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    1 OF 71

    Nonsurgical Therapies for Basal Cell Carcinoma: A Review.
    Actas Dermosifiliogr 2017 Apr 19. Epub 2017 Apr 19.
    Servicio de Dermatología, Hospital San José, Fundación Universitaria de Ciencias de la Salud, FUCS, Bogotá, Colombia.
    Basal cell carcinoma (BCC) is the most prevalent malignant tumor in humans and the local destruction of tissue that can result from excision has a significant impact on well-being. Treating BCC is costly for health care systems given the high incidence of this tumor, especially in older patients. Standard treatment involves either resection with histologic assessment of margins or Mohs micrographic surgery. Read More

    Subcutaneous dermatofibrosarcoma protuberans, a rare subtype with predilection for the head: A retrospective series of 18 cases.
    J Am Acad Dermatol 2017 Apr 15. Epub 2017 Apr 15.
    Dermatology Department, Instituto Valenciano de Oncologia, Valencia, Spain.
    Background: Dermatofibrosarcoma protuberans (DFSP) typically affects the dermis and subcutaneous tissue. The subcutaneous variant is rare.

    Objective: We sought to characterize the subcutaneous DFSP (SC-DFSP) variant and compare it with cutaneous DFSP (C-DFSP). Read More

    Infection control practices in Mohs micrographic surgery: a U.K. national survey.
    Br J Dermatol 2017 Apr 13. Epub 2017 Apr 13.
    Dermatological Surgery and Laser Unit, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London.
    Mohs micrographic surgery (MMS) is generally considered a safe and effective method of treating certain types of skin cancers, with low reported rates of surgical site infections.(1,2) Practices relating to infection control vary considerably amongst surgeons. Furthermore, emerging evidence suggests clean surgical techniques do not increase infection rates compared to sterile surgical techniques. Read More

    Multistep Approach for Improved Aesthetic and Functional Outcomes for Lower Extremity Wound Closure After Mohs Micrographic Surgery.
    Dermatol Surg 2017 Apr 11. Epub 2017 Apr 11.
    *Department of Plastic Surgery, Rhode Island Hospital and Warren Alpert Medical School, Brown University, Providence, Rhode Island; †Skinpros, LLC, Providence, Rhode Island; ‡Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island.
    Background: Lower extremity wounds present a major clinical challenge.

    Objective: This paper introduces a new multistep approach for improved aesthetic and functional outcome for lower extremity wound closure after Mohs micrographic surgery.

    Patients And Methods: In this prospective case series, 12 consecutive patients undergoing Mohs micrographic surgery for cutaneous malignancies of the lower extremities underwent closure assisted by elastic bandages, proper positioning with 45° flexion of the knee, buried vertical mattress sutures, and careful eversion, using a premium angled stapler. Read More

    Association of Central Nervous System Depression With Topical Brimonidine When Used for Hemostasis: A Serious Adverse Event.
    JAMA Dermatol 2017 Apr 12. Epub 2017 Apr 12.
    Dermatology and Cutaneous Surgery, Florida International University, Miami7Mohs and Procedural Dermatology Fellowship, Skin Institute of South Florida, Coral Springs8Dermatology and Dermatological Surgery, Miller School of Medicine, University of Miami, Miami, Florida9Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, Florida.
    Importance: Minor bleeding is the most common complication of dermatologic surgery. Topical brimonidine, 0.33%, gel has been reported for the use of hemostasis in dermatologic surgery. Read More

    Piloting a new patient-related outcome tool to assess cosmetic outcome in Mohs Micrographic Surgery.
    J Eur Acad Dermatol Venereol 2017 Apr 12. Epub 2017 Apr 12.
    Dermatologic Surgery and Laser Unit, St John's Institute of Dermatology, Guys' and St Thomas' NHS Trust.
    Poor cosmetic outcome is associated with significant negative impact on quality of life (QOL).(1) The degree of psychosocial distress may be more correlated with patient perception rather than objective scar severity. The patient's personal assessment is the primary influence on psychosocial morbidity. Read More

    [Mohs surgery for basal cell carcinoma].
    Ugeskr Laeger 2017 Feb;179(6)
    Micrographic surgery is currently the only technique which ensures complete removal of basal cell carcinomas. The major limitation is the high set-up cost, which is particularly connected with specialized training of surgeons, technicians and the set-up of a histology facility for frozen tissue sectioning and staining. In the long run, however, the cost of Mohs surgery per patient does not exceed that of conventional surgery. Read More

    Burden and treatment patterns of advanced basal cell carcinoma among commercially insured patients in a United States database from 2010 to 2014.
    J Am Acad Dermatol 2017 Apr 6. Epub 2017 Apr 6.
    Novartis Pharmaceuticals Corporation, East Hanover, New Jersey.
    Background: The burden of advanced basal cell carcinoma (aBCC) is not fully understood.

    Objective: To compare BCC disease burden and treatment patterns for aBCC with those for non-aBCC.

    Methods: A retrospective, insurance claims-based study design was used. Read More

    Malignant fibrous histiocytoma masquerading as pyogenic granuloma.
    Orbit 2017 Apr 28;36(2):122-123. Epub 2017 Feb 28.
    d Lions Eye Institute , Perth , Australia.
    A 68-year-old gentleman presented with a lesion that resembled a pyogenic granuloma in his inferior fornix. The lesion was excised and biopsy demonstrated a proliferation of malignant spindle cells. Three weeks following initial excision, the lesion recurred and was removed via wedge excision of the eyelid. Read More

    [Why is it important to differentiate trichoblastic carcinomas (CT) from basal cell carcinomas (CBC). About 21 cases].
    Ann Chir Plast Esthet 2017 Apr 3. Epub 2017 Apr 3.
    Service de chirurgie plastique, reconstructrice et esthétique, hôpitaux universitaire de Strasbourg, 67000 Strasbourg, France.
    Trichoblastic carcinoma is a rare epithelial malignant epithelial tumor, its diagnosis is difficult and the therapeutic management is non-consensual. This retrospective study, carried out between 2009 and 2015, covered 21 cases and analyzed the diagnostic and therapeutic characteristics of trichoblastic carcinomas. Sex ratio is 2. Read More

    Surgical Treatment of Subungual Squamous Cell Carcinoma by Wide Excision of the Nail Unit and Skin Graft Reconstruction: An Evaluation of Treatment Efficiency and Outcomes.
    JAMA Dermatol 2017 Apr 5. Epub 2017 Apr 5.
    Department of Dermatology, Centre Hospitalier Lyon Sud, Pierre-Bénite, France2Health Department, Université Claude Bernard Lyon 1, Lyon, France3Lyons Cancer Research Center, Lyon, France.
    Importance: The best surgical treatment modalities for subungual squamous cell carcinoma (SUSCC) without bone invasion need to be determined. The limited available data on Mohs micrographic surgery do not demonstrate its use as a standard procedure. A previous study in a limited series of patients has shown that wide surgical excision of the nail unit was associated with a low rate of recurrence. Read More

    Tumor recurrence of keratinocyte carcinomas judged appropriate for Mohs micrographic surgery using Appropriate Use Criteria.
    J Am Acad Dermatol 2017 Mar 29. Epub 2017 Mar 29.
    Department of Dermatology (Program for Clinical Research), University of California, San Francisco, California; San Francisco Veterans Affairs Medical Center, San Francisco, California. Electronic address:
    Background: The use of Mohs micrographic surgery (MMS) has increased greatly to treat basal cell and cutaneous squamous cell carcinomas (keratinocyte carcinoma [KC]), and consensus-based Appropriate Use Criteria (AUC) were developed to identify tumors for which MMS is appropriate.

    Objective: We sought to compare recurrence rates after different treatments in tumors judged appropriate for MMS.

    Methods: We used data from an observational prospective cohort study and retrospectively categorized consecutive tumors as appropriate for MMS according to the AUC. Read More

    Histological Mohs Maps Improve the Accuracy of Dermatology Residents' Interpretations of Mohs Slides: A Pilot Study.
    Dermatol Surg 2017 Mar 23. Epub 2017 Mar 23.
    *Department of Dermatology, Lahey Hospital & Medical Center, Burlington, Massachusetts; †Harvard Medical School, Boston, Massachusetts; ‡Brandeis University, Waltham, Massachusetts; §Department of Dermatology, Roger Williams Medical Center, Providence, Rhode Island.
    Background: Effective Mohs surgery depends on accurate histopathological identification and mapping of tumor burden to ensure complete removal of tumor.

    Objective: The purpose of this study is to evaluate whether using a photograph of the histopathological slide as the Mohs map improves mapping accuracy.

    Methods And Materials: Single-blinded pilot study. Read More

    [Malignant cutaneous adnexal neoplasms of the face and scalp: Diagnostic and therapeutic update].
    J Stomatol Oral Maxillofac Surg 2017 Apr 23;118(2):95-102. Epub 2017 Mar 23.
    Service de stomatologie, chirurgie maxillo-faciale et plastique, hôpital Nord, centre hospitalier des Bourrely, 13015 Marseille, France.
    Introduction: Malignant cutaneous adnexal neoplasms are rare and have been characterized only recently. They can occur at any age but preferentially in elderly. There are 3 of them: trichoblastic carcinoma, trichilemmal carcinoma and malignant pilomatricoma. Read More

    Comparative Study of Functional Nasal Reconstruction Using Structural Reinforcement.
    JAMA Facial Plast Surg 2017 Mar 23. Epub 2017 Mar 23.
    Division of Facial Plastic and Reconstructive Surgery, Boston Medical Center, and Department of Otolaryngology-Head and Neck Surgery, Boston University School of Medicine, Boston, Massachusetts.
    Importance: Nasal reconstruction after Mohs surgery is a unique challenge in that it must satisfy both functional and aesthetic goals. Despite some advocacy in the literature for using structural reinforcement to achieve both functional and aesthetic outcomes in soft-tissue reconstruction, no study has validated this claim by comparing reconstruction with and without structural support.

    Objective: To evaluate the effectiveness of and need for structural reinforcement when reconstructing the nasal alar and sidewall subunits. Read More

    Mohs micrographic surgery and secondary intention healing of a plantar melanoma in-situ.
    Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.
    University at Buffalo, Jacobs School of Medicine, Department of Dermatology, Buffalo, New York.
    This report details an acral melanoma in-situ on theright plantar foot that was successfully treated withMohs micrographic surgery and secondary intentionwound healing. Read More

    Cutaneous leishmaniasis mimicking squamous cell carcinoma.
    Dermatol Online J 2017 Jan 15;23(1). Epub 2017 Jan 15.
    Department of Dermatology, Baylor College of Medicine, Houston, Texas.
    A 41-year-old man from Cuero, Texas with a nonhealinglesion on his left cheek was referred to ourclinic for removal of a squamous cell carcinoma. Thepatient first noticed a "pimple" on his left cheek 3-4months prior to presentation. When the lesion beganto grow he presented to his primary care physician anda biopsy was taken, showing "atypical squamous cellproliferation. Read More

    Functionality of Patients 75 Years and Older Undergoing Mohs Micrographic Surgery: A Multicenter Study.
    Dermatol Surg 2017 Mar 21. Epub 2017 Mar 21.
    *Vujevich Dermatology Associates, Pittsburgh, Pennsylvania; †Department of Dermatology, Northwestern University, Chicago, Illinois; ‡Department of Dermatology, St. Louis University, St. Louis, Missouri; §The Dermatology Group, West Orange, New Jersey; ‖Laser and Skin Surgery Center of Indiana, Carmel, Indiana; ¶Surgical Dermatology Group, Birmingham, Alabama; #Dermatology and Skin Surgery Center of Princeton, Princeton, New Jersey; **Dermatologic Surgery Specialists, PC, Macon, Georgia; ††Mercer Medical School, Macon, Georgia; ‡‡Department of Dermatology, University of California, Los Angeles, Los Angeles, California; §§Division of Dermatology, Cooper University Hospital, Marlton, New Jersey.
    Background: Mohs surgery is indisputably a highly effective treatment for nonmelanoma skin cancers. In the current health care environment, physicians are challenged to provide high quality, efficacious care in a manner that is mindful of the patient's general health and well-being. We have used a functional assessment to evaluate older patients who present for Mohs surgery. Read More

    Herpes Zoster at the Site of Mohs Micrographic Surgery in an Immunocompromised Individual.
    Dermatol Surg 2017 Mar 17. Epub 2017 Mar 17.
    University of Central Florida College of Medicine, Orlando, Florida Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts.

    Clinical Features and Treatment of Dermatofibrosarcoma Protuberans Affecting the Vulva: A Literature Review.
    Dermatol Surg 2017 Mar 17. Epub 2017 Mar 17.
    *Department of Medicine, Division of Dermatology, Creighton University School of Medicine, Omaha, Nebraska; †Department of Biology, Loyola Marymount University, Los Angeles, California.
    Background: Dermatofibrosarcoma protuberans (DFSP) is a low-to-intermediate grade cutaneous neoplasm with a low propensity for metastasis and a high rate of local recurrence. It typically presents as a dermal plaque or nodule on the trunk, limbs, or head and neck region. Vulvar DFSP has also been described, although it is less common. Read More

    Online patient-reported reviews of Mohs micrographic surgery: qualitative analysis of positive and negative experiences.
    Cutis 2017 Feb;99(2):E25-E29
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, and the Department of Dermatology, DuPage Medical Group, Naperville, Illinois, USA.
    Mohs micrographic surgery (MMS) is the gold standard for treating high-risk skin cancers and skin cancers in areas where skin sparing is essential. However, relatively little is known about patient-reported satisfaction with this procedure. In this study, we used qualitative research methods to determine themes of patient-reported satisfaction and dissatisfaction with MMS on one popular online resource (RealSelf). Read More

    Staged retroauricular flap for helical reconstruction after Mohs micrographic surgery.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):144-147
    Hospital Santa Casa de Curitiba - Curitiba (PR), Brazil.
    Staged retroauricular flap is a great option for full-thickness defects along the helical rim and antihelix. Donor site consists of the posterior ear, postauricular sulcus and mastoid area. The advantages of this flap include hidden donor scar, donor tissue similarity and rich vascularity. Read More

    Paramedian forehead flap combined with hinge flap for nasal tip reconstruction.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):140-143
    Hospital Santa Casa de Curitiba - Curitiba (PR), Brazil.
    The paramedian forehead flap is a great option for restoration of complex nasal defects. For full-thickness defects, it may be used alone or in combination with other methods. We present a patient with a basal cell carcinoma on the distal nose treated by Mohs micrographic surgery, and a resulting full-thickness defect repaired with paramedian forehead flap combined with a hinge flap. Read More

    An Aggressive Microcystic Adnexal Carcinoma Infiltrating the Sternum.
    J Drugs Dermatol 2017 Feb;16(2):180-181
    Microcystic adnexal carcinoma is a rare cutaneous tumor that is often misdiagnosed and has the potential to be aggressive. Mohs surgery is the treatment of choice to prevent recurrences. We present a case of a large recurrent microcystic adnexal carcinoma on the sternum, initially diagnosed as a basal cell carcinoma. Read More

    Primary Cribriform Carcinoma of the Eyelid With Neuroendocrine Features: A Case Report.
    J Drugs Dermatol 2017 Feb;16(2):173-174
    A variety of tumors may involve the eyelid, most of which are primary, but rarely can be metastatic. Previously reported eyelid primary carcinomas with neuroendocrine features include Merkel cell carcinoma, apocrine and eccrine gland carcinoma, sebaceous gland carcinoma, and one report of primary "well-differentiated neuroendocrine tumor." Herein we report the first case of primary cribriform carcinoma of the eyelid with neuroendocrine features. Read More

    Vismodegib Therapy for Basal Cell Carcinoma in an 8-Year-Old Chinese Boy with Xeroderma Pigmentosum.
    Pediatr Dermatol 2017 Mar;34(2):163-165
    Nellis Air Force Base, Mike O'Callaghan Federal Medical Center, Las Vegas, Nevada.
    Vismodegib is an oral inhibitor of the Hedgehog signaling pathway and has been used to treat basal cell carcinoma (BCC) in adults. This article reports clearance of a nodular BCC of the nasal tip in an 8-year-old boy with xeroderma pigmentosum (XP). BCC can pose therapeutic challenges when located in areas that are not amenable to traditional therapies such as Mohs micrographic surgery or topical agents. Read More

    Solitary Large Keratoacanthomas of the Head and Neck: An Observational Study.
    Dermatol Surg 2017 Mar 14. Epub 2017 Mar 14.
    *Department of Medicine, Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York; †Weill Cornell Medicine, New York, New York; ‡Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
    Background: Solitary large keratoacanthomas (KAs) of the head and neck present a management dilemma, as no reliable means to predict the clinical course is available. Although typically considered a low-grade tumor, KAs are reported to invade/metastasize, prompting more aggressive treatment. There is little published regarding factors that predict when a KA behaves more like an aggressive squamous cell carcinoma (SCC). Read More

    Mohs Micrographic Surgery as a Digit-Sparing Treatment for Aggressive Digital Papillary Adenocarcinoma.
    Dermatol Surg 2017 Mar 13. Epub 2017 Mar 13.
    Department of Dermatology, Oregon Health and Science University, OHSU Center for Health and Healing, Portland, Oregon Department of Surgery, Oregon Health and Science University, OHSU Center for Health and Healing, Portland, Oregon.

    Organ Sparing Surgery in Penile Cancer: A Systematic Review.
    J Urol 2017 Mar 9. Epub 2017 Mar 9.
    Department of Urology, University of Arkansas for Medical Sciences (UAMS), Little Rock, Arkansas.
    Purpose: Although penile cancer (PC) only represents 1% of all male cancers, the traditional treatment of total or subtotal penectomy carries devastating psychological and functional outcomes. Organ sparing surgery (OSS) in PC is an attractive option if it can provide satisfactory cancer control equivocal or near equivocal to standard techniques. In fact, these techniques are meeting increasing acceptance. Read More

    Effectiveness of Mohs micrographic surgery for nonmelanoma skin cancer: a systematic review protocol.
    JBI Database System Rev Implement Rep 2017 Mar;15(3):666-675
    1Rutgers School of Social Work, Rutgers University, New Brunswick, New Jersey, USA 2Division of Nursing Science, School of Nursing, Rutgers University, Newark, New Jersey, USA 3The Northeast Institute for Evidence Synthesis and Translation (NEST): a Joanna Briggs Institute Center of Excellence, Rutgers University, Newark, New Jersey, USA 4Department of Epidemiology, School of Public Health, Rutgers University, New Brunswick, New Jersey, USA 5School of Public Health, Faculty of the Health and Medical Sciences, The University of Adelaide, Adelaide, Australia 6Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, USA 7Division of Entry to Baccalaureate Practice, School of Nursing, Rutgers University, Newark, New Jersey, USA 8VA New Jersey Health Care System, East Orange, New Jersey, USA 9Department of Dermatology, Rutgers New Jersey Medical School, Newark, New Jersey, USA 10John Cotton Dana Library, Rutgers University, Newark, New Jersey, USA 11Denver Veteran Affairs Medical Center, Denver, Colorado, USA 12Department of Dermatology, School of Medicine, University of Colorado, Denver, Colorado, USA.
    Review Objectives/questions: The objective of the review is to evaluate the effectiveness of Mohs micrographic surgery on the mortality, recurrence and quality of life of patients with nonmelanoma skin cancers when compared with other treatment modalities.Specifically, it aims to examine the effectiveness of Mohs micrographic surgery compared with other treatment modalities such as excisional surgery, curettage and electrodessication and radiation therapy, as well as nonsurgical/chemotherapeutic interventions such as topical 5-fluorouracil and imiquimod immunotherapy in the management of nonmelanoma skin cancers. Read More

    Ocular Adnexal Reconstruction for Cutaneous Periocular Malignancies.
    Semin Plast Surg 2017 Feb;31(1):22-30
    Oculoplastic and Orbital Surgery, Morgenstern Center for Orbital and Facial Plastic Surgery, Wayne, Pennsylvania.
    Although the majority of lesions present in the periocular region are benign, periocular cutaneous malignancies are certainly not uncommon and must be considered. The management of nonmelanoma cutaneous malignancies is predominately surgical with Mohs micrographic surgery or excision with frozen sections. The approach to reconstruction of the resulting defects depends on the defect location and size. Read More

    Outcomes of Melanoma In Situ Treated With Mohs Micrographic Surgery Compared With Wide Local Excision.
    JAMA Dermatol 2017 Feb 22. Epub 2017 Feb 22.
    Department of Dermatology, University of California, San Francisco2Dermatology Service, Veterans Affairs Medical Center, San Francisco, California.
    Importance: Melanoma in situ (MIS) is increasing in incidence, and expert consensus opinion recommends surgical excision for therapeutic management. Currently, wide local excision (WLE) is the standard of care. However, Mohs micrographic surgery (MMS) is now used to treat a growing subset of individuals with MIS. Read More

    Applying a Visual Assessment Tool to Facial Linear Scars.
    Facial Plast Surg 2017 Feb 22;33(1):97-101. Epub 2017 Feb 22.
    Department of Surgery, Section of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
    Previous scar scales have focused on verbal descriptions. A nonverbal visual assessment tool would provide a simple way for patients and physicians to quantify scar appearance. The authors sought to use a validated visual assessment tool for linear surgical scars to assess linear scars on the face and to determine whether patients and surgeons rate scars similarly. Read More

    Penile squamous cell carcinoma: a review of the literature and case report treated with Mohs micrographic surgery.
    An Bras Dermatol 2017 Jan-Feb;92(1):95-99
    Department of Dermatology - State University of New York - Downstate and Veterans Affairs Medical Center - Brooklyn (NY), United States.
    The majority of penile carcinoma is squamous cell carcinoma. Although uncommon in the United States, it represents a larger proportion of cancers in the underdeveloped world. Invasive squamous cell carcinoma may arise from precursor lesions or de novo , and has been associated with lack of circumcision and HPV infection. Read More

    Mohs Surgical Reconstruction Educational Activity: a resident education tool.
    Adv Med Educ Pract 2017 8;8:143-147. Epub 2017 Feb 8.
    Department of Dermatology.
    Background: Surgical reconstructive planning following Mohs surgery can be a difficult subject for dermatology residents to master. Prior research demonstrates that active learning is preferred and more effective compared to passive learning models and that dermatology residents desire greater complexity and volume in surgical training. We present a novel, active, problem-based learning tool for the education of Mohs reconstruction with the goal of improving residents' ability to plan surgical reconstructions. Read More

    Sebaceous Carcinoma Arising Within a Nevus Sebaceus Excised by Mohs Micrographic Surgery.
    Dermatol Surg 2017 Feb 17. Epub 2017 Feb 17.
    Department of Dermatology, Houston Methodist Hospital, Houston, Texas The Surgery Center at Plano Dermatology, Plano, Texas Department of Dermatology, Kelsey-Seybold Clinic, Houston, Texas Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.

    An Analysis of Laser Therapy for the Treatment of Nonmelanoma Skin Cancer.
    Dermatol Surg 2017 Feb 9. Epub 2017 Feb 9.
    *Department of Dermatology, Stanford University School of Medicine, Palo Alto, California; †Department of Dermatology, University of California, Irvine, Irvine, California.
    Background: Skin cancer remains the most prevalent type of cancer in the United States, and its burden on the health care system remains substantial. Standard treatments such as cryosurgery, electrodessication and curettage, topical and photodynamic therapies, and surgical excision including Mohs micrographic surgery are not without inherent morbidity, including risk of bleeding, infection, and scar.

    Objective: Lasers may be an alternative for treatment of nonmelanoma skin cancer, and this paper reviews this therapeutic option. Read More

    Sebaceous carcinoma in solid organ transplant recipients.
    Int J Dermatol 2017 Feb 8. Epub 2017 Feb 8.
    Mayo Clinic Arizona, Scottsdale, AZ, USA.
    Background: Though a rare tumor, sebaceous carcinoma is relatively well-described in immunocompetent patients, in whom it often occurs in a periorbital distribution where it has an overall poor prognosis with a high metastasis rate. The effect of transplant-related immunosuppression on the development of sebaceous carcinoma and its outcomes has not been characterized.

    Methods: We collected 9 cases from a single institution of patients developing sebaceous carcinoma after solid organ transplantation. Read More

    Processing Adipose-Rich Mohs Samples: A Comparative Study of Effectiveness of Pretreatment With Liquid Nitrogen Versus Flash Freezing Spray.
    Am J Dermatopathol 2017 Jan 26. Epub 2017 Jan 26.
    *Division of Dermatology, Loyola University Medical Center, Maywood, IL; †Stritch School of Medicine, Loyola University Medical Center, Maywood, IL; ‡Department of Pathology, Loyola University Medical Center, Maywood, IL; and §Division of Health Sciences, Loyola University Chicago, Maywood, IL.
    Processing of adipose-rich Mohs micrographic surgery (MMS) specimens poses challenges that may preclude complete margin evaluation. In this setting, the value of additional freezing methods using various cooling agents has not been previously investigated. The aim of this study is to compare the frozen section quality of high-adipose Mohs specimens processed without additional cooling treatments versus those pretreated with 1,1,1,2-tetrafluoroethane (TFE) or liquid nitrogen (LN2). Read More

    Surgical Treatment and Outcomes of Patients With Extramammary Paget Disease: A Cohort Study.
    Dermatol Surg 2017 Feb 6. Epub 2017 Feb 6.
    *Mayo Medical School, Mayo Clinic College of Medicine, Rochester, Minnesota; †Department of Dermatology, Mayo Clinic, Rochester, Minnesota; ‡Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
    Background: Extramammary Paget disease (EMPD) is a rare intraepithelial adenocarcinoma occurring mainly in the anogenital region. Traditional management with wide local excision has shown high recurrence rates, thus Mohs micrographic surgery (MMS) has emerged as a promising treatment option.

    Objective: To compare long-term outcomes after treatment with MMS or excision for primary EMPD. Read More

    Sebaceous Carcinoma Treated With Mohs Micrographic Surgery.
    Dermatol Surg 2017 Feb;43(2):281-286
    *Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York;†Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri.
    Background: Sebaceous carcinoma is a rare and potentially aggressive adnexal neoplasm with historic data indicating high rates of recurrence, metastasis, and cancer-specific mortality.

    Objective: To evaluate the incidence of local recurrence, metastasis, disease-specific mortality, and all-cause mortality and to identify work-up approaches.

    Patients And Methods/materials: Retrospective review of patients with sebaceous carcinoma treated with Mohs micrographic surgery between 2001 and 2013 at one institution. Read More

    Cost-effectiveness of surgical excision versus Mohs micrographic surgery for nonmelanoma skin cancer: A retrospective cohort study.
    J Res Med Sci 2016 18;21:91. Epub 2016 Oct 18.
    Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Nonmelanoma skin cancer rates are increasing worldwide. Mohs micrographic surgery and surgical excision (SE) are the two treatment methods for this type of cancer. The current paper aims at determining and comparing the cost-effectiveness of SE and Mohs micrographic surgery. Read More

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