Search Our Scientific Publications & Authors

J Cosmet Dermatol 2021 Jun 21. Epub 2021 Jun 21.

Division of Dermatology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Skin care for maintaining skin integrity includes cleansing, skin product use and photoprotection. Inappropriate skin care can lead to skin problems.

Aims: To evaluate the knowledge, attitude and practices in skin care among Thai adolescents. Read More

J Dermatol Sci 2021 Jun 2. Epub 2021 Jun 2.

Strategic Research Planning & Management Office, Drug Discovery Research Dept., Kyoto R&D Center, Maruho Co., Ltd., 93 Chudoji Awata-cho, Shimogyo-ku, Kyoto, 600-8815, Japan.

Background: Mucopolysaccharide polysulfate (MPS) is a heparinoid and MPS-containing formulations are widely used as moisturizers for dry skin and to treat peripheral vascular insufficiency. Although MPS has therapeutic effects in skin diseases with microvascular abnormalities, the effects of MPS on microvascular function remain incompletely understood.

Objective: The aim of this study was to evaluate the functional activities of MPS on human pericytes (HPC) and human dermal microvascular endothelial cells (HDMEC) in vitro, and on microvascular permeability of the skin. Read More

J Allergy Clin Immunol 2021 Jun 15. Epub 2021 Jun 15.

Department of Pediatric Pneumonology and Allergy, Medical University of Warsaw, Warsaw, Poland. Electronic address:

J Allergy Clin Immunol 2021 Jun 15. Epub 2021 Jun 15.

Department of Dermatology and Venerology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Health Sci Rep 2021 Jun 6;4(2):e308. Epub 2021 Jun 6.

Center for Research & Training in Skin Diseases & Leprosy Tehran University of Medical Sciences Tehran Iran.

Introduction: Recently, there are a few moisturizers showing hydrating effects up to 24 hours after single application. Aquaporin 3 might be associated with the degree of skin hydration. We aimed to assess the effects of two brands of 24-hour moisturizers on the skin barrier function, as well as the AQP3 gene expression. Read More

J Am Podiatr Med Assoc 2021 Jun 11. Epub 2021 Jun 11.

Background: The efficacy of antifungals for onychomycosis has been determined in randomized controlled trials (RCTs); interestingly their control arms have demonstrated some therapeutic effects. These controls constitute either placebos (inert pills) or vehicles (all but the antifungal component of the creams). The objective of this research was to determine (i) whether RCT controls exhibited statistically-relevant efficacy rates (i. Read More

J Endocrinol Invest 2021 Jun 12. Epub 2021 Jun 12.

Andrology, Women's Endocrinology and Gender Incongruence Unit, Department of Experimental, Clinical and Biomedical Sciences "Mario Serio", University of Florence, Viale Gaetano Pieraccini 6, 50139, Florence, Italy.

Purpose: To explore the effects of 6-month systemic testosterone (T) administration on clitoral color Doppler ultrasound (CDU) parameters in women with female sexual dysfunction (FSD).

Methods: 81 women with FSD were retrospectively recruited. Data on CDU parameters at baseline and after 6 months with four different treatments were available and thus further longitudinally analyzed: local non-hormonal moisturizers (NH group), n = 37; transdermal 2% T gel 300 mcg/day (T group), n = 23; local estrogens (E group), n = 12; combined therapy (T + E group), n = 9. Read More

Med Clin North Am 2021 Jul;105(4):611-626

Geisel School of Medicine at Dartmouth, Hanover, NH, USA; Department of Dermatology, Dartmouth-Hitchcock Medical Center, 18 Old Etna Road, Lebanon, NH 03766, USA.

This is a comprehensive and current guide for the diagnosis, differential diagnosis, treatment, and management of eczematous dermatitis, with a focus on atopic dermatitis, irritant and allergic contact dermatitis, hand dermatitis including recurrent vesicular and hyperkeratotic types, asteatotic dermatitis, and nummular or discoid dermatitis. Diagnostic options highlighted are clinical history, physical examination, and patch testing. Therapeutic options highlighted are moisturizers, topical corticosteroids, topical calcineurin inhibitors, crisaborole, phototherapy, and systemic medications including biologics. Read More

Biochem Biophys Res Commun 2021 Jul 26;562:100-104. Epub 2021 May 26.

Department of Analytical Biochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan. Electronic address:

Our previous studies have shown that glycerin, which is present at high concentrations in moisturizers and skin lotions, gradually oxidizes to produce methylglyoxal (MGO). In this study, we observed that MGO-treated porcine dermis type-I collagen was carbonylated in an MGO concentration- and time-dependent manner. Furthermore, we examined the structure of advanced glycation end products (AGEs) induced by MGO reacting with type-I collagen. Read More

J Dermatol 2021 May 26. Epub 2021 May 26.

Department of Nephrology, Nippon Medical School, Bunkyo-ku, Japan.

Xerosis and pruritus are common in patients undergoing dialysis. These symptoms are treated with moisturizers, but limited evidence supports the efficacy of such treatment. Our exploratory study suggested the effectiveness of a heparinoid-containing product for xerosis in dialysis patients. Read More

J Cosmet Dermatol 2021 May 12. Epub 2021 May 12.

Medical Dermatology Associates of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: Moisturizers traditionally function to replenish both the intercellular lipid lamella and natural moisturizing factors, and form a hydrolipid film on the skin surface to decrease transepidermal water loss and improve hydration. As we continue to identify epidermal lipid imbalance in patients with atopic dermatitis, we turn to the use of bioactive ingredients in moisturizers for improving barrier repair and function.

Methods: This review aims to explore the modern use of moisturizers in targeting various components of the skin barrier, dampening immune response, and restoring microbial balance. Read More

J Oleo Sci 2021 Jun 7;70(6):787-797. Epub 2021 May 7.

Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University.

1,2-Alkanediols are characteristic cosmetic ingredients because these moisturizers exhibit the antibacterial activity against Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis). Read More

J Menopausal Med 2021 Apr;27(1):1-7

Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Postmenopausal atrophic vaginitis, along with vasomotor symptoms and sleep disorders, is one of the most troublesome symptoms of menopause. However, many women do not manage this symptom properly due to insufficient knowledge of the symptoms or sexual embarrassment. With appropriate treatment, many postmenopausal women can experience relief from discomforts, including burning sensation or dryness of the vagina and dyspareunia. Read More

J Cosmet Dermatol 2021 Apr;20 Suppl 1:5-8

Dermatology Clinic, University of Catania, Catania, Italy.

Background: Moisturizers represent the mainstay of treatment of xerosis and related pruritus in elderly patients.

Aim: In this study, we evaluated the efficacy and tolerability of a 10% urea cream in patients with senile xerosis.

Methods: Twenty patients affected by moderate-to-severe xerosis of the upper or lower extremities were enrolled and instructed to apply twice daily for 2 weeks a cream containing 10% urea. Read More

Int J Environ Res Public Health 2021 04 23;18(9). Epub 2021 Apr 23.

CNRS UMR5305, Tissue Biology and Therapeutic Engineering Laboratory, LBTI, 69367 Lyon, France.

Background: The prevalence of allergies increases worldwide. Allergies may increase the risk of skin reactions.

Objective: To evaluate the prevalence of allergies and skin reactions in the adult population, the strength of their relationship, and their impact on the quality of life. Read More

Ann Dermatol 2020 Oct 29;32(5):375-382. Epub 2020 Sep 29.

Department of Dermatology, National Medical Center, Seoul, Korea.

Background: Social standards for skin health have changed and have led to a rise in the general population's interest to achieve flawless skin.

Objective: To survey the Korean public's perception of skin health and dermatologists and skin-health-related behaviors.

Methods: A total of 355 participants of the Skin Health Expo 2018, held by the Dermatological Research Foundation of the Korean Dermatological Association from September 14 to 16, 2018, completed a questionnaire that assessed demographics, status, and behaviors regarding skin health. Read More

Maturitas 2021 Jun 14;148:55-61. Epub 2021 Apr 14.

Women's Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK.

Introduction: Vulvovaginal atrophy (VVA) is a chronic condition caused by estrogen deficiency. It affects around 50% of postmenopausal women, reducing their general and sexual quality of life as well as the quality of their personal relationships.

Aim: The aim of this clinical guide is to set out an individualized approach to the management of VVA with topical estrogens and non-hormonal preparations. Read More

Asian Pac J Allergy Immunol 2021 Apr 18. Epub 2021 Apr 18.

Skin Center, Srinakharinwirot University, Bangkok, Thailand.

Background: Nowadays, moisturizers contain non-steroidal anti-inflammatory agents that help for treatment of atopic dermatitis (AD). Defensil® (black currant seed oil, sunflower oil, and balloon vine), a new anti-inflammatory, obtained from plant extracts, remain had a few studies for AD.

Objective: To compare the effectiveness of moisturizer containing 3% Defensil®, 5% dexpanthenol and ceramide (LDC) with 5% urea cream in childhood AD treatment. Read More

J Drugs Dermatol 2021 Apr;20(4):s3-s9

Skin is a complex organ comprised of multiple cell types and microstructures that work in concert to serve critical functions and support the body’s homeostasis. It is the outermost, cornified layer of our body that is primarily responsible for the permeability barrier, protecting against external aggressors and preventing water loss from within. The understanding of the organization, functionality, and underlying mechanisms of the skin barrier has evolved greatly through the years. Read More

Int J Legal Med 2021 Jul 30;135(4):1267-1280. Epub 2021 Mar 30.

Institute of Legal Medicine, University Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.

Since the first shedder test was formulated almost 20 years ago, a plethora of different test strategies has emerged. The amount of data generated so far is considerable. However, because of the limited reproducibility of its results, the reliability of the shedder concept is frequently questioned. Read More

Hautarzt 2021 May 24;72(5):384-392. Epub 2021 Mar 24.

Klinik für Hautkrankheiten, Universitätsklinikum Jena, Erfurter Str. 35, 07743, Jena, Deutschland.

Treating the signs of skin ageing or acne scars by chemical peels or ablative lasers is increasingly used worldwide. Due to their reduced invasiveness, these methods are often favored over aesthetic surgical interventions. Both procedures rely on the principle of controlled damage to the skin. Read More

Climacteric 2021 Mar 24:1-12. Epub 2021 Mar 24.

Gynaecologic and Obstetrics Clinic, Department of Women's and Children's Health, University of Padua, Padua, Italy.

Vulvovaginal pathology impairs the quality of life of both women in menopause and those who are not. Different therapies have been proposed, mainly related to estrogen therapy in postmenopausal women. However, some contraindications limit its use, and different moisturizers or lubricants have been tested. Read More

Gynecol Obstet Fertil Senol 2021 May 20;49(5):394-413. Epub 2021 Mar 20.

Service de chirurgie gynécologique et médecine de la reproduction, centre Aliénor d'Aquitaine, CHU de Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France.

Introduction: Genitourinary menopause syndrome (SGUM) is defined as a set of symptoms associated with a decrease of estrogen and other sexual steroids during menopause. The main symptoms are vulvovaginal (dryness, burning, itching), sexual (dyspareunia), and urinary (urinary infections, pollakiuria, nycturia, pain, urinary incontinence by urgenturia). SGUM leads to an alteration of the quality of life, and affects especially women's sexuality. Read More

Am J Clin Oncol 2021 04;44(4):143-149

Departments of Therapeutic Radiology.

Objective: The objective of this study was to examine patterns of care and outcomes of female cancer patients treated for sexual and menopausal symptoms following pelvic radiotherapy (PRT) at our institution's multidisciplinary Sexuality, Intimacy, and Menopause (SIMS) Program.

Materials And Methods: We performed a retrospective review of 69 female patients who received PRT for gynecologic or gastrointestinal malignancies and were referred for SIMS Program intervention. Indications for referral and treatment patterns were summarized. Read More

Dermatol Ther 2021 05 23;34(3):e14934. Epub 2021 Mar 23.

Department of Public Health, Adıyaman University School of Medicine Faculty, Adıyaman, Turkey.

In the present study, the purpose was to evaluate the presence of dermatological symptoms and the effects of mask use on existing dermatological diseases associated with face in patients admitting with any dermatological disease. The present study consisted of 150 patients, including 91 volunteering women and 59 men, admitting to our dermatology clinic with any dermatological symptoms. The presence of symptoms, such as itching, rash, drying and peeling, discomfort, redness, burning, pain, swelling, acne, oily skin symptoms because of mask use, and previous history of facial dermatological disease, whether this disease increased with the use of mask, were questioned. Read More

J Dermatol 2021 May 21;48(5):645-650. Epub 2021 Mar 21.

Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Hand eczema is a major occupational disease, especially in medical workers, reducing their quality of life (QOL) and work productivity. Daily wearing of fabric gloves to prevent loss of moisture and lipids from the surface of the hands has been regarded as good in the management of hand eczema. However, limited evidence is available regarding the efficacy of moisturizing care with daily gloves on hand eczema. Read More

Menopause 2021 03 15;28(6):706-716. Epub 2021 Mar 15.

2nd Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Importance: Genitourinary syndrome of menopause (GSM) consists of genitourinary tract symptoms that occur due to physical changes caused by estrogen concentrations decline after menopause. Unlike menopausal symptoms, which subside with time, GSM symptoms persist throughout a woman's life.

Objective: This article aimed to systematically review the literature to investigate the prevalence of GSM and its treatment. Read More

J Basic Clin Physiol Pharmacol 2021 Mar 16. Epub 2021 Mar 16.

Department of Pharmacy Practice, Indo Soviet Friendship College of Pharmacy, Moga, Punjab, India.

Objectives: Ciprofloxacin (CIPRO) is a fluroquinolone class antibiotic used commonly for the treatment of various acute and chronic bacterial infections. However, recently there is increase in the case reports of CIPRO-induced Cutaneous Adverse Drug Reactions (CADRs). We aim to systematically review all the descriptive studies of CIPRO induced CADRs. Read More

Technol Health Care 2021 ;29(S1):327-334

Institute of Regulatory Science, Beijing Technology and Business University, Beijing 100048, China.

Background: The stratum corneum (SC) is the outermost layer of human skin and deemed as barrier against chemical exposure and water loss. Moisturizers have beneficial effects in treating dry skin, especially the SC. Confocal Raman spectroscopy (CRS) was used to evaluate the efficacy of moisturizers on skin hydration and penetration, with such agents posing inherent characteristics of being noninvasive, nondestructive, timesaving, and cost effective. Read More

Chem Res Toxicol 2021 Apr 7;34(4):1046-1054. Epub 2021 Mar 7.

Sorbonne Université, CNRS, Laboratoire de Biodiversité et Biotechnologies Microbiennes, USR3579, Observatoire Océanologique, 66650 Banyuls-sur-mer, France.

Benzophenone is a mutagen, carcinogen, and endocrine disruptor. Its presence in food products or food packaging is banned in the United States. Under California Proposition 65, there is no safe harbor for benzophenone in any personal care products, including sunscreens, anti-aging creams, and moisturizers. Read More