608 results match your criteria Moisturizers


Out-of-pocket Costs for Individuals with Atopic Eczema: A Cross-sectional Study in Nine European Countries.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology and Allergy, Technical University Munich, Biedersteinerstrasse 29, DE-80802 Munich, Germany.

Atopic eczema (AE) is one of the most common non-communicable inflammatory skin diseases, and has a huge socioeconomic impact. Studies on the everyday economic impact of AE on patients, however, are limited. To estimate the annual extra out-of-pocket spending due to AE among patients in Europe, a cross-sectional study using computer-assisted phone interviewing of patients with AE was performed in 9 European countries. Read More

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http://www.medicaljournals.se/acta/content/abstract/10.2340/
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http://dx.doi.org/10.2340/00015555-3102DOI Listing
December 2018
5 Reads

Sex- and age-adjusted prevalence estimates of skin types and unpleasant skin sensations and their consequences on the quality of life: Results from a study of a large representative sample of the French population.

Br J Dermatol 2018 Nov 30. Epub 2018 Nov 30.

Société Française de Dermatologie (SFD), Paris, France.

In France, the consumption of cosmetics was recently evaluated: the mean number of cosmetic products used daily by French consumers is 16 for women (18 if they are pregnant), 8 for men, 7 for girls (4-14 years old), 5 for boys (4-14 years old) and 6 for babies (0-3 years old, both sexes) , especially facial moisturizers, with a higher product exposure amounts than expected. Nonetheless, little is known about the prevalence of cosmetic disorders in the general population. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/bjd.17467DOI Listing
November 2018

Cosmeceuticals: What's Real, What's Not.

Dermatol Clin 2019 Jan 1;37(1):107-115. Epub 2018 Nov 1.

Dermatology Consulting Services, PLLC, 2444 North Main Street, High Point, NC 27262, USA. Electronic address:

Cosmeceuticals are cosmetics that promise to deliver physiologically relevant benefits without the incorporation of prescription drugs. To entice consumers to purchase these premium priced products, a story must be told of how the cosmeceutical delivers on these appearance improvement promises. The backbone of any cosmeceutical skin care regimen is facial cleansing and moisturizing. Read More

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http://dx.doi.org/10.1016/j.det.2018.07.001DOI Listing
January 2019

Contact Dermatitis to Cosmetics.

Authors:
Matthew J Zirwas

Clin Rev Allergy Immunol 2018 Nov 12. Epub 2018 Nov 12.

Ohio University, 2359 E Main St., Columbus, OH, 43209, USA.

Allergic contact dermatitis (ACD) to cosmetics is extremely common-probably the most common reason patients present for patch testing. The diagnosis should initially be suspected based on the patient history and the distribution of the dermatitis. Once the diagnosis is suspected, empiric recommendations for low allergenicity products should be implemented until patch testing is performed. Read More

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http://dx.doi.org/10.1007/s12016-018-8717-9DOI Listing
November 2018
9 Reads

Important risk factors for the development of food allergy and potential options for prevention.

Expert Rev Clin Immunol 2018 Nov 9:1-6. Epub 2018 Nov 9.

a Murdoch Children's Research Institute , Parkville , Australia.

Introduction: Food allergy currently affects up to 10% of infants. Identification and implementation of effective food allergy prevention strategies is thus imperative. Areas covered: We focus on five food allergy risk factors/prevention strategies which have been or are currently being tested in randomized controlled trials: (1) timely introduction of allergenic foods into the infant diet; (2) maternal diet and consumption of allergenic foods during pregnancy and breastfeeding; (3) infant skin barrier and the role of moisturizers in early life; (4) infant Vitamin D levels and the role of Vitamin D supplementation; and (5) microbial exposure in early life. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1546577DOI Listing
November 2018
2 Reads

Skin hydration is significantly increased by a cream formulated to mimic the skin's own natural moisturizing systems.

Clin Cosmet Investig Dermatol 2018 15;11:491-497. Epub 2018 Oct 15.

Research and Development, Ego Pharmaceuticals Pty Ltd, Braeside, VIC, Australia,

Background: Moisturizers are topical products designed to improve and maintain the skin barrier function and to help prevent dry skin.

Materials And Methods: A new moisturizer (Ceramide cream) was formulated containing ingredients which mimic the skin's own natural moisturizing systems. Corneometry was performed at baseline, 2, 4, 6 and 24 hours following a single application of Ceramide cream to healthy skin, and compared to three reference moisturizers available over-the-counter, and placebo. Read More

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http://dx.doi.org/10.2147/CCID.S177697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197824PMC
October 2018
4 Reads

A clinician's reference guide for the management of atopic dermatitis in Asians.

Asia Pac Allergy 2018 Oct 29;8(4):e41. Epub 2018 Oct 29.

Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: Atopic dermatitis (AD) is a common skin condition among Asians. Recent studies have shown that Asian AD has a unique clinical and immunologic phenotype compared with European/American AD.

Objective: The Asian Academy of Dermatology and Venereology Expert Panel on Atopic Dermatitis developed this reference guide to provide a holistic and evidence-based approach in managing AD among Asians. Read More

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http://dx.doi.org/10.5415/apallergy.2018.8.e41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209602PMC
October 2018
10 Reads

A systematic review of the efficacy and safety of vaginal estrogen products for the treatment of genitourinary syndrome of menopause.

Menopause 2018 Oct 22. Epub 2018 Oct 22.

TherapeuticsMD, Boca Raton, FL.

Objective: We updated a systematic review to evaluate the totality of evidence available for the efficacy and safety of vaginal estrogen products for the treatment of genitourinary syndrome of menopause (GSM) based on published randomized controlled trials.

Methods: We searched the Cochrane Library, Ovid, PubMed, Medline, Embase, and Clinicaltrials.gov for English-language articles from database inception to June 2018. Read More

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http://Insights.ovid.com/crossref?an=00042192-900000000-9747
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http://dx.doi.org/10.1097/GME.0000000000001221DOI Listing
October 2018
5 Reads

Moisturizers: A Comparison Based on Allergens and Economic Value.

Dermatitis 2018 Nov/Dec;29(6):339-344

From the Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY.

Background: The economic burden of cosmetics, such as moisturizers, has been increasing. Despite the high price of some market moisturizers, there have been no studies evaluating the allergenicity of these products.

Objective: The aim of this study was to evaluate the potential allergens within moisturizers based on economic value, by analyzing the substances found in moisturizers available online at the largest drugstore chain-CVS Health (CVS Health, Woonsocket, RI). Read More

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http://dx.doi.org/10.1097/DER.0000000000000413DOI Listing
October 2018
2 Reads

Moisturizers versus Current and Next-Generation Barrier Repair Therapy for the Management of Atopic Dermatitis.

Skin Pharmacol Physiol 2019 18;32(1):1-7. Epub 2018 Oct 18.

We compare here the principal characteristics of over-the-counter moisturizers with physiologic lipid-based barrier repair therapy. Moisturizers are standard ancillary therapy for anti-inflammatory skin disorders, like atopic dermatitis (AD), and can attenuate the emergence of AD, the initial step in the "atopic march." But not all moisturizers are beneficial; some can make skin function worse, and can even induce inflammation, possibly accounting for the frequent occurrence of "sensitive skin" in women. Read More

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http://dx.doi.org/10.1159/000493641DOI Listing
October 2018

Netherton Syndrome: A Case Report and Review of Literature.

Cureus 2018 Jul 30;10(7):e3070. Epub 2018 Jul 30.

Internal Medicine, Icahn School of Medicine at Mount Sinai Queens Hospital Center, New York, USA.

Netherton syndrome (NS) is a rare autosomal recessive disorder characterized by a triad of congenital ichthyosiform erythroderma (CIE) or ichthyosis linearis circumflexa (ILC), hair shaft abnormalities, and atopic diathesis (elevated serum IgE ). We report a case of a two-year-old boy presented with intractable pruritus, scaling, dry skin and generalized eczematous lesions resistant to atopic dermatitis therapy. Netherton syndrome misdiagnosed as atopic dermatitis due to the presence of eczematous skin lesions and allergic problems. Read More

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http://dx.doi.org/10.7759/cureus.3070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166913PMC
July 2018
6 Reads

Advising Women Undergoing Treatment for Breast Cancer: A Narrative Review.

J Altern Complement Med 2018 Sep/Oct;24(9-10):902-909

1 The University of Arizona Center for Integrative Medicine , Tucson, Arizona.

A majority of women undergoing conventional treatment for breast cancer also undertake complementary and integrative approaches. Practitioners knowledgeable about the evidence base behind common integrative approaches can help patients attain improved quality of life, and at times, improved survival. Evidence-based recommendations include the following: a plant-based diet for general health after diagnosis, and carbohydrate restriction for patients with estrogen receptor-positive postmenopausal breast cancer may be prudent. Read More

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http://dx.doi.org/10.1089/acm.2018.0150DOI Listing
October 2018
2 Reads

Clinical and confocal evaluation of avenanthramides-based daily cleansing and emollient cream in pediatric population affected by atopic dermatitis and xerosis.

G Ital Dermatol Venereol 2018 Sep 12. Epub 2018 Sep 12.

Department of Dermatology, Tor Vergata Polyclinic, Rome, Italy -

Background: Xerosis and atopic dermatitis (AD ) are chronic skin conditions that occur in children and adults which can result in scaling, flaking and itching. Risk factors for xerosis include sunlight, friction, low humidity and use of soaps. Xerosis is also a symptom of cutaneous conditions such as psoriasis, dermatitis and ichthyosis. Read More

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https://www.minervamedica.it/index2.php?show=R23Y9999N00A180
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http://dx.doi.org/10.23736/S0392-0488.18.06002-9DOI Listing
September 2018
6 Reads

Sweat is a most efficient natural moisturizer providing protective immunity at points of allergen entry.

Allergol Int 2018 Oct 1;67(4):442-447. Epub 2018 Sep 1.

Department of Dermatology, Kawasaki Medical School, Kurashiki, Japan; Dermatology, Kawasaki Hospital, Okayama, Japan.

Although there is a growing acceptance that sweat could play a detrimental role in various allergic skin diseases, the possibility that sweat is also involved in maintenance of skin hydration and skin-specific immune responses has not been acknowledged. We initially describe physiological role of sweat in both maintaining skin hydration and thermoregulation. The purpose of this article is to provide the reader with objective evidence that sweating is intimately linked to vital stratum corneum barrier function and usefulness of application of moisturizers in clinical care of allergic skin diseases. Read More

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http://dx.doi.org/10.1016/j.alit.2018.07.010DOI Listing
October 2018

An investigator-blinded, randomized, prospective, comparative study of efficacy of four anti-inflammatory and barrier hand moisturizers in patients with chronic hand dermatitis.

Dermatol Ther 2018 09 2;31(5):e12670. Epub 2018 Sep 2.

Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

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http://dx.doi.org/10.1111/dth.12670DOI Listing
September 2018
3 Reads

Diagnosis and Treatment of Genitourinary Syndrome of Menopause.

Nurs Womens Health 2018 Oct 29;22(5):423-430. Epub 2018 Aug 29.

Genitourinary syndrome of menopause (GSM), formerly referred to as vulvovaginal atrophy or atrophic vaginitis, is a common chronic condition that requires a collaborative treatment plan between a health care provider and a woman to relieve symptoms and improve quality of life. Many women are not aware that symptoms can be controlled with treatment. Current treatment options approved for GSM include vaginal moisturizers, lubricants, and hormones. Read More

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http://dx.doi.org/10.1016/j.nwh.2018.07.005DOI Listing
October 2018
3 Reads

In Vivo Determination of Moisturizers Efficacy on Human Skin Hydration by Confocal Raman Spectroscopy.

AAPS PharmSciTech 2018 Oct 22;19(7):3177-3186. Epub 2018 Aug 22.

Biomedical Engineering Innovation Center, Biomedical Vibrational Spectroscopy Group, Universidade Brasil-UNBr, Rua Carolina Fonseca, 235-08230-030, Itaquera, Sao Paulo, Brazil.

This research work deals with in vivo testing of the efficacy of commercial moisturizer products on the hydration of human skin, as there are various in vitro and ex vivo studies questioning their activity. Confocal Raman spectroscopy was used for this purpose of assessing the efficacy of moisturizers on skin hydration mainly owing to its simple, non-invasive, non-destructive, timesaving, and cost-effective nature. Water content and natural moisturizing factor (NMF) of stratum corneum were analyzed and compared using this method at high wavenumber (2500-4000 cm) and fingerprint (400-1800 cm) spectral regions, respectively, as these two parameters are correlated to skin hydration. Read More

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http://dx.doi.org/10.1208/s12249-018-1143-8DOI Listing
October 2018
3 Reads

Current treatment options for postmenopausal vaginal atrophy.

Int J Womens Health 2018 31;10:387-395. Epub 2018 Jul 31.

Institute Clinic of Gynecology, Obstetrics and Neonatology, Faculty of Medicine-University of Barcelona, Hospital Clinic-August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain,

Vulvovaginal atrophy (VVA) is a silent epidemic that affects up to 50%-60% of postmenopausal women who are suffering in silence from this condition. Hormonal changes, especially hypoestrogenism inherent in menopause, are characterized by a variety of symptoms. More than half of menopausal women are concerned about the symptoms of VVA, such as dryness, burning, itching, vaginal discomfort, pain and burning when urinating, dyspareunia, and spotting during intercourse. Read More

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http://dx.doi.org/10.2147/IJWH.S158913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074805PMC
July 2018
9 Reads

Efficacy of a moisturizer containing a pseudo-ceramide and a eucalyptus extract for Japanese patients with mild atopic dermatitis in the summer.

J Cosmet Dermatol 2018 Aug 6. Epub 2018 Aug 6.

Department of Dermatology, Osaka University, Osaka, Japan.

Background: Skin moisturizing is advocated to take care of the skin of patients with atopic dermatitis (AD). However, many patients stop using moisturizers in the summer because of excessive sweating and high humidity.

Objectives: To examine the efficacy of a moisturizing gel containing a pseudo-ceramide and a eucalyptus extract, which enhances epidermal ceramide synthesis of patients with mild AD in the summer. Read More

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http://dx.doi.org/10.1111/jocd.12735DOI Listing
August 2018
2 Reads

Allergic contact dermatitis caused by dexpanthenol-Probably a frequent allergen.

Contact Dermatitis 2018 Nov 16;79(5):276-280. Epub 2018 Jul 16.

Dermatology Department, Centro Hospitalar Universitário de Coimbra, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal.

Background: Panthenol (synonym: dexpanthenol), the alcohol analogue of panthothenic acid, is frequently included in moisturizers, wound-healing agents, and other cosmetics, and has been shown to be responsible for allergic contact dermatitis (ACD).

Objectives: To evaluate the frequency of ACD caused by dexpanthenol, and to characterize reactive patients.

Methods: We retrospectively reviewed the files of patients patch tested between 2009 and 2017 in the Department of Dermatology of the Coimbra's University Hospital and describe patients who reacted to dexpanthenol 5% pet. Read More

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http://dx.doi.org/10.1111/cod.13054DOI Listing
November 2018
11 Reads

Whole genome sequencing and 6-year follow-up of a mother and daughter with frontometaphyseal dysplasia associated with keratitis, xerosis, poikiloderma, and acro-osteolysis: A case report.

Medicine (Baltimore) 2018 Jul;97(28):e11283

Department of Dermatology.

Rationale: Frontometaphyseal dysplasia (FMD) is a dominant X-linked rare disease caused by mutations of FLNA. The distinctive features of FMD include skeletal dysplasia, facial dysmorphism, extremities anomalies, deafness, cleft palate and eye anterior segment anomalies, yet none of the complications, such as acro-osteolysis, keratitis, xerosis or poikiloderma, have been reported in FMD.

Patient Concerns: A 29-year-old mother and her 7-year-old daughter, both presented with congenital glaucoma, craniofacial dysmorphism, xerosis and poikiloderma, were admitted to our hospital in 2011. Read More

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http://Insights.ovid.com/crossref?an=00005792-201807130-0001
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http://dx.doi.org/10.1097/MD.0000000000011283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076188PMC
July 2018
14 Reads
5.720 Impact Factor

What's the story? An analysis of children's books about atopic dermatitis.

Pediatr Dermatol 2018 Sep 9;35(5):607-610. Epub 2018 Jul 9.

Department of Dermatology, University of Virginia Health System, Charlottesville, VA, USA.

Background/objectives: Atopic dermatitis is an inflammatory skin condition with significant disease burden. Bibliotherapy, the use of storybooks to understand an illness, has been proven effective in several pediatric disorders but has not been studied in dermatologic disease. The purpose of this study was to assess the availability of storybooks about atopic dermatitis and analyze them based on adherence to American Academy of Dermatology guidelines for the treatment of atopic dermatitis, readability, author qualifications, cost, and availability. Read More

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http://dx.doi.org/10.1111/pde.13590DOI Listing
September 2018

Laboratory and severity evaluation of pediatric atopic dermatitis and moisturizer response in different phenotypes.

Authors:
S B Batmaz

Allergol Immunopathol (Madr) 2018 Nov - Dec;46(6):571-577. Epub 2018 Jul 4.

Department of Pediatric Allergy and Immunology, Tokat State Hospital, Tokat, Turkey. Electronic address:

Introduction And Objectives: Atopic dermatitis (AD) is an eczematous skin disease. Our aim was to evaluate the clinical and laboratory findings of children with AD and identify the higher responsive group to moisturizers.

Materials And Methods: Total and specific IgE, eosinophil count, prick/patch test results of patients with AD were retrospectively analyzed. Read More

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http://dx.doi.org/10.1016/j.aller.2018.03.007DOI Listing
July 2018
3 Reads

Gabapentin versus dexchlorpheniramine as treatment for uremic pruritus: a randomised controlled trial.

Eur J Dermatol 2018 Aug;28(4):488-495

Department of Dermatology and Radiotherapy, Botucatu Medical School, São Paulo State University (UNESP).

Background: Uremic pruritus is a common symptom in chronic renal failure patients with undefined pathophysiology. Initial treatment involves topical therapy mainly in the form of moisturizers, however, in many cases, this is not sufficient to relieve itching. Systemic adjuvant therapy is therefore necessary, which commonly includes oral antihistamines, with limited success. Read More

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http://dx.doi.org/10.1684/ejd.2018.3356DOI Listing
August 2018
3 Reads

Duration of topical therapy in the maintenance of atopic dermatitis remission in paediatric age.

Minerva Pediatr 2018 Jul 2. Epub 2018 Jul 2.

Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy.

Background: Topical Corticosteroids (TCS) are the first-choice treatment for atopic dermatitis (AD) flares. In literature there are clear advices about the potency, dosage and frequency of application of TCS, but there are no shared indications about duration of the treatment during a flare. The aim of the study is to demonstrate if the use of a steroid cream for less than or 5 days , could be equal or more effective than the application for more than 5 days during a flare episode, in keeping a remission state of DA. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05064-8DOI Listing
July 2018
7 Reads

Atopic dermatitis.

Nat Rev Dis Primers 2018 Jun 21;4(1). Epub 2018 Jun 21.

Paediatric Dermatology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, with a lifetime prevalence of up to 20% and substantial effects on quality of life. AD is characterized by intense itch, recurrent eczematous lesions and a fluctuating course. AD has a strong heritability component and is closely related to and commonly co-occurs with other atopic diseases (such as asthma and allergic rhinitis). Read More

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http://www.nature.com/articles/s41572-018-0001-z
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http://dx.doi.org/10.1038/s41572-018-0001-zDOI Listing
June 2018
4 Reads

Effectiveness of interventions for preventing occupational irritant hand dermatitis: a quantitative systematic review.

JBI Database System Rev Implement Rep 2018 Jun;16(6):1398-1417

The Scottish Centre for Evidence-based Multi-professional Practice: a Joanna Briggs Institute Centre of Excellence.

Objective: The aim of this review was to identify, appraise and synthesize the best available evidence on the effectiveness of moisturizers, barrier creams, protective gloves, skin protection education and complex interventions (a combination of two or more of the interventions listed here) in preventing occupational irritant hand dermatitis (OIHD) in wet workers, comparing each intervention to an alternative intervention or to usual care (workers' regular skin care regimen).

Introduction: The most significant occupational skin problem potentially encountered in wet work occupations is occupational dermatitis. When the skin comes into contact with hazardous substances at work, this can cause occupational dermatitis. Read More

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http://dx.doi.org/10.11124/JBISRIR-2017-003405DOI Listing
June 2018
3 Reads

Priority issues for pressure injury research: An Australian consensus study.

Res Nurs Health 2018 Jun 8. Epub 2018 Jun 8.

Data 61, Commonwealth Scientific and Industrial Research Organisation, Canberra, Australia.

Pressure injuries are a significant health concern in all clinical settings. The current body of research on pressure injuries reported in the literature presents primarily low level evidence. The purpose of the current study was to identify and prioritize pressure injury research issues. Read More

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http://doi.wiley.com/10.1002/nur.21878
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http://dx.doi.org/10.1002/nur.21878DOI Listing
June 2018
1 Read

The Effect of an Anti-Inflammatory Botanical Cleanser/Night Mask Combination on Facial Redness Reduction.

J Drugs Dermatol 2018 Jun;17(6):671-676

Facial redness is a common difficult to control cosmetic problem representing various phases of rosacea. Using anti-inflammatory/antioxidant botanicals in moisturizer formulations is a possible approach to minimizing the erythema. This research utilized a common facial cleanser, but only applied the botanically based moisturizer to one half face to properly assess efficacy. Read More

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June 2018
2 Reads

Atopic Dermatitis: Early Treatment in Children.

Curr Treat Options Allergy 2017 Sep 1;4(3):355-369. Epub 2017 Aug 1.

Department of Pediatrics, National Jewish Health, Denver, CO.

Therapeutic regimens for the treatment and long-term management of AD traditionally had a two-fold objective of decreasing skin inflammation and repairing the defective skin barrier. Essential treatments for AD in children should include topical moisturizers for skin hydration and prevention of flares, topical anti-inflammatory medications (e.g. Read More

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http://dx.doi.org/10.1007/s40521-017-0140-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983898PMC
September 2017
8 Reads

Adolescents' Perspectives on Atopic Dermatitis Treatment-Experiences, Preferences, and Beliefs.

JAMA Dermatol 2018 Jul;154(7):824-827

Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands.

Importance: For a considerable proportion of pediatric patients, atopic dermatitis symptoms persist into adolescence. Previous studies have focused mainly on (parents of) children, whereas little is known about adolescents with atopic dermatitis.

Objective: To explore the beliefs, experiences, and preferences of adolescents with atopic dermatitis toward their treatment. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.1096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128492PMC

Primary role of barrier dysfunction in the pathogenesis of atopic dermatitis.

Authors:
Peter M Elias

Exp Dermatol 2018 Aug;27(8):847-851

Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.

Based upon the efficacy of recently developed biologics, the pathogenesis of atopic dermatitis (AD) is being attributed once again to the prominent inflammation that occurs in this disorder. Yet, molecular genetics has clearly shown that the aetiology of AD can be attributed to mutations in stratum corneum structural proteins that impact epidermal barrier function, while inflammation instead emerges as a downstream consequence of a sustained, barrier-driven cytokine cascade. Although several different mutations that compromise barrier function are associated with AD, all of these mutations compromise either the contents or secretion of epidermal lamellar bodies. Read More

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http://dx.doi.org/10.1111/exd.13693DOI Listing

Beneficial Effects of Antioxidant Furfuryl Palmitate in Non-pharmacologic Treatments (Prescription Emollient Devices, PEDs) for Atopic Dermatitis and Related Skin Disorders.

Dermatol Ther (Heidelb) 2018 Sep 22;8(3):339-347. Epub 2018 May 22.

Dipartimento di Scienze biomediche, chirurgiche e odontoiatriche, Clinica Dermatologica, Università degli Studi di Milano, Milan, Italy.

Introduction: Atopic dermatitis (AD) is a common chronic inflammatory skin disease; it requires long-term treatments focused on symptomatic relief. Current first-line treatments include moisturizers and topical corticosteroids. Recently, topical antioxidants have been added to moisturizer formulations to alleviate mild-to-moderate AD. Read More

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http://dx.doi.org/10.1007/s13555-018-0239-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109026PMC
September 2018

Genitourinary Syndrome of Menopause.

Authors:
Jan L Shifren

Clin Obstet Gynecol 2018 09;61(3):508-516

Midlife Women's Health Center, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, Massachusetts.

Genitourinary syndrome of menopause (GSM) describes a collection of exam findings and bothersome symptoms associated with estrogen deficiency involving changes to the labia, introitus, clitoris, vagina, urethra, and bladder. Vulvovaginal atrophy is a component of GSM. GSM is a highly prevalent medical condition with adverse effects on the health and quality of life of midlife women. Read More

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http://Insights.ovid.com/crossref?an=00003081-900000000-9960
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http://dx.doi.org/10.1097/GRF.0000000000000380DOI Listing
September 2018
5 Reads

Bevacizumab for Epistaxis in Hereditary Hemorrhagic Telangiectasia: An Evidence-based Review.

Am J Rhinol Allergy 2018 Jul 10;32(4):258-268. Epub 2018 May 10.

4 Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.

Objective Epistaxis is a primary complaint in 90% to 96% of patients with hereditary hemorrhagic telangiectasia (HHT). Numerous surgical and medical treatments aim to decrease the frequency and severity of epistaxis in this patient population. Bevacizumab is a recombinant, humanized monoclonal antibody to vascular endothelial growth factor, an angiogenic factor elevated in HHT. Read More

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http://dx.doi.org/10.1177/1945892418768588DOI Listing

Influences on use of hand moisturizers in nurses.

Occup Med (Lond) 2018 06;68(5):340-342

Occupational Health Department, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK.

Background: Nurses are at high risk of hand dermatitis. Regular hand moisturizing can prevent dermatitis, but nurses' use of hand moisturizers is suboptimal.

Aims: To establish (i) what beliefs about hand dermatitis and hand moisturizer use are associated with hand moisturizer use by nurses at home and at work and (ii) if hand moisturizer use behaviours in nurses are associated with the prevalence of hand dermatitis. Read More

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http://dx.doi.org/10.1093/occmed/kqy068DOI Listing
June 2018
2 Reads

Genitourinary syndrome of menopause: Common problem, effective treatments.

Cleve Clin J Med 2018 May;85(5):390-398

Professor of Obstetrics and Gynecology and Professor of Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

After menopause, about half of all women experience genital, sexual, and urinary symptoms associated with decreases in estrogen, termed genitourinary syndrome of menopause. First-line therapies are nonhormonal vaginal lubricants and moisturizers. For persistent symptoms, prescription estrogen in cream and ring formulations is effective. Read More

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http://dx.doi.org/10.3949/ccjm.85a.15081DOI Listing
May 2018
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Emollient treatment of atopic dermatitis: latest evidence and clinical considerations.

Drugs Context 2018 17;7:212530. Epub 2018 Apr 17.

Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong.

Aim: To review current classes of emollients in the market, their clinical efficacy in atopic dermatitis (AD) and considerations for choice of an emollient.

Methods: PubMed Clinical Queries under Clinical Study Categories (with Category limited to Therapy and Scope limited to Narrow) and Systematic Reviews were used as the search engine. Keywords of 'emollient or moisturizer' and 'atopic dermatitis' were used. Read More

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http://dx.doi.org/10.7573/dic.212530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908267PMC

No. 358-Intravaginal Laser for Genitourinary Syndrome of Menopause and Stress Urinary Incontinence.

J Obstet Gynaecol Can 2018 Apr;40(4):503-511

Montréal, QC.

Objective: This technical bulletin reviews the evidence relating to risks and benefits of using intravaginal laser technology in the management of genitourinary syndrome of menopause and stress urinary incontinence.

Intended Users: Gynaecologists, urogynaecologists, urologists, and other health care professionals who assess, counsel, and provide care for women with genitourinary syndrome of menopause and stress urinary incontinence.

Target Population: Adult women with genitourinary syndrome of menopause and stress urinary incontinence seeking complementary or alternative treatment options to topical estrogen, non-hormonal vaginal moisturizers, physiotherapy, intravaginal devices, and surgery. Read More

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http://dx.doi.org/10.1016/j.jogc.2017.11.040DOI Listing

Significance of Skin Barrier Dysfunction in Atopic Dermatitis.

Allergy Asthma Immunol Res 2018 May;10(3):207-215

Department of Pediatrics, National Jewish Health, Denver, CO, USA.

The epidermis contains epithelial cells, immune cells, and microbes which provides a physical and functional barrier to the protection of human skin. It plays critical roles in preventing environmental allergen penetration into the human body and responsing to microbial pathogens. Atopic dermatitis (AD) is the most common, complex chronic inflammatory skin disease. Read More

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http://dx.doi.org/10.4168/aair.2018.10.3.207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911439PMC
May 2018
3.080 Impact Factor

Dermatologic Toxicity Occurring During Anti-EGFR Monoclonal Inhibitor Therapy in Patients With Metastatic Colorectal Cancer: A Systematic Review.

Clin Colorectal Cancer 2018 06 13;17(2):85-96. Epub 2017 Dec 13.

Jefferson University Hospitals, Philadelphia, PA.

Monoclonal antibody inhibitors of the epidermal growth factor receptor (EGFR) have been shown to improve outcomes for patients with metastatic colorectal cancer (mCRC) without RAS gene mutations. However, treatment with anti-EGFR agents can be associated with toxicities of the skin, nails, hair, and eyes. Because these dermatologic toxicities can result in treatment discontinuation and affect patient quality of life, their management is an important focus when administering anti-EGFR monoclonal antibodies. Read More

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http://dx.doi.org/10.1016/j.clcc.2017.12.004DOI Listing
June 2018
7 Reads

Vaginal health and hygiene practices and product use in Canada: a national cross-sectional survey.

BMC Womens Health 2018 03 23;18(1):52. Epub 2018 Mar 23.

Department of Psychology, University of Guelph, 50 Stone Road E, Guelph, Ontario, N1G 2W1, Canada.

Background: The vaginal microbiome influences quality of life and health. The composition of vaginal microbiota can be affected by various health behaviors, such as vaginal douching. The purpose of this study was to examine the types and prevalence of diverse vaginal/genital health and hygiene behaviors among participants living in Canada and to examine associations between behavioral practices and adverse gynecological health conditions. Read More

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http://dx.doi.org/10.1186/s12905-018-0543-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865287PMC
March 2018
4 Reads

Deriving a water quality guideline for protection of aquatic communities exposed to triclosan in the Canadian environment.

Integr Environ Assess Manag 2018 Jul 24;14(4):437-441. Epub 2018 Apr 24.

Colgate-Palmolive Company, New York, New York, USA.

Triclosan is an antibacterial and antifungal chemical used in a variety of consumer products, including soaps, detergents, moisturizers, and cosmetics. Aquatic ecosystems may be exposed to triclosan following the release of remaining residues in wastewater effluents and biosolids. In December 2017, Environment and Climate Change Canada (ECCC) released a federal environmental quality guideline (FEQG) report that contained a federal water quality guideline (FWQG) for triclosan. Read More

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http://dx.doi.org/10.1002/ieam.4042DOI Listing
July 2018
11 Reads

Contact allergy to moisturizers in Finland: the tale of the lurking tube in the medicine cupboard.

Authors:
Nicolas Kluger

Contact Dermatitis 2018 Apr;78(4):289-290

Dermatology, Venereology, Allergology, Skin and Allergies Hospital, University of Helsinki and Helsinki University Central Hospital, 00029, Helsinki, Finland.

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http://dx.doi.org/10.1111/cod.12927DOI Listing
April 2018
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Beyond the physico-chemical barrier: Glycerol and xylitol markedly yet differentially alter gene expression profiles and modify signalling pathways in human epidermal keratinocytes.

Exp Dermatol 2018 03;27(3):280-284

Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Polyols (e.g. glycerol, xylitol) are implicated as moisturizers of the skin and other epithelial tissues. Read More

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http://doi.wiley.com/10.1111/exd.13493
Publisher Site
http://dx.doi.org/10.1111/exd.13493DOI Listing
March 2018
4 Reads

Parental confusion may result when primary health care professionals show heterogeneity in their knowledge, attitudes, and perceptions regarding infant nutrition, food allergy, and atopic dermatitis.

Allergol Immunopathol (Madr) 2018 Jul - Aug;46(4):326-333. Epub 2018 Feb 26.

PEDEGO Research Unit and MRC Oulu, University of Oulu and Oulu University Hospital, P.O. Box 5000, FIN 90014 Oulu, Finland; Biomedicine Research Unit, Medical Microbiology and Immunology, University of Oulu, P.O. Box 5000, FIN 90014 Oulu, Finland.

Introduction And Objectives: Whether the guidelines on infant nutrition, food allergy and atopic dermatitis confer real health benefits in practice at the population level has not been deeply studied. We aimed here to characterize the knowledge, attitudes, and perceptions regarding these issues among primary health care professionals. In addition, we surveyed available parent-reported information sources and the incidence of food-related symptoms, dietary restrictions, food allergy, and atopic dermatitis among one-year-old children in the general population. Read More

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http://dx.doi.org/10.1016/j.aller.2017.09.017DOI Listing
October 2018
13 Reads

Quality of Life, Behaviour and Attitudes towards Actinic Keratosis in Spain: The PIQA Study.

Actas Dermosifiliogr 2018 May 22;109(4):331-339. Epub 2018 Feb 22.

Instituto Valenciano de Oncología, Valencia, España. Electronic address:

Objective: This study was aimed to examine patients' knowledge, behaviours and attitudes regarding actinic keratosis (AK) lesions and the impact of the disease on patients' quality of life (QoL).

Methods: Observational study of patients with AK lesions in Spain. QoL was evaluated with the validated version of Spanish AKQoL questionnaire. Read More

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http://dx.doi.org/10.1016/j.ad.2018.01.004DOI Listing

A Nonsteroidal Novel Formulation Targeting Inflammatory and Pruritus-Related Mediators Modulates Experimental Allergic Contact Dermatitis.

Dermatol Ther (Heidelb) 2018 Mar 16;8(1):111-126. Epub 2018 Feb 16.

Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Introduction: A major clinical challenge in treating allergic contact dermatitis (ACD) is that the first line of treatment is based on the use of corticosteroids. In this study, we aimed to develop a formulation that is devoid of steroids.

Methods: We used mouse ears treated with dinitrofluorobenzene (DNFB) to induce ACD. Read More

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http://dx.doi.org/10.1007/s13555-018-0223-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825328PMC
March 2018
5 Reads