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Front Allergy 2022 4;3:862620. Epub 2022 Apr 4.

Allergy Center, National Center for Child Health and Development, Tokyo, Japan.

Background: Atopic dermatitis (AD) is a chronic and inflammatory skin disease that causes health-related burdens associated with pruritus and poor quality of life. Our previous study demonstrated that moisturizer (2e) application has a primary preventive effect on AD. However, this effect was not observed in recent randomized control trials. Read More

Medicina (Kaunas) 2022 Jun 6;58(6). Epub 2022 Jun 6.

Obstetrics and Gynecology Unit, IRCCS San Raffaele Hospital, Vita-Salute University, 20132 Milan, Italy.

Vulvovaginal atrophy (VVA) is a chronic progressive disease involving the female genital apparatus and lower urinary tract. This condition is related to hypoestrogenism consequent to menopause onset but is also due to the hormonal decrease after adjuvant therapy for patients affected by breast cancer. Considering the high prevalence of VVA and the expected growth of this condition due to the increase in the average age of the female population, it is easy to understand its significant social impact. Read More

Front Nutr 2022 2;9:895192. Epub 2022 Jun 2.

Dermatology Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Background: The dietary supplement industry offers many oral cosmetics that purportedly assist in skin moisturization often with unclear evidence supporting efficacy and safety. To update the accessible proofs pertaining to the safety and effectiveness of oral dietary supplements to facilitate skin moisturizing via an all-around review and meta-analysis.

Methods: Three on-line databases [Pubmed, Embase, and Cochrane Library (CENTRAL)] were retrieved from January 2000 to November 2021. Read More

Maturitas 2022 Jun 9;163:62-81. Epub 2022 Jun 9.

Service de gynécologie-obstétrique et médecine de la reproduction, CHU de Poitiers, 2, rue de la Milétrie, 86000 Poitiers, France.

Aim: The aim of these recommendations is to set forth an individualized approach to the management of early postmenopausal women (i.e., within the first 10 years after natural menopause) covering all aspects of lifestyle and therapeutic management, with or without menopause hormone therapy (MHT). Read More

Clin Transl Allergy 2022 Jun 5;12(6):e12150. Epub 2022 Jun 5.

Department of Pediatric Pneumonology and Allergy Medical University of Warsaw Warsaw Poland.

Background: Results of preventative emollient therapy on atopic dermatitis and food allergy trials are inconsistent. In addition to the ingredients considered beneficial, the moisturizers may contain potentially harmful haptens. This study aimed to assess the prevalence of haptens in moisturizers used in studies to prevent atopic dermatitis or food allergy and assess their correlations to the trial results. Read More

J Drugs Dermatol 2022 Jun;21(6):602-612

Background: Acne vulgaris (acne) is a common, complex, multifactorial disorder. Various expressions of acne in childhood can be categorized by age, severity, and pubertal status.

Objective: To improve pediatric acne patients’ outcomes, various expressions of pediatric acne to educate and tailor nonprescription acne treatment and skincare using cleansers and moisturizers were defined and discussed. Read More

J Drugs Dermatol 2022 Jun;21(6):574-580

Background: While rosacea is a common inflammatory condition that affects diverse populations, published data in skin of color (SOC) are limited. This review explored nuances in clinical presentation and treatment considerations in SOC patients with rosacea and the role of cleansers and moisturizers in the management of rosacea in these populations.

Methods: A panel reviewed and discussed aspects of rosacea in SOC and possible implications for treatment and maintenance. Read More

Skin Health Dis 2021 Dec 14;1(4):e65. Epub 2021 Sep 14.

Department of Dermatology Aarhus Universitetshospital Skejby Aarhus Denmark.

Background: Ichthyosis Vulgaris (IV) is a common genetic skin disease, characterized by dry, scaling skin and itch. Urea cream has been a central part of IV treatment for decades, but only few studies have evaluated the effect of urea compared to basic moisturizers.

Objective: To evaluate the treatment effect of 7. Read More

Occup Med (Lond) 2022 May 31. Epub 2022 May 31.

Department of Dermatology, Environmental Medicine and Health Theory, Osnabrück University, Osnabrück, Germany.

Background: Healthcare workers (HCWs) are at high risk of developing hand eczema (HE). This can be exacerbated by hygiene measures related to the coronavirus disease (COVID-19). Using mild skin cleansers and emollients or moisturizers is central in the prevention of HE-especially with increased COVID-19 hygiene regimes. Read More

Asian Pac J Allergy Immunol 2022 May 22. Epub 2022 May 22.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Moisturizers play an important role in restoring the skin barrier. They should be used to treat and prevent eczema, especially in atopic dermatitis (AD).

Objective: To evaluate the factors that influence selection of moisturizers in adult patients with AD and without it. Read More

J Dermatol Sci 2022 Apr 26. Epub 2022 Apr 26.

Department of Dermatology, Kyorin University School of Medicine, Mitaka, Japan.

J Dermatol 2022 May 13. Epub 2022 May 13.

Faculty of Pharmacy, Research Institute for Medicine (iMed.ULisboa), Universidade de Lisboa, Lisbon, Portugal.

The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enforced the use of hand sanitation and of personal protective equipment, such as masks and visors, especially by health-care professionals, but also by the general public. However, frequent hand sanitation and the prolonged and continuous use of personal protective equipment are responsible for constant frictional and pressure forces on skin causing lesions, the most reported being acne, facial itching, dryness, and rash. Thus, it is important to find measures to prevent skin lesions, in order to improve the quality of life of health-care professionals and of the general public. Read More

Burns 2022 Apr 29. Epub 2022 Apr 29.

Burn Center, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium; Department of Plastic Surgery, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium.

Background: The mainstay of non-invasive scar management, consists of pressure therapy with customized pressure garments often combined with inlays, hydration by means of silicones and/or moisturizers as well as UV protection. It is generally accepted that scar dehydration resulting from impaired barrier function of the stratum corneum and expressed by raised trans epidermal water loss (TEWL) values, can lead to increased fibroblast activity and thereby hypertrophic scar formation. However, we have reached no consensus on exactly what optimal scar hydration is nor on barrier function repair: by means of silicone sheets, liquid silicone gels or moisturizers. Read More

J Drugs Dermatol 2022 May;21(5):462-470

Background: Research on the role of race and ethnicity in the pathophysiology of atopic dermatitis (AD) is limited. Variations in the epidemiology, clinical presentation, and disease course in skin of color SOC AD patients have been reported. This manuscript seeks to offer insights into distinct features of AD in populations with (SOC) and provide recommendations on the role of skincare in treating AD amongst diverse populations. Read More

Skinmed 2022 30;20(2):94-96. Epub 2022 Apr 30.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA.

Skincare products containing ingredients derived from , more commonly known as Cica, have become popular as anti-aging remedies, moisturizers, anti-inflammatory drugs, and in treating scars, wounds, and atopic dermatitis, among other skin conditions. Cica has been used in homeopathy for centuries to treat a variety of ailments. Due to the many purported benefits of its skincare formulations, we examined the mechanisms of cica and reviewed the existing literature in order to shed more light on its role in dermatology. Read More

Cureus 2022 Apr 2;14(4):e23750. Epub 2022 Apr 2.

Geriatrics Mental Health, King George's Medical University, Lucknow, IND.

Background: Ventilator-associated pneumonia (VAP) is one of the most common infections in intubated intensive care unit (ICU) patients. Oral care with chlorhexidine is a conventional method for maintaining hygiene. Recently, adjuvant methods have been introduced into routine oral care, including teeth brushing and the application of moisturizing lotion. Read More

Bioresour Technol 2022 Sep 26;359:127235. Epub 2022 Apr 26.

Center of Excellence in Catalysis for Bioenergy and Renewable Chemicals (CBRC), Faculty of Science, Chulalongkorn University, Pathum wan, Bangkok 10330, Thailand; Center of Excellence on Petrochemical and Materials Technology (PETROMAT), Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.

The macroalgal industry is expanding, and the quest for novel ingredients to improve and develop innovative products is crucial. Consumers are increasingly looking for natural-derived ingredients in cosmetic products that have been proven to be effective and safe. Macroalgae-derived compounds have growing popularity in skincare products as they are natural, abundant, biocompatible, and renewable. Read More

J Am Acad Dermatol 2022 Apr 27. Epub 2022 Apr 27.

Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas. Electronic address:

Rev Lat Am Enfermagem 2022 20;30:e3551. Epub 2022 Apr 20.

Universidade Federal do Maranhão, Centro de Ciências Sociais, Saúde e Tecnologia, Imperatriz, MA, Brasil.

Objective: to identify the diverse scientific evidence on the types of skin lesions caused due to the use of Personal Protective Equipment in health professionals during the COVID-19 pandemic and to verify the recommended prevention measures.

Method: this is an integrative review carried out in the MEDLINE, CINAHL, LILACS, SCOPUS, Science Direct, Web of Science and SciELO databases. The search was conducted in a paired manner, constituting a sample of 17 studies categorized according to the types of skin lesions and preventive measures. Read More

Gan To Kagaku Ryoho 2022 Apr;49(4):421-424

Dept. of Nursing, Hyogo College of Medicine.

Preemptive skin treatment led by nurses and pharmacists was started for patients with metastatic colorectal cancer (mCRC)who received anti-EGFR antibody treatment. Incidence of skin-related toxicities, amount of topical moisturizers used, and administered cycles of anti-EGFR antibody were retrospectively compared between a preemptive skin treatment group and a control group. Thirty-four mCRC patients before the introduction of preemptive skin treatment led by nurses and 23 mCRC patients treated with preemptive skin treatment led by nurses were evaluated. Read More

J Cosmet Dermatol 2022 Apr 18. Epub 2022 Apr 18.

Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.

Introduction: Moisturizers play an essential role in maintaining the integrity of the skin barrier by increasing stratum corneum hydration (SCH) and reducing transepidermal water loss (TEWL). According to dermatology and allergy guidelines, moisturizers should be applied on the skin within 3 min after bathing or showering. However, there is very little evidence supporting this recommendation. Read More

Curr Dermatol Rep 2022 7;11(2):41-51. Epub 2022 Apr 7.

Occupational Dermatology Research and Education Centre, Skin Health Institute, Level 1/80 Drummond Street, Carlton, 3053 Australia.

Purpose Of Review: Irritant contact dermatitis is the most common form of contact dermatitis and the most common occupational skin disease. This review provides a comprehensive summary of the endogenous and exogenous factors that play a role in the pathogenesis of irritant contact dermatitis.

Recent Findings: In conjunction with avoidance of irritants, barrier protection, and regular application of moisturizers, management now emphasizes the importance of primary prevention through educational initiatives in high-risk workplaces. Read More

FP Essent 2022 04;515:32-42

Department of Family Medicine - University of California San Diego School of Medicine, 402 Dickinson St, San Diego, CA 92103.

(GSM) is a term that describes the genital, urinary, and sexual changes that occur in women because of a lack of estrogen. This most commonly is because of menopause, but can be because of a hypoestrogenic state caused by hyperprolactinemia, oophorectomy, premature ovarian failure, chemotherapy, or radiation. GSM describes a group of signs and symptoms that affect quality of life and progress over time, including vaginal dryness, dyspareunia, dysuria, urinary urgency, and frequent urinary tract infections. Read More

Pediatr Dermatol 2022 Apr 12. Epub 2022 Apr 12.

Maternal Nursing and Midwifery, Graduate Faculty of Interdisciplinary Research, Graduate School, University of Yamanashi, Chuo, Japan.

Background/objectives: Some full-term newborns present with erythema and irritation of the buttocks and perianal area as early as the first 4 days of their lives. The effect of moisturizers in protecting this vulnerable skin has not been rigorously studied. This study aimed to clarify whether there is a difference in perianal skin barrier function with and without moisturizer application in the first month of life. Read More

Dermatol Ther (Heidelb) 2022 Apr 10;12(4):1041-1054. Epub 2022 Apr 10.

Department of Health Economics and Outcomes Research, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

Introduction: Molecular targeted therapies (MTTs) cause skin disorders in patients with cancer, and moisturizers are useful treatments; however, their actual use and costs are unknown. Our purpose was to examine the use and costs of moisturizers prescribed for xerosis (asteatosis) in patients with cancer treated with MTTs.

Methods: We used data from a Japanese hospital-based claims database. Read More

J Sex Med 2022 05 31;19(5):761-770. Epub 2022 Mar 31.

Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy; Center for Applied Biomedical Research, Department of Surgical and Medical Sciences, S. Orsola-Malpighi University Hospital, Alma Mater Studiorum University of Bologna, Bologna, Italy. Electronic address:

Background: Among treatments for vulvo-vaginal atrophy (VVA), there is a new kind of energy-based device, the non-ablative CO laser.

Aim: This study aimed to assess the efficacy and safety of the non-ablative CO laser in menopausal women with VVA as a monotherapy or in association with vaginal estriol or moisturizer.

Methods: Seventy-five women with VVA received laser treatment (Laser group), laser plus estriol gel (Laser+E) or laser plus moisturizers (Laser+M). Read More

J Cosmet Sci 2021 Mar-Apr;72(2):201-213

Center for Research & Training in Skin Diseases & Leprosy, Tehran University of Medical Sciences, Tehran, 1416613675 Iran.

Although several commercial moisturizers are available in the market, the continued role of pharmaceutical compounding has been still felt in dry skin management. This study aimed to evaluate the effect of a ureabased compounded moisturizer on barrier function, compared with a similar commercial product. Thirty volunteers with a mean age of 36. Read More

World J Clin Oncol 2022 Feb;13(2):71-100

Department of Mother and Child Health and Radiology, Faculty of Medicine, University of Cadiz, Cádiz 11100, Spain.

There is increasing attention about managing the adverse effects of adjuvant therapy (Chemotherapy and anti-estrogen treatment) for breast cancer survivors (BCSs). Vulvovaginal atrophy (VVA), caused by decreased levels of circulating estrogen to urogenital receptors, is commonly experienced by this patients. Women receiving antiestrogen therapy, specifically aromatase inhibitors, often suffer from vaginal dryness, itching, irritation, dyspareunia, and dysuria, collectively known as genitourinary syndrome of menopause (GSM), that it can in turn lead to pain, discomfort, impairment of sexual function and negatively impact on multiple domains of quality of life (QoL). Read More

Clin Drug Investig 2022 Apr 22;42(4):365-374. Epub 2022 Mar 22.

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Tralokinumab (tralokinumab-ldrm) [Adbry (USA); Adtralza (EU)], a human IgG4 monoclonal antibody that binds specifically to interleukin (IL)-13, is an effective and generally well tolerated treatment option for adult patients with moderate to severe atopic dermatitis who are candidates for systemic therapy. In pivotal phase III trials, subcutaneous tralokinumab improved the clinical signs and symptoms of atopic dermatitis as well as quality of life (QOL). In ECZTRA 1 and 2, tralokinumab monotherapy was superior to placebo in the first 16 weeks of treatment, with improvements in pruritus and sleep scores seen as early as week 1. Read More

J Cosmet Dermatol 2022 Mar 17. Epub 2022 Mar 17.

Department of Pigmentation Research and Therapeutics, Osaka City University, Osaka, Japan.

Background: Many patients with atopic dermatitis (AD) have a decreased ability to sweat. Several factors can cause decreased perspiration, such as weak tight junctions of sweat ducts, reduced acetylcholine receptor function, and inhibition of perspiration by histamines. Parakeratosis of AD skin also decreases sweating by occluding sweat pores. Read More