1,083 results match your criteria Molecular Pain [Journal]


Calcitonin gene-related peptide potentiated the excitatory transmission and network propagation in the anterior cingulate cortex of adult mice.

Mol Pain 2019 Feb 5:1744806919832718. Epub 2019 Feb 5.

University of Toronto.

The neuropeptide of calcitonin gene-related peptide (CGRP) plays critical roles in chronic pain, especially in migraine. Immunohistochemistry and in situ hybridization studies have shown that CGRP and its receptors are expressed in cortical areas including pain perception related prefrontal anterior cingulate cortex (ACC). However, less information is available for the functional roles of CGRP in cortical regions such as the ACC. Read More

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http://dx.doi.org/10.1177/1744806919832718DOI Listing
February 2019

Neuroinflammation and central PI3K/Akt/mTOR signal pathway contribute to bone cancer pain.

Mol Pain 2019 Feb 5:1744806919830240. Epub 2019 Feb 5.

First Hospital of Jilin University.

Pain is one of the most common and distressing symptoms suffered by patients with progression of cancer; however, the mechanisms responsible for hyperalgesia are not well understood. Since the midbrain periaqueductal gray (PAG) is an important component of the descending inhibitory pathway controlling on central pain transmission, in this study we examined the role for pro-inflammatory cytokines (PICs) of the PAG in regulating mechanical and thermal hyperalgesia evoked by bone cancer via PI3K-mTOR signals. Breast sarcocarcinoma Walker 256 cells were implanted into the tibia bone cavity of rats to induce mechanical and thermal hyperalgesia. Read More

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http://dx.doi.org/10.1177/1744806919830240DOI Listing
February 2019
8 Reads
3.654 Impact Factor

[EXPRESS] Astrocyte activation in the periaqueductal gray promotes descending facilitation to cancer-induced bone pain through the JNK MAPK signaling pathway.

Mol Pain 2019 Jan 30:1744806919831909. Epub 2019 Jan 30.

The First Affiliated Hospital of Jiaxing University.

Descending nociceptive modulation from the supraspinal structures has an important role in cancer-induced bone pain (CIBP). Midbrain ventrolateral periaqueductal gray (vlPAG) is a critical component of descending nociceptive circuits; nevertheless, its precise cellular and molecular mechanisms involved in descending facilitation remain elusive. Our previous study has shown that activation of p38 MAPK in vlPAG microglia is essential for the neuropathic pain sensitization. Read More

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http://dx.doi.org/10.1177/1744806919831909DOI Listing
January 2019

TLR4 mediates upregulation and sensitization of TRPV1 in primary afferent neurons in 2,4,6-trinitrobenzene sulfate-induced colitis.

Mol Pain 2019 Jan-Dec;15:1744806919830018

1 Department of Anatomy and Physiology, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Elevated excitability of primary afferent neurons underlies chronic pain in patients with functional or inflammatory bowel diseases. Recent studies have established an essential role for an enhanced transient receptor potential vanilloid subtype 1 (TRPV1) signaling in mediating peripheral hyperalgesia in inflammatory conditions. Since colocalization of Toll-like receptor 4 (TLR4) and TRPV1 has been observed in primary afferents including the trigeminal sensory neurons and the dorsal root ganglion neurons, we test the hypothesis that TLR4 might regulate the expression and function of TRPV1 in primary afferent neurons in 2,4,6-trinitrobenzene sulfate (TNBS)-induced colitis using the TLR4-deficient and the wild-type C57 mice. Read More

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http://dx.doi.org/10.1177/1744806919830018DOI Listing
January 2019
3 Reads

ERK and p38 contribute to the regulation of nociceptin and the nociceptin receptor in human peripheral blood leukocytes.

Mol Pain 2019 Jan-Dec;15:1744806919828921

1 Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Little is known about the mechanisms involved in the regulation of nociceptin and its receptor (nociceptin opioid peptide receptor, NOP) in response to inflammation and pain in humans. In this study, specific signaling pathways contributing to the regulation of nociceptin and NOP in human peripheral blood leukocytes were investigated. After approval by the ethics committee, peripheral blood obtained from healthy donors was cultured with or without phorbol-12-myristate-13-acetate (PMA). Read More

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http://dx.doi.org/10.1177/1744806919828921DOI Listing
January 2019
4 Reads

Epigenetic control of hypersensitivity in chronic inflammatory pain by the de novo DNA methyltransferase Dnmt3a2.

Mol Pain 2019 Jan-Dec;15:1744806919827469

1 Department of Neurobiology, Interdisciplinary Centre for Neurosciences, Heidelberg University, Heidelberg, Germany.

Chronic pain is a pathological manifestation of neuronal plasticity supported by altered gene transcription in spinal cord neurons that results in long-lasting hypersensitivity. Recently, the concept that epigenetic regulators might be important in pathological pain has emerged, but a clear understanding of the molecular players involved in the process is still lacking. In this study, we linked Dnmt3a2, a synaptic activity-regulated de novo DNA methyltransferase, to chronic inflammatory pain. Read More

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http://dx.doi.org/10.1177/1744806919827469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362517PMC
January 2019
2 Reads

Differential regulation of GSK-3β in spinal dorsal horn and in hippocampus mediated by interleukin-1beta contributes to pain hypersensitivity and memory deficits following peripheral nerve injury.

Mol Pain 2019 Jan-Dec;15:1744806919826789

1 Pain Research Center and Department of Physiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

Accumulating evidence shows that inhibition of glycogen synthase kinase-3beta (GSK-3β) ameliorates cognitive impairments caused by a diverse array of diseases. Our previous work showed that spared nerve injury (SNI) that induces neuropathic pain causes short-term memory deficits. Here, we reported that GSK-3β activity was enhanced in hippocampus and reduced in spinal dorsal horn following SNI, and the changes persisted for at least 45 days. Read More

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http://dx.doi.org/10.1177/1744806919826789DOI Listing
January 2019
6 Reads

C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception.

Mol Pain 2019 Jan-Dec;15:1744806918825046

3 Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.

Sensitivity to different pain modalities has a genetic basis that remains largely unknown. Employing closely related inbred mouse substrains can facilitate gene mapping of nociceptive behaviors in preclinical pain models. We previously reported enhanced sensitivity to acute thermal nociception in C57BL/6J (B6J) versus C57BL/6N (B6N) substrains. Read More

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http://dx.doi.org/10.1177/1744806918825046DOI Listing
January 2019
1 Read

Fibromyalgia: Genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers.

Mol Pain 2019 Jan-Dec;15:1744806918819944. Epub 2018 Nov 29.

1 Anesthesiology, Critical Care and Pain Medicine Division, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Fibromyalgia is a disease characterized by chronic widespread pain with additional symptoms, such as joint stiffness, fatigue, sleep disturbance, cognitive dysfunction, and depression. Currently, fibromyalgia diagnosis is based exclusively on a comprehensive clinical assessment, according to 2016 ACR criteria, but validated biological biomarkers associated with fibromyalgia have not yet been identified. Genome-wide association studies investigated genes potentially involved in fibromyalgia pathogenesis highlighting that genetic factors are possibly responsible for up to 50% of the disease susceptibility. Read More

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http://dx.doi.org/10.1177/1744806918819944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322092PMC
November 2018
3 Reads

Evoked hypoalgesia is accompanied by tonic pain and immune cell infiltration in the dorsal root ganglia at late stages of diabetic neuropathy in mice.

Mol Pain 2018 Jan-Dec;14:1744806918817975. Epub 2018 Nov 20.

Institute of Pharmacology, Heidelberg University, Germany.

Diabetic peripheral neuropathy is a major debilitating late complication of diabetes, which significantly reduces the quality of life in patients. Diabetic peripheral neuropathy is associated with a wide spectrum of sensory abnormalities, where in loss of sensation or hypoalgesia to applied external stimuli is paradoxically accompanied by debilitating tonic spontaneous pain. In numerous studies on animal models of diabetic peripheral neuropathy, behavioural measurements have been largely confined to analysis of evoked withdrawal to mechanical and thermal stimuli applied to dermatomes, whereas spontaneous, on-going pain has not been widely studied. Read More

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http://journals.sagepub.com/doi/10.1177/1744806918817975
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http://dx.doi.org/10.1177/1744806918817975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311571PMC
November 2018
4 Reads

Ethanol-induced enhancement of inhibitory synaptic transmission in the rat spinal substantia gelatinosa.

Mol Pain 2018 Jan-Dec;14:1744806918817969. Epub 2018 Nov 19.

1 Department of Neurophysiology, Hyogo College of Medicine, Nishinomiya, Japan.

Recent studies have shown that ethanol produces a widespread modulation of neuronal activity in the central nervous system. It is not fully understood, however, how ethanol changes nociceptive transmission. We investigated acute effects of ethanol on synaptic transmission in the substantia gelatinosa (lamina II of the spinal dorsal horn) and mechanical responses in the spinal dorsal horn. Read More

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http://dx.doi.org/10.1177/1744806918817969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293375PMC
November 2018
9 Reads

RNA-seq of spinal cord from nerve-injured rats after spinal cord stimulation.

Mol Pain 2018 Jan-Dec;14:1744806918817429. Epub 2018 Nov 19.

3 Department of Anesthesia and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MA, USA.

Spinal cord stimulation has become an important modality in pain treatment especially for neuropathic pain conditions refractory to pharmacotherapy. However, the molecular control of inhibitory and excitatory mechanisms observed after spinal cord stimulation are poorly understood. Here, we used RNA-seq to identify differences in the expression of genes and gene networks in spinal cord tissue from nerve-injured rats with and without repetitive conventional spinal cord stimulation treatment. Read More

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http://journals.sagepub.com/doi/10.1177/1744806918817429
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http://dx.doi.org/10.1177/1744806918817429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293371PMC
November 2018
14 Reads
3.654 Impact Factor

Involvement of mGluR5 and TRPV1 in visceral nociception in a rat model of uterine cervical distension.

Mol Pain 2018 Jan-Dec;14:1744806918816850. Epub 2018 Nov 16.

1 Department of Anesthesia, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Metabotropic glutamate receptor 5 (mGluR5) and transient receptor potential vanilloid subtype 1 (TRPV1) have been shown to play critical roles in the transduction and modulation of cutaneous nociception in the central nervous system. However, little is known regarding the possible involvement of mGluR5 and TRPV1 in regulating visceral nociception from the uterine cervix. In this study, we used a rat model of uterine cervical distension to examine the effects of noxious stimuli to the uterine cervix on expression of spinal mGluR5 and TRPV1. Read More

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http://dx.doi.org/10.1177/1744806918816850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302284PMC
November 2018
16 Reads

Expression of mitochondrial dysfunction-related genes and pathways in paclitaxel-induced peripheral neuropathy in breast cancer survivors.

Mol Pain 2018 Jan-Dec;14:1744806918816462. Epub 2018 Nov 14.

1 School of Nursing, University of California, San Francisco, San Francisco, CA, USA.

Background: Paclitaxel is one of the most commonly used drugs to treat breast cancer. Its major dose-limiting toxicity is paclitaxel-induced peripheral neuropathy (PIPN). PIPN persists into survivorship and has a negative impact on patient's mood, functional status, and quality of life. Read More

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http://dx.doi.org/10.1177/1744806918816462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293373PMC
November 2018
21 Reads

Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional pain syndrome.

Mol Pain 2018 Jan-Dec;14:1744806918815005. Epub 2018 Nov 5.

1 Department of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.

Complex regional pain syndrome is an extremely painful condition that develops after trauma to a limb. Complex regional pain syndrome exhibits autoimmune features in part mediated by autoantibodies against muscarinic-2 acetylcholine (M2) receptor. The mechanisms underlying the M2 receptor involvement in complex regional pain syndrome remain obscure. Read More

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http://dx.doi.org/10.1177/1744806918815005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287297PMC
November 2018
7 Reads

A novel gain-of-function Na1.7 mutation in a carbamazepine-responsive patient with adult-onset painful peripheral neuropathy.

Mol Pain 2018 Jan-Dec;14:1744806918815007. Epub 2018 Nov 5.

1 Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.

Voltage-gated sodium channel Na1.7 is a threshold channel in peripheral dorsal root ganglion (DRG), trigeminal ganglion, and sympathetic ganglion neurons. Gain-of-function mutations in Na1. Read More

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http://journals.sagepub.com/doi/10.1177/1744806918815007
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http://dx.doi.org/10.1177/1744806918815007DOI Listing
November 2018
11 Reads

Differential modulation of voltage-gated sodium channels by nerve growth factor in three major subsets of TrkA-expressing nociceptors.

Mol Pain 2018 Jan-Dec;14:1744806918814640. Epub 2018 Nov 2.

1 Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.

Nerve growth factor is an inflammatory mediator that induces long-lasting hyperalgesia, which can partially be attributed to nerve growth factor-induced sensitization of primary afferent nociceptors. It was shown that nerve growth factor increases the excitability of polymodal C-fibre nociceptors by modulating tetrodotoxin-sensitive and tetrodotoxin-resistant voltage-gated sodium channels, but hitherto only little is known about the effects of nerve growth factor on sodium currents in other nociceptor subtypes that express the nerve growth factor receptor TrkA. We previously characterized two reporter mouse lines that allow the unequivocal identification of two important subclasses of TrkA-expressing nociceptors - i. Read More

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http://journals.sagepub.com/doi/10.1177/1744806918814640
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http://dx.doi.org/10.1177/1744806918814640DOI Listing
November 2018
2 Reads

Effects of cooling temperatures and low pH on membrane properties and voltage-dependent currents of rat nociceptive-like trigeminal ganglion neurons.

Mol Pain 2018 Jan-Dec;14:1744806918814350. Epub 2018 Oct 31.

1 Department of Anesthesiology and Perioperative Medicine, College of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Cooling temperatures and low pH have profound effects on somatosensory functions including nociception. The effects not only can be mediated by cooling temperature transducers and proton transducers expressed in subpopulations of somatosensory neurons but may also be mediated by ion channels involving membrane excitability such as voltage-dependent K channels in somatosensory neurons. In the present study, we performed the in situ patch-clamp recordings from nociceptive-like trigeminal ganglion neurons in ex vivo trigeminal ganglion preparations of adult rats. Read More

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http://dx.doi.org/10.1177/1744806918814350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249654PMC
October 2018
1 Read

Tetrahydroxystilbene glucoside relieves the chronic inflammatory pain by inhibiting neuronal apoptosis, microglia activation, and GluN2B overexpression in anterior cingulate cortex.

Mol Pain 2018 Jan-Dec;14:1744806918814367. Epub 2018 Nov 1.

1 Department of Orthopedics, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Tetrahydroxystilbene glucoside (THSG) is one of the active ingredients of Polygonum multiflorum. It has been shown to exert a variety of pharmacological effects, including antioxidant, anti-aging, and anti-atherosclerosis. Because of its prominent anti-inflammatory effect, we explored whether THSG had analgesic effect. Read More

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http://dx.doi.org/10.1177/1744806918814367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259074PMC
November 2018
5 Reads
3.654 Impact Factor

Analgesic effects of FAAH inhibitor in the insular cortex of nerve-injured rats.

Mol Pain 2018 Jan-Dec;14:1744806918814345. Epub 2018 Oct 31.

1 Department of Physiology and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.

The insular cortex is an important region of brain involved in the processing of pain and emotion. Recent studies indicate that lesions in the insular cortex induce pain asymbolia and reverse neuropathic pain. Endogenous cannabinoids (endocannabinoids), which have been shown to attenuate pain, are simultaneously degraded by fatty acid amide hydrolase (FAAH) that halts the mechanisms of action. Read More

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http://journals.sagepub.com/doi/10.1177/1744806918814345
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http://dx.doi.org/10.1177/1744806918814345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247483PMC
October 2018
8 Reads

Association of TRPV1 and TLR4 through the TIR domain potentiates TRPV1 activity by blocking activation-induced desensitization.

Mol Pain 2018 Jan-Dec;14:1744806918812636. Epub 2018 Oct 25.

1 Department of Neuroscience and Physiology, Dental Research Institute, School of Dentistry, Seoul National University, Republic of Korea.

Background: We have previously reported that histamine-induced pruritus was attenuated in toll-like receptor 4 (TLR4) knockout mice due to decreased transient receptor potential V1 (TRPV1) sensitivity. Our results implied that TLR4 potentiated TRPV1 activation in sensory neurons; however, the molecular mechanism has yet to be elucidated. In this study, we investigated the molecular mechanisms of TLR4-mediated TRPV1 potentiation using TLR4-deficient sensory neurons and a heterologous expression system. Read More

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http://dx.doi.org/10.1177/1744806918812636DOI Listing
October 2018
4 Reads

Etomidate and propylene glycol activate nociceptive TRP ion channels.

Mol Pain 2018 Jan-Dec;14:1744806918811699. Epub 2018 Oct 22.

1 Institute of Physiology and Pathophysiology, Friedrich-Alexander-University Erlangen-Nuernberg, Erlangen, Germany.

Background: Etomidate is a preferred drug for the induction of general anesthesia in cardiovascular risk patients. As with propofol and other perioperatively used anesthetics, the application of aqueous etomidate formulations causes an intensive burning pain upon injection. Such algogenic properties of etomidate have been attributed to the solubilizer propylene glycol which represents 35% of the solution administered clinically. Read More

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http://dx.doi.org/10.1177/1744806918811699DOI Listing
October 2018
12 Reads

Implication of microglia activation and CSF-1/CSF-1Rpathway in lumbar disc degeneration-related back pain.

Mol Pain 2018 Jan-Dec;14:1744806918811238. Epub 2018 Oct 17.

1 Spine Lab, Department of Orthopedic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Back pain is common and costly. Although lumbar disc degeneration has long been regarded as a major contributor to back pain, how disc degeneration leads to back pain remains unclear. Recent studies observed microglia activation in the spinal cord after disc degeneration, suggesting activated microglia may be involved in discogenic back pain. Read More

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http://dx.doi.org/10.1177/1744806918811238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243401PMC
October 2018
4 Reads

Cancer pain and neuropathic pain are associated with A β sensory neuronal plasticity in dorsal root ganglia and abnormal sprouting in lumbar spinal cord.

Mol Pain 2018 Jan-Dec;14:1744806918810099. Epub 2018 Oct 16.

1 Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, ON, Canada.

Evidence suggests that there are both nociceptive and neuropathic components of cancer-induced pain. We have observed that changes in intrinsic membrane properties and excitability of normally non-nociceptive Aβ sensory neurons are consistent in rat models of peripheral neuropathic pain and cancer-induced pain. This has prompted a comparative investigation of the intracellular electrophysiological characteristics of sensory neurons and of the ultrastructural morphology of the dorsal horn in rat models of neuropathic pain and cancer-induced pain. Read More

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http://dx.doi.org/10.1177/1744806918810099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243409PMC
October 2018
5 Reads

Pain-related white matter tract abnormalities in mild traumatic brain injury patients with persistent headache.

Mol Pain 2018 Jan-Dec;14:1744806918810297. Epub 2018 Oct 16.

2 Veteran Affairs San Diego Healthcare System, CA, USA.

Background: The occurrence of debilitating chronic persistent (24/7) headache after mild traumatic brain injury represents a central neuropathic pain state. Previous studies suggest that this chronic headache state can be attributed to altered supraspinal modulatory functional connectivity in both resting and evoked pain states. Abnormalities in the myelin sheaths along the supraspinal superior longitudinal fasciculus and anterior thalamic radiation are frequently associated with alteration in pain modulation related to functional connectivity deficit with the prefrontal cortex. Read More

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http://journals.sagepub.com/doi/10.1177/1744806918810297
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http://dx.doi.org/10.1177/1744806918810297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311536PMC
October 2018
10 Reads

Chronic myocardial infarction changed the excitatory-inhibitory synaptic balance in the medial prefrontal cortex of rat.

Authors:
Jing Li

Mol Pain 2018 Jan-Dec;14:1744806918809586. Epub 2018 Oct 10.

1 Department of Psychology, Institute of Public Health, Xi'an Medical University, Xi'an, China.

The medial prefrontal cortex is a key area for the regulation of pain and emotion. However, the functional involvement of the medial prefrontal cortex for visceral nociception, at the neuronal or synaptic level, is obscure yet. In the present study, the properties of excitatory and inhibitory synaptic transmission within the layer II/III of rat medial prefrontal cortex after chronic myocardial infarction were studied. Read More

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http://dx.doi.org/10.1177/1744806918809586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243403PMC
October 2018
11 Reads

A third HSAN5 mutation disrupts the nerve growth factor furin cleavage site.

Mol Pain 2018 Jan-Dec;14:1744806918809223. Epub 2018 Oct 8.

1 Cambridge Institute for Medical Research, Addenbrooke's Biomedical Research Centre, Cambridge, UK.

Bi-allelic dysfunctional mutations in nerve growth factor (NGF) cause the rare human phenotype hereditary sensory and autonomic neuropathy type 5 (HSAN5). We describe a novel NGF mutation in an individual with typical HSAN5 findings. The mutation c. Read More

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http://dx.doi.org/10.1177/1744806918809223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207963PMC
October 2018
8 Reads

Multimodal antidepressant vortioxetine causes analgesia in a mouse model of chronic neuropathic pain.

Mol Pain 2018 Jan-Dec;14:1744806918808987. Epub 2018 Oct 5.

1 Department of Physiology and Pharmacology, Sapienza University of Rome, Italy.

Vortioxetine is a multimodal antidepressant that potently antagonizes 5-HT3 serotonin receptors, inhibits the high-affinity serotonin transporter, activates 5-HT1A and 5-HT1B receptors, and antagonizes 5-HT1D and 5-HT7 receptors. 5-HT3 receptors largely mediate the hyperalgesic activity of serotonin that occurs in response to nerve injury. Activation of 5-HT3 receptors contributes to explain why selective serotonin reuptake inhibitors, such as fluoxetine, are not indicated in the treatment of neuropathic pain. Read More

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http://journals.sagepub.com/doi/10.1177/1744806918808987
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http://dx.doi.org/10.1177/1744806918808987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207957PMC
October 2018
15 Reads

[EXPRESS] CD11b activated Src signal attenuates neuroinflammatory pain by orchestrating inflammatory and anti-inflammatory cytokines in microglia.

Mol Pain 2018 Oct 3:1744806918808150. Epub 2018 Oct 3.

Changzheng Hospital.

Neuroinflammation plays an important role in the induction and maintenance of chronic pain. Orchestra of pattern-recognition receptors (PRRs) induced pro-inflammatory and anti-inflammatory cytokines are critical for inflammation homeostasis. CD11b on macrophages could inhibit toll like receptor (TLR) activation induced inflammatory responses. Read More

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http://journals.sagepub.com/doi/10.1177/1744806918808150
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http://dx.doi.org/10.1177/1744806918808150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311569PMC
October 2018
3 Reads

Mouse mast cells and mast cell proteases do not play a significant role in acute tissue injury pain induced by formalin.

Mol Pain 2018 Jan-Dec;14:1744806918808161. Epub 2018 Oct 3.

1 Department of Neuroscience, Developmental Genetics Unit, Uppsala University, Uppsala, Sweden.

Subcutaneous formalin injections are used as a model for tissue injury-induced pain where formalin induces pain and inflammation indirectly by crosslinking proteins and directly through activation of the transient receptor potential A1 receptor on primary afferents. Activation of primary afferents leads to both central and peripheral release of neurotransmitters. Mast cells are found in close proximity to peripheral sensory nerve endings and express receptors for neurotransmitters released by the primary afferents, contributing to the neuro/immune interface. Read More

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http://dx.doi.org/10.1177/1744806918808161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247485PMC
October 2018
1 Read

TLR4/NF-κB signaling activation in plantar tissue and dorsal root ganglion involves in the development of postoperative pain.

Mol Pain 2018 Jan-Dec;14:1744806918807050. Epub 2018 Oct 1.

1 Department of Anesthesiology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.

Background Severe postoperative pain remains a clinical problem that impacts patient's rehabilitation. The present work aims to investigate the role of Toll-like receptor-4 (TLR4) activation in wounded plantar tissue and dorsal root ganglion (DRG) in the genesis of postoperative pain and its underlying mechanisms. Results Postoperative pain was induced by plantar incision in rat hind paw. Read More

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http://journals.sagepub.com/doi/10.1177/1744806918807050
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http://dx.doi.org/10.1177/1744806918807050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196615PMC
January 2019
15 Reads
3.650 Impact Factor

Predominant synaptic potentiation and activation in the right central amygdala are independent of bilateral parabrachial activation in the hemilateral trigeminal inflammatory pain model of rats.

Mol Pain 2018 Jan-Dec;14:1744806918807102. Epub 2018 Oct 1.

1 Department of Neuroscience, Jikei University School of Medicine, Tokyo, Japan.

Nociceptive signals originating in the periphery are conveyed to the brain through specific afferent and ascending pathways. The spino-(trigemino-)parabrachio-amygdaloid pathway is one of the principal pathways mediating signals from nociception-specific ascending neurons to the central amygdala, a limbic structure involved in aversive signal-associated emotional responses, including the emotional aspects of pain. Recent studies suggest that the right and left central amygdala play distinct roles in the regulation of nociceptive responses. Read More

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http://dx.doi.org/10.1177/1744806918807102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243415PMC
October 2018
1 Read

Bone Morphogenetic Protein Glass Bottom Boat (BMP5/6/7/8) and its receptor Wishful Thinking (BMPRII) are required for injury-induced allodynia in Drosophila.

Mol Pain 2018 Jan-Dec;14:1744806918802703

1 Department of Biology, College of Arts and Sciences, Center for Excellence in the Neurosciences, University of New England, Biddeford, ME, USA.

Background Chronic pain affects millions of people worldwide; however, its cellular and molecular mechanisms have not been completely elucidated. It is thought that chronic pain is triggered by nociceptive sensitization, which produces elevated nocifensive responses. A model has been developed in Drosophila melanogaster to investigate the underlying mechanisms of chronic pain using ultraviolet-induced tissue injury to trigger thermal allodynia, a nociceptive hypersensitivity to a normally innocuous stimulus. Read More

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http://dx.doi.org/10.1177/1744806918802703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161205PMC
January 2019
1 Read

Surgical incision induces learning impairment in mice partially through inhibition of the brain-derived neurotrophic factor signaling pathway in the hippocampus and amygdala.

Mol Pain 2018 Jan-Dec;14:1744806918805902. Epub 2018 Sep 20.

4 Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China.

Surgical incision-induced nociception contributes to the occurrence of postoperative cognitive dysfunction. However, the exact mechanisms involved remain unclear. Brain-derived neurotrophic factor (BDNF) has been demonstrated to improve fear learning ability. Read More

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http://dx.doi.org/10.1177/1744806918805902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194924PMC
January 2019
1 Read

Fear extinction learning ability predicts neuropathic pain behaviors and amygdala activity in male rats.

Mol Pain 2018 Jan-Dec;14:1744806918804441. Epub 2018 Sep 13.

1 Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX, USA.

Background The amygdala plays a key role in fear learning and extinction and has emerged as an important node of emotional-affective aspects of pain and pain modulation. Impaired fear extinction learning, which involves prefrontal cortical control of amygdala processing, has been linked to neuropsychiatric disorders. Here, we tested the hypothesis that fear extinction learning ability can predict the magnitude of neuropathic pain. Read More

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http://journals.sagepub.com/doi/10.1177/1744806918804441
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http://dx.doi.org/10.1177/1744806918804441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172937PMC
January 2019
2 Reads

Effect of single-nucleotide polymorphisms in TRPV1 on burning pain and capsaicin sensitivity in Japanese adults.

Mol Pain 2018 Jan-Dec;14:1744806918804439. Epub 2018 Sep 13.

1 Department of Oral and Maxillofacial Biology, Graduate School of Oral Medicine, Matsumoto Dental University, Shiojiri, Japan.

Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel that is expressed in the sensory neurons and responds to various noxious stimuli including heat and capsaicin. The molecular properties of TRPV1 have been clearly examined; however, there are obvious individual differences in human sensitivity to thermal stimuli and capsaicin. Here, we examined the possibility that different genome sequence of human TRPV1 caused the different sensitivity to heat or capsaicin. Read More

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http://dx.doi.org/10.1177/1744806918804439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180359PMC
January 2019
7 Reads

Activation of the P2X receptor in midbrain periaqueductal gray participates in the analgesic effect of tramadol in bone cancer pain rats.

Mol Pain 2018 Jan-Dec;14:1744806918803039. Epub 2018 Sep 10.

3 Research Center for Medicine and Biology, Zunyi Medical University, Zunyi, Guizhou, China.

Background Cancer pain is a well-known serious complication in metastatic or terminal cancer patients. Current pain management remains unsatisfactory. The activation of spinal and supraspinal P2X receptors plays a crucial role in the induction and maintenance mechanisms of various kinds of acute or chronic pain. Read More

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http://dx.doi.org/10.1177/1744806918803039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176534PMC
January 2019
9 Reads
3.654 Impact Factor

Mechanisms for therapeutic effect of bulleyaconitine A on chronic pain.

Mol Pain 2018 Jan-Dec;14:1744806918797243

2 Pain Research Center, Sun Yat-sen University, Guangzhou, China.

Bulleyaconitine A, a diterpenoid alkaloid isolated from Aconitum bulleyanum plants, has been used for the treatment of chronic pain in China since 1985. Clinical studies show that the oral administration of bulleyaconitine A is effective for treating different kinds of chronic pain, including back pain, joint pain, and neuropathic pain with minimal side effect in human patients. The experimental studies have revealed that bulleyaconitine A at therapeutic doses potently inhibits the peripheral sensitization and central sensitization that underlie chronic pain and has no effect on acute pain. Read More

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http://dx.doi.org/10.1177/1744806918797243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125851PMC
January 2019
11 Reads

Histone deacetylase inhibitors prevent persistent hypersensitivity in an orofacial neuropathic pain model.

Mol Pain 2018 Jan-Dec;14:1744806918796763

2 Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.

Chronic orofacial pain is a significant health problem requiring identification of regulating processes. Involvement of epigenetic modifications that is reported for hindlimb neuropathic pain experimental models, however, is less well studied in cranial nerve pain models. Three independent observations reported here are the (1) epigenetic profile in mouse trigeminal ganglia (TG) after trigeminal inflammatory compression (TIC) nerve injury mouse model determined by gene expression microarray, (2) H3K9 acetylation pattern in TG by immunohistochemistry, and (3) efficacy of histone deacetylase (HDAC) inhibitors to attenuate development of hypersensitivity. Read More

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http://dx.doi.org/10.1177/1744806918796763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124181PMC
January 2019
13 Reads

ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability.

Mol Pain 2018 Jan-Dec;14:1744806918801224. Epub 2018 Aug 29.

1 Biochemistry Interdisciplinary Graduate Program, Molecular and Cellular Biochemistry Department, Indiana University, Bloomington, IN, USA.

Elevated N-methyl-D-aspartate receptor activity contributes to central sensitization. Our laboratories and others recently reported that disrupting protein-protein interactions downstream of N-methyl-D-aspartate receptors suppresses pain. Specifically, disrupting binding between the enzyme neuronal nitric oxide synthase and either its upstream (postsynaptic density 95 kDa, PSD95) or downstream (e. Read More

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http://dx.doi.org/10.1177/1744806918801224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144507PMC
January 2019
3 Reads

Two isoforms of cyclic GMP-dependent kinase-I exhibit distinct expression patterns in the adult mouse dorsal root ganglion.

Mol Pain 2018 Jan-Dec;14:1744806918796409

1 Department of Medical Chemistry, Kansai Medical University, Japan.

cGMP-dependent kinase-I (cGKI) is known to regulate spinal pain processing. This enzyme consists of two isoforms (cGKIα and cGKIβ) that show distinct substrate specificity and tissue distribution. It has long been believed that the α isoform is exclusively expressed in the adult dorsal root ganglion. Read More

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http://dx.doi.org/10.1177/1744806918796409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113733PMC
December 2018
2 Reads

Correlation of TGN-020 with the analgesic effects via ERK pathway activation after chronic constriction injury.

Mol Pain 2018 Jan-Dec;14:1744806918796057

1 Department of Human Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China.

Extracellular regulated protein kinase (ERK) pathway activation in astrocytes and neurons has been reported to be critical for neuropathic pain development after chronic constriction injury. TGN-020 was found to be the most potent aquaporin 4 inhibitor among the agents studied. The present study aimed to assess whether the inhibition of aquaporin 4 had an analgesic effect on neuropathic pain and whether the inhibition of astrocytic activation and ERK pathway was involved in the analgesic effect of TGN-020. Read More

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http://journals.sagepub.com/doi/10.1177/1744806918796057
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http://dx.doi.org/10.1177/1744806918796057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113736PMC
December 2018
17 Reads

Mitochondrial superoxide increases excitatory synaptic strength in spinal dorsal horn neurons of neuropathic mice.

Mol Pain 2018 Jan-Dec;14:1744806918797032

1 Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, TX, USA.

Reactive oxygen species has been suggested as a key player in neuropathic pain, causing central sensitization by changing synaptic strengths in spinal dorsal horn neurons. However, it remains unclear as to what type of reactive oxygen species changes what aspect of synaptic strengths for central sensitization in neuropathic pain conditions. In this study, we investigated whether mitochondrial superoxide affects both excitatory and inhibitory synaptic strengths in spinal dorsal horn neurons after peripheral nerve injury. Read More

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http://dx.doi.org/10.1177/1744806918797032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113735PMC
December 2018
7 Reads

Clinical, electrophysiological, and cutaneous innervation changes in patients with bortezomib-induced peripheral neuropathy reveal insight into mechanisms of neuropathic pain.

Mol Pain 2018 Jan-Dec;14:1744806918797042

1 Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.

Bortezomib is a mainstay of therapy for multiple myeloma, frequently complicated by painful neuropathy. The objective of this study was to describe clinical, electrophysiological, and pathological changes of bortezomib-induced peripheral neuropathy (BiPN) in detail and to correlate pathological changes with pain descriptors. Clinical data, nerve conduction studies, and lower leg skin biopsies were collected from 22 BiPN patients. Read More

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http://dx.doi.org/10.1177/1744806918797042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113731PMC
December 2018
2 Reads

P2X4-receptor participates in EAAT3 regulation via BDNF-TrkB signaling in a model of trigeminal allodynia.

Mol Pain 2018 Jan-Dec;14:1744806918795930

1 Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Objective Previous studies of neuropathic pain have suggested that the P2X4 purinoceptor (P2X4R) in spinal microglia is essential for maintaining allodynia following nerve injury. However, little is known about its role in inflammatory soup-induced trigeminal allodynia, which closely mimics chronic migraine status. Here, we determined the contributions of P2X4R and related signaling pathways in an inflammatory soup-induced trigeminal allodynia model. Read More

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http://dx.doi.org/10.1177/1744806918795930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111400PMC
December 2018
18 Reads

Intrathecal delivery of a palmitoylated peptide targeting Y382-384 within the P2X7 receptor alleviates neuropathic pain.

Mol Pain 2018 Jan-Dec;14:1744806918795793

1 Department of Comparative Biology & Experimental Medicine, University of Calgary, Calgary, Alberta, Canada.

Pain hypersensitivity resulting from peripheral nerve injury depends on pathological microglial activation in the dorsal horn of the spinal cord. This microglial activity is critically modulated by P2X7 receptors (P2X7R) and ATP stimulation of these receptors produces mechanical allodynia, a defining feature of neuropathic pain. Peripheral nerve injury increases P2X7R expression and potentiates its cation channel function in spinal microglia. Read More

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http://dx.doi.org/10.1177/1744806918795793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111392PMC
December 2018
9 Reads

Neuritis and vinblastine-induced axonal transport disruption lead to signs of altered dorsal horn excitability.

Mol Pain 2018 Jan-Dec;14:1744806918799581. Epub 2018 Aug 21.

1 Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, UK.

Background: Many patients with neuropathic pain present without signs of nerve injury on routine clinical examination. Some of these patients may have inflamed peripheral nerves (neuritis). In this study, we have examined whether neuritis causes changes within the dorsal horn that may contribute to a central pain mechanism. Read More

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http://dx.doi.org/10.1177/1744806918799581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243410PMC
August 2018
2 Reads

Autoinflammatory and autoimmune contributions to complex regional pain syndrome.

Mol Pain 2018 Jan-Dec;14:1744806918799127. Epub 2018 Aug 20.

3 Palo Alto Veterans Institute for Research, Palo Alto, CA, USA.

Complex regional pain syndrome (CRPS) is a highly enigmatic syndrome typically developing after injury or surgery to a limb. Severe pain and disability are common among those with chronic forms of this condition. Accumulating evidence suggests that CRPS may involve both autoinflammatory and autoimmune components. Read More

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http://journals.sagepub.com/doi/10.1177/1744806918799127
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http://dx.doi.org/10.1177/1744806918799127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125849PMC
January 2019
22 Reads

The etiological changes of acetylation in peripheral nerve injury-induced neuropathic hypersensitivity.

Mol Pain 2018 Jan-Dec;14:1744806918798408. Epub 2018 Aug 14.

1 Department of Anesthesiology, Obstetrics and Gynecology Hospital, Affiliated to Nanjing Medical University, Nanjing, China.

Neuropathic pain is a common chronic pain condition with mechanisms far clearly been elucidated. Mounting preclinical and clinical studies have shown neuropathic pain is highly associated with histone acetylation modification, which follows expression regulation of various pain-related molecules such as mGluR1/5, glutamate aspartate transporter, glutamate transporter-1, GAD65, Na1.8, Kv4. Read More

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http://dx.doi.org/10.1177/1744806918798408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144590PMC
January 2019
24 Reads
3.654 Impact Factor

Heterosynaptic long-term potentiation from the anterior cingulate cortex to spinal cord in adult rats.

Mol Pain 2018 Jan-Dec;14:1744806918798406. Epub 2018 Aug 14.

1 Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi'an Jiaotong University, Xi'an, China.

Spinal nociceptive transmission receives biphasic modulation from supraspinal structures. Recent studies demonstrate that the anterior cingulate cortex facilitates spinal excitatory synaptic transmission and nociceptive reflex. However, whether the top-down descending facilitation can cause long-term synaptic changes in spinal cord remains unclear. Read More

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http://dx.doi.org/10.1177/1744806918798406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311562PMC
August 2018
5 Reads