679 results match your criteria Molecular Brain [Journal]


DA-JC1 improves learning and memory by antagonizing Aβ31-35-induced circadian rhythm disorder.

Mol Brain 2019 02 11;12(1):14. Epub 2019 Feb 11.

Department of Pathology, Shanxi Medical University, Taiyuan, People's Republic of China.

Studies have shown that a normal circadian rhythm is crucial to learning and memory. Circadian rhythm disturbances that occur at early stages of Alzheimer's disease (AD) aggravate the progression of the disease and further reduce learning and memory in AD patients. The novel, dual GLP-1R/GIPR agonist DA-JC1 has been found to exert a stronger hypoglycemic effect than a GLP-1R agonist alone and has been shown to exert neuroprotective effects. Read More

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http://dx.doi.org/10.1186/s13041-019-0432-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371467PMC
February 2019

Determination of circuit-specific morphological adaptations in ventral tegmental area dopamine neurons by chronic morphine.

Mol Brain 2019 02 8;12(1):10. Epub 2019 Feb 8.

Neuroscience Program and Department of Physiology, Michigan State University, 567 Wilson Road, BPS 3182, East Lansing, MI, 48824, USA.

Chronic opiate exposure induces neuroadaptations in the mesocorticolimbic system including ventral tegmental area (VTA) dopamine (DA) neurons, whose soma size is decreased following opiate exposure. Yet it is now well documented that VTA DA neurons are heterogeneous, with notable differences between VTA DA neurons based on their projection target. Therefore, we sought to determine whether chronic morphine induced similar changes in the morphology of VTA DA neurons that project to the nucleus accumbens (NAc) and prefrontal cortex (PFC). Read More

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http://dx.doi.org/10.1186/s13041-019-0435-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368752PMC
February 2019

Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC.

Mol Brain 2019 02 8;12(1):12. Epub 2019 Feb 8.

Molecular Neuroscience, Department of Physiology and Pharmacology, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, T2N 4N1, Canada.

This study describes the functional interaction between Cav3.2 calcium channels and the Epithelial Sodium Channel (ENaC). β-ENaC subunits showed overlapping expression with endogenous Cav3. Read More

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https://molecularbrain.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13041-019-0433-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368719PMC
February 2019
5 Reads

Baicalin regulates the dopamine system to control the core symptoms of ADHD.

Mol Brain 2019 02 8;12(1):11. Epub 2019 Feb 8.

Nanjing University of Chinese Medicine, Xianlin road no.138, Qixia District, Nanjing City, Jiangsu Province, 210023, China.

We aimed to test the therapeutic effects of baicalin on attention deficit hyperactivity disorder (ADHD) in an animal model and to explain the potential mechanism. We investigated the therapeutic effects and mechanisms of baicalin in a spontaneously hypertensive rat (SHR) model of ADHD depending on the dopamine (DA) deficit theory. In this study, fifty SHRs were randomly divided into five groups: methylphenidate (MPH), baicalin (50 mg/kg, 100 mg/kg, or 150 mg/kg), and saline-treated. Read More

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http://dx.doi.org/10.1186/s13041-019-0428-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368814PMC
February 2019
2 Reads

Motor skills mediated through cerebellothalamic tracts projecting to the central lateral nucleus.

Mol Brain 2019 02 8;12(1):13. Epub 2019 Feb 8.

Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University, Fukushima, 960-1295, Japan.

The cerebellum regulates complex animal behaviors, such as motor control and spatial recognition, through communication with many other brain regions. The major targets of the cerebellar projections are the thalamic regions including the ventroanterior nucleus (VA) and ventrolateral nucleus (VL). Another thalamic target is the central lateral nucleus (CL), which receives the innervations mainly from the dentate nucleus (DN) in the cerebellum. Read More

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http://dx.doi.org/10.1186/s13041-019-0431-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368787PMC
February 2019
1 Read

Correction to: The effect of Neuroligin-2 absence on sleep architecture and electroencephalographic activity in mice.

Mol Brain 2019 01 30;12(1). Epub 2019 Jan 30.

Research Center and Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal (CIUSSS-NIM), 5400 Gouin West blvd, Montréal, QC H4J 1C5, Canada.

Correction to: Molecular Brain (2018) 11:52 https://doi.org/10.1186/s13041-018-0394-3Following publication of the original article [1], the authors reported that the article was mistakenly submitted with the omission of two authors: Feng Cao and Zhengping Jia. Read More

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http://dx.doi.org/10.1186/s13041-019-0425-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352436PMC
January 2019

Genetic risk variants for brain disorders are enriched in cortical H3K27ac domains.

Mol Brain 2019 01 28;12(1). Epub 2019 Jan 28.

University of Exeter Medical School, RILD Building, Royal Devon & Exeter Hospital, University of Exeter, Barrack Rd, Exeter, EX2 5DW, UK.

Most variants associated with complex phenotypes in genome-wide association studies (GWAS) do not directly index coding changes affecting protein structure. Instead they are hypothesized to influence gene regulation, with common variants associated with disease being enriched in regulatory domains including enhancers and regions of open chromatin. There is interest, therefore, in using epigenomic annotation data to identify the specific regulatory mechanisms involved and prioritize risk variants. Read More

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https://molecularbrain.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13041-019-0429-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348673PMC
January 2019
4 Reads

Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer's disease.

Mol Brain 2019 01 28;12(1). Epub 2019 Jan 28.

School of Biological Sciences, Division of Structural Biology and Biochemistry, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore.

Mitochondrial dysfunction is a key feature in both aging and neurodegenerative diseases including Alzheimer's disease (AD), but the molecular signature that distinguishes pathological changes in the AD from healthy aging in the brain mitochondria remain poorly understood. In order to unveil AD specific mitochondrial dysfunctions, this study adopted a discovery-driven approach with isobaric tag for relative and absolute quantitation (iTRAQ) and label-free quantitative proteomics, and profiled the mitochondrial proteomes in human brain tissues of healthy and AD individuals. LC-MS/MS-based iTRAQ quantitative proteomics approach revealed differentially altered mitochondriomes that distinguished the AD's pathophysiology-induced from aging-associated changes. Read More

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http://dx.doi.org/10.1186/s13041-019-0430-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350377PMC
January 2019

Hyperexcitability of the local cortical circuit in mouse models of tuberous sclerosis complex.

Mol Brain 2019 01 25;12(1). Epub 2019 Jan 25.

Department of Anatomy & Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.

Tuberous sclerosis complex (TSC) is a neurogenetic disorder associated with epilepsy, intellectual disabilities, and autistic behaviors. These neurological symptoms result from synaptic dysregulations, which shift a balance between excitation and inhibition. To decipher the synaptic substrate of hyperexcitability, we examined pan-neuronal Tsc1 knockout mouse and found a reduction in surface expression of a GABA receptor (GABAR) subunit but not AMPA receptor (AMPAR) subunit. Read More

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http://dx.doi.org/10.1186/s13041-019-0427-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347813PMC
January 2019

Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations.

Mol Brain 2019 01 18;12(1). Epub 2019 Jan 18.

Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan.

Parkinson's disease (PD) is associated with both motor and non-motor symptoms, including constipation, sensory neuropathy, depression, dementia and sleep disorder. Somatostatin (SST) is considered to be a modulator of GABAergic inhibitory transmission, and its levels are reduced in cerebrospinal fluid of PD patients. In the present study, we evaluated the changes in the expression of SST in GABAergic neurons derived from induced pluripotent stem cells (iPSCs) of PD patients. Read More

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https://molecularbrain.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13041-019-0426-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339354PMC
January 2019
3 Reads

Pathological changes of distal motor neurons after complete spinal cord injury.

Mol Brain 2019 01 9;12(1). Epub 2019 Jan 9.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Traumatic spinal cord injury (SCI) causes serious disruption of neuronal circuits that leads to motor functional deficits. Regeneration of disrupted circuits back to their original target is necessary for the restoration of function after SCI, but the pathophysiological condition of the caudal spinal cord has not been sufficiently studied. Here we investigated the histological and biological changes in the distal part of the injured spinal cord, using a mice model of complete thoracic SCI in the chronic stage (3 months after injury). Read More

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http://dx.doi.org/10.1186/s13041-018-0422-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327522PMC
January 2019
1 Read

Artificial association of memory events by optogenetic stimulation of hippocampal CA3 cell ensembles.

Mol Brain 2019 01 8;12(1). Epub 2019 Jan 8.

Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan.

Previous gain-of-function studies using an optogenetic technique showed that manipulation of the hippocampal dentate gyrus or CA1 cell ensembles is important for memory reactivation and to generate synthetic or false memory. However, gain-of-function study manipulating CA3 cell ensembles has not been reported. The CA3 area of the hippocampus comprises a recurrent excitatory circuit, which is thought to be important for the generation of associations among the stored information within one brain region. Read More

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https://molecularbrain.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13041-018-0424-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323779PMC
January 2019
3 Reads

Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero.

Mol Brain 2019 01 8;12(1). Epub 2019 Jan 8.

Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, Japan.

The mammalian target of rapamycin (mTOR) signaling pathway plays a crucial role in cell metabolism, growth, and proliferation. The overactivation of mTOR has been implicated in the pathogenesis of syndromic autism spectrum disorder (ASD), such as tuberous sclerosis complex (TSC). Treatment with the mTOR inhibitor rapamycin improved social interaction deficits in mouse models of TSC. Read More

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http://dx.doi.org/10.1186/s13041-018-0423-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325753PMC
January 2019
2 Reads

The peacefulness gene promotes aggression in Drosophila.

Mol Brain 2019 01 3;12(1). Epub 2019 Jan 3.

Department of Neurology and Neurosurgery, McGill Centre for Research in Neuroscience, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4, Canada.

Natural aggressiveness is commonly observed in all animal species, and is displayed frequently when animals compete for food, territory and mating. Aggression is an innate behaviour, and is influenced by both environmental and genetic factors. However, the genetics of aggression remains largely unclear. Read More

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http://dx.doi.org/10.1186/s13041-018-0417-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318936PMC
January 2019
2 Reads

What does LTP tell us about the roles of CaMKII and PKMζ in memory?

Mol Brain 2018 12 28;11(1):77. Epub 2018 Dec 28.

Department of Physiology and Pharmacology, The Robert F. Furchgott Center for Neural and Behavioral Science, State University of New York Downstate Medical Center, Brooklyn, NY, 11203, USA.

In "Criteria for identifying the molecular basis of the engram (CaMKII, PKMζ)," Lisman proposes that elucidating the mechanism of LTP maintenance is key to understanding memory storage. He suggests three criteria for a maintenance mechanism to evaluate data on CaMKII and PKMζ as memory storage molecules: necessity, occlusion, and erasure. Here we show that when the criteria are tested, the results reveal important differences between the molecules. Read More

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http://dx.doi.org/10.1186/s13041-018-0420-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309091PMC
December 2018
1 Read

In memoriam: John Lisman - commentaries on CaMKII as a memory molecule.

Mol Brain 2018 12 28;11(1):76. Epub 2018 Dec 28.

Department of Biological Sciences, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.

Shortly before he died in October 2017, John Lisman submitted an invited review to Molecular Brain on 'Criteria for identifying the molecular basis of the engram (CaMKII, PKMζ)'. John had no opportunity to read the referees' comments, and as a mark of the regard in which he was held by the neuroscience community the Editors decided to publish his review as submitted. This obituary takes the form of a series of commentaries on Lisman's review. Read More

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https://molecularbrain.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13041-018-0419-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309094PMC
December 2018
7 Reads

EriB targeted inhibition of microglia activity attenuates MPP induced DA neuron injury through the NF-κB signaling pathway.

Mol Brain 2018 12 18;11(1):75. Epub 2018 Dec 18.

Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Accumulating evidence indicates that microglia activation is associated with an increased risk for developing Parkinson's disease (PD). With the progressive and selective degeneration of dopaminergic (DA) neurons, proinflammatory cytokines are elevated in the substantia nigra (SN) of PD patients. Thus, anti-inflammation has become one of the therapeutic strategies of PD. Read More

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http://dx.doi.org/10.1186/s13041-018-0418-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299497PMC
December 2018
4.345 Impact Factor

Hyperpolarized [1-13C] pyruvate MR spectroscopy detect altered glycolysis in the brain of a cognitively impaired mouse model fed high-fat diet.

Mol Brain 2018 12 18;11(1):74. Epub 2018 Dec 18.

Department of Anatomy, BK21 Project for Medical Science and Research Institute of Radiological Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Higher dietary intakes of saturated fatty acid increase the risk of developing Alzheimer's disease and dementia, and even in people without diabetes higher glucose levels may be a risk factor for dementia. The mechanisms causing neuronal dysfunction and dementia by consuming high-fat diet degrading the integrity of the blood-brain barrier (BBB) has been suggested but are not yet fully understood, and metabolic state of the brain by this type of insult is still veiled. The objective of this study was to investigate the effect of high-fat diet on the brain metabolism by a multimodal imaging method using the hyperpolarizedcarbon 13 (C)-pyruvate magnetic resonance (MR) spectroscopy and dynamic contrast-enhanced MR imaging in conjunction with the biochemical assay and the behavior test in a mouse model fed high-fat diet (HFD). Read More

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http://dx.doi.org/10.1186/s13041-018-0415-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299662PMC
December 2018

Systemic functional enrichment and ceRNA network identification following peripheral nerve injury.

Mol Brain 2018 12 17;11(1):73. Epub 2018 Dec 17.

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, Jiangsu Province, People's Republic of China, 226001.

Peripheral nerve injury is a worldwide clinical issue that impacts patients' quality of life and causes huge society and economic burden. Injured peripheral nerves are able to regenerate by themselves. However, for severe peripheral nerve injury, the regenerative abilities are very limited and the regenerative effects are very poor. Read More

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http://dx.doi.org/10.1186/s13041-018-0421-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297964PMC
December 2018

Dual roles of anterior cingulate cortex neurons in pain and pleasure in adult mice.

Mol Brain 2018 12 4;11(1):72. Epub 2018 Dec 4.

Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.

Human and animal studies indicate that some brain regions are activated during painful and pleasant situations, such as the anterior cingulate cortex (ACC). In the present study, we wanted to determine if some of the same neurons in the ACC may be activated by both pain and pleasure. We labeled neurons activated by two stimuli by using two immediate early genes (IEGs), Arc and Homer1a, and detected the intranuclear transcription of the IEG mRNA in situ. Read More

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https://molecularbrain.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13041-018-0416-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280384PMC
December 2018
1 Read

Transcriptome analysis of Shank3-overexpressing mice reveals unique molecular changes in the hypothalamus.

Mol Brain 2018 11 27;11(1):71. Epub 2018 Nov 27.

Department of Neuroscience, College of Medicine, Korea University, 73, Inchon-ro, Seongbuk-gu, Seoul, 02841, South Korea.

Various mutations in the SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene are associated with neurodevelopmental and neuropsychiatric disorders. Thus far, synaptic abnormalities in multiple brain regions, including the hippocampus, prefrontal cortex, striatum, and ventral tegmental area, have been investigated in several lines of Shank3 mutant mice. However, although some reports have shown loss and gain of body weight in Shank3 knock-out and overexpressing transgenic (TG) mice, respectively, the potential functions of Shank3 in the hypothalamus, a brain region critically involved in energy intake and expenditure, are unknown. Read More

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http://dx.doi.org/10.1186/s13041-018-0413-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257967PMC
November 2018

Accelerated FRET-PAINT microscopy.

Mol Brain 2018 11 22;11(1):70. Epub 2018 Nov 22.

Department of Physics and Astronomy, Seoul National University, Seoul, 08826, Republic of Korea.

Recent development of FRET-PAINT microscopy significantly improved the imaging speed of DNA-PAINT, the previously reported super-resolution fluorescence microscopy with no photobleaching problem. Here we try to achieve the ultimate speed limit of FRET-PAINT by optimizing the camera speed, dissociation rate of DNA probes, and bleed-through of the donor signal to the acceptor channel, and further increase the imaging speed of FRET-PAINT by 8-fold. Super-resolution imaging of COS-7 microtubules shows that high-quality 40-nm resolution images can be obtained in just tens of seconds. Read More

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http://dx.doi.org/10.1186/s13041-018-0414-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249777PMC
November 2018
5 Reads

Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma.

Mol Brain 2018 11 21;11(1):69. Epub 2018 Nov 21.

School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, CF24 4HQ, UK.

Retinal ganglion cell dendritic atrophy is an early feature of glaucoma, and the recovery of retinal ganglion cell dendrites is a viable option for vision improvement in glaucoma. Retinal ganglion cell neurites are surrounded by a specialised glycosaminoglycan extracellular matrix which inhibits dendritic plasticity. Since digestion of the extracellular matrix by chondroitinase ABC has been reported to have neuro-regenerative and neuro-plastic effects within the central nervous system, we explored its potential for dendritic recovery in a rat model of ocular hypertension. Read More

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http://dx.doi.org/10.1186/s13041-018-0412-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249825PMC
November 2018
10 Reads

proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing.

Mol Brain 2018 11 14;11(1):68. Epub 2018 Nov 14.

Serra Húnter fellow, Associate Professor, Generalitat de Catalunya, Barcelona, Spain.

Alzheimer disease (AD) is a complex pathology related to multiple causes including oxidative stress. Brain-derived neurotrophic factor (BDNF) is a neutrotrophic factor essential for the survival and differentiation of neurons and is considered a key target in the pathophysiology of various neurodegenerative diseases, as for example AD. Contrarily to BDNF, the precursor form of BDNF (proBDNF) induces apoptosis through the specific interaction with p75 and its co-receptor, Sortilin. Read More

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http://dx.doi.org/10.1186/s13041-018-0411-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237019PMC
November 2018
1 Read

Enhancement of dendritic persistent Na currents by mGluR5 leads to an advancement of spike timing with an increase in temporal precision.

Mol Brain 2018 11 9;11(1):67. Epub 2018 Nov 9.

Department of Physiology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Timing and temporal precision of action potential generation are thought to be important for encoding of information in the brain. The ability of single neurons to transform their input into output action potential is primarily determined by intrinsic excitability. Particularly, plastic changes in intrinsic excitability represent the cellular substrate for spatial memory formation in CA1 pyramidal neurons (CA1-PNs). Read More

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http://dx.doi.org/10.1186/s13041-018-0410-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230299PMC
November 2018

Development of a peptide targeting dopamine transporter to improve ADHD-like deficits.

Mol Brain 2018 11 9;11(1):66. Epub 2018 Nov 9.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8, Canada.

Attention-deficit hyperactivity disorder (ADHD) is a neurocognitive disorder characterized by hyperactivity, inattention, working memory deficits and impulsivity. Its worldwide prevalence is estimated to be 3-5% in children and adolescents. The mainstay treatment for ADHD is stimulant medications (e. Read More

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https://molecularbrain.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13041-018-0409-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234781PMC
November 2018
15 Reads
4.345 Impact Factor

Exposure to mild blast forces induces neuropathological effects, neurophysiological deficits and biochemical changes.

Mol Brain 2018 11 9;11(1):64. Epub 2018 Nov 9.

Departments of Surgery, Neurobiology, and Neurology, The University of Alabama at Birmingham Medical Center, 1720 2nd Ave S, THT 1052, Birmingham, AL, 35294, USA.

Direct or indirect exposure to an explosion can induce traumatic brain injury (TBI) of various severity levels. Primary TBI from blast exposure is commonly characterized by internal injuries, such as vascular damage, neuronal injury, and contusion, without external injuries. Current animal models of blast-induced TBI (bTBI) have helped to understand the deleterious effects of moderate to severe blast forces. Read More

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https://molecularbrain.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13041-018-0408-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225689PMC
November 2018
6 Reads

5-HTR and 5-HTR but not 5-HTR antagonism impairs the cross-modal reactivation of deprived visual cortex in adulthood.

Mol Brain 2018 11 6;11(1):65. Epub 2018 Nov 6.

Laboratory of Neuroplasticity and Neuroproteomics, Katholieke Universiteit Leuven, Naamsestraat 59, Box 2467, B-3000, Leuven, Belgium.

Visual cortical areas show enhanced tactile responses in blind individuals, resulting in improved behavioral performance. Induction of unilateral vision loss in adult mice, by monocular enucleation (ME), is a validated model for such cross-modal brain plasticity. A delayed whisker-driven take-over of the medial monocular zone of the visual cortex is preceded by so-called unimodal plasticity, involving the potentiation of the spared-eye inputs in the binocular cortical territory. Read More

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https://molecularbrain.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13041-018-0404-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218970PMC
November 2018
7 Reads

Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery.

Mol Brain 2018 10 25;11(1):63. Epub 2018 Oct 25.

Department of Medical Chemistry, Kansai Medical University, Hirakata, 573-1010, Japan.

Calcium/calmodulin-dependent serine protein kinase (CASK)-interacting protein 1 (Caskin1) is a direct binding partner of the synaptic adaptor protein CASK. Because Caskin1 forms homo-multimers and binds not only CASK but also other neuronal proteins in vitro, it is anticipated to have neural functions; but its exact role in mammals remains unclear. Previously, we showed that the concentration of Caskin1 in the spinal dorsal horn increases under chronic pain. Read More

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https://molecularbrain.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13041-018-0407-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202847PMC
October 2018
4 Reads

Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions.

Mol Brain 2018 10 25;11(1):62. Epub 2018 Oct 25.

Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada.

N-Methyl-D-aspartate receptors (NMDARs) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are two major types of ionotropic glutamate receptors involved in synaptic transmission. However, excessive activity of these receptors can be cytotoxic and thus their function must be precisely controlled. We have previously reported that NMDA receptor activity is dysregulated following genetic knockout of cellular prion protein (PrP), and that PrP regulation of NMDA receptors is copper-dependent. Read More

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http://dx.doi.org/10.1186/s13041-018-0406-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202830PMC
October 2018
1 Read

Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer's disease.

Mol Brain 2018 10 24;11(1):61. Epub 2018 Oct 24.

Department of Human Health Sciences, Graduated school of Medicine, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

The deposition of Amyloid-beta peptides (Aβ) is detected at an earlier stage in Alzheimer's disease (AD) pathology. Thus, the approach toward Aβ metabolism is considered to play a critical role in the onset and progression of AD. Mounting evidence suggests that lifestyle-related diseases are closely associated with AD, and exercise is especially linked to the prevention and the delayed progression of AD. Read More

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http://dx.doi.org/10.1186/s13041-018-0401-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201590PMC
October 2018
6 Reads

Disrupting USP5/Cav3.2 interactions protects female mice from mechanical hypersensitivity during peripheral inflammation.

Mol Brain 2018 10 19;11(1):60. Epub 2018 Oct 19.

Department of Physiology and Pharmacology, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute. Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Cav3.2 T-type calcium channels are important for the signaling of nociceptive information in the primary afferent pain pathway. During neuropathy and peripheral inflammation, Cav3. Read More

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https://molecularbrain.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13041-018-0405-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194615PMC
October 2018
10 Reads

Correction to: Novel and de novo mutations in pediatric refractory epilepsy.

Mol Brain 2018 10 16;11(1):59. Epub 2018 Oct 16.

Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China.

Following publication of the original article [1], the authors reported that one of the authors' names is spelled incorrectly. Read More

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http://dx.doi.org/10.1186/s13041-018-0399-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192341PMC
October 2018
5 Reads
4.345 Impact Factor

Spontaneous seizure and partial lethality of juvenile Shank3-overexpressing mice in C57BL/6 J background.

Mol Brain 2018 10 10;11(1):57. Epub 2018 Oct 10.

Department of Neuroscience, College of Medicine, Korea University, 73, Inchon-ro, Seongbuk-gu, Seoul, 02841, South Korea.

The SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene encodes core scaffolds in neuronal excitatory postsynapses. SHANK3 duplications have been identified in patients with hyperkinetic disorders and early-onset generalized tonic-clonic seizures. Consistently, Shank3 transgenic (TG) mice, which mildly overexpress Shank3 proteins exhibit hyperkinetic behavior and spontaneous seizures. Read More

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http://dx.doi.org/10.1186/s13041-018-0403-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180595PMC
October 2018
1 Read

Long non-coding RNA H19 and MALAT1 gene variants in patients with ischemic stroke in a northern Chinese Han population.

Mol Brain 2018 10 10;11(1):58. Epub 2018 Oct 10.

Department of Neurology, The First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Shenyang, 110001, China.

Objectives Long non-coding RNAs (lncRNAs) have been identified as key regulators in the development of atherosclerosis, which is a major cause of ischemic stroke. However, to date, there are no reports on the association between lncRNA gene variation and the risk of ischemic stroke. Therefore, we assessed the association between H19 and MALAT1 gene polymorphisms and susceptibility to ischemic stroke in a northern Chinese Han population. Read More

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http://dx.doi.org/10.1186/s13041-018-0402-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180423PMC
October 2018
2 Reads

Attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia.

Mol Brain 2018 10 1;11(1):56. Epub 2018 Oct 1.

Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.

The dentate gyrus of the hippocampus has been implicated in the pathophysiological basis of neuropsychiatric disorders including schizophrenia. We have identified several mouse models of neuropsychiatric disorders with robust molecular and functional defects in the dentate gyrus. Among them, mice lacking Schnurri-2 (Shn2 or HIVEP2) have been proposed as a model of schizophrenia and intellectual disability. Read More

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http://dx.doi.org/10.1186/s13041-018-0400-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167857PMC
October 2018
3 Reads

Plasticity changes in forebrain activity and functional connectivity during neuropathic pain development in rats with sciatic spared nerve injury.

Mol Brain 2018 10 1;11(1):55. Epub 2018 Oct 1.

Department of Life Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd, Taipei, 10617, Taiwan.

Neuropathic pain is a major worldwide health problem. Although central sensitization has been reported in well-established neuropathic conditions, information on the acute brain activation patterns in response to peripheral nerve injury is lacking. This study first mapped the brain activity in rats immediately following spared nerve injury (SNI) of the sciatic nerve. Read More

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http://dx.doi.org/10.1186/s13041-018-0398-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167811PMC
October 2018
1 Read

Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice.

Mol Brain 2018 09 21;11(1):54. Epub 2018 Sep 21.

Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.

Fragile X syndrome is caused by the loss of fragile X mental retardation protein (FMRP). Kainate receptor (KAR) is a subfamily of ionotropic glutamate receptors (iGluR) that acts mainly as a neuromodulator of synaptic transmission and neuronal excitability. However, little is known about the changes of synaptic KAR in the cortical area of Fmr1 KO mice. Read More

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http://dx.doi.org/10.1186/s13041-018-0396-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151036PMC
September 2018
13 Reads

Depressive symptoms are associated with a functional polymorphism in a miR-433 binding site in the FGF20 gene.

Mol Brain 2018 09 21;11(1):53. Epub 2018 Sep 21.

Laboratory of Neuropsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nariño, 110231, Bogotá, Colombia.

Genetic studies of major depressive disorder and its associated endophenotypes are useful for the identification of candidate genes. In recent years, variations in non-coding RNA genes, such as miRNAs, have been explored as novel candidates for psychiatric disorders and related endophenotypes. The aim of the present study was to evaluate the possible association between a functional polymorphism (rs12720208) in the FGF20 gene, which regulates its modulation by miR-433, and depressive symptoms in young adults. Read More

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http://dx.doi.org/10.1186/s13041-018-0397-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151041PMC
September 2018

The effect of Neuroligin-2 absence on sleep architecture and electroencephalographic activity in mice.

Mol Brain 2018 09 19;11(1):52. Epub 2018 Sep 19.

Research Center and Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal (CIUSSS-NIM), 5400 Gouin West blvd, Montréal, QC, H4J 1C5, Canada.

Sleep disorders are comorbid with most psychiatric disorders, but the link between these is not well understood. Neuroligin-2 (NLGN2) is a cell adhesion molecule that plays roles in synapse formation and neurotransmission. Moreover, NLGN2 has been associated with psychiatric disorders, but its implication in sleep remains underexplored. Read More

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http://dx.doi.org/10.1186/s13041-018-0394-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146600PMC
September 2018
1 Read

Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.

Mol Brain 2018 09 17;11(1):51. Epub 2018 Sep 17.

Neuropharmacology. Department of Traslational Neuroscience, Cajal Institute, CSIC, E-28002, Madrid, Spain.

Cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis sativa plant, exhibits therapeutic potential for various human diseases, including chronic neurodegenerative diseases, such as Alzheimer's and Parkinson's, ischemic stroke, epilepsy and other convulsive syndromes, neuropsychiatric disorders, neuropathic allodynia and certain types of cancer. CBD does not bind directly to endocannabinoid receptors 1 and 2, and despite research efforts, its specific targets remain to be fully identified. Notably, sigma 1 receptor (σ1R) antagonists inhibit glutamate N-methyl-D-aspartate acid receptor (NMDAR) activity and display positive effects on most of the aforesaid diseases. Read More

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http://dx.doi.org/10.1186/s13041-018-0395-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142691PMC
September 2018
1 Read

3D imaging of PSD-95 in the mouse brain using the advanced CUBIC method.

Mol Brain 2018 09 12;11(1):50. Epub 2018 Sep 12.

Illawarra Health and Medical Research Institute, Wollongong, NSW, 2522, Australia.

Aims: Postsynaptic density - 95 kDa protein (PSD95) is an important molecule on the postsynaptic membrane. It interacts with many other proteins and plays a pivotal role in learning and memory formation. Its distribution in the brain has been studied previously using in situ hybridization as well as immunohistochemistry. Read More

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http://dx.doi.org/10.1186/s13041-018-0393-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134724PMC
September 2018
2 Reads

Elevated contextual fear memory by SIRT6 depletion in excitatory neurons of mouse forebrain.

Mol Brain 2018 09 6;11(1):49. Epub 2018 Sep 6.

Laboratory of Neurobiology, School of Biological Sciences, Seoul National University, Seoul, 08826, South Korea.

A class of NAD-dependent protein deacetylases, the Sirtuin (SIRT) family of proteins is involved in aging, cell survival, and neurodegeneration. Recently, SIRT proteins, including SIRT6, have been reported to be important in learning and memory. However, the role of SIRT6 in excitatory brain neurons in cognitive behaviors is not well characterized. Read More

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http://dx.doi.org/10.1186/s13041-018-0391-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127998PMC
September 2018
16 Reads

Novel and de novo mutations in pediatric refractory epilepsy.

Mol Brain 2018 09 5;11(1):48. Epub 2018 Sep 5.

Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China.

Pediatric refractory epilepsy is a broad phenotypic spectrum with great genetic heterogeneity. Next-generation sequencing (NGS) combined with Sanger sequencing could help to understand the genetic diversity and underlying disease mechanisms in pediatric epilepsy. Here, we report sequencing results from a cohort of 172 refractory epilepsy patients aged 0-14 years. Read More

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https://molecularbrain.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13041-018-0392-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125990PMC
September 2018
15 Reads
4.345 Impact Factor

Control of occlusion of middle cerebral artery in perinatal and neonatal mice with magnetic force.

Mol Brain 2018 08 29;11(1):47. Epub 2018 Aug 29.

Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Ischemic perinatal stroke (IPS) is common, resulting in significant mortality and morbidity. In such cases, the incidence of unilateral arterial cerebral infarction is often occluded in the middle cerebral artery (MCA), leading to focal ischemia. In adult rodents, blockage of MCA is the most frequently used strategy for ischemic stroke study. Read More

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http://dx.doi.org/10.1186/s13041-018-0389-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114863PMC
August 2018
3 Reads

A zinc-finger fusion protein refines Gal4-defined neural circuits.

Mol Brain 2018 08 20;11(1):46. Epub 2018 Aug 20.

Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, Singapore, 138673, Singapore.

The analysis of behavior requires that the underlying neuronal circuits are identified and genetically isolated. In several major model species-most notably Drosophila-neurogeneticists identify and isolate neural circuits with a binary heterologous expression-control system: Gal4-UASG. One limitation of Gal4-UASG is that expression patterns are often too broad to map circuits precisely. Read More

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https://molecularbrain.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13041-018-0390-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102859PMC
August 2018
3 Reads

Multiple myosin motors interact with sodium/potassium-ATPase alpha 1 subunits.

Mol Brain 2018 08 7;11(1):45. Epub 2018 Aug 7.

Department of Neurology, Yale University Schoolof Medicine, New Haven, CT, 06510, USA.

The alpha1 (α1) subunit of the sodium/potassium ATPase (i.e., Na/K-ATPase α1), the prototypical sodium pump, is expressed in each eukaryotic cell. Read More

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http://dx.doi.org/10.1186/s13041-018-0388-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081954PMC

Stimulation-induced structural changes at the nucleus, endoplasmic reticulum and mitochondria of hippocampal neurons.

Mol Brain 2018 07 27;11(1):44. Epub 2018 Jul 27.

NINDS Electron Microscopy Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.

Neurons exhibit stimulation-induced ultrastructural changes such as increase of thickness and curvature of the postsynaptic density, decrease in contact area between subsurface cistern and plasma membrane, and formation of CaMKII clusters and synaptic spinules. These structural characteristics help in identifying the activity state of the neuron and should be taken into consideration when interpreting ultrastructural features of the neurons. Here in organotypic hippocampal slice cultures where experimental conditions can be easily manipulated, two additional features are documented in forebrain neurons as reliable benchmarks for stimulation-induced structural changes: (1) The neuronal nucleus showed conspicuous clustering of dark chromatin, and (2) the endoplasmic reticulum formed stacks with a uniform gap of ~ 13 nm filled with dark materials. Read More

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http://dx.doi.org/10.1186/s13041-018-0387-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062868PMC

Dysregulation of human NEFM and NEFH mRNA stability by ALS-linked miRNAs.

Mol Brain 2018 07 20;11(1):43. Epub 2018 Jul 20.

Molecular Medicine Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

Neurofilaments (NFs) are the most abundant cytoskeletal component of vertebrate myelinated axons. NFs function by determining axonal caliber, promoting axonal growth and forming a 3-dimensional lattice that supports the organization of cytoplasmic organelles. The stoichiometry of NF protein subunits (NFL, NFM and NFH) has to be tightly controlled to avoid the formation of NF neuronal cytoplasmic inclusions (NCIs), axonal degeneration and neuronal death, all pathological hallmarks of amyotrophic lateral sclerosis (ALS). Read More

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http://dx.doi.org/10.1186/s13041-018-0386-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054723PMC

Relationships between the acoustic startle response and prepulse inhibition in C57BL/6J mice: a large-scale meta-analytic study.

Mol Brain 2018 07 13;11(1):42. Epub 2018 Jul 13.

Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, 1-98 Dengakugakubo Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.

Prepulse inhibition (PPI) is the suppression of a startle reflex response to a startle stimulus that occurs when a weak prepulse stimulus precedes the startle stimulus. PPI is measured to assess sensorimotor gating across species, including humans and rodents. Reduced PPI, which is thought to reflect dysfunction of sensorimotor gating, is reported in patients with psychiatric disorders, such as schizophrenia, bipolar disorder, and post-traumatic stress disorder (PTSD), and in animal models of these disorders. Read More

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http://dx.doi.org/10.1186/s13041-018-0382-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044095PMC