2,511 results match your criteria Modern Rheumatology[Journal]


The diagnostic utility of submandibular gland sonography and labial salivary gland biopsy in IgG4-related dacryoadenitis and sialadenitis: its potential application to the diagnostic criteria.

Mod Rheumatol 2019 Jan 30:1-13. Epub 2019 Jan 30.

a Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science , Kyushu University , Fukuoka , Japan.

Objectives: In this study, we investigated the diagnostic utility of submandibular gland (SMG) sonography and labial salivary gland (LSG) biopsy as a less invasive procedure for diagnosing IgG4-related dacryoadenitis and sialadenitis (IgG4-DS) Methods: Sixty-eight patients with suspected IgG4-DS by presenting swelling of elevated serum IgG (>1747 mg/dl) and/or swelling glands underwent SMG sonography, LSG biopsy and measurement for serum IgG4. SMG sonographic diagnosis was determined by the following characteristic changes; "hypoechoic areas of a nodal pattern with high vascularity" and/or "hypoechoic areas of a reticular pattern in the superficial part".

Results: Thirty-one patients were diagnosed with IgG4-DS, 5 with IgG4-RD unaccompanied by lacrimal and salivary gland lesions, 28 with Sjögren's syndrome, and 4 with malignant lymphoma. Read More

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http://dx.doi.org/10.1080/14397595.2019.1576271DOI Listing
January 2019
1 Read

Vitamin D Insufficiency and Deficiency are Associated with a Higher Level of Serum Uric Acid: A Systematic Review and Meta-analysis.

Mod Rheumatol 2019 Jan 28:1-15. Epub 2019 Jan 28.

c Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital , Mahidol University , Bangkok , Thailand.

Introduction/objectives: Several epidemiological studies have suggested that patients with vitamin D insufficiency and deficiency tend to have a higher level of serum uric acid compared with those with adequate vitamin D level although the results were inconsistent across the studies. The current systematic review and meta-analysis was conducted with the aim to summarize all the available data.

Method: A systematic review was conducted using MEDLINE and EMBASE database from inception to May 2018 to identify all studies that compared the level of serum uric acid between individuals with normal vitamin D level and patients with vitamin D insufficiency/deficiency. Read More

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http://dx.doi.org/10.1080/14397595.2019.1575000DOI Listing
January 2019

Interleukin-6 in juvenile idiopathic arthritis.

Authors:
Shinji Akioka

Mod Rheumatol 2019 Jan 28:1-30. Epub 2019 Jan 28.

a Department of Pediatrics , Kyoto Prefectural University of Medicine , Kyoto Japan.

Juvenile idiopathic arthritis (JIA) is a chronic childhood arthritis. Its pathogenesis is very complicated, with the involvement of not only immune cells but various types of parenchymal cells, and is affected by both genetic and environmental predispositions. The clinical spectrum from inflammation to related conditions is largely mediated by cytokines including interleukin (IL)-6. Read More

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http://dx.doi.org/10.1080/14397595.2019.1574697DOI Listing
January 2019

Major salivary gland enlargement in IgG4-related disease is associated with multiorgan involvement and higher basal disease activity.

Mod Rheumatol 2019 Jan 24:1-15. Epub 2019 Jan 24.

a Department of Immunology and Rheumatology , Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , Mexico City , Mexico.

Objective: To evaluate if major salivary gland enlargement in patients with IgG4-related disease (IgG4-RD) is associated with systemic involvement.

Methods: We included 47 patients with diagnosis of IgG4-RD. We retrospectively collected demographics, organ involvement, disease activity and damage assessed by the IgG4-RD Responder Index (IgG4-RD RI) and treatment. Read More

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http://dx.doi.org/10.1080/14397595.2019.1572575DOI Listing
January 2019

IgG4-related disease - a new disease entity developed in the 21st century.

Authors:
Tsuneyo Mimori

Mod Rheumatol 2019 Jan 24:1-2. Epub 2019 Jan 24.

a Department of Rheumatology and Clinical Immunology , Graduate School of Medicine, Kyoto University , Kyoto , Japan.

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http://dx.doi.org/10.1080/14397595.2019.1573789DOI Listing
January 2019

Efficacy of iguratimod versus salazosulfapyridine as the first-line csDMARD for rheumatoid arthritis.

Mod Rheumatol 2019 Jan 24:1-23. Epub 2019 Jan 24.

a Department of Hematology and Rheumatology , Kindai University School of Medicine , Osaka , Japan.

Objectives: We retrospectively evaluated the retention rate and clinical responses following treatment for rheumatoid arthritis (RA) with iguratimod (IGU) versus salazosulfapyridine (SASP) as the first-line conventional synthetic disease-modifying antirheumatic drug (csDMARD).

Methods: We analyzed 197 RA patients who were treated with IGU or SASP as the initial treatment in the 3-year study period. The retention rate, clinical response, the dosage and percent user of prednisolone (PSL), and safety profiles were evaluated. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2019.1
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http://dx.doi.org/10.1080/14397595.2019.1572267DOI Listing
January 2019
10 Reads

Analysis of allergic reaction in IgG4-related disease.

Mod Rheumatol 2019 Jan 24:1-7. Epub 2019 Jan 24.

a Department of Rheumatology and Clinical Immunology , Sapporo Medical University, School of Medicine , Sapporo , Japan.

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https://www.tandfonline.com/doi/full/10.1080/14397595.2019.1
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http://dx.doi.org/10.1080/14397595.2019.1572488DOI Listing
January 2019
2 Reads

Impact of combining medial capsule interposition with modified scarf osteotomy for hallux valgus.

Mod Rheumatol 2019 Jan 24:1-15. Epub 2019 Jan 24.

a Department of Orthopaedic Surgery , Osaka University Graduate School of Medicine , Osaka , Japan.

Objectives: To clarify the effect of combining medial capsule interposition with modified scarf osteotomy for hallux valgus.

Methods: A multicenter, retrospective study included 64 cases [59 osteoarthritis patients (excluding rheumatoid arthritis); age 68.8 years, range 40 to 93 years) of modified scarf osteotomy which were performed from 2013 to 2017 and followed for 26. Read More

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http://dx.doi.org/10.1080/14397595.2019.1572261DOI Listing
January 2019
2 Reads

Difference in immunohistochemical characteristics between Takayasu arteritis and giant cell arteritis: it may be better to distinguish them in the same age.

Mod Rheumatol 2019 Jan 21:1-23. Epub 2019 Jan 21.

a Department of Molecular Pathology , Tokyo Medical University , Tokyo , Japan.

Objectives This study aimed to compare Takayasu arteritis (TAK) with giant cell arteritis (GCA) through immunohistochemistry principally of inflammatory cells; these 2 disorders may be on the spectrum within a single disease state. Methods Nine TAK and 5 GCA surgically-resected vessel specimens were selected. TAK specimen was divided into each 3 acute-, chronic-, and healed-phase samples based on intimal and adventitial thickening. Read More

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http://dx.doi.org/10.1080/14397595.2019.1570999DOI Listing
January 2019
1 Read

Age and quality of life in patients with rheumatoid arthritis treated with biologic agents.

Mod Rheumatol 2019 Jan 3:1-6. Epub 2019 Jan 3.

a Division of Rheumatology, Department of Medicine , Showa University School of Medicine , Tokyo , Japan.

Objectives: This study aimed to assess the relationship between age and quality of life (QOL) in patients with rheumatoid arthritis (RA) after treatment with biologic agents.

Methods: We recruited 153 patients with RA treated with biologic agents at three hospitals of Showa University from 2005 to 2016 for this retrospective cohort study. Patients were divided into two groups-aged 65 years and older (elderly group) and aged under 65 years (adult group). Read More

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http://dx.doi.org/10.1080/14397595.2018.1551274DOI Listing
January 2019
3 Reads

Neutrophil lymphocyte ratio in Patients with Ankylosing Spondylitis: A Systematic Review and Meta-Analysis.

Mod Rheumatol 2019 Jan 3:1-19. Epub 2019 Jan 3.

a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , China.

Objective: The aim of this meta-analysis was to investigate the association of neutrophil lymphocyte ratio (NLR) with AS (ankylosing spondylitis) patients.

Methods: PubMed, Web of Science, Cochrane Library, Elsevier Science Direct and Google Scholar databases (up to 30 Sep, 2018) were searched to collect all pertinent articles. The pooled standard mean difference(SMD) with 95% confidence interval (CI) was calculated by the random effects model. Read More

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http://dx.doi.org/10.1080/14397595.2018.1564165DOI Listing
January 2019
1 Read
2.206 Impact Factor

Italian consensus recommendations for the management of hepatitis C infection in patients with rheumatoid arthritis.

Mod Rheumatol 2018 Dec 22:1-8. Epub 2018 Dec 22.

c Infectious Diseases Unit , University of Milano, Luigi Sacco Hospital , Milan.

Objectives: The recent introduction of direct-acting antiviral agents (DAAs) which can eliminate Hepatitis C virus (HCV) had revolutionized the treatment of HCV infections also in a complex clinical setting such as the patients with rheumatoid arthritis (RA). HCV elimination is also opportune due to the availability of more efficient immunosuppressive drugs, whose effect on the course of HCV infection is largely unknown.

Methods: Consensus process was endorsed by the Italian Society of Rheumatology (SIR) and the Italian Society of Infectious and Tropical Diseases (SIMIT) to review the available evidence and produce practical, hospital-wide recommendations. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2018.1
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http://dx.doi.org/10.1080/14397595.2018.1558918DOI Listing
December 2018
8 Reads

Age at the time of hip fracture in patients with rheumatoid arthritis is 4 years greater than it was 10 years before, but is still younger than that of the general population.

Mod Rheumatol 2018 Dec 20:1-6. Epub 2018 Dec 20.

b Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine , Niigata University Graduate School of Medical and Dental Sciences , Niigata , Japan.

Objective: To investigate the characteristics of hip fractures in patients with rheumatoid arthritis (RA).

Methods: Between 2012 and 2015, 789 hip fractures were treated at our hospital. Patients with RA were checked and their characteristics were compared with data recorded 10 years before, and with the general population. Read More

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http://dx.doi.org/10.1080/14397595.2018.1561351DOI Listing
December 2018
1 Read

Treatment consensus for management of polymyositis and dermatomyositis among rheumatologists, neurologists and dermatologists.

Mod Rheumatol 2019 Jan 19;29(1):1-19. Epub 2018 Dec 19.

l Department of Internal Medicine , Faculty of Medicine, University of Tsukuba , Ibaraki , Japan.

Although rheumatologists, neurologists and dermatologists see patients with polymyositis (PM) and dermatomyositis (DM), their management appears to vary depending on the physician's specialty. The aim of the present study was to establish the treatment consensus among specialists of the three fields to standardize the patient care. We formed a research team supported by a grant from the Ministry of Health, Labor and Welfare, Japan. Read More

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http://dx.doi.org/10.1080/14397595.2018.1521185DOI Listing
January 2019
1 Read

Associated factors with adherence to standard exercise therapy and health-related quality of life in Chinese patients with ankylosing spondylitis.

Mod Rheumatol 2018 Dec 18:1-6. Epub 2018 Dec 18.

b Research Center of Gerontology and Longevity , Affiliated Hospital of Nantong University , Nantong , China.

Objectives: The aim of this study is to assess the current situations of standard exercise treatment and predictors of non-standard exercise in Chinese patients with ankylosing spondylitis (AS). An analysis of the effect of standard exercise on health-related quality of life (HR-QoL) was also conducted.

Methods: In the cross-sectional study, a total of 259 AS patients were constantly invited to participate in this study and complete the questionnaire under the researchers' supervision in a clinical setting including sociodemographic variables, clinical variables, psychological variables, and HR-QoL. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2018.1
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http://dx.doi.org/10.1080/14397595.2018.1559966DOI Listing
December 2018
3 Reads
2.206 Impact Factor

The benefits and prospects of interleukin-6 inhibitor on systemic sclerosis.

Authors:
Yoshihito Shima

Mod Rheumatol 2018 Dec 18:1-8. Epub 2018 Dec 18.

a Department of Thermo-therapeutics for vascular dysfunction, Clinical Immunology , Osaka University Graduate School of Medicine , Osaka , Japan.

Systemic sclerosis (SSc) is a connective tissue disease, the pathogenesis of which is thought to involve interleukin-6 (IL-6), an inflammatory cytokine. This is based on findings of its concentration in patient serum, the results of an IL-6 suppression experiment in an animal model, and the results of a pilot study using IL-6 receptor antibody. However, it appears that a number of factors are involved in the pathology of SSc depending on the state of disease progression. Read More

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http://dx.doi.org/10.1080/14397595.2018.1559909DOI Listing
December 2018

"IL-6 is a treatment target for a variety of immune diseases"- The benefit and prospect of IL-6 inhibitor.

Authors:
Yutaka Kawahito

Mod Rheumatol 2018 Dec 18. Epub 2018 Dec 18.

a Inflammation and Immunology , Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto , Japan.

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http://dx.doi.org/10.1080/14397595.2018.1559783DOI Listing
December 2018

Potential therapeutics for antiphospholipid antibody associated thrombocytopenia: a systematic review and meta-analysis.

Mod Rheumatol 2018 Dec 17:1-21. Epub 2018 Dec 17.

a Department of Rheumatology, Nephrology and Endocrinology, Faculty of Medicine and Graduate School of Medicine , Hokkaido University , Sapporo , Japan.

Objectives: Thrombocytopenia is frequently observed in antiphospholipid antibody (aPL) carriers. Due to the paradoxical risks of thrombosis and hemorrhage, the management of aPL-associated thrombocytopenia (APAT) is often deductive. We aimed to investigate the efficacy and safety of therapeutic approaches for APAT through a systematic review. Read More

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http://dx.doi.org/10.1080/14397595.2018.1558934DOI Listing
December 2018

The front line of research into immunoglobin (Ig) G4-related disease - Do autoantibodies cause IgG4-RD?

Mod Rheumatol 2018 Dec 17:1-11. Epub 2018 Dec 17.

d First Department of Internal Medicine , University of Occupational and Environmental Health , Kitakyushu , Japan.

IgG4-related disease (IgG4-RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. Although IgG4-RD is attracting strong attention as a new clinical entity, the pathogenesis of IgG4-RD and the roles of IgG4 are still unknown. Recently, self-antigens including Laminin 511 E8, Galectin-3 and Annexin A11, have been reported from one to the next as autoantigens which may be involved in the pathogenesis of IgG4-RD. Read More

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http://dx.doi.org/10.1080/14397595.2018.1558519DOI Listing
December 2018

Behcet's disease in Iran: Analysis of 7641 cases.

Mod Rheumatol 2018 Dec 17:1-8. Epub 2018 Dec 17.

a Behcet's Disease Unit, Rheumatology Research Center, Shariati Hospital , Tehran University of Medical Sciences , Tehran , Iran.

Objective: To analyze Behcet's Disease (BD) in Iran, from 1975 to 2018, and compare to 35 large/small reports from other countries.

Methods: Patients from all over Iran, when suspected, were sent to the BD Unit. The diagnosis was done by expert opinion. Read More

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http://dx.doi.org/10.1080/14397595.2018.1558752DOI Listing
December 2018
3 Reads

Remission of proteinuria under therapeutic intervention and the renal outcomes in Japanese patients with lupus nephritis class III and IV.

Mod Rheumatol 2018 Dec 17:1-7. Epub 2018 Dec 17.

a Division of Nephrology and Hypertension, Department of Internal Medicine , The Jikei University School of Medicine , Tokyo , Japan.

Abstracts Background: Recent studies have identified the significance of proteinuria levels after initial induction therapies on the renal outcomes in patients with proliferative lupus nephritis, but the issue has not been evaluated in Japanese patients.

Methods: Based on the ISN/RPS classification, only patients diagnosed with lupus nephritis class III or IV were included. The remission of proteinuria 12 months after diagnosis, as well as the clinicopathological features at diagnosis, on renal outcomes was examined retrospectively. Read More

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http://dx.doi.org/10.1080/14397595.2018.1558948DOI Listing
December 2018

Fibrosis-4 index at diagnosis can predict all-cause mortality in patients with rheumatoid arthritis: a retrospective monocentric study.

Mod Rheumatol 2018 Dec 17:1-16. Epub 2018 Dec 17.

c Division of Rheumatology, Department of Internal Medicine , Yonsei University College of Medicine , Seoul , Republic of Korea.

Objectives Comorbidities and conventional risk factors influence the prognosis of patients with rheumatoid arthritis (RA). We investigated whether liver fibrosis burden is associated with all-cause mortality in patients with RA. Methods A total of 2812 patients with RA were retrospectively selected and reviewed. Read More

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http://dx.doi.org/10.1080/14397595.2018.1558760DOI Listing
December 2018
3 Reads

Long-term hip survival and factors influencing patient-reported outcomes after transtrochanteric anterior rotational osteotomy for osteonecrosis of the femoral head: A minimum 10-year follow-up case series.

Mod Rheumatol 2018 Dec 17:1-18. Epub 2018 Dec 17.

a Department of Orthopaedic Surgery, Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan.

Objectives: This retrospective study aimed to assess long-term hip survival after transtrochanteric anterior rotational osteotomy (ARO) for osteonecrosis of the femoral head (ONFH) and identify factors influencing patient-reported outcome measures (PROMs) in patients with preserved joints.

Methods: Altogether, 95 consecutive hips in 85 ONFH patients who underwent ARO during 2000-2007 (86.7% follow-up) were studied. Read More

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http://dx.doi.org/10.1080/14397595.2018.1558917DOI Listing
December 2018
1 Read

Long-Term Effectıveness and Safety of Canakınumab ın Pedıatrıc Famılıal Medıterranean fever patıents.

Mod Rheumatol 2018 Dec 17:1-13. Epub 2018 Dec 17.

b Department of Pediatric Rheumatology , Ümraniye Training and Research Hospital , Ümraniye/İstanbul , Turkey.

Background: Little is known about the long-term efficacy and safety of canakinumab in paediatric FMF patients.

Aim: To present the single centre experience of colchicine-resistant paediatric-onset FMF patients who were treated with canakinumab by off-label use since 2012.

Methods: The hospital files of 15 children who used canakinumab were retrospectively evaluated. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2018.1
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http://dx.doi.org/10.1080/14397595.2018.1559488DOI Listing
December 2018
4 Reads

Locomotive syndrome testing in young and middle adulthood.

Mod Rheumatol 2018 Dec 3:1-19. Epub 2018 Dec 3.

a Departments of Orthopaedic Surgery.

Background Previous epidemiological studies on locomotive syndrome (LS) have been mainly conducted in retired elderly people. However, from the view point of its prevention, it is important to assess currently-working younger people. The purpose of this study was to examine the status of the level of LS in young and middle-aged adult workers. Read More

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http://dx.doi.org/10.1080/14397595.2018.1551176DOI Listing
December 2018

IgG4-related kidney disease and retroperitoneal fibrosis: An update.

Mod Rheumatol 2018 Nov 30:1-24. Epub 2018 Nov 30.

c Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine , Fukuoka University , Fukuoka , Japan.

The most representative kidney lesion of IgG4-related disease (IgG4-RD) is plasma cell-rich tubulointerstitial nephritis (TIN) with distinctive imaging findings including multiple low-density lesions on contrast-enhanced computed tomography. In addition, membranous glomerulonephritis is a representative glomerular lesion of this disease. Recent advances have clarified that inflammation with IgG4-positive plasma cell infiltrates is not restricted to the renal parenchyma, but can be seen in outside the renal capsule, around medium-sized arteries such as lobar arteries, around nerves, and in the renal pelvis and periureter. Read More

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http://dx.doi.org/10.1080/14397595.2018.1554321DOI Listing
November 2018
12 Reads

Disease activity, treatment and long-term prognosis of adult juvenile idiopathic arthritis patients compared with rheumatoid arthritis patients.

Mod Rheumatol 2018 Nov 30:1-15. Epub 2018 Nov 30.

a Department of Lifetime Clinical Immunology , Graduate School of Medical and Dental Science, Tokyo Medical and Dental University (TMDU) , Tokyo , Japan.

Objective: To evaluate the difference between adult juvenile idiopathic arthritis (JIA, starting at <16 years) and rheumatoid arthritis (RA) .

Methods: Data on 128 adult JIA patients were from the National Database of Rheumatic Diseases in Japan (NinJa), 2014, divided into 4 groups by period of disease onset (Group 1: 2000-2013, n = 32; Group 2: 1981-1999, n = 32; Group 3: 1966-1980, n = 31; Group 4: ∼1965, n = 33). Disease activity, treatment and long-term prognosis of adult JIA patients was compared with RA patients matched for sex- and disease duration in each era. Read More

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http://dx.doi.org/10.1080/14397595.2018.1554228DOI Listing
November 2018
12 Reads

Efficacy and safety of tofacitinib in Japanese patients with rheumatoid arthritis by background methotrexate dose: a post-hoc analysis of clinical trial data.

Mod Rheumatol 2018 Nov 29:1-20. Epub 2018 Nov 29.

f The First Department of Internal Medicine , University of Occupational and Environmental Health , Kitakyushu , Japan.

Objectives: Tofacitinib is an oral JAK inhibitor for the treatment of rheumatoid arthritis (RA). We investigated concomitant methotrexate (MTX) dose on tofacitinib efficacy/safety in Japanese RA patients.

Methods: This post-hoc analysis pooled data from a 3-month Phase 2 study (NCT00603512) and a 24-month Phase 3 study (NCT00847613). Read More

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http://dx.doi.org/10.1080/14397595.2018.1553489DOI Listing
November 2018

Suppression of hematopoietic cell kinase ameliorates the bone destruction associated with inflammation.

Mod Rheumatol 2018 Nov 28:1-17. Epub 2018 Nov 28.

b Department of Cell Signaling, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan.

Objectives: To investigate the role of non-receptor tyrosine kinases (NRTKs) in inflammation-induced osteoclastogenesis.

Methods: Microarray analyses of global mRNA expression during receptor activator of NF-κB ligand (RANKL) and RANKL plus tumor necrosis factor (TNF)-α-induced osteoclast differentiation were performed. The inhibitory effect on TNF-α-induced osteoclast differentiation of A-419259, a potent inhibitor of hematopoietic cell kinase (Hck), was examined. Read More

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http://dx.doi.org/10.1080/14397595.2018.1553266DOI Listing
November 2018

Factors associated with discontinuation of glucocorticoids after starting biological disease-modifying antirheumatic drugs in rheumatoid arthritis patients.

Mod Rheumatol 2018 Nov 28:1-15. Epub 2018 Nov 28.

b Department of Allergy and Rheumatology, Graduate School of Medicine , The University of Tokyo , Tokyo , Japan.

Objectives: Glucocorticoids (GCs) are effective treatments for rheumatoid arthritis (RA) but long-term use has adverse effects. This study aimed to elucidate whether GCs can be discontinued by introducing bDMARDs (biological disease-modifying antirheumatic drugs) and the factors influencing the outcome.

Method: We included RA patients who had been orally taking GCs at the initiation of bDMARDs. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2018.1
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http://dx.doi.org/10.1080/14397595.2018.1553264DOI Listing
November 2018
9 Reads

KL-6 is a long-term disease-activity biomarker for interstitial lung disease associated with polymyositis/dermatomyositis, but is not a short-term disease-activity biomarker.

Mod Rheumatol 2018 Nov 28:1-20. Epub 2018 Nov 28.

a Institute of Rheumatology, Tokyo Women's Medical University , Tokyo , Japan.

Objectives: We aimed to evaluate the usefulness of serum KL-6 for interstitial lung disease (ILD) with polymyositis/dermatomyositis (PM/DM).

Methods: All consecutive and previously untreated adult patients with PM/DM who were admitted to our hospital from 2010 to 2015 were included. The associations between serum KL-6 levels and clinical information were retrospectively analyzed. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2018.1
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http://dx.doi.org/10.1080/14397595.2018.1553488DOI Listing
November 2018
7 Reads

Higher risk of hospitalized infection, cardiovascular disease, and fracture in patients with rheumatoid arthritis determined using the Japanese health insurance database.

Mod Rheumatol 2018 Nov 28:1-7. Epub 2018 Nov 28.

b Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Department of Rheumatology, School of Medicine , Tokyo Women's Medical University , Tokyo , Japan.

Objective: To evaluate the risk of hospitalized infection (HI), cardiovascular disease (CVD), stroke, and fracture in rheumatoid arthritis (RA) patients compared with non-RA patients using the Japanese health insurance database.

Method: Among individuals aged ≥18 years, RA cases were defined to have one RA diagnostic code and receiving ≥1 disease-modifying antirheumatic drug between 2005 and 2013 (n = 6,712). Age-, sex-, calendar year of the observation start-, and observation length-matched non-RA cases were selected at 1:5 (n = 33,560). Read More

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http://dx.doi.org/10.1080/14397595.2018.1519889DOI Listing
November 2018

The association between neck and shoulder discomfort-Katakori-and high somatizing tendency.

Mod Rheumatol 2018 Nov 28:1-14. Epub 2018 Nov 28.

b Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical & Research Center, Faculty of Medicine , the University of Tokyo , Tokyo , Japan.

Objectives: "Katakori", discomfort or dull pain around the neck and shoulder, is common in Japan. Somatizing tendency is important in the quality of daily living. This study aimed to examine the association between disability due to Katakori and high somatizing tendency. Read More

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http://dx.doi.org/10.1080/14397595.2018.1551177DOI Listing
November 2018
2 Reads

Clinical predictors of inadequate response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) including methotrexate (MTX) in untreated rheumatoid arthritis patients -A single-center observational study.

Mod Rheumatol 2018 Nov 28:1-18. Epub 2018 Nov 28.

b Department of Immunology and Rheumatology , Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , Japan.

Objectives: To investigate predictors of inadequate response to first conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) including methotrexate (MTX) in untreated rheumatoid arthritis (RA) patients in daily clinical practice.

Methods: Inadequate response to MTX or other csDMARDs was defined as being not low disease activity at 12 months in more than 3 of 4 composite measures, and discontinuation or start of biologic DMARDs. The association between baseline factors and csDMARDs-IR was assessed by univariate and multivariate logistic regression analyses. Read More

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http://dx.doi.org/10.1080/14397595.2018.1553265DOI Listing
November 2018

Comparison of recovery of mobility and self-efficacy after total knee arthroplasty based on two different protocols: A prospective cohort study.

Mod Rheumatol 2018 Nov 27:1-16. Epub 2018 Nov 27.

d Department of Orthopedic Surgery , Shiga University of Medical Science , Shiga , Japan.

Objectives; The purpose of this study was to compare the recovery of mobility and self-efficacy following total knee arthroplasty (TKA) between the 5-day and the 28-day protocol. This prospective cohort study was carried out at two hospitals. Methods; In total, 104 patients who underwent TKA were enrolled. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2018.1
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http://dx.doi.org/10.1080/14397595.2018.1553228DOI Listing
November 2018
14 Reads

Relationship between serum soluble receptor for advanced glycation end products (sRAGE) and disease activity in rheumatoid arthritis patients.

Mod Rheumatol 2018 Nov 24:1-17. Epub 2018 Nov 24.

a Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences , Tabriz , Iran .

Objective: Considering the important role of serum soluble receptor for advanced glycation end product (sRAGE/RAGE)-ligand system in rheumatoid arthritis (RA), this study aimed to evaluate serum sRAGE levels in RA patients compared to healthy subjects and to assess whether there is an association between sRAGE levels and disease characteristics in RA.

Methods: In this cross-sectional study, 60 RA patients according to the ACR/EULAR 2010 criteria and 30 age- and sex-matched healthy controls were included. In patients, clinical examination was performed and disease activity score 28 (DAS-28) measure of disease activity was assessed. Read More

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http://dx.doi.org/10.1080/14397595.2018.1551107DOI Listing
November 2018

IgG4-related respiratory disease.

Authors:
Shoko Matsui

Mod Rheumatol 2018 Nov 24:1-10. Epub 2018 Nov 24.

a Health Administration Center, University of Toyama , Toyama , Japan.

IgG4-related diseases (IgG4-RDs), such as autoimmune pancreatitis and IgG4-related Mikulicz disease, are often accompanied by intrathoracic lesions, which are called IgG4-related respiratory disease (IgG4-RRD). IgG4-RRD has few subjective symptoms, and is usually detected during workup of patients with extra-thoracic lesions of IgG4-RD. IgG4-RRD is characterized by various conditions, including masses, nodules, thickening, and infiltration at numerous sites in the thorax through lymphatic routes. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2018.1
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http://dx.doi.org/10.1080/14397595.2018.1548089DOI Listing
November 2018
4 Reads

Predictors of pre-sarcopenia in community-dwelling older adults: a 5-year longitudinal study.

Mod Rheumatol 2018 Nov 24:1-17. Epub 2018 Nov 24.

a Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine , Aichi , Japan.

Objectives: Sarcopenia is an aging-induced decrease in muscle mass that increases frailty and fall in elderly people. Pre-sarcopenia corresponds to the preliminary stage of sarcopenia. The purpose of this prospective study is to examine predictors of pre-sarcopenia in health screening. Read More

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http://dx.doi.org/10.1080/14397595.2018.1551171DOI Listing
November 2018
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IgG4-related periaortitis/periarteritis: an under-recognized condition that is potentially life-threatening.

Mod Rheumatol 2018 Nov 24:1-28. Epub 2018 Nov 24.

d Department of Cardiology , Osaka Medical College , Osaka , Japan.

Periaortitis and periarteritis are one of the clinical features of IgG4-related disease. Such vascular manifestations are reported to be present in 10%-30% of overall IgG4-related disease, and they may also appear as an isolated lesion of IgG4-related disease. As other types of large vessel vasculitis, IgG4-related vasculitis may cause significant clinical consequences. Read More

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http://dx.doi.org/10.1080/14397595.2018.1546367DOI Listing
November 2018

Risk Factors for Cytomegalovirus Disease with Cytomegalovirus Re-activation in Patients with Rheumatic Disease.

Mod Rheumatol 2018 Nov 24:1-12. Epub 2018 Nov 24.

a Inflammation and Immunology, Graduate School of Medical Science , Kyoto Prefectural University of Medicine , Kyoto , Japan.

Objective: To assess risk factors for cytomegalovirus (CMV) disease with CMV re-activation in patients with rheumatic disease.

Methods: The clinical data of consecutive patients with rheumatic disease who experienced CMV re-activation were examined. We evaluated the difference in various baseline factors at the first detection of CMV pp65 antigenemia on the development of CMV disease using logistic regression models. Read More

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http://dx.doi.org/10.1080/14397595.2018.1551264DOI Listing
November 2018
2 Reads

Less severe disease in patients with early systemic sclerosis?

Mod Rheumatol 2018 Nov 24:1-16. Epub 2018 Nov 24.

b Rheumatology Division, Escola Paulista de Medicina , Universidade Federal de São Paulo , São Paulo , Brazil.

Objectives: To evaluate the disease severity and activity in patients with a diagnosis of systemic sclerosis (SSc) after the 2013 ACR/EULAR classification criteria development compared to patients diagnosed before 2013.

Methods: One hundred and fifty-four subjects were included and assigned to the following groups: 120 SSc patients meeting the 1980 ACR criteria and with a diagnosis before 2013 (historical group), and 34 patients diagnosed after 2013, fulfilling the new ACR/EULAR criteria (early SSc group). Disease activity was assessed by the 2001 European Scleroderma Study Group Activity Index (EScSG-AI) and by the revised European Scleroderma Trials and Research group (EUSTAR) activity index. Read More

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http://dx.doi.org/10.1080/14397595.2018.1551265DOI Listing
November 2018
1 Read

Serum neopterin as well as ferritin, soluble interleukin-2 receptor, KL-6 and anti-MDA5 antibody titer provide markers of the response to therapy in patients with interstitial lung disease complicating anti-MDA5 antibody-positive dermatomyositis.

Mod Rheumatol 2018 Nov 19:1-7. Epub 2018 Nov 19.

a Division of Rheumatology, Department of Internal Medicine , Hyogo College of Medicine , Hyogo , Japan.

Objective: This study identified biomarkers that can be used to assess disease activity and response to therapy in patients with interstitial lung disease complicating anti-melanoma differentiation-associated gene 5 (MDA5) antibody (Ab)-positive clinically amyopathic dermatomyositis (CADM).

Methods: In 15 patients with interstitial lung disease complicating anti-MDA5 Ab-positive CADM, anti-MDA5 Ab, neopterin, interleukin (IL)-18, ferritin, and soluble interleukin 2 receptor (sIL-2R) levels were measured in cryopreserved serum specimens before and at multiple times after remission induction therapy, and their correlations were assessed.

Results: Anti-MDA5 Ab, neopterin, IL-18, ferritin, and sIL-2R levels did not differ significantly between patients who survived and those who succumbed to the disease. Read More

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http://dx.doi.org/10.1080/14397595.2018.1548918DOI Listing
November 2018
17 Reads

Pathophysiology of large vessel vasculitis and utility of interleukin-6 inhibition therapy.

Authors:
Hajime Yoshifuji

Mod Rheumatol 2018 Nov 14:1-7. Epub 2018 Nov 14.

a Department of Rheumatology and Clinical Immunology , Graduate School of Medicine, Kyoto University , Sakyo-ku , Kyoto , Japan.

Takayasu arteritis (TAK) and giant cell arteritis (GCA) affect mainly large- and medium-sized arteries. In refractory cases, vascular remodeling progresses and leads to serious outcomes. Studies have demonstrated that cytokines such as interleukin (IL)-6 play crucial roles in the pathophysiology of TAK and GCA. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2018.1
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http://dx.doi.org/10.1080/14397595.2018.1546358DOI Listing
November 2018
13 Reads

IL-6 inhibitor for the treatment of rheumatoid arthritis: A comprehensive review.

Mod Rheumatol 2018 Nov 14:1-29. Epub 2018 Nov 14.

c Graduate School of Information Science and Technology , Osaka University , Osaka , Japan.

Tocilizumab (TCZ) is an interleukin-6 (IL-6) inhibitor used for the treatment of rheumatoid arthritis (RA). It was developed in 2008, and its effectiveness is supported by evidence from all over the world based on its first decade of use. Although the overall efficacy and safety profiles of TCZ are similar to those of tumor necrosis factor (TNF) inhibitors, TCZ displays certain differences. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2018.1
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http://dx.doi.org/10.1080/14397595.2018.1546357DOI Listing
November 2018
24 Reads

Targeting Primary Sjögren's Syndrome.

Mod Rheumatol 2018 Nov 14:1-44. Epub 2018 Nov 14.

a Adeno-Associated Virus Biology Section , Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health , Bethesda , USA.

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease that is estimated to affect 35 million people worldwide. Hallmarks of the disease are a loss of salivary and lacrimal gland function as well as lymphocytic infiltration, elevated proinflammatory cytokines, and circulating autoantibodies. Patients often experience significant fatigue and a decrease in their quality of life. Read More

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http://dx.doi.org/10.1080/14397595.2018.1546268DOI Listing
November 2018
8 Reads

Validation of the Fibrosis-4 (FIB-4) index in the diagnosis of liver disease of rheumatoid arthritis patients treated with methotrexate.

Mod Rheumatol 2018 Oct 31:1-20. Epub 2018 Oct 31.

e Department of Gastroenterology , Fukushima Medical University , Fukushima , Japan.

Objectives To validate the usefulness of a hepatic fibrosis scoring system fibrosis-4 (FIB-4) index to diagnose liver diseases in rheumatoid arthritis (RA) patients treated with methotrexate (MTX). Methods The FIB-4 index (age(years) × AST(U/L)/platelet (PLT) (10/L) × √ALT(U/L)), proposed as a predictor for liver fibrosis in HIV/HCV coinfection, was evaluated in this study. RA patients on MTX treatment were screened by FIB-4 index values to detect fibrotic change in the liver. Read More

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http://dx.doi.org/10.1080/14397595.2018.1542962DOI Listing
October 2018

Interleukin 5-producing ST2 memory Th2 cells in IgG4-related dacryoadenitis and sialadenitis.

Mod Rheumatol 2018 Oct 25:1-5. Epub 2018 Oct 25.

a Department of Rheumatology and Clinical Immunology , School of Medicine, Sapporo Medical University , Hokkaido , Japan.

Objectives: Immunoglobulin (Ig) G4-related disease (IgG4-RD) is often complicated by allergic disorders. This study was conducted to investigate the mechanism of type 2 helper T-inflammation (Th2-inflammation) in IgG4-related dacryoadenitis and sialadenitis (IgG4-DS).

Methods: We separated and analyzed the proportion of growth stimulation expressed gene 2 (ST2) memory Th2 cells among the peripheral blood mononuclear cells by flow cytometry in cases with IgG4-DS and healthy individuals. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2018.1
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http://dx.doi.org/10.1080/14397595.2018.1526357DOI Listing
October 2018
20 Reads

Drug survival rates of biological disease-modifying antirheumatic drugs and Janus kinase-inhibitor therapy in 801 rheumatoid arthritis patients: a 14 year-retrospective study from a rheumatology clinic in Japan.

Mod Rheumatol 2018 Oct 18:1-19. Epub 2018 Oct 18.

a Kondo Clinic for Rheumatology and Orthopaedics , Fukuoka , Japan.

Objectives: To assess long-term outcomes for 7 biological disease-modifying antirheumatic drugs (bDMARDs) and one Janus kinase (JAK)-inhibitor in rheumatoid arthritis.

Methods: We retrospectively analyzed data from 801 rheumatoid arthritis patients visiting our rheumatology clinic between 2003 and 2017. We determined drug survival rates, drug discontinuation, and switching rates in these patients. Read More

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http://dx.doi.org/10.1080/14397595.2018.1537556DOI Listing
October 2018
5 Reads

Safety and efficacy of verinurad, a selective URAT1 inhibitor, for the treatment of patients with gout and/or asymptomatic hyperuricemia in the United States and Japan: Findings from two phase II trials.

Mod Rheumatol 2018 Dec 12:1-11. Epub 2018 Dec 12.

f Ardea Biosciences, Inc. , San Diego , CA , USA.

Objective: Evaluate efficacy/safety of verinurad monotherapy in patients with gout (Japan/US) or asymptomatic hyperuricemia (Japan).

Methods: Two randomized, placebo-controlled, phase II studies were conducted (NCT01927198/NCT02078219). Patients were randomized to once-daily doses of placebo or escalating doses of verinurad (study 1: 5-12. Read More

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http://dx.doi.org/10.1080/14397595.2018.1538003DOI Listing
December 2018
2 Reads

Association of hyperuricemia and pulmonary hypertension: A systematic review and meta-analysis.

Mod Rheumatol 2018 Oct 18:1-28. Epub 2018 Oct 18.

d Department of Rheumatology , Hanyang University Hospital for Rheumatic Diseases , Seoul , Republic of Korea.

Objectives: To investigate the association of hyperuricemia with pulmonary hypertension (PH) in term of subsequent development, severity, and prognosis of PH.

Methods: The authors systematically reviewed articles from databases and conducted meta-analyses as follows: (1) association of serum uric acid (UA) levels with the presence of PH; (2) association between serum UA levels and subsequent development of PH, in terms of odds ratio of the development of PH; and (3) association of serum UA levels with severity and prognosis of PH, in terms of pulmonary arterial pressure and hazard ratio of death.

Results: Twenty-six studies published between 1999 and 2017 were included. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2018.1
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http://dx.doi.org/10.1080/14397595.2018.1537555DOI Listing
October 2018
11 Reads
2.210 Impact Factor