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    A patient case highlighting the myriad of cutaneous adverse effects of prolonged use of hydroxyurea.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    Division of Dermatology, University of Kansas Medical Center, Kansas City, Kansas.
    Background: Hydroxyurea is an antimetabolite primarily used to treat myeloproliferative disorders, and chronic treatment is associated with many cutaneous adverse effects ranging in severity from ichthyosis to aggressive nonmelanoma skin cancer.

    Case Presentation: We report a 67-year-oldman with a history of polycythemia vera who was referred for management of progressively worsening dorsal hand lesions. The patient presented withhyperpigmentation, ichthyosis, plantar keratoderma, dermatomyositis-like eruptions, two squamous cell carcinomas, and actinic keratoses. Read More

    An expanded study of long-pulsed 1064 nm Nd:YAG laser treatment of basal cell carcinoma.
    Lasers Surg Med 2018 Feb 13. Epub 2018 Feb 13.
    Dermatology Cosmetic and Laser Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02114.
    Background And Objective: Basal cell carcinoma (BCC) is an indolent form of skin cancer that is rarely life threatening, but can cause significant cosmetic and functional morbidity. Surgical treatments often result in disfiguring scars, while topical therapies frequently result in recurrence. The need for a more effective nonsurgical alternative has led to the investigation of laser treatment of BCC. Read More

    Basal Cell Adenoma of the Upper Lip Treated With Mohs Micrographic Surgery.
    Dermatol Surg 2018 Feb 6. Epub 2018 Feb 6.
    Division of Dermatology, University of Washington, Seattle, Washington Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri Division of Dermatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.

    Penile-sparing modalities in the management of low-stage penile cancer.
    Urol Ann 2018 Jan-Mar;10(1):1-6
    Department of Urology, Glickman Urologic and Kidney Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
    Penile-sparing modalities are gaining widespread adoption for the management of low-stage penile cancer due to an increasing demonstration of sound oncologic, cosmetic, sexual, psychosocial, and quality of life outcomes. This review aims to provide a comprehensive overview of the respective treatment options in the armamentarium of the practicing urologist in dealing with this rare but problematic condition. Read More

    Demographics and Outcomes of Stage I-II Merkel Cell Carcinoma Treated with Mohs Micrographic Surgery Compared with Wide Local Excision in the National Cancer Data Base.
    J Am Acad Dermatol 2018 Feb 3. Epub 2018 Feb 3.
    Department of Dermatology, Boston University Medical Center, Boston, Massachusetts. Electronic address:
    Background: The optimal surgical approach (wide local excision (WLE) vs. Mohs micrographic surgery (MOHS)) for treating Merkel cell carcinoma (MCC) is yet to be determined.

    Objective: To compare survival outcomes in patients with early stage MCC treated with MOHS versus WLE. Read More

    Emerging trends in the treatment of advanced basal cell carcinoma.
    Cancer Treat Rev 2017 Dec 14;64:1-10. Epub 2017 Dec 14.
    Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
    Basal cell carcinoma (BCC) is the most commonly diagnosed skin cancer worldwide. In most patients, BCC can be effectively treated with standard surgical excision, Mohs micrographic surgery, curettage and electrodessication, radiotherapy, and/or superficial field therapies (including 5-fluorouracil, imiquimod, and photodynamic therapy); however, a minority of patients develop advanced BCC, for which treatment can be challenging and outcomes are poorer. Advanced BCC encompasses a heterogeneous assortment of cases, including metastatic BCC as well as locally advanced BCC (for which no formal definition exists but which generally includes large, deep, aggressive, or recurrent tumors). Read More

    Web App- and Text Message-Based Patient Education in Mohs Micrographic Surgery-A Randomized Controlled Trial.
    Dermatol Surg 2018 Feb 5. Epub 2018 Feb 5.
    Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
    Background: Consent and wound care (WC) videos are used for education in Mohs micrographic surgery (MMS). Postoperative text messaging is poorly studied.

    Objective: Develop and evaluate perioperative resources for MMS patients-video modules (DermPatientEd. Read More

    Laser Corrective Surgery with Fractional Carbon Dioxide Laser Following Full-thickness Skin Grafts.
    J Cutan Aesthet Surg 2017 Jul-Sep;10(3):157-159
    Dermatological Surgery & Laser Unit, St John's Institute of Dermatology, Guy's Hospital Cancer Centre, Guy's & St Thomas' NHS Foundation Trust, London, UK.
    Full-thickness skin grafts (FTSGs) are frequently used to treat patients with burn injuries and to repair defects rendered by excisional (including Mohs) surgery. The evidence for corrective laser surgery after scar formation is well established. With regard to laser treatment of FTSG, the evidence is sparse. Read More

    Use of a novel 1-hour protocol for rapid frozen section immunocytochemistry, in a case of squamous cell carcinoma treated with Mohs micrographic surgery.
    Clin Exp Dermatol 2018 Feb 3. Epub 2018 Feb 3.
    Dermatology Surgery and Laser Unit, St John's Institute, Guys and St Thomas' NHS Trust, London, UK.
    For squamous cell carcinoma (SCC) treated using Mohs micrographic surgery (MMS), interpretation of haematoxylin and eosin-stained frozen sections can be challenging. In these situations, ancillary use of immunostaining is a useful tool for the Mohs surgeon. However, use of immunostaining in MMS laboratories is limited, mainly because current manual immunostaining platforms are subject to operator error, and automated immunostaining, albeit accurate, is too slow for inclusion in MMS. Read More

    Description of patients excluded for Mohs surgery after pre-surgical evaluation: data from the Regesmohs Spanish registry.
    Actas Dermosifiliogr 2018 Jan 17. Epub 2018 Jan 17.
    Clínica Universidad de Navarra, Pamplona, España.
    Background: Regesmohs registry is a nationwide registry including patients evaluated for Mohs surgery in 17 Spanish centres since July 2013. Given that Mohs surgery is the therapy with best results for high risk basal cell carcinoma (BCC) and other skin tumours, we wanted to describe the reasons that lead to some patients being excluded from this therapy and the alternative treatments that they received. These data may be useful to avoid excluding patients for Mohs surgery use, to estimate the healthcare demand of these patients and the demand for Hedgehog inhibitors therapy in this group. Read More

    Nihon Hinyokika Gakkai Zasshi 2017 ;108(1):41-44
    Department of Urology, National Hospital Organization Higashi-Hiroshima Medical Center.
    The patient was a 71-year-old man referred to our department because of asymptomatic gross hematuria. Detailed examination led to a diagnosis of bilateral ureteral cancer and prostate cancer. Total nephroureterectomy was performed for bilateral ureteral cancers on separate occasions, while prostate cancer was managed with hormone therapy. Read More

    Primary treatment of early fistula of parotid duct with botulinum toxin type A injection.
    An Bras Dermatol 2017 Nov-Dec;92(6):864-866
    Private Clinic - São Paulo, SP, Brazil.
    Salivary duct injury can be idiopathic, iatrogenic, or post-trauma and may result in sialocele or fistula. Most injuries regress spontaneously and botulinum toxin A is one of several therapeutic possibilities. We report a case of iatrogenic injury to the parotid duct after Mohs' micographic surgery for a squamous cell carcinoma excision in the left jaw region, treated by injection of botulinum toxin type A. Read More

    New Treatments for Hereditary Angioedema.
    Skin Therapy Lett 2018 01;23(1):6-8
    Virginia Tech Carilion School of Medicine, Roanoke, VA, USA; Carilion Clinic Dermatology & Mohs Surgery, Roanoke, VA, USA.
    Hereditary angioedema is characterized by severe, episodic edema of the subcutaneous and mucosal tissue. The disease carries significant morbidity and mortality due to involvement of the gastrointestinal tract and upper airway. Recent advances in the treatment of hereditary angioedema include new techniques used to isolate and purify human-derived C1 inhibitor, the production of a recombinant form of C1 inhibitor, and the development of drugs that target the kallikrein-kinin pathway. Read More

    Retrospective audit of patients referred for further treatment following Mohs surgery for non-melanoma skin cancer.
    Australas J Dermatol 2018 Jan 18. Epub 2018 Jan 18.
    Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
    Background/objectives: To describe the characteristics, subsequent management and outcomes of patients referred for further management following Mohs micrographic surgery (MMS) for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).

    Methods: Retrospective analysis of patients referred to a quaternary cancer centre from 2000 to 2015.

    Results: In total, 83 lesions in 82 patients were referred for further management; 52 (62%) were SCC and 80 (96%) were located in the head and neck. Read More

    Exploring Laser-Induced Breakdown Spectroscopy as a Potential Tool in Mohs Micrography: A Mini Review.
    Cureus 2017 Nov 13;9(11):e1842. Epub 2017 Nov 13.
    Department of Molecular Oncology, National Institute of Cancer Prevention and Research.
    Mohs micrographic surgery is the technique of surgically removing skin tumors by gradually excising thin layers and visualizing under a microscope till a tumor-free zone is obtained. During the surgical procedure, visible tumors are surgically removed. During the second stage, if tumor margins are clear with the positive specimen at depth, only depth cavitations need to be done without altering the tumor diameter. Read More

    Assessing the Outcomes, Risks, and Costs of Local vs. General Anesthesia: A Review with Implications for Cutaneous Surgery.
    J Am Acad Dermatol 2018 Jan 12. Epub 2018 Jan 12.
    Mohs Micrographic Surgery and Cutaneous Oncology, Dermatology Group of the Carolinas. Concord, Salisbury, Lake Norman, NC. Electronic address:
    Background: There is a paucity of data providing direct comparison of outcomes, complications and costs between general and local anesthesia in cutaneous surgery.

    Objective: Analyze the literature from dermatologic and other specialties to compare outcomes, risks and costs of general and local anesthesia.

    Methods: A retrospective analysis of case comparison studies from other specialties comparing outcomes, risks, and/or costs in local vs. Read More

    Modified second stage Hughes tarsoconjunctival reconstruction for lower eyelid defects.
    Orbit 2018 Jan 15:1-6. Epub 2018 Jan 15.
    a Department of Ophthalmology , University of Virginia , Charlottesville , Virginia , USA.
    To describe a novel technique utilizing an amniotic membrane graft (AMT) to create the mucocutaneous portion of the lower eyelid margin in a modified Hughes eyelid reconstruction for secondary revision or prevention of a hyperemic, hypertrophic conjunctival margin with excessive discharge. This was a retrospective, non-comparative interventional study. Thirty consecutive patients who underwent a modified Hughes reconstruction were included. Read More

    Cutaneousinfection from tattooing: a common yet under-reported and persistent epidemic hazard for dermatologists.
    BMJ Case Rep 2018 Jan 12;2018. Epub 2018 Jan 12.
    Department of Dermatology, University of Florida, Gainesville, Florida, USA.
    Tattoo popularity continues to rise, with 3 in 10 Americans bearing at least one. Among tattoo complications, non-tuberculous mycobacteria (NTM) has emerged as a global public health concern. NTM infections associated with tattooing of immunocompetent individuals have occurred as sporadic cases and community outbreaks. Read More

    Chemical imaging of aggressive basal cell carcinoma using time-of-flight secondary ion mass spectrometry.
    Biointerphases 2018 Jan 12;13(3):03B402. Epub 2018 Jan 12.
    Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg 412 96, Sweden.
    A set of basal cell carcinoma samples, removed by Mohs micrographic surgery and pathologically identified as having an aggressive subtype, have been analyzed using time-of-flight secondary ion mass spectrometry (SIMS). The SIMS analysis employed a gas cluster ion beam (GCIB) to increase the sensitivity of the technique for the detection of intact lipid species. The GCIB also allowed these intact molecular signals to be maintained while surface contamination and delocalized chemicals were removed from the upper tissue surface. Read More

    Indocyanine green loaded hyaluronan-derived nanoparticles for fluorescence-enhanced surgical imaging of pancreatic cancer.
    Nanomedicine 2018 Jan 9;14(3):769-780. Epub 2018 Jan 9.
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE. Electronic address:
    Pancreatic ductal adenocarcinoma is highly lethal and surgical resection is the only potential curative treatment for the disease. In this study, hyaluronic acid derived nanoparticles with physico-chemically entrapped indocyanine green, termed NanoICG, were utilized for intraoperative near infrared fluorescence detection of pancreatic cancer. NanoICG was not cytotoxic to healthy pancreatic epithelial cells and did not induce chemotaxis or phagocytosis, it accumulated significantly within the pancreas in an orthotopic pancreatic ductal adenocarcinoma model, and demonstrated contrast-enhancement for pancreatic lesions relative to non-diseased portions of the pancreas. Read More

    Extramammary Paget Disease of the Vulva: A Case Series Examining Treatment, Recurrence, and Malignant Transformation.
    Int J Gynecol Cancer 2018 Mar;28(3):632-638
    Objectives: Extramammary Paget disease (EMPD) of the vulva is a rare lesion with a high recurrence rate ranging from 12% to 61%. The rate of underlying adenocarcinoma varies, but in the largest series was reported at 4%. Given the rarity of the disease there is a paucity of data to optimize treatment. Read More

    Examining the Relevance to Patients of Complications in the American College of Mohs Surgery Registry: Results of a Delphi Consensus Process.
    Dermatol Surg 2018 Jan 8. Epub 2018 Jan 8.
    Department of Dermatology, St. Louis University, St. Louis, Missouri.
    Background: Surgical registries are valuable tools for tracking outcomes. Incorporating patient input allows registries to address the interests of this important stakeholder group.

    Objective: The aim of this study was to identify a list of "patient-selected complications" and to explore the relevance to patients of previously published physician-identified complications. Read More

    Medical Student Decision-Making: Standard Surgical Excision or Mohs Micrographic Surgery to Manage Basal Cell Carcinoma.
    J Am Osteopath Assoc 2018 Jan;118(1):19-25
    Context: As future physicians, osteopathic medical students will play a critical role in helping patients make informed decisions regarding treatment options.

    Objective: To examine the influence that the time, cost, and cosmetic effects associated with treatment options for basal cell carcinoma (BCC), along with students' demographic characteristics, have on treatment decision-making. The influence that different sources of information have on students was also studied. Read More

    [Complete treatment of basal cell carcinoma; cost effectiveness of Mohs micrographic surgery versus conventional excision].
    Ned Tijdschr Geneeskd 2017 ;161(0):D1549
    Mohs Klinieken, Dordrecht-Amsterdam-Hoorn.
    Objective: To investigate whether Mohs micrographic surgery (MMS) in accordance with the indications in the revised guideline on basal cell carcinoma (BCC) more often leads to complete treatment than conventional excision (CE) and whether the costs are comparable, and to analyse whether this also applies to all primary BCC of the face.

    Design: Retrospective analysis.

    Method: We gathered data on 3374 MMS procedures and calculated per localisation, subtype and size: the percentage of CE that would have been incomplete after applying the recommended surgical margin; the surgical margin necessary to achieve complete excision in > 90% of cases; the final defect after CE and after MMS; the cost of MMS and the cost of CE with postponed reconstruction or, in the case of incomplete CE, subsequent MMS. Read More

    Chemoprevention of Basal and Squamous Cell Carcinoma With a Single Course of Fluorouracil, 5%, Cream: A Randomized Clinical Trial.
    JAMA Dermatol 2018 Feb;154(2):167-174
    Cooperative Studies Program Central Office, Washington, DC.
    Importance: Keratinocyte carcinoma (ie, cutaneous basal and squamous cell carcinoma) is the most common cancer in the United States.

    Objective: To determine whether topical fluorouracil could prevent surgically treated keratinocyte carcinoma.

    Design, Setting, And Participants: The Veterans Affairs Keratinocyte Carcinoma Chemoprevention Trial was a randomized, double-blind, placebo-controlled trial of topical fluorouracil for chemoprevention of keratinocyte carcinoma. Read More

    Automated multimodal spectral histopathology for quantitative diagnosis of residual tumour during basal cell carcinoma surgery.
    Biomed Opt Express 2017 Dec 22;8(12):5749-5766. Epub 2017 Nov 22.
    School of Physics and Astronomy, University Park, University of Nottingham, Nottingham, NG7 2RD, UK.
    Multimodal spectral histopathology (MSH), an optical technique combining tissue auto-fluorescence (AF) imaging and Raman micro-spectroscopy (RMS), was previously proposed for detection of residual basal cell carcinoma (BCC) at the surface of surgically-resected skin tissue. Here we report the development of a fully-automated prototype instrument based on MSH designed to be used in the clinic and operated by a non-specialist spectroscopy user. The algorithms for the AF image processing and Raman spectroscopy classification had been first optimised on a manually-operated laboratory instrument and then validated on the automated prototype using skin samples from independent patients. Read More

    New Combination Strategy of Photodynamic Therapy and Surgery in Treating Recurrent Basal Cell Carcinoma, a Case Report.
    Photodiagnosis Photodyn Ther 2017 Dec 27. Epub 2017 Dec 27.
    Department of Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Harvard Medical School, MA, USA.
    Background: There are several options for BCC treatment. But sometimes, even Mohs surgery isn't desirable because of predicted aggressive surgery. Treatment of recurrent basal cell carcinoma can be a challenge for dermatologists. Read More

    Comorbidity scores associated with limited life expectancy in the very elderly with nonmelanoma skin cancer.
    J Am Acad Dermatol 2017 Dec 26. Epub 2017 Dec 26.
    Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:
    Background: There is controversy regarding nonmelanoma skin cancer (NMSC) treatment in the very elderly, with some suggesting that this population may not live long enough to benefit from invasive treatments. Tools to assess limited life expectancy (LLE) exist, but performance in the very elderly NMSC population has not been well-defined.

    Objective: Define comorbidity scores associated with LLE in the very elderly presenting for management of NMSC. Read More

    Evaluation of mapping biopsies for extramammary Paget's disease: a retrospective study.
    J Am Acad Dermatol 2017 Dec 22. Epub 2017 Dec 22.
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    Background: Extramammary Paget's disease (EMPD) sometimes shows an ill-defined border and an unexpectedly extended tumor spread beyond the clinical borders. Mapping biopsy is one approach for complete surgical removal, but its efficacy has remained controversial.

    Objective: We sought to evaluate the mapping biopsy for EMPD. Read More

    Usefulness of the subunit principle in nasal reconstruction.
    An Bras Dermatol 2017 ;92(5 Suppl 1):159-162
    Department of Dermatology (Mohs surgery) of Hospital Santa Casa de Curitiba - Curitiba (PR), Brazil.
    The subunit principle in nasal reconstruction proposed the concept of reconstructing the specific topographic subunits that were identified as dorsum, tip, columella, the paired alae, sidewalls, and soft triangles. In patients with more than 50% of subunit loss, removing the remaining portion of the subunit and reconstructing the entire subunit may yield better results. The placement of incisions along the borders of the subunits minimizes scar lines. Read More

    Emerging concepts and recent advances in basal cell carcinoma.
    F1000Res 2017 4;6:2085. Epub 2017 Dec 4.
    Department of Dermatology, Section of Cutaneous Oncology and Dermatologic Surgery , Yale University School of Medicine, 40 Temple Street 5A, New Haven, Connecticut, USA.
    Basal cell carcinoma (BCC) is the most common malignancy worldwide, arising from non-keratinizing cells within the basal layer of the epidermis. The incidence of BCC continues to rise annually, increasing the burden of management of these carcinomas and the morbidity associated with their treatment. While surgical interventions such as Mohs micrographic surgery and surgical excision are the standard of care and yield the highest cure rates, the number of non-surgical interventions approved for the treatment of BCC continues to expand. Read More

    Reconstructive methods in Mohs micrographic surgery in Uruguay: A bidirectional descriptive cohort analysis.
    Actas Dermosifiliogr 2017 Dec 14. Epub 2017 Dec 14.
    Cátedra de Dermatología Prof. Dr. Miguel Martínez, Hospital de Clínicas Dr. Manuel Quintela, Universidad de la República, Montevideo, Uruguay.
    Background And Objectives: The primary goal of Mohs micrographic surgery (MMS) is to completely excise a cancerous lesion and a wide range of reconstructive techniques of varying complexity are used to close the resulting wound. In this study, we performed a descriptive analysis of patients who underwent MMS, with a focus on wound closure methods.

    Material And Methods: We conducted a bidirectional descriptive cohort analysis of all MMS procedures performed by a single surgeon between November 2013 and April 2016. Read More

    [What's new in oncodermatology?]
    Ann Dermatol Venereol 2017 Dec;144 Suppl 4:IVS40-IVS46
    AP-HP dermatologie, INSERM U976, université Paris 7-Diderot, hôpital Saint-Louis, Paris, France. Electronic address:
    This 'What's new in oncodermatology?' addresses the developments in 2017 on the epidemiology and management of skin cancers. We observe a constant increase in carcinomas, risk factors for squamous cell carcinoma, especially in transplant recipients where skin cancer mortality is important. Among epidemiological developments in melanoma are increased mortality despite screening, occupational exposure to UV, second melanoma and higher risk after carcinoma. Read More

    [What's new in instrumental dermatology?]
    Ann Dermatol Venereol 2017 Dec;144 Suppl 4:IVS10-IVS15
    Service de dermatologie générale et oncologique, CHU Ambroise-Paré 9, avenue Charles-de-Gaulle, 92200 Boulogne-Billancourt, 75007 Paris, France; cabinet médical, 4 bis, avenue de Ségur, 75007 Paris, France. Electronic address:
    This "What's new in instrumental dermatology" dedicated skin surgeryis based upon a 2015-2017 literature analysis. The excision of skin cancers is an important part of surgical dermatology. Will artificial intelligence and new drug be able to face the increasing need for therapy? Wrong-site surgery is due to multiple factors. Read More

    Mohs micrographic surgery and dermatopathology concordance; An analysis of 1421 Mohs cases over 17 years.
    J Am Acad Dermatol 2017 Dec 13. Epub 2017 Dec 13.
    The Skin Surgery Center, Winston-Salem, NC; Wake Forest Department of Plastic and Reconstructive Surgery, Wake Forest Baptist Health, Winston-Salem, NC. Electronic address:
    Background: The success of Mohs micrographic surgery depends on the surgeon's ability to correctly interpret intraoperative frozen sections.

    Objective: This retrospective study analyzed the rate of concordance between Mohs surgeons and dermatopathologists in reading slides from Mohs surgery cases.

    Methods: A dermatopathologist reviewed all the frozen sections and the corresponding Mohs map for every 30Mohs case at a practice employing 6 different Mohs surgeons from 2001-2017. Read More

    A synchronous incidence of eccrine porocarcinoma of the forearm and facial squamous cell carcinoma: A case report.
    Int J Surg Case Rep 2018 8;42:116-120. Epub 2017 Dec 8.
    Department of Pathology, Sultanah Nur Zahirah Hospital, Jalan Sultan Mahmud, 20400, Kuala Terengganu, Terengganu, Malaysia.
    Introduction: Cutaneous appendageal tumor can differentiate towards or arise from either pilosebaceous apparatus or the eccrine sweat glands. Appendageal tumors are relatively rare, their clinical appearance is non-specific, and the vast majority are not diagnosed until after excision. Eccrine porocarcinoma (EP), also known as malignant eccrine poroma is a rare adnexal tumor arising from the intraepithelial ductal parts of the sweat gland. Read More

    Effectiveness of the Mohs and Close Technique in Increasing the Efficiency of a Mohs Micrographic Surgery.
    J Drugs Dermatol 2017 Dec;16(12):1301-1302
    Editor's note: JDD welcomes Letters to the Editor that discuss controversy surrounding a recently published article. Letters being considered for publication may be sent to the authors of the original article, who may be given the opportunity to reply. Letters will be published at the discretion of the Editors. Read More

    Ex vivo confocal microscopy features of cutaneous squamous cell carcinoma.
    J Biophotonics 2017 Dec 11. Epub 2017 Dec 11.
    Department of Dermatology and Allergy, University Hospital LMU, Munich, Germany.
    Background: Rapid microscopic evaluation of cutaneous squamous cell carcinoma (SCC), its grade of differentiation and level of invasiveness would enable better management of patients' therapy.

    Objectives: Analyzing specific ex vivo confocal microscopy criteria whether they can predict diagnosis of invasive SCC vs carcinoma in situ and poorly differentiated or undifferentiated vs well and moderately differentiated SCC.

    Methods: Ex vivo confocal images of 102 SCCs in 57 patients were evaluated immediately after excision for the presence of predefined criteria based on confocal and histological knowledge. Read More

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