177,980 results match your criteria Modern Rheumatology[Journal]
J Proteomics 2018 Dec 12. Epub 2018 Dec 12.
Proteomics Unit, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), 37007 Salamanca, Spain; Department of Medicine and General Cytometry Service-Nucleus, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), 37007 Salamanca, Spain. Electronic address:
Understanding the dynamic of the proteome is a critical challenge because it requires high sensitive methodologies in high-throughput formats in order to decipher its modifications and complexity. While molecular biology provides relevant information about cell physiology that may be reflected in post-translational changes, High-Throughput (HT) experimental proteomic techniques are essential to provide valuable functional information of the proteins, peptides and the interconnections between them. Hence, many methodological developments and innovations have been reported during the last decade. Read More
Chest 2018 Dec 12. Epub 2018 Dec 12.
Trauma, Critical Care and Surgery, Carolinas Medical Center, Charlotte, NC 28203.
Percutaneous dilatational tracheotomy (PDT) has become increasingly popular and gained widespread acceptance. The modern PDT procedure has also evolved to whereby it can be safely performed by surgeons and non-surgeons in the intensive care unit (ICU). Moreover, bedside PDT has proven clinical outcomes and can save hospital resources. Read More
J Appl Microbiol 2018 Dec 15. Epub 2018 Dec 15.
Jimei University, Xiamen, 361021, China.
Aims: The aim of this study was to determine the intestinal microflora of Anguilla marmorata at different growth rates and to identify potential probiotic/pernicious bacteria.
Methods And Results: Bacterial communities from 8 different fish intestinal sites (including the intestinal contents and the intestinal mucosa) from three fish groups (3 fast-, 2 medium-, and 3 stunted-growth samples), 2 water samples, and 1 diet sample were characterized by Illumina next-generation sequencing. The data revealed that the predominant genera (relative abundance of bacteria genera >1%) in the intestine of fast- and medium-growth groups were Cetobacterium, Edwardsiella, Clostridium, Lactococcus, Bacteroides, Plesiomonas, and Akkermansia. Read More
J Cell Physiol 2018 Dec 14. Epub 2018 Dec 14.
School of Medicine, Menzies Health Institute Queensland, Gold Coast, QLD.
The most important cause of developing hereditary breast cancer is germline mutations occurring in breast cancer (BCs) susceptibility genes, for example, BRCA1, BRCA2, TP53, CHEK2, PTEN, ATM, and PPM1D. Many BC susceptibility genes can be grouped into two classes, high- and low-penetrance genes, each of which interact with multiple genes and environmental factors. However, the penetrance of genes can also be represented by a spectrum, which ranges between high and low. Read More
Metab Brain Dis 2018 Dec 14. Epub 2018 Dec 14.
Department of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Consumption of high fat diet (HFD) is a health concern in modern societies, which participate in wide range of diseases. One underlying mechanism in the HFD mediated pathologies is disruption of insulin signaling activity. It is believed that HFD activates several stress signaling molecules such as MAPKs signaling pathway and these molecules participate in harmful effects in different cell populations including hippocampal cells. Read More
Knee Surg Sports Traumatol Arthrosc 2018 Dec 14. Epub 2018 Dec 14.
Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Purpose: Various implant materials have been used in medial, opening-wedge high tibial osteotomy (HTO) including traditional metal and modern polyetheretherketone (PEEK) implants. The purpose of this study was to compare metal and PEEK implants and determine safety, varus deformity correction, as well as short- to mid-term hardware removal and arthroplasty rates.
Methods: HTO performed with metal and PEEK implants were reviewed between 2000 and 2015 at two institutions with a minimum of 2 years follow-up. Read More
Sci Rep 2018 Dec 14;8(1):17843. Epub 2018 Dec 14.
Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences, The Laboratory of Melon Crops, Zhengzhou, Henan Province, 450009, China.
Fine mapping and discovery of candidate genes underlying seed size are important for modern watermelon breeding. Here, by using a high-resolution genetic map and whole-genome genetic variation detection aided by genome survey sequencing, we fine mapped and discovered candidate genes for seed size in watermelon. QTL (quantitative trait locus) mapping identified two pleiotropic QTLs for seed size, namely, qSS4 and qSS6, using a high-density genetic map constructed by specific length amplified fragment sequencing. Read More
Sci Rep 2018 Dec 14;8(1):17855. Epub 2018 Dec 14.
Department of Physics and Munich School of BioEngineering, Technical University of Munich, 85748, Garching, Germany.
Histological investigations are indispensable with regards to the identification of structural tissue details but are limited to two-dimensional images, which are often visualized in one and the same plane for comparison reasons. Nondestructive three-dimensional technologies such as X-ray micro- and nanoCT have proven to provide valuable benefits for the understanding of anatomical structures as they allow visualization of structural details in 3D and from arbitrary viewing angles. Nevertheless, low attenuation of soft tissue has hampered their application in the field of 3D virtual histology. Read More
Afr J Prim Health Care Fam Med 2018 Dec 11;10(1):1998. Epub 2018 Dec 11.
School of Health Science, University of Venda, South Africa; and, Population and Health Research Focus Area, Faculty of Human and Social Sciences, North-West University.
No abstract available. Read More
Arch Iran Med 2018 Nov 1;21(11):502-508. Epub 2018 Nov 1.
Pharmacology and Toxicology Department, Faculty of Pharmacy, October University for Modern Sciences and Arts, Egypt.
Background: The current study aimed to evaluate the mechanisms involved in protection against doxorubicin-induced cardiac and renal toxicities upon treatment with eicosapentaenoic acid and vitamin E.
Methods: Rats were randomly assigned to 4 groups: normal control, doxorubicin inducted control, eicosapentaenoic acid treated group and a final group pretreated with vitamin E. Lipid peroxidation, reduced glutathione (GSH) and tumor necrosis factor-alpha (TNF-α) contents as well as glutathione peroxidase (GPx), superoxide dismutase (SOD) and myeloperoxidase (MPO) activities were assessed. Read More
Sensors (Basel) 2018 Dec 13;18(12). Epub 2018 Dec 13.
Software and Information Systems Engineering, Ben Gurion University, Beer Sheva 84105, Israel.
Phenotyping is the task of measuring plant attributes for analyzing the current state of the plant. In agriculture, phenotyping can be used to make decisions concerning the management of crops, such as the watering policy, or whether to spray for a certain pest. Currently, large scale phenotyping in fields is typically done using manual labor, which is a costly, low throughput process. Read More
Toxins (Basel) 2018 Dec 13;10(12). Epub 2018 Dec 13.
Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.
Snakebite envenoming is a neglected tropical disease that each year claims the lives of 80,000⁻140,000 victims worldwide. The only effective treatment against envenoming involves intravenous administration of antivenoms that comprise antibodies that have been isolated from the plasma of immunized animals, typically horses. The drawbacks of such conventional horse-derived antivenoms include their propensity for causing allergenic adverse reactions due to their heterologous and foreign nature, an inability to effectively neutralize toxins in distal tissue, a low content of toxin-neutralizing antibodies, and a complex manufacturing process that is dependent on husbandry and procurement of snake venoms. Read More
Biomed Pharmacother 2019 Jan 5;109:969-984. Epub 2018 Nov 5.
Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Shihezi University, Shihezi, 832002, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, 710000, China. Electronic address:
Non-small cell lung cancer (NSCLC) has become one of the most general malignancies in the world and has been shown to be the leading cause of cancer-related deaths. Traditional Chinese medicine (TCM) is considered to be a useful medicine for survival, and has been used in Asia for thousands of years. Hedyotis diffusa Willd (HDW) is an important folk herb that is used in clinical treatment of various cancers in various Chinese medicine prescriptions. Read More
Biomed Pharmacother 2019 Jan 20;109:1680-1687. Epub 2018 Nov 20.
School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India. Electronic address:
The steady rise in life expectancy, modern life style and changing environmental conditions are responsible for increasing incidence of cancer. A number of chemical drugs have been used for cancer treatment; however the induction of genotoxic, carcinogenic and teratogenic effects limits their use. Alternatively, plant phytochemicals have been proven effective chemopreventive agents. Read More
Biomed Pharmacother 2019 Jan 6;109:1085-1099. Epub 2018 Nov 6.
State key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing, 211198, China. Electronic address:
Quercetin, a typical flavonoid, possesses diverse biochemical and physiological actions, including antiplatelet, estrogenic, and anti-inflammatory properties. This review mainly centers on recent ten years findings with respect to intervening diabetes and its complications with the well-known flavonoid quercetin. After a short introduction of quercetin, major in vitro and in vivo findings are summarized showing that quercetin is a promising molecule for the treatment of these diseases. Read More
Medizinhist J 2017 ;52(1):56-81
How was medicine-taught and studied in the early modern period? How did teachers and students relate to the tradition of medical texts? Historians have addressed these questions mainly through research on printed sources. This article uses student notes as a window on medical training in action in Montpellier. The student was Franqois Boissier de Sauvages; the teacher, Jacques Lazerme. Read More
Oper Neurosurg (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.
Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York.
J Hist Med Allied Sci 2018 Dec 14. Epub 2018 Dec 14.
Department of History, University of Rochester.
Gerald Grob's work in the history of psychiatry over the course of almost fifty years created a model for how historians might successfully situate mental health in its social and political context, and how inseparable it was from this context. Over the last twenty years, the field has grown tremendously. Historians have incorporated categories of analysis like gender and race, methodologies like cultural history and intellectual history, and sought to continue Grob's quest to understand American mental health history as a critical component of American history writ large. Read More
J Public Health (Oxf) 2018 Dec;40(suppl_2):ii42-ii51
Université de Montréal, CHU Sainte-Justine, Canada.
Background: In Burkina Faso, access to health services for women, children and people living with HIV/AIDS (PLWHAs) remains limited. Mobile telephony offers an alternative solution for reaching these individuals. The objective of the study was to improve equity of access to health care and information among women and PLWHAs by reinforcing community participation. Read More
Sci Total Environ 2018 Nov 28;657:420-434. Epub 2018 Nov 28.
Sustainable Agriculture Sciences Department, Rothamsted Research, North Wyke, Okehampton EX20 2SB, UK.
The Freshwater Pearl Mussel (Margaritifera margaritifera) is an endangered organism across its entire range. It has a complex life cycle and stringent habitat requirements and is therefore an indicator species for the general ecosystem health of host rivers. Whereas historical intensive pearl fishing contributed to population declines, excess nutrient and sediment loss associated with current land use pressures in host river catchments, including modern intensive farming practices, are now highlighted as primary contributory factors. Read More
PLoS One 2018 14;13(12):e0208932. Epub 2018 Dec 14.
National Center of Occupational Safety and Health, Minsk, Belarus.
Background: Exposure to metals via air sampling in workplace has been extensively studied; however, the magnitude of individual exposure in various occupational groups may vary dramatically. The aim of this cross-sectional study was to ascertain exposure to selected metals from metal fumes in a series of typical workplaces of contemporary tractor production.
Methods: Ninety-eight (median age 41 (interquartile range (IQR) 23) years, all men) workers from Minsk Tractor Plant were categorized into four groups, including assembly shop workers (group 1); thermal shop staff (group 2); steelmakers (group 3) and welders (group 4). Read More
Hist Psychol 2018 Dec 13. Epub 2018 Dec 13.
A common view among ancient historians about Roman attentiveness to children's psychological development needs reconsideration. The view holds that Romans ignored children's cognitive ontogeny, perceiving early childhood as a largely undifferentiated life stage. A separate but related issue is the problematic claim that Roman childhood was entirely a matter of social construction. Read More
Vopr Virusol 2018 ;63(5):202-211
National Research Center for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Moscow, 123098, Russian Federation.
Modern chemotherapy of cytomegalovirus (CMV) infections has a very limited arsenal of first-line drugs. These are preparations of ganciclovir (GCV) belonging to the class of modified nucleosides and its metabolic precursor ganciclovir valine ester. After three-step phosphorylation, GCV, as a structural analogue of the natural nucleotide, competes with it for binding to DNA polymerase and, due to its structural features, inhibits its activity. Read More
Isr Med Assoc J 2018 Dec;20(12):770-772
Department of Internal Medicine F, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Background: Erythema nodosum (EN) is the most common type of panniculitis, commonly secondary to infectious diseases.
Objectives: To elucidate the causative factors and the clinical presentation of patients with EN (2004-2014) and to compare their data to those reported in a previous study.
Methods: A retrospective study was conducted of all patients diagnosed with EN who were hospitalized at Soroka University Medical Center (2004-2014). Read More
Glob Chang Biol 2019 Jan 22;25(1):155-173. Epub 2018 Nov 22.
Institute of Crop Science and Resource Conservation INRES, University of Bonn, Bonn, Germany.
Wheat grain protein concentration is an important determinant of wheat quality for human nutrition that is often overlooked in efforts to improve crop production. We tested and applied a 32-multi-model ensemble to simulate global wheat yield and quality in a changing climate. Potential benefits of elevated atmospheric CO concentration by 2050 on global wheat grain and protein yield are likely to be negated by impacts from rising temperature and changes in rainfall, but with considerable disparities between regions. Read More
J Comput Chem 2018 Dec 14. Epub 2018 Dec 14.
Max-Planck-Institut für Kohlenforschung, 45470, Mülheim an der Ruhr, Germany.
Most modern semiempirical quantum-chemical (SQC) methods are based on the neglect of diatomic differential overlap (NDDO) approximation to ab initio molecular integrals. Here, we check the validity of this approximation by computing all relevant integrals for 32 typical organic molecules using Gaussian-type orbitals and various basis sets (from valence-only minimal to all-electron triple-ζ basis sets) covering in total more than 15.6 million one-electron (1-e) and 10. Read More
Small 2018 Dec 13:e1804661. Epub 2018 Dec 13.
State Key Laboratory for Chemo/Biosensing and Chemometrics, School of Physics and Technology, Wuhan University, Wuhan, 430072, China.
Photoinduced memory devices with fast program/erase operations are crucial for modern communication technology, especially for high-throughput data storage and transfer. Although some photoinduced memories based on 2D materials have already demonstrated desirable performance, the program/erase speed is still limited to hundreds of micro-seconds. A high-speed photoinduced memory based on MoS /single-walled carbon nanotubes (SWCNTs) network mixed-dimensional van der Waals heterostructure is demonstrated here. Read More
Adv Mater 2018 Dec 13:e1805106. Epub 2018 Dec 13.
Centre for Optical and Electromagnetic Research, State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou, 310058, China.
Illusion devices are usually designed using transformation optics. Here, a new method is proposed to achieve optical illusions without external devices by elaborately manipulating the scattering potential of an object. In contrast to the conventional transformation optics method, which completely replaces one object by the image of another object using complementary\restoring media and a superlens, the method described here is more of a cosmetic operation for an object, which modifies the scattering pattern of the object to mimic another object by exchanging their scattering potentials in two symmetrical areas in the wave vector domain. Read More
Mol Genet Genomic Med 2018 Dec 12. Epub 2018 Dec 12.
The 2nd Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Background: Osteonecrosis of the femoral head (ONFH) is a refractory disease which frequently occurs in young and middle-aged people. Recent studies indicated that MMP-14 played an important role in the development of chondrocytes, metabolism of osteoblasts as well as fate decision of hypertrophic chondrocytes. The aim of this study was to investigate the association between polymorphisms of MMP-14 and steroid-induced osteonecrosis of the femoral head in the Chinese population. Read More
J Cell Physiol 2018 Dec 12. Epub 2018 Dec 12.
Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia, Malaysia.
Serum high-sensitivity C-reactive protein (hs-CRP) is predictive of coronary artery disease (CAD). The aim of this study was to examine the possible association of hs-CRP with presence and severity of CAD and traditional CAD risk factors. This case-control study was carried out on 2,346 individuals from September 2011 to May 2013. Read More
Small 2018 Dec 12:e1803939. Epub 2018 Dec 12.
The Department of Chemical Engineering, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.
A flexible and stretchable field-effect transistor (FET) is an essential element in a number of modern electronics. To realize the potential of this device in harsh real-world conditions and to extend its application spectrum, new functionalities are needed to be introduced into the device. Here, solution-processable elements based on carbon nanotubes that empower flexible and stretchable FET with high hole-mobility (µ ≈ 10 cm V s ) and relatively low operating voltages (<8 V) and that retain self-healing properties of all FET components are reported. Read More
Obes Rev 2018 Dec 11. Epub 2018 Dec 11.
Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL, USA.
The rapid decrease in infectious diseases globally has coincided with an increase in the prevalence of obesity and other components of metabolic syndrome. Insulin resistance is a common feature of metabolic syndrome and can be influenced by genetic and non-genetic/environmental factors. The emergence of metabolic syndrome epidemics over only a few decades suggests a more prominent role of the latter. Read More
Anat Sci Educ 2018 Dec 11. Epub 2018 Dec 11.
Centre for Learning Anatomical Sciences, University of Southampton, Southampton, United Kingdom.
Anatomy, has in history, been linked to helpful ways to remember structures, branches of nerves, structures passing through foramina et cetera. Scalp is even a mnemonic in itself (Skin, Connective tissue, Aponeurosis, Loose areolar tissue, Pericranium). There has been concern by some educators that using mnemonics or rhymes promotes a surface approach to learning and is unhelpful in establishing long term and meaningful deep learning. Read More
IUBMB Life 2018 Dec 11. Epub 2018 Dec 11.
Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD.
For many decades, kinases have predominantly been characterized as oncogenes and drivers of tumorigenesis, because activating mutations in kinases occur in cancer with high frequency. The oncogenic functions of kinases relate to their roles as growth factor receptors and as critical mediators of mitogen-activated pathways. Indeed, some of the most promising cancer therapeutic agents are kinase inhibitors. Read More
Chem Soc Rev 2018 Dec 14. Epub 2018 Dec 14.
Manufacturing Business Unit, Commonwealth Scientific and Industrial Research Organisation, Bayview Avenue, Clayton, VIC 3168, Australia.
Zwitterionic polymers, including polyampholytes and polybetaines, are polymers with both positive and negative charges incorporated into their structure. They are a unique class of smart materials with great potential in a broad range of applications in nanotechnology, biomaterials science, nanomedicine and healthcare, as additives for bulk construction materials and crude oil, and in water remediation. In this Tutorial Review, we aim to highlight their structural diversity and design criteria, and their preparation using modern techniques. Read More
Opt Lett 2018 Dec;43(24):5985-5988
The nonlinear Schrödinger equation (NLSE) is often used as a master path-average model for fiber-optic transmission lines. In general, the NLSE describes the co-existence of dispersive waves and soliton pulses. The propagation of a signal in such a nonlinear channel is conceptually different from linear systems. Read More
Opt Lett 2018 Dec;43(24):5905-5908
Controlling light polarization is one of the most essential routines in modern optical technology. Since the demonstration of optical pulse shaping by spatial light modulators and its potential in controlling the quantum reaction pathways, it paved the way for many applications as a coherent control of the photoionization process or as polarization shaping of terahertz (THz) pulses. Here, we evidenced efficient nonresonant and noncollinear χ-type light-matter interaction in femtosecond polarization-sensitive time-resolved optical measurements. Read More
Ugeskr Laeger 2018 Dec;180(50)
In 1492 Johannes de Ketham published the urine wheel which was thought to reveal imbalances of the four humours according to the colour of the urine. The urine wheel presented in this article is a foldable modern version linking the colours of urine to different diseases, food and drugs. Read More
BMC Vet Res 2018 Dec 14;14(1):400. Epub 2018 Dec 14.
College of Veterinary Medicine, Hebei Agricultural University, Baoding, 071001, Hebei, China.
Background: Since July in 2015, an emerging infectious disease, Fowl adenovirus (FAdV) species C infection with Hepatitis-Hydropericardium syndrome was prevalent in chicken flocks in China. In our study, one FAdV strain was isolated from commercial broiler chickens and was designated as SDSX1.The phylogenetic information, genetic mutations and pathogenicity of SDSX1 were evaluated. Read More
J Cardiol Cases 2016 Jul 9;14(1):29-31. Epub 2016 Apr 9.
James Cook University Hospital, Middlesbrough, UK.
Techniques to overcome challenging venous anatomy have become an increasingly important part of modern day cardiac device implantation. Complete superior vena cava (SVC) obstruction, however, is a rare and serious clinical entity, and consequently there is limited clinical experience in addressing this pathology in the context of transvenous pacemaker implantation. We present the case of a 48-year-old renal transplant patient with sick sinus syndrome and recurrent syncope, who had an upper SVC occlusion and a failed epicardial pacing system. Read More
J Cardiol Cases 2016 Jul 29;14(1):17-20. Epub 2016 Apr 29.
Department of Cardiovascular Sciences, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Postcardiac injury syndrome (PCIS) is characterized by the appearance of pericardial, pleural, or pulmonary parenchymal inflammation following a cardiac operation. The autoimmune disorder is characterized by eosinophilia, pleuritic chest pain, pleural, and pericardial effusion. It is a troublesome complication, which may prolong hospital stay and lead to severe and life-threatening conditions. Read More
J Cardiol Cases 2015 May 27;11(5):139-141. Epub 2015 Feb 27.
Department of Cardiology, Dhaka Medical College, Dhaka, Bangladesh.
Atypical presentations of common diseases are often difficult to identify in time, nonetheless necessary, especially in cases of diseases like ischemic heart disease (IHD) which otherwise may progress into irreversible stage and ultimately, fatality, in the absence of timely administered medical treatment. We report a case of a 51-year-old male, presenting initially with only headache as the sole symptom, who later was diagnosed with severe coronary artery disease, and the symptoms resolved completely after coronary angioplasty with stenting. < Atypical presentations, such as headache, can be more prevalent in ischemic heart disease (IHD) than was thought of, so awareness of the possibility of IHD while assessing headache and further study to see actually how commonly headache is associated with IHD are necessary. Read More
J Health Pollut 2017 Jun 22;7(14):37-47. Epub 2017 Jun 22.
Research Desk Consulting Ltd., Kwabenya-Accra, Ghana.
Background: Municipal solid wastes management has recently become an important public health concern. Municipal solid wastes are a major source of raw materials that could be used for resource recovery for diverse applications.
Objectives: The present study aimed to determine the composition of municipal solid waste and recoverable resources from the waste of the Ga East Municipal Assembly (GEMA) in the Greater Accra region of Ghana. Read More
J Cardiol Cases 2015 Sep 6;12(3):74-78. Epub 2015 Jun 6.
Division of Cardiology, Saiseikai Kumamoto Hospital, Cardiovascular Center, Kumamoto, Japan.
We present two cases of spontaneous coronary artery dissection (SCAD), which were diagnosed and treated with emergent percutaneous coronary intervention (PCI). Patients with ongoing ischemia due to SCAD need emergent coronary revascularization with PCI or coronary artery bypass grafting. We discuss the difficulties of PCI to bail out unstable SCAD regardless of the modern techniques and modalities. Read More
Struct Equ Modeling 2017 8;24(4):626-635. Epub 2017 Feb 8.
The current widespread availability of software packages with estimation features for testing structural equation models with binary indicators makes it possible to investigate many hypotheses about differences in proportions over time that are typically only tested with conventional categorical data analyses for matched pairs or repeated measures, such as McNemar's chi-squared. The connection between these conventional tests and simple longitudinal structural equation models is described. The equivalence of several conventional analyses and structural equation models reveals some foundational concepts underlying common longitudinal modeling strategies and brings to light a number of possible modeling extensions that will allow investigators to pursue more complex research questions involving multiple repeated proportion contrasts, mixed between-subjects × within-subjects interactions, and comparisons of estimated membership proportions using latent class factors with multiple indicators. Read More
Sante Publique 2018 Sep;S2(HS2):145-156
Introduction: Health literacy refers to the competences and resources required by individuals to meet the complex demands of health in modern society. This paper describes and analyses the health literacy profiles of type 2 diabetic patients included in a 2-year long self-management education programme.
Methods: Nested in the ERMIES randomized controlled trial conducted in Reunion island, the ERMIES Ethnosocio study explored health literacy by means of two complementary approaches: description of health literacy profiles via the French version of the multidimensional ?Health Literacy Questionnaire?, and a socio-anthropological perspective based on 40 semi-structured interviews carried out in 2012 and then in 2015. Read More
Methods Mol Biol 2019 ;1894:171-180
State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China.
Mitochondria are organelles that play a key role in the regulation of cell energy metabolism, biosynthesis, and cell death. Mitochondria are also involved in important physiological processes, such as the three-carboxylic acid cycle, the oxidation of fatty acids and amino acids, and calcium ion homeostasis. The energy demands of male germ cells during mitosis and meiosis are higher than those of somatic cells, suggesting that mitochondria play a critical role in sperm. Read More
Methods Mol Biol 2019 ;1883:235-249
Data Mining and Modelling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium.
Recent technological breakthroughs in single-cell RNA sequencing are revolutionizing modern experimental design in biology. The increasing size of the single-cell expression data from which networks can be inferred allows identifying more complex, non-linear dependencies between genes. Moreover, the inter-cellular variability that is observed in single-cell expression data can be used to infer not only one global network representing all the cells, but also numerous regulatory networks that are more specific to certain conditions. Read More
Methods Mol Biol 2019 ;1883:111-142
Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand.
Biological networks are a very convenient modeling and visualization tool to discover knowledge from modern high-throughput genomics and post-genomics data sets. Indeed, biological entities are not isolated but are components of complex multilevel systems. We go one step further and advocate for the consideration of causal representations of the interactions in living systems. Read More
Orig Life Evol Biosph 2018 Dec 13. Epub 2018 Dec 13.
Department of Bioinorganic Chemistry and Chemical Evolution, Institute of Chemistry, University of Hohenheim, Garbenstr. 30, 70599, Stuttgart, Germany.
In previous experiments that simulated conditions on primordial volcanic islands, we demonstrated the abiotic formation of hydrophobic porphyrins. The present study focused on the question whether such porphyrins can be metalated by prebiotically plausible metal ion sources. We used water-insoluble octaethylporphyrin (Hoep) as a model compound. Read More