2,543 results match your criteria Modern Rheumatology[Journal]


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Mod Rheumatol 2019 Apr 9. Epub 2019 Apr 9.

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http://dx.doi.org/10.1080/14397595.2018.1562101DOI Listing
April 2019
3 Reads

Comparison of median nerve stiffness with and without rheumatoid arthritis by ultrasound real-time tissue elastography: A propensity score matching study.

Mod Rheumatol 2019 Apr 5:1-8. Epub 2019 Apr 5.

b Department of Orthopaedic Surgery , Osaka City University Graduate School of Medicine , Osaka , Japan.

Objectives: This study aimed to compare median nerve stiffness measured by ultrasound real-time tissue elastography in patients with and without rheumatoid arthritis (RA and non-RA groups, respectively).

Methods: Altogether, 402 hands of 201 RA group and 222 hands of 111 non-RA group were included in the study. Ultrasonography was performed to evaluate the circumference, cross-sectional area (CSA) and strain ratio as an elasticity of the median nerve at the inlet level of the carpal tunnel and the proximal portion of the carpal tunnel inlet. Read More

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http://dx.doi.org/10.1080/14397595.2019.1602914DOI Listing
April 2019
9 Reads

Expressions of circadian clock genes represent disease activities of RA patients treated with biological DMARDs.

Mod Rheumatol 2019 Apr 3:1-17. Epub 2019 Apr 3.

a Department of Biophysics , Kobe University Graduate School of Health Sciences , Kobe 654-0142 , Japan.

Objective: Rheumatoid Arthritis (RA) is the autoimmune disease representing the circadian variations of symptoms such as morning stiffness of joints or increased production of cytokines around midnight. Clock genes have been reported to affect on the pathogenesis of RA, however, the detailed relation between clock genes and disease activities of RA has remained unclear.

Methods: In this study, 15 RA patients treated with bDMARDs were enrolled (TNF inhibitor, 5; IL-6 inhibitor, 5; CTLA4-IgG, 5). Read More

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http://dx.doi.org/10.1080/14397595.2019.1602242DOI Listing
April 2019
1 Read

Clinical features and human T-cell leukemia virus type-1 (HTLV-1) proviral load in HTLV-1-positive patients with rheumatoid arthritis: Baseline data in a single center cohort study.

Mod Rheumatol 2019 Apr 2:1-23. Epub 2019 Apr 2.

a Rheumatic and Collagen Disease Center, Sasebo Chuo Hospital , Sasebo , Japan.

Objective: Recently, Human T-cell leukemia virus type-1 proviral load (HTLV-1 PVL) has been evaluated as an important predictor of adult T-cell leukemia/lymphoma (ATL) in HTLV-1 carriers. We aimed to evaluate whether HTLV-1 PVL is also important for the development of ATL among HTLV-1-positive patients with rheumatoid arthritis (RA).

Methods: We established a cohort of 82 HTLV-1-positive RA patients between 2017 - 2018. Read More

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http://dx.doi.org/10.1080/14397595.2019.1602931DOI Listing
April 2019
4 Reads

Correction.

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Mod Rheumatol 2019 Apr 2. Epub 2019 Apr 2.

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http://dx.doi.org/10.1080/14397595.2019.1589965DOI Listing

Pharmaceutical immunoglobulins reduce neutrophil extracellular trap formation and ameliorate the development of MPO-ANCA-associated vasculitis.

Mod Rheumatol 2019 Apr 1:1-7. Epub 2019 Apr 1.

a Department of Medical Laboratory Science, Faculty of Health Sciences , Hokkaido University , Sapporo , Japan.

Objectives: Intravenous immunoglobulin (IVIG) therapy is effective against some autoimmune diseases. We examined the effects of pharmaceutical immunoglobulins on the development of MPO-ANCA-associated vasculitis (MPO-AAV).

Methods: Peripheral blood neutrophils were pretreated with 5 mg/ml sulfo-immunoglobulins (IVIG-S) and then exposed to 100 nM phorbol myristate acetate (PMA). Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2019.1
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http://dx.doi.org/10.1080/14397595.2019.1602292DOI Listing
April 2019
4 Reads

Association between preexisting lung involvements and the risk of diffuse alveolar hemorrhage in patients with microscopic polyangiitis: A multi-center retrospective cohort study.

Mod Rheumatol 2019 Apr 1:1-7. Epub 2019 Apr 1.

a Department of Inflammation and Immunology, Graduate School of Medical Science , Kyoto Prefectural University of Medicine , Kyoto , Japan.

Objectives: To identify the factors associated with the risk of diffuse alveolar hemorrhage (DAH) in patients with microscopic polyangiitis (MPA), focusing on other preexisting lung involvements such as interstitial lung disease (ILD) and airway disease.

Methods: In this retrospective cohort study, we analyzed consecutive patients with myeloperoxidase-antineutrophil cytoplasmic antibody-positive MPA who had undergone chest computed tomography (CT) before starting treatment between 2006 and 2016. Patients who already had DAH at initial CT imaging were excluded. Read More

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http://dx.doi.org/10.1080/14397595.2019.1601855DOI Listing
April 2019
3 Reads

Danaparoid is effective and safe for patients with obstetric antiphospholipid syndrome.

Mod Rheumatol 2019 Mar 29:1-6. Epub 2019 Mar 29.

a Department of Obstetrics and Gynecology , Nagoya City University, Graduate School of Medical Sciences , Nagoya , Japan.

Objectives: The objective is to evaluate whether danaparoid is effective in improving the live birth rate in patients with obstetric antiphospholipid syndrome (oAPS).

Methods: This prospective study included 91 pregnancies of 60 patients with oAPS diagnosed according to criteria of the International Congress on APS. Live birth rates, adverse pregnancies and perinatal outcomes were compared among patients treated with danaparoid and low dose aspirin (danaparoid group, LDA), unfractionated heparin (UFH) and LDA (UFH group) and LDA and/or prednisolone (LDA group). Read More

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http://dx.doi.org/10.1080/14397595.2019.1602241DOI Listing
March 2019
3 Reads

Effects of range of motion exercise of the metatarsophalangeal joint from 2-weeks after joint-preserving rheumatoid forefoot surgery.

Mod Rheumatol 2019 Mar 29:1-8. Epub 2019 Mar 29.

a Department of Rheumatology/Orthopaedics , National Hospital Organization, Osaka Minami Medical Center , Osaka , Japan.

Objectives: Joint-preserving rheumatoid forefoot surgery improves clinical outcomes, but postoperative range of motion (ROM) of the metatarsophalangeal (MTP) joint remains an issue. The objective of this study was to evaluate the effect of ROM exercise from the early period after lesser toe MTP joint-preserving surgery.

Methods: A retrospective, observational study of 22 rheumatoid arthritis patients who underwent modified metatarsal shortening offset osteotomy was completed. Read More

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http://dx.doi.org/10.1080/14397595.2019.1601853DOI Listing
March 2019
1 Read

Measurement of equivalence between the web and paper versions of the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire.

Mod Rheumatol 2019 Mar 29:1-5. Epub 2019 Mar 29.

a Department of Orthopaedic Surgery , Nagoya University Graduate School of Medicine , Nagoya , Japan.

Objectives: Digitised patient-reported outcome may be beneficial for physicians and patients. The Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) can only be completed with paper and pencil (pJHEQ). We newly developed a web version of the JHEQ (wJHEQ). Read More

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http://dx.doi.org/10.1080/14397595.2019.1592799DOI Listing

Impact of comorbidity rates of lumbar spondylosis, knee osteoarthritis, and osteoporosis on physical QOL and risk factors for poor physical QOL in middle-aged and elderly people.

Mod Rheumatol 2019 Mar 29:1-8. Epub 2019 Mar 29.

b Department of Rehabilitation , Kansai University of Welfare Sciences , Osaka , Japan.

Purpose: To examine effects of combined osteoporosis (P), knee osteoarthritis (K-OA), and lumbar spondylosis (L-OA) on quality of life (QOL), and identify risk factors for poor QOL.

Methods: 1021 subjects (440 males, 581 females, mean age: 63.4 years) were prospectively included. Read More

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http://dx.doi.org/10.1080/14397595.2019.1601839DOI Listing
March 2019
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Recognition of alpha-mannan by dectin 2 is essential for onset of Kawasaki disease-like murine vasculitis induced by Candida albicans cell-wall polysaccharide.

Mod Rheumatol 2019 Mar 29:1-8. Epub 2019 Mar 29.

a Department of Pathology , Toho University Ohashi Medical Center , Tokyo , Japan.

Objectives: Using a murine model of systemic Kawasaki disease (KD)-like vasculitis induced by Candida albicans cell-wall-derived mannan · β-glucan · protein complexes, the objective was to elucidate the relationships of β-glucan receptor dectin-1 (D1) and α-mannan receptor dectin-2 (D2) to the onset of that vasculitis.

Methods: The incidence and histological severity of vasculitis were compared among mice lacking the genes for D1 or D2 (i.e. Read More

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http://dx.doi.org/10.1080/14397595.2019.1601852DOI Listing
March 2019
1 Read

High melatonin levels are related to spinal ossification in patients with ankylosing spondylitis.

Mod Rheumatol 2019 Mar 29:1-6. Epub 2019 Mar 29.

c Department of Rheumatology , Zhongshan Hospital, Fudan University , Shanghai , China.

Objectives: To investigate associations of serum melatonin with spinal ossification and cytokines in ankylosing spondylitis (AS).

Methods: Serum was obtained from 52 AS patients and 25 healthy controls. Melatonin was measured by ELISA kit; bone morphogenetic protein (BMP)-2, dickkopf-related protein (Dkk)-1, IL-1β, IL-6, IL-17 and TNF-α concentrations were assayed using Luminex multiplex bead system. Read More

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http://dx.doi.org/10.1080/14397595.2019.1601854DOI Listing
March 2019
1 Read

Correction.

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Mod Rheumatol 2019 Mar 26. Epub 2019 Mar 26.

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http://dx.doi.org/10.1080/14397595.2019.1595173DOI Listing

The correlation between interleukin-34 and bone erosion under ultrasound in rheumatoid arthritis.

Mod Rheumatol 2019 Mar 17:1-7. Epub 2019 Mar 17.

a Department of Rheumatology , Huashan Hospital, Fudan University , Shanghai , China.

Background: Rheumatoid arthritis (RA) is a chronic inflammatory arthropathy characterized by excessive synovial hyperplasia and progressive joint destruction. Pro-inflammatory cytokines play major roles in the regulation of synovial inflammation. The contribution of interleukin-34 (IL-34) in RA pathogenesis has been strongly suggested in clinical studies. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2019.1
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http://dx.doi.org/10.1080/14397595.2019.1593576DOI Listing
March 2019
6 Reads

Differences of articular and extra-articular involvement in polymyalgia rheumatica: A comparison by whole-body FDG-PET/CT.

Mod Rheumatol 2019 Mar 7:1-7. Epub 2019 Mar 7.

c Department of Radiology , Fukuoka Memorial Hospital , Fukuoka , Japan.

Objectives: To clarify differences in incidences of articular and extra-articular involvement in patients with polymyalgia rheumatica (PMR) using FDG-PET/CT.

Methods: Twenty PMR patients were enrolled in this retrospective study. We compared frequency, degree, and patterns (diffuse or non-diffuse) of abnormal FDG accumulation in the proximal and distal articular structures (PAS, DAS), and extra-articular synovial structures (ESS). Read More

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http://dx.doi.org/10.1080/14397595.2019.1591065DOI Listing
March 2019
1 Read

Radiographic and clinical outcomes following etanercept monotherapy in Japanese methotrexate-naïve patients with active rheumatoid arthritis.

Mod Rheumatol 2019 Mar 6:1-10. Epub 2019 Mar 6.

e Immunology and Inflammation Medical Affairs , Pfizer Biopharmaceuticals Group, Pfizer Japan Inc. , Tokyo , Japan.

Objectives: Compare outcomes with methotrexate (MTX) or etanercept (ETN) monotherapy in Japanese patients with active rheumatoid arthritis (RA) who were MTX-naïve or with intolerance or inadequate response to prior MTX (MTX-IR).

Methods: Post hoc analysis of a phase 3 study comparing MTX, ETN 10 mg twice weekly, and ETN 25 mg twice weekly in Japanese patients with RA. Disease activity was evaluated using American College of Rheumatology (ACR) scores and 28-joint Disease Activity Score (DAS28), radiographic progression evaluated using van der Heijde's modified Total Sharp Score (mTSS), and functional status evaluated using Health Assessment Questionnaire Disability Index (HAQ-DI). Read More

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http://dx.doi.org/10.1080/14397595.2019.1589918DOI Listing
March 2019
7 Reads

Prevalence and clinical characteristics of overactive bladder in systemic sclerosis.

Mod Rheumatol 2019 Mar 5:1-5. Epub 2019 Mar 5.

a Department of Dermatology , Gunma University Graduate School of Medicine , Gunma , Japan.

Objectives: Overactive bladder (OAB) is a clinical diagnosis defined with the presence of urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence. Objective was to evaluate the demographic and clinical characteristics of Japanese systemic sclerosis (SSc) patients with OAB.

Methods: OAB was diagnosed by OAB symptom score (OABSS) in 104 Japanese SSc patients (93 women and 11 men). Read More

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http://dx.doi.org/10.1080/14397595.2019.1589913DOI Listing
March 2019
2 Reads

Prevalence, outcome and prognostic factors of neuropsychiatric systemic lupus erythematosus: A real world single center study.

Mod Rheumatol 2019 Mar 5:1-6. Epub 2019 Mar 5.

a Department of Rheumatology and Immunology, Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135) , Peking University People's Hospital , Beijing , P. R. China.

Objectives: To investigate the prevalence, outcome and prognostic factors of neuropsychiatric systemic lupus erythematosus (NPSLE).

Methods: SLE inpatients from 2005 to 2016 were included. Information on survival duration and causes of death was collected. Read More

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http://dx.doi.org/10.1080/14397595.2019.1589912DOI Listing
March 2019
5 Reads

Reduction in body cell mass as a predictor of osteoporosis: A cross-sectional study.

Mod Rheumatol 2019 Mar 5:1-6. Epub 2019 Mar 5.

a Department of Orthopaedic Surgery , Nagoya University Graduate School of Medicine , Nagoya , Japan.

Objectives: Improvement of nutritional status, which may help prevent osteoporosis, can be assessed using the body cell mass (BCM) index, measured by the bioelectrical impedance analysis (BIA). However, the relationship between BCM and osteoporosis is not clear. This cross-sectional study investigated the association between osteoporosis and four components of body composition, including BCM. Read More

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http://dx.doi.org/10.1080/14397595.2019.1589911DOI Listing
March 2019
1 Read

Efficacy and safety of adalimumab in Japanese patients with psoriatic arthritis and inadequate response to non-steroidal anti-inflammatory drugs (NSAIDs): A prospective, observational study.

Mod Rheumatol 2019 Mar 5:1-23. Epub 2019 Mar 5.

f Department of Dermatology and Plastic Surgery, Faculty of Life Sciences , Kumamoto University , Kumamoto , Japan.

Objective: To evaluate the efficacy and safety of adalimumab in psoriatic arthritis (PsA) patients in Japan.

Methods: In this open-label, single-arm study conducted at six sites from October 2014 to June 2016 (UMIN000016543), PsA patients (≥20 years old) with inadequate response to nonsteroidal anti-inflammatory drugs received adalimumab subcutaneously (80 mg initially, then 40 mg every other week; 24 weeks total). Primary endpoint was American College of Rheumatology 20% improvement (ACR20) response rate at week 12. Read More

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http://dx.doi.org/10.1080/14397595.2019.1589739DOI Listing
March 2019
3 Reads

Relationship of callosities of the forefoot with foot deformity, Health Assessment Questionnaire Disability Index, and joint damage score in patients with rheumatoid arthritis.

Mod Rheumatol 2019 Mar 5:1-6. Epub 2019 Mar 5.

c Department of Orthopedic Surgery , Tokyo Women's Medical University , Tokyo , Japan.

Objectives: We aimed to investigate the relationship of callosities of the forefoot with foot deformity, the Health Assessment Questionnaire Disability Index (HAQ-DI) and modified total Sharp score (TSS) in patients with rheumatoid arthritis (RA).

Methods: A total of 202 patients and 404 feet were enrolled. We examined the prevalence of callosities. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2019.1
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http://dx.doi.org/10.1080/14397595.2019.1589921DOI Listing
March 2019
8 Reads

Association of anti-cyclic citrullinated peptide antibody with clinical features in patients with psoriatic arthritis.

Mod Rheumatol 2019 Feb 22:1-8. Epub 2019 Feb 22.

a Department of Internal Medicine, Faculty of Medicine , University of Tsukuba , Ibaraki , Japan.

Background: Although anti-cyclic citrullinated peptide antibody (anti-CCP Ab) is reported to be found in 5-20% of patients with psoriatic arthritis (PsA), its clinical significance has not been elucidated.

Objective: To clarify the association of anti-CCP Ab with clinical features in PsA.

Methods: Patients were enrolled who fulfilled the classification criteria for psoriatic arthritis (CASPAR) criteria and visited our hospital. Read More

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http://dx.doi.org/10.1080/14397595.2019.1586085DOI Listing
February 2019
1 Read

Effects of forefoot arthroplasty on plantar pressure, pain, gait and disability in rheumatoid arthritis.

Mod Rheumatol 2019 Feb 22:1-4. Epub 2019 Feb 22.

a Department of Rehabilitation , Yokohama City University Medical Center , Kanagawa , Japan.

Objectives: The purpose of this study was to clarify the effect of forefoot arthroplasty on plantar pressure, pain, gait, and disability within 1 year after arthroplasty in patients with RA.

Methods: Eleven patients with RA who underwent forefoot arthroplasty completed this quasi-experimental study. Outcome measures were in-shoe plantar pressure, visual analog scale (VAS) for pain, temporal gait parameters, and modified Health Assessment Questionnaire (mHAQ), obtained preoperatively and at 4 and 12 months postoperatively. Read More

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http://dx.doi.org/10.1080/14397595.2019.1584951DOI Listing
February 2019

Safety and tolerability of anifrolumab, a monoclonal antibody targeting type I interferon receptor, in Japanese patients with systemic lupus erythematosus: A multicenter, phase 2, open-label study.

Mod Rheumatol 2019 Feb 22:1-8. Epub 2019 Feb 22.

i Global Medicine Division , AstraZeneca Pharmaceuticals , Gaithersburg , MD , USA.

Objectives: This study evaluated the safety and tolerability of anifrolumab, a monoclonal antibody targeting the type I interferon (IFN) receptor, in Japanese patients with moderate-to-severe systemic lupus erythematosus (SLE).

Methods: In this open-label, phase 2, dose-escalation study, patients received intravenous (IV) anifrolumab 100, 300, or 1000 mg every 4 weeks from days 29 to 337 (Stage 1). Patients who completed Stage 1 continued anifrolumab 300 mg every 4 weeks for 156 weeks (Stage 2). Read More

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http://dx.doi.org/10.1080/14397595.2019.1583833DOI Listing
February 2019

Does microbiome contribute to HLA-B52-positive Takayasu arteritis?

Mod Rheumatol 2019 Feb 22:1-5. Epub 2019 Feb 22.

a Division of Rheumatology, Department of Internal Medicine , Keio University School of Medicine , Tokyo , Japan.

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http://dx.doi.org/10.1080/14397595.2019.1584146DOI Listing
February 2019
1 Read

Safety and tolerability of sifalimumab, an anti-interferon-α monoclonal antibody, in Japanese patients with systemic lupus erythematosus: A multicenter, phase 2, open-label study.

Mod Rheumatol 2019 Feb 21:1-8. Epub 2019 Feb 21.

i AstraZeneca , Gaithersburg , MD , USA.

Objectives: To evaluate the safety of sifalimumab in Japanese patients with systemic lupus erythematosus (SLE).

Methods: This phase 2, open-label study consisted of a 52-week initial stage (Stage I) and a long-term extension (Stage II). In Stage I, sequential cohorts of patients received ascending doses of sifalimumab (intravenous [IV] 1. Read More

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http://dx.doi.org/10.1080/14397595.2019.1583832DOI Listing
February 2019
1 Read

Anti-cyclic citrullinated peptide antibody titers decrease in rheumatoid arthritis patients treated with tocilizumab: A pilot study.

Mod Rheumatol 2019 Feb 21:1-6. Epub 2019 Feb 21.

a Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine , Hokkaido University , Sapporo , Japan.

Objectives: To analyze the effects of tocilizumab on peripheral B-cell subpopulation and its ability to produce anti-cyclic citrullinated peptide (CCP) antibody in patients with rheumatoid arthritis (RA).

Methods: Thirteen consecutive RA patients initiated with tocilizumab were enrolled in our prospective study. Anti-CCP antibody titers and clinical parameters were evaluated during treatment. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2019.1
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http://dx.doi.org/10.1080/14397595.2019.1583784DOI Listing
February 2019
9 Reads

Activated neutrophil carbamylates albumin via the release of myeloperoxidase and reactive oxygen species regardless of NETosis.

Mod Rheumatol 2019 Feb 21:1-14. Epub 2019 Feb 21.

a Department of Rheumatology and Clinical Immunology , Graduate School of Medicine, Kyoto University , 54 Shogoin-Kawahara-cho, Sakyo-ku , Kyoto , Japan.

Objective: An anti-carbamylated albumin antibody was detected in rheumatoid arthritis patients, and its presence was associated with serum myeloperoxidase (MPO) levels, as we reported previously. Since MPO is a key enzyme for carbamylation and is released by neutrophil extracellular traps (NETs), we aimed to demonstrate that NETosis induces carbamylation.

Methods: Human neutrophils were isolated from a healthy donor, pre-treated with or without diphenyleneiodonium (DPI, an inhibitor for the generation of reactive oxygen species (ROS)), Cl-amidine (a peptidylarginine deiminase inhibitor), 4-aminobenzoic acid hydrazide (4-ABAH, an MPO inhibitor), or GW311616A (a neutrophil elastase inhibitor), and incubated for 8 hours with or without phorbol 12-myristate 13-acetate (PMA). Read More

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http://dx.doi.org/10.1080/14397595.2019.1583819DOI Listing
February 2019
1 Read

Effect of biological agents on synovial tissues from patients with rheumatoid arthritis.

Mod Rheumatol 2019 Feb 21:1-5. Epub 2019 Feb 21.

a Department of Orthopaedic Surgery , Toho University Omori Medical Center , Tokyo , Japan.

Objectives: To compare the inflammation of synovium before and after biological agents in the patients with rheumatoid arthritis (RA) and to investigate the association between synovial histopathology and disease activity.

Methods: Synovial tissues were obtained during operations from 34 patients before and after treatment with biological agents. The synovial tissue was evaluated using hematoxylin and eosin staining. Read More

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http://dx.doi.org/10.1080/14397595.2019.1583783DOI Listing
February 2019
1 Read

Safety profile of baricitinib in Japanese patients with active rheumatoid arthritis with over 1.6 years median time in treatment: An integrated analysis of Phases 2 and 3 trials.

Mod Rheumatol 2019 Feb 20:1-8. Epub 2019 Feb 20.

g First Department of Internal Medicine, School of Medicine , University of Occupational and Environmental Health , Kitakyushu , Japan.

Objectives: Baricitinib is a selective oral inhibitor of JAK1/JAK2 for patients with moderately-to-severely active rheumatoid arthritis (RA). Baricitinib's safety profile in Japanese patients was evaluated using six studies (five Ph2/Ph3 trials, one long-term extension study through 01 September 2016) from an integrated database (nine RA studies).

Methods: Incidence rates (IRs) or exposure-adjusted IRs (EAIRs) of adverse events (AEs) per 100 patient-years (PY) were calculated using data which included RA patients exposed to any baricitinib dose. Read More

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http://dx.doi.org/10.1080/14397595.2019.1583711DOI Listing
February 2019
1 Read

Serum cystatin C level can be an early predictor in community-living people? A clinical question to the conclusion.

Authors:
Ichiro Yoshii

Mod Rheumatol 2019 Feb 19:1-2. Epub 2019 Feb 19.

a Department of Rheumatology and Musculoskeletal Medicine , Yoshii Hospital , Kochi , Japan.

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http://dx.doi.org/10.1080/14397595.2019.1583710DOI Listing
February 2019

The diagnostic utility of submandibular gland sonography and labial salivary gland biopsy in IgG4-related dacryoadenitis and sialadenitis: Its potential application to the diagnostic criteria.

Mod Rheumatol 2019 Mar 4:1-6. Epub 2019 Mar 4.

a Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science , Kyushu University , Fukuoka , Japan.

Objectives: In this study, we investigated the diagnostic utility of submandibular gland (SMG) sonography and labial salivary gland (LSG) biopsy as a less invasive procedure for diagnosing IgG4-related dacryoadenitis and sialadenitis (IgG4-DS) Methods: Sixty-eight patients with suspected IgG4-DS by presenting swelling of elevated serum IgG (>1747 mg/dl) and/or swelling glands underwent SMG sonography, LSG biopsy and measurement for serum IgG4. SMG sonographic diagnosis was determined by the following characteristic changes; 'hypoechoic areas of a nodal pattern with high vascularity' and/or 'hypoechoic areas of a reticular pattern in the superficial part'.

Results: Thirty-one patients were diagnosed with IgG4-DS, 5 with IgG4-RD unaccompanied by lacrimal and salivary gland lesions, 28 with Sjögren's syndrome, and 4 with malignant lymphoma. Read More

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http://dx.doi.org/10.1080/14397595.2019.1576271DOI Listing
March 2019
3 Reads

Vitamin D insufficiency and deficiency are associated with a higher level of serum uric acid: A systematic review and meta-analysis.

Mod Rheumatol 2019 Mar 4:1-6. Epub 2019 Mar 4.

c Department of Research and Development, Faculty of Medicine Siriraj Hospital, Clinical Epidemiology Unit , Mahidol University , Bangkok , Thailand.

Introduction/objectives: Several epidemiological studies have suggested that patients with vitamin D insufficiency and deficiency tend to have a higher level of serum uric acid compared with those with adequate vitamin D level although the results were inconsistent across the studies. The current systematic review and meta-analysis was conducted with the aim to summarize all the available data.

Methods: A systematic review was conducted using MEDLINE and EMBASE database from inception to May 2018 to identify all studies that compared the level of serum uric acid between individuals with normal vitamin D level and patients with vitamin D insufficiency/deficiency. Read More

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http://dx.doi.org/10.1080/14397595.2019.1575000DOI Listing

Interleukin-6 in juvenile idiopathic arthritis.

Authors:
Shinji Akioka

Mod Rheumatol 2019 Mar;29(2):275-286

a Department of Pediatrics , Kyoto Prefectural University of Medicine , Kyoto , Japan.

Juvenile idiopathic arthritis (JIA) is a chronic childhood arthritis. Its pathogenesis is very complicated, with the involvement of not only immune cells but various types of parenchymal cells, and is affected by both genetic and environmental predispositions. The clinical spectrum from inflammation to related conditions is largely mediated by cytokines including interleukin (IL)-6. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2019.1
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http://dx.doi.org/10.1080/14397595.2019.1574697DOI Listing
March 2019
5 Reads

Major salivary gland enlargement in IgG4-related disease is associated with multiorgan involvement and higher basal disease activity.

Mod Rheumatol 2019 Jan 24:1-5. Epub 2019 Jan 24.

a Department of Immunology and Rheumatology , Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , Mexico City , Mexico.

Objective: To evaluate if major salivary gland enlargement in patients with IgG4-related disease (IgG4-RD) is associated with systemic involvement.

Methods: We included 47 patients with diagnosis of IgG4-RD. We retrospectively collected demographics, organ involvement, disease activity and damage assessed by the IgG4-RD Responder Index (IgG4-RD RI) and treatment. Read More

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http://dx.doi.org/10.1080/14397595.2019.1572575DOI Listing
January 2019

IgG4-related disease - A new disease entity developed in the twenty-first century.

Authors:
Tsuneyo Mimori

Mod Rheumatol 2019 03 19;29(2):213. Epub 2019 Feb 19.

a Department of Rheumatology and Clinical Immunology, Graduate School of Medicine , Kyoto University , Kyoto , Japan.

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http://dx.doi.org/10.1080/14397595.2019.1573789DOI Listing

Efficacy of iguratimod vs. salazosulfapyridine as the first-line csDMARD for rheumatoid arthritis.

Mod Rheumatol 2019 Mar 4:1-10. Epub 2019 Mar 4.

a Department of Hematology and Rheumatology , School of Medicine, Kindai University , Osaka , Japan.

Objectives: We retrospectively evaluated the retention rate and clinical responses following treatment for rheumatoid arthritis (RA) with iguratimod (IGU) vs. salazosulfapyridine (SASP) as the first-line conventional synthetic disease-modifying antirheumatic drug (csDMARD).

Methods: We analyzed 197 RA patients who were treated with IGU or SASP as the initial treatment in the 3-year study period. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2019.1
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http://dx.doi.org/10.1080/14397595.2019.1572267DOI Listing
March 2019
13 Reads

Analysis of allergic reaction in IgG4-related disease.

Mod Rheumatol 2019 Jan 24:1-3. Epub 2019 Jan 24.

a Department of Rheumatology and Clinical Immunology , Sapporo Medical University, School of Medicine , Sapporo , Japan.

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https://www.tandfonline.com/doi/full/10.1080/14397595.2019.1
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http://dx.doi.org/10.1080/14397595.2019.1572488DOI Listing
January 2019
8 Reads

Impact of combining medial capsule interposition with modified scarf osteotomy for hallux valgus.

Mod Rheumatol 2019 Jan 24:1-7. Epub 2019 Jan 24.

a Department of Orthopaedic Surgery , Graduate School of Medicine, Osaka University , Osaka, Japan.

Objectives: To clarify the effect of combining medial capsule interposition with modified scarf osteotomy for hallux valgus.

Methods: A multicenter, retrospective study included 64 cases [59 osteoarthritis patients (excluding rheumatoid arthritis); age 68.8 years, range 40-93 years] of modified scarf osteotomy which were performed from 2013 to 2017 and followed for 26. Read More

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http://dx.doi.org/10.1080/14397595.2019.1572261DOI Listing
January 2019
3 Reads

Difference in immunohistochemical characteristics between Takayasu arteritis and giant cell arteritis: It may be better to distinguish them in the same age.

Mod Rheumatol 2019 Jan 21:1-10. Epub 2019 Jan 21.

a Department of Molecular Pathology , Tokyo Medical University , Tokyo , Japan.

Objectives: This study aimed to compare Takayasu arteritis (TAK) with giant cell arteritis (GCA) through immunohistochemistry principally of inflammatory cells; these two disorders may be on the spectrum within a single disease state.

Methods: Nine TAK and 5 GCA surgically resected vessel specimens were selected. TAK specimen was divided into each three acute-, chronic-, and healed-phase samples based on intimal and adventitial thickening. Read More

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http://dx.doi.org/10.1080/14397595.2019.1570999DOI Listing
January 2019
5 Reads

Age and quality of life in patients with rheumatoid arthritis treated with biologic agents.

Mod Rheumatol 2019 Jan 3:1-6. Epub 2019 Jan 3.

a Division of Rheumatology, Department of Medicine , Showa University School of Medicine , Tokyo , Japan.

Objectives: This study aimed to assess the relationship between age and quality of life (QOL) in patients with rheumatoid arthritis (RA) after treatment with biologic agents.

Methods: We recruited 153 patients with RA treated with biologic agents at three hospitals of Showa University from 2005 to 2016 for this retrospective cohort study. Patients were divided into two groups-aged 65 years and older (elderly group) and aged under 65 years (adult group). Read More

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http://dx.doi.org/10.1080/14397595.2018.1551274DOI Listing
January 2019
5 Reads

Neutrophil lymphocyte ratio in patients with ankylosing spondylitis: A systematic review and meta-analysis.

Mod Rheumatol 2019 Jan 3:1-8. Epub 2019 Jan 3.

a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , China.

Objective: The aim of this meta-analysis was to investigate the association of neutrophil lymphocyte ratio (NLR) with AS (ankylosing spondylitis) patients.

Methods: PubMed, Web of Science, Cochrane Library, Elsevier Science Direct and Google Scholar databases (up to 30 September 2018) were searched to collect all pertinent articles. The pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by the random effects model. Read More

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http://dx.doi.org/10.1080/14397595.2018.1564165DOI Listing
January 2019
1 Read
2.206 Impact Factor

Italian consensus recommendations for the management of hepatitis C infection in patients with rheumatoid arthritis.

Mod Rheumatol 2019 Jan 22:1-8. Epub 2019 Jan 22.

c Rheumatology Unit , L. Sacco University Hospital , Milan , Italy.

Objectives: The recent introduction of direct-acting antiviral agents (DAAs) which can eliminate Hepatitis C virus (HCV) had revolutionized the treatment of HCV infections also in a complex clinical setting such as the patients with rheumatoid arthritis (RA). HCV elimination is also opportune due to the availability of more efficient immunosuppressive drugs, whose effect on the course of HCV infection is largely unknown.

Methods: Consensus process was endorsed by the Italian Society of Rheumatology (SIR) and the Italian Society of Infectious and Tropical Diseases (SIMIT) to review the available evidence and produce practical, hospital-wide recommendations. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2018.1
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http://dx.doi.org/10.1080/14397595.2018.1558918DOI Listing
January 2019
24 Reads

Age at the time of hip fracture in patients with rheumatoid arthritis is 4 years greater than it was 10 years before, but is still younger than that of the general population.

Mod Rheumatol 2018 Dec 20:1-6. Epub 2018 Dec 20.

b Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine , Niigata University Graduate School of Medical and Dental Sciences , Niigata , Japan.

Objective: To investigate the characteristics of hip fractures in patients with rheumatoid arthritis (RA).

Methods: Between 2012 and 2015, 789 hip fractures were treated at our hospital. Patients with RA were checked and their characteristics were compared with data recorded 10 years before, and with the general population. Read More

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http://dx.doi.org/10.1080/14397595.2018.1561351DOI Listing
December 2018
2 Reads

Treatment consensus for management of polymyositis and dermatomyositis among rheumatologists, neurologists and dermatologists.

Mod Rheumatol 2019 Jan 19;29(1):1-19. Epub 2018 Dec 19.

l Department of Internal Medicine , Faculty of Medicine, University of Tsukuba , Ibaraki , Japan.

Although rheumatologists, neurologists and dermatologists see patients with polymyositis (PM) and dermatomyositis (DM), their management appears to vary depending on the physician's specialty. The aim of the present study was to establish the treatment consensus among specialists of the three fields to standardize the patient care. We formed a research team supported by a grant from the Ministry of Health, Labor and Welfare, Japan. Read More

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http://dx.doi.org/10.1080/14397595.2018.1521185DOI Listing
January 2019
2 Reads

Associated factors with adherence to standard exercise therapy and health-related quality of life in Chinese patients with ankylosing spondylitis.

Mod Rheumatol 2018 Dec 18:1-6. Epub 2018 Dec 18.

b Research Center of Gerontology and Longevity , Affiliated Hospital of Nantong University , Nantong , China.

Objectives: The aim of this study is to assess the current situations of standard exercise treatment and predictors of non-standard exercise in Chinese patients with ankylosing spondylitis (AS). An analysis of the effect of standard exercise on health-related quality of life (HR-QoL) was also conducted.

Methods: In the cross-sectional study, a total of 259 AS patients were constantly invited to participate in this study and complete the questionnaire under the researchers' supervision in a clinical setting including sociodemographic variables, clinical variables, psychological variables, and HR-QoL. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2018.1
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http://dx.doi.org/10.1080/14397595.2018.1559966DOI Listing
December 2018
4 Reads
2.206 Impact Factor

The benefits and prospects of interleukin-6 inhibitor on systemic sclerosis.

Authors:
Yoshihito Shima

Mod Rheumatol 2019 Mar 6;29(2):294-301. Epub 2019 Feb 6.

a Department of Thermo-therapeutics for vascular dysfunction, Clinical Immunology , Osaka University Graduate School of Medicine , Osaka , Japan.

Systemic sclerosis (SSc) is a connective tissue disease, the pathogenesis of which is thought to involve interleukin-6 (IL-6), an inflammatory cytokine. This is based on findings of its concentration in patient serum, the results of an IL-6 suppression experiment in an animal model, and the results of a pilot study using IL-6 receptor antibody. However, it appears that a number of factors are involved in the pathology of SSc depending on the state of disease progression. Read More

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http://dx.doi.org/10.1080/14397595.2018.1559909DOI Listing

"IL-6 is a treatment target for a variety of immune diseases"- The benefit and prospect of IL-6 inhibitor.

Authors:
Yutaka Kawahito

Mod Rheumatol 2019 03 1;29(2):257. Epub 2019 Feb 1.

a Inflammation and Immunology , Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto , Japan.

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http://dx.doi.org/10.1080/14397595.2018.1559783DOI Listing

Potential therapeutics for antiphospholipid antibody associated thrombocytopenia: a systematic review and meta-analysis.

Mod Rheumatol 2018 Dec 17:1-21. Epub 2018 Dec 17.

a Department of Rheumatology, Nephrology and Endocrinology, Faculty of Medicine and Graduate School of Medicine , Hokkaido University , Sapporo , Japan.

Objectives: Thrombocytopenia is frequently observed in antiphospholipid antibody (aPL) carriers. Due to the paradoxical risks of thrombosis and hemorrhage, the management of aPL-associated thrombocytopenia (APAT) is often deductive. We aimed to investigate the efficacy and safety of therapeutic approaches for APAT through a systematic review. Read More

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http://dx.doi.org/10.1080/14397595.2018.1558934DOI Listing
December 2018