887 results match your criteria Molecular Aspects of Medicine [Journal]


Anatomy and physiology of the nutritional system.

Authors:
Saverio Cinti

Mol Aspects Med 2019 Apr 10. Epub 2019 Apr 10.

University of Ancona (Politecnica delle Marche), Center of Obesity, Via Tronto 10a, 60020, Ancona, Italy; Policlinico Morgagni, Via Del Bosco 105, 95125 Catania, Italy. Electronic address:

The organisms of mammals are composed of organs cooperating as systems that are organized to perform functions which allow the survival of the individual and maintenance of the species. Thus, to reach the main goals of these functions we need systems that ensure nutrient uptake and distribution, thermogenesis, oxygen uptake and distribution, the discharge of toxic internal by-products, the defense from internal and external pathogens, gamete fertilization, and the fine-tuning of the activity of all the tissues composing the organs. Most of these activities also require interactions with the internal and external environment. Read More

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http://dx.doi.org/10.1016/j.mam.2019.04.001DOI Listing
April 2019
1 Read

Approaches to functionally validate candidate genetic variants involved in colorectal cancer predisposition.

Mol Aspects Med 2019 Apr 1. Epub 2019 Apr 1.

Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain. Electronic address:

Most next generation sequencing (NGS) studies identified candidate genetic variants predisposing to colorectal cancer (CRC) but do not tackle its functional interpretation to unequivocally recognize a new hereditary CRC gene. Besides, germline variants in already established hereditary CRC-predisposing genes or somatic variants share the same need when trying to categorize those with relevant significance. Functional genomics approaches have an important role in identifying the causal links between genetic architecture and phenotypes, in order to decipher cellular function in health and disease. Read More

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http://dx.doi.org/10.1016/j.mam.2019.03.004DOI Listing

MicroRNA-215: From biology to theranostic applications.

Mol Aspects Med 2019 Mar 26. Epub 2019 Mar 26.

Central European Institute of Technology, Masaryk University, Kamenice 753/5, 625 00, Brno, Czech Republic. Electronic address:

MicroRNA-215 (miR-215) is one of the extensively studied microRNAs (miRNAs) in human diseases, especially in different types of cancer, where it plays various roles in the initiation and progression of tumors. There is also a high conservation of miR-215 among wide range of different species indicating that this miRNA may have vital functions that are maintained during evolution. During the last ten years, significant efforts were dedicated to uncover molecular mechanisms of miR-215 regulation and cellular functioning. Read More

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http://dx.doi.org/10.1016/j.mam.2019.03.002DOI Listing
March 2019
1 Read

Functional roles of the human ribonuclease A superfamily in RNA metabolism and membrane receptor biology.

Mol Aspects Med 2019 Mar 25. Epub 2019 Mar 25.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX, 77030, USA; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung, 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan. Electronic address:

The human ribonuclease A (hRNase A) superfamily is comprised of 13 members of secretory RNases, most of which are recognized as catabolic enzymes for their ribonucleolytic activity to degrade ribonucleic acids (RNAs) in the extracellular space, where they play a role in innate host defense and physiological homeostasis. Interestingly, human RNases 9-13, which belong to a non-canonical subgroup of the hRNase A superfamily, are ribonucleolytic activity-deficient proteins with unclear biological functions. Moreover, accumulating evidence indicates that secretory RNases, such as human RNase 5, can be internalized into cells facilitated by membrane receptors like the epidermal growth factor receptor to regulate intracellular RNA species, in particular non-coding RNAs, and signaling pathways by either a ribonucleolytic activity-dependent or -independent manner. Read More

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http://dx.doi.org/10.1016/j.mam.2019.03.003DOI Listing

Update on genetic predisposition to colorectal cancer and polyposis.

Mol Aspects Med 2019 Mar 18. Epub 2019 Mar 18.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany. Electronic address:

The present article summarizes recent developments in the characterization of genetic predisposition to colorectal cancer (CRC). The main themes covered include new hereditary CRC and polyposis syndromes, non-CRC hereditary cancer genes found mutated in CRC patients, strategies used to identify novel causal genes, and review of candidate genes that have been proposed to predispose to CRC and/or colonic polyposis. We provide an overview of newly described genes and syndromes associated with predisposition to CRC and polyposis, including: polymerase proofreading-associated polyposis, NTHL1-associated polyposis, mismatch repair gene biallelic inactivation-related adenomatous polyposis (including MSH3- and MLH3-associated polyposes), GREM1-associated mixed polyposis, RNF43-associated serrated polyposis, and RPS20 mutations as a rare cause of hereditary nonpolyposis CRC. Read More

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http://dx.doi.org/10.1016/j.mam.2019.03.001DOI Listing
March 2019
3 Reads

Altered foetoplacental vascular endothelial signalling to insulin in diabesity.

Mol Aspects Med 2019 Mar 7. Epub 2019 Mar 7.

Cellular and Molecular Physiology Laboratory, Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, 8330024, Chile; Department of Physiology, Faculty of Pharmacy, Universidad de Sevilla, Seville, E-41012, Spain; University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, University of Queensland, Herston, QLD 4029, Queensland, Australia. Electronic address:

Obesity and type 2 diabetes mellitus (T2DM) are diseases associated with hypertension and metabolic alterations. A significant group of patients present both obesity and T2DM, a condition defined as diabesity. One of the metabolic features in these conditions is the clinical presentation of insulin resistance. Read More

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http://dx.doi.org/10.1016/j.mam.2019.02.003DOI Listing
March 2019
2 Reads

Glioma progression in diabesity.

Mol Aspects Med 2019 Mar 4. Epub 2019 Mar 4.

Molecular Pathology Laboratory, Institute of Biochemistry and Microbiology, Faculty of Sciences, Universidad Austral de Chile, Valdivia, 5090000, Chile. Electronic address:

Diabetes mellitus, obesity, and cancer are diseases that in recent years have caused a large number of deaths worldwide, so have been in the front line of biomedical research. On the other hand, obesity is a risk factor for several types of cancer and type 2 diabetes mellitus. The metabolic disorder and global inflammatory environment seen in obese patients is also critical for the treatment of both diabetes mellitus and gliomas. Read More

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http://dx.doi.org/10.1016/j.mam.2019.02.002DOI Listing
March 2019
4 Reads

Pathophysiology of Organ and Tissue Fibrosis.

Mol Aspects Med 2019 02;65

UCL Institute for Liver and Digestive Health, Division of Medicine - Royal Free Hospital, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2019.02.001DOI Listing
February 2019

Mendelian randomisation: A powerful and inexpensive method for identifying and excluding non-genetic risk factors for colorectal cancer.

Mol Aspects Med 2019 Feb 4. Epub 2019 Feb 4.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK; Division of Molecular Pathology, The Institute of Cancer Research, London, UK.

Colorectal cancer (CRC) is the third most common cancer in economically developed countries and a major cause of cancer-related mortality. The importance of lifestyle and diet as major determinants of CRC risk is suggested by differences in CRC incidence between countries and in migration studies. Previous observational epidemiological studies have identified associations between modifiable environmental risk factors and CRC, but these studies can be susceptible to reverse causation and confounding, and their results can therefore conflict. Read More

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http://dx.doi.org/10.1016/j.mam.2019.01.002DOI Listing
February 2019
2 Reads

Involvement of A adenosine receptors as anti-inflammatory in gestational diabesity.

Mol Aspects Med 2019 Jan 24. Epub 2019 Jan 24.

Cellular and Molecular Physiology Laboratory, Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, 8330024, Chile; Department of Physiology, Faculty of Pharmacy, Universidad de Sevilla, Seville, E-41012, Spain; University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, University of Queensland, Herston, QLD, 4029, Queensland, Australia. Electronic address:

Pregnant women that are obese may develop gestational diabetes mellitus (GDM) configuring a new metabolic condition referred to as gestational diabesity. The metabolic alterations seen in gestational diabesity include a combination of an exacerbated pro-inflammatory state and fetoplacental endothelial dysfunction. Also, gestational diabesity associates with supra-physiological extracellular concentration of adenosine in the foetoplacental blood. Read More

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http://dx.doi.org/10.1016/j.mam.2019.01.001DOI Listing
January 2019
9 Reads

Impaired signalling pathways mediated by extracellular vesicles in diabesity.

Mol Aspects Med 2019 Jan 14. Epub 2019 Jan 14.

University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, University of Queensland, Herston, QLD 4029, Queensland, Australia; Department of Physiology, Faculty of Pharmacy, Universidad de Sevilla, Seville, E-41012, Spain; Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, 8330024, Chile. Electronic address:

Diabesity, obesity, and type 2 diabetes mellitus (T2DM) are the most prevalent diseases nowadays and associate with high risk of cardiovascular complications. The impaired signalling pathways associated with the metabolism of D-glucose, lipids, and insulin have been studied for many years aiming to understand the cellular mechanisms of these diseases. Extracellular vesicles (EVs), including exosomes and microvesicles, carry different microRNAs or proteins as cargoes, acting as a mechanism of cell-to-cell communication to modulate different cell functions altering the metabolic regulatory pathways. Read More

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http://dx.doi.org/10.1016/j.mam.2018.12.001DOI Listing
January 2019
13 Reads

Diabesity-associated oxidative and inflammatory stress signalling in the early human placenta.

Mol Aspects Med 2018 Dec 15. Epub 2018 Dec 15.

Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria. Electronic address:

Early pregnancy is characterized by a series of complex and tightly regulated events to ultimately establish implantation and early placental development. One of the key events is the opening of the decidual spiral arteries into the intervillous space. It leads to a rise in oxygen tension in the intervillous space and the placenta and will induce transcriptional and translational changes of oxygen-sensitive molecules including antioxidants. Read More

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http://dx.doi.org/10.1016/j.mam.2018.11.002DOI Listing
December 2018
16 Reads

Diabesity and mood disorders: Multiple links through the microbiota-gut-brain axis.

Mol Aspects Med 2018 Dec 12. Epub 2018 Dec 12.

Research Unit of Translational Neurogastroenterology, Division of Pharmacology, Otto Loewi Research Centre, Medical University of Graz, Universitätsplatz 4, A-8010 Graz, Austria; BioTechMed-Graz, Mozartgasse 12, A-8010 Graz, Austria. Electronic address:

The global prevalence of diabesity is on the rise, and the clinical, social and economic health burden arising from this epidemic is aggravated by a significant co-morbidity of diabesity with neuropsychiatric disease, particularly depression. Importantly, not only is the prevalence of mood disorders elevated in patients with type 2 diabetes, depressed patients are also more prone to develop diabetes. This reciprocal relationship calls for a molecular and systemic analysis of diabesity-brain interactions to guide preventive and therapeutic strategies. Read More

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http://dx.doi.org/10.1016/j.mam.2018.11.003DOI Listing
December 2018
24 Reads

Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity.

Mol Aspects Med 2018 Nov 27. Epub 2018 Nov 27.

Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, 8330024, Chile; Department of Physiology, Faculty of Pharmacy, Universidad de Sevilla, Seville, E-41012, Spain; University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, University of Queensland, Herston, QLD 4029, Queensland, Australia. Electronic address:

Diabesity is an abnormal metabolic condition shown by patients with obesity that develop type 2 diabetes mellitus. Patients with diabesity present with insulin resistance, reduced vascular response to insulin, and vascular endothelial dysfunction. Along with the several well-described mechanisms of insulin resistance, a state of endoplasmic reticulum (ER) stress, where the primary human targets are the adipose tissue, liver, skeletal muscle, and the foetoplacental vasculature, is apparent. Read More

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http://dx.doi.org/10.1016/j.mam.2018.11.001DOI Listing
November 2018
2 Reads

Diabesity and antidiabetic drugs.

Mol Aspects Med 2018 Nov 15. Epub 2018 Nov 15.

Department of Endocrinology & Diabetes, Jersey Hospital, Jersey, JE1 4SE, United Kingdom.

The prevalence of "diabesity" - diabetes related to obesity - has increased tremendously over the past few decades because of the global obesity epidemic. Although bariatric surgery is the best treatment option for patients with diabesity, a majority of patients are managed only with antidiabetic drugs for various reasons. Diabetes control with antidiabetic agents may affect diabesity outcomes positively or negatively because of their effects on body weight and other metabolic parameters. Read More

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http://dx.doi.org/10.1016/j.mam.2018.10.004DOI Listing
November 2018
16 Reads

Intestinal fibrosis.

Mol Aspects Med 2019 02 2;65:100-109. Epub 2018 Nov 2.

First Department of Internal Medicine, San Matteo Hospital Foundation, University of Pavia, Pavia, Italy. Electronic address:

Extensive tissue fibrosis is the end-stage process of a number of chronic conditions affecting the gastrointestinal tract, including inflammatory bowel disease (Crohn's disease, ulcerative colitis), ulcerative jejunoileitis, and radiation enteritis. Fibrogenesis is a physiological, reparative process that may become harmful as a consequence of the persistence of a noxious agent, after an excessive duration of the healing process. In this case, after replacement of dead or injured cells, fibrogenesis continues to substitute normal parenchymal tissue with fibrous connective tissue, leading to uncontrolled scar formation and, ultimately, permanent organ damage, loss of function, and/or strictures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00982997183010
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http://dx.doi.org/10.1016/j.mam.2018.10.003DOI Listing
February 2019
8 Reads
10.240 Impact Factor

Diabesity and brain disturbances: A metabolic perspective.

Mol Aspects Med 2018 Oct 15. Epub 2018 Oct 15.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal; Institute of Physiology - Faculty of Medicine - University of Coimbra, 3000-548, Coimbra, Portugal. Electronic address:

The last decades have been marked by an increased prevalence in non-communicable diseases such as obesity and type 2 diabetes (T2D) as well as by population aging and age-related (brain) diseases. The current notion that the brain and the body are interrelated units is gaining the attention of the scientific and medical community. Growing evidence demonstrates that there is a significant overlap in risk, comorbidity, and pathophysiological mechanisms across obesity, T2D and brain disturbances; settings that seem to be worsened when both obesity and T2D occur simultaneously, the so-called diabesity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00982997183007
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http://dx.doi.org/10.1016/j.mam.2018.10.002DOI Listing
October 2018
1 Read
10.240 Impact Factor

Endocannabinoids, exercise, pain, and a path to health with aging.

Authors:
Bruce A Watkins

Mol Aspects Med 2018 12 5;64:68-78. Epub 2018 Oct 5.

Department of Nutrition, University of California, Davis, CA, USA. Electronic address:

Physical activity is an important lifestyle factor for growth, development, and sustained health throughout life. In recent years, the benefits of physical activity have drawn more attention to its physiological effects on the body, including well-being. The endocannabinoid system (ECS) has emerged as a focal point to ascertain the mechanisms for how exercise benefits the body and how it reduces or controls pain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00982997183003
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http://dx.doi.org/10.1016/j.mam.2018.10.001DOI Listing
December 2018
13 Reads

Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection.

Authors:
Nicolas G Bazan

Mol Aspects Med 2018 12 1;64:18-33. Epub 2018 Oct 1.

Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, 70112, USA. Electronic address:

The functional significance of the selective enrichment of the omega-3 essential fatty acid docosahexaenoic acid (DHA; 22C and 6 double bonds) in cellular membrane phospholipids of the nervous system is being clarified by defining its specific roles on membrane protein function and by the uncovering of the bioactive mediators, docosanoids and elovanoids (ELVs). Here, we describe the preferential uptake and DHA metabolism in photoreceptors and brain as well as the significance of the Adiponectin receptor 1 in DHA retention and photoreceptor cell (PRC) survival. We now know that this integral membrane protein is engaged in DHA retention as a necessary event for the function of PRCs and retinal pigment epithelial (RPE) cells. Read More

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http://dx.doi.org/10.1016/j.mam.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204315PMC
December 2018
2 Reads

Signaling by Reactive Oxygen Species.

Authors:

Mol Aspects Med 2018 10;63:1-2

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http://dx.doi.org/10.1016/j.mam.2018.09.001DOI Listing
October 2018

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues.

Mol Aspects Med 2019 02 13;65:37-55. Epub 2018 Sep 13.

UCL Institute for Liver and Digestive Health, Division of Medicine - Royal Free Hospital, London, United Kingdom.

The progression of chronic liver diseases (CLD), irrespective of etiology, involves chronic parenchymal injury, persistent activation of inflammatory response as well as sustained activation of liver fibrogenesis and wound healing response. Liver fibrogenesis, is a dynamic, highly integrated molecular, cellular and tissue process responsible for driving the excess accumulation of extracellular matrix (ECM) components (i.e. Read More

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http://dx.doi.org/10.1016/j.mam.2018.09.002DOI Listing
February 2019
1 Read

Oxidation of cardiac myofilament proteins: Priming for dysfunction?

Mol Aspects Med 2018 10 23;63:47-58. Epub 2018 Aug 23.

King's British Heart Foundation Centre, King's College London, UK.

Oxidants are produced endogenously and can react with and thereby post-translationally modify target proteins. They have been implicated in the redox regulation of signal transduction pathways conferring protection, but also in mediating oxidative stress and causing damage. The difference is that in scenarios of injury the amount of oxidants generated is higher and/or the duration of oxidant exposure sustained. Read More

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http://dx.doi.org/10.1016/j.mam.2018.08.003DOI Listing
October 2018
2 Reads

Developmental pathways in the pathogenesis of lung fibrosis.

Mol Aspects Med 2019 02 23;65:56-69. Epub 2018 Aug 23.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. Electronic address:

Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival is between 3 and 5 years after diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00982997183007
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http://dx.doi.org/10.1016/j.mam.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374163PMC
February 2019
7 Reads

Omega-3 fatty acids and leukocyte-endothelium adhesion: Novel anti-atherosclerotic actions.

Mol Aspects Med 2018 12 13;64:169-181. Epub 2018 Aug 13.

Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, United Kingdom. Electronic address:

Endothelial cells (ECs) play a role in the optimal function of blood vessels. When endothelial function becomes dysregulated, the risk of developing atherosclerosis increases. Specifically, upregulation of adhesion molecule expression on ECs promotes the movement of leukocytes, particularly monocytes, into the vessel wall. Read More

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http://dx.doi.org/10.1016/j.mam.2018.08.002DOI Listing
December 2018
2 Reads

MicroRNA in lung cancer: role, mechanisms, pathways and therapeutic relevance.

Mol Aspects Med 2018 Aug 17. Epub 2018 Aug 17.

Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia (A Central University), New Delhi-110025, India. Electronic address:

Lung cancer is the cardinal cause of cancer-related deaths with restricted recourse of therapy throughout the world. Clinical success of therapies is not very promising due to - late diagnosis, limited therapeutic tools, relapse and the development of drug resistance. Recently, small ∼20-24 nucleotides molecules called microRNAs (miRNAs) have come into the limelight as they play outstanding role in the process of tumorigenesis by regulating cell cycle, metastasis, angiogenesis, metabolism and apoptosis. Read More

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http://dx.doi.org/10.1016/j.mam.2018.07.003DOI Listing
August 2018
24 Reads
10.240 Impact Factor

Oxidative stress in chronic lung disease: From mitochondrial dysfunction to dysregulated redox signaling.

Mol Aspects Med 2018 10 22;63:59-69. Epub 2018 Aug 22.

Department of Pathology and Laboratory Medicine, Vermont Lung Center, Larner College of Medicine, University of Vermont, Burlington, VT, 05405, USA.

The lung is a delicate organ with a large surface area that is continuously exposed to the external environment, and is therefore highly vulnerable to exogenous sources of oxidative stress. In addition, each of its approximately 40 cell types can also generate reactive oxygen species (ROS), as byproducts of cellular metabolism and in a more regulated manner by NOX enzymes with functions in host defense, immune regulation, and cell proliferation or differentiation. To effectively regulate the biological actions of exogenous and endogenous ROS, various enzymatic and non-enzymatic antioxidant defense systems are present in all lung cell types to provide adequate protection against their injurious effects and to allow for appropriate ROS-mediated biological signaling. Read More

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http://dx.doi.org/10.1016/j.mam.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181583PMC
October 2018
3 Reads

Control of SUMO and Ubiquitin by ROS: Signaling and disease implications.

Mol Aspects Med 2018 10 4;63:3-17. Epub 2018 Aug 4.

Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ - ZMBH Alliance, Heidelberg, Germany. Electronic address:

Reversible post-translational modifications (PTMs) ensure rapid signal transmission from sensors to effectors. Reversible modification of proteins by the small proteins Ubiquitin and SUMO are involved in virtually all cellular processes and can modify thousands of proteins. Ubiquitination or SUMOylation is the reversible attachment of these modifiers to lysine residues of a target via isopeptide bond formation. Read More

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http://dx.doi.org/10.1016/j.mam.2018.07.002DOI Listing
October 2018
5 Reads

Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities.

Mol Aspects Med 2019 02 2;65:70-99. Epub 2018 Aug 2.

The Wilf Family Cardiovascular Research Institute, Department of Medicine (Cardiology), Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forchheimer G46B, Bronx, NY, 10461, USA. Electronic address:

Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases, and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse outcome. Because the adult mammalian heart has negligible regenerative capacity, death of a large number of cardiomyocytes results in reparative fibrosis, a process that is critical for preservation of the structural integrity of the infarcted ventricle. On the other hand, pathophysiologic stimuli, such as pressure overload, volume overload, metabolic dysfunction, and aging may cause interstitial and perivascular fibrosis in the absence of infarction. Read More

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http://dx.doi.org/10.1016/j.mam.2018.07.001DOI Listing
February 2019
24 Reads

Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications.

Mol Aspects Med 2019 02 30;65:2-15. Epub 2018 Jun 30.

Dept. of Medicine III, University Hospital Aachen, Germany. Electronic address:

Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to injury in many tissues. Although the extracellular matrix deposition appears unstructured disrupting the normal tissue architecture and subsequently impairing proper organ function, fibrogenesis is a highly orchestrated process determined by defined sequences of molecular signals and cellular response mechanisms. Persistent injury and parenchymal cell death provokes tissue inflammation, macrophage activation and immune cell infiltration. Read More

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http://dx.doi.org/10.1016/j.mam.2018.06.003DOI Listing
February 2019
57 Reads

Cellular and molecular mechanisms of kidney fibrosis.

Mol Aspects Med 2019 02 22;65:16-36. Epub 2018 Jun 22.

Institute of Pathology, RWTH University of Aachen, Germany; Division of Nephrology, RWTH University of Aachen, Germany. Electronic address:

Renal fibrosis is the final pathological process common to any ongoing, chronic kidney injury or maladaptive repair. It is considered as the underlying pathological process of chronic kidney disease (CKD), which affects more than 10% of world population and for which treatment options are limited. Renal fibrosis is defined by excessive deposition of extracellular matrix, which disrupts and replaces the functional parenchyma that leads to organ failure. Read More

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http://dx.doi.org/10.1016/j.mam.2018.06.002DOI Listing
February 2019
2 Reads

Bioactives and their impact on human health.

Mol Aspects Med 2018 06;61

Department of Nutrition, University of California, Davis, CA, USA; Department of Environmental Toxicology, University of California, Davis, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2018.06.001DOI Listing

Omega-3 fatty acids, membrane remodeling and cancer prevention.

Mol Aspects Med 2018 12 12;64:79-91. Epub 2018 Apr 12.

Program in Integrative Nutrition & Complex Diseases, Texas A&M University, USA; Faculty of Toxicology, Texas A&M University, USA; Department of Nutrition & Food Science, Texas A&M University, USA; Center for Translational Environmental Health Research, Texas A&M University, USA. Electronic address:

Proteins are often credited as the macromolecule responsible for performing critical cellular functions, however lipids have recently garnered more attention as our understanding of their role in cell function and human health becomes more apparent. Although cellular membranes are the lipid environment in which many proteins function, it is now apparent that protein and lipid assemblies can be organized to form distinct micro- or nanodomains that facilitate signaling events. Indeed, it is now appreciated that cellular function is partly regulated by the specific spatiotemporal lipid composition of the membrane, down to the nanosecond and nanometer scale. Read More

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http://dx.doi.org/10.1016/j.mam.2018.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185832PMC
December 2018
5 Reads

More than a syllable in fib-ROS-is: The role of ROS on the fibrotic extracellular matrix and on cellular contacts.

Mol Aspects Med 2018 10 6;63:30-46. Epub 2018 Apr 6.

Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Waldeyerstr. 15, 48149 Münster, Germany. Electronic address:

Fibrosis is characterized by excess deposition of extracellular matrix (ECM). However, the ECM changes during fibrosis not only quantitatively but also qualitatively. Thus, the composition is altered as the expression of various ECM proteins changes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00982997173016
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http://dx.doi.org/10.1016/j.mam.2018.03.005DOI Listing
October 2018
7 Reads

Biological activities of non-enzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) derived from EPA and DHA: New anti-arrhythmic compounds?

Mol Aspects Med 2018 12 27;64:161-168. Epub 2018 Mar 27.

Université de Montpellier, CNRS, Inserm, PhyMedExp, Montpellier, France.

ω3 Polyunsaturated fatty acids (ω3 PUFAs) have several biological properties including anti-arrhythmic effects. However, there are some evidences that it is not solely ω3 PUFAs per se that are biologically active but the non-enzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) like isoprostanes and neuroprostanes. Recent question arises how these molecules take part in physiological homeostasis, show biological bioactivities and anti-inflammatory properties. Read More

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http://dx.doi.org/10.1016/j.mam.2018.03.003DOI Listing
December 2018
17 Reads

N-Docosahexaenoylethanolamine: A neurotrophic and neuroprotective metabolite of docosahexaenoic acid.

Mol Aspects Med 2018 12 27;64:34-44. Epub 2018 Mar 27.

Laboratory of Molecular Signaling, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9410, United States.

N-Docosahexaenoylethanolamine (synaptamide) is an endocannabinoid-like metabolite endogenously synthesized from docosahexaenoic acid (DHA, 22:6n-3), the major omega-3 polyunsaturated fatty acid present in the brain. Although its biosynthetic mechanism has yet to be established, there is a closely linked relationship between the levels of synaptamide and its precursor DHA in the brain. Synaptamide at nanomolar concentrations promotes neurogenesis, neurite outgrowth and synaptogenesis in developing neurons. Read More

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http://dx.doi.org/10.1016/j.mam.2018.03.004DOI Listing
December 2018
3 Reads

ROS signaling and ER stress in cardiovascular disease.

Mol Aspects Med 2018 10 22;63:18-29. Epub 2018 Mar 22.

Department of Internal Medicine, Pulmonary and Critical Care, University of Texas Southwestern, Dallas, TX, USA. Electronic address:

The endoplasmic reticulum (ER) produces the vast majority of all proteins secreted into the extracellular space, including hormones and cytokines, as well as cell surface receptors and other proteins which interact with the environment. Accordingly, this organelle controls essentially all vital links to a cell's external milieu, responding to systemic metabolic, inflammatory, endocrine, and mechanical stimuli. The central role the ER plays in meeting protein synthetic and quality control requirements in the face of such demands is matched by an extensive and versatile ER stress response signaling network. Read More

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http://dx.doi.org/10.1016/j.mam.2018.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139279PMC
October 2018
5 Reads

Omega-3 fatty acids and non-alcoholic fatty liver disease: Evidence of efficacy and mechanism of action.

Mol Aspects Med 2018 12 22;64:135-146. Epub 2018 Mar 22.

Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK; National Institute for Health Research, Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.

For many years it has been known that high doses of long chain omega-3 fatty acids are beneficial in the treatment of hypertriglyceridaemia. Over the last three decades, there has also been a wealth of in vitro and in vivo data that has accumulated to suggest that long chain omega-3 fatty acid treatment might be beneficial to decrease liver triacylglycerol. Several biological mechanisms have been identified that support this hypothesis; notably, it has been shown that long chain omega-3 fatty acids have a beneficial effect: a) on bioactive metabolites involved in inflammatory pathways, and b) on alteration of nuclear transcription factor activities such as peroxisome proliferator-activated receptors (PPARs), sterol regulatory element-binding protein 1c (SREBP-1c) and carbohydrate-responsive element-binding protein (ChREBP), involved in inflammatory pathways and liver lipid metabolism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00982997183001
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http://dx.doi.org/10.1016/j.mam.2018.03.001DOI Listing
December 2018
5 Reads

Redox control in cancer development and progression.

Mol Aspects Med 2018 10 5;63:88-98. Epub 2018 Mar 5.

Institute for Cardiovascular Physiology, Goethe-University Frankfurt, 60590 Frankfurt am Main, Germany. Electronic address:

Cancer is the leading cause of death worldwide after cardiovascular diseases. This has been the case for the last few decades despite there being an increase in the number of cancer treatments. One reason for the apparent lack of drug effectiveness might be, at least in part, due to unspecificity for tumors; which often leads to substantial side effects. Read More

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http://dx.doi.org/10.1016/j.mam.2018.02.003DOI Listing
October 2018
8 Reads

Subpopulations of extracellular vesicles and their therapeutic potential.

Mol Aspects Med 2018 04 16;60:1-14. Epub 2018 Feb 16.

Krefting Research Centre, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Sweden. Electronic address:

Extracellular vesicles (EVs), such as exosomes and microvesicles, have over the last 10-15 years been recognized to convey key messages in the molecular communication between cells. Indeed, EVs have the capacity to shuttle proteins, lipids, and nucleotides such as RNA between cells, leading to an array of functional changes in the recipient cells. Importantly, the EV secretome changes significantly in diseased cells and under conditions of cellular stress. Read More

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http://dx.doi.org/10.1016/j.mam.2018.02.002DOI Listing
April 2018
3 Reads

Recommending flavanols and procyanidins for cardiovascular health: Revisited.

Mol Aspects Med 2018 06 23;61:63-75. Epub 2018 Feb 23.

Mars, Incorporated, 6885 Elm St, McLean, VA, 22101 USA.

The last 8 years have seen significant developments in our understanding of dietary flavanols and procyanidins in the context of human health and nutrition. During the same time, recognition of the importance of nutrition in primary disease prevention and health maintenance has increased. In addition, the concept of dietary bioactives (food constituents that although not essential to human life and procreation, may nevertheless play an important role in disease risk reduction, primary disease prevention, and healthy aging) has been created and developed. Read More

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http://dx.doi.org/10.1016/j.mam.2018.02.001DOI Listing
June 2018
2 Reads

Plant bioactives and redox signaling: (-)-Epicatechin as a paradigm.

Mol Aspects Med 2018 06 10;61:31-40. Epub 2018 Feb 10.

Fisicoquímica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina; Instituto de Bioquímica y Medicina Molecular (IBIMOL), Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina.

Polyphenols are bioactives claimed to be responsible for some of the health benefits provided by fruit and vegetables. It is currently accepted that the bioactivities of polyphenols can be mostly ascribed to their interactions with proteins and lipids. Such interactions can affect cell oxidant production and cell signaling, and explain in part the ability of polyphenols to promote health. Read More

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http://dx.doi.org/10.1016/j.mam.2018.01.007DOI Listing
June 2018
2 Reads

PDGF-C and PDGF-D signaling in vascular diseases and animal models.

Mol Aspects Med 2018 08 14;62:1-11. Epub 2018 Feb 14.

Division of Drug Research, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. Electronic address:

Members of the platelet-derived growth factor (PDGF) family are well known to be involved in different pathological conditions. The cellular and molecular mechanisms induced by the PDGF signaling have been well studied. Nevertheless, there is much more to discover about their functions and some important questions to be answered. Read More

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http://dx.doi.org/10.1016/j.mam.2018.01.005DOI Listing
August 2018
4 Reads

PDGF/PDGFR axis in the neural systems.

Mol Aspects Med 2018 08 6;62:63-74. Epub 2018 Feb 6.

Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address:

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are expressed in several cell types including the brain cells such as neuronal progenitors, neurons, astrocytes, and oligodendrocytes. Emerging evidence shows that PDGF-mediated signaling regulates diverse functions in the central nervous system (CNS) such as neurogenesis, cell survival, synaptogenesis, modulation of ligand-gated ion channels, and development of specific types of neurons. Interestingly, PDGF/PDFGR signaling can elicit paradoxical roles in the CNS, depending on the cell type and the activation stimuli and is implicated in the pathogenesis of various neurodegenerative diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00982997173013
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http://dx.doi.org/10.1016/j.mam.2018.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003857PMC
August 2018
8 Reads
10.240 Impact Factor

Omega-3 fatty acids and adipose tissue biology.

Mol Aspects Med 2018 12 17;64:147-160. Epub 2018 Jan 17.

Department of Adipose Tissue Biology, Institute of Physiology of the Czech Academy of Sciences, Videnska, 1083 Prague 4, Czech Republic. Electronic address:

This review provides evidence for the importance of white and brown adipose tissue (i.e. WAT and BAT) function for the maintenance of healthy metabolic phenotype and its preservation in response to omega-3 polyunsaturated fatty acids (omega-3 PUFA), namely in the context of diseased states linked to aberrant accumulation of body fat, systemic low-grade inflammation, dyslipidemia and insulin resistance. Read More

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http://dx.doi.org/10.1016/j.mam.2018.01.004DOI Listing
December 2018
10 Reads

Redox-signals and macrophage biology.

Mol Aspects Med 2018 10 12;63:70-87. Epub 2018 Jan 12.

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany; Project Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology, IME, 60590 Frankfurt, Germany. Electronic address:

Macrophages are known for their versatile role in biology. They sense and clear structures that contain exogenous or endogenous pathogen-associated molecular patterns. This process is tightly linked to the production of a mixture of potentially harmful oxidants and cytokines. Read More

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http://dx.doi.org/10.1016/j.mam.2018.01.003DOI Listing
October 2018
40 Reads

The role of fatty acids and their endocannabinoid-like derivatives in the molecular regulation of appetite.

Authors:
Renger F Witkamp

Mol Aspects Med 2018 12 19;64:45-67. Epub 2018 Jan 19.

Division of Human Nutrition and Health, Wageningen University, The Netherlands. Electronic address:

Intake, absorption and synthesis of fatty acids, including those produced by the intestinal microbiota are tightly monitored via specific receptors and, indirectly through their conversion into a variety of signalling molecules. The resulting information is integrated and translated to different physiological processes, including the regulation of appetite and satiation. Direct chemosensing of fatty acids takes place via interaction with free fatty acid (FFA) and other receptors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00982997173014
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http://dx.doi.org/10.1016/j.mam.2018.01.002DOI Listing
December 2018
10 Reads
1 Citation
10.240 Impact Factor

Flavonoids and the gastrointestinal tract: Local and systemic effects.

Mol Aspects Med 2018 06 12;61:41-49. Epub 2018 Jan 12.

Department of Food Science and Technology, University of California, Davis, USA; Department of Viticulture and Enology, University of California, Davis, USA.

The gastrointestinal (GI) tract plays a central role in the absorption, distribution, metabolism, and excretion of flavonoids, which ultimately define the health effects of these bioactives. These aspects are modulated by the interactions of flavonoids with other dietary components, environmental factors, the host, and the GI microbiota. Flavonoid can target molecules in the luminal content, the different GI tract cell types, and the microbiota. Read More

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http://dx.doi.org/10.1016/j.mam.2018.01.001DOI Listing
June 2018
3 Reads

Brain docosahexaenoic acid uptake and metabolism.

Mol Aspects Med 2018 12 9;64:109-134. Epub 2018 Feb 9.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College St., Toronto, Ontario, M5S 3E2, Canada. Electronic address:

Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the brain where it serves to regulate several important processes and, in addition, serves as a precursor to bioactive mediators. Given that the capacity of the brain to synthesize DHA locally is appreciably low, the uptake of DHA from circulating lipid pools is essential to maintaining homeostatic levels. Although, several plasma pools have been proposed to supply the brain with DHA, recent evidence suggests non-esterified-DHA and lysophosphatidylcholine-DHA are the primary sources. Read More

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http://dx.doi.org/10.1016/j.mam.2017.12.004DOI Listing
December 2018
4 Reads

Foetoplacental communication via extracellular vesicles in normal pregnancy and preeclampsia.

Mol Aspects Med 2018 04 13;60:69-80. Epub 2017 Dec 13.

Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile; Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, Seville E-41012, Spain; University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, University of Queensland, Herston, QLD 4029 Queensland, Australia. Electronic address:

Intercellular communication is a critical process in biological mechanisms. During pregnancy foetoplacental tissues release a heterogeneous group of extracellular vesicles (EVs) that include exosomes, microvesicles, apoptotic bodies, and syncytial nuclear aggregates. These vesicles contain a complex cargo (proteins, DNA, mRNA transcripts, microRNAs, noncoding RNA, lipids, and other molecules) that actively participate in the maternal-foetal communication by modulating different processes during gestation for a successful foetal development. Read More

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http://dx.doi.org/10.1016/j.mam.2017.12.002DOI Listing
April 2018
6 Reads

Role of extracellular vesicles in glioma progression.

Mol Aspects Med 2018 04 13;60:38-51. Epub 2017 Dec 13.

Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile; Department of Physiology, Faculty of Pharmacy, Universidad de Sevilla, Seville E-41012, Spain; University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, University of Queensland, Herston, QLD 4029, Queensland, Australia. Electronic address:

The role of extracellular vesicles in cancer biology has emerged as a focus of the study of great importance and has been shown to directly influence tumour development in several cancers including brain tumours, such as gliomas. Gliomas are the most aggressive brain tumours, and in the last time, a considerable effort has been made to understand their biology. Studies focus in the signalling pathways involved in the processes of angiogenesis, viability, drug resistance and immune response evasion, as well as gliomas ability to infiltrate healthy tissue, a phenomenon regulated by the migratory and invasive capacity of the cells within a tumour. Read More

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http://dx.doi.org/10.1016/j.mam.2017.12.003DOI Listing
April 2018
8 Reads