevance in Head and Neck Squamous Cell Carcinoma.

Int J Mol Sci 2020 Sep 24;21(19). Epub 2020 Sep 24.

Institute of Pathology, Martin Luther University Halle-Wittenberg, 06112 Halle, Germany.

Immunotherapy has been recently approved for the treatment of relapsed and metastatic human papilloma virus (HPV) positive and negative head and neck squamous cell carcinoma (HNSCC). However, the response of patients is limited and the overall survival remains short with a low rate of long-term survivors. There exists growing evidence that complex and partially redundant immune escape mechanisms play an important role for the low efficacy of immunotherapies in this disease. Read More

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September 2020

Long noncoding RNAs in head and neck squamous cell carcinoma: biological functions and mechanisms.

Mol Biol Rep 2020 Oct 10;47(10):8075-8090. Epub 2020 Sep 10.

Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Nangang District, Harbin, 150081, Heilongjiang, China.

Head and neck squamous cell carcinoma (HNSCC) is the primary malignant tumor of the oral cavity, larynx, nasopharynx, esophagus and tongue. Although several novel therapeutic methods for HNSCC have been developed, the final therapeutic effect on the patient is still not satisfactory. Thus, it is imperative that scientists identify novel distinguishable markers with specific molecular characteristics that can be used in therapeutic and prognostic evaluation. Read More

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October 2020

Small extracellular vesicle-bound vascular endothelial growth factor secreted by carcinoma-associated fibroblasts promotes angiogenesis in a bevacizumab-resistant manner.

Cancer Lett 2020 11 26;492:71-83. Epub 2020 Aug 26.

School of Stomatology, Dalian Medical University, No.9 West Section, South Road of Lvshun, Dalian, 116044, China. Electronic address:

The blood vessel growth inhibitor bevacizumab targets vascular endothelial growth factor (VEGF), a crucial regulator of angiogenesis. Recently, small extracellular vesicles (sEVs) have been demonstrated to be important vehicles in the transport of growth factors to target cells. In this study, we isolated primary carcinoma-associated fibroblasts (CAFs) from four human oral squamous cell carcinoma (OSCC) specimens. Read More

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November 2020

Protein glycosylation in head and neck cancers: From diagnosis to treatment.

Biochim Biophys Acta Rev Cancer 2020 12 25;1874(2):188422. Epub 2020 Aug 25.

Saliva and Liquid Biopsy Translational Laboratory, The School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia; Translational Research Institute, Woolloongabba, QLD, Australia.. Electronic address:

Glycosylation is the most common post-translational modification (PTM) of proteins. Malignant tumour cells frequently undergo an alteration in surface protein glycosylation. This phenomenon is also common in cancers of the head and neck, most of which are squamous cell carcinomas (HNSCC). Read More

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December 2020

High-mobility group box 1 induces bone destruction associated with advanced oral squamous cancer via RAGE and TLR4.

Biochem Biophys Res Commun 2020 10 14;531(3):422-430. Epub 2020 Aug 14.

Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan.

Bone destruction of maxillary and mandibular bone by invasive oral squamous cell cancer (OSCC) raises various problems in the management of patients, resulting in poor outcomes and survival. However, the mechanism behind bone destruction by OSCC remains unclear. High-mobility group box 1 (HMGB1), a highly conserved ubiquitous nuclear non-histone DNA-binding protein, has been demonstrated to be secreted by aggressive cancers and regulate osteoclastogenesis, a central player during bone destruction. Read More

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October 2020

Piperlongumine inhibits head and neck squamous cell carcinoma proliferation by docking to Akt.

Phytother Res 2020 Dec 15;34(12):3345-3358. Epub 2020 Aug 15.

Department of Otorhinolaryngology Head and Neck Surgery, The First Hospital of China Medical University, Shenyang, China.

Piperlongumine (PL) is a biologically active alkaloid isolated from the long pepper roots and widely used as a traditional medicine in Ayurvedic medicine. However, the mechanism of PL's effect on head and neck squamous cell carcinoma (HNSCC) is not well understood. We performed cell experiments to confirm PL's inhibitory effect on HNSCC and employing cisplatin as positive control. Read More

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December 2020

Novel Biomarkers in Sinonasal Cancers: from Bench to Bedside.

Curr Oncol Rep 2020 07 29;22(10):106. Epub 2020 Jul 29.

Royal National Throat, Nose and Ear Hospital/Head and Neck Centre, University College London Hospitals NHS Foundation Trust, London, UK.

Purpose Of Review: Sinonasal cancers are a heterogenous group of rare cancers for which histopathological diagnosis can be very challenging and treatment options are limited for advanced disease in particular. Here, we review the candidacy of novel diagnostic and prognostic biomarkers, and therapeutic targets for sinonasal cancers.

Recent Findings: Molecular multidimensional analyses of sinonasal cancers have been lagging behind other major cancers, but there are numerous publications describing the discovery of novel candidate biomarkers, e. Read More

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Inhibitors of Ceramide- and Sphingosine-Metabolizing Enzymes as Sensitizers in Radiotherapy and Chemotherapy for Head and Neck Squamous Cell Carcinoma.

Cancers (Basel) 2020 Jul 26;12(8). Epub 2020 Jul 26.

Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Suita, Osaka 565-0871, Japan.

In the treatment of advanced head and neck squamous cell carcinoma (HNSCC), including oral SCC, radiotherapy is a commonly performed therapeutic modality. The combined use of radiotherapy with chemotherapy improves therapeutic effects, but it also increases adverse events. Ceramide, a central molecule in sphingolipid metabolism and signaling pathways, mediates antiproliferative responses, and its level increases in response to radiotherapy and chemotherapy. Read More

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