297 results match your criteria Molecular Targets in the Treatment of Head and Neck Squamous Cell Carcinoma


Expression of USP22 and the chromosomal passenger complex is an indicator of malignant progression in oral squamous cell carcinoma.

Oncol Lett 2019 Feb 17;17(2):2040-2046. Epub 2018 Dec 17.

Department of Pathology, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, P.R. China.

Oral cancer is a common cancer of the head and neck. Oral squamous cell carcinoma (OSCC) represents almost 90% of the total cases of head and neck cancer. Ubiquitin-specific protease 22 (USP22) is a deubiquitinating hydrolase, and it is highly expressed in various types of cancer, which also typically have a poor prognosis. Read More

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http://dx.doi.org/10.3892/ol.2018.9837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341666PMC
February 2019

Integrated analyses utilizing metabolomics and transcriptomics reveal perturbation of the polyamine pathway in oral cavity squamous cell carcinoma.

Anal Chim Acta 2019 Mar 2;1050:113-122. Epub 2018 Nov 2.

Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Otolaryngology - Head & Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Oral cavity squamous cell carcinoma (OSCC), the most common malignancy of the oral cavity, is associated with poor prognosis and high mortality worldwide. Moreover, knowledge of the metabolic alterations that occur in OSCC is still limited. In the present study, we used a quantitative metabolomic approach with chemical isotope labeling (CIL) to analyze alterations in the metabolite levels in paired cancerous (T) and adjacent noncancerous (AN) tissues from 31 OSCC patients. Read More

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http://dx.doi.org/10.1016/j.aca.2018.10.070DOI Listing
March 2019
1 Read

Histoepigenetic analysis of HPV- and tobacco-associated head and neck cancer identifies both subtype-specific and common therapeutic targets despite divergent microenvironments.

Oncogene 2019 Jan 17. Epub 2019 Jan 17.

Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX, USA.

Although head and neck squamous cell carcinoma (HNSCC) has in the past been largely associated with tobacco use, human papillomavirus (HPV+) oropharynx cancer has in recent years emerged as the fastest growing type of HNSCC. Patients with HPV+ HNSCC have a better prognosis; however, the 5-year survival for both HPV+ and HPV- subtypes with recurrent or metastatic disease is poor. To gain insights into the tumor microenvironments of both HNSCC subtypes and identify potential therapeutic targets, we performed epigenomic deconvolution on 580 HNSCC samples from the TCGA dataset. Read More

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http://dx.doi.org/10.1038/s41388-018-0659-4DOI Listing
January 2019

The effect of 2D and 3D cell cultures on treatment response, EMT profile and stem cell features in head and neck cancer.

Cancer Cell Int 2019 14;19:16. Epub 2019 Jan 14.

1Division of Cell Biology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Background: Head and Neck Squamous Cell Carcinoma (HNSCC) tumors are often resistant to therapies. Therefore searching for predictive markers and new targets for treatment in clinically relevant in vitro tumor models is essential. Five HNSCC-derived cell lines were used to assess the effect of 3D culturing compared to 2D monolayers in terms of cell proliferation, response to anti-cancer therapy as well as expression of EMT and CSC genes. Read More

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http://dx.doi.org/10.1186/s12935-019-0733-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332598PMC
January 2019
1 Read

Prognostic signature associated with radioresistance in head and neck cancer via transcriptomic and bioinformatic analyses.

BMC Cancer 2019 Jan 14;19(1):64. Epub 2019 Jan 14.

Department of Radiation Oncology, Chang Gung Memorial Hospital-Linkou, Taoyuan, Taiwan.

Background: Radiotherapy is an indispensable treatment modality in head and neck cancer (HNC), while radioresistance is the major cause of treatment failure. The aim of this study is to identify a prognostic molecular signature associated with radio-resistance in HNC for further clinical applications.

Methods: Affymetrix cDNA microarrays were used to globally survey different transcriptomes between HNC cell lines and isogenic radioresistant sublines. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-5243-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332600PMC
January 2019
6 Reads
3.362 Impact Factor

Clinical and molecular characteristics associated with the efficacy of PD-1/PD-L1 inhibitors for solid tumors: a meta-analysis.

Onco Targets Ther 2018 30;11:7529-7542. Epub 2018 Oct 30.

Department of Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, People's Republic of China,

We conducted a meta-analysis to estimate the impact of different clinical and molecular characteristics on the efficacy of programmed cell death 1 (PD-1) or programmed cell death ligand 1 (PD-L1) inhibitors. PubMed and Web of Science were searched for related trials. Eleven eligible studies, comprising 5,663 patients, were included in this meta-analysis. Read More

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http://dx.doi.org/10.2147/OTT.S167865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214579PMC
October 2018
13 Reads

Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma.

Head Neck 2018 Dec 20;40(12):2685-2694. Epub 2018 Nov 20.

Department of Oral and Cranio-Maxillofacial Surgery, University Hospital Heidelberg, Heidelberg, Germany.

Background: Cortactin (CTTN) is located on chromosome 11q13 and is associated with invasiveness in various cancer entities. CTTN protein expression could be a prognosticator of oral squamous cell carcinoma (OSCC) in terms of recurrence and survival.

Methods: CTTN-dependent invasion was performed using migration assay in human papillomavirus-negative head and neck squamous cell carcinoma (HNSCC) cells. Read More

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http://dx.doi.org/10.1002/hed.25515DOI Listing
December 2018
4 Reads

lncRNA Expression after Irradiation and Chemoexposure of HNSCC Cell Lines.

Noncoding RNA 2018 Nov 14;4(4). Epub 2018 Nov 14.

Laboratory of Cancer Genetics, Greater Poland Cancer Centre, 61-866 Poznan, Poland.

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cause of cancer mortality in the world. To improve the quality of diagnostics and patients' treatment, new and effective biomarkers are needed. Recent studies have shown that the expression level of different types of long non-coding RNAs (lncRNAs) is dysregulated in HNSCC and correlates with many biological processes. Read More

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http://www.mdpi.com/2311-553X/4/4/33
Publisher Site
http://dx.doi.org/10.3390/ncrna4040033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315432PMC
November 2018
7 Reads

Vimentin and Non-Muscle Myosin IIA are Members of the Neural Precursor Cell Expressed Developmentally Down-Regulated 9 (NEDD9) Interactome in Head and Neck Squamous Cell Carcinoma Cells.

Transl Oncol 2019 Jan 26;12(1):49-61. Epub 2018 Sep 26.

Department of Cell and Molecular Pharmacology & Experimental Therapeutics, Medical University of South Carolina, 173 Ashley Avenue MSC 509, Charleston, SC 29425-5050; Hollings Cancer Center, Medical University of South Carolina, 173 Ashley Avenue MSC 550, Charleston, SC 29425-5050. Electronic address:

Here we demonstrate an interaction between neural precursor cell expressed, developmentally-downregulated 9 (NEDD9) and the cytoskeletal proteins vimentin and non-muscle myosin IIA (NMIIA), based on co-immunoprecipitation and mass spectrometric sequence identification. Vimentin was constitutively phosphorylated at Ser56 but vimentin associated with NEDD9-was not phosphorylated at Ser56. In contrast, NMIIA bound to NEDD9 was phosphorylated on S1943 consistent with its function in invasion and secretion. Read More

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http://dx.doi.org/10.1016/j.tranon.2018.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160858PMC
January 2019

Investigation of novel chemotherapeutics for feline oral squamous cell carcinoma.

Oncotarget 2018 Sep 4;9(69):33098-33109. Epub 2018 Sep 4.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.

Feline oral squamous cell carcinomas (FOSCC) are highly aggressive neoplasms with short survival times despite multimodal treatment. FOSCC are similar to squamous cell carcinomas of the head and neck (SCCHN) in humans, which also present therapeutic challenges. The current study was undertaken to identify novel chemotherapeutics using FOSCC cell lines. Read More

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http://dx.doi.org/10.18632/oncotarget.26006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145701PMC
September 2018

Differentially expressed proteins in positive versus negative HNSCC lymph nodes.

BMC Med Genomics 2018 Aug 29;11(1):73. Epub 2018 Aug 29.

Departamento de Biologia Molecular, Faculdade de Medicina (FAMERP), Av. Brigadeiro Faria Lima, 5416, Vila São Pedro, São José do Rio Preto, SP, CEP 15090-000, Brazil.

Background: Lymph node metastasis is one of the most important prognostic factors in head and neck squamous cell carcinomas (HNSCCs) and critical for delineating their treatment. However, clinical and histological criteria for the diagnosis of nodal status remain limited. In the present study, we aimed to characterize the proteomic profile of lymph node metastasis from HNSCC patients. Read More

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http://dx.doi.org/10.1186/s12920-018-0382-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114741PMC
August 2018
15 Reads

Transcobalamin I: a novel prognostic biomarker of neoadjuvant chemotherapy in locally advanced hypopharyngeal squamous cell cancers.

Onco Targets Ther 2018 24;11:4253-4261. Epub 2018 Jul 24.

Department of Pathology, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China,

Background: Hypopharyngeal squamous cell carcinoma (HPSCC) is an aggressive head and neck squamous cell carcinoma with poor prognosis. Neoadjuvant chemotherapy (NACT) followed by concurrent chemoradiotherapy could provide better efficacy in HPSCC treatment. Identification of predictive biomarkers is critically needed to improve selection of patients who derive the most benefit from NACT. Read More

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http://dx.doi.org/10.2147/OTT.S166514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065467PMC
July 2018
5 Reads

ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation.

J Clin Invest 2018 Aug 13;128(9):3926-3940. Epub 2018 Aug 13.

Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

DNA-damaging chemotherapy and radiation therapy are integrated into the treatment paradigm of the majority of cancer patients. Recently, immunotherapy that targets the immunosuppressive interaction between programmed death 1 (PD-1) and its ligand PD-L1 has been approved for malignancies including non-small cell lung cancer, melanoma, and head and neck squamous cell carcinoma. ATR is a DNA damage-signaling kinase activated at damaged replication forks, and ATR kinase inhibitors potentiate the cytotoxicity of DNA-damaging chemotherapies. Read More

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http://dx.doi.org/10.1172/JCI96519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118586PMC
August 2018
8 Reads

Whole-Transcriptome Analysis of CD133+CD144+ Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma Cells.

Cell Physiol Biochem 2018 27;47(4):1696-1710. Epub 2018 Jun 27.

Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Taiyuan, China.

Background/aims: CD133+CD44+ cancer stem cells previously isolated from laryngeal squamous cell carcinoma (LSCC) cell lines showed strong malignancy and tumorigenicity. However, the molecular mechanism underlying the enhanced malignancy remained unclear.

Methods: Cell proliferation assay, spheroid-formation experiment, RNA sequencing (RNA-seq), miRNA-seq, bioinformatic analysis, quantitative real-time PCR, migration assay, invasion assay, and luciferase reporter assay were used to identify differentially expressed mRNAs, lncRNAs, circRNAs and miRNAs, construct transcription regulatory network, and investigate functional roles and mechanism of circRNA in CD133+CD44+ laryngeal cancer stem cells. Read More

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http://dx.doi.org/10.1159/000490992DOI Listing
August 2018
11 Reads

Protein-Protein Interaction Network Analysis of Salivary Proteomic Data in Oral Cancer Cases

Asian Pac J Cancer Prev 2018 Jun 25;19(6):1639-1645. Epub 2018 Jun 25.

Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email:

Background: Oral cancer is a frequently encountered neoplasm of the head and neck region, being the eight most common type of human malignancy worldwide. Despite improvement in its control, morbidity and mortality rates have improved little in the past decades. Therefore, prevention and/or early detection are a high priority. Read More

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http://journal.waocp.org/article_62752.html
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http://dx.doi.org/10.22034/APJCP.2018.19.6.1639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103602PMC
June 2018
3 Reads

Drug Targeting and Biomarkers in Head and Neck Cancers: Insights from Systems Biology Analyses.

OMICS 2018 06;22(6):422-436

5 Laboratory of Bioinformatics, Department of Statistics, University of Rajshahi , Rajshahi, Bangladesh .

The head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers in the world, but robust biomarkers and diagnostics are still not available. This study provides in-depth insights from systems biology analyses to identify molecular biomarker signatures to inform systematic drug targeting in HNSCC. Gene expression profiles from tumors and normal tissues of 22 patients with histological confirmation of nonmetastatic HNSCC were subjected to integrative analyses with genome-scale biomolecular networks (i. Read More

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http://dx.doi.org/10.1089/omi.2018.0048DOI Listing
June 2018
6 Reads

Precision Medicine in Head and Neck Cancer: Myth or Reality?

Clin Med Insights Oncol 2018 4;12:1179554918779581. Epub 2018 Jun 4.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON, Canada.

Standard treatment in head and neck squamous cell carcinoma (HNSCC) is limited currently with decisions being made primarily based on tumor location, histology, and stage. The role of the human papillomavirus in risk stratification is actively under clinical trial evaluations. The molecular complexity and intratumoral heterogeneity of the disease are not actively integrated into management decisions of HNSCC, despite a growing body of knowledge in these areas. Read More

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http://dx.doi.org/10.1177/1179554918779581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989049PMC
June 2018
3 Reads

Epigenetic inactivation of galanin receptors in salivary duct carcinoma of the parotid gland: Potential utility as biomarkers for prognosis.

Oncol Lett 2018 Jun 18;15(6):9043-9050. Epub 2018 Apr 18.

Department of Otolaryngology/Head and Neck Surgery, Jichi Medical University, Shimotsuke, Tochigi 329-0498, Japan.

Salivary duct carcinoma (SDC) constitutes one of the most aggressive cancers in the salivary gland and is associated with a poor prognosis; however, no established systemic therapy options are available. SDC exhibits biological similarity to prostate and breast cancers, therefore anti-hormone therapy and molecular target therapies are available, however with limited beneficial effects. Galanin and galanin receptors (GALRs) are well established as molecular biomarkers to predict the survival rate and risk of recurrence of head and neck squamous cell carcinoma. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.8525
Publisher Site
http://dx.doi.org/10.3892/ol.2018.8525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958682PMC
June 2018
5 Reads

MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma.

Sci Rep 2018 May 14;8(1):7531. Epub 2018 May 14.

Department of Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, London, UK.

Sebaceous gland carcinoma (SGC) is a rare, but life-threatening condition with a predilection for the periocular region. Eyelid SGC can be broadly categorised into two subtypes, namely either nodular or pagetoid with the latter being more aggressive and requiring radical excision to save life. We have identified key altered microRNAs (miRNA) involved in SGC shared by both subtypes, hsa-miR-34a-5p and hsa-miR-16-5p. Read More

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http://dx.doi.org/10.1038/s41598-018-25900-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951834PMC
May 2018
10 Reads

Investigating the Feasibility of Targeted Next-Generation Sequencing to Guide the Treatment of Head and Neck Squamous Cell Carcinoma.

Cancer Res Treat 2019 Jan 9;51(1):300-312. Epub 2018 May 9.

Divison of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Head and neck squamous cell carcinoma (HNSCC) is a deadly disease in which precision medicine needs to be incorporated. We aimed to implement next-generation sequencing (NGS) in determining actionable targets to guide appropriate molecular targeted therapy in HNSCC patients.

Materials And Methods: Ninety-three tumors and matched blood samples underwent targeted sequencing of 244 genes using the Illumina HiSeq 2500 platform with an average depth of coverage of greater than 1,000×. Read More

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http://dx.doi.org/10.4143/crt.2018.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333965PMC
January 2019
19 Reads

Application of molecular targeted therapies in the treatment of head and neck squamous cell carcinoma.

Oncol Lett 2018 May 20;15(5):7497-7505. Epub 2018 Mar 20.

Department of Oncology, Medical University of Lublin, 20-90 Lublin, Poland.

Despite the development of standard therapies, including surgery, radiotherapy and chemotherapy, survival rates for head and neck squamous cell carcinoma (HNSCC) have not changed significantly over the past three decades. Complete recovery is achieved in <50% of patients. The treatment of advanced HNSCC frequently requires multimodality therapy and involves significant toxicity. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.8300
Publisher Site
http://dx.doi.org/10.3892/ol.2018.8300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920345PMC
May 2018
7 Reads

Whole exome sequencing identifies mTOR and KEAP1 as potential targets for radiosensitization of HNSCC cells refractory to EGFR and β1 integrin inhibition.

Oncotarget 2018 Apr 6;9(26):18099-18114. Epub 2018 Apr 6.

OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany.

Intrinsic and acquired resistances are major obstacles in cancer therapy. Genetic characterization is commonly used to identify predictive or prognostic biomarker signatures and potential cancer targets in samples from therapy-naïve patients. By far less common are such investigations to identify specific, predictive and/or prognostic gene signatures in patients or cancer cells refractory to a specific molecular-targeted intervention. Read More

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http://dx.doi.org/10.18632/oncotarget.24266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915060PMC
April 2018
2 Reads

Precision Therapy of Head and Neck Squamous Cell Carcinoma.

J Dent Res 2018 Jun 12;97(6):614-621. Epub 2018 Apr 12.

1 Department of Periodontics and Oral Medicine, Division of Oral Medicine, Pathology, and Radiology, University of Michigan School of Dentistry, Ann Arbor, MI, USA.

Precision medicine is an approach to disease prevention and treatment that takes into account genetic variability and environmental and lifestyle influences that are unique to each patient. It facilitates stratification of patient populations that vary in their susceptibility to disease and response to therapy. Shared databases and the implementation of new technology systems designed to advance the integration of this information will enable health care providers to more accurately predict and customize prevention and treatment strategies for patients. Read More

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http://dx.doi.org/10.1177/0022034518769645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960884PMC

Let-7c inhibits migration and epithelial-mesenchymal transition in head and neck squamous cell carcinoma by targeting and .

Oncotarget 2018 Feb 2;9(10):8927-8940. Epub 2018 Jan 2.

Department of Environmental and Molecular Medicine, Graduate School of Medicine, Mie University, Tsu, Mie 514-8507, Japan.

To elucidate the molecular mechanisms underlying the progression of head and neck squamous cell carcinoma (HNSCC), we investigated the function of let-7c as a tumor suppressor. Let-7c expression was significantly down-regulated in HNSCC tumor tissues and cell lines. and studies revealed that let-7c negatively regulated HNSCC proliferation, migration and epithelial-mesenchymal transition (EMT). Read More

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http://dx.doi.org/10.18632/oncotarget.23826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823619PMC
February 2018
4 Reads

CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma.

Oral Oncol 2018 Mar 20;78:145-150. Epub 2018 Feb 20.

Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA. Electronic address:

Objectives: In accordance with the Precision Medicine Initiative, new treatment strategies for head and neck squamous cell carcinoma (HNSCC) are needed to yield better therapeutic outcomes. The purpose of this study was to establish and validate chimeric antigen receptor (CAR)-T cells targets in HNSCC.

Methods: Putative CAR-T antigens were identified in The Cancer Genome Atlas database. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836804PMC
March 2018
15 Reads

Identification of gene expression models for laryngeal squamous cell carcinoma using co-expression network analysis.

Medicine (Baltimore) 2018 Feb;97(7):e9738

Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Union Medical Center.

One of the most common head and neck cancers is laryngeal squamous cell carcinoma (LSCC). LSCC exhibits high mortality rates and has a poor prognosis. The molecular mechanisms leading to the development and progression of LSCC are not entirely clear despite genetic and therapeutic advances and increased survival rates. Read More

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http://dx.doi.org/10.1097/MD.0000000000009738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839854PMC
February 2018
5 Reads

Analysis of Invasive Activity of CAF Spheroids into Three Dimensional (3D) Collagen Matrices.

Methods Mol Biol 2018 ;1731:145-154

Servicio de Otorrinolaringología, Hospital Universitario Central de Asturias and Instituto Universitario de Oncología del Principado de Asturias, (IUOPA), Oviedo, Spain.

Tumor growth and progression is the result of a complex process controlled not only by malignant cancer cells but also by the surrounding tumor microenvironment (TME). Cancer associated fibroblasts (CAFs), the most abundant cellular component of TME, play an active role in tumor invasion and metastasis by promoting cancer cell invasion through cell-cell interactions and secretion of pro-invasive factors such as extracellular matrix (ECM)-degrading proteases. Due to their tumor-promoting activities, there is an emerging interest in investigating CAFs biology and its potential as drug targets for cancer therapies. Read More

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http://dx.doi.org/10.1007/978-1-4939-7595-2_14DOI Listing
January 2019
6 Reads

Expression of miR-373 and its predicted target genes E-cadherin and CD44 in patients with laryngeal squamous cell carcinoma.

Cell Mol Biol (Noisy-le-grand) 2017 Dec 30;63(12):29-33. Epub 2017 Dec 30.

Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.

Laryngeal squamous cell carcinoma (LSCC) is a genomically complex disease that is difficult to target, and efforts have been made to identify new treatment strategies and   molecular markers that might stratify patients and individualize options for treatment. miR-373 has diametrically opposed roles in different stages and types of cancers. miR-373 has been suggested to quantitatively control E-cadherin and CD44 expression. Read More

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http://dx.doi.org/10.14715/cmb/2017.63.12.8DOI Listing
December 2017
7 Reads

Competing endogenous RNA network analysis of CD274, IL‑10 and FOXP3 co‑expression in laryngeal squamous cell carcinoma.

Mol Med Rep 2018 Mar 19;17(3):3859-3869. Epub 2017 Dec 19.

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.

Laryngeal squamous cell carcinoma (LSCC) is one of the most common types of head and neck malignant tumor; however, there is a lack of effective molecular targets for therapy. The present study detected the expression of three immunity‑associated molecules [forkhead box (FOX)3, interleukin (IL)‑10 and cluster of differentiation (CD)274] in 133 LSCC samples using immunohistochemistry (IHC); subsequently, the association between their expression and the clinical characteristics of LSCC were analyzed. Spearman's rank correlation method, Kaplan‑Meier and Cox regression model were used to analyze the correlations of the three proteins and their clinical significance. Read More

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http://dx.doi.org/10.3892/mmr.2017.8307DOI Listing
March 2018
8 Reads

miRNAs: Important Targets for Oral Cancer Pain Research.

Biomed Res Int 2017 30;2017:4043516. Epub 2017 Oct 30.

Instituto de Ciências Biomédicas (ICB), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

Pain is a symptom shared by an incredible number of diseases. It is also one of the primary conditions that prompt individuals to seek medical treatment. Head and neck squamous cell carcinoma (HNSCC) corresponds to a heterogeneous disease that may arise from many distinct structures of a large, highly complex, and intricate region. Read More

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http://dx.doi.org/10.1155/2017/4043516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682905PMC
July 2018
9 Reads

Immuno-PET imaging based radioimmunotherapy in head and neck squamous cell carcinoma model.

Oncotarget 2017 Nov 8;8(54):92090-92105. Epub 2017 Sep 8.

Division of Radiological and Clinical Research, Korea Cancer Center Hospital (KCCH), Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Republic of Korea.

The epidermal growth factor receptor (EGFR) is one of the most comprehensively studied molecular targets in head and neck squamous cell carcinoma (HNSCC). However, inherent and acquired resistance are serious problems and are responsible for limited clinical efficacy and tumor recurrence. In this study, we evaluated the feasibility of immuno-positron emission tomography (PET) imaging and radioimmunotherapy (RIT) with Cu-/Lu-PCTA-cetuximab in cetuximab-resistant SNU-1066 HNSCC xenografted model. Read More

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http://dx.doi.org/10.18632/oncotarget.20760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696166PMC
November 2017
39 Reads

A three gene immunohistochemical panel serves as an adjunct to clinical staging of patients with head and neck cancer.

Oncotarget 2017 Oct 19;8(45):79556-79566. Epub 2017 Jun 19.

Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, S169857, Singapore.

Background: Current management of head and neck squamous cell carcinoma (HNSCC) depends on tumor staging. Despite refinements in clinical staging algorithms, outcomes remain unchanged for the last two decades. In this study, we set out to identify a small, clinically applicable molecular panel to aid prognostication of patients with HNSCC. Read More

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http://dx.doi.org/10.18632/oncotarget.18568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668068PMC
October 2017
31 Reads

CD44v6-Targeted Imaging of Head and Neck Squamous Cell Carcinoma: Antibody-Based Approaches.

Contrast Media Mol Imaging 2017 20;2017:2709547. Epub 2017 Jun 20.

Division of Protein Technology, School of Biotechnology, Royal Institute of Technology, Stockholm, Sweden.

Head and neck squamous cell carcinoma (HNSCC) is a common and severe cancer with low survival rate in advanced stages. Noninvasive imaging of prognostic and therapeutic biomarkers could provide valuable information for planning and monitoring of the different therapy options. Thus, there is a major interest in development of new tracers towards cancer-specific molecular targets to improve diagnostic imaging and treatment. Read More

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http://dx.doi.org/10.1155/2017/2709547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612744PMC

Genomics and advances towards precision medicine for head and neck squamous cell carcinoma.

Laryngoscope Investig Otolaryngol 2017 10 22;2(5):310-319. Epub 2017 Aug 22.

Head and Neck Surgery Branch National Institute on Deafness and Other Communication Disorders Bethesda Maryland U.S.A.

Objective: To provide a review of emerging knowledge from genomics and related basic science, preclinical, and clinical precision medicine studies in head and neck squamous cell carcinoma (HNSCC).

Data Sources: The Cancer Genome Atlas Network (TCGA) publications, PubMed-based literature review, and ClinicalTrials.gov. Read More

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http://dx.doi.org/10.1002/lio2.86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655563PMC
October 2017
1 Read

Multilayered Omics-Based Analysis of a Head and Neck Cancer Model of Cisplatin Resistance Reveals Intratumoral Heterogeneity and Treatment-Induced Clonal Selection.

Clin Cancer Res 2018 Jan 23;24(1):158-168. Epub 2017 Oct 23.

Charité, Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Radiooncology and Radiotherapy, Berlin, Germany.

Platinum-based drugs, in particular cisplatin (cis-diamminedichloridoplatinum(II), CDDP), are used for treatment of squamous cell carcinoma of the head and neck (SCCHN). Despite initial responses, CDDP treatment often results in chemoresistance, leading to therapeutic failure. The role of primary resistance at subclonal level and treatment-induced clonal selection in the development of CDDP resistance remains unknown. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-2410DOI Listing
January 2018
8 Reads

Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma.

Mod Pathol 2018 02 6;31(2):275-287. Epub 2017 Oct 6.

Central Clinical School, The University of Sydney, Sydney, Australia.

Cutaneous squamous cell carcinoma is the second most prevalent malignancy, most frequently occurring in the head and neck (head and neck cutaneous squamous cell carcinoma). Treatment of locally advanced or metastatic disease is associated with functional morbidity and disfigurement. Underlying genetic mechanisms are poorly understood. Read More

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http://www.nature.com/doifinder/10.1038/modpathol.2017.128
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http://dx.doi.org/10.1038/modpathol.2017.128DOI Listing
February 2018
18 Reads

Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells.

Sci Rep 2017 Sep 29;7(1):12423. Epub 2017 Sep 29.

Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Radiation Biology, Neuherberg, Germany.

Radiation is a highly efficient therapy in squamous head and neck carcinoma (HNSCC) treatment. However, local recurrence and metastasis are common complications. Recent evidence shows that cancer-cell-derived exosomes modify tumour cell movement and metastasis. Read More

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http://dx.doi.org/10.1038/s41598-017-12403-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622080PMC
September 2017
28 Reads

SKLB188 inhibits the growth of head and neck squamous cell carcinoma by suppressing EGFR signalling.

Br J Cancer 2017 Oct 5;117(8):1154-1163. Epub 2017 Sep 5.

Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USA.

Background: Overexpression of epidermal growth factor receptor (EGFR) occurs in approximately 90% of head and neck squamous cell carcinoma (HNSCC), and is correlated with poor prognosis. Thus, targeting EGFR is a promising strategy for treatment of HNSCC. Several small molecule EGFR inhibitors have been tested in clinical trials for treatment of HNSCC, but none of them are more effective than the current chemotherapeutic drugs. Read More

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http://www.nature.com/doifinder/10.1038/bjc.2017.298
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http://dx.doi.org/10.1038/bjc.2017.298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674107PMC
October 2017
37 Reads
1 Citation
4.840 Impact Factor

Urokinase-type plasminogen activator receptor (uPAR), tissue factor (TF) and epidermal growth factor receptor (EGFR): tumor expression patterns and prognostic value in oral cancer.

BMC Cancer 2017 Aug 25;17(1):572. Epub 2017 Aug 25.

Department of Otolaryngology, Head & Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: Tumor-specific biomarkers are a prerequisite for the development of targeted imaging and therapy in oral squamous cell carcinoma (OSCC). urokinase-type Plasminogen Activator Receptor (uPAR), Tissue Factor (TF) and Epidermal Growth Factor Receptor (EGFR) are three biomarkers that exhibit enhanced expression in many types of cancers, and have been investigated as potential biomarkers for targeted strategies and prognostication. The aim of the study was to investigate the expression patterns of uPAR, TF and EGFR and their potential prognostic value in OSCC. Read More

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http://dx.doi.org/10.1186/s12885-017-3563-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574145PMC
August 2017
12 Reads

Activation of Matrix Hyaluronan-Mediated CD44 Signaling, Epigenetic Regulation and Chemoresistance in Head and Neck Cancer Stem Cells.

Int J Mol Sci 2017 Aug 24;18(9). Epub 2017 Aug 24.

San Francisco Veterans Affairs Medical Center and Department of Medicine, University of California at San Francisco & Endocrine Unit (111N2), 4150 Clement Street, San Francisco, CA 94121, USA.

Head and neck squamous cell carcinoma (HNSCC) is a solid tumor composed by a genotypically and phenotypically heterogeneous population of neoplastic cells types. High recurrence rate and regional metastases lead to major morbidity and mortality. Recently, many studies have focused on cellular and molecular mechanisms of tumor progression that can help to predict prognosis and to choose the best therapeutic approach for HNSCC patients. Read More

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http://dx.doi.org/10.3390/ijms18091849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618498PMC
August 2017
4 Reads

AP1G1 is involved in cetuximab-mediated downregulation of ASCT2-EGFR complex and sensitization of human head and neck squamous cell carcinoma cells to ROS-induced apoptosis.

Cancer Lett 2017 11 18;408:33-42. Epub 2017 Aug 18.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

In this study, we expanded our recent work showing that ASCT2, a Na-dependent neutral amino acid transporter that plays a major role in glutamine uptake in cancer cells, is physically associated with EGFR in human head and neck squamous cell carcinoma cells and in several other types of cancer cells. We found in our current study that ASCT2 can be downregulated by cetuximab, an approved anti-EGFR therapeutic antibody, via cetuximab-induced EGFR endocytosis independently of cetuximab-mediated inhibition of EGFR tyrosine kinase. We further found that ASCT2-EGFR association involves the adaptor-related protein complex 1 gamma 1 subunit (AP1G1), a subunit of clathrin-associated adaptor protein complex 1, which plays a role in membrane protein sorting in endosomes after receptor-mediated endocytosis. Read More

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http://dx.doi.org/10.1016/j.canlet.2017.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628150PMC
November 2017
31 Reads

Angiotensin-Converting Enzymes (ACE and ACE2) as Potential Targets for Malignant Epithelial Neoplasia: Review and Bioinformatics Analyses Focused in Oral Squamous Cell Carcinoma.

Protein Pept Lett 2017 Nov;24(9):784-792

Department of Dentistry, Universidade Estadual de Montes Claros, Minas Gerais, Brazil.

Introduction: The Renin-Angiotensin System (RAS) has emerged as being related to vascular disease. Recently the RAS has been associated with obesity, diabetes, and even cancer.

Objective: This review and Bioinformatics analyses focuses on the investigation of Angiotensinconverting enzymes (ACE and ACE2) as therapeutical targets for Malignant Epithelial Neoplasia, specifically for Oral Squamous Cell Carcinoma (OSCC). Read More

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http://dx.doi.org/10.2174/0929866524666170815161621DOI Listing
November 2017
1 Read

Impact of combined treatment with nimesulide and cisplatin on oral carcinoma cells.

Onco Targets Ther 2017 19;10:3607-3616. Epub 2017 Jul 19.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria.

Background: Despite significant advances in diagnosis and therapy, the rate of survival of patients with oral cancers still remains poor as an appropriate treatment has not been found yet, due to side effects of chemo/radiotherapy.

Aim: This study aimed to identify molecular mechanisms of cell death of oral cancer cells caused by treatment with a nonselective Cox-2 inhibitor in combination with a low-dose chemotherapeutic drug.

Methods: Squamous cell carcinoma (SCC) cells SCC9 and SCC25 were subjected to mono- and combination therapy with nimesulide and cisplatin. Read More

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http://dx.doi.org/10.2147/OTT.S131106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530852PMC
July 2017
21 Reads

Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer.

J Am Soc Mass Spectrom 2017 10 27;28(10):2078-2089. Epub 2017 Jul 27.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.

With recent advances in understanding the genomic underpinnings and oncogenic drivers of pathogenesis in different subtypes, it is increasingly clear that proper pretreatment diagnostics are essential for the choice of appropriate treatment options for non-small cell lung cancer (NSCLC). Tumor tissue preservation in optimal cutting temperature (OCT) compound is commonly used in the surgical suite. However, proteins recovered from OCT-embedded specimens pose a challenge for LC-MS/MS experiments, due to the large amounts of polymers present in OCT. Read More

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http://dx.doi.org/10.1007/s13361-017-1706-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693617PMC
October 2017
17 Reads

Microarray gene expression analysis of chemosensitivity for docetaxel, cisplatin and 5-fluorouracil (TPF) combined chemotherapeutic regimen in hypopharyngeal squamous cell carcinoma.

Chin J Cancer Res 2017 Jun;29(3):204-212

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

Objective: To screen out a set of candidate genes which could help to determine whether patients with hypopharyngeal squamous cell carcinoma (HSCC) could benefit from docetaxel, cisplatin and 5-fluorouracil (TPF) induction chemotherapy.

Methods: Gene-expression profiles in 12 TPF-sensitive patients were compared to 9 resistant controls by microarray analysis. Subsequently, expression levels of potential biomarkers in chemosensitive cell line FaDu after TPF treatment were observed by quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.21147/j.issn.1000-9604.2017.03.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497207PMC
June 2017
11 Reads

Different levels of let-7d expression modulate response of FaDu cells to irradiation and chemotherapeutics.

PLoS One 2017 30;12(6):e0180265. Epub 2017 Jun 30.

Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.

The implication of the let-7 family in cancer development is multifaceted. The family acts as tumor suppressor miRNA although overexpression of let-7 has also been described in many types of cancer, including head and neck squamous cell carcinoma (HNSCC). The aim of this study includes whether different expression levels of let-7d has an influence on chemo- and radiosensitivity. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180265PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493379PMC
October 2017
15 Reads

Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer.

Nat Immunol 2017 Aug 19;18(8):940-950. Epub 2017 Jun 19.

Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK.

Therapies that boost the anti-tumor responses of cytotoxic T lymphocytes (CTLs) have shown promise; however, clinical responses to the immunotherapeutic agents currently available vary considerably, and the molecular basis of this is unclear. We performed transcriptomic profiling of tumor-infiltrating CTLs from treatment-naive patients with lung cancer to define the molecular features associated with the robustness of anti-tumor immune responses. We observed considerable heterogeneity in the expression of molecules associated with activation of the T cell antigen receptor (TCR) and of immunological-checkpoint molecules such as 4-1BB, PD-1 and TIM-3. Read More

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http://dx.doi.org/10.1038/ni.3775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036910PMC
August 2017
57 Reads

Inhibitory Effect of 1,8-Cineol on β-Catenin Regulation, WNT11 Expression, and Cellular Progression in HNSCC.

Front Oncol 2017 22;7:92. Epub 2017 May 22.

Clinic for Otorhinolaryngology, Head and Neck Surgery, University Clinic Schleswig Holstein, Lübeck, Germany.

Objectives: Head and neck squamous cell carcinoma (HNSCC) is one of the most common tumors worldwide. The high mortality rates have not changed during the last three decades, and thus there is an enormous need for innovative therapy approaches. Several recent studies suggest an important role of the Wnt/β-catenin signaling pathway in the tumorigenesis of HNSCC. Read More

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http://journal.frontiersin.org/article/10.3389/fonc.2017.000
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http://dx.doi.org/10.3389/fonc.2017.00092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438970PMC
May 2017
21 Reads

analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia.

Cell Death Discov 2017 22;3:17022. Epub 2017 May 22.

Department of Otolaryngology-Head and Neck Cancer Research, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.

A subset of patients with oral squamous cell carcinoma (OSCC), the most common subtype of head and neck squamous cell carcinoma (HNSCC), harbor dysplastic lesions (often visually identified as leukoplakia) prior to cancer diagnosis. Although evidence suggest that leukoplakia represents an initial step in the progression to cancer, signaling networks driving this progression are poorly understood. Here, we applied Pathway Activation Network Decomposition Analysis (iPANDA), a new bioinformatics software suite for qualitative analysis of intracellular signaling pathway activation using transcriptomic data, to assess a network of molecular signaling in OSCC and pre-neoplastic oral lesions. Read More

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http://dx.doi.org/10.1038/cddiscovery.2017.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439156PMC
May 2017
42 Reads
3 Citations

Impact of Small Molecules on β-Catenin and E-Cadherin Expression in HPV16-positive and -negative Squamous Cell Carcinomas.

Anticancer Res 2017 06;37(6):2845-2852

Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.

Background: The validation of potential molecular targets in head and neck squamous cell carcinoma (SCC) is mandatory. β-Catenin and E-cadherin are crucial for cancer progression through epithelial-mesenchymal transition. We analyzed the effect of the tyrosine kinase inhibitors nilotinib, dasatinib, erlotinib and gefitinib on β-catenin and E-cadherin expression in SCC with respect to human papillomavirus (HPV) status. Read More

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http://dx.doi.org/10.21873/anticanres.11636DOI Listing
June 2017
30 Reads