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    1 OF 69

    An Analysis of Laser Therapy for the Treatment of Nonmelanoma Skin Cancer.
    Dermatol Surg 2017 Feb 9. Epub 2017 Feb 9.
    *Department of Dermatology, Stanford University School of Medicine, Palo Alto, California; †Department of Dermatology, University of California, Irvine, Irvine, California.
    Background: Skin cancer remains the most prevalent type of cancer in the United States, and its burden on the health care system remains substantial. Standard treatments such as cryosurgery, electrodessication and curettage, topical and photodynamic therapies, and surgical excision including Mohs micrographic surgery are not without inherent morbidity, including risk of bleeding, infection, and scar.

    Objective: Lasers may be an alternative for treatment of nonmelanoma skin cancer, and this paper reviews this therapeutic option. Read More

    Sebaceous carcinoma in solid organ transplant recipients.
    Int J Dermatol 2017 Feb 8. Epub 2017 Feb 8.
    Mayo Clinic Arizona, Scottsdale, AZ, USA.
    Background: Though a rare tumor, sebaceous carcinoma is relatively well-described in immunocompetent patients, in whom it often occurs in a periorbital distribution where it has an overall poor prognosis with a high metastasis rate. The effect of transplant-related immunosuppression on the development of sebaceous carcinoma and its outcomes has not been characterized.

    Methods: We collected 9 cases from a single institution of patients developing sebaceous carcinoma after solid organ transplantation. Read More

    Processing Adipose-Rich Mohs Samples: A Comparative Study of Effectiveness of Pretreatment With Liquid Nitrogen Versus Flash Freezing Spray.
    Am J Dermatopathol 2017 Jan 26. Epub 2017 Jan 26.
    *Division of Dermatology, Loyola University Medical Center, Maywood, IL; †Stritch School of Medicine, Loyola University Medical Center, Maywood, IL; ‡Department of Pathology, Loyola University Medical Center, Maywood, IL; and §Division of Health Sciences, Loyola University Chicago, Maywood, IL.
    Processing of adipose-rich Mohs micrographic surgery (MMS) specimens poses challenges that may preclude complete margin evaluation. In this setting, the value of additional freezing methods using various cooling agents has not been previously investigated. The aim of this study is to compare the frozen section quality of high-adipose Mohs specimens processed without additional cooling treatments versus those pretreated with 1,1,1,2-tetrafluoroethane (TFE) or liquid nitrogen (LN2). Read More

    Surgical Treatment and Outcomes of Patients With Extramammary Paget Disease: A Cohort Study.
    Dermatol Surg 2017 Feb 6. Epub 2017 Feb 6.
    *Mayo Medical School, Mayo Clinic College of Medicine, Rochester, Minnesota; †Department of Dermatology, Mayo Clinic, Rochester, Minnesota; ‡Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
    Background: Extramammary Paget disease (EMPD) is a rare intraepithelial adenocarcinoma occurring mainly in the anogenital region. Traditional management with wide local excision has shown high recurrence rates, thus Mohs micrographic surgery (MMS) has emerged as a promising treatment option.

    Objective: To compare long-term outcomes after treatment with MMS or excision for primary EMPD. Read More

    Sebaceous Carcinoma Treated With Mohs Micrographic Surgery.
    Dermatol Surg 2017 Feb;43(2):281-286
    *Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York;†Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri.
    Background: Sebaceous carcinoma is a rare and potentially aggressive adnexal neoplasm with historic data indicating high rates of recurrence, metastasis, and cancer-specific mortality.

    Objective: To evaluate the incidence of local recurrence, metastasis, disease-specific mortality, and all-cause mortality and to identify work-up approaches.

    Patients And Methods/materials: Retrospective review of patients with sebaceous carcinoma treated with Mohs micrographic surgery between 2001 and 2013 at one institution. Read More

    Cost-effectiveness of surgical excision versus Mohs micrographic surgery for nonmelanoma skin cancer: A retrospective cohort study.
    J Res Med Sci 2016 18;21:91. Epub 2016 Oct 18.
    Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Nonmelanoma skin cancer rates are increasing worldwide. Mohs micrographic surgery and surgical excision (SE) are the two treatment methods for this type of cancer. The current paper aims at determining and comparing the cost-effectiveness of SE and Mohs micrographic surgery. Read More

    Clinical and pathologic factors associated with subclinical spread of invasive melanoma.
    J Am Acad Dermatol 2017 Jan 28. Epub 2017 Jan 28.
    Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
    Background: Indications to treat invasive melanoma with Mohs micrographic surgery (MMS) or analogous techniques with exhaustive microscopic margin assessment have not been defined.

    Objective: Identify clinical and histologic factors associated with subclinical spread of invasive melanoma.

    Methods: This retrospective, cross-sectional study evaluated 216 invasive melanomas treated with MMS and melanoma antigen recognized by T cells 1 immunostaining. Read More

    [Vismodegib Therapy for Periocular Basal Cell Carcinoma].
    Klin Monbl Augenheilkd 2017 Jan 30;234(1):64-69. Epub 2017 Jan 30.
    Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Hamburg-Eppendorf.
    Background Basal cell carcinoma (BCC) is the commonest periorbital tumour. Mohs' micrographic surgery and secondary reconstruction is the therapeutic gold standard for periorbital BCC. In cases of inoperability for any reason, therapeutic alternatives are needed. Read More

    [A Case Report of Continuous Bleeding due to Severe Skin Metastases of Breast Cancer Successfully Treated Using Mohs Paste].
    Gan To Kagaku Ryoho 2016 Nov;43(12):1553-1554
    Dept. of Surgery, Ohkubo Hospital.
    We report a case of severe skin metastases of advanced right breast cancer in an 84-year-old woman. The tumor (T4bN3cM0, Stage III C)was resected in June 2011(BT+AX)after blood transfusion for severe anemia. Radiotherapy to the right chest wall and supraclavicular lymph nodes was performed, and adjuvant hormonal therapy was administered. Read More

    Basal Cell Carcinoma Arising in a Breast Augmentation Scar.
    Aesthetic Plast Surg 2017 Jan 27. Epub 2017 Jan 27.
    Department of Dermatology, University of Virginia Health System, PO BOX 800718, Charlottesville, VA, 22908, USA.
    We report a case of a 46-year-old female who presented with a persistent lesion on the inferior right breast. The lesion was located within the scar from a breast augmentation procedure 12 years ago. The lesion had been treated as several conditions with no improvement. Read More

    Two Suturing Techniques for the Prevention and Treatment of Nasal Valve Collapse After Mohs Micrographic Surgery.
    Dermatol Surg 2017 Jan 20. Epub 2017 Jan 20.
    *Department of Dermatology, Naval Medical Center, Charette Health Care Center, Portsmouth, Virginia; †Dayton Skin Surgery Center, Dayton, Ohio.
    Background: Tumor extirpation of nonmelanoma skin cancer (NMSC) adjacent to the alar groove, using Mohs micrographic surgery (MMS), may risk causing internal nasal valve (INV) collapse, resulting in reduced airflow during inspiration. There are many surgical options described in the literature to repair INV collapse as a postoperative corrective procedure, but few exist as an intra-operative preventative procedure.

    Objective: The authors present 2 distinct methods to prevent and treat INV collapse during the repair of a perialar surgical defect caused by MMS. Read More

    Analysis of effectiveness of a surgical treatment algorithm for basal cell carcinoma.
    An Bras Dermatol 2016 Nov-Dec;91(6):726-731
    Universidade Federal Fluminense (UFF) - Niterói (RJ), Brazil.
    Background:: Surgical excision is the treatment of choice for basal cell carcinoma and micrographic surgery considered the gold standard, however not yet used routinely worldwide available, as in Brazil. Considering this, a previously developed treatment guideline, which the majority of tumors were treated by conventional technique (not micrographic) was tested.

    Objective:: To establish the recurrence rate of basal cell carcinomas treated according to this guideline. Read More

    Effectiveness of the "Mohs and Close Technique" in Increasing the Efficiency of a Mohs Micrographic Surgery.
    J Drugs Dermatol 2016 Dec;15(12):1481-1483
    Introduction: Mohs micrographic surgery (MMS) is successful and cost effective, but may be time consuming as patients are required to wait for final wound repair until margins are clear. We propose for selected cases the "Mohs and Close technique" (MCT), in which the defect is immediately repaired after tumor resection rather than waiting until margins are clear.

    Methods: MCT was only performed on tumors that had clearly de ned borders, low risk histology, whose resulting defect after exci- sion required either a primary or partial closure, and whose repair wouldn't change to a different repair option if further stages of exci- sion were necessary. Read More

    Safety and Efficacy Evaluation of Pulsed Dye Laser Treatment, CO2 Ablative Fractional Resurfacing, and Combined Treatment for Surgical Scar Clearance.
    J Drugs Dermatol 2016 Nov;15(11):1315-1319
    Background & Objective: Surgical scars are an unwanted sequela following surgical procedures. Several different treatment modalities and approaches are currently being employed to improve the cosmesis of surgical scars with each having varying degrees of success. The objective of this study was to assess the ef cacy and safety pulsed dye laser treatment, CO2 ablative fractional resurfacing, and a combined treatment with these two modalities for the cosmetic improvement of surgical scarring that occurred following the surgical removal of skin cancer from different anatomic areas. Read More

    Modified Slow Mohs Technique for Treatment of Cellular Neurothekeoma of the Lip in a Pediatric Patient.
    Dermatol Surg 2016 Sep 23. Epub 2016 Sep 23.
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Saint Louis University School of Medicine, Saint Louis, MissouriDivision of Dermatopathology, Department of Dermatology, Saint Louis University School of Medicine, Saint Louis, MissouriDivision of Mohs Surgery and Cutaneous Oncology, Department of Dermatology, Stony Brook University Hospital, East Setauket, New YorkDepartment of Dermatology, Mayo Clinic, Jacksonville, Florida.

    [Characteristics and risk factors for recurrence of cutaneous squamous cell carcinoma with conventional surgery and surgery with delayed intraoperative margin assessment].
    Cir Cir 2017 Jan 10. Epub 2017 Jan 10.
    Servicio de Dermatología, Hospital General Dr. Manuel Gea González, Ciudad de México, México.
    Background: Non-melanoma skin cancer includes basal cell carcinoma and squamous cell carcinoma (SCC). Basal cell carcinoma is the most common and least aggressive but in a low percentage of cases, despite appropriate wide surgical margins, it can be aggressive, producing local invasion, recurrences and distance metastasis. SCC has a more aggressive behaviour invading first the skin, the lymph nodes and less frequently produces distance metastasis OBJECTIVE: To identify the characteristics of recurrent SCC and frequency of new SCC after conventional surgical and primary closure or closure delayed until a histological reporting of tumour-free surgical margins, in order to achieve a better surgical option, in our Mexican population. Read More

    LN2, CD10, and Ezrin Do Not Distinguish Between Atypical Fibroxanthoma and Undifferentiated Pleomorphic Sarcoma or Predict Clinical Outcome.
    Dermatol Surg 2017 Jan 10. Epub 2017 Jan 10.
    *Division of Dermatology, Department of Medicine, Vanderbilt University, Nashville, Tennessee; †Department of Dermatology, University of Oklahoma, Oklahoma City, Oklahoma; ‡Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.
    Background: Atypical fibroxanthoma (AFX) is a rare cutaneous spindled cell neoplasm. For both diagnostic and therapeutic purposes, it is important to distinguish AFX from other poorly differentiated tumors, including undifferentiated pleomorphic sarcoma (UPS).

    Objective: The authors aimed to identify the clinical, histologic, and immunohistochemical expression of LN2, ezrin, and CD10 in AFX and UPS tumors. Read More

    Clinical factors associated with subclinical spread of in situ melanoma.
    J Am Acad Dermatol 2017 Jan 7. Epub 2017 Jan 7.
    Department of Dermatology, Hospital of the University of Pennsylvania.
    Background: Subclinical spread of in situ melanoma occurs at a wide frequency, ranging from 12% to 71%.

    Objective: To identify clinical factors associated with subclinical spread of in situ melanoma.

    Methods: We used a retrospective, cross-sectional study of 674 consecutive in situ melanomas to examine 627 patients treated with Mohs surgery and melanoma antigen recognized by T cells 1 immunostaining. Read More

    BIOPSY 1-2-3 in Dermatologic Surgery: Improving Smartphone use to Avoid Wrong-Site Surgery.
    Technol Innov 2016 Sep;18(2-3):203-206
    Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
    The smartphone has become a ubiquitous tool in modern culture. Given the current high quality of smartphone cameras, they should be considered a valuable tool for the dermatologic surgeon in the pre-operative consultation. The purpose of this technical note is to describe a methodology using smartphone camera technology to improve the process for capturing biopsy site photographs and including those photos in decision making to maximize cutaneous surgical outcomes. Read More

    Squamous Cell Carcinoma In Situ Upstaged to Invasive Squamous Cell Carcinoma: A 5-Year, Single Institution Retrospective Review.
    Dermatol Surg 2016 Dec 29. Epub 2016 Dec 29.
    *Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; †Department of Dermatology, University of California, San Diego, Medical Center, La Jolla, California; ‡Compass Dermatopathology, La Jolla, California; §Department of Dermatology and Mohs Surgery, Southern California Permanente Medical Group, Fontana, California; ‖Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; ¶Department of Dermatology, University of Pittsburgh Medical Center Health System, Pittsburg, Pennsylvania.
    Background: Shave biopsy may not be able to accurately distinguish squamous cell carcinoma in situ (SCCIS) from invasive squamous cell carcinoma (SCC). Information on the incidence of biopsy-proven SCCIS upstaged to SCC after a more complete histologic examination is limited.

    Objective: To determine the incidence and clinical risk factors associated with upstaging the biopsy diagnosis of SCCIS into invasive SCC based on findings during Mohs micrographic surgery (MMS). Read More

    Applications of Burow's Grafts in the Reconstruction of Mohs Micrographic Surgery Defects.
    Dermatol Surg 2016 Dec 29. Epub 2016 Dec 29.
    Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina.
    Background: Surgical defects in anatomically challenging locations, such as near free margins or crossing cosmetic subunits, may present reconstructive challenges to the dermatologic surgeon. For selected defects, Burow's grafts may produce functional and aesthetic results in a single operative session.

    Objective: To describe the applications of the Burow's graft technique for the repair of defects after Mohs micrographic surgery. Read More

    Broader Practice Indications for Mohs Surgical Defect Healing by Secondary Intention: A Survey Study.
    Dermatol Surg 2016 Dec 29. Epub 2016 Dec 29.
    *Ronald O. Perelman Department of Dermatology, NYU Langone Medical Center, New York, New York; †Eisenhower Medical Center, Rancho Mirage, California; ‡Laser and Skin Surgery Center of New York, New York, New York.
    Background: Recent reports have indicated secondary intention (SI) healing utilization for Mohs surgical defects beyond conventionally accepted indications.

    Objective: To characterize potentially more expansive guidelines for when SI healing is indicated or appropriate in dermatologic surgery.

    Methods: A survey study was e-mailed to the American College of Mohs Surgery in 2015. Read More

    Differentiating Intralymphatic Histiocytosis, Intravascular Histiocytosis, and Subtypes of Reactive Angioendotheliomatosis: Review of Clinical and Histologic Features of All Cases Reported to Date.
    Am J Dermatopathol 2017 Jan;39(1):33-39
    *Virginia Tech Carilion Dermatology and Mohs Surgery, Roanoke, VA; and †Cleveland Clinic, Dermatology and Plastic Surgery Institute, Cleveland, OH.
    Reactive angioendotheliomatosis (REA) is a rare benign angioproliferative condition of the skin, which has been noted to occur in patients with a variety of underlying systemic diseases. Histopathologically, this condition is characterized by vascular proliferation, and endothelial cell hyperplasia within the lumina and around dermal vessels, without significant cellular atypia. Since the first case of RAE was reported in 1958, multiple histologic patterns of benign cutaneous vascular proliferations with similar clinical presentations to RAE have been described in the literature and have been proposed as subtypes of the originally described condition. Read More

    Nodular Fasciitis Complicating a Staged Surgical Excision of Dermatofibrosarcoma Protuberans.
    Case Rep Dermatol Med 2016 27;2016:6074182. Epub 2016 Nov 27.
    Department of Dermatology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
    Dermatofibrosarcoma protuberans (DFSP) is an unusual spindle cell tumor with a high rate of local recurrence with traditional excision. Fortunately, Mohs micrographic surgery yields excellent cure rates for this neoplasm due to contiguous tumor spread and meticulous tumor mapping and margin analysis. We present the unique case of a patient treated with a modified Mohs technique with an analysis of the final margin with permanent sections, who developed a spindle cell neoplasm in the margins of her second stage excision consistent with nodular fasciitis. Read More

    Microcystic Adnexal Carcinoma of the Nasal Tip Treated With Surgical Excision and Rotational Forehead Skin Flap.
    J Craniofac Surg 2016 Nov;27(8):e756-e758
    *Department of Otorhinolaryngology†Department of Pathology‡Department of Plastic Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
    Microcystic adnexal carcinoma (MAC) is a rare malignant cutaneous adenocarcinoma that typically occurs in the head and neck, particularly at the central face. There are only slightly more than 300 patients reported worldwide, and most patients occur in Caucasians. A 72-year-old man was referred to our hospital for definitive treatment of known MAC from previous biopsy. Read More

    Mohs micrographic surgery of rare cutaneous tumours.
    J Eur Acad Dermatol Venereol 2016 Dec 15. Epub 2016 Dec 15.
    Department of Dermatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.
    Background: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumours are poorly defined.

    Objective: To investigate the recurrence rate after MMS for rare cutaneous tumours at a university centre.

    Methods & Materials: Retrospective review of all rare cutaneous tumours treated with MMS at a large university centre between January 2008 and December 2012. Read More

    [Mohs micrographic surgery: 27 year experience in the Northeast of Mexico].
    Cir Cir 2016 Dec 9. Epub 2016 Dec 9.
    Servicio de Dermatología, Hospital Universitario Dr. José E. González, Monterrey, Nuevo León, México. Electronic address:
    Introduction: Skin cancer treatment includes surgical and non-surgical techniques. Among surgical techniques, Mohs micrographic surgery permits a complete evaluation of surgical margins with maximal tissue sparing.

    Material And Methods: Retrospective review of dermatology database of skin cancer cases treated with Mohs surgery at University Hospital Dr. Read More

    The Accuracy of Measurements of Nonmelanoma Skin Cancer Sizes Referred to the Mohs Surgery Clinic.
    J Cutan Med Surg 2016 Dec 8. Epub 2016 Dec 8.
    Division of Dermatology, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
    Background: Tumour size is a crucial factor used to plan Mohs procedures. Larger tumours require more time and stages of excision, and they need to be triaged as a higher priority. Therefore, the accuracy in measurement of tumour size is critical. Read More

    Preoperative telephone consultation does not decrease patient anxiety before Mohs micrographic surgery.
    J Am Acad Dermatol 2017 Mar 4;76(3):519-526. Epub 2016 Dec 4.
    Division of Dermatologic Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
    Background: Many factors influence anxiety and satisfaction of patients undergoing Mohs micrographic surgery (MMS).

    Objective: We sought to determine the effect of a preoperative educational telephone call on anxiety and satisfaction for patients undergoing same-day office consultation and MMS.

    Methods: Patients with skin cancer (N = 104) scheduled for same-day office consultation and MMS were randomly assigned to receive or not to receive an educational telephone call during the week before surgery. Read More

    A case report of malignant obesity hypoventilation syndrome: A weighty problem in our ICUs.
    Respir Med Case Rep 2017 11;20:38-41. Epub 2016 Nov 11.
    Section of Pulmonary and Critical Care, MedStar Washington Hospital Center, USA.
    Introduction: The obesity epidemic is reflected by increasing numbers of morbidly obese patients being admitted to intensive care units (ICUs). These are complicated patients whose care involves many diagnostic and treatment challenges. We are presenting a fatal case of super obesity, hypoventilation, and multi-organ failure known as malignant obesity hypoventilation syndrome (MOHS). Read More

    Injectable Diphenhydramine Used as Anaesthetic for Wide Local Excision With Flap Closure.
    J Cutan Med Surg 2016 Dec 5. Epub 2016 Dec 5.
    The Ottawa Hospital Riverside Campus, Ottawa, ON, Canada.
    Background: Lidocaine-allergic patients pose a challenge for cutaneous surgical procedures. We present a case of a successful wide local excision with flap closures on the face using topical tetracaine followed by infiltration with 1% diphenhydramine.

    Case Summary: An 84-year-old woman, with a lidocaine intolerance, presented to the Mohs surgery clinic for wide local excision of a nodular basal cell carcinoma on her right medial cheek. Read More

    Follicular Malignant Melanoma: A Rare Morphologic Variant of Melanoma. Report of a Case and Review of the Literature.
    Am J Dermatopathol 2016 Nov 29. Epub 2016 Nov 29.
    *Department of Dermatology, University of Illinois at Chicago, Chicago, IL;†Advanced Dermatology and Mohs Surgery, Batavia, IL; and‡Consolidated Pathology Consultants, Libertyville, IL.
    Follicular malignant melanoma (FMM) is an exceedingly rare variant of melanoma. Only 8 cases have been reported in the literature thus far. Often bland on physical examination, FMM shows a striking histologic pattern, with atypical melanocytes sometimes consuming the entire follicle and extending into the dermis. Read More

    Decreasing loco-regional recurrence for oral cavity cancer with total Mohs margins technique.
    J Otolaryngol Head Neck Surg 2016 Dec 1;45(1):63. Epub 2016 Dec 1.
    Department of Otolaryngology - Head & Neck Surgery, CHU de Québec-Université Laval Hôpital de l'Enfant-Jésus, 2705, 1401 18e rue, Québec, Québec, GIJ 1Z4, Canada.
    Background: The conventional technique for cancer resection margin analysis studies only 0.1% of the surgical margins. Complete frozen section margins - also known as Mohs margins - allows for analysis of 100% of the surgical margins. Read More

    Dermatofibrosarcoma protuberans: a case report and review of the literature.
    Hippokratia 2016 Jan-Mar;20(1):80-83
    1st Propedeutic Surgical Department, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    Background: Dermatofibrosarcoma protuberans (DFSP) represents less than 0.1% of all tumors, but it is considered the most common skin sarcoma. Wide local excision (=5 cm) has been largely replaced by Mohs micrographic surgery; however, recurrence is not rare. Read More

    Retrospective Study of Punch Scoring Versus Freehand Approach for First Stage Mohs Micrographic Surgery.
    J Clin Aesthet Dermatol 2016 Sep 1;9(9):55-56. Epub 2016 Sep 1.
    Division of Dermatologic Surgery, Department of Dermatology, Mount Sinai School of Medicine, New York, New York.
    Objective: The objective was to observe whether there is a difference in the number of subjects requiring more than one stage of Mohs micrographic surgery for small lesion nonmelanoma skin cancers using the punch scoring method versus freehand approach. Design: Retrospective review. Setting: Outpatient Mohs Clinic. Read More

    Patient Factors and Their Association with Nonmelanoma Skin Cancer Morbidity and the Performance of Self-skin Exams: A Cross-Sectional Study.
    J Clin Aesthet Dermatol 2016 Sep 1;9(9):16-22. Epub 2016 Sep 1.
    Department of Dermatology & Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida.
    Objective: Mohs micrographic surgery is widely utilized for the treatment of nonmelanoma skin cancers with the advantage of tissue sparing and higher cure rate. The preoperative tumor size and post-Mohs micrographic surgery defect size are useful surrogate measures of nonmelanoma skin cancer morbidity. The authors sought to evaluate whether gender, Hispanic ethnicity, socioeconomic status, sun-safe practices and self-skin exams affected tumor size and Mohs micrographic surgery defect size. Read More

    Near Infrared Fluorescent Nanoparticles Derived from Hyaluronic Acid Improve Tumor Contrast for Image-Guided Surgery.
    Theranostics 2016 1;6(13):2314-2328. Epub 2016 Oct 1.
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, United States;; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, United States.
    Tumor tissue that remains undetected at the primary surgical site can cause tumor recurrence, repeat surgery, and treatment strategy alterations that impose a significant patient and healthcare burden. Intraoperative near infrared fluorescence (NIRF) imaging is one potential method to identify remaining tumor by visualization of NIR fluorophores that are preferentially localized to the tumor. This requires development of fluorophores that consistently identify tumor tissue in different patients and tumor types. Read More

    Rapid visualization of nonmelanoma skin cancer.
    J Am Acad Dermatol 2017 Feb 19;76(2):209-216.e9. Epub 2016 Nov 19.
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Case Western Reserve University, Cleveland, Ohio; National Foundation for Cancer Research Center for Molecular Imaging, Case Western Reserve University, Cleveland, Ohio. Electronic address:
    Background: Mohs micrographic surgery examines all margins of the resected sample and has a 99% cure rate. However, many nonmelanoma skin cancers (NMSCs) are not readily amenable to Mohs micrographic surgery. This defines an unmet clinical need to assess the completeness of non-Mohs micrographic surgery resections during surgery to prevent re-excision/recurrence. Read More

    Lymphoepithelioma-Like Carcinoma of the Skin-A Rare Tumor Treated by Slow Mohs Micrographic Surgery.
    Dermatol Surg 2016 Nov 1. Epub 2016 Nov 1.
    Department of Oral and Maxillofacial Surgery, University College London Hospitals NHS Foundation Trust, London, United Kingdom Department of Dermatology, University College London Hospitals NHS Foundation Trust, London, United Kingdom Dermatopathology Laboratory, Guys and St. Thomas' Hospital NHS Foundation Trust, London, United Kingdom Department of Dermatology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.

    Use of Cyanoacrylate Glue Casting for Stabilization of Periocular Skin Grafts and Flaps.
    Ophthal Plast Reconstr Surg 2016 Nov 10. Epub 2016 Nov 10.
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, U.S.A.
    Purpose: To examine a novel technique for periocular skin graft and flap stabilization using cyanoacrylate glue applied to the host bed around the perimeter of the graft or flap to create an immobile cast in the immediate postoperative period to promote successful graft take and stable anatomic position.

    Methods: Retrospective review was performed of a single surgeon's patients who underwent periocular skin graft or flap between August 1, 2011, and February 29, 2016, in which cyanoacrylate glue was applied postoperatively for graft stabilization. Data examined included indication for procedure, location and size of graft, postoperative complications, and length of follow up postoperatively. Read More

    Head and neck melanoma (excluding ocular melanoma): United Kingdom National Multidisciplinary Guidelines.
    J Laryngol Otol 2016 May;130(S2):S133-S141
    Northern Centre for Cancer Care and Newcastle University, Freeman Hospital,Newcastle upon Tyne,UK.
    This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the United Kingdom. This paper provides consensus recommendations on the management of melanomas arising in the skin and mucosa of the head and neck region on the basis of current evidence. Recommendations • At-risk individuals should be warned about the correlation between ultraviolet radiation (UVR) exposure and skin cancer, and should be given advice on UVR protection. Read More

    Non-melanoma skin cancer: United Kingdom National Multidisciplinary Guidelines.
    J Laryngol Otol 2016 May;130(S2):S125-S132
    Department of Otolaryngology-Head and Neck Surgery,Manchester Royal Infirmary,Oxford Road,Manchester,UK.
    This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. This paper provides consensus recommendations on the management of cutaneous basal cell carcinoma and squamous cell carcinoma in the head and neck region on the basis of current evidence. Recommendations • Royal College of Pathologists minimum datasets for NMSC should be adhered to in order to improve patient care and help work-force planning in pathology departments. Read More

    Histopathologic pitfalls of Mohs micrographic surgery and a review of tumor histology.
    Wien Med Wochenschr 2016 Nov 10. Epub 2016 Nov 10.
    Centro Studi per la Ricerca Multidisciplinare e Rigenerativa, Università Degli Studi "G. Marconi", Rome, Italy.
    Mohs micrographic surgery is a specialized subset of staged surgical excisions with each subsequent stage being driven largely by the histologic findings of the previous stage. Therefore, it is imperative that histologic analysis is performed in an accurate manner. Frozen section and tissue flattening is a crucial step in Mohs surgery. Read More

    Indication guidelines for Mohs micrographic surgery in skin tumors.
    An Bras Dermatol 2016 Sep-Oct;91(5):621-627
    Universidade de São Paulo (USP), São Paulo, SP, Brazil.
    Mohs micrographic surgery is a technique used to excise skin tumors based on comprehensive surgical mapping, in which the surgeon removes the tumor, followed by a complete histological evaluation of the tumor's margins. The correlation of the presence of a tumor in histological examinations and its precise location on the surgical map result in a complete removal of the tumor with maximum normal tissue preservation. The present article seeks to provide general practitioners and healthcare specialists with guidelines regarding recommendations for Mohs micrographic surgery to treat skin tumors, based on the most reliable evidence available in medical literature on the subject. Read More

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