686 results match your criteria Moisturizers


Evaluation of a Comprehensive Skin Toxicity Program for Patients Treated With Epidermal Growth Factor Receptor Inhibitors at a Cancer Treatment Center.

JAMA Dermatol 2020 Jul 1. Epub 2020 Jul 1.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Importance: Up to 90% of patients treated with an epidermal growth factor receptor inhibitor (EGFRi) experience cutaneous toxic effects that are negatively associated with quality of life and lead to treatment interruptions. The Skin Toxicity Evaluation Protocol With Panitumumab trial found reduced incidence of skin toxicity and quality of life impairment with preemptive use of doxycycline hyclate, topical corticosteroids, moisturizers, and sunscreen, demonstrating the benefit of prophylactic treatment for skin toxicity.

Objective: To evaluate the association of a comprehensive skin toxicity program with adherence to prophylaxis guidelines for the prevention of EGFRi-associated cutaneous toxic effects. Read More

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http://dx.doi.org/10.1001/jamadermatol.2020.1795DOI Listing

Treatments for Childhood Atopic Dermatitis: an Update on Emerging Therapies.

Authors:
Chia-Yu Chu

Clin Rev Allergy Immunol 2020 Jun 30. Epub 2020 Jun 30.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7, Chung-Shan South Road, Taipei, 10002, Taiwan.

Atopic dermatitis (AD) is generally considered a T helper type 2-dominated disease. Pediatric AD is usually less severe than adult AD, but it may present as moderate to severe lesions that are inadequately managed by current modalities including emollients/moisturizers, topical corticosteroids (TCSs), topical calcineurin inhibitors (TCIs), and even systemic immunosuppressants (such as cyclosporine, azathioprine, methotrexate, and mycophenolate mofetil). In addition, systemic immunosuppressants are often not recommended for childhood AD by the current guidelines due to their toxicities. Read More

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http://dx.doi.org/10.1007/s12016-020-08799-1DOI Listing

Cosmeceutical awareness among community pharmacists in Jeddah, Saudi Arabia: The case of sunscreens and moisturizers.

J Cosmet Dermatol 2020 Jun 23. Epub 2020 Jun 23.

Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.

Background: Although cosmetic products such as sunscreens and moisturizers are generally considered safe, they can be less effective or harmful if used improperly. Thus, pharmacist's awareness about cosmeceuticals is pivotal in counseling about the ingredients and the proper use of such products.

Objective: To evaluate the awareness level of community pharmacists regarding cosmetic products particularly sunscreens and moisturizers in Jeddah, Saudi Arabia. Read More

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http://dx.doi.org/10.1111/jocd.13536DOI Listing

Nivolumab-induced contact dermatitis in a patient with advanced lung cancer.

Respir Med Case Rep 2020 15;30:101134. Epub 2020 Jun 15.

Department of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, Japan.

An 85-year-old man was being treated for advanced squamous cell lung carcinoma with nivolumab as a second-line treatment. From the beginning of the third course, erythema appeared on his trunk and gradually progressed. Around the start of the fifth course, erythema spread to the proximal part of all limbs in addition to the trunk and was accompanied by a strong itching sensation. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303977PMC

Efficacy of Nonprescription Moisturizers for Atopic Dermatitis: An Updated Review of Clinical Evidence.

Am J Clin Dermatol 2020 Jun 10. Epub 2020 Jun 10.

College of Nursing, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.

Twice-daily moisturization is recommended by international guidelines as the bedrock of the management of atopic dermatitis (AD). Moisturizers should be selected based on proven clinical effectiveness in improving the skin barrier and improving the symptoms of AD. We searched the PubMed database for clinical trials assessing daily moisturization for the treatment of AD published between 2006 and 2019. Read More

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http://dx.doi.org/10.1007/s40257-020-00529-9DOI Listing

Parental knowledge of moisturizers and their application to infants with eczema in Hangzhou, China.

Medicine (Baltimore) 2020 May;99(22):e20329

The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Parental knowledge regarding the role of moisturizers in restoring the skin barrier, as well as regular and long-term use of moisturizers, is critical in the treatment of infantile eczema and the prevention of relapse.The parents of children with eczema were enrolled in this study. Their knowledge of the role, use, and effect of moisturizers on their children, as well as their concerns regarding moisturizers were surveyed. Read More

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http://dx.doi.org/10.1097/MD.0000000000020329DOI Listing
May 2020
5.723 Impact Factor

Contact haptens in emollients marketed in two European countries (Poland and Spain).

Allergol Immunopathol (Madr) 2020 May 24. Epub 2020 May 24.

Department of Pediatric Respiratory Diseases and Allergy, The Medical University of Warsaw, Żwirki i Wigury 63A, PL-02-091 Warsaw, Poland. Electronic address:

Introduction And Objectives: Atopic dermatitis (AD) is the most common skin disease among pediatric patients, which affects up to 20% of children worldwide. Characterized by pruritus and eczema, it is also associated with improper skin barrier function and allergen sensitization. Here, we aimed to assess the presence of haptens in emollients marketed in two European countries: in Poland and Spain, as, firstly, these products are considered to be AD's basic therapy, and, secondly, frequent application of potent sensitizers on atopic skin may result in contact dermatitis. Read More

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http://dx.doi.org/10.1016/j.aller.2020.04.002DOI Listing

Effects of processing conditions and glycerol concentration on rheological and texture properties of starch-based hydrogels produced by high pressure processing (HPP).

Int J Biol Macromol 2020 May 16;159:590-597. Epub 2020 May 16.

Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy; ProdAl Scarl c/o University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy. Electronic address:

Starch-based hydrogels are natural polymeric structures which could be potentially utilized in food, pharma and cosmetic sectors to produce creams, gels and ointments, as well as functional foods and products for personalized nutrition. In this paper, the effects of processing conditions (pressure levels and holding time) on gelation of corn and rice starch solutions were evaluated also in presence of glycerol. Considering the utmost importance of humectants as active moisturizers in gels, their addition in starch solutions has been investigated in view of the industrial exploitation of HPP starch-based hydrogels. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.05.120DOI Listing

The Genitourinary Syndrome of Menopause: An Overview of the Recent Data.

Cureus 2020 Apr 8;12(4):e7586. Epub 2020 Apr 8.

Urogynecology Unit, Alexandra Hospital-National and Kapodistrian University of Athens, Athens, GRC.

The genitourinary syndrome of menopause (GSM) is a relatively new term for the condition previously known as vulvovaginal atrophy, atrophic vaginitis, or urogenital atrophy. The term was first introduced in 2014. GSM is a chronic, progressive, vulvovaginal, sexual, and lower urinary tract condition characterized by a broad spectrum of signs and symptoms. Read More

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http://dx.doi.org/10.7759/cureus.7586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212735PMC

Comparing the Potential for Irritation of a Ceramide-Based Moisturizer with a Urea-Based Moisturizer for Pediatric Atopic Dermatitis.

Dermatol Ther (Heidelb) 2020 May 6. Epub 2020 May 6.

Dermatology Service, KK Women's and Children's Hospital, Singapore, Singapore.

Introduction: Moisturizers are one of the mainstays of the topical treatment of atopic dermatitis (AD). One of the adverse effects of moisturizers is skin irritation, especially on excoriated AD skin. We compared the potential for irritation of two commercially available moisturizer products for the treatment of AD: a ceramide-based moisturizer (Ceradan Cream; Hyphens Pharma Pte Ltd, Singapore) and a urea 5% moisturizer (Aqurea Lite Cream; ICA Pharma Pte Ltd, Singapore). Read More

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http://dx.doi.org/10.1007/s13555-020-00388-6DOI Listing

Allergic Contact Dermatitis Secondary to Moisturizers.

J Cutan Med Surg 2020 Apr 15:1203475420919396. Epub 2020 Apr 15.

12280 Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

: Moisturizers are cosmetic products used routinely to manage various skin conditions. Even though moisturizers are often thought to have minimal or no adverse reactions, allergic contact dermatitis (ACD) to these products can develop in some cases. : We studied ingredients included in 3 of the most commonly used moisturizer brands, identified their presence in standard patch testing series, and evaluated their allergenic potential, categorizing the allergens as frequent or infrequent. Read More

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http://dx.doi.org/10.1177/1203475420919396DOI Listing

A randomized half-body, double blind, controlled trial on the effects of a pH-modified moisturizer vs. standard moisturizer in mild to moderate atopic dermatitis.

An Bras Dermatol 2020 May - Jun;95(3):320-325. Epub 2020 Mar 21.

Department of Pharmacy, University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Background: Higher skin pH in atopic dermatitis contributes to impaired epidermal barrier. A moisturizer compatible with physiological pH could improve atopic dermatitis.

Objective: To determine the effect of a physiologically compatible pH moisturizer in atopic dermatitis. Read More

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http://dx.doi.org/10.1016/j.abd.2019.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253898PMC

Local treatment with a polycarbophil-based cream in postmenopausal women with genitourinary syndrome of menopause.

Int Urogynecol J 2020 Mar 23. Epub 2020 Mar 23.

Division of Urology, Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Introduction And Hypothesis: Genitourinary syndrome of menopause (GSM) is a common problem associated with lower urinary tract and gynecological symptoms due to the decrease in estrogen production in postmenopausal women. Topical estrogen therapy is shown to improve these symptoms; nonetheless, there are limited data on the efficacy of nonhormonal moisturizers in these patients.

Methods: A prospective cohort study was conducted to compare the symptoms of GSM before and after treatment with a polycarbophil-based cream in 42 women. Read More

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http://dx.doi.org/10.1007/s00192-020-04282-9DOI Listing

Single application of lamellar moisturizers provides significantly increased hydration of the stratum corneum for up to 24 hours in a randomized trial.

J Cosmet Dermatol 2020 Mar 13. Epub 2020 Mar 13.

Skin Health Medical Affairs, GSK Consumer Healthcare, Weybridge, UK.

Background: Some moisturizing formulations can help restore and maintain the barrier function of the skin.

Objectives: This study was designed to assess the hydration potential of three lamellar moisturizers relative to a control (nonlamellar) moisturizer.

Methods: Healthy adults aged 18 to 65 years with self-reported sensitive skin, dry or very dry skin and Corneometry values of ≤40 a. Read More

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http://dx.doi.org/10.1111/jocd.13361DOI Listing

Effects of denture adhesives and mouth moisturizers to human oral fibroblast and human keratinocyte cells using direct and indirect cell culture systems.

Dent Mater J 2020 Feb 29. Epub 2020 Feb 29.

Department of Prosthetic Dentistry, Graduate School of Biomedical Sciences, Nagasaki University.

The purpose of this study was to evaluate the effects of commercialized denture adhesives and mouth moisturizers using direct and indirect cell cultures for in vitro examinations with human fibroblast and epithelial cells. Denture adhesives (Faston, Poligrip Powder, New Poligrip Free, Tafugurippu Kurimu, Polident Adhesive, Tafugurippu Tomei) and mouth moisturizers (Concool Mouth Gel, Biotene Oral Balance Gel) were subjected to live and dead detection and pH level determination. The mouth moisturizers showed higher cytotoxicity effects comparing with control on every cell cultures and cells, and pH level did not show any significant differences. Read More

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http://dx.doi.org/10.4012/dmj.2017-332DOI Listing
February 2020

Men's Facial Moisturizers in the Metrosexual Era: Characteristics, Allergens, and Relevance of Men's Products in Modern Dermatology.

Dermatitis 2020 Feb 21. Epub 2020 Feb 21.

From the Department of Dermatology, Minneapolis Veterans Affairs Medical Center.

Background: Manufacturers are increasingly branding personal care products (PCPs) specifically for men.

Objective: The aim of the study was to characterize ingredients and claims of facial moisturizers marketed to men.

Methods: Men's facial moisturizers from 7 different online retailers were identified in June-September 2018. Read More

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http://dx.doi.org/10.1097/DER.0000000000000561DOI Listing
February 2020

Atopic Dermatitis in Older Adults: A Review of Treatment Options.

Authors:
Ryoji Tanei

Drugs Aging 2020 03;37(3):149-160

Department of Dermatology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 35-2 Sakaecho, Itabashi, Tokyo, 173-0015, Japan.

Atopic dermatitis (AD) in older adults (elderly AD) has recently emerged as a newly defined subgroup of AD. When selecting treatment options, clinical characteristics of elderly AD and age-specific factors of older patients must be considered. As in other age groups, regular application of moisturizers in combination with topical corticosteroids and calcineurin inhibitors, adjunctive administration of oral antihistamines/anti-allergic drugs, and avoidance of exacerbating factors comprise basic treatments for elderly AD. Read More

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http://dx.doi.org/10.1007/s40266-020-00750-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044141PMC

Evaluation of factors that may affect disease development and severity in childhood atopic dermatitis.

G Ital Dermatol Venereol 2020 Feb 13. Epub 2020 Feb 13.

Department of Dermatology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.

Background: Atopic dermatitis is a chronic, relapsing, inflammatory disease. Data concerning the role of perinatal conditions in the development of the disease are few and inconsistent. The purpose of this study was to investigate the effects of skin care on the severity of the disease, also to evaluate the relations of perinatal conditions with disease development and severity. Read More

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http://dx.doi.org/10.23736/S0392-0488.20.06469-XDOI Listing
February 2020

Changes in skin barrier function following single and repeated applications of 4 types of moisturizers: a randomized controlled trial.

J Eur Acad Dermatol Venereol 2020 Jun 4;34(6):e288-e290. Epub 2020 Mar 4.

Center for Research & Training in Skin Diseases & Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1111/jdv.16288DOI Listing

Ospemifene in the Management of Vulvar and Vaginal Atrophy: Focus on the Assessment of Patient Acceptability and Ease of Use.

Patient Prefer Adherence 2020 10;14:55-62. Epub 2020 Jan 10.

Obstetrics and Gynaecology Unit, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy.

Endocrinological changes that occur with menopause lead to a chronic and progressive condition named vulvar and vaginal atrophy (VVA). This disease is characterized by symptoms such as dryness, dyspareunia, itching, burning, and dysuria. According to recent epidemiological studies, VVA has a high prevalence and can also occur in younger women prior to the menopause, negatively affecting quality of life, sexual function, intimacy and relationship with the partner. Read More

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http://dx.doi.org/10.2147/PPA.S203614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959488PMC
January 2020

Vaginal Dilators: Issues and Answers.

Sex Med Rev 2020 Jan 31. Epub 2020 Jan 31.

University of California Irvine, Department of OBGYN, Irvine, CA, USA; Southern California Center for Sexual Health and Survivorship Medicine Inc, Newport Beach, CA, USA. Electronic address:

Introduction: Vaginal dilators are often prescribed to facilitate an adaptive brain-body connection to decrease anxiety and pain that can be experienced in anticipation of sexual intercourse among populations of women with sexual pain syndromes. Postmenopausal women, cancer survivors, and women with a wide variety of pelvic floor disorders who experience genito-pelvic pain/penetration disorder (GPPPD) are often advised to incorporate vaginal dilators into their pelvic floor rehabilitation program and treatment regimens to enable penetrative intercourse with less pain. However, little is known about the behaviors of dilator users, what treatment protocols are most effective, how patients are currently using their dilators, and how effective are clinicians in helping their patients achieve success with their dilation therapy. Read More

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http://dx.doi.org/10.1016/j.sxmr.2019.11.005DOI Listing
January 2020

A behaviour change package to prevent hand dermatitis in nurses working in the National Health Service: results of a cluster randomized controlled trial.

Br J Dermatol 2020 Jan 27. Epub 2020 Jan 27.

Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK.

Background: Occupational hand dermatitis poses a serious risk for nurses.

Objectives: To evaluate the clinical and cost-effectiveness of a complex intervention in reducing the prevalence of hand dermatitis in nurses METHODS: This was a cluster randomized controlled trial conducted at 35 hospital trusts, health boards or universities in the UK. Participants were (i) first-year student nurses with a history of atopic conditions or (ii) intensive care unit (ICU) nurses. Read More

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http://dx.doi.org/10.1111/bjd.18862DOI Listing
January 2020

Novel functions for 2-phenylbenzimidazole-5-sulphonic acid: Inhibition of ovarian cancer cell responses and tumour angiogenesis.

J Cell Mol Med 2020 Feb 20;24(4):2688-2700. Epub 2020 Jan 20.

Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, Korea.

In this study, we investigated the effects and molecular mechanisms of 2-phenylbenzimidazole-5-sulphonic acid (PBSA), an ultraviolet B protecting agent used in sunscreen lotions and moisturizers, on ovarian cancer cell responses and tumour angiogenesis. PBSA treatment markedly blocked mitogen-induced invasion through down-regulation of matrix metalloproteinase (MMP) expression and activity in ovarian cancer SKOV-3 cells. In addition, PBSA inhibited mitogen-induced cell proliferation by suppression of cyclin-dependent kinases (Cdks), but not cyclins, leading to pRb hypophosphorylation and G phase cell cycle arrest. Read More

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http://dx.doi.org/10.1111/jcmm.14989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028853PMC
February 2020

Ospemifene: A Novel Oral Therapy for Vulvovaginal Atrophy of Menopause.

J Obstet Gynaecol Can 2020 Mar 10;42(3):301-303. Epub 2020 Jan 10.

Department of Obstetrics and Gynecology, Ohio State University College of Medicine, Columbus, OH.

Vulvovaginal atrophy (VVA) resulting from estrogen deprivation at menopause often results in distressing vaginal dryness and dyspareunia. Fewer than 25% of affected women seek help for this condition citing embarrassment, cultural values, an aging or unavailable partner and concerns about use of estrogens following the Women's Health Initiative. Available non-hormonal treatments, such as moisturizers, while affording some relief can be messy to apply and do not prevent disease progression. Read More

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http://dx.doi.org/10.1016/j.jogc.2019.10.039DOI Listing

Management of aging skin: A questionnaire-based study among Indian dermatologists.

J Cosmet Dermatol 2019 Dec 30. Epub 2019 Dec 30.

Cipla Ltd., Mumbai, India.

Introduction: With increased life expectancy, the desire to look younger has increased. Hence, many patients approach dermatologists for antiaging treatment. However, data regarding management of skin aging in India are scarce. Read More

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http://dx.doi.org/10.1111/jocd.13279DOI Listing
December 2019

Diabetic Skin Changes Can Benefit from Moisturizer and Cleanser Use: A Review

J Drugs Dermatol 2019 Dec;18(12):1211-1217

INTRODUCTION: Diabetes mellitus (DM) associated skin changes, which may be the first sign of DM in undiagnosed patients. Frequently these patients present with dry skin, which may benefit from the use of gentle cleansers and moisturizers. A review paper was developed to explore DM-associated skin changes and possible benefits of cleanser and moisturizer use. Read More

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December 2019

[Current aspects of the treatment of urogenital atrophy (based on the consensus of britain society of menopause)].

Urologiia 2019 Dec(5):150-154

GBUZ MO Moscow Regional Scientific and Research Institute of Obstetrics and Gynecology, Moscow, Russia.

The symptoms of genitourinary syndrome of menopause are considered as typical for late menopausal period. However, these symptoms are increasingly diagnosed in perimenopausal and early menopausal period. Women seldom seek medical care, since autonomic menopausal symptoms are usually more bothersome. Read More

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December 2019

Pathogenesis, Clinical Signs and Treatment Recommendations in Brittle Nails: A Review.

Dermatol Ther (Heidelb) 2020 Feb 20;10(1):15-27. Epub 2019 Nov 20.

Dermatology Unit, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Nail plate brittleness (or fragility) is a common complaint affecting up to 20% of the population, especially women over 50 years of age, with fingernail fragility being more prevalent than toenail fragility. Nail brittleness is characterized by nails that split, flake and crumble, become soft and lose elasticity. The main clinical presentations are: onychoschizia, onychorrhexis, superficial granulation of keratin and worn-down nails. Read More

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http://dx.doi.org/10.1007/s13555-019-00338-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994568PMC
February 2020

Could squalene be an added value to use olive by-products?

J Sci Food Agric 2020 Feb 27;100(3):915-925. Epub 2019 Nov 27.

Instituto Agroalimentario de Aragón, CITA-Universidad de Zaragoza, Spain.

Squalene (SQ) is an intermediate hydrocarbon in the biosynthesis of phytosterols and terpenes in plants. It is widely used for applications such as skin moisturizers, vaccines, or in carriers for active lipophilic molecules. It has commonly been obtained from sharks, but restrictions on their use have created a need to find alternative sources. Read More

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http://dx.doi.org/10.1002/jsfa.10116DOI Listing
February 2020

Chemical/straightening and other hair product usage during childhood, adolescence, and adulthood among African-American women: potential implications for health.

J Expo Sci Environ Epidemiol 2020 Jan 22;30(1):86-96. Epub 2019 Oct 22.

Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.

Few studies have characterized life course hair product usage beyond ever/never. We investigated hair product use from childhood to adulthood, usage patterns in adulthood, and socioeconomic status (SES) correlates among African-American (AA) women. Using self-reported data from 1555 AA women enrolled in the Study of Environment, Lifestyle, and Fibroids (2010-2018), we estimated the usage frequency of chemical relaxer/straightener (≥twice/year, once/year, and rarely/never) and leave-in/leave-on conditioner (≥once/week, 1-3 times/month, and rarely/never) during childhood, adolescence, and adulthood. Read More

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http://dx.doi.org/10.1038/s41370-019-0186-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917990PMC
January 2020

Qualification of a non-animal vaginal irritation method admitted as nonclinical assessment model (NAM) in the Incubator Phase of the United States Food and Drug Administration (US FDA) Medical Devices Development Tool (MDDT).

Toxicol In Vitro 2020 Feb 15;62:104680. Epub 2019 Oct 15.

PETA International Science Consortium Ltd, London, United Kingdom. Electronic address:

The U.S. Food and Drug Administration (FDA) Center for Devices and Radiological Health (CDRH) classifies personal lubricants as Class II medical devices. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.104680DOI Listing
February 2020
2 Reads

Pharmacological treatments for cutaneous manifestations of inherited ichthyoses.

Arch Dermatol Res 2020 May 17;312(4):237-248. Epub 2019 Oct 17.

Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Coyoacán, 04510, Mexico City, Mexico.

Inherited ichthyoses are a group of etiologically heterogeneous diseases that affect the function of the skin and that are classified as syndromic and non-syndromic entities. Irrespective of the type, all these disorders are generally produced by mutations in genes involved in a variety of cellular functions in the skin. These mutations lead to disruption of the stratum corneum and impairment of the skin barrier, producing clinical features such as hyperkeratosis, skin scaling, erythema, fissures, pruritus, inflammation, and skin pain. Read More

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http://dx.doi.org/10.1007/s00403-019-01994-xDOI Listing
May 2020
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Efficacy of anti-inflammatory moisturizer vs hydrophilic cream in elderly patients with moderate to severe xerosis: A split site, triple-blinded, randomized, controlled trial.

J Cosmet Dermatol 2020 Jun 14;19(6):1432-1438. Epub 2019 Oct 14.

Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.

Background: Xerosis is a common problem among the elderly, characterized by dry-scaling erythema, fissuring, or pruritus, which could be treated by anti-inflammatory moisturizers without side effects of steroids.

Aims: We aimed to investigate the efficacy of anti-inflammatory moisturizer (MAS062D lotion) vs hydrophilic cream for the improvement of dry and barrier function skin in xerosis patients.

Methods: A split site, triple-blinded, randomized, controlled trial was conducted in the elderly with moderate to severe xerosis, who received the 28-day twice daily application of MAS062D lotion and hydrophilic cream on the assigned shins. Read More

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http://dx.doi.org/10.1111/jocd.13183DOI Listing

Imiquimod to prevent keloid recurrence postexcision: A systematic review and meta-analysis.

Wound Repair Regen 2020 Jan 21;28(1):145-156. Epub 2019 Oct 21.

Royal Adelaide Hospital, Adelaide, 5000, South Australia, Australia.

Imiquimod 5% cream, an immune response modifier capable of inducing IFN-α, TNF-α, and interleukins 1, 6, and 8. It was approved for use in the management of genital and perianal warts and soon embraced as a method to diminish the recurrence of keloids postexcision. A previous meta-analysis included four studies. Read More

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http://dx.doi.org/10.1111/wrr.12766DOI Listing
January 2020
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A Global Review on the Risk Factors and Management of Early Atopic Dermatitis in Children Ages 0 to 2 Years Old

Authors:

J Drugs Dermatol 2019 Oct;18(10):1020-1027

Introduction: Atopic dermatitis (AD) is a chronic, relapsing skin disease starting typically in atopic-prone children between 3–6 months of age, with most children having developed AD by the age of 5 years. Intense itching leads to sleep disturbance, especially in younger children and toddlers. This review explores early intervention in infants and young children with AD by controlling skin barrier function and inflammation at the earliest time point using a moisturizer and a proactive treatment. Read More

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October 2019
2 Reads

Tips and Tricks for Controlling Eczema.

Authors:
Rekha Raveendran

Immunol Allergy Clin North Am 2019 11 31;39(4):521-533. Epub 2019 Aug 31.

Division of Allergy/Immunology, Department of Otolaryngology, The Ohio State University Wexner Medical Center, OSU Eye and Ear Institute, 915 Olentangy River Road, Suite 4000, Columbus, OH 43212, USA. Electronic address:

Eczema is a chronic, relapsing, and remitting disease that can affect patients from infancy through adulthood. Severity of eczema ranges from mild to severe and can be plagued with recurrent flares. These flares can be difficult to treat and may require use of different strategies to address the issue. Read More

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http://dx.doi.org/10.1016/j.iac.2019.07.006DOI Listing
November 2019
2 Reads

Comparison of Irritancy Potential of Sodium Lauryl Sulfate-free Aqueous Cream to Other Moisturizers: An Intraindividual Skin Occlusive Study.

J Clin Aesthet Dermatol 2019 Jul 1;12(7):52-58. Epub 2019 Jul 1.

Dr. Chan is with the Duke-NUS Medical School in Singapore.

We compared the irritancy potential of sodium lauryl sulfate (SLS)-free aqueous cream to SLS-containing aqueous cream and other moisturizers. This was a double-blind, intraindividual occlusive study. SLS-containing aqueous cream; SLS-free aqueous cream; white soft paraffin; urea cream; Physiogel® (Stiefel Laboratories, Brentford, United Kingdom); QV cream (Ego Pharmaceuticals Pty. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715333PMC
July 2019
1 Read

Factors Influencing Atopic Dermatitis Incidence in Offspring.

Iran J Allergy Asthma Immunol 2019 Aug 17;18(4):347-357. Epub 2019 Aug 17.

Department of Dermatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Atopic dermatitis (AD) is a chronic, recurrent skin condition resulting from both genetic and environmental factors. In recent decades, the prevalence of AD has increased considerably in some countries. However, given that the role of genetics is unlikely to have changed over this short period, the increased prevalence is more likely to be explained by changes in environmental and maternal factors. Read More

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http://dx.doi.org/10.18502/ijaai.v18i4.1413DOI Listing
August 2019
2 Reads

Visualization of moisturizer effects in stratum corneum in vitro using THz spectroscopic imaging.

Appl Opt 2019 Aug;58(24):6581-6585

We use terahertz time-domain spectroscopic (THz-TDS) imaging for the evaluation of moisturizing-substances effects over stratum corneum (SC) samples. Excised SC of porcine skin is used as an in vitro skin model. We evaluate the interaction of SC samples with glycerine and lanolin, two substances commonly used in moisturizers. Read More

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http://dx.doi.org/10.1364/AO.58.006581DOI Listing

Management of genitourinary syndrome of menopause in female cancer patients: a focus on vaginal hormonal therapy.

Am J Obstet Gynecol 2020 02 29;222(2):103-113. Epub 2019 Aug 29.

Obstetrics/Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, OH.

Genitourinary syndrome of menopause is a condition describing the hypoestrogenic effects on the female genitals and lower urinary tract leading to symptoms such as vaginal dryness, vulvar and vaginal burning, dyspareunia and dysuria. Genitourinary syndrome of menopause is experienced by over half of postmenopausal women, and is even more pervasive in women with cancer. Due to treatments such as surgery, chemotherapy, radiation, and hormonal therapy, women may experience early menopause resulting in earlier and more severe symptoms. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.08.043DOI Listing
February 2020
2 Reads

Practical Treatment Considerations in the Management of Genitourinary Syndrome of Menopause.

Drugs Aging 2019 10;36(10):897-908

Weill Cornell Medical College, New York, NY, USA.

Genitourinary syndrome of menopause is a condition comprising the atrophic symptoms and signs women may experience in the vulvovaginal and bladder-urethral areas as a result of the loss of sex steroids that occurs with menopause. It is a progressive condition that does not resolve without treatment and can adversely affect a woman's quality of life. For a variety of reasons, many symptomatic women do not seek treatment and, of those who do, many are unhappy with their options. Read More

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http://dx.doi.org/10.1007/s40266-019-00700-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764929PMC
October 2019
7 Reads
2.838 Impact Factor

[Modern concept of pruritus diagnosis and therapy].

Authors:
Markus Streit

Ther Umsch 2019 Aug;76(2):92-97

1Dermatologie und Allergologie, Kantonsspital Aarau.

Modern concept of pruritus diagnosis and therapy Pruritus can be best treated when the cause of itching is known, allowing a targeted treatment. To find the cause of itching it is recommended to consult the itch classification system of the «International Forum for the Study of Itch» (IFSI). In here three groups of conditions are distinguished: Pruritus on diseased (inflamed) skin (group I) is caused by a pruritic skin disorder that has to be diagnosed properly; correct treatment of the skin disorder will be the treatment of pruritus. Read More

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http://dx.doi.org/10.1024/0040-5930/a001068DOI Listing
August 2019
3 Reads

Topical Non-Pharmacological Treatment for Facial Seborrheic Dermatitis.

Dermatol Ther (Heidelb) 2019 Sep 8;9(3):469-477. Epub 2019 Aug 8.

Department of Dermatology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain.

Facial seborrheic dermatitis (FSD) is a chronic and relapsing inflammatory skin disorder occurring in areas of the face rich in sebaceous glands. It clinically manifests as erythematous scaly macules or plaques, often associated with pruritus. Although the pathogenesis of seborrheic dermatitis is not yet fully understood, Malassezia yeast, hormones, sebum levels, and immune response are known to play important roles. Read More

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http://dx.doi.org/10.1007/s13555-019-00319-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704200PMC
September 2019
7 Reads

Therapies for the management of genitourinary syndrome of menopause.

Post Reprod Health 2020 Mar 6;26(1):32-42. Epub 2019 Aug 6.

Procare Health Iberia, Barcelona, Spain.

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http://dx.doi.org/10.1177/2053369119866341DOI Listing
March 2020
2 Reads

Cosmetics and Cancer: Adverse Event Reports Submitted to the Food and Drug Administration.

JNCI Cancer Spectr 2018 Apr 20;2(2):pky012. Epub 2018 Jun 20.

Department of Dermatology.

There have been numerous controversies surrounding cosmetic products and increased cancer risk. Such controversies include associations between parabens and breast cancer, hair dyes and hematologic malignancies, and talc powders and ovarian cancer. Despite the prominent media coverage and numerous scientific investigations, the majority of these associations currently lack conclusive evidence. Read More

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http://dx.doi.org/10.1093/jncics/pky012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649728PMC
April 2018
6 Reads

Randomized controlled trial of the effectiveness of three different oral moisturizers in palliative care patients.

Eur J Oral Sci 2019 12 20;127(6):523-530. Epub 2019 Jul 20.

Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, Bergen, Norway.

Most patients in palliative care have problems with dry mouth caused by medication or as a direct result of their condition. Dry mouth may cause problems that affect the primary disease negatively and contribute to poorer quality of life in palliative patients. This randomized controlled trial compared the efficacy of three different oral moisturizers: 17% watery solution of glycerol; oxygenated glycerol triester (marketed as Aequasyal in Europe and as Aquoral in the USA); and a newly developed product, Salient. Read More

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http://dx.doi.org/10.1111/eos.12655DOI Listing
December 2019