4,555 results match your criteria Mohs Micrographic Surgery
Br J Dermatol 2018 Dec 11. Epub 2018 Dec 11.
Department of dermatology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Background: Despite the widespread use of Mohs Micrographic Surgery (MMS) for periocular basal and squamous cell carcinoma (together called keratinocyte carcinoma (KC)), follow-up data regarding recurrences are limited.
Objectives: To investigate the recurrence rate for periocular KCs after MMS and describe experience with interdisciplinary collaborations.
Methods: Patients with periocular KCs treated with MMS between 2006 and 2016 in a tertiary MMS referral hospital were included in this retrospective cohort study. Read More
Cureus 2018 Oct 2;10(10):e3401. Epub 2018 Oct 2.
Dermatology, University of Central Florida College of Medicine, Orlando, USA.
Basal cell carcinoma is the most common malignancy worldwide, but it very rarely metastasizes. Perineural invasion in basal cell carcinoma has been well documented in the literature, but evidence of intravascular invasion has rarely been reported. We describe a rare case of metatypical basal cell carcinoma with intravascular invasion and discuss the clinical management associated with this presentation. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013187. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Edgbaston Campus, Birmingham, UK, B15 2TT.
Background: Early accurate detection of all skin cancer types is essential to guide appropriate management, reduce morbidity and improve survival. Basal cell carcinoma (BCC) is usually localised to the skin but has potential to infiltrate and damage surrounding tissue, while cutaneous squamous cell carcinoma (cSCC) and melanoma have a much higher potential to metastasise and ultimately lead to death. Exfoliative cytology is a non-invasive test that uses the Tzanck smear technique to identify disease by examining the structure of cells obtained from scraped samples. Read More
Dermatol Ther 2018 Dec 6:e12799. Epub 2018 Dec 6.
Department of Dermatology, San Jacopo Hospital, V. Ciliegiole 1, 51100 Pistoia, Italy.
Int J Dermatol 2018 Dec 2. Epub 2018 Dec 2.
Department of Dermatology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
The vulva is an unusual site for basal cell carcinoma (BCC). Vulvar BCC accounts for <1% of all BCCs and <5% of all vulvar malignancies. We report the case of an 83 year-old woman who presented with a 2-month history of a tender labial growth, with histopathology confirming nodular BCC. Read More
Quant Imaging Med Surg 2018 Oct;8(9):884-893
Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea.
Background: Simplified hematoxylin and eosin (H&E) staining followed by cryo-sectioning enables rapid identification of cancerous tissue within the procedure room during Mohs micrographic surgery. Yet, a faster evaluation method is desirable as the staining protocol requires physically sectioning of the tissue after freezing, which leads to prolonged sectioning time along with the frozen artifacts that may occur in frozen sectioning.
Methods: We present a multichannel confocal microscopy system to rapidly evaluate cancerous tissue. Read More
Can J Ophthalmol 2018 Dec 27;53(6):600-604. Epub 2018 Mar 27.
Mohs Unit, Sheba Medical Center, Tel Hashomer, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Objective: Postoperative ecchymoses or hematomas can prolong healing from surgery, and a search for locally administered agents that decrease bleeding is warranted. The objective of this study is to evaluate whether preoperative subcutaneous injection of tranexamic acid (TXA) reduces intra- and postoperative bleeding or ecchymoses in skin-only upper eyelid blepharoplasty surgery.
Design: This is a prospective randomized, double-blind, controlled study. Read More
J Am Acad Dermatol 2018 Nov 28. Epub 2018 Nov 28.
Director of Mohs Micrographic and Dermatologic Surgery, Clinical Professor in the Department of Dermatology, University of California San Diego. Electronic address:
Background: Many patients undergoing Mohs micrographic surgery for basal and squamous cell carcinomas are immunocompromised, yet post-operative complications associated with different types of immunosuppression are largely unstudied.
Objective: To determine the incidence and nature of post-operative complications in immunosuppressed patients undergoing Mohs surgery.
Methods: A retrospective cross-sectional chart review of patient characteristics, clinical characteristics, and complications. Read More
Br J Dermatol 2018 Dec 4. Epub 2018 Dec 4.
Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Pathology Unit, Reggio Emilia, Italy.
Background: Frozen histological sections are currently used for intra-operative margin assessment during Mohs surgery. Fluorescence confocal microscopy (FCM) is a new tool, which offers a promising and faster alternative to frozen histology.
Objective: The aim of the present study is to prospectively evaluate in a clinical setting, the accuracy of FCM as compared to frozen sections in BCC's margin assessment. Read More
Hematol Oncol Clin North Am 2019 Feb;33(1):13-24
High-Risk Skin Cancer Clinic, Dana Farber/Brigham and Women's Cancer Center, Mohs and Dermatologic Surgery Center, Brigham and Women's Faulkner Hospital, Harvard Medical School, 1153 Centre Street, Suite 4J, Jamaica Plain, MA 02130-3446, USA. Electronic address:
Basal cell carcinoma (BCC) is the most common malignancy and the incidence is rising. BCCs have low mortality but can cause significant morbidity primarily through local destruction. The pathogenesis is linked to the interplay between environmental and patient-derived characteristics. Read More
Cutis 2018 Oct;102(4):E33-E34
Department of Family Practice, Mercer University School of Medicine, Columbus, Georgia, USA.
Cutis 2018 Oct;102(4):262-264
Silver Falls Dermatology, Salem, Oregon; Department of Dermatopathology, Western University of Health Sciences, Lebanon, Oregon, USA.
Trichodysplasia spinulosa (TS) is a rare skin condition seen in immunosuppressed patients that is characterized by folliculocentric papules with central spiny spicules mainly on the face. We report the case of an 82-year-old woman with a history of treated non-Hodgkin lymphoma and a recent diagnosis of stage IV colon cancer. She presented with clinical and histopathologic findings consistent with TS occurring prior to starting immunosuppressive therapy for colon cancer. Read More
Semin Cutan Med Surg 2018 Dec;37(4):233-235
Mohs Micrographic Surgery and Cutaneous Oncology, Department of Dermatology, University of Colorado, Denver, Colorado, USA.
Semin Cutan Med Surg 2018 Dec;37(4):209
Westchester Dermatology and Mohs Surgery, White Plains Hospital Physician Associates, Mount Kisco and Scarsdale, New York, USA.
J Ultrasound Med 2018 Nov 22. Epub 2018 Nov 22.
Departments of Dermatology, Madrid, Spain.
Objectives: Basal cell carcinoma (BCC) is the most common dermatologic malignant skin cancer. Infiltrative histologic variants are more aggressive and require wider surgical margins or Mohs surgery, in contrast with noninfiltrative variants, which are commonly treated with standard surgical excision. Elastography has not been used to date to differentiate between the histologic variants of BCC. Read More
Dermatol Clin 2019 Jan 1;37(1):83-94. Epub 2018 Nov 1.
Department of Dermatology, The University of Oklahoma Health Sciences Center, 619 Northeast 13th Street, Oklahoma City, OK 73104, USA.
Immunosuppressed patients are at significantly increased risk of developing cutaneous malignancies. These malignancies are often more aggressive compared with the general population and require multidisciplinary care. This article highlights the incidence and risk factors of cutaneous malignancies in this cohort. Read More
J Am Acad Dermatol 2018 Nov 17. Epub 2018 Nov 17.
Department of Dermatology, University of Pennsylvania Health System. Philadelphia, Pennsylvania. Electronic address:
Background: Consensus guidelines recommend microscopic margin control based on high local recurrence risk features and tissue-rearranging reconstruction for keratinocyte carcinomas (KC) but not for cutaneous melanoma.
Objective: To compare high local recurrence risk features and frequency of tissue-rearranging reconstruction for head and neck KC versus melanoma.
Methods: Retrospective cohort study of KC versus melanoma treated at the Hospital of the University of Pennsylvania with Mohs micrographic surgery (MMS). Read More
J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.
Department of Dermatology, University of Pennsylvania Health System. Philadelphia, Pennsylvania. Electronic address:
Specialty site melanomas on the head and neck, hands and feet, genitalia, and pretibial leg have higher rates of surgical complications after conventional excision with postoperative margin assessment (CE-POMA) compared to trunk and proximal extremity (T&PE) melanomas. The "rule of 10s" describes complication rates after CE-POMA of specialty site melanomas: ∼10% risk of upstaging, ∼10% risk of positive excision margins, ∼10% risk of local recurrence, and ∼10-fold increased likelihood of reconstruction with a flap or graft. T&PE melanomas encounter these complications at a lower rate, according to the "rule of 2s. Read More
Ophthalmic Plast Reconstr Surg 2018 Nov 15. Epub 2018 Nov 15.
Servicio de cirugía de Mohs, Instituto de Oncología Angel H. Roffo, and.
Introduction: Vismodegib has shown a significant response rate in locally advanced periocular basal cell carcinoma. Long-term monotherapy is very difficult to accomplish due to primary or secondary resistance and side effects that limit the length of treatment. The use of Vismodegib as neoadjuvant followed by Mohs micrographic surgery is an option. Read More
Int J Surg Case Rep 2018 Nov 1;53:228-230. Epub 2018 Nov 1.
Columbia University Medical Center, Department of Dermatology, New York, NY, 10032, United States. Electronic address:
Introduction: Surgical defects of the popliteal fossa pose a reconstructive challenge to the surgeon, given the intimate relationship of this area with the knee joint and underlying vital neuro-vasculature.
Case Presentation: An 88-year-old woman was treated for a biopsy proven invasive squamous cell carcinoma of the right popliteal fossa with Mohs micrographic surgery. The resultant defect (4. Read More
JAMA Facial Plast Surg 2018 Oct 25. Epub 2018 Oct 25.
Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical School, Michigan Medicine, Ann Arbor.
JAMA Facial Plast Surg 2018 Oct 25. Epub 2018 Oct 25.
Department of Otolaryngology-Head and Neck Surgery, University of Virginia Health System, Charlottesville.
Importance: Reconstructing Mohs defects often requires grafting in the form of full-thickness skin grafts (FTSGs) and composite grafts. These grafts can be complicated by a variable and often indeterminable survival rate. Other researchers have found that delaying FTSG reconstruction improves graft outcomes, but the optimal interval between excision and reconstruction remains unclear, and no study has examined the association between delaying composite graft reconstruction and graft survival. Read More
Facial Plast Surg Clin North Am 2019 Feb;27(1):95-104
Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, 601 North Caroline Street, 6th Floor, Baltimore, MD 21287, USA.
Skin cancer is a common indication for reconstructive surgery of the ear. The unique anatomy of the external ear makes the restoration of form and function challenging for the reconstructive surgeon. This article reviews the relevant anatomy of the ear, defines the goals of reconstruction, outlines the assessment of defects based on location, and describes specific surgical techniques useful in auricular reconstruction. Read More
Facial Plast Surg Clin North Am 2019 Feb;27(1):43-54
Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical School, 1904 Taubman Center, Ann Arbor, MI 48109-5312, USA.
Nasal reconstructive techniques have advanced significantly over the past 50 years. Modern techniques in nasal reconstruction are based on the nasal aesthetic subunits. In order to achieve ideal outcomes, reconstructive surgeons must consider differences in tissue qualities across the nasal aesthetic subunits and formulate reconstructive plans based on these differences. Read More
Facial Plast Surg Clin North Am 2019 Feb;27(1):15-34
Department of Dermatology, University of Colorado Hospital and School of Medicine, Mail Stop F703, 1665 North Aurora Court, Aurora, CO 80045, USA. Electronic address:
Mohs micrographic surgery (MMS) is the gold standard for treating various cutaneous tumors. MMS has evolved into a single-day, outpatient procedure. The tumor is excised, mapped, and processed with frozen, horizontal sections for immediate histologic evaluation. Read More
Facial Plast Surg Clin North Am 2019 Feb;27(1):105-118
Kellogg Eye Center, Michigan Medicine, 1000 Wall Street, Ann Arbor, MI 48105, USA.
Options for periorbital reconstruction include primary wound closure, local flaps, regional/distant flaps, or full-thickness skin grafts. Optimal aesthetic and functional outcomes are achieved by assessing regional contours, skin type, and facial aesthetic units. Like tissue should replace like tissue; for example, skin with skin, tarsus with tarsus (or equivalent material, eg, hard palate, ear cartilage, or autologous substitute), and conjunctiva with mucous membrane or like substitute (buccal mucous membrane, amniotic membrane). Read More
JAAD Case Rep 2018 Nov 3;4(10):996-999. Epub 2018 Nov 3.
Department of Pathology, University of Michigan, Ann Arbor, Michigan.
J Am Acad Dermatol 2018 Oct 29. Epub 2018 Oct 29.
American Academy of Dermatology, Rosemont, Illinois.
The incidence of primary cutaneous melanoma continues to increase each year. Melanoma accounts for the majority of skin cancer-related deaths, but treatment is usually curative following early detection of disease. In this American Academy of Dermatology clinical practice guideline, updated treatment recommendations are provided for patients with primary cutaneous melanoma (American Joint Committee on Cancer stages 0-IIC and pathologic stage III by virtue of a positive sentinel lymph node biopsy). Read More
Actas Dermosifiliogr 2018 Oct 30. Epub 2018 Oct 30.
Unidad de Cirugía Dermatológica de la Cátedra de Dermatología Médico-Quirúrgica, Hospital de Clínicas Dr. Manuel Quintela, Universidad de la República, Montevideo, Uruguay.
Introduction And Objectives: The trapdoor effect is a possible complication in flap reconstructions, particularly those involving the face. It consists of a bulging, elevated deformity that appears 3 weeks after the intervention. To date there has been no consensus on how the trapdoor effect should be treated. Read More
Am J Clin Dermatol 2018 Nov;19(Suppl 1):24-30
Mohs Surgery Unit, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Av San Martin 5481, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
Although significant progress has been made in the understanding of melanoma pathophysiology and therapy, patients with metastatic melanoma still have a poor prognosis. The management of regional nodes remains a matter of debate. By replacing elective lymph node dissection, sentinel lymph node biopsy has revolutionized the treatment of malignant melanoma. Read More
Br J Dermatol 2018 Oct 26. Epub 2018 Oct 26.
Novartis Pharma AG, Basel, Switzerland.
Background: Nail psoriasis is associated with functional impairment, pain and reduced quality of life.
Objective: To demonstrate the superiority of secukinumab vs. placebo in clearing nail psoriasis as assessed by NAil Psoriasis Severity Index (NAPSI) at Week 16 and over time up to Week 132. Read More
Cureus 2018 Aug 21;10(8):e3170. Epub 2018 Aug 21.
Dermatologist, San Diego Family Dermatology, San Diego, USA.
Osteoma cutis is the formation of bone within the skin. It can present as either primary osteoma cutis or secondary osteoma cutis. Secondary osteoma cutis is more common and is associated with inflammatory, infectious, and neoplastic disorders, including basal cell carcinoma. Read More
Australas J Dermatol 2018 Oct 24. Epub 2018 Oct 24.
Oxford Dermatology, Perth, Western Australia, Australia.
Peer-derived Australian Mohs data were used to define volume outliers and a benchmark for quality improvement. Higher volume practice was linked to less complex anatomical locations for surgery. Reflection on individual practice compared to peers may reduce the number of volume outliers in Mohs surgery. Read More
J Am Acad Dermatol 2018 Oct 17. Epub 2018 Oct 17.
Division of Dermatology, Dell Medical School, University of Texas at Austin, Austin, TX.
J Vet Med Sci 2018 Oct 16. Epub 2018 Oct 16.
Gunma Safari Park.
Asian and African elephants are frequently afflicted by foot disorders that can be very challenging to manage even with aggressive therapy. Such conditions may have indirect life-threatening effects. Mohs' paste (zinc chloride based escharotic agent) was used to treat a female Indian elephant (Elephas maximus indicus) aged 39 years with foot disorder at Kanazawa Zoological Gardens. Read More
JAAD Case Rep 2018 Oct 10;4(9):934-937. Epub 2018 Oct 10.
Department of Dermatology, Yale School of Medicine, New Haven, Connecticut.
J Biomed Opt 2018 Oct;24(3):1-6
Gwangju Institute of Science and Technology, School of Mechanical Engineering, Gwangju, Republic of Korea.
Surgical excision (Mohs micrographic surgery) is the standard procedure to treat a melanoma, in which an in situ histologic examination of sectioned skin is carried out repeatedly until no cancer cells are detected. The possibility to identify melanoma from the surrounding skin by femtosecond laser-induced breakdown spectroscopy (fs-LIBS) is investigated. For experiments, melanoma induced on a hairless mouse by injection of B16/F10 murine melanoma cell was sampled in the form of frozen tissue sections as in Mohs surgery and analyzed by fs-LIBS (λ = 1030 nm, τ = 550 fs). Read More
JAAD Case Rep 2018 Oct 3;4(9):887-889. Epub 2018 Oct 3.
Department of Dermatology, Weill Cornell Medical College, New York, New York.
JAAD Case Rep 2018 Oct 3;4(9):869-871. Epub 2018 Oct 3.
Brigham and Women's Hospital, Boston, Massachusetts.
Dermatol Surg 2018 Oct 9. Epub 2018 Oct 9.
Department of Dermatology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Background: The skin hook is a valuable instrument used in the practice of dermatologic surgery. However, because of numerous factors, the degree of its use varies extensively.
Objective: The purpose of this study was to examine practice trends among dermatologic surgeons regarding the use of skin hooks, as well as analyze factors influencing their use. Read More
Dermatol Surg 2018 Nov;44(11):1389-1390
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania.
JAAD Case Rep 2018 Oct 4;4(9):910-914. Epub 2018 Oct 4.
Department of Dermatology and Dermatologic Surgery, Good Samaritan Regional Medical Center/Silver Falls Dermatology, Salem, Oregon.
SAGE Open Med Case Rep 2018 4;6:2050313X18802409. Epub 2018 Oct 4.
Department of Dermatology & Skin Science, Skin Care Centre, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.
A common but under-recognized complication of Mohs micrographic surgery is the development of surgical site telangiectasias after repair. Treatment with pulsed dye laser has shown good results in treating periscar telangiectasias, while treatment with KTP laser has never been studied for this complication. We report the findings in six patients with persistent telangiectasias post-Mohs micrographic surgery and their response to treatment with KTP laser. Read More
Bull Cancer 2018 Nov 5;105(11):1094-1101. Epub 2018 Oct 5.
Centre Oscar Lambret, département de cancérologie générale, 3, rue F. Combemale, 59020 Lille, France.
Dematofibrosarcoma protuberans (DFSP) are very rare (1 to 4 incident cases per million of inhabitants). The local spreading of DFSP is underestimated. The histological diagnosis is challenging but we now know a specific marker (translocation t(17;22)(q22;q13) (COL1A1;PDGFB)). Read More
J Am Acad Dermatol 2018 Oct 5. Epub 2018 Oct 5.
Department of Plastic Surgery and Burn, Taishan People's Hospital, Guangdong Province, China.
Background: Current guidelines recommend local excision margin (EM) with 1 to 2cm on primary merkel cell carcinoma (MCC) site.
Objective: We compared survival outcomes of MCC patients treated with different surgical interventions.
Methods: A retrospective analysis of MCC cases in the SEER database was performed by Kaplan-Meier, competing risk and Cox proportional hazards regression model analyses. Read More
J Am Acad Dermatol 2018 Oct 1. Epub 2018 Oct 1.
Department of Dermatology, University of Rochester Medical Center, Rochester, New York, USA.
J Am Acad Dermatol 2018 Oct 1. Epub 2018 Oct 1.
Division of Dermatologic Surgery, Rochester, Minnesota. Electronic address:
Background: Little information is available to predict which patients require opioid analgesia following cutaneous surgery. When opioids are indicated, information is lacking regarding the optimal opioid agent selection and dosage.
Objective: To make recommendations for opioid prescription after cutaneous surgery. Read More
J Eur Acad Dermatol Venereol 2018 Oct 4. Epub 2018 Oct 4.
Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Background: The lip and surrounding perioral region are susceptible to non-melanoma skin cancer, but the distribution of basal cell and squamous cell carcinoma on the cutaneous and vermilion lips has not been fully elucidated.
Objective: To investigate the distribution of cutaneous and vermilion lip non-melanoma skin cancer and to better describe risk factors, anatomic location, treatment characteristics and oncologic outcomes.
Methods: A retrospective comparative case series of patients undergoing Mohs micrographic surgery (MMS) at a single academic centre for lip and perioral basal cell and squamous cell carcinoma was performed over a 5-year period. Read More
Biol Pharm Bull 2018 Dec 2;41(12):1824-1829. Epub 2018 Oct 2.
Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University.
Mohs paste (MP) is a hospital preparation containing zinc hydrochloride and zinc oxide starch. It is a topical medication used to fixate tissues for the removal of inoperable skin tumors and the management of hemorrhage and exudates, and to prevent foul odor resulting from secondary infections. However, it has problems, such as changes in hardness and viscoelasticity with time and liquefaction by exudate. Read More
Arch Craniofac Surg 2018 Sep 20;19(3):194-199. Epub 2018 Sep 20.
Department of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Busan, Korea.
Background: Cases of simultaneous multiple skin cancers in a single patient have become more common. Due to the multiplicity of lesions, reconstruction in such cases is more difficult than after a single lesion is removed. This study presents a series of patients with multiple facial skin cancers, with an analysis of the surgical removal, reconstruction process, and the results observed during follow-up. Read More