Search Our Scientific Publications & Authors

Curr Pediatr Rev 2019 Apr 15. Epub 2019 Apr 15.

Department of Paediatrics, The Chinese University of Hong Kong, Shatin. Hong Kong.

Aim: To describe the methodology in studying patient's acceptability and efficacy of an ectoin containing emollient for atopic dermatitis (AD) Methods: We described the methodology that we used in studying emollients and moisturizers, and patient acceptability of a group of AD patients before and following usage of an ectoin-containing proprietary emollient. These data were also compared with other emollients that we previously reported.

Results: 30 subjects (50% Male, Mean (SD) age: 9. Read More

J Clin Med 2019 Apr 2;8(4). Epub 2019 Apr 2.

Department of Dermatology, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.

Atopic dermatitis (AD) is a long-standing inflammatory skin disease that is highly prevalent worldwide. Multiple factors contribute to AD, with genetics as well as the environment affecting disease development. Although AD shows signs of skin barrier defect and immunological deviation, the mechanism underlying AD is not well understood, and AD treatment is often very difficult. Read More

J Cosmet Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts.

Background: Gender-related price inequalities for over-the-counter dermatologic products such as shampoos and conditioners, razors, deodorants, and lotions remain prevalent in the marketplace. This trend has also been found to apply to topical minoxidil, a common treatment for male and female pattern hair loss.

Objective: We sought to identify the gender-related price discrepancies of facial moisturizers, which are routinely recommended by dermatologists. Read More

Skin Res Technol 2019 Apr 1. Epub 2019 Apr 1.

Department of Chemistry, Rutgers University, Newark, New Jersey.

Background: Skin hydration is essential for maintaining stratum corneum (SC) flexibility and facilitating maturation events. Moisturizers contain multiple ingredients to maintain and improve skin hydration although a complete understanding of hydration mechanisms is lacking. The ability to differentiate the source of the hydration (water from the environment or deeper skin regions) upon application of product will aid in designing more efficacious formulations. Read More

J Am Board Fam Med 2019 Mar-Apr;32(2):191-200

From Department of Dermatology, Oregon Health and Science University, Portland (JA, JH, ST, ELS); Oregon Rural Practice-based Research Network, Oregon Health and Science University, Portland (SD, LJF, LM, KB, KD); Public Health and Preventive Medicine, Oregon Health and Science University, Portland (KR, KEZ, JL); Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland (JM, CM); High Plains Research Network, University of Colorado, Denver (DEN, LZ); Iowa Research Network, University of Iowa, Iowa City (BL, JD); Wisconsin Research and Education Network, University of Wisconsin, Madison (DH); Primary Care Research Consortium, Duke University, Durham, North Carolina (RD); Centre of Evidence-Based Dermatology, University of Nottingham, England (HCW, JRC); Division of General Pediatrics, Oregon Health and Science University, Portland (KEZ); Patient Advocate (KH, MG); National Eczema Association, San Rafael, CA (JB); Mid-Columbia Medical Center, The Dalles, OR (FK); Treasure Valley Pediatric Clinic, Ontario (SD); Winding Waters Clinic, Enterprise (KS); National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Health, Bethesda, MD (RC).

Background: Little is known about the burden of atopic dermatitis (AD) encountered in US primary care practices and the frequency and type of skin care practices routinely used in children.

Objective: To estimate the prevalence of AD in children 0 to 5 years attending primary care practices in the United States and to describe routine skin care practices used in this population.

Design: A cross-sectional survey study of a convenience sample of children under the age of 5 attending primary care practices for any reason. Read More

Dermatitis 2019 Mar/Apr;30(2):142-149

From the Unit of Occupational Medicine, University of Trieste, Italy.

Background: During work, hairdressers are exposed to several hazardous agents that can cause skin and respiratory symptoms. Because few data are available for long-term follow-up, and none are from Italy, the aim of our study was to investigate occupational symptoms in hairdressers after a 10-year follow-up.

Methods: Work-related skin and respiratory symptoms were investigated in 2006 and 2016 by means of a standardized questionnaire and medical examination. Read More

Dermatol Ther (Heidelb) 2019 Feb 15. Epub 2019 Feb 15.

Population Health Sciences, University of Bristol, Bristol, UK.

Atopic dermatitis/eczema is a chronic inflammatory skin condition, and emollients are the first-line treatment. Despite their widespread use, there is uncertainty about the frequency and type of adverse events associated with different emollients. We conducted a restricted review of published data on adverse events associated with emollient use in eczema. Read More

J Am Podiatr Med Assoc 2018 Nov;108(6):458-465

Background:: Xerosis (dryness) of the foot is commonly encountered in clinical care and can lead to discomfort, pain, and predisposition to infection. Many moisturizing products are available, with little definitive research to recommend any particular formulation.

Methods:: We compared two commonly prescribed moisturizing products from different ends of the price spectrum (sorbolene and 25% urea cream) for their effectiveness in reducing xerosis signs using the Specified Symptom Sum Score. Read More

Vet Med Sci 2019 Feb 11. Epub 2019 Feb 11.

U955 - IMRB, Team 10 - Biology of the neuromuscular system, Inserm, UPEC, Ecole nationale vétérinaire d'Alfort, Maisons-Alfort, France.

Ichthyoses represent a heterogeneous group of hereditary cornification disorders characterized by generalized scaling of the skin. An autosomal recessive congenital ichthyosis (ARCI) has been described in American Bulldogs and is caused by a variant in the NIPAL4 gene encoding for the ICHTHYIN protein. So far, this variant has not been described in other breeds. Read More

Vet Dermatol 2019 Apr 6;30(2):155-e46. Epub 2019 Feb 6.

Centre for Clinical Veterinary Medicine, LMU Munich, Veterinaerstraße 13, 80539, Muenchen, Germany.

Background: Topical application of polyunsaturated fatty acids (PUFAs) has shown satisfactory results in dogs and humans with allergic skin diseases. Urea and glycolic acid act as keratolytics and moisturizers. Culicoides hypersensitivity is the most common equine hypersensitivity disorder and only limited treatment options exist. Read More

J Drugs Dermatol 2019 01;18(1s):s89-95

Moisturizers provide significant benefit in dermatology – as adjuvant therapy for many clinical conditions, as a key player in anti-aging regimens, and as a core component in maintaining healthy skin barrier function. Although they have been a mainstay for decades, lotions and creams are no longer formulated with a one-size-fits-all approach, where thickness was the primary cue for efficacy. In fact, moisturizer design today has become an art as well as a science. Read More

J Drugs Dermatol 2019 01;18(1):80-85

Introduction: The skin of subjects with dry, flaking, and/or scaling conditions is characterized by decreased water and skin lipids content among other findings. It is well understood that daily use of gentle cleansers and moisturizers may help to restore and maintain an optimal skin barrier function. A cohort study of patients with dry skin was developed to evaluate efficacy of daily use of a ceramide containing cleanser and cream that also has salicylic acid. Read More

J Drugs Dermatol 2019 01;18(1):28-31

Background: Moisturizers create the illusion of smooth, soft skin by placing a temporary film over the skin surface or by imparting a transient hydration benefit that does not clinically improve the quality or appearance of skin. Objective: The objective of this 8-week study was to assess the clinically relevant effects of a 3-step facial treatment program to improve the multiple qualities of photoaged skin. Methods: Thirty-five female subjects were evaluated at baseline and after 2, 4, and 8 weeks. Read More

Am J Clin Dermatol 2019 Jan 23. Epub 2019 Jan 23.

Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157-1071, USA.

Background: Topical retinoids are a first-line treatment for acne vulgaris.

Objective: This systematic review aims to evaluate the efficacy, safety, and tolerability of topical retinoids approved in the United States for the treatment of acne vulgaris.

Methods: A PubMed and Embase search was conducted using the search terms 'adapalene,' 'tretinoin,' 'tazarotene,' and 'acne vulgaris. Read More

J Dtsch Dermatol Ges 2019 03 22;17(3):319-320. Epub 2019 Jan 22.

Outpatient Clinic of Dermatology, Triemli Hospital, Zurich, Switzerland.

Contact Dermatitis 2019 Jan 16. Epub 2019 Jan 16.

Department of Dermatology, Amsterdam UMC (De Boelelaan), Amsterdam, The Netherlands.

Background: Healthcare workers (HCWs) are at risk of developing hand dermatitis (HD). Guidelines recommend moisturizers to prevent HD, but in practice their effectiveness has been poorly investigated.

Objectives: To assess whether an intervention aimed at improving skin care leads to a reduction in HD severity. Read More

J Cosmet Dermatol 2018 Nov 22. Epub 2018 Nov 22.

Department of Dermatology, McGaw Medical Center of Northwestern University, Chicago, Illinois.

Background: There have been several recent controversies surrounding cosmetic products that have impacted health. Dermatologists are often the first to encounter these issues, and recalls are one metric of a safety profile of cosmetics and their impact on health.

Objective: To analyze all recalls of cosmetic and personal care products from 2002 to 2016. Read More

Acta Derm Venereol 2019 Mar;99(3):263-267

Department of Dermatology and Allergy, Technical University Munich, Biedersteinerstrasse 29, DE-80802 Munich, Germany.

Atopic eczema (AE) is one of the most common non-communicable inflammatory skin diseases, and has a huge socioeconomic impact. Studies on the everyday economic impact of AE on patients, however, are limited. To estimate the annual extra out-of-pocket spending due to AE among patients in Europe, a cross-sectional study using computer-assisted phone interviewing of patients with AE was performed in 9 European countries. Read More

Dermatol Clin 2019 Jan 1;37(1):107-115. Epub 2018 Nov 1.

Dermatology Consulting Services, PLLC, 2444 North Main Street, High Point, NC 27262, USA. Electronic address:

Cosmeceuticals are cosmetics that promise to deliver physiologically relevant benefits without the incorporation of prescription drugs. To entice consumers to purchase these premium priced products, a story must be told of how the cosmeceutical delivers on these appearance improvement promises. The backbone of any cosmeceutical skin care regimen is facial cleansing and moisturizing. Read More

Clin Rev Allergy Immunol 2019 Feb;56(1):119-128

Ohio University, 2359 E Main St., Columbus, OH, 43209, USA.

Allergic contact dermatitis (ACD) to cosmetics is extremely common-probably the most common reason patients present for patch testing. The diagnosis should initially be suspected based on the patient history and the distribution of the dermatitis. Once the diagnosis is suspected, empiric recommendations for low allergenicity products should be implemented until patch testing is performed. Read More

Expert Rev Clin Immunol 2018 Nov 9:1-6. Epub 2018 Nov 9.

a Murdoch Children's Research Institute , Parkville , Australia.

Introduction: Food allergy currently affects up to 10% of infants. Identification and implementation of effective food allergy prevention strategies is thus imperative. Areas covered: We focus on five food allergy risk factors/prevention strategies which have been or are currently being tested in randomized controlled trials: (1) timely introduction of allergenic foods into the infant diet; (2) maternal diet and consumption of allergenic foods during pregnancy and breastfeeding; (3) infant skin barrier and the role of moisturizers in early life; (4) infant Vitamin D levels and the role of Vitamin D supplementation; and (5) microbial exposure in early life. Read More

Clin Cosmet Investig Dermatol 2018 15;11:491-497. Epub 2018 Oct 15.

Research and Development, Ego Pharmaceuticals Pty Ltd, Braeside, VIC, Australia,

Background: Moisturizers are topical products designed to improve and maintain the skin barrier function and to help prevent dry skin.

Materials And Methods: A new moisturizer (Ceramide cream) was formulated containing ingredients which mimic the skin's own natural moisturizing systems. Corneometry was performed at baseline, 2, 4, 6 and 24 hours following a single application of Ceramide cream to healthy skin, and compared to three reference moisturizers available over-the-counter, and placebo. Read More

Asia Pac Allergy 2018 Oct 29;8(4):e41. Epub 2018 Oct 29.

Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: Atopic dermatitis (AD) is a common skin condition among Asians. Recent studies have shown that Asian AD has a unique clinical and immunologic phenotype compared with European/American AD.

Objective: The Asian Academy of Dermatology and Venereology Expert Panel on Atopic Dermatitis developed this reference guide to provide a holistic and evidence-based approach in managing AD among Asians. Read More

Menopause 2019 Apr;26(4):431-453

TherapeuticsMD, Boca Raton, FL.

Objective: We updated a systematic review to evaluate the totality of evidence available for the efficacy and safety of vaginal estrogen products for the treatment of genitourinary syndrome of menopause (GSM) based on published randomized controlled trials.

Methods: We searched the Cochrane Library, Ovid, PubMed, Medline, Embase, and Clinicaltrials.gov for English-language articles from database inception to June 2018. Read More

Dermatitis 2018 Nov/Dec;29(6):339-344

From the Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY.

Background: The economic burden of cosmetics, such as moisturizers, has been increasing. Despite the high price of some market moisturizers, there have been no studies evaluating the allergenicity of these products.

Objective: The aim of this study was to evaluate the potential allergens within moisturizers based on economic value, by analyzing the substances found in moisturizers available online at the largest drugstore chain-CVS Health (CVS Health, Woonsocket, RI). Read More

Skin Pharmacol Physiol 2019 18;32(1):1-7. Epub 2018 Oct 18.

We compare here the principal characteristics of over-the-counter moisturizers with physiologic lipid-based barrier repair therapy. Moisturizers are standard ancillary therapy for anti-inflammatory skin disorders, like atopic dermatitis (AD), and can attenuate the emergence of AD, the initial step in the "atopic march." But not all moisturizers are beneficial; some can make skin function worse, and can even induce inflammation, possibly accounting for the frequent occurrence of "sensitive skin" in women. Read More

Cureus 2018 Jul 30;10(7):e3070. Epub 2018 Jul 30.

Internal Medicine, Icahn School of Medicine at Mount Sinai Queens Hospital Center, New York, USA.

Netherton syndrome (NS) is a rare autosomal recessive disorder characterized by a triad of congenital ichthyosiform erythroderma (CIE) or ichthyosis linearis circumflexa (ILC), hair shaft abnormalities, and atopic diathesis (elevated serum IgE ). We report a case of a two-year-old boy presented with intractable pruritus, scaling, dry skin and generalized eczematous lesions resistant to atopic dermatitis therapy. Netherton syndrome misdiagnosed as atopic dermatitis due to the presence of eczematous skin lesions and allergic problems. Read More

J Altern Complement Med 2018 Sep/Oct;24(9-10):902-909

1 The University of Arizona Center for Integrative Medicine , Tucson, Arizona.

A majority of women undergoing conventional treatment for breast cancer also undertake complementary and integrative approaches. Practitioners knowledgeable about the evidence base behind common integrative approaches can help patients attain improved quality of life, and at times, improved survival. Evidence-based recommendations include the following: a plant-based diet for general health after diagnosis, and carbohydrate restriction for patients with estrogen receptor-positive postmenopausal breast cancer may be prudent. Read More

G Ital Dermatol Venereol 2019 Feb 12;154(1):32-36. Epub 2018 Sep 12.

Department of Dermatology, Tor Vergata Polyclinic, Rome, Italy -

Background: Xerosis and atopic dermatitis (AD) are chronic skin conditions that occur in children and adults which can result in scaling, flaking and itching. Risk factors for xerosis include sunlight, friction, low humidity and use of soaps. Xerosis is also a symptom of cutaneous conditions such as psoriasis, dermatitis and ichthyosis. Read More

Allergol Int 2018 Oct 1;67(4):442-447. Epub 2018 Sep 1.

Department of Dermatology, Kawasaki Medical School, Kurashiki, Japan; Dermatology, Kawasaki Hospital, Okayama, Japan.

Although there is a growing acceptance that sweat could play a detrimental role in various allergic skin diseases, the possibility that sweat is also involved in maintenance of skin hydration and skin-specific immune responses has not been acknowledged. We initially describe physiological role of sweat in both maintaining skin hydration and thermoregulation. The purpose of this article is to provide the reader with objective evidence that sweating is intimately linked to vital stratum corneum barrier function and usefulness of application of moisturizers in clinical care of allergic skin diseases. Read More

Dermatol Ther 2018 09 2;31(5):e12670. Epub 2018 Sep 2.

Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Nurs Womens Health 2018 Oct 29;22(5):423-430. Epub 2018 Aug 29.

Genitourinary syndrome of menopause (GSM), formerly referred to as vulvovaginal atrophy or atrophic vaginitis, is a common chronic condition that requires a collaborative treatment plan between a health care provider and a woman to relieve symptoms and improve quality of life. Many women are not aware that symptoms can be controlled with treatment. Current treatment options approved for GSM include vaginal moisturizers, lubricants, and hormones. Read More

AAPS PharmSciTech 2018 Oct 22;19(7):3177-3186. Epub 2018 Aug 22.

Biomedical Engineering Innovation Center, Biomedical Vibrational Spectroscopy Group, Universidade Brasil-UNBr, Rua Carolina Fonseca, 235-08230-030, Itaquera, Sao Paulo, Brazil.

This research work deals with in vivo testing of the efficacy of commercial moisturizer products on the hydration of human skin, as there are various in vitro and ex vivo studies questioning their activity. Confocal Raman spectroscopy was used for this purpose of assessing the efficacy of moisturizers on skin hydration mainly owing to its simple, non-invasive, non-destructive, timesaving, and cost-effective nature. Water content and natural moisturizing factor (NMF) of stratum corneum were analyzed and compared using this method at high wavenumber (2500-4000 cm) and fingerprint (400-1800 cm) spectral regions, respectively, as these two parameters are correlated to skin hydration. Read More

Int J Womens Health 2018 31;10:387-395. Epub 2018 Jul 31.

Institute Clinic of Gynecology, Obstetrics and Neonatology, Faculty of Medicine-University of Barcelona, Hospital Clinic-August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain,

Vulvovaginal atrophy (VVA) is a silent epidemic that affects up to 50%-60% of postmenopausal women who are suffering in silence from this condition. Hormonal changes, especially hypoestrogenism inherent in menopause, are characterized by a variety of symptoms. More than half of menopausal women are concerned about the symptoms of VVA, such as dryness, burning, itching, vaginal discomfort, pain and burning when urinating, dyspareunia, and spotting during intercourse. Read More

J Cosmet Dermatol 2018 Aug 6. Epub 2018 Aug 6.

Department of Dermatology, Osaka University, Osaka, Japan.

Background: Skin moisturizing is advocated to take care of the skin of patients with atopic dermatitis (AD). However, many patients stop using moisturizers in the summer because of excessive sweating and high humidity.

Objectives: To examine the efficacy of a moisturizing gel containing a pseudo-ceramide and a eucalyptus extract, which enhances epidermal ceramide synthesis of patients with mild AD in the summer. Read More

Contact Dermatitis 2018 Nov 16;79(5):276-280. Epub 2018 Jul 16.

Dermatology Department, Centro Hospitalar Universitário de Coimbra, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal.

Background: Panthenol (synonym: dexpanthenol), the alcohol analogue of panthothenic acid, is frequently included in moisturizers, wound-healing agents, and other cosmetics, and has been shown to be responsible for allergic contact dermatitis (ACD).

Objectives: To evaluate the frequency of ACD caused by dexpanthenol, and to characterize reactive patients.

Methods: We retrospectively reviewed the files of patients patch tested between 2009 and 2017 in the Department of Dermatology of the Coimbra's University Hospital and describe patients who reacted to dexpanthenol 5% pet. Read More

Medicine (Baltimore) 2018 Jul;97(28):e11283

Department of Dermatology.

Rationale: Frontometaphyseal dysplasia (FMD) is a dominant X-linked rare disease caused by mutations of FLNA. The distinctive features of FMD include skeletal dysplasia, facial dysmorphism, extremities anomalies, deafness, cleft palate and eye anterior segment anomalies, yet none of the complications, such as acro-osteolysis, keratitis, xerosis or poikiloderma, have been reported in FMD.

Patient Concerns: A 29-year-old mother and her 7-year-old daughter, both presented with congenital glaucoma, craniofacial dysmorphism, xerosis and poikiloderma, were admitted to our hospital in 2011. Read More

Pediatr Dermatol 2018 Sep 9;35(5):607-610. Epub 2018 Jul 9.

Department of Dermatology, University of Virginia Health System, Charlottesville, VA, USA.

Background/objectives: Atopic dermatitis is an inflammatory skin condition with significant disease burden. Bibliotherapy, the use of storybooks to understand an illness, has been proven effective in several pediatric disorders but has not been studied in dermatologic disease. The purpose of this study was to assess the availability of storybooks about atopic dermatitis and analyze them based on adherence to American Academy of Dermatology guidelines for the treatment of atopic dermatitis, readability, author qualifications, cost, and availability. Read More

Allergol Immunopathol (Madr) 2018 Nov - Dec;46(6):571-577. Epub 2018 Jul 4.

Department of Pediatric Allergy and Immunology, Tokat State Hospital, Tokat, Turkey. Electronic address:

Introduction And Objectives: Atopic dermatitis (AD) is an eczematous skin disease. Our aim was to evaluate the clinical and laboratory findings of children with AD and identify the higher responsive group to moisturizers.

Materials And Methods: Total and specific IgE, eosinophil count, prick/patch test results of patients with AD were retrospectively analyzed. Read More

Eur J Dermatol 2018 Aug;28(4):488-495

Department of Dermatology and Radiotherapy, Botucatu Medical School, São Paulo State University (UNESP).

Background: Uremic pruritus is a common symptom in chronic renal failure patients with undefined pathophysiology. Initial treatment involves topical therapy mainly in the form of moisturizers, however, in many cases, this is not sufficient to relieve itching. Systemic adjuvant therapy is therefore necessary, which commonly includes oral antihistamines, with limited success. Read More

Minerva Pediatr 2018 Jul 2. Epub 2018 Jul 2.

Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy.

Background: Topical Corticosteroids (TCS) are the first-choice treatment for atopic dermatitis (AD) flares. In literature there are clear advices about the potency, dosage and frequency of application of TCS, but there are no shared indications about duration of the treatment during a flare. The aim of the study is to demonstrate if the use of a steroid cream for less than or 5 days , could be equal or more effective than the application for more than 5 days during a flare episode, in keeping a remission state of DA. Read More

Nat Rev Dis Primers 2018 Jun 21;4(1). Epub 2018 Jun 21.

Paediatric Dermatology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, with a lifetime prevalence of up to 20% and substantial effects on quality of life. AD is characterized by intense itch, recurrent eczematous lesions and a fluctuating course. AD has a strong heritability component and is closely related to and commonly co-occurs with other atopic diseases (such as asthma and allergic rhinitis). Read More

JBI Database System Rev Implement Rep 2018 Jun;16(6):1398-1417

The Scottish Centre for Evidence-based Multi-professional Practice: a Joanna Briggs Institute Centre of Excellence.

Objective: The aim of this review was to identify, appraise and synthesize the best available evidence on the effectiveness of moisturizers, barrier creams, protective gloves, skin protection education and complex interventions (a combination of two or more of the interventions listed here) in preventing occupational irritant hand dermatitis (OIHD) in wet workers, comparing each intervention to an alternative intervention or to usual care (workers' regular skin care regimen).

Introduction: The most significant occupational skin problem potentially encountered in wet work occupations is occupational dermatitis. When the skin comes into contact with hazardous substances at work, this can cause occupational dermatitis. Read More

Res Nurs Health 2018 Jun 8. Epub 2018 Jun 8.

Data 61, Commonwealth Scientific and Industrial Research Organisation, Canberra, Australia.

Pressure injuries are a significant health concern in all clinical settings. The current body of research on pressure injuries reported in the literature presents primarily low level evidence. The purpose of the current study was to identify and prioritize pressure injury research issues. Read More

J Drugs Dermatol 2018 Jun;17(6):671-676

Facial redness is a common difficult to control cosmetic problem representing various phases of rosacea. Using anti-inflammatory/antioxidant botanicals in moisturizer formulations is a possible approach to minimizing the erythema. This research utilized a common facial cleanser, but only applied the botanically based moisturizer to one half face to properly assess efficacy. Read More

Curr Treat Options Allergy 2017 Sep 1;4(3):355-369. Epub 2017 Aug 1.

Department of Pediatrics, National Jewish Health, Denver, CO.

Therapeutic regimens for the treatment and long-term management of AD traditionally had a two-fold objective of decreasing skin inflammation and repairing the defective skin barrier. Essential treatments for AD in children should include topical moisturizers for skin hydration and prevention of flares, topical anti-inflammatory medications (e.g. Read More

JAMA Dermatol 2018 Jul;154(7):824-827

Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands.

Importance: For a considerable proportion of pediatric patients, atopic dermatitis symptoms persist into adolescence. Previous studies have focused mainly on (parents of) children, whereas little is known about adolescents with atopic dermatitis.

Objective: To explore the beliefs, experiences, and preferences of adolescents with atopic dermatitis toward their treatment. Read More

Exp Dermatol 2018 08;27(8):847-851

Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.

Based upon the efficacy of recently developed biologics, the pathogenesis of atopic dermatitis (AD) is being attributed once again to the prominent inflammation that occurs in this disorder. Yet, molecular genetics has clearly shown that the aetiology of AD can be attributed to mutations in stratum corneum structural proteins that impact epidermal barrier function, while inflammation instead emerges as a downstream consequence of a sustained, barrier-driven cytokine cascade. Although several different mutations that compromise barrier function are associated with AD, all of these mutations compromise either the contents or secretion of epidermal lamellar bodies. Read More