2,245 results match your criteria Molecular Cancer [Journal]


mA-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1.

Mol Cancer 2019 Apr 13;18(1):87. Epub 2019 Apr 13.

Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, and Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510006, China.

Background: Long noncoding RNAs (lncRNAs) have emerged as critical players in cancer progression, but their functions in colorectal cancer (CRC) metastasis have not been systematically clarified.

Methods: lncRNA expression profiles in matched normal and CRC tissue were checked using microarray analysis. The biological roles of a novel lncRNA, namely RP11-138 J23. Read More

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http://dx.doi.org/10.1186/s12943-019-1014-2DOI Listing

Myeloid-derived suppressor cells endow stem-like qualities to multiple myeloma cells by inducing piRNA-823 expression and DNMT3B activation.

Mol Cancer 2019 Apr 13;18(1):88. Epub 2019 Apr 13.

Institute of Hematology, Union Hospital,Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are two important cellular components in the tumor microenvironment, which may modify the cancer phenotype and affect patient survival. However, the crosstalk between MDSCs and multiple myeloma stem cells (MMSCs) are relatively poorly understood.

Methods: The frequencies of granulocytic-MDSCs (G-MDSCs) in MM patients were detected by flow cytometry and their association with the disease stage and patient survival were analyzed. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-019-1011-5DOI Listing
April 2019
1 Read

CD103-positive CSC exosome promotes EMT of clear cell renal cell carcinoma: role of remote MiR-19b-3p.

Mol Cancer 2019 Apr 11;18(1):86. Epub 2019 Apr 11.

Department of Urology (Heilongjiang Key Laboratory of Scientific Research in Urology), the Fourth Hospital of Harbin Medical University, No. 37 Yi-Yuan Street, Nangang District, Harbin, Heilongjiang Province, 150081, People's Republic of China.

Background: Clear cell renal cell carcinoma (CCRCC) is characterized by a highly metastatic potential. The stromal communication between stem cells and cancer cells critically influences metastatic dissemination of cancer cells.

Methods: The effect of exosomes isolated from cancer stem cells (CSCs) of CCRCC patients on the progress of epithelial-mesenchymal transition (EMT) and lung metastasis of CCRCC cells were examined. Read More

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http://dx.doi.org/10.1186/s12943-019-0997-zDOI Listing
April 2019
1 Read

Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy.

Mol Cancer 2019 Apr 10;18(1):85. Epub 2019 Apr 10.

Division of Cancer Biology, Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, GA, 30322, USA.

Background: Lung cancer patients with KRAS mutation(s) have a poor prognosis due in part to the development of resistance to currently available therapeutic interventions. Development of a new class of anticancer agents that directly targets KRAS may provide a more attractive option for the treatment of KRAS-mutant lung cancer.

Results: Here we identified a small molecule KRAS agonist, KRA-533, that binds the GTP/GDP-binding pocket of KRAS. Read More

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http://dx.doi.org/10.1186/s12943-019-1012-4DOI Listing
April 2019
1 Read

Novel lncRNA-IUR suppresses Bcr-Abl-induced tumorigenesis through regulation of STAT5-CD71 pathway.

Mol Cancer 2019 Apr 8;18(1):84. Epub 2019 Apr 8.

Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.

Background: Long noncoding RNAs (lncRNAs), defined as the transcripts longer than 200 nt without protein-coding capacity, have been found to be aberrantly expressed in diverse human diseases including cancer. A reciprocal translocation between chromosome 9 and 22 generates the chimeric Bcr-Abl oncogene, which is associated with several hematological malignancies. However, the functional relevance between aberrantly expressed lncRNAs and Bcr-Abl-mediated leukemia remains obscure. Read More

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http://dx.doi.org/10.1186/s12943-019-1013-3DOI Listing
April 2019
1 Read

The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers.

Mol Cancer 2019 Apr 6;18(1):83. Epub 2019 Apr 6.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management & West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, Sichuan, China.

The proliferation and metastasis ability of tumors are mediate by the "mutual dialogue" between cells in the tumor microenvironment (TME). Extracellular vesicles (EVs), mainly exosomes and microvesicles, play an important role in achieving intercellular substance transport and information transfer in the TME. Initially considered "garbage dumpsters" and later referred to as "signal boxes", EVs carry "cargo" (proteins, lipids, or nucleic acids) that can redirect the function of a recipient cell. Read More

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http://dx.doi.org/10.1186/s12943-019-0985-3DOI Listing

A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma.

Mol Cancer 2019 04 5;18(1):81. Epub 2019 Apr 5.

Department of Urology, Renji Hospital, School of Medicine in Shanghai Jiao Tong University, 160 Pujian Road, Pudong District, Shanghai, 200127, China.

Background: The aberrant expression of long noncoding RNAs (lncRNAs) has recently emerged as key molecules in human cancers; however, whether lncRNAs are implicated in the progression of clear cell renal cell carcinoma (ccRCC) remains unclear.

Methods: Candidate lncRNAs were selected using microarray analysis and quantitative real-time PCR (qRT-PCR) was performed to detect lncRNAs expression in human ccRCC tissues. Overexpression and knocking down experiments in vivo and in vitro were performed to uncover the biological roles of lncRNA-URRCC on ccRCC cell proliferation and invasion. Read More

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http://dx.doi.org/10.1186/s12943-019-0998-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449923PMC
April 2019
1 Read

CircDLST promotes the tumorigenesis and metastasis of gastric cancer by sponging miR-502-5p and activating the NRAS/MEK1/ERK1/2 signaling.

Mol Cancer 2019 04 5;18(1):80. Epub 2019 Apr 5.

Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Shanghai, 200233, China.

Background: Accumulating evidence shows that, the dysregulation of circular RNAs (circRNAs) is associated with the progression of multiple malignancies. But, the underlying mechanisms by which has_circ_0032627 (circDLST) contributed to gastric cancer (GC) remain undocumented.

Methods: The expression and cellular localization of circDLST and its association with clinicopathological characteristics and prognosis in patients with GC was analysed by using fluorescence in situ hybridization. Read More

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http://dx.doi.org/10.1186/s12943-019-1015-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449953PMC
April 2019
4 Reads

Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy.

Mol Cancer 2019 Apr 5;18(1):82. Epub 2019 Apr 5.

Department of General Surgery, XinHua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200092, China.

Background: Gallbladder cancer is the most common biliary tract malignancy and not sensitive to chemotherapy. Autophagy is an important factor prolonging the survival of cancer cells under chemotherapeutic stress. We aimed to investigate the role of long non-coding RNAs (lncRNAs) in autophagy and chemoresistance of gallbladder cancer cells. Read More

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http://dx.doi.org/10.1186/s12943-019-1016-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449938PMC
April 2019
3 Reads

Correction to: Role of Bruton's tyrosine kinase in B cells and malignancies.

Mol Cancer 2019 04 3;18(1):79. Epub 2019 Apr 3.

Department of Pulmonary Medicine, Room Ee2251a, Erasmus MC Rotterdam, PO Box 2040, NL 3000, CA, Rotterdam, The Netherlands.

Following publication of the original article [1], the authors reported an error in Table 1. Read More

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http://dx.doi.org/10.1186/s12943-019-1009-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446284PMC

Neddylation: a novel modulator of the tumor microenvironment.

Mol Cancer 2019 04 3;18(1):77. Epub 2019 Apr 3.

Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

Neddylation, a post-translational modification that adds an ubiquitin-like protein NEDD8 to substrate proteins, modulates many important biological processes, including tumorigenesis. The process of protein neddylation is overactivated in multiple human cancers, providing a sound rationale for its targeting as an attractive anticancer therapeutic strategy, as evidence by the development of NEDD8-activating enzyme (NAE) inhibitor MLN4924 (also known as pevonedistat). Neddylation inhibition by MLN4924 exerts significantly anticancer effects mainly by triggering cell apoptosis, senescence and autophagy. Read More

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http://dx.doi.org/10.1186/s12943-019-0979-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446326PMC

Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma.

Mol Cancer 2019 04 3;18(1):78. Epub 2019 Apr 3.

Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China.

Background: Emerging evidence indicates that tumor cells release a large amount of exosomes loaded with cargos during tumorigenesis. Exosome secretion is a multi-step process regulated by certain related molecules. Long non-coding RNAs (lncRNAs) play an important role in hepatocellular carcinoma (HCC) progression. Read More

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http://dx.doi.org/10.1186/s12943-019-0990-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446409PMC
April 2019
2 Reads

Correction to: Proteogenomic characterization and comprehensive integrative genomic analysis of human colorectal cancer liver metastasis.

Mol Cancer 2019 04 2;18(1):72. Epub 2019 Apr 2.

Central Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Middle 301 Yanchang Road, Shanghai, 200072, China.

Following publication of the original article [1], the authors reported an error in affiliation 5. Read More

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http://dx.doi.org/10.1186/s12943-019-1005-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444859PMC

Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression.

Mol Cancer 2019 04 2;18(1):73. Epub 2019 Apr 2.

Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang Province, China.

Background: As a subclass of noncoding RNAs, circular RNAs (circRNAs) have been demonstrated to play a critical role in regulating gene expression in eukaryotes. Recent studies have revealed the pivotal functions of circRNAs in cancer progression. However, little is known about the role of circTADA2A, also named hsa_circ_0043278, in osteosarcoma (OS). Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-019-1007-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444890PMC
April 2019
1 Read

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance.

Mol Cancer 2019 04 2;18(1):75. Epub 2019 Apr 2.

Department of Biochemistry and Molecular Biology, LSUHSC School of Medicine, New Orleans, USA.

Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion, metastasis and drug-resistance. Exosomes initiate or suppress various signaling pathways in the recipient cells via transmitting heterogeneous cargoes. In this review we discuss exosome biogenesis, exosome mediated metastasis and chemoresistance. Read More

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http://dx.doi.org/10.1186/s12943-019-0991-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444571PMC
April 2019
2 Reads

Exosomal tRNA-derived small RNA as a promising biomarker for cancer diagnosis.

Mol Cancer 2019 04 2;18(1):74. Epub 2019 Apr 2.

State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.

tRNA-derived small RNA (tsRNA) is a novel regulatory small non-coding RNA and participates in diverse physiological and pathological processes. However, the presence of tsRNAs in exosome and their diagnostic potential remain unclear. In this study, we took advantage of small RNA-seq technology to profile exosomal tsRNAs from cell culture medium and plasma, and found ubiquitous presence of tsRNAs in exosome. Read More

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http://dx.doi.org/10.1186/s12943-019-1000-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444574PMC

Exosomal let-7d-3p and miR-30d-5p as diagnostic biomarkers for non-invasive screening of cervical cancer and its precursors.

Mol Cancer 2019 04 2;18(1):76. Epub 2019 Apr 2.

Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Women's Reproductive Health Key Laboratory of Zhejiang Province, Department of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Cervical cancer screening through detection and treatment of high-grade cervical intraepithelial neoplasia (CIN) is most successful in cancer prevention. However, the accuracy of the current cervical cancer screening tests is still low. The aim of this study was to develop a more accurate method based on circulating exosomal miRNAs. Read More

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http://dx.doi.org/10.1186/s12943-019-0999-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446401PMC
April 2019
2 Reads
4.257 Impact Factor

Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer.

Mol Cancer 2019 03 30;18(1):67. Epub 2019 Mar 30.

Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Dúbravská cesta 9, 845 05, Bratislava, Slovakia.

Although solid tumors comprise malignant cells, they also contain many different non-malignant cell types in their micro-environment. The cellular components of the tumor stroma consist of immune and endothelial cells combined with a heterogeneous population of stromal cells which include cancer-associated fibroblasts. The bi-directional interactions between tumor and stromal cells therefore substantially affect tumor cell biology. Read More

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http://dx.doi.org/10.1186/s12943-019-0960-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441200PMC

Tumor microenvironment-driven non-cell-autonomous resistance to antineoplastic treatment.

Mol Cancer 2019 03 30;18(1):69. Epub 2019 Mar 30.

School of Life Sciences, Jilin University, Changchun, 130012, China.

Drug resistance is of great concern in cancer treatment because most effective drugs are limited by the development of resistance following some periods of therapeutic administration. The tumor microenvironment (TME), which includes various types of cells and extracellular components, mediates tumor progression and affects treatment efficacy. TME-mediated drug resistance is associated with tumor cells and their pericellular matrix. Read More

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http://dx.doi.org/10.1186/s12943-019-0992-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441162PMC
March 2019
1 Read

Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis.

Mol Cancer 2019 03 30;18(1):64. Epub 2019 Mar 30.

Department of Gastrointestinal Surgery & Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: Tumor-associated macrophages (TAMs) are major components of tumor microenvironment that frequently associated with tumor metastasis in human cancers. Circulating tumor cell (CTC), originating from primary tumor sites, is considered to be the precursors of tumor metastasis. However, the regulatory mechanism of TAMs in CTC-mediated tumor metastasis still remains unclear. Read More

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http://dx.doi.org/10.1186/s12943-019-0976-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441214PMC
March 2019
1 Read

Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression.

Mol Cancer 2019 03 30;18(1):71. Epub 2019 Mar 30.

Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu province, China.

Background: Cisplatin (CDDP) treatment is one of the most predominant chemotherapeutic strategies for patients with gastric cancer (GC). A better understanding of the mechanisms of CDDP resistance can greatly improve therapeutic efficacy in patients with GC. Circular RNAs (circRNAs) are a class of noncoding RNAs whose functions are related to the pathogenesis of cancer, but, in CDDP resistance of GC remains unknown. Read More

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http://dx.doi.org/10.1186/s12943-019-0969-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441201PMC
March 2019
1 Read

Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review.

Mol Cancer 2019 03 30;18(1):63. Epub 2019 Mar 30.

Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, CZ-625 00, Brno, Czech Republic.

The tumor microenvironment (TME) is comprised of many different cell populations, such as cancer-associated fibroblasts and various infiltrating immune cells, and non-cell components of extracellular matrix. These crucial parts of the surrounding stroma can function as both positive and negative regulators of all hallmarks of cancer development, including evasion of apoptosis, induction of angiogenesis, deregulation of the energy metabolism, resistance to the immune detection and destruction, and activation of invasion and metastasis. This review represents a summary of recent studies focusing on describing these effects of microenvironment on initiation and progression of the head and neck squamous cell carcinoma, focusing on oral squamous cell carcinoma, since it is becoming clear that an investigation of differences in stromal composition of the head and neck squamous cell carcinoma microenvironment and their impact on cancer development and progression may help better understand the mechanisms behind different responses to therapy and help define possible targets for clinical intervention. Read More

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http://dx.doi.org/10.1186/s12943-019-0983-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441173PMC

Reactive oxygen species: a volatile driver of field cancerization and metastasis.

Mol Cancer 2019 03 30;18(1):65. Epub 2019 Mar 30.

School of Biological Sciences, Nanyang Technological University Singapore, 60 Nanyang Drive, Singapore, 637551, Singapore.

Field cancerization and metastasis are the leading causes for cancer recurrence and mortality in cancer patients. The formation of primary, secondary tumors or metastasis is greatly influenced by multifaceted tumor-stroma interactions, in which stromal components of the tumor microenvironment (TME) can affect the behavior of the cancer cells. Many studies have identified cytokines and growth factors as cell signaling molecules that aid cell to cell communication. Read More

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http://dx.doi.org/10.1186/s12943-019-0961-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441160PMC

Stem cells in homeostasis and cancer of the gut.

Mol Cancer 2019 03 30;18(1):66. Epub 2019 Mar 30.

Amsterdam UMC, University of Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology and Metabolism, Meibergdreef 9, 1105, Amsterdam, AZ, Netherlands.

The intestinal epithelial lining is one of the most rapidly renewing cell populations in the body. As a result, the gut has been an attractive model to resolve key mechanisms in epithelial homeostasis. In particular the role of intestinal stem cells (ISCs) in the renewal process has been intensely studied. Read More

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http://dx.doi.org/10.1186/s12943-019-0962-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441158PMC

Targeting interleukin-6 as a strategy to overcome stroma-induced resistance to chemotherapy in gastric cancer.

Mol Cancer 2019 03 30;18(1):68. Epub 2019 Mar 30.

Department of Surgery, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon-si, 16499, Gyeonggi-do, Republic of Korea.

Background: Although the tumor stroma in solid tumors like gastric cancer (GC) plays a crucial role in chemo-resistance, specific targets to inhibit the interaction between the stromal and cancer cells have not yet been utilized in clinical practice. The present study aims to determine whether cancer-associated fibroblasts (CAFs), a major component of the tumor stroma, confer chemotherapeutic resistance to GC cells, and to discover potential targets to improve chemo-response in GC.

Methods: To identify CAF-specific proteins and signal transduction pathways affecting chemo-resistance in GC cells, secretome and transcriptome analyses were performed. Read More

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http://dx.doi.org/10.1186/s12943-019-0972-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441211PMC
March 2019
4.257 Impact Factor

Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance.

Mol Cancer 2019 03 30;18(1):70. Epub 2019 Mar 30.

Istituto di Patologia Generale, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy.

In the last decades, the role of the microenvironment in tumor progression and therapeutic outcome has gained increasing attention. Cancer-associated fibroblasts (CAFs) have emerged as key players among stromal cells, owing to their abundance in most solid tumors and their diverse tumor-restraining/promoting roles. The interplay between tumor cells and neighboring CAFs takes place by both paracrine signals (cytokines, exosomes and metabolites) or by the multifaceted functions of the surrounding extracellular matrix. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-019-0994-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441236PMC
March 2019
1 Read

Exosome-orchestrated hypoxic tumor microenvironment.

Mol Cancer 2019 03 30;18(1):57. Epub 2019 Mar 30.

Department of Head and Neck Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, No. 55, Section 4, Renmin South Road, 610041, Chengdu, Sichuan, People's Republic of China.

Hypoxic tumor microenvironment is a common feature of solid tumors and is associated with aggressiveness and poor patient outcomes. A continuous interference between cancer cells and stromal cells within the hypoxic microenvironment has been uncovered for its importance in cancer development and treatment responsiveness. Exosomes, initially considered as "garbage bins" for unwanted material from cells, are now elucidated to perform a variety of functions that involve interactions within the cellular microenvironment due to their ability to carry numerous cargoes, including lipids, proteins, nucleic acids, and metabolites. Read More

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http://dx.doi.org/10.1186/s12943-019-0982-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441221PMC

Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression.

Mol Cancer 2019 03 30;18(1):50. Epub 2019 Mar 30.

Cancer institute, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.

Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) are heterogenous vesicles formed by budding of the cellular membrane, which are secreted in larger amounts by cancer cells than normal cells. Recently, several reports have also disclosed that MVs function as important mediators of intercellular communication between cancerous and stromal cells within the TME, orchestrating complex pathophysiological processes. Read More

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http://dx.doi.org/10.1186/s12943-019-0973-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441155PMC

The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy.

Mol Cancer 2019 03 30;18(1):62. Epub 2019 Mar 30.

Department of Clinical Laboratory Medicine, Shenzhen Hospital, Southern Medical University, No. 1333, Xinhu Road, Baoan District, Shenzhen, 518020, Guangdong, People's Republic of China.

Gastric cancer (GC) is one of the leading causes of cancer-related death in both men and women due to delayed diagnosis and high metastatic frequency. Extracellular vesicles (EVs) are membrane-bound nanovesicles which are released by cells into body fluids such as plasma, saliva, breast milk, cerebrospinal fluid, semen, urine, lymphatic fluid, amniotic fluid, sputum and synovial fluid. EVs deliver almost all types of biomolecules such as proteins, nucleic acids, metabolites, and even pharmacological compounds. Read More

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http://dx.doi.org/10.1186/s12943-019-0967-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441168PMC
March 2019
1 Read

MiR155 sensitized B-lymphoma cells to anti-PD-L1 antibody via PD-1/PD-L1-mediated lymphoma cell interaction with CD8+T cells.

Mol Cancer 2019 03 30;18(1):54. Epub 2019 Mar 30.

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Shanghai Rui Jin Hospital, 197 Rui Jin Er Road, Shanghai, 200025, China.

Background: MicroRNAs (miRs) are involved in lymphoma progression by regulating tumor cell interaction with microenvironment. MiR155 is overexpressed in diffuse large B-cell lymphoma (DLBCL) and its biological effect on tumor microenvironment needs to be futher investigated.

Methods: MiR155 was detected by quantitative real-time PCR in patients with newly diagnosed DLBCL. Read More

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http://dx.doi.org/10.1186/s12943-019-0977-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441197PMC
March 2019
5 Reads
4.257 Impact Factor

Extracellular vesicles in the tumor microenvironment: old stories, but new tales.

Mol Cancer 2019 03 30;18(1):59. Epub 2019 Mar 30.

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.

Mammalian cells synthesize and release heterogeneous extracellular vesicles (EVs) which can be generally recognized as subclasses including exosomes, microvesicles (MVs), and apoptotic bodies (ABs), each differing in their biogenesis, composition and biological functions from others. EVs can originate from normal or cancer cells, transfer bioactive cargoes to both adjacent and distant sites, and orchestrate multiple key pathophysiological events such as carcinogenesis and malignant progression. Emerging as key messengers that mediate intercellular communications, EVs are being paid substantial attention in various disciplines including but not limited to cancer biology and immunology. Read More

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http://dx.doi.org/10.1186/s12943-019-0980-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441234PMC

Long noncoding RNA Pvt1 regulates the immunosuppression activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice.

Mol Cancer 2019 03 30;18(1):61. Epub 2019 Mar 30.

Department of Laboratory Medicine, the Affiliated People's Hospital, Jiangsu University, Zhenjiang, 212013, China.

Background: Myeloid-derived suppressor cells (MDSCs) participate in tumor-elicited immunosuppression by dramatically blocking T-cell-induced antitumor responses, thereby influencing the effectiveness of cancer immunotherapies. Treatments that alter the differentiation and function of MDSCs can partially restore antitumor immune responses. The long noncoding RNA plasmacytoma variant translocation 1 (lncRNA Pvt1) is a potential oncogene in a variety of cancer types. Read More

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http://dx.doi.org/10.1186/s12943-019-0978-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441229PMC
March 2019
1 Read

Emerging roles and therapeutic value of exosomes in cancer metastasis.

Mol Cancer 2019 03 30;18(1):53. Epub 2019 Mar 30.

Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, Ministry of Education), Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, People's Republic of China.

Exosomes are cell-derived vesicles of 30 to 150 nm that contain diverse proteins, nucleic acids, and lipids. These vesicles facilitate effective intercellular communication and trigger profound environmental changes. In recent years, many studies have identified diverse roles for exosomes in tumor metastasis, a major cause of cancer-related deaths; furthermore, circulating tumor-derived exosomes can drive the initiation and progression of metastasis and determine the specific target organs affected. Read More

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http://dx.doi.org/10.1186/s12943-019-0964-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441156PMC

TAMing pancreatic cancer: combat with a double edged sword.

Mol Cancer 2019 03 30;18(1):48. Epub 2019 Mar 30.

Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala State, 695014, India.

Among all the deadly cancers, pancreatic cancer ranks seventh in mortality. The absence of any grave symptoms coupled with the unavailability of early prognostic and diagnostic markers make the disease incurable in most of the cases. This leads to a late diagnosis, where the disease would have aggravated and thus, incurable. Read More

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http://dx.doi.org/10.1186/s12943-019-0966-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441154PMC

Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance.

Mol Cancer 2019 03 30;18(1):55. Epub 2019 Mar 30.

Division of Translational Medicine, Sidra Medicine, PO BOX 26999, Doha, Qatar.

The tumor microenvironment represents a complex network, in which tumor cells not only communicate with each other but also with stromal and immune cells. Current research has demonstrated the vital role of the tumor microenvironment in supporting tumor phenotype via a sophisticated system of intercellular communication through direct cell-to-cell contact or by classical paracrine signaling loops of cytokines or growth factors. Recently, extracellular vesicles have emerged as an important mechanism of cellular interchange of bioactive molecules. Read More

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http://dx.doi.org/10.1186/s12943-019-0965-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441157PMC
March 2019
4.257 Impact Factor

Therapy resistance mediated by exosomes.

Mol Cancer 2019 03 30;18(1):58. Epub 2019 Mar 30.

Laboratory for Experimental and Translational Research on Radiation Oncology (EXTRO-Lab), Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, Anichstr. 35, A-6020, Innsbruck, Austria.

Therapy resistance can arise within tumor cells because of genetic or phenotypic changes (intrinsic resistance), or it can be the result of an interaction with the tumor microenvironment (extrinsic resistance). Exosomes are membranous vesicles 40 to 100 nm in diameter constitutively released by almost all cell types, and mediate cell-to-cell communication by transferring mRNAs, miRNAs, DNAs and proteins causing extrinsic therapy resistance. They transfer therapy resistance by anti-apoptotic signalling, increased DNA-repair or delivering ABC transporters to drug sensitive cells. Read More

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http://dx.doi.org/10.1186/s12943-019-0970-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441190PMC

mRNA-to-protein translation in hypoxia.

Mol Cancer 2019 03 30;18(1):49. Epub 2019 Mar 30.

Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami, FL, 33136, USA.

Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays an important role in generating ATP to maintain a productive rate of protein synthesis in normoxia. In hypoxia, the rate of the canonical protein synthesis pathway is significantly slowed and impaired due to limited ATP availability, necessitating an alternative mechanism to mediate protein synthesis and facilitate adaptation. Read More

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http://dx.doi.org/10.1186/s12943-019-0968-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441220PMC

Synergistic effect of immune checkpoint blockade and anti-angiogenesis in cancer treatment.

Mol Cancer 2019 03 30;18(1):60. Epub 2019 Mar 30.

Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Immune checkpoint inhibitor (ICI) activates host's anti-tumor immune response by blocking negative regulatory immune signals. A series of clinical trials showed that ICI could effectively induce tumor regression in a subset of advanced cancer patients. In clinical practice, a main concerning for choosing ICI is the low response rate. Read More

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http://dx.doi.org/10.1186/s12943-019-0974-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441150PMC

Exploiting vulnerabilities of cancer by targeting nuclear receptors of stromal cells in tumor microenvironment.

Mol Cancer 2019 03 30;18(1):51. Epub 2019 Mar 30.

School of Biological Sciences, Nanyang Technological University Singapore, 60 Nanyang Drive, Singapore, 637551, Singapore.

The tumor microenvironment is a complex and dynamic cellular community comprising the tumor epithelium and various tumor-supporting cells such as immune cells, fibroblasts, immunosuppressive cells, adipose cells, endothelial cells, and pericytes. The interplay between the tumor microenvironment and tumor cells represents a key contributor to immune evasiveness, physiological hardiness and the local and systemic invasiveness of malignant cells. Nuclear receptors are master regulators of physiological processes and are known to play pro-/anti-oncogenic activities in tumor cells. Read More

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http://dx.doi.org/10.1186/s12943-019-0971-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441226PMC

Mechanisms associated with biogenesis of exosomes in cancer.

Mol Cancer 2019 03 30;18(1):52. Epub 2019 Mar 30.

Department of Cancer Biology, Metastasis Research Center, University of Texas, MD Anderson Cancer Center, Unit 1906, 1881 East Road, Houston, TX, 77054, USA.

Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer. Exosomes have emerged as potential regulators of intracellular communication in cancer. Exosomes are nanovesicles released by cells that contain biomolecules and are exchanged between cells. Read More

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http://dx.doi.org/10.1186/s12943-019-0963-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441149PMC

A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling.

Mol Cancer 2019 03 29;18(1):47. Epub 2019 Mar 29.

Department of Tumor Biological Treatment, the Third Affiliated Hospital of Soochow University, Changzhou, 213003, People's Republic of China.

Background: It has been well established that circular RNAs (circRNAs) play an important regulatory role during tumor progression. Recent studies have indicated that even though circRNAs generally regulate gene expression through miRNA sponges, they may encode small peptides in tumor pathogenesis. However, it remains largely unexplored whether circRNAs are involved in the tumorigenesis of colon cancer (CC). Read More

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http://dx.doi.org/10.1186/s12943-019-1010-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440158PMC

Exo-circRNAs: a new paradigm for anticancer therapy.

Mol Cancer 2019 03 30;18(1):56. Epub 2019 Mar 30.

National Clinical Research Center for Geriatrics and State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.

CircRNAs, as new members of long noncoding RNAs, have been the focus of recent investigation. CircRNAs feature a closed continuous loop structure without 5'-3' polarity or a poly A tail. Many studies have reported the potential application of circRNAs in the clinic as new biomarkers and therapeutic targets in different diseases, especially for cancer. Read More

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http://dx.doi.org/10.1186/s12943-019-0986-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441195PMC

Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation of transcription factor SOX4.

Mol Cancer 2019 03 28;18(1):45. Epub 2019 Mar 28.

Department of General Surgery, the Fourth Affiliated Hospital of Harbin Medical University, No. 37 Yiyuan Street, Nangang District, Harbin, 150001, People's Republic of China.

Background: Circular RNAs (circRNAs) are a novel type of noncoding RNAs and play important roles in tumorigenesis, including gastric cancer (GC). However, the functions of most circRNAs remain poorly understood. In our study, we aimed to investigate the functions of a new circRNA circ-DONSON in GC progression. Read More

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http://dx.doi.org/10.1186/s12943-019-1006-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437893PMC
March 2019
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RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3.

Mol Cancer 2019 03 28;18(1):46. Epub 2019 Mar 28.

School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.

Background: N6-methyladenosine (m6A) modification is the most pervasive modification in mRNA, and has been considered as a new layer of epigenetic regulation on mRNA processing, stability and translation. Despite its functional significance in various physiological processes, the role of the m6A modification involved in breast cancer is yet fully understood.

Methods: We used the m6A-RNA immunoprecipitation sequencing to identify the potential targets in breast cancer. Read More

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http://dx.doi.org/10.1186/s12943-019-1004-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437932PMC

Circular RNAs and their roles in head and neck cancers.

Mol Cancer 2019 03 21;18(1):44. Epub 2019 Mar 21.

Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye & ENT Hospital of Fudan University, Shanghai, People's Republic of China.

Circular RNAs are abundant endogenous non-coding RNA with no 5' cap and 3' polyadenylation tail that modify liner mRNAs and have no terminal structures. Our knowledge of the biogenesis of circular RNAs has been expanded, and circular RNAs were shown to be key regulators of various diseases, especially cancers. Head and neck cancers are the sixth most popular cancers worldwide, and the overall survival rates remain unsatisfactory. Read More

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http://dx.doi.org/10.1186/s12943-019-1003-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427840PMC
March 2019
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Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer.

Mol Cancer 2019 03 19;18(1):43. Epub 2019 Mar 19.

Department of Clinical Laboratory, The Second Hospital of Shandong University, No. 247 Beiyuan Street, Jinan, 250033, China.

Background: Oxaliplatin resistance is a major challenge for treatment of advanced colorectal cancer (CRC). Both acquisition of epithelial-mesenchymal transition (EMT) and suppressed drug accumulation in cancer cells contributes to development of oxaliplatin resistance. Aberrant expression of small noncoding RNA, miR-128-3p, has been shown to be a key regulator in tumorigenesis and cancer development. Read More

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http://dx.doi.org/10.1186/s12943-019-0981-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423768PMC
March 2019
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MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer.

Mol Cancer 2019 03 18;18(1):42. Epub 2019 Mar 18.

Institute of Molecular and Genomic Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County, 35053, Taiwan.

Background: Triple-negative breast cancer (TNBC) is a poor prognostic breast cancer with the highest mutations and limited therapeutic choices. Cytokine networking between cancer cells and the tumor microenvironment (TME) maintains the self-renewing subpopulation of breast cancer stem cells (BCSCs) that mediate tumor heterogeneity, resistance and recurrence. Immunotherapy of those factors combined with targeted therapy or chemoagents may advantage TNBC treatment. Read More

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http://dx.doi.org/10.1186/s12943-019-0988-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421700PMC
March 2019
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Exosomes in gastric cancer: roles, mechanisms, and applications.

Mol Cancer 2019 03 15;18(1):41. Epub 2019 Mar 15.

Institute of Digestive Diseases, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, 212002, Jiangsu, China.

Exosomes are nanosized extracellular vesicles that can be released by almost all types of cells. Initially considered as the garbage bins acting to discard unwanted products of cells, exosomes are now recognized as an important way for cellular communication by transmitting bioactive molecules including proteins, DNA, mRNAs, and non-coding RNAs. The recent studies have shown that exosomes are critically involved in human health and diseases including cancer. Read More

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http://dx.doi.org/10.1186/s12943-019-1001-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419325PMC

Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT.

Mol Cancer 2019 03 13;18(1):40. Epub 2019 Mar 13.

Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.

Background: Metastasis is the main cause of lung cancer mortality. Bone marrow-derived mesenchymal stem cells (BMSCs) are a component of the cancer microenvironment and contribute to cancer progression. Intratumoral hypoxia affects both cancer and stromal cells. Read More

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http://dx.doi.org/10.1186/s12943-019-0959-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417285PMC
March 2019
1 Read

Effects of exosomes on pre-metastatic niche formation in tumors.

Mol Cancer 2019 03 11;18(1):39. Epub 2019 Mar 11.

Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

A pre-metastatic niche is a microenvironment prepared for the colonization of circulating tumor cells in specific organs. Exosomes are extracellular vesicles with a variety of biological functions. Exosomes play an irreplaceable role in the development of pre-metastatic niches, and mainly function as communication medium. Read More

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-019-0995-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413442PMC
March 2019
7 Reads