498,062 results match your criteria Modified Radical Neck Dissection


Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs.

Nucleic Acids Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.

Transfer RNA is heavily modified and plays a central role in protein synthesis and cellular functions. Here we demonstrate that ALKBH3 is a 1-methyladenosine (m1A) and 3-methylcytidine (m3C) demethylase of tRNA. ALKBH3 can promote cancer cell proliferation, migration and invasion. Read More

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December 2018

Prognostic value of left atrial strain in predicting cardiovascular morbidity and mortality in the general population.

Eur Heart J Cardiovasc Imaging 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Denmark.

Aims: Left atrial (LA) enlargement predicts cardiovascular risk. The prognostic value of left atrial peak reservoir strain (LA RS) by two-dimensional speckle tracking in the general population is currently unknown. This study sought to determine the prognostic value of LA RS in the general population. Read More

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December 2018

ModL: exploring and restoring regularity when testing for positive selection.

Bioinformatics 2018 Dec 12. Epub 2018 Dec 12.

Department of Mathematics and Statistics, Dalhousie University, Halifax, NS, Canada.

Motivation: Likelihood ratio tests are commonly used to test for positive selection acting on proteins. They are usually applied with thresholds for declaring a protein under positive selection determined from a chi-square or mixture of chi-square distributions. While it is known that such distributions are not strictly justified due to the statistical irregularity of the problem, the hope has been that the resulting tests are conservative and do not lose much power in comparison with the same test using the unknown, correct threshold. Read More

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December 2018

Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1.

Cell Rep 2018 Dec;25(11):3169-3179.e7

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address:

Importins mediate transport from synapse to soma and from cytoplasm to nucleus, suggesting that perturbation of importin-dependent pathways should have significant neuronal consequences. A behavioral screen on five importin α knockout lines revealed that reduced expression of importin α5 (KPNA1) in hippocampal neurons specifically decreases anxiety in mice. Re-expression of importin α5 in ventral hippocampus of knockout animals increased anxiety behaviors to wild-type levels. Read More

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December 2018

An RpaA-Dependent Sigma Factor Cascade Sets the Timing of Circadian Transcriptional Rhythms in Synechococcus elongatus.

Cell Rep 2018 Dec;25(11):2937-2945.e3

Howard Hughes Medical Institute, Harvard University Faculty of Arts and Sciences Center for Systems Biology, Cambridge, MA 02138, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 drives oscillations in global mRNA abundances with 24-hr periodicity under constant light conditions. The circadian clock-regulated transcription factor RpaA controls the timing of circadian gene expression, but the mechanisms underlying this control are not well understood. Here, we show that four RpaA-dependent sigma factors-RpoD2, RpoD6, RpoD5, and SigF2-are sequentially activated downstream of active RpaA and are required for proper expression of circadian mRNAs. Read More

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December 2018

Development and implementation of a pediatric adverse childhood experiences (ACEs) and other determinants of health questionnaire in the pediatric medical home: A pilot study.

PLoS One 2018 12;13(12):e0208088. Epub 2018 Dec 12.

The Center for Youth Wellness, San Francisco, California, United States of America.

Adverse Childhood Experiences (ACEs) are associated with poor health outcomes, underlining the significance of early identification and intervention. Currently, there is no validated tool to screen for ACEs exposure in childhood. To fill this gap, we designed and implemented a pediatric ACEs questionnaire in an urban pediatric Primary Care Clinic. Read More

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December 2018

Chitosan-based nanodelivery systems applied to the development of novel triclabendazole formulations.

PLoS One 2018 12;13(12):e0207625. Epub 2018 Dec 12.

Institute of Plant Biology and Biotechnology (IBBP), Westfälische Wilhelms-Universität Münster, Münster, Germany.

Triclabendazole is a poorly-water soluble (0.24 μg/mL) compound classified into the Class II/IV of the Biopharmaceutical Classification System. It is the drug of choice to treat fascioliasis, a neglected parasitic disease worldwide disseminated. Read More

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December 2018
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First field efficacy trial of the ChAd63 MVA ME-TRAP vectored malaria vaccine candidate in 5-17 months old infants and children.

PLoS One 2018 12;13(12):e0208328. Epub 2018 Dec 12.

Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso.

Background: Heterologous prime boost immunization with chimpanzee adenovirus 63 (ChAd63) and Modified Vaccinia Virus Ankara (MVA) vectored vaccines is a strategy previously shown to provide substantial protective efficacy against P. falciparum infection in United Kingdom adult Phase IIa sporozoite challenge studies (approximately 20-25% sterile protection with similar numbers showing clear delay in time to patency), and greater point efficacy in a trial in Kenyan adults.

Methodology: We conducted the first Phase IIb clinical trial assessing the safety, immunogenicity and efficacy of ChAd63 MVA ME-TRAP in 700 healthy malaria exposed children aged 5-17 months in a highly endemic malaria transmission area of Burkina Faso. Read More

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December 2018

PCSeg: Color model driven probabilistic multiphase level set based tool for plasma cell segmentation in multiple myeloma.

PLoS One 2018 12;13(12):e0207908. Epub 2018 Dec 12.

SBILab, Department of ECE, Indraprastha Institute of Information Technology-Delhi (IIIT-Delhi), New Delhi, India.

Plasma cell segmentation is the first stage of a computer assisted automated diagnostic tool for multiple myeloma (MM). Owing to large variability in biological cell types, a method for one cell type cannot be applied directly on the other cell types. In this paper, we present PCSeg Tool for plasma cell segmentation from microscopic medical images. Read More

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December 2018

Associations between Job-Strain, Physical Activity, Health Status and Sleep Quality Among Swedish Municipality Workers.

J Occup Environ Med 2018 Dec 11. Epub 2018 Dec 11.

Faculty of Health Medicine and Life Sciences, Maastricht University, Netherlands (Leitaru), Department of Health Promotion, School of Nutrition and Translational Research in Metabolism, Maastricht University, Netherlands (Kremers), Institute of Environmental Medicine, Karolinska Institutet, Sweden (Hagberg, Björklund, Kwak).

Objective: To examine the associations between work-stress and physical activity (PA) with sleep quality while controlling for covariates, including social support.

Methods: A cross-sectional study among employees of a municipality (n = 2765). Data from respondents (n = 1973) with good/poor sleep quality were included. Read More

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December 2018

Primary Endovascular Repair of the Ascending Aorta.

Innovations (Phila) 2018 Dec 5. Epub 2018 Dec 5.

From the Cardiac Surgery Department, Parma University Hospital, Parma, Italy.

Different case series have been published demonstrating the feasibility of endovascular repair of the ascending aorta in selected patients deemed unfit for open surgery. However, the use of commercially available stent graft in the ascending aorta remains off-label, and their excessive length often prevents their deployment in the ascending aorta. Here we report a case of successful primary endovascular repair of the ascending aorta using a physician modified off-the-shelf device. Read More

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December 2018

Amino-Functionalized Porous Nanofibrous Membranes for Simultaneous Removal of Oil and Heavy Metal Ions from Wastewater.

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

Both oil spill and heavy metal ions in the industrial wastewater cause severe problems for aquatic ecosystem and human health. In the present work, the electrospun superamphiphilic SiO-TiO porous nanofibrous membranes (STPNMs) comprised of intrafiber mesopores and interfiber macropores are modified by an amino-silanization reaction, which affords the membrane (ASTPNMs) the ability to simultaneously remove the oil contaminants and the water-soluble heavy metal ions from wastewater. The under-water superoleophobicity of ASTPNMs facilitates the highly efficient separation of water and various oils, even emulsifier stabilized emulsion. Read More

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December 2018

Fluorescein sodium ligand-modified silicon nanoparticles produce ultrahigh fluorescence with robust pH- and photo-stability.

Chem Commun (Camb) 2018 Dec 12. Epub 2018 Dec 12.

Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano & Soft Materials (FUNSOM), and Collaborative Innovation Centre of Suzhou Nano Science and Technology (NANO-CIC), Soochow University, Suzhou, Jiangsu 215123, China.

Water-dispersed silicon nanoparticles (SiNPs) are facilely prepared in an aqueous phase via microwave-assisted synthesis. The whole synthetic procedure is accomplished in a one-pot microwave reaction, without the requirement of additional surface modification. Remarkably, the resultant SiNPs feature ultrahigh fluorescence (photoluminescent quantum yield (PLQY): ∼90%), robust pH- and photo-stability, and favourable biocompatibility. Read More

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December 2018

Learning best-practices in journalology: course description and attendee insights into the inaugural EQUATOR Canada Publication School.

BMC Proc 2018 23;12(Suppl 10):18. Epub 2018 Aug 23.

2Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, Canada.

Background And Purpose: Dissemination of research results is a key component of the research continuum and is commonly achieved through publication in peer-reviewed academic journals. However, issues of poor quality reporting in the research literature are well documented. A lack of formal training in journalology (i. Read More

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Removal of Escherichia coli from well water using continuous laminar flow in a channel system containing PPy/Cu modified electrodes.

J Water Health 2018 Dec;16(6):921-929

Instituto de Ingeniería Electroquímica y Corrosión (INIEC), Departamento de Ingeniería Química, Universidad Nacional del Sur - CONICET, Av. Alem 1253, (8000) Bahía Blanca, Argentina E-mail:

Polypyrrole (PPy) films modified with copper species were used for disinfection of well water contaminated with Escherichia coli (E. coli). For that purpose a laboratory-scale continuous flow system with a parallel plate flow chamber configuration was implemented operating under laminar flow. Read More

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December 2018

The Activity of Peptides of the Calcitonin Family in Bone.

Physiol Rev 2019 Jan;99(1):781-805

Department of Medicine, University of Auckland , Auckland , New Zealand.

Calcitonin was discovered over 50 yr ago as a new hormone that rapidly lowers circulating calcium levels. This effect is caused by the inhibition of calcium efflux from bone, as calcitonin is a potent inhibitor of bone resorption. Calcitonin has been in clinical use for conditions of accelerated bone turnover, including Paget's disease and osteoporosis; although in recent years, with the development of drugs that are more potent inhibitors of bone resorption, its use has declined. Read More

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January 2019

Efficacy and safety of pulsed intravenous methylprednisolone in early active thyroid eye disease.

Orbit 2018 Dec 12:1-8. Epub 2018 Dec 12.

a Division of Orbit & Oculofacial Surgery, Department of Ophthalmology , National University Hospital , Singapore , Singapore.

Introduction: The mainstay of therapy for active inflammatory phase of thyroid eye disease (TED) is immunosuppression. Patients in our centre with early active TED are treated with pulsed intravenous methylprednisolone (IVMP). Two different protocols are offered in our centre: High dose (1g/day for 3 days, monthly for 6 months), or EUGOGO protocol (500 mg weekly for six weeks, followed by 250 mg weekly for the next 6 weeks). Read More

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December 2018

Phys-MAPS: a programmatic physiology assessment for introductory and advanced undergraduates.

Adv Physiol Educ 2019 Mar;43(1):15-27

Molecular, Cellular, and Developmental Biology, University of Colorado-Boulder , Boulder, Colorado.

We describe the development of a new, freely available, online, programmatic-level assessment tool, Measuring Achievement and Progress in Science in Physiology, or Phys-MAPS ( http://cperl.lassp.cornell. Read More

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Na+-conductive Na2Ti3O7 modified P2-type Na2/3Ni1/3Mn2/3O2 via a smart in situ coating approach: Suppressing Na+/Vacancy Ordering and P2-O2 Phase Transition.

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

Sodium-ion batteries (SIBs) have shown great superiority for grid-scale storage applications due to the low cost, and the abundance of sodium. P2-type Na2/3Ni1/3Mn2/3O2 cathode materials have attracted much attention for their high capacities and operating voltages as well as their simple synthesis processes. However, Na+/vacancy ordering and the P2-O2 phase transition are unavoidable during Na+ insertion/extraction, leading to undesired voltage plateaus and deficient battery performances. Read More

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December 2018
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Cross-cultural adaptation and validation of Pamela Reed's Self-Transcendence Scale for the Spanish context.

Rev Lat Am Enfermagem 2018 Dec 10;26:e3058. Epub 2018 Dec 10.

Universitat Jaume I, Facultad de Ciencias de la Salud, Castellón, Comunidad Valenciana, Spain.

Objectives: the current study aimed to adapt the Self-Transcendence Scale (STS) to the Spanish context and analyse its psychometric properties.

Method: the STS was administered to a general Spanish population of adults (i.e. Read More

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December 2018

Development and characterization of a novel bulk-fill elastomeric temporary restorative composite.

J Appl Oral Sci 2018 Dec 10;27:e20180183. Epub 2018 Dec 10.

Universidade Federal de Pelotas, Faculdade de Odontologia, Programa de Pós-Graduação em Odontologia (PPGO), Pelotas, Rio Grande do Sul, Brasil.

Objectives: This study investigated the physical and mechanical properties, antibacterial effect and biocompatibility of novel elastomeric temporary resin-based filling materials (TFMs) containing zinc methacrylate (ZM).

Material And Methods: Experimental TFMs were prepared by mixing the zinc methacrylate with monomer, co-monomer, photoinitiator and fillers. A ZM concentration of 0 (control), 0. Read More

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December 2018
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LONG-TERM OUTCOMES OF LIGATION OF INTERSPHINCTERIC FISTULA TRACT FOR COMPLEX FISTULA-IN-ANO: MODIFIED OPERATIVE PROCEDURE EXPERIENCE.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1404. Epub 2018 Dec 6.

Suzhou Affiliated Hospital of Nanjing University of Chinese Medicine, Colorectal Surgery, Su zhou, Jiang su, China.

Background: It is important but difficult to treat complex fistula-in-ano due to the high recurrent rate and following incontinence. Ligation of the intersphincteric fistula tract (LIFT), a novel surgical procedure with the advantage of avoiding anal incontinence, has a variable success rate of 57-94.4 %. Read More

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December 2018
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Influence of tobacco chewing on oral health: A hospital-based cross-sectional study in Odisha.

Indian J Public Health 2018 Oct-Dec;62(4):282-286

Postgraduate Student, Department of Public Health Dentistry, Meenakshi Ammal Dental College, Chennai, Tamil Nadu, India.

Background: Smokeless tobacco use in the Indian subcontinent is a part of many religious and cultural rituals and has gained a degree of social acceptance. The deleterious effects of smokeless tobacco are not as well-known as those produced by smoking.

Objectives: The study was carried out to assess the influence of tobacco chewing on the oral health of adult patients attending the dental outpatients department of Khordha district headquarter, Odisha. Read More

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December 2018

Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis.

Neural Regen Res 2019 Mar;14(3):532-541

Department of Orthopedics, Tianjin Medical University General Hospital; International Science and Technology Cooperation Base of Spinal Cord Injury; Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China.

Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. Read More

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Surgical treatment for severe cubital tunnel syndrome with absent sensory nerve conduction.

Neural Regen Res 2019 Mar;14(3):519-524

Department of Hand Surgery, Huashan Hospital, Fudan University; Key Laboratory of Hand Reconstruction, Ministry of Health; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, China.

For severe cubital tunnel syndrome, patients with absent sensory nerve action potential tend to have more severe nerve damage than those without. Thus, it is speculated that such patients generally have a poor prognosis. How absent sensory nerve action potential affects surgical outcomes remains uncertain owing to a scarcity of reports and conflicting results. Read More

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Exosome-like Nanozyme Vesicles for H2O2-responsive Catalytic Photoacoustic Imaging of Xenograft Nasopharyngeal Carcinoma.

Nano Lett 2018 Dec 12. Epub 2018 Dec 12.

Photoacoustic imaging (PAI) is an attractive imaging modality, which is promising for clinical cancer diagnosis due to its advantages on deep tissue penetration and fine spatial resolution. However, few tumor catalytic/responsive PAI strategies are developed. Here, we design an exosome-like nanozyme vesicle for in vivo H2O2-responsive PAI of nasopharyngeal carcinoma (NPC). Read More

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December 2018

Effect of interfacial water structure on the Hydrogen evolution Reaction on Pt(111) modified with different Nickel Hydroxide coverages in alkaline media.

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

The hydrogen evolution reaction (HER) constitutes one of the most important reactions in electrochemistry due to the value of hydrogen as a vector for energy storage and transport. Therefore, understanding the mechanism of this reaction in relation to its pH-dependence is of crucial importance. While the HER on Pt(111) works efficiently in acid media, in alkaline media the reaction is impeded and considerably larger applied overpotentials are necessary. Read More

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December 2018

Mapping and Quantification of tRNA 2'-O-Methylation by RiboMethSeq.

Methods Mol Biol 2019 ;1870:273-295

Next-Generation Sequencing Core Facility, UMS2008 IBSlor, CNRS-UL-INSERM, BioPole Lorraine University, Nancy, France.

Current development of epitranscriptomics field requires efficient experimental protocols for precise mapping and quantification of various modified nucleotides in RNA. Despite important advances in the field during the last 10 years, this task is still extremely laborious and time-consuming, even when high-throughput analytical approaches are employed. Moreover, only a very limited subset of RNA modifications can be detected and only rarely be quantified by these powerful techniques. Read More

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January 2019

Dot Blot Analysis for Measuring Global N-Methyladenosine Modification of RNA.

Methods Mol Biol 2019 ;1870:263-271

Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.

Posttranscriptional modification of mRNAs plays an important role in establishing the functional diversity of the proteome. The mA modification is found in many species of RNA, including tRNA, mRNA, rRNA, and long noncoding RNAs. The physiological role of mA modification of RNA is not fully explored and is a topic of current research. Read More

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January 2019

Profiling of N-Methyladenosine in Zika Virus RNA and Host Cellular mRNA.

Methods Mol Biol 2019 ;1870:209-218

Department of Pediatrics and Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.

N-Methylation of adenosine (mA) in viral RNA was first identified in Rous sarcoma virus, influenza virus, and SV40 virus several decades ago. More recently, human immunodeficiency virus-1, hepatitis C virus, and Zika virus (ZIKV) RNAs have also been reported to be modified by mA, highlighting the significance of this posttranscriptional RNA modification. Nevertheless, the functions of mA and their roles in the context of viral infections are not completely understood. Read More

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January 2019

Immuno-Northern Blotting: Detection of Modified RNA Using Gel Separation and Antibodies to Modified Nucleosides.

Methods Mol Biol 2019 ;1870:179-187

Department of Medical Science, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan.

Immuno-northern blotting is a method for detecting modified RNAs using gel separation and specific antibodies to modified nucleosides. This method was developed by combining two commonly used molecular biology techniques: western blotting and northern blotting. In this method, urea-polyacrylamide (or agarose) gel-separated RNAs are transferred to positively charged nylon membrane and then immune detection is performed with specific antibodies to modified nucleosides: such as 1-methyladenosine, N6-methyladenosine, and pseudouridine. Read More

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January 2019

HAMR: High-Throughput Annotation of Modified Ribonucleotides.

Methods Mol Biol 2019 ;1870:51-67

Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.

Ribonucleotides can be decorated with over 100 types of covalent chemical modifications. These modifications change the structure, function, and catalytic activity of RNAs, forming a layer of posttranscriptional regulation termed the epitranscriptome. Recent advances in high-throughput mapping have demonstrated these modifications are abundant and mark nearly all classes of RNAs, including messenger RNAs. Read More

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January 2019

Management of Acute Gallstone Cholangitis after Roux-en-Y Gastric Bypass with Laparoscopic Transgastric Endoscopic Retrograde Cholangiopancreatography.

Obes Surg 2018 Dec 11. Epub 2018 Dec 11.

Service de Chirurgie Générale et Endocrinienne, CHU Lille, Hôpital Huriez, Rue Michel Polonowski, 59000, Lille, France.

Background: The incidence of biliary lithiasis is increased after bariatric surgery due to rapid weight loss [1]. Trans-oral endoscopic management in cases of common bile duct gallstone complication is not possible in patients with Roux-en-Y gastric bypass (RYGB) due to the modified anatomy. Access to the biliary tree after RYGB with a classical direct surgical approach of common bile duct and choledocoscopy can be used, but may be complicated in situations of acute cholangitis because of the fragility of common duct, or in cases of previous cholecystectomy. Read More

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December 2018

Nucleic Acid Extraction from Human Biological Samples.

Methods Mol Biol 2019 ;1897:359-383

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Nucleic acid isolation is often the starting point for all downstream experiments in biomedical research. It is therefore the most crucial step in any molecular technique. DNA and RNA extraction follow protocols with standardized reagents, many of which are available in quality-controlled commercial kits. Read More

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January 2019

Effects of various abiotic factors on biomass growth and lipid yield of Chlorella minutissima for sustainable biodiesel production.

Environ Sci Pollut Res Int 2018 Dec 11. Epub 2018 Dec 11.

Bioenergy Research Laboratory, Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee (Saharanpur Campus), Saharanpur, Uttar Pradesh, 247001, India.

In this study, effects of different abiotic factors were studied on biomass and lipid yield of green microalga Chlorella minutissima (C. minutissima) Various concentrations of abiotic factors like nitrogen, phosphorus, glucose, iron, zinc, different values of pH, temperature, light intensity and different photoperiods were observed on the biomass growth and lipid yield of C. minutissima cultivated with modified CHU-13 medium. Read More

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December 2018

Use of Micronized Purified Flavonoid Fraction Together with Rivaroxaban Improves Clinical and Ultrasound Outcomes in Femoropopliteal Venous Thrombosis: Results of a Pilot Clinical Trial.

Adv Ther 2018 Dec 11. Epub 2018 Dec 11.

Pirogov Russian National Research Medical University, Moscow, Russian Federation.

Introduction: The aim of this study was to assess the impact of adding long-term micronized purified flavonoid fraction (MPFF) to standard treatment of femoropopliteal deep vein thrombosis (DVT).

Methods: This pilot, comparative, open-label study with blinded outcome assessor enrolled patients with a first episode of femoropopliteal DVT confirmed by duplex ultrasound scanning (DUS). All participants were randomly allocated to one of two treatment groups: (1) control that received a standard treatment with oral rivaroxaban, and (2) experimental that involved additional treatment with MPFF 1000 mg/day. Read More

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December 2018

Autism Spectrum Disorder and the Experience of Traumatic Events: Review of the Current Literature to Inform Modifications to a Treatment Model for Children with Autism.

J Autism Dev Disord 2018 Dec 11. Epub 2018 Dec 11.

Department of Educational and Counselling Psychology, Faculty of Education, University of British Columbia, 2125 Main Mall, Vancouver, BC, V6T 1Z4, Canada.

Children with autism incur trauma and have increased vulnerabilities for experiencing trauma. This paper summarizes the current literature in the study of trauma in typically developing children and those with autism. A treatment model for children with autism, drawing on components from cognitive behavior therapy (CBT), trauma-focused CBT, and CBT to teach emotion regulation and treat anxiety in children with autism is suggested. Read More

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December 2018

Estrogen receptor gene is associated with dental fluorosis in Brazilian children.

Clin Oral Investig 2018 Dec 11. Epub 2018 Dec 11.

School of Health and Biological Sciences, Universidade Positivo, Rua Professor Pedro Viriato Parigot de Souza, 5300, Campo Comprido, Curitiba, Paraná, 80740-050, Brazil.

Objectives: The aim of this study was investigate the association between genetic polymorphisms in ESR1, ESR2, and ESRRB and dental fluorosis (DF) in a well-characterized sample of children from Curitiba, Brazil.

Material And Methods: From a representative sample of 538 children, 12-year-old were evaluated. DF was assessed in erupted permanent teeth by the Dean's index modified. Read More

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December 2018

Analysis of enhanced nitrogen removal mechanisms in a validation wastewater treatment plant containing anammox bacteria.

Appl Microbiol Biotechnol 2018 Dec 11. Epub 2018 Dec 11.

Department of Civil and Environmental Engineering, National University of Singapore, Block E2-02-13, 1 Engineering Drive 3, Singapore, 117576, Singapore.

Anammox bacteria have attracted attention due to their apparent importance in saving energy and reducing organic chemical demands. Here, we report the detection and quantification of anammox bacteria with an improved primer set in a validation wastewater treatment plant. The improved primer set was shown to detect a broad range of anammox bacteria (47. Read More

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December 2018

Artificial FLOwering plants in Reducing Anxiety and depressive symptoms following Acute Coronary Syndromes (A-FLORA-ACS): a randomised controlled trial.

Heart Vessels 2018 Dec 11. Epub 2018 Dec 11.

MonashHeart, Monash Medical Centre, 246 Clayton Road, Clayton, VIC, 3168, Australia.

Patients often experience emotional distress after acute coronary syndrome (ACS). These may lead to symptoms of depression or anxiety and greater morbidity/mortality. We sought to determine whether flowering plants in the coronary care ward reduced depressive and anxiety symptoms in these patients. Read More

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December 2018

The augment-and-modular-cage revision system for reconstruction of severe acetabular defects-two-year clinical and radiographic results.

Int Orthop 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedics and Traumatology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.

Purpose: Acetabular revision of failed total hip arthroplasty (THA) is often associated with severe bone loss. Therefore, a variety of revision implant systems has been developed during recent years, with the augment-and-modular-cage system being one of the newest additions to this portfolio. Together with biologic downsizing by means of impaction bone grafting, this uncemented system promises a high modularity and versatility to treat all acetabular defects up to Paprosky types IIIa and IIIb without pelvic discontinuity. Read More

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December 2018

Synthesis and crystal structure of double-three ring (D3R)-type cage siloxanes modified with dimethylsilanol groups.

Dalton Trans 2018 Dec 12. Epub 2018 Dec 12.

Department of Applied Chemistry, Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan. and Kagami Memorial Research Institute for Materials Science and Technology, Waseda University, 2-8-26 Nishiwaseda, Shinjuku-ku, Tokyo 169-0051, Japan.

The controlled assembly of molecular building blocks enables the rational design of nanomaterials. In this study, two types of cage-type oligosiloxanes with double-three ring (D3R) structures are modified with dimethylsilanol groups to form supramolecular assemblies. One is the siloxane cage derived from Si(OEt)4 (denoted as the Q6 cage), and the other is the organosiloxane cage derived from (EtO)3Si-CH2-Si(OEt)3 (denoted as the T6 cage). Read More

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December 2018

Pilot evaluation of an objective structured assessment of technical skills tool for chest tube insertion.

GMS J Med Educ 2018 15;35(4):Doc48. Epub 2018 Nov 15.

University of Heidelberg, Department of General, Visceral, and Transplantation Surgery, Heidelberg, Germany.

Chest tube insertion is a standard intervention for management of various injuries of the thorax. Efficient clinical training of this and similar bed-side procedures is equally demanded and improvable. Here, we propose a nouveau means of assessment and feedback using an Objective Structured Assessment of Technical Skills (OSATS) tool. Read More

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November 2018

Multiplex amplification refractory mutation system PCR (ARMS-PCR) provides convenient method for differentiation of canine parvovirus vaccine and field strains.

Virusdisease 2018 Dec 26;29(4):565-568. Epub 2018 Sep 26.

1Centre of Animal Disease Diagnosis and Research, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP 243122 India.

Vaccination with canine parvovirus-2 (CPV-2) modified live attenuated vaccine remains an effective control strategy for preventing parvovirus induced enteritis in dogs. Virus shedding is a common phenomenon few days after vaccination, possessing a diagnostic dilemma for accurate differentiation of CPV-2 vaccine and wild type field strains. Though several molecular approaches are available for differentiation, the present study focuses on a simple, rapid, cost-effective differentiating infected from vaccinated animals strategy employing ARMS-PCR for differentiation of CPV-2 vaccine and wild type field strains. Read More

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December 2018
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The Effect of Modified Biolasol Solution on the Efficacy of Storing Isolated Porcine Kidneys.

Biomed Res Int 2018 12;2018:7465435. Epub 2018 Nov 12.

"Biochefa" Pharmaceutical Research and Production Plant, Sosnowiec, Poland.

Biolasol is a newly developed solution for storing the liver, pancreas, kidneys, and heart by simple hypothermia. It exhibits high efficacy in maintaining structural and functional integrity of the graft prior to its transplantation. The solution was modified by the addition of ascorbic acid (0. Read More

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November 2018

Biomarker-based corticosteroid adjustment in severe asthma: a modified Delphi consensus.

ERJ Open Res 2018 Oct 7;4(4). Epub 2018 Dec 7.

Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.

http://ow.ly/sTrf30my3jw. Read More

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October 2018