2,185 results match your criteria Molecular Cancer [Journal]


A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis.

Mol Cancer 2019 Feb 19;18(1):28. Epub 2019 Feb 19.

Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi Province, China.

Background: Hepatocellular carcinoma (HCC) is the most common malignant liver tumor with poor clinical outcomes. Increasing amount of long non-coding RNAs (lncRNAs) have been revealed to be implicated in the carcinogenesis and progression of HCC. However, the expressions, clinical significances, and roles of most lncRNAs in HCC are still unknown. Read More

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http://dx.doi.org/10.1186/s12943-019-0957-7DOI Listing
February 2019

Targeting PI3K in cancer: mechanisms and advances in clinical trials.

Mol Cancer 2019 Feb 19;18(1):26. Epub 2019 Feb 19.

Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling is one of the most important intracellular pathways, which can be considered as a master regulator for cancer. Enormous efforts have been dedicated to the development of drugs targeting PI3K signaling, many of which are currently employed in clinical trials evaluation, and it is becoming increasingly clear that PI3K inhibitors are effective in inhibiting tumor progression. PI3K inhibitors are subdivided into dual PI3K/mTOR inhibitors, pan-PI3K inhibitors and isoform-specific inhibitors. Read More

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http://dx.doi.org/10.1186/s12943-019-0954-xDOI Listing
February 2019

Circular RNA cTFRC acts as the sponge of MicroRNA-107 to promote bladder carcinoma progression.

Mol Cancer 2019 Feb 19;18(1):27. Epub 2019 Feb 19.

Department of urology, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, 646699, China.

Background: Circular RNA (circRNA) represents a broad and diverse endogenous RNAs that can regulate gene expression in cancer. However, the regulation and function of bladder cancer (BC) circRNAs remain largely unknown.

Methods: Here we generated circRNA microarray data from three BC tissues and paired non-cancerous matched tissues, and detected circular RNA-cTFRC up-regulated and correlated with tumor grade and poor survival rate of BC patients. Read More

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http://dx.doi.org/10.1186/s12943-019-0951-0DOI Listing
February 2019

CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p.

Mol Cancer 2019 Feb 18;18(1):25. Epub 2019 Feb 18.

Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

Background: Circular RNAs (circRNAs) are a class of non-coding RNAs with a loop structure, but its functions remain largely unknown. Growing evidence has revealed that circRNAs play a striking role as functional RNAs in the progression of malignant disease. However, the precise role of circRNAs in gastric cancer (GC) remains unclear. Read More

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http://dx.doi.org/10.1186/s12943-019-0958-6DOI Listing
February 2019

Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas.

Mol Cancer 2019 Feb 11;18(1):24. Epub 2019 Feb 11.

Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan.

Axl receptor tyrosine kinase is involved in the growth and metastasis and is an indicator of poor prognosis in several cancers including lung cancers. Although a mitogen-activated protein kinase (MAPK) pathway and an epithelial-to-mesenchymal transition (EMT) program are critical, molecular mechanisms underlying the Axl-driven cancer progression have not been fully elucidated. We aimed to identify molecules up-regulated by Axl kinase in lung adenocarcinomas. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-019-0953-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369543PMC
February 2019
2 Reads

circKIF4A acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer.

Mol Cancer 2019 Feb 11;18(1):23. Epub 2019 Feb 11.

Department of Breast Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, 651 East Dongfeng Road, Guangzhou, 510060, China.

Background: Increasing studies has found that circular RNAs (circRNAs) play vital roles in cancer progression. But the expression profile and function of circRNAs in triple-negative breast cancer (TNBC) are unclear.

Methods: We used a circRNA microarray to explore the circRNA expression profile of TNBC. Read More

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http://dx.doi.org/10.1186/s12943-019-0946-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369546PMC
February 2019

Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NFκB/c-Myc signaling in female esophageal carcinoma.

Mol Cancer 2019 Feb 8;18(1):22. Epub 2019 Feb 8.

Department of Genetics, Medical College of Soochow University, Suzhou, 215123, China.

Background: Though esophageal cancer is three to four times more common among males than females worldwide, this type of cancer still ranks in the top incidence among women, even more than the female specific cancer types. The occurrence is currently attributed to extrinsic factors, including tobacco use and alcohol consumption. However, limited attention has been given to gender-specific intrinsic genetic factors, especially in female. Read More

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http://dx.doi.org/10.1186/s12943-019-0949-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367809PMC
February 2019
1 Read
4.257 Impact Factor

Bevacizumab treatment for radiation brain necrosis: mechanism, efficacy and issues.

Mol Cancer 2019 Feb 7;18(1):21. Epub 2019 Feb 7.

Department of Radiation Oncology, Division of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, TX77054, USA.

Vascular damage is followed by vascular endothelial growth factor (VEGF) expression at high levels, which is an important mechanism forradiation brain necrosis development. Bevacizumab alleviates brain edema symptoms caused by radiation brain necrosis through inhibiting VEGF and acting on vascular tissue around the brain necrosis area. Many studies have confirmed that bevacizumab effectively relieves symptoms caused by brain necrosis, improves patients' Karnofsky performance status (KPS) scores and brain necrosis imaging. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-019-0950-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367784PMC
February 2019
2 Reads

Transcriptomic expression profiling identifies ITGBL1, an epithelial to mesenchymal transition (EMT)-associated gene, is a promising recurrence prediction biomarker in colorectal cancer.

Mol Cancer 2019 Feb 4;18(1):19. Epub 2019 Feb 4.

Center for Gastrointestinal Research, Center for Translational Genomics and Oncology, Baylor Scott & White Research Institute and Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, 3410 Worth Street, Suite 610, Dallas, TX, 75246, USA.

The current histopathological risk-stratification criteria in colorectal cancer (CRC) patients following a curative surgery remain inadequate. In this study, we undertook a systematic, genomewide, biomarker discovery approach to identify and validate key EMT-associated genes that may facilitate recurrence prediction in CRC. Genomewide RNA expression profiling results from two datasets (GSE17538; N = 173 and GSE41258; N = 307) were used for biomarker discovery. Read More

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http://dx.doi.org/10.1186/s12943-019-0945-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360655PMC
February 2019

Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway.

Mol Cancer 2019 Feb 4;18(1):20. Epub 2019 Feb 4.

Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.

Background: CircRNA has emerged as a new non-coding RNA that plays crucial roles in tumour initiation and development. 'MiRNA sponge' is the most reported role played by circRNAs in many tumours. The AKT/mTOR axis is a classic signalling pathway in cancers that sustains energy homeostasis through energy production activities, such as the Warburg effect, and blocks catabolic activities, such as autophagy. Read More

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http://dx.doi.org/10.1186/s12943-018-0935-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360801PMC
February 2019

Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis.

Mol Cancer 2019 Jan 31;18(1):18. Epub 2019 Jan 31.

State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, 800 Dongchuan Road, Shanghai, 200240, People's Republic of China.

Background: Lysyl oxidase-like 4 (LOXL4) has been found to be dysregulated in several human malignancies, including hepatocellular carcinoma (HCC). However, the role of LOXL4 in HCC progression remains largely unclear. In this study, we investigated the clinical significance and biological involvement of LOXL4 in the progression of HCC. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-019-0948-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354392PMC
January 2019
4 Reads
4.257 Impact Factor

The relationship between autophagy and the immune system and its applications for tumor immunotherapy.

Mol Cancer 2019 01 24;18(1):17. Epub 2019 Jan 24.

Key Laboratory of Biomedical Imaging of Guangdong Province, Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China.

Autophagy is a genetically well-controlled cellular process that is tightly controlled by a set of core genes, including the family of autophagy-related genes (ATG). Autophagy is a "double-edged sword" in tumors. It can promote or suppress tumor development, which depends on the cell and tissue types and the stages of tumor. Read More

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http://dx.doi.org/10.1186/s12943-019-0944-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345046PMC
January 2019
2 Reads

Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis.

Mol Cancer 2019 01 23;18(1):16. Epub 2019 Jan 23.

Department of Radiation Oncology, Shandong Cancer Hospital affiliated to Shandong University, Jinan, 250117, China.

Esophageal squamous cell cancer (ESCC) is a high incidence and mortality disease worldwide. However, specificity and sensitivity of its diagnostic and prognostic biomarkers are still unsatisfactory. Recently, circular RNAs (circRNAs) as biomarkers have been studied extensively while the expression profile and clinical significance of circRNAs in ESCC have rarely been studied. Read More

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http://dx.doi.org/10.1186/s12943-018-0936-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343327PMC
January 2019
1 Read

Novel long noncoding RNA OTUD6B-AS1 indicates poor prognosis and inhibits clear cell renal cell carcinoma proliferation via the Wnt/β-catenin signaling pathway.

Mol Cancer 2019 01 22;18(1):15. Epub 2019 Jan 22.

Department of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China.

Background: The long noncoding RNA (lncRNA) OTUD6B antisense RNA 1 (OTUD6B-AS1) is oriented in an antisense direction to the protein-coding gene OTUD6B on the opposite DNA strand. TCGA database data show that the expression of the lncRNA OTUD6B-AS1 is downregulated and that OTUD6B-AS1 acts as an antioncogene in a variety of tumors. However, the expression and biological functions of the lncRNA OTUD6B-AS1 are still unknown in tumors, including clear cell renal cell carcinoma (ccRCC). Read More

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http://dx.doi.org/10.1186/s12943-019-0942-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341572PMC
January 2019
4 Reads
4.257 Impact Factor

Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer.

Mol Cancer 2019 01 21;18(1):13. Epub 2019 Jan 21.

State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, People's Republic of China.

Circular RNAs are widely expressed in eukaryotic cells and associated with cancer. However, limited studies to date have focused on the potential role of circRNAs in progression of lung cancer. Data from the current investigation showed that circRNA 100146 is highly expressed in non-small cell lung cancer (NSCLC) cell lines and the chemically induced malignant transformed bronchial cell line, 16HBE-T, as well as 40 paired tissue samples of NSCLC. Read More

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http://dx.doi.org/10.1186/s12943-019-0943-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340182PMC
January 2019
2 Reads

Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis.

Mol Cancer 2019 01 21;18(1):14. Epub 2019 Jan 21.

Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE, 68198-6805, USA.

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation and related mechanisms has led researchers to focus on the microenvironment where pancreatic cancers develop. The anomalous proliferation of stromal cells, such as pancreatic stellate cells, and an increased deposition of altered matrix proteins create an environment that facilitates tumor growth, metastasis and drug resistance. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-018-0927-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341551PMC
January 2019
5 Reads

The functional role of integrins during intra- and extravasation within the metastatic cascade.

Mol Cancer 2019 01 18;18(1):12. Epub 2019 Jan 18.

Institute of Anatomy and Experimental Morphology, University Cancer Center, University Medical Center Hamburg Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

Formation of distant metastases is by far the most common cause of cancer-related deaths. The process of metastasis formation is complex, and within this complex process the formation of migratory cells, the so called epithelial mesenchymal transition (EMT), which enables cancer cells to break loose from the primary tumor mass and to enter the bloodstream, is of particular importance. To break loose from the primary cancer, cancer cells have to down-regulate the cell-to-cell adhesion molecuIes (CAMs) which keep them attached to neighboring cancer cells. Read More

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http://dx.doi.org/10.1186/s12943-018-0937-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337777PMC
January 2019
2 Reads

N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway.

Mol Cancer 2019 01 18;18(1):11. Epub 2019 Jan 18.

Department of Pathology, Duke Unversity School of Medicine, DUMC box 103864, 905 S. Lasalle Street, Durham, NC, 27710, USA.

Background: MYCN amplification or N-Myc overexpression is found in approximately 40% NEPC and up to 20% CRPC patients. N-Myc has been demonstrated to drive disease progression and hormonal therapeutic resistance of NEPC/CRPC. Here, we aim to identify the molecular mechanisms underlying the N-Myc-driven therapeutic resistance and provide new therapeutic targets for those N-Myc overexpressed NEPC/CRPC. Read More

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http://dx.doi.org/10.1186/s12943-019-0941-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337850PMC
January 2019
4 Reads
4.257 Impact Factor

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape.

Mol Cancer 2019 01 15;18(1):10. Epub 2019 Jan 15.

NHC Key Laboratory of Carcinogenesis (Central South University) and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.

Tumor immune escape is an important strategy of tumor survival. There are many mechanisms of tumor immune escape, including immunosuppression, which has become a research hotspot in recent years. The programmed death ligand-1/programmed death-1 (PD-L1/PD-1) signaling pathway is an important component of tumor immunosuppression, which can inhibit the activation of T lymphocytes and enhance the immune tolerance of tumor cells, thereby achieving tumor immune escape. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-018-0928-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332843PMC
January 2019
9 Reads

PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA.

Mol Cancer 2019 01 12;18(1). Epub 2019 Jan 12.

State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Background: Breast cancer is one of the most common malignancies and the major cause of cancer-related death in women. Although the importance of PIWI-interacting RNAs (piRNAs) in cancer has been increasingly recognized, few studies have been explored the functional mechanism of piRNAs in breast cancer development and progression.

Methods: We examined the top 20 highly expressed piRNAs based on the analysis of TCGA breast cancer data in two patient cohorts to test the roles of piRNAs in breast cancer. Read More

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http://dx.doi.org/10.1186/s12943-019-0940-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330501PMC
January 2019
2 Reads

RNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers.

Mol Cancer 2019 01 10;18(1). Epub 2019 Jan 10.

Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

In this study, the secondary sequencing was used to profile circRNA expression in the tissue samples from three CRC patients with liver metastasis and three matched CRC patients. After verified some candidates in another 40 CRC and CRC-m samples by qRT-PCR, we further demonstrated that circRNA_0001178 and circRNA_0000826 were significantly upregulated in CRC-m tissues, and both of them had the potential for diagnosing liver metastases from colorectal cancer. Finally, the networks of circRNA-miRNA-mRNA base on these two circRNAs were constructed respectively. Read More

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http://dx.doi.org/10.1186/s12943-018-0932-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327571PMC
January 2019
1 Read

Intratumor heterogeneity comparison among different subtypes of non-small-cell lung cancer through multi-region tissue and matched ctDNA sequencing.

Mol Cancer 2019 01 9;18(1). Epub 2019 Jan 9.

Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou, Guangdong, 510060, People's Republic of China.

Understanding of intratumor heterogeneity (ITH) among different non-small cell lung cancer (NSCLC) subtypes is necessary. Whether circulating tumor DNA (ctDNA) profile could represent these ITH is still an open question. We performed 181 multi-region tumor tissues sequencing and matched ctDNA sequencing from 32 operative NSCLC to compare ITH among different NSCLC subtypes, including EGFR-mutant lung adenocarcinoma (LUAD), KRAS-mutant LUAD, EGFR&KRAS-wild-type LUAD, and lung squamous cell carcinoma (LUSC), and examine potential value of ctDNA for ITH analysis. Read More

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http://dx.doi.org/10.1186/s12943-019-0939-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325778PMC
January 2019
2 Reads

The novel roles of circRNAs in human cancer.

Mol Cancer 2019 01 9;18(1). Epub 2019 Jan 9.

Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 12, Lane 833, Zhizaoju Road, Huangpu District, Shanghai, 200001, China.

Covalently closed single-stranded circular RNAs (circRNAs) consist of introns or exons and are widely present in eukaryotic cells. CircRNAs generally have low expression levels and relatively stable structures compared with messenger RNAs (mRNAs), most of which are located in the cytoplasm and often act in cell type and tissue-specific manners, indicating that they may serve as novel biomarkers. In recent years, circRNAs have gradually become a hotspot in the field of RNA and cancer research, but the functions of most circRNAs have not yet been discovered. Read More

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http://dx.doi.org/10.1186/s12943-018-0934-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325800PMC
January 2019
2 Reads

The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis.

Authors:
Paul Laissue

Mol Cancer 2019 01 8;18(1). Epub 2019 Jan 8.

Center For Research in Genetics and Genomics-CIGGUR, GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 N° 63C-69, Bogotá, Colombia.

Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the fourth most frequent cause of death having an oncological origin. It has been found that transcription factors (TF) dysregulation, leading to the significant expression modifications of genes, is a widely distributed phenomenon regarding human malignant neoplasias. These changes are key determinants regarding tumour's behaviour as they contribute to cell differentiation/proliferation, migration and metastasis, as well as resistance to chemotherapeutic agents. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-019-0938-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325735PMC
January 2019
4 Reads

The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression.

Mol Cancer 2019 01 8;18(1). Epub 2019 Jan 8.

Department of Cell Biology and Genetics, Chongqing Medical University, #1 Yixueyuan Road, Chongqing, 400016, China.

Background: In recent years, circular RNAs (circRNAs), a new star of non-coding RNA, have been emerged as vital regulators and gained much attention for involvement of initiation and progression of diverse kinds of human diseases, especially cancer. However, regulatory role, clinical significance and underlying mechanisms of circRNAs in triple-negative breast cancer (TNBC) still remain largely unknown.

Methods: Here, the expression profile of circRNAs in 4 pairs of TNBC tissues and adjacent non-tumor tissues was analyzed by RNA-sequencing. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-018-0933-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325825PMC
January 2019
9 Reads

Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast Cancer.

Mol Cancer 2019 01 8;18(1). Epub 2019 Jan 8.

Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Background: Trastuzumab resistance followed by metastasis is a major obstacle for improving the clinical outcome of patients with advanced human epidermal growth factor receptor 2-positive (HER-2+) breast cancer. While long non-coding RNAs (lncRNAs) can modulate cell behavior, the contribution of these RNAs in trastuzumab resistance and metastasis of HER-2+ breast cancer is not well known. In this study, we sought to identify the regulatory role of lncRNA in trastuzumab resistance and accompanied Epithelial-mesenchymal Transition (EMT) process in advanced HER-2+ breast cancer. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-018-0931-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323810PMC
January 2019
2 Reads

Low levels of tumour suppressor miR-655 in plasma contribute to lymphatic progression and poor outcomes in oesophageal squamous cell carcinoma.

Mol Cancer 2019 01 4;18(1). Epub 2019 Jan 4.

Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachihirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Recent studies identified that low levels of tumour suppressor microRNAs (miRNAs) in plasma/serum relate to tumour progression and poor outcomes in cancers. We selected six candidates (miR-126, 133b, 143, 203, 338-3p, 655) of tumour suppressor miRNAs in oesophageal squamous cell carcinoma (ESCC) by a systematic review of NCBI database. Of these, miR-655 levels were significantly down-regulated in plasma of ESCC patients compared to healthy volunteers by test- and validation-scale analyses. Read More

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http://dx.doi.org/10.1186/s12943-018-0929-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320607PMC
January 2019
2 Reads

Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression.

Mol Cancer 2019 01 4;18(1). Epub 2019 Jan 4.

Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, 832002, China.

Background: Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, and serves as a conduit for migration. Targeting oncogenes involved in angiogenesis is needed to treat organ-confined and locally advanced ESCC. Read More

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http://dx.doi.org/10.1186/s12943-018-0930-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320601PMC
January 2019
3 Reads
4.257 Impact Factor

Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy.

Mol Cancer 2018 12 28;17(1):178. Epub 2018 Dec 28.

Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, 467 Zhongshan Road, Dalian, 116027, Liaoning, China.

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with high morbidity, relapse and mortality rates. Multipotent mesenchymal stromal cells (MSCs) can be recruited to and become integral components of the HCC microenvironment and can influence tumor progression. This review discusses MSC migration to liver fibrosis and the HCC microenvironment, MSC involvement in HCC initiation and progression and the widespread application of MSCs in HCC-targeted therapy, thus clarifying the critical roles of MSCs in HCC. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-018-0926-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309092PMC
December 2018
6 Reads

Comparative proteogenomic analysis of right-sided colon cancer, left-sided colon cancer and rectal cancer reveals distinct mutational profiles.

Mol Cancer 2018 12 21;17(1):177. Epub 2018 Dec 21.

Division of Hematology/Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, 60612, USA.

Right-sided colon cancer (RCC) has worse prognosis compared to left-sided colon cancer (LCC) and rectal cancer. The reason for this difference in outcomes is not well understood. We performed comparative somatic and proteomic analyses of RCC, LCC and rectal cancers to understand the unique molecular features of each tumor sub-types. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-018-0923-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303985PMC
December 2018
11 Reads

Alteration of tumor suppressor BMP5 in sporadic colorectal cancer: a genomic and transcriptomic profiling based study.

Mol Cancer 2018 12 20;17(1):176. Epub 2018 Dec 20.

Institute of Preventive Genomic Medicine, School of Life Sciences, Northwest University, Xian, 710069, China.

Background: Although the genetic spectrum of human colorectal cancer (CRC) is mainly characterized by APC, KRAS and TP53 mutations, driver genes in tumor initiation have not been conclusively demonstrated. In this study, we aimed to identify novel markers for CRC.

Methods: We performed exome analysis of sporadic colorectal cancer (sCRC) coding regions to screen loss of function (LoF) mutation genes, and carried out systems-level approaches to confirm top rank gene in this study. Read More

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http://dx.doi.org/10.1186/s12943-018-0925-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302470PMC
December 2018
3 Reads
4.257 Impact Factor

Large-scale pharmacogenomics based drug discovery for ITGB3 dependent chemoresistance in mesenchymal lung cancer.

Mol Cancer 2018 12 18;17(1):175. Epub 2018 Dec 18.

College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.

Even when targets responsible for chemoresistance are identified, drug development is often hampered due to the poor druggability of these proteins. We systematically analyzed therapy-resistance with a large-scale cancer cell transcriptome and drug-response datasets and predicted the candidate drugs based on the gene expression profile. Our results implicated the epithelial-mesenchymal transition as a common mechanism underlying resistance to chemotherapeutic drugs. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-018-0924-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299529PMC
December 2018
2 Reads

C-Src confers resistance to mitotic stress through inhibition DMAP1/Bub3 complex formation in pancreatic cancer.

Mol Cancer 2018 12 15;17(1):174. Epub 2018 Dec 15.

The Institute of Cell Metabolism, Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200080, China.

Background: Chromatin modification at mitosis is closely related to transcriptional reactivation in the subsequent cell cycle. We reasoned this process is deregulated by oncogenic signals, which would contribute to mitotic stress resistance in pancreatic cancer. Here, we show DMAP1/Bub3 complex mediates mitotic stress-induced cellular apoptosis, while this effect is counteracted by c-Src in pancreatic cancer cells. Read More

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http://dx.doi.org/10.1186/s12943-018-0919-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295060PMC
December 2018
7 Reads
4.257 Impact Factor

LncHOXA10 drives liver TICs self-renewal and tumorigenesis via HOXA10 transcription activation.

Mol Cancer 2018 12 13;17(1):173. Epub 2018 Dec 13.

Department of Blood Transfusion, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China.

Background: Liver cancer is one of the most deadly cancers in the world. There are various cells in liver tumor bulk, including liver tumor initiating cells (TICs), which account for liver tumorigenesis, drug resistance, relapse and metastasis. The homeobox (HOX) transcription factors play critical roles in many physiological and pathological processes, while, their roles in liver TICs and liver tumorigenesis remain unknown. Read More

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http://dx.doi.org/10.1186/s12943-018-0921-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293550PMC
December 2018
13 Reads

TRIB2 functions as novel oncogene in colorectal cancer by blocking cellular senescence through AP4/p21 signaling.

Mol Cancer 2018 12 12;17(1):172. Epub 2018 Dec 12.

Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, 1095 Jiefang Av, Wuhan, Hubei, 430030, People's Republic of China.

Background: Cellular senescence is a state of irreversible cell growth arrest and senescence cells permanently lose proliferation potential. Induction of cellular senescence might be a novel therapy for cancer cells. TRIB2 has been reported to participate in regulating proliferation and drug resistance of various cancer cells. Read More

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http://dx.doi.org/10.1186/s12943-018-0922-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291992PMC
December 2018
1 Read

Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity.

Mol Cancer 2018 12 10;17(1):171. Epub 2018 Dec 10.

Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200, Copenhagen N, Denmark.

Tumorigenesis is increasingly considered to rely on subclones of cells poised to undergo an epithelial to mesenchymal transition (EMT) program. We and others have provided evidence, however, that the tumorigenesis of human breast cancer is not always restricted to typical EMT cells but is also somewhat paradoxically conveyed by subclones of apparently differentiated, non-EMT cells. Here we characterize such non-EMT-like and EMT-like subclones. Read More

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http://dx.doi.org/10.1186/s12943-018-0918-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287350PMC
December 2018
9 Reads

EphB2 stem-related and EphA2 progression-related miRNA-based networks in progressive stages of CRC evolution: clinical significance and potential miRNA drivers.

Mol Cancer 2018 11 30;17(1):169. Epub 2018 Nov 30.

Laboratory of Molecular Medicine and Biotechnology, University Campus Bio-Medico of Rome, via Alvaro del Portillo 21, 00128, Rome, Italy.

EphB2 and EphA2 control stemness and differentiation in the intestinal mucosa, but the way they cooperate with the complex mechanisms underlying tumor heterogeneity and how they affect the therapeutic outcome in colorectal cancer (CRC) patients, remain unclear. MicroRNA (miRNA) expression profiling along with pathway analysis provide comprehensive information on the dysregulation of multiple crucial pathways in CRC.Through a network-based approach founded on the characterization of progressive miRNAomes centered on EphA2/EphB2 signaling during tumor development in the AOM/DSS murine model, we found a miRNA-dependent orchestration of EphB2-specific stem-like properties in earlier phases of colorectal tumorigenesis and the EphA2-specific control of tumor progression in the latest CRC phases. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-018-0912-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271583PMC
November 2018
2 Reads

CircFAT1 sponges miR-375 to promote the expression of Yes-associated protein 1 in osteosarcoma cells.

Mol Cancer 2018 12 4;17(1):170. Epub 2018 Dec 4.

Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang Province, China.

Background: There is an urgent need to identify new molecular targets for treatment of osteosarcoma. Circular RNAs are a class of endogenous RNAs that are extensively found in mammalian cells and exert critical functions in the regulation of gene expression, but in osteosarcoma the underlying molecular mechanism of circular RNAs remain poorly understood. Here we assessed the tumorigenesis properties of a circular RNA, circFAT1 in osteosarcoma. Read More

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http://dx.doi.org/10.1186/s12943-018-0917-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280518PMC
December 2018
2 Reads

Effects of tumor metabolic microenvironment on regulatory T cells.

Mol Cancer 2018 11 26;17(1):168. Epub 2018 Nov 26.

The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.

Recent studies have shown that on one hand, tumors need to obtain a sufficient energy supply, and on the other hand they must evade the body's immune surveillance. Because of their metabolic reprogramming characteristics, tumors can modify the physicochemical properties of the microenvironment, which in turn affects the biological characteristics of the cells infiltrating them. Regulatory T cells (Tregs) are a subset of T cells that regulate immune responses in the body. Read More

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http://dx.doi.org/10.1186/s12943-018-0913-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260778PMC
November 2018
2 Reads

EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis.

Mol Cancer 2018 11 23;17(1):166. Epub 2018 Nov 23.

Institute of Traumatic Brain Injury and Neurology, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, 300162, China.

Background: Circular RNAs (circRNAs) have been found to play critical roles in the development and progression of various cancers. However, little is known about the effects of the circular RNA network on glioblastoma multiforme (GBM).

Methods: A microarray was used to screen circRNA expression in GBM. Read More

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http://dx.doi.org/10.1186/s12943-018-0911-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260852PMC
November 2018
14 Reads

CircSLC3A2 functions as an oncogenic factor in hepatocellular carcinoma by sponging miR-490-3p and regulating PPM1F expression.

Mol Cancer 2018 11 23;17(1):165. Epub 2018 Nov 23.

Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Shanghai, 200233, China.

Background: Non-coding RNAs (ncRNAs) have been reported to participate in tumor progression by regulating gene expression. Previous studies showed that protein phosphatase Mg2/Mn2 dependent 1F (PPM1F) acts a dual role in cancer growth and metastasis. But, the underlying mechanisms by which ncRNAs regulate PPM1F expression in hepatocellular carcinoma (HCC) are poorly understood. Read More

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http://dx.doi.org/10.1186/s12943-018-0909-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260990PMC
November 2018
10 Reads

The long noncoding RNA LINC00312 induces lung adenocarcinoma migration and vasculogenic mimicry through directly binding YBX1.

Mol Cancer 2018 11 23;17(1):167. Epub 2018 Nov 23.

Institute of Medical Sciences, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Xiangya Road 87th, Changsha, 410008, Hunan, People's Republic of China.

Vasculogenic mimicry (VM) gives rise to tumor neovascularization that is critical for tumor growth and metastasis. Long non-coding RNAs (lncRNAs) have been implicated in diverse and fundamental biological processes. LINC00312 is associated with lung adenocarcinoma. Read More

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http://dx.doi.org/10.1186/s12943-018-0920-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260658PMC
November 2018
8 Reads

Presence and diagnostic value of circulating tsncRNA for ovarian tumor.

Mol Cancer 2018 11 22;17(1):163. Epub 2018 Nov 22.

State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

tRNA-derived small non-coding RNAs (tsncRNAs), a class of newly defined small non-coding RNA, have been considered to be involved in various cellular biological processes through regulating gene expression at both transcriptional and post-transcriptional level. However, the presence of circulating tsncRNAs and their diagnostic potential is largely unclear. In this study, we investigate the serum-derived public transcriptome data from ovarian tumor patients and non-cancer controls, and find that circulating tsncRNAs cover a high proportion of total small RNA and are non-random degradation products in serum (ranging from 2. Read More

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http://dx.doi.org/10.1186/s12943-018-0910-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251159PMC
November 2018
1 Read

BRD4 and Cancer: going beyond transcriptional regulation.

Mol Cancer 2018 11 22;17(1):164. Epub 2018 Nov 22.

Laboratory of Translational Research, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Viale Risorgimento 80, 42123, Reggio Emilia, Italy.

BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes expression regulation. Inhibition of BRD4 shortcuts the communication between SEs and target promoters with a subsequent cell-specific repression of oncogenes to which cancer cells are addicted and cell death. To date, this is the most credited mechanism of action of BET inhibitors, a class of small molecules targeting BET proteins which are currently in clinical trials in several cancer settings. Read More

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http://dx.doi.org/10.1186/s12943-018-0915-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251205PMC
November 2018
19 Reads

LncRNA MIR31HG targets HIF1A and P21 to facilitate head and neck cancer cell proliferation and tumorigenesis by promoting cell-cycle progression.

Mol Cancer 2018 11 20;17(1):162. Epub 2018 Nov 20.

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.

LncRNAs are involved in the initiation and progression of cancer. However, the molecular mechanism and diverse clinical prognosis of MIR31HG in head and neck squamous cell carcinoma (HNSCC) are still unclear. Our previous microarray analysis showed that lncRNA MIR31HG interacted with HIF1A may play an oncogenic role in laryngeal squamous cell cancer (LSCC). Read More

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http://dx.doi.org/10.1186/s12943-018-0916-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247607PMC
November 2018
12 Reads

Invasion-related circular RNA circFNDC3B inhibits bladder cancer progression through the miR-1178-3p/G3BP2/SRC/FAK axis.

Mol Cancer 2018 11 20;17(1):161. Epub 2018 Nov 20.

Department of Urology and Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107th Yanjiangxi Road, Yuexiu District, Guangzhou, 510120, China.

Background: Increasing evidence has revealed that circular RNAs (circRNAs) play crucial roles in cancer biology. However, the role and underlying regulatory mechanisms of circFNDC3B in bladder cancer (BC) remain unknown.

Methods: A cell invasion model was established by repeated transwell assays, and invasion-related circRNAs in BC were identified through an invasion model. Read More

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http://dx.doi.org/10.1186/s12943-018-0908-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245936PMC
November 2018
9 Reads

The pro-metastasis effect of circANKS1B in breast cancer.

Mol Cancer 2018 11 19;17(1):160. Epub 2018 Nov 19.

General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, Jiangsu, China.

Background: Recent studies indicate that circular RNA (circRNA) plays a pivotal role in cancer progression. Here, we sought to investigate its role in breast cancer.

Methods: CircANKS1B (a circRNA originated from exons 5 to 8 of the ANKS1B gene, hsa_circ_0007294) was identified by RNA-sequencing and validated by qRT-PCR and Sanger sequencing. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-018-0914-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240936PMC
November 2018
10 Reads

Role of the NLRP3 inflammasome in cancer.

Mol Cancer 2018 11 17;17(1):158. Epub 2018 Nov 17.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cleaving of the pro-inflammatory cytokines interleukin (IL)-1β and proIL-18 to produce active forms. The inflammasome complex consists of a Nod-like receptor (NLR), the adapter apoptosis-associated speck-like (ASC) protein, and Caspase-1. Read More

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http://dx.doi.org/10.1186/s12943-018-0900-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240225PMC
November 2018
10 Reads

High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer.

Mol Cancer 2018 11 17;17(1):159. Epub 2018 Nov 17.

Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, 361003, Fujian Province, People's Republic of China.

Tob1, a Tob/BTG anti-proliferative protein family member, functions as a tumour suppressor in many cancers. Here, we reveal a unique oncogenic role of Tob1 in colon cancer. Tob1 expression was upregulated during colon cancer progression, was significantly correlated with tumour size and tumour differentiation, and was a prognostic indicator of colon cancer. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-018-0907-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240287PMC
November 2018
7 Reads

Sunitinib-suppressed miR-452-5p facilitates renal cancer cell invasion and metastasis through modulating SMAD4/SMAD7 signals.

Mol Cancer 2018 11 12;17(1):157. Epub 2018 Nov 12.

Department of Urology, Shanghai Tenth People's Hospital, School of Medicine in Tongji University, Shanghai, 200072, China.

Purpose: Although microRNAs (miRNAs) were revealed as crucial modulators in tumor metastasis and target therapy, our understanding of their roles in metastatic renal cell carcinoma (mRCC) and Sunitinib treatment was limited. Here we sought to identify human miRNAs that acted as key regulators in renal cancer metastasis and Sunitinib treatment.

Experimental Design: We focused on 2 published microarray data to select out our anchored miRNA and then explored the roles of miR-452-5p both in vitro and in vivo, which was downregulated after Sunitinib treatment while upregulated in metastasis renal cell carcinoma (RCC) tissues. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-018-0906-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231268PMC
November 2018
8 Reads