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    1 OF 11

    An epidemic of allergic contact dermatitis caused by a new allergen, caprylhydroxamic acid, in moisturizers.
    Contact Dermatitis 2017 Apr 19. Epub 2017 Apr 19.
    Department of Dermatology and Allergy Centre, Tampere University Hospital, 33520, Tampere, Finland.
    Background: In 2016, dermatologists in Finland suspected contact allergy in several patients using moisturizers under the trade name Apobase®. Following a formulation change, Phenostat™, which is a mixture of phenoxyethanol, caprylhydroxamic acid, and methylpropanediol, was used as a preservative in Apobase® moisturizers in Finland.

    Objectives: To confirm the suspected contact allergy to Apobase® cream, oily cream, and/or lotion, and to identify the specific contact allergen and define its optimal patch test concentration. Read More

    Use of vegetable oils in dermatology: an overview.
    Int J Dermatol 2017 Apr 19. Epub 2017 Apr 19.
    Department of Dermatology, MAMC and associated LNJP Hospital, New Delhi, India.
    Vegetable oils have been used for a wide variety of purposes since time immemorial; however, their principle use remains as skin moisturizers, especially in neonates and children. Because of their considerable efficacy and a low side effect profile and bearable cost, these oils are hugely popular as moisturizers among the common people in countries such as India. A wide variety of oils have been used, and newer ones are coming up with each passing day. Read More

    [Confluent and reticulated papillomatosis subsiding spontaneously after delivery: Report of one case].
    Rev Med Chil 2016 Nov;144(11):1494-1496
    Family Medicine Department, American University of Beirut Medical Center, Beirut, Lebanon.
    Gougerot and Carteaud confluent and reticulated papillomatosis (CARP) is an uncommon dermatosis characterized by hyperpigmented scaly macules or papillomatous papules coalescing into confluent patches or plaques centrally with a reticular pattern peripherally. We report a 28-year-old woman presenting at 16 weeks of gestation with an itchy rash that was biopsied and turned out to be consistent with CARP. Options for treatment were discussed but the woman refused to take any systemic therapy and used only moisturizers throughout her pregnancy. Read More

    Management of Atopic Dermatitis in Japan.
    J Nippon Med Sch 2017 ;84(1):2-11
    Department of Dermatology, Nippon Medical School.
    The guidelines for the treatment of atopic dermatitis (AD) issued by the Japanese Dermatological Association (JDA), which are basically designed for dermatologists, were first prepared in 2000 and revised in 2016. The guidelines for AD of the Japanese Society of Allergology (JSA), which are basically designed for allergologists, including internists, otorhinolaryngologists, ophthalmologists, and dermatologists, were first prepared in 2009 and revised in 2014. In this article, I review the definition, pathophysiology, etiology, epidemiology, diagnosis, severity classification, examination for diagnosis and severity assessment, and treatments for AD in Japan according to these two guidelines for AD (JDA and JSA). Read More

    Seeking better topical delivery technologies of moisturizing agents for enhanced skin moisturization.
    Expert Opin Drug Deliv 2017 Mar 20:1-15. Epub 2017 Mar 20.
    a College of Pharmacy , Chung-Ang University , Seoul , Republic of Korea.
    Introduction: An adequate hydration level is essential to maintain epidermal barrier functions and normal physiological activities of skin tissues. Diverse moisturizing agents and pharmaceutical formulations for dermal deliveries have thus extensively been investigated. This review comprehensively discusses scientific outcomes of moisturizing agents and pharmaceutical vehicles for skin moisturization, thereby providing insight into designing innovative pharmaceutical formulations for effective skin moisturization. Read More

    Cosmeceuticals for rosacea.
    Clin Dermatol 2017 Mar - Apr;35(2):213-217. Epub 2016 Oct 27.
    Consulting Professor, Department of Dermatology, Duke University School of Medicine, Durham, North Carolina. Electronic address:
    Patients with rosacea present a challenge to the dermatologist, as they typically possess sensitive skin, need facial Demodex and bacterial colonization control, exhibit vasomotor instability, require camouflaging of telangiectatic mats, and desire prescription treatment. Currently available pharmaceuticals are aimed at inflammation reduction, primarily with the use of topical and oral antibiotics. Recently, vasoconstrictor formulations have emerged, but these drugs have only a temporary effect and improve appearance without addressing the underlying cause, which remains largely unknown. Read More

    A pilot randomized trial to prevent sexual dysfunction in postmenopausal breast cancer survivors starting adjuvant aromatase inhibitor therapy.
    J Cancer Surviv 2017 Feb 22. Epub 2017 Feb 22.
    Department of Behavioral Science, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Purpose: A randomized pilot trial evaluated the hypothesis that early intervention lessens sexual dysfunction in the first year on aromatase inhibitors. A secondary aim was comparing the efficacy of two vaginal moisturizers.

    Methods: Fifty-seven postmenopausal women with early stage breast cancer starting aromatase inhibitors were randomized to three treatment groups. Read More

    Diagnosis and Management of Chronic Pruritus: An Expert Consensus Review.
    Indian J Dermatol 2017 Jan-Feb;62(1):7-17
    Skin Diseases Center, Nashik, Maharashtra, India.
    The aim of this study is to formulate the best clinical practice in the diagnosis and management of chronic pruritus (CP). We searched PubMed, EMBASE, Scopus, Web of Science, and the WHO's regional databases, for studies on "Diagnosis and management of chronic pruritus" from January 1, 2014, to July 31, 2015. We included programmatic reports and hand-searched references of published reviews and articles. Read More

    Multivesicular Emulsion Ceramide-containing Moisturizers: An Evaluation of Their Role in the Management of Common Skin Disorders.
    J Clin Aesthet Dermatol 2016 Dec 1;9(12):26-32. Epub 2016 Dec 1.
    Department of Dermatology, Mount Sinai Hospital, New York, New York.
    Proper stratum corneum function plays a pivotal role in maintenance of skin health, and improper function leads to skin disease. The stratum corneum is comprised of corneocytes surrounded by intercelluar lipids including ceramides, free fatty acids, and cholesterol. Ceramide predominant moisturizers have become a mainstay of treatment of skin disease. Read More

    Characterization and biocompatibility evaluation of cutaneous formulations containing lipid nanoparticles.
    Int J Pharm 2017 Mar 25;519(1-2):373-380. Epub 2017 Jan 25.
    UCIBIO, ReQuimTe, Laboratory of Pharmaceutical Technology/Centre of Research in Pharmaceutical Sciences, Faculty of Pharmacy, Porto University, Porto, Portugal; FP-ENAS (UFP Energy, Environment and Health Research Unit), CEBIMED (Biomedical Research Centre), Faculty of Health Sciences, Fernando Pessoa University, Rua Carlos da Maia, 296, P-4200-150 Porto, Portugal. Electronic address:
    Nanostructured lipid carriers (NLC) are well-known systems that show effectiveness to improve skin hydration, being suggested for cosmetic and dermatological use. Nonetheless, NLC dispersions present low viscosity, which is non-attractive for cutaneous application. To circumvent this drawback, the dispersions can be gelled or incorporated in semisolid systems, increasing the final formulation consistency. Read More

    Efficacy of a Skin Condition-Adapted Solution for Xerosis and Itch Relief Associated With Aging.
    J Drugs Dermatol 2016 Nov;15(11):s91-s94
    In recent decades, the stratum corneum (SC), has been recognized for its multifunctional role in maintaining the homeostasis of the human epidermal barrier. A better understanding of the SC's ability to act as its own biosensor in detecting dysfunction and integrating restorative actions can help identify the origin of certain skin conditions. A more holistic understanding of the morphological changes of the SC during the natural aging process and how it deviates in disease states can help bring about new treatment strategies. Read More

    Exogenous Factors in Skin Barrier Repair.
    J Drugs Dermatol 2016 Nov;15(11):1289-1294
    The stratum corneum (SC) is the skin's outermost layer and serves the primary function of acting as a shield to keep foreign matter out and to essential elements, such as moisture and water, in. Maintenance of this skin barrier is crucial to healthy functioning skin. A damaged or diseased skin barrier is vulnerable to infection, irritants, and allergens. Read More

    The effect of moisturizers or creams on scars: a systematic review protocol.
    JBI Database System Rev Implement Rep 2017 Jan;15(1):15-19
    1The Joanna Briggs Institute, Faculty of Health and Medical Sciences, The University of Adelaide, Australia 2Adult Burn Service, Royal Adelaide Hospital, Adelaide, Australia.
    Review Question/objective: The objectives of the review are to identify the effect of any moisturizers or creams (medicated or unmedicated) on immature scars (linear, keloid or hypertrophic) on any persons of any age. Effects will be assessed by changes in scar activity, changes in the final appearance/cosmesis of the scar, improvements in patient reported features of scars (e.g. Read More

    Role of Pregabalin in Management of Pruritus: A Literature Review.
    J Pharm Pharm Sci 2016 Oct - Dec;19(4):465-474
    Faculty of Pharmacy and Pharmaceutical Sciences, Kerman University of Medical Sciences, Kerman, Iran.
    Pruritus can be one of the distressing symptoms of many dermatologic, systemic, neurologic or psychiatric disorders. In each case, the origin of itch is in the skin and/or the nervous system. Involvement of the nervous system causes neurogenic, psychogenic or neuropathic itch. Read More

    Hormone Therapy and Other Treatments for Symptoms of Menopause.
    Am Fam Physician 2016 Dec;94(11):884-889
    Orlando, FL, USA.
    The results of large clinical trials have led physicians and patients to question the safety of hormone therapy for menopause. In the past, physicians prescribed hormone therapy to improve overall health and prevent cardiac disease, as well as for symptoms of menopause. Combined estrogen/progestogen therapy, but not estrogen alone, increases the risk of breast cancer when used for more than three to five years. Read More

    Cost-effectiveness of Prophylactic Moisturization for Atopic Dermatitis.
    JAMA Pediatr 2017 Feb 6;171(2):e163909. Epub 2017 Feb 6.
    Chicago Integrative Eczema Center, Chicago, Illinois.
    Importance: Emerging evidence suggests that the use of moisturizers on newborns and infants (ie, from birth to 6 months of age) is potentially helpful in preventing the development of atopic dermatitis.

    Objective: To investigate the cost-effectiveness of using a daily moisturizer as prevention against atopic dermatitis among high-risk newborns.

    Design, Setting, And Participants: In a cost-effectiveness analysis, the average cost of total-body moisturization using 7 common moisturizers from birth to 6 months of age was determined for male and female infants. Read More

    Association Between Infertility and Sexual Dysfunction in Men and Women.
    Sex Med Rev 2016 Oct 4;4(4):353-365. Epub 2016 Jun 4.
    Department of Urology, University of Miami-Miller School of Medicine, Miami, FL, USA. Electronic address:
    Introduction: The relation between infertility and sexual dysfunction can be reciprocal. Causes of sexual dysfunction that affect fertility include erectile dysfunction, Peyronie's disease (abnormal penile curvature), low libido, ejaculatory disorders in men, and genito-pelvic pain/penetration disorder (GPPPD) and low sexual desire in women.

    Aim: To review the association between infertility and sexual dysfunction and discuss current management strategies to address sexual disorders in couples with infertility. Read More

    Vaginal and sexual health treatment strategies within a female sexual medicine program for cancer patients and survivors.
    J Cancer Surviv 2017 Apr 21;11(2):274-283. Epub 2016 Nov 21.
    Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
    Purpose: We sought to evaluate patient adherence and response to simple vaginal and sexual health treatment strategies in female cancer patients receiving treatment at a female sexual medicine and health program and identify improvements of physical symptoms, per patient and clinical evaluation.

    Methods: Evaluability criteria included gynecologic exam at initial visit, at least one follow-up with gynecologic exam within 8 months of initial visit, and all consecutive follow-ups <6 months apart. Demographics, medical information, and clinical assessments from 175 evaluable patients with at least one follow-up from 09/12 to 10/14 were analyzed. Read More

    Effectiveness of interventions for preventing occupational irritant hand dermatitis: a quantitative systematic review protocol.
    JBI Database System Rev Implement Rep 2016 Oct;14(10):72-81
    1The Scottish Centre for Evidence-based, Multi-professional Practice: a Joanna Briggs Institute Centre of Excellence, Aberdeen, United Kingdom 2Robert Gordon University, Aberdeen, United Kingdom 3National Health Service Grampian, Aberdeen, United Kingdom.
    Review Question/objective: The objective of this quantitative systematic review is to identify, appraise and synthesize the best available evidence on the effectiveness of moisturizers, barrier creams, protective gloves, skin protection education and complex interventions (a combination of two or more of the interventions listed) in preventing occupational irritant hand dermatitis (OIHD) in wet workers. These interventions will be compared to an alternative intervention or to usual care (workers regular skin care regime). The specific review question is: "What is the effectiveness of moisturizers, barrier creams, protective gloves, skin protection education and complex interventions in preventing OIHD in wet workers?" Read More

    Rosacea Management.
    Skin Appendage Disord 2016 Sep 18;2(1-2):26-34. Epub 2016 May 18.
    Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Winston-Salem, N.C., USA.
    Background: Rosacea is a chronic inflammatory skin condition associated with four distinct subtypes: erythematotelangiectatic, papulopustular, phymatous, and ocular.

    Purpose: To review the different kinds of management for all subtypes.

    Methods: We divided rosacea management into three main categories: patient education, skin care, and pharmacological/procedural interventions. Read More

    Clinical update on the use of ospemifene in the treatment of severe symptomatic vulvar and vaginal atrophy.
    Int J Womens Health 2016 26;8:617-626. Epub 2016 Oct 26.
    Gynecology and Obstetrics Department, Guadalajara University Hospital, University of Alcalá, Spain.
    The physiological decrease in vaginal estrogens is accountable for the emergence of vulvar and vaginal atrophy (VVA) and its related symptoms such as vaginal dryness, dyspareunia, vaginal and/or vulvar irritation or itching, and dysuria. The repercussion of these symptoms on quality of life often makes it necessary to initiate treatment. Up until now, the treatments available included vaginal moisturizers and lubricants, local estrogens, and hormonal therapy. Read More

    Alkyl Glucosides in Contact Dermatitis.
    Dermatitis 2017 Jan/Feb;28(1):5-13
    From the *Division of Dermatology, McGill University Health Centre, Montreal, Quebec, Canada, †Division of Dermatology, National Guard Hospital, Riyadh, Saudi Arabia; and ‡Service de Dermatologie, Centre Hospitalier Universitaire Estaing, Clermont-Ferrand, France.
    Ecologically sound because they are synthesized from natural and renewable sources, the mild surfactants alkyl glucosides are being rediscovered by the cosmetic industry. They are currently found in rinse-off products such as shampoos, liquid cleansers, and shower gels, but also in leave-on products that include moisturizers, deodorants, and sunscreens. During the past 15 years, numerous cases of allergic contact dermatitis have been published, mostly to lauryl and decyl glucosides, and these compounds are considered emergent allergens. Read More

    Impact of Types of Moisturizer and Humidity on the Residual Weight and Viscosity of Liquid and Gel Oral Moisturizers.
    J Prosthodont 2016 Oct 16;25(7):570-575. Epub 2015 Sep 16.
    Department of Oral and Maxillofacial Prosthodontics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
    Purpose: Oral moisturizers need to be selected based on their material properties. The purpose of this study was to investigate the effects of moisturizer type and humidity on the residual weight and viscosity of oral moisturizers.

    Materials And Methods: The weight and viscosity of 17 oral moisturizers (7 liquid and 10 gel) at baseline and after 8 hours were measured using an incubator maintained at 37°C at either 85% or 40% relative humidity (RH). Read More

    Stratum Corneum Abnormalities and Disease-Affected Skin: Strategies for Successful Outcomes in Inflammatory Acne.
    J Drugs Dermatol 2016 Oct;15(10):1170-1173
    Stratum corneum (SC) abnormalities are associated with disease-affected skin conditions such as inflammatory acne. Current topical acne treatment options including benzoyl peroxide and retinoids can worsen the barrier dysfunctions by increasing transepidermal water loss, depleting SC vitamin E levels, and relatively decreasing SC thickness. However, strategies exist to employ these treatments in a more effective manner and lessen barrier function disruption including use of less irritating vehicles or concomitant application of moisturizers. Read More

    Severe pruritus · Crusted lesions affecting face, extremities, and trunk · Hepatitis C virus carrier · Dx?
    J Fam Pract 2016 Aug;65(8):E1-3
    Department of Dermatology, Istanbul Medeniyet University School of Medicine, Göztepe Training and Research Hospital, Turkey.
    The patient had visited various clinics for her complaints and was diagnosed as having contact dermatitis and senile pruritus. She was prescribed topical mometasone furoate and moisturizers. After 6 months of using this therapy, widespread grey-white plaques and minimal excoriation appeared on her face, scalp, and trunk. Read More

    Impact of Contraception on Female Sexual Function.
    J Womens Health (Larchmt) 2017 Mar 13;26(3):207-213. Epub 2016 Sep 13.
    3 Women's Health Clinic, Division of General Internal Medicine, Mayo Clinic , Rochester, Minnesota.
    Background: Sexual dysfunction is common among US women of reproductive age, many of whom use contraception. Various contraceptive methods have been associated with changes in sexual function.

    Methods: In this narrative review, we selected key articles based on our collective clinical experience. Read More

    Skin Barrier Health: Regulation and Repair of the Stratum Corneum and the Role of Over-the-Counter Skin Care.
    J Drugs Dermatol 2016 Sep;15(9):1047-51
    The epidermis functions as a physical barrier that separates the inner body from the outside environment. The outermost layer of the epidermis, the stratum corneum, plays a key role in maintaining this barrier. There are numerous biochemical changes that take place to and in the keratinocyte as it migrates from the bottom, or startum basale, to the top layer of the epidermis in order for this barrier to function appropriately. Read More

    What's new in the world of postmenopausal sex?
    Curr Opin Obstet Gynecol 2016 Oct;28(5):449-54
    aSection of Female Pelvic Medicine and Reconstructive Surgery, MedStar Washington Hospital Center bDepartments of Obstetrics & Gynecology and Urology, Georgetown University School of Medicine, Washington, District of Columbia, USA.
    Purpose Of Review: The purpose of this review is to describe new terminology for vulvovaginal atrophy and female sexual dysfunction and to highlight recent findings related to vaginal moisturizers, lubricants and prescription estrogen preparations.

    Recent Findings: Sexual health is a marker for overall health. A minority (40%) of healthcare providers routinely ask about sexual problems and its impact on quality of life. Read More

    Noninvasive Facial Rejuvenation. Part 3: Physician-Directed-Lasers, Chemical Peels, and Other Noninvasive Modalities.
    Semin Plast Surg 2016 Aug;30(3):143-50
    Nigro Dermatology Group, Houston, Texas.
    A proper knowledge of noninvasive facial rejuvenation is integral to the practice of a cosmetic surgeon. Noninvasive facial rejuvenation can be divided into patient- versus physician-directed modalities. Patient-directed facial rejuvenation combines the use of facial products such as sunscreen, moisturizers, retinoids, α-hydroxy acids, and various antioxidants to both maintain youthful skin and rejuvenate damaged skin. Read More

    Noninvasive Facial Rejuvenation. Part 2: Physician-Directed-Neuromodulators and Fillers.
    Semin Plast Surg 2016 Aug;30(3):134-42
    Nigro Dermatology Group, Houston, Texas.
    A proper knowledge of noninvasive facial rejuvenation is integral to the practice of a cosmetic surgeon. Noninvasive facial rejuvenation can be divided into patient- versus physician-directed modalities. Patient-directed facial rejuvenation combines the use of facial products such as sunscreen, moisturizers, retinoids, α-hydroxy acids, and various antioxidants to both maintain youthful skin as well as rejuvenate damaged skin. Read More

    Noninvasive Facial Rejuvenation. Part 1: Patient-Directed.
    Semin Plast Surg 2016 Aug;30(3):129-33
    Division of Plastic Surgery, Baylor College of Medicine, Houston, Texas.
    A proper knowledge of noninvasive facial rejuvenation is integral to the practice of a cosmetic surgeon. Noninvasive facial rejuvenation can be divided into patient- versus physician-directed modalities. Patient-directed facial rejuvenation combines the use of facial products such as sunscreen, moisturizers, retinoids, α-hydroxy acids, and various antioxidants to both maintain youthful skin and rejuvenate damaged skin. Read More

    Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    Am J Obstet Gynecol 2016 Dec 26;215(6):704-711. Epub 2016 Jul 26.
    Department of Physiology and Biophysics, Stony Brook University School of Medicine, Stony Brook, NY; Department of Urology, Stony Brook University School of Medicine, Stony Brook, NY. Electronic address:
    Genitourinary syndrome of menopause, a new term for a condition more renowned as atrophic vaginitis, is a hypoestrogenic condition with external genital, urological, and sexual implications that affects >50% of postmenopausal women. Due to sexual embarrassment and the sensitive nature of discussing symptoms, genitourinary syndrome of menopause is greatly underdiagnosed. The most up-to-date literature pertaining to clinical manifestations, pathophysiology, etiology, evaluation, and management of genitourinary syndrome of menopause is comprehensively reviewed. Read More

    Meeting the Challenges of Acne Treatment in Asian Patients: A Review of the Role of Dermocosmetics as Adjunctive Therapy.
    J Cutan Aesthet Surg 2016 Apr-Jun;9(2):85-92
    Dr SN Wong Skin, Hair, Nails and Laser Specialist Clinic, Mt Elizabeth Medical Centre, Singapore.
    Conventional acne treatment presents several challenges such as intolerable side effects and antibiotic resistance. Dermocosmetic products may be used to reduce these unwanted effects. Dermocosmetics include skin cleansers, topical sebum-controllers, skin antimicrobial/anti-inflammatory agents, moisturizers, sunscreens, and camouflage products. Read More

    Design, synthesis and characterization of linear unnatural amino acids for skin moisturization.
    Int J Cosmet Sci 2017 Feb 24;39(1):72-82. Epub 2016 Jul 24.
    MedPharm Ltd., 50 Occam Road, Surrey Buisness Park, Guildford, GU2 7AB, UK.
    Objectives: This work aimed to design, synthesize and characterize replacement natural moisturizing factor (NMF) composed of modified hygroscopic linear amino acids to pre-empt or repair skin barrier dysfunction.

    Methods: Following synthesis and characterization, thermo-gravimetric analysis and quantum mechanics molecular modelling quantified and depicted water binding to the new compounds. Deliquescence relative humidity demonstrated the water-scavenging ability of the compounds, whereas snake skin moisturizing studies showed they increased water uptake into snake skin. Read More

    Analysis of absorption and spreading of moisturizer on the microscopic region of the skin surface with near-infrared imaging.
    Skin Res Technol 2016 Nov 23;22(4):505-512. Epub 2016 Jun 23.
    Shiseido Research Center, Yokohama, Japan.
    Background/purpose: Near-infrared (NIR) light with high water absorption enables us to visualize the water content distribution appeared in the superficial skin layer. The light penetration depth with the wavelength of 1920 nm is almost 100 μm from the skin surface. Thus, the water distribution in the stratum corneum can be effectively imaged by detecting the wavelength band around 1920 nm. Read More

    Liquid Crystal Formation from Sunflower Oil: Long Term Stability Studies.
    Molecules 2016 Jun 9;21(6). Epub 2016 Jun 9.
    Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café, s/n. Bairro Monte Alegre, Ribeirão Preto, SP 14040-903, Brazil.
    The Brazilian biodiversity offers a multiplicity of raw materials with great potential in cosmetics industry applications. Some vegetable oils and fatty esters increase skin hydration by occlusivity, keeping the skin hydrated and with a shiny appearance. Sunflower (Helianthus annus L. Read More

    Moisturizers: The Slippery Road.
    Indian J Dermatol 2016 May-Jun;61(3):279-87
    Department of Skin and S.T.D, GMC, Amritsar, Punjab, India.
    Moisturizers are an important part of a dermatologist's armamentarium although little is written and well, a less is truly known about them. There is a cornucopia of projected skin products in the market whose real scientific role is not proven. These products although at times are regarded as mere cosmetics but have a well-known role in many skin disorders. Read More

    CSP0510 Lotion as a Novel Moisturizer Containing Citric Acid and Trisodium Phosphate Relieves Objective and Subjective Symptoms of Atopic Dermatitis.
    Ann Dermatol 2016 Jun 25;28(3):344-51. Epub 2016 May 25.
    Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
    Background: Moisturizers with anti-inflammatory or anti-itch activity should be developed for the safe and effective management of atopic dermatitis (AD).

    Objective: This study evaluated the efficacy of a newly developed moisturizer, CSP0510 lotion (Twolines Inc., Korea), containing citric acid (CA) and trisodium phosphate (TSP) as active ingredients, in mild to moderate AD. Read More

    Volatile methylsiloxanes in personal care products - Using QuEChERS as a "green" analytical approach.
    Talanta 2016 Aug 16;155:94-100. Epub 2016 Apr 16.
    LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
    Organosiloxanes, namely volatile methylsiloxanes (VMSs) are one of the most relevant classes of ingredients incorporated in personal care products (PCPs), such as creams and lotions, bath soaps and hair care products. Their use has caused concern among the scientific community due to their potential toxic behaviour to human health and environment. This manuscript reports the first application of QuEChERS ("Quick, Easy, Cheap, Effective, Rugged and Safe") extraction followed by gas chromatography - mass spectrometry analysis to determine VMSs in cosmetics and personal care products. Read More

    A review on the role of moisturizers for atopic dermatitis.
    Asia Pac Allergy 2016 Apr 28;6(2):120-8. Epub 2016 Apr 28.
    Department of Pediatrics and Adolescent Medicine, United Christian Hospital, Kwun Tong, Hong Kong.
    Effective management of atopic dermatitis (AD) involves the treatment of a defective skin barrier. Patients with AD are therefore advised to use moisturizers regularly. To date, there are few comparative studies involving moisturizers in patients with AD, and no classification system exists to objectively determine which types of moisturizers are best suited to specific AD phenotypes. Read More

    Analysis of the Stability of External-Application Dermatologic Preparations: Consideration from Rheological Measurements.
    Chem Pharm Bull (Tokyo) 2016 Jul 22;64(7):1047-55. Epub 2016 Apr 22.
    Faculty of Pharmaceutical Sciences, Teikyo Heisei University.
    The present study examined the stability of mixtures of various combinations of moisturizers, water in oil (w/o)-type or oil in water (o/w)-type cream preparations containing heparinoids, and steroidal ointments or creams (o/w-type) frequently used in children. Centrifugation at room temperature led to separation of mixtures of w/o-type moisturizers and steroidal ointments into three layers. Polarized microscopic observations, near-infrared (NIR) spectroscopy, and dye-based analyses revealed the presence of oily components in the upper and middle layers and water-soluble components in the lower layer. Read More

    From the shop to the drain - Volatile methylsiloxanes in cosmetics and personal care products.
    Environ Int 2016 Jul-Aug;92-93:50-62. Epub 2016 Apr 5.
    LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
    Organosiloxanes are widely used in the formulation of a broad range of cosmetic and personal care products (PCPs), including creams and lotions, bath soaps, shampoo and hair care products to soften, smooth, and moisten. In fact, the intensive and widespread use of organosiloxanes combined with their lipophilic nature, makes them interesting targets for future research, particularly in the toxicology area. This study focused on determining the concentration levels of these compounds in the bestselling brands of PCPs in the Oporto region (Portugal), allowing the estimation of dermal and inhalation exposure to siloxanes and the evaluation of the quantities released to the environment "down-the-drain" and to air. Read More

    Pessary Practices of Nurse-Providers in the United States.
    Female Pelvic Med Reconstr Surg 2016 Jul-Aug;22(4):261-6
    From the *Division of Pelvic Medicine and Reconstructive Surgery, University of Massachusetts Memorial Medical Center, Worcester, MA; †Division of Urogynecology and Reconstructive Pelvic Surgery, Parkland Health & Hospital System, and The University of Texas Southwestern Medical Center, Dallas TX; ‡Capstone College of Nursing, The University of Alabama, Tuscaloosa, AL; and §Department of OB/GYN, University of Massachusetts Medical School, Worcester MA.
    Objectives: Our purposes were to describe pessary-care practices and education of a sample of nurse providers in the United States and identify a cohort of high-volume providers.

    Methods: An e-mail survey was sent to members of 3 related nursing professional organizations. Questions addressed general pessary care within the respondent's practice and specific pessary care choices of responding direct providers. Read More

    Clinical studies in dermatology require a post-treatment observation phase to define the impact of the intervention on the natural history of the complaint.
    Arch Dermatol Res 2016 Aug 30;308(6):379-87. Epub 2016 Mar 30.
    Unilever Research & Development, Shanghai, People's Republic of China.
    The use of a post-treatment period of observation or "regression phase" is common in pharmaceutical and cosmetic clinical dermatology studies. Regression phases can be incorporated into a variety of study designs, ranging from simple post-treatment observation for a defined period, as has been used for moisturizers, antidandruff formulations, and treatments for acne, to more complex randomized intermittent-treatment designs, as used in studies of psoriasis pharmacotherapies. Extensive information can be derived from a regression phase. Read More

    Therapies to improve the cosmetic symptoms of atopic dermatitis.
    Cutis 2016 Mar;97(3):183-6
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
    Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease. The cosmetic symptoms of AD can have a serious impact on a patient's quality of life. Although there currently is no cure for AD, treatment is aimed at relieving its symptoms and preventing acute exacerbations as well as improving cosmetic appearance to enhance quality of life. Read More

    Atopic dermatitis: recent insight on pathogenesis and novel therapeutic target.
    Asian Pac J Allergy Immunol 2016 Jun;34(2):98-108
    Department of Pediatrics, San Paolo Hospital, Department of Health Sciences, University of Milan,Italy.
    Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. It affects infancy, but it is also highly prevalent in adults and it is one of the disease burdens for the patients and their families. Nowadays, AD is recognized as a heterogenous disease with different subtypes with variable clinical manifestations which is affected by the impairments of the skin barrier. Read More

    Frontal fibrosing alopecia: possible association with leave-on facial skin care products and sunscreens; a questionnaire study.
    Br J Dermatol 2016 Oct 30;175(4):762-7. Epub 2016 Jun 30.
    Department of Dermatology, Royal Hallamshire Hospital, Sheffield, S10 2JF, U.K..
    Background: Since its first description in 1994, frontal fibrosing alopecia (FFA) has become increasingly common, suggesting that environmental factors are involved in the aetiology.

    Objectives: To identify possible causative environmental factors in FFA.

    Methods: A questionnaire enquiring about exposure to a wide range of lifestyle, social and medical factors was completed by 105 women with FFA and 100 age- and sex-matched control subjects. Read More

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