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    Significance of Skin Barrier Dysfunction in Atopic Dermatitis.
    Allergy Asthma Immunol Res 2018 May;10(3):207-215
    Department of Pediatrics, National Jewish Health, Denver, CO, USA.
    The epidermis contains epithelial cells, immune cells, and microbes which provides a physical and functional barrier to the protection of human skin. It plays critical roles in preventing environmental allergen penetration into the human body and responsing to microbial pathogens. Atopic dermatitis (AD) is the most common, complex chronic inflammatory skin disease. Read More

    Dermatologic Toxicity Occurring During Anti-EGFR Monoclonal Inhibitor Therapy in Patients With Metastatic Colorectal Cancer: A Systematic Review.
    Clin Colorectal Cancer 2017 Dec 13. Epub 2017 Dec 13.
    Jefferson University Hospitals, Philadelphia, PA.
    Monoclonal antibody inhibitors of the epidermal growth factor receptor (EGFR) have been shown to improve outcomes for patients with metastatic colorectal cancer (mCRC) without RAS gene mutations. However, treatment with anti-EGFR agents can be associated with toxicities of the skin, nails, hair, and eyes. Because these dermatologic toxicities can result in treatment discontinuation and affect patient quality of life, their management is an important focus when administering anti-EGFR monoclonal antibodies. Read More

    Vaginal health and hygiene practices and product use in Canada: a national cross-sectional survey.
    BMC Womens Health 2018 Mar 23;18(1):52. Epub 2018 Mar 23.
    Department of Psychology, University of Guelph, 50 Stone Road E, Guelph, Ontario, N1G 2W1, Canada.
    Background: The vaginal microbiome influences quality of life and health. The composition of vaginal microbiota can be affected by various health behaviors, such as vaginal douching. The purpose of this study was to examine the types and prevalence of diverse vaginal/genital health and hygiene behaviors among participants living in Canada and to examine associations between behavioral practices and adverse gynecological health conditions. Read More

    Deriving a water quality guideline for protection of aquatic communities exposed to triclosan in the Canadian environment.
    Integr Environ Assess Manag 2018 Mar 12. Epub 2018 Mar 12.
    Colgate-Palmolive Company, New York, New York, USA.
    Triclosan is an antibacterial and antifungal chemical used in a variety of consumer products including soaps, detergents, moisturizers, and cosmetics. Aquatic ecosystems may be exposed to triclosan following the release of remaining residues in wastewater effluents and biosolids. In December of 2017, Environment and Climate Change Canada (ECCC) released a Federal Environmental Quality Guideline (FEQG) report that contained a Federal Water Quality Guideline (FWQG) for triclosan. Read More

    Beyond the physico-chemical barrier: Glycerol and xylitol markedly yet differentially alter gene expression profiles and modify signalling pathways in human epidermal keratinocytes.
    Exp Dermatol 2018 Mar;27(3):280-284
    Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
    Polyols (e.g. glycerol, xylitol) are implicated as moisturizers of the skin and other epithelial tissues. Read More

    Parental confusion may result when primary health care professionals show heterogeneity in their knowledge, attitudes, and perceptions regarding infant nutrition, food allergy, and atopic dermatitis.
    Allergol Immunopathol (Madr) 2018 Feb 26. Epub 2018 Feb 26.
    PEDEGO Research Unit and MRC Oulu, University of Oulu and Oulu University Hospital, P.O. Box 5000, FIN 90014 Oulu, Finland; Biomedicine Research Unit, Medical Microbiology and Immunology, University of Oulu, P.O. Box 5000, FIN 90014 Oulu, Finland.
    Introduction And Objectives: Whether the guidelines on infant nutrition, food allergy and atopic dermatitis confer real health benefits in practice at the population level has not been deeply studied. We aimed here to characterize the knowledge, attitudes, and perceptions regarding these issues among primary health care professionals. In addition, we surveyed available parent-reported information sources and the incidence of food-related symptoms, dietary restrictions, food allergy, and atopic dermatitis among one-year-old children in the general population. Read More

    Quality of Life, Behaviour and Attitudes towards Actinic Keratosis in Spain: The PIQA Study.
    Actas Dermosifiliogr 2018 Feb 21. Epub 2018 Feb 21.
    Instituto Valenciano de Oncología, Valencia, España. Electronic address:
    Objective: This study was aimed to examine patients' knowledge, behaviours and attitudes regarding actinic keratosis (AK) lesions and the impact of the disease on patients' quality of life (QoL).

    Methods: Observational study of patients with AK lesions in Spain. QoL was evaluated with the validated version of Spanish AKQoL questionnaire. Read More

    A Nonsteroidal Novel Formulation Targeting Inflammatory and Pruritus-Related Mediators Modulates Experimental Allergic Contact Dermatitis.
    Dermatol Ther (Heidelb) 2018 Mar 16;8(1):111-126. Epub 2018 Feb 16.
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
    Introduction: A major clinical challenge in treating allergic contact dermatitis (ACD) is that the first line of treatment is based on the use of corticosteroids. In this study, we aimed to develop a formulation that is devoid of steroids.

    Methods: We used mouse ears treated with dinitrofluorobenzene (DNFB) to induce ACD. Read More

    Management of Menopausal Symptoms for Women Who Are at High Risk of Thrombosis.
    Clin Obstet Gynecol 2018 Feb 6. Epub 2018 Feb 6.
    Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina.
    For women at elevated risk of thrombosis, clinicians are challenged to relieve menopausal symptoms without increasing the risk of thrombosis. Oral menopausal hormone therapy increases the risk of venous thromboembolism by 2-fold to 3-fold. Observational studies suggest less thrombotic risk with transdermal therapies and with progesterone over synthetic progestogens (progestins), but the data are limited. Read More

    Comparison of linoleic acid-containing water-in-oil emulsion with urea-containing water-in-oil emulsion in the treatment of atopic dermatitis: a randomized clinical trial.
    Clin Cosmet Investig Dermatol 2018 5;11:21-28. Epub 2018 Jan 5.
    Center for Research and Training in Skin Diseases and Leprosy.
    Background: Application of topical moisturizers is an essential part of the management of atopic dermatitis (AD). Linoleic acid (LA), the most abundant fatty acid in the epidermis, and its derivatives have an essential role in the structure and function of the epidermal barrier, and their defects are prominent in AD. The aim of this study was to compare the efficacy and safety of two cosmetic products containing either LA or urea in patients with AD. Read More

    Evidence-based treatment of atopic dermatitis with topical moisturizers.
    G Ital Dermatol Venereol 2018 Jan 24. Epub 2018 Jan 24.
    Dermatology Clinic, University of Catania, Catania, Italy -
    Skin barrier restoration represents the mainstay of the treatment of atopic dermatitis and the use of moisturizers is recommended by several international guidelines. The aim of the study was to investigate through an evidence-based medicine analysis the effectiveness and safety of different moisturizing products available for a non-pharmacological treatment of atopic dermatitis. A total of 92 randomized controlled trials (RCTs) have been identified and analyzed. Read More

    The Use of an Over-the-Counter Hand Cream With Sweet Almond Oil for the Treatment of Hand Dermatitis.
    J Drugs Dermatol 2018 Jan;17(1):78-82
    Hand dermatitis is estimated to affect greater than 15% of the general population. Childhood eczema, frequent hand washing, and occupational exposure to chemicals are predisposing factors. Hand dermatitis treatment involves both prevention of outbreaks and treatment of active disease. Read More

    The science behind skin care: Moisturizers.
    J Cosmet Dermatol 2018 Apr 10;17(2):138-144. Epub 2018 Jan 10.
    Dermatology Consulting Services, PLLC, High Point, NC, USA.
    Moisturizers provide functional skin benefits, such as making the skin smooth and soft, increasing skin hydration, and improving skin optical characteristics; however, moisturizers also function as vehicles to deliver ingredients to the skin. These ingredients may be vitamins, botanical antioxidants, peptides, skin-lightening agents, botanical anti-inflammatories, or exfoliants. This discussion covers the science of moisturizers. Read More

    Management of Itch in Atopic Dermatitis.
    Am J Clin Dermatol 2017 Dec 28. Epub 2017 Dec 28.
    Department of Dermatology and Itch Center, University of Miami Miller School of Medicine, Miami, FL, USA.
    Atopic dermatitis (AD) is the most common itchy dermatosis that affects millions of children and adults worldwide. Chronic itch in this condition has significant impact on measures of quality of life, such as sleep. Treating itch in AD has been challenging for decades, but new drugs have emerged in the last year with significant anti-pruritic effect. Read More

    The science behind skin care: Cleansers.
    J Cosmet Dermatol 2018 Feb 12;17(1):8-14. Epub 2017 Dec 12.
    Dermatology Consulting Services, PLLC, High Point, NC, USA.
    Two of the most important skin care categories with profound dermatologic implications are cleansers and moisturizers. Cleansers are composed of alkaline soaps or the less barrier-damaging synthetic detergents, known as syndets. The lower skin irritation and dryness found with syndets are related to their reduced tendency to cause protein denaturation due to the charge density of protein-bound micelle-like surfactant aggregates. Read More

    The Role of Moisturizers in Addressing Various Kinds of Dermatitis: A Review.
    Clin Med Res 2017 Dec 11;15(3-4):75-87. Epub 2017 Dec 11.
    Politeknik Kesehatan Jakarta, Indonesia.
    Moisturizer is a major component of basic daily skin care, particularly in presence of epidermal barrier alteration and reduced epidermal water content. It is an important part of a dermatologist's strategy to maintain skin health as well as treating various dermatoses which co-exist with skin dryness and are linked to impaired skin barrier function, such as in atopic disorders as well as other types of dermatitis. Mastering the knowledge regarding mechanism of action, application, dosage, adverse effects as well as specific clinical usage of moisturizers is a must for a dermatologist in order to support their use, particularly for evidence-based, therapeutic purposes. Read More

    Interventions to Address Sexual Problems in People With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Adaptation of Cancer Care Ontario Guideline.
    J Clin Oncol 2018 Feb 11;36(5):492-511. Epub 2017 Dec 11.
    Jeanne Carter, Katherine DuHamel, and Shari Goldfarb, Memorial Sloan Kettering Cancer Center, New York; Michael A. Diefenbach, Northwell Health, Manhasset, NY; Christina Lacchetti, American Society of Clinical Oncology, Alexandria; Sage Bolte, Inova, Fairfax, VA; Barbara L. Andersen, Ohio State University, Columbus, OH; Debra L. Barton, University of Michigan, Ann Arbor, MI; Shari Damast, Yale School of Medicine, New Haven, CT; Judith Florendo, Florendo Physical Therapy, Chicago; Sigrun Hallmeyer, Oncology Specialists SC, Park Ridge, IL; Patricia A. Ganz, University of California, Los Angeles, CA; David M. Kushner, University of Wisconsin, Madison, WI; and Julia H. Rowland, National Cancer Institute, Bethesda, MD.
    Purpose The adaptation of the Cancer Care Ontario (CCO) guideline Interventions to Address Sexual Problems in People With Cancer provides recommendations to manage sexual function adverse effects that occur as a result of cancer diagnosis and/or treatment. Methods ASCO staff reviewed the guideline for developmental rigor and updated the literature search. An ASCO Expert Panel ( Table A1 ) was assembled to review the guideline content and recommendations. Read More

    Genitourinary Syndrome of Menopause: Management Strategies for the Clinician.
    Mayo Clin Proc 2017 Dec;92(12):1842-1849
    Women's Health Clinic, Division of General Internal Medicine, Mayo Clinic, Rochester, MN; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN.
    Genitourinary syndrome of menopause (GSM), previously known as atrophic vaginitis or vulvovaginal atrophy, affects more than half of postmenopausal women. Caused by low estrogen levels after menopause, it results in bothersome symptoms, including vaginal dryness, itching, dyspareunia, urinary urgency and increased frequency, and urinary tract infections. Even though women with GSM can have sexual dysfunction that interferes with partner relationships, women are often embarrassed to seek treatment, and health care professionals do not always actively screen for GSM. Read More

    A starch, glycyrretinic, zinc oxide and bisabolol based cream in the treatment of chronic mild-to-moderate atopic dermatitis in children: a three-center, assessor blinded trial.
    Minerva Pediatr 2017 Dec;69(6):470-475
    Pediatric Clinic San Matteo Hospital, University of Pavia, Pavia, Italy.
    Background: Atopic dermatitis (AD) is a very common chronic inflammatory and eczematous skin condition characterized by flares and remissions. Skin barrier alteration or dysfunction is the most relevant patogenetic factor. Topical corticosteroids are the mainstay treatment of AD, especially during flare periods. Read More

    Economic assessment of actual prescription of drugs for treatment of atopic dermatitis: Differences between dermatology and pediatrics in large-scale receipt data.
    J Dermatol 2018 Feb 23;45(2):165-174. Epub 2017 Nov 23.
    Department of Bio-Environmental Response, Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
    Using large-scale receipt data, we analyzed the differences in the prescription of drugs and their costs between dermatology and pediatrics in the treatment of atopic dermatitis (AD) in children. Between August 2010 and July 2011, 50 706 patients were diagnosed as having AD, and the data of 21 075 (15 257 dermatology, 5818 pediatric) patients aged 0-14 years were included in this study. The use of classes I (strongest), II (very strong), and III (strong) topical corticosteroids and tacrolimus was significantly higher in dermatology than in pediatrics (class I, 2. Read More

    The pH of the main Brazilian commercial moisturizers and liquid soaps: considerations on the repair of the skin barrier.
    An Bras Dermatol 2017 Sep-Oct;92(5):736-738
    Department of Dermatology of Medical School of Botucatu - Universidade Estadual Paulista "Júlio de Mesquita Filho" (FMB-UNESP) - Botucatu (SP), Brazil.
    The pH of the skin is slightly acidic (4.6 to 5.8) which is important for appropriate antibacterial, antifungal, constitution of barrier function, as well as structuring and maturation of the stratum corneum. Read More

    Management of Plantar Keratodermas.
    J Am Podiatr Med Assoc 2017 Sep;107(5):428-435
    Plantar keratodermas can arise due to a variety of genetically inherited mutations. The need to distinguish between different plantar keratoderma disorders is becoming increasingly apparent because there is evidence that they do not respond identically to treatment. Diagnosis can be aided by observation of other clinical manifestations, such as palmar keratoderma, more widespread hyperkeratosis of the epidermis, hair and nail dystrophies, or erythroderma. Read More

    Non-Prescription Treatment Options.
    Adv Exp Med Biol 2017 ;1027:121-137
    Department of Dermatology, Emory School of Medicine, Atlanta, GA, USA.
    The pathogenesis of atopic dermatitis (AD) is complex and multifactorial. However, recent advancements in the genetics and pathophysiology of AD suggest that epidermal barrier dysfunction is paramount in the development and progression of the condition (Boguniewicz and Leung, Immunol Rev 242(1):233-246, 2011). In addition to standard therapy for AD, there are a plethora of non-prescription treatment modalities which may be employed. Read More

    The promise of marine molecules as cosmetic active ingredients.
    Int J Cosmet Sci 2018 Feb 4;40(1):1-15. Epub 2017 Dec 4.
    School of Marine Science and Technology, Newcastle University, Ridley Building 2, Newcastle upon Tyne, NE1 7RU, U.K.
    The marine environment represents an underexploited resource for the discovery of novel products, despite its high level of biological and chemical diversity. With increasing awareness of the harmful effects of chronic ultraviolet exposure, and a universal desire to improve cosmetic appearance, the market for new cosmetic ingredients is growing, and current trends have generated a greater demand for products sourced from the environment. A growing number of novel molecules from marine flora and fauna exhibit potent and effective dermatological activities. Read More

    Efficacy of the combined use of a mild foaming cleanser and moisturizer for the care of infant skin.
    Clin Cosmet Investig Dermatol 2017 3;10:393-401. Epub 2017 Oct 3.
    Department of Dermatology, Kanagawa Children's Medical Center, Yokohama, Japan.
    Objective: Despite the application of skin care treatments, many infants have skin problems such as dryness and erythema. We proposed a new combination skin care for infants which consisted of a foaming cleanser with lower surfactant activity and moisturizers that contained pseudo-ceramide.

    Subjects And Methods: A total of 50 infants (age: 3-24 months) with insignificant levels of dry skin were enrolled in this usage trial. Read More

    Ospemifene: A Novel Option for the Treatment of Vulvovaginal Atrophy.
    J Menopausal Med 2017 Aug 31;23(2):79-84. Epub 2017 Aug 31.
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
    Ospemifene-a third-generation selective estrogen receptor modulator approved by the Food and Drug Administration in 2013-is an oral medication for the treatment of dyspareunia. In postmenopausal women with vulvovaginal atrophy, ospemifene significantly improves the structure and pH levels of the vagina, reducing dyspareunia. It is available as a 60-mg tablet; hence, women who may have had prior difficulty with vaginal administration or on-demand use of nonprescription lubricants and moisturizers would likely prefer this form of treatment. Read More

    Dermopathy associated with cetuximab and panitumumab: investigation of the usefulness of moisturizers in its management.
    Clin Cosmet Investig Dermatol 2017 11;10:353-361. Epub 2017 Sep 11.
    Department of Geriatric and Environmental Dermatology.
    Aims: Limited data regarding the objective evaluation of skin exsiccation caused by epidermal growth factor receptor (EGFR) inhibitors exist. Objective indices were applied to evaluate the usefulness of a moisturizer against skin exsiccation associated with the use of EGFR inhibitors in cancer patients.

    Patients And Methods: Patients with either colorectal or head and neck cancer treated with either cetuximab or panitumumab were randomly assigned 1:2 to the prophylactic-treatment arm, where participants received prophylactical moisturizer treatment (heparinoid preparation, Hirudoid), or to the symptomatic-treatment arm, where moisturizer was applied after the onset of cutaneous symptoms. Read More

    Atopic dermatitis: skin care and topical therapies.
    Semin Cutan Med Surg 2017 Sep;36(3):104-110
    Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, California, USA.
    Atopic dermatitis (AD) pathogenesis is strongly influenced by Type 2 innate lymphoid cell and T-helper cell type 2 lymphocyte-driven inflammation and skin barrier dysfunction. AD therapies attempt to correct this pathology, and guidelines suggest suggest basics of AD therapy, which include repair of the skin barrier through bathing practices and moisturizers, infection control, and further lifestyle modifications to avoid and reduce AD triggers.While some patients' AD may be controlled using these measures, inflammatory eczema including acute flares and maintenance therapy in more severe patients are treated with topical pharmacologic agents such as topical corticosteroids, topical calcineurin inhibitors, and, more recently, topical PDE-4 inhibitors. Read More

    Consumer Preferences, Product Characteristics, and Potentially Allergenic Ingredients in Best-selling Moisturizers.
    JAMA Dermatol 2017 Nov;153(11):1099-1105
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
    Importance: Because moisturizer use is critical for the prevention and treatment of numerous dermatological conditions, patients frequently request product recommendations from dermatologists.

    Objective: To determine the product performance characteristics and ingredients of best-selling moisturizers.

    Design And Setting: This cohort study involved publicly available data of the top 100 best-selling whole-body moisturizing products at 3 major online retailers (Amazon, Target, and Walmart). Read More

    Quantitation of 24-Hour Moisturization by Electrical Measurements of Skin Hydration.
    J Wound Ostomy Continence Nurs 2017 Sep/Oct;44(5):487-491
    R. Randall Wickett, PhD, James L. Winkle College of Pharmacy, Cincinnati, Ohio. Bronson Damjanovic, BS, Coloplast Corporation, Mankato, Minnesota.
    Purpose: The purpose of this study was to quantify the effects of several moisturizers on hydration of the stratum corneum by measuring their effect on electrical conductance over a 24-hour period.

    Design: Double-blind, randomized controlled trial.

    Subjects And Setting: Twenty-five healthy female volunteers aged 18 to 65 years with dry skin on the lower legs and no other known dermatologic pathology participated in the study. Read More

    The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study.
    Clin Cosmet Investig Dermatol 2017 11;10:311-315. Epub 2017 Aug 11.
    Dermatologic Institute Dermig Milan, Milan, Italy.
    Introduction: Moisturizing products are commonly used to improve hydration in skin dryness conditions. However, some topical hydrating products could have negative effects on skin barrier function. In addition, hydrating effects of moisturizers are not commonly evaluated up to 24 hours after a single application. Read More

    Emu oil-based lotion effects on neonatal skin barrier during transition from intrauterine to extrauterine life.
    Clin Cosmet Investig Dermatol 2017 10;10:299-303. Epub 2017 Aug 10.
    Division of Perinatal Medicine, Policlinico Abano Terme, Abano Terme.
    Both appropriate hydration and skin surface pH are fundamental in preventing baby skin barrier damage during transition from intrauterine to extrauterine life. However, effects of topical moisturizers on neonatal stratum corneum temperature, pH, hydration, and elasticity have not been scientifically evaluated in vivo. We checked 31 full-term breastfeeding neonates by non-invasive bioengineering method, which is able to evaluate the basal skin barrier (left heel), and assessed at 6±1 hours after birth, and at 1 and 24 hours after emu oil-based topical treatment. Read More

    Acidic oral moisturizers with pH below 6.7 may be harmful to teeth depending on formulation: a short report.
    Clin Cosmet Investig Dent 2017 3;9:81-83. Epub 2017 Aug 3.
    Department of Operative Dentistry, Faculty of Odontology, University of Iceland and Private Practice, Reykjavic, Iceland.
    Xerostomia affects 30% of the population and manifests as a side effect of medications, systemic diseases, or cancer therapy. Oral moisturizers are prescribed to overcome the ailments of dry mouth and its symptoms. It is imperative that these products help to restore hyposalivation and that they do not present any secondary effect that can harm oral health. Read More

    Fragility of epidermis: acne and post-procedure lesional skin.
    J Eur Acad Dermatol Venereol 2017 Sep;31 Suppl 6:3-18
    A-DERMA, Pierre Fabre Dermo-Cosmétique, Lavaur, France.
    'Fragile skin', or skin with lower resistance to aggressors, can be broadly classified into four causal categories: constitutional (age-dependent or associated with specific vulnerable locations on the body, e.g. eyelids), pathological (related to disease), circumstantial (related to environmental or internal factors, e. Read More

    Use of moisturizers among Danish atopic dermatitis patients-which perceived product characteristics associate with long-term adherence?
    J Dermatolog Treat 2018 Mar 18;29(2):116-122. Epub 2017 Aug 18.
    b Department of Dermatology , Zealand University Hospital , Roskilde , Denmark.
    Purpose: To identify factors perceived as most important regarding choice and continued use of moisturizers for adult patients with AD.

    Method And Materials: Online survey among members of the Atopic eczema society Denmark.

    Results: Among 75 participants, the most commonly tried (89. Read More

    High Colonization and Impaired Permeability Barrier in Facial Seborrheic Dermatitis.
    Chin Med J (Engl) 2017 Jul;130(14):1662-1669
    Department of Dermatology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China.
    Background: Seborrheic dermatitis (SD) is a common inflammatory skin condition. The etiology is unclear, although overgrowth of Malassezia on the skin has been suggested to cause SD. This study investigated whether colonization with Staphylococcus plays a role in facial SD, which was not well addressed previously. Read More

    Combination of benzoyl peroxide 5% gel with liquid cleanser and moisturizer SPF 30 in acne treatment results in high levels of subject satisfaction, good adherence and favorable tolerability.
    J Dermatolog Treat 2018 Feb 5;29(1):49-54. Epub 2017 Jul 5.
    b Galderma R&D , Sophia Antipolis , France.
    Background: Skin care products (cleansers and moisturizers) to complement benzoyl peroxide (BPO) in the treatment of acne may improve treatment tolerability and adherence.

    Objective: Evaluate subject satisfaction after use of BPO 5% gel in combination with liquid cleanser and moisturizer SPF 30.

    Methods: Open-label study including subjects aged ≥12 years with mild-to-moderate facial acne; ClinicalTrials. Read More

    Evaluation of a novel very high sun-protection-factor moisturizer in adults with rosacea-prone sensitive skin.
    Clin Cosmet Investig Dermatol 2017 10;10:211-219. Epub 2017 Jun 10.
    Galderma Research and Development, Egerkingen, Switzerland.
    Background/objective: Rosacea-prone sensitive skin requires high sun-protection factor (SPF) moisturizers. This study evaluated Daylong Extreme SPF 50+ lotion, a novel cream containing five ultraviolet filters, two emollients, and three skin conditioners.

    Subjects And Methods: This was an open-label, single-center study. Read More

    Performance and Tolerability of the Moisturizers Cetaphil and Excipial in Atopic Dermatitis: What is the Evidence Based on Randomized Trials?
    Dermatol Ther (Heidelb) 2017 Sep 9;7(3):331-347. Epub 2017 Jun 9.
    Dutch Association for People with Atopic Dermatitis (VMCE: Vereniging voor Mensen met Constitutioneel Eczeem), Nijkerk, The Netherlands.
    Introduction: Moisturizers play a prominent role in the management of atopic dermatitis by improving the impaired skin barrier function and enhancing skin hydration. Their efficacy was evaluated in a recently published Cochrane Review 'Emollients and moisturizers for eczema'.

    Objective: In the present review, we summarize the performance and safety of Cetaphil and Excipial moisturizing products. Read More

    Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march.
    J Allergy Clin Immunol 2017 Jun;139(6):1723-1734
    Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Laboratory for Investigative Dermatology, Rockefeller University, New York, NY. Electronic address:
    Skin barrier abnormalities have been suggested to play an essential role in initiation of early atopic dermatitis (AD). Antigen penetration through a compromised barrier likely leads to increased innate immune responses, antigen-presenting cell stimulation, and priming of overt cutaneous disease. In a T2-promoting environment, T-cell/B-cell interactions occurring in regional lymph nodes lead to excessive IgE switch. Read More

    Sexual health needs and educational intervention preferences for women with cancer.
    Breast Cancer Res Treat 2017 Aug 25;165(1):77-84. Epub 2017 May 25.
    Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    Purpose: To assess sexual/vaginal health issues and educational intervention preferences in women with a history of breast or gynecologic cancer.

    Methods: Patients/survivors completed a cross-sectional survey at their outpatient visits. Main outcome measures were sexual dysfunction prevalence, type of sexual/vaginal issues, awareness of treatments, and preferred intervention modalities. Read More

    Emollients and moisturizers for eczema: abridged Cochrane systematic review including GRADE assessments.
    Br J Dermatol 2017 Nov 1;177(5):1256-1271. Epub 2017 Oct 1.
    Dutch Association for People with Atopic Dermatitis (VMCE: Vereniging voor Mensen met Constitutioneel Eczeem), Nijkerk, the Netherlands.
    Eczema is a chronic inflammatory skin disorder with considerable impact on quality of life. Emollients or moisturizers are widely recommended, but are these effective and safe? We searched for randomized controlled trials (RCTs) in the Cochrane Skin Group Specialised Skin Register, CENTRAL in The Cochrane Library, MEDLINE, Embase, LILACS, the GREAT database and five trial registers to December 2015. We included 77 RCTs with 6603 participants. Read More

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