336,995 results match your criteria Mixed Connective Tissue Disease


Disentangling the effects of disturbance, climate and tree age on xylem hydraulic conductivity of Betula pendula.

Ann Bot 2018 Dec 14. Epub 2018 Dec 14.

Department of Physical Geography and Geoecology, Faculty of Science, Charles University, Prague, Czech Republic.

Background And Aims: The increasing frequency of disturbances in temperate forests is responsible for the greater numbers of trees with mechanically damaged cambial zones. Adjustment of wood anatomical structure to balance between safe and efficient water conductivity is one mechanism trees employ to cope with mechanical damage. The relative role of disturbances, tree age and climate in shaping xylem conduits and affecting xylem hydraulic conductivity remains unknown. Read More

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December 2018

Can mHealth improve timeliness and quality of health data collected and used by health extension workers in rural Southern Ethiopia?

J Public Health (Oxf) 2018 Dec;40(suppl_2):ii74-ii86

REACH Ethiopia, Hawassa, Ethiopia.

Background: Health extension workers (HEWs) are the key cadre within the Ethiopian Health Extension Programme extending health care to rural communities. National policy guidance supports the use of mHealth to improve data quality and use. We report on a mobile Health Management Information system (HMIS) with HEWs and assess its impact on data use, community health service provision and HEWs' experiences. Read More

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December 2018

National survey: Developing a common approach to grading of practice in pre-registration midwifery.

Nurse Educ Pract 2018 Nov 26;34:150-160. Epub 2018 Nov 26.

University College London, Gower St, Bloomsbury, London, WC1E 6BT, United Kingdom. Electronic address:

This paper presents the final phase of a national project exploring grading of practice in programmes leading to registration as a midwife in the United Kingdom. The aim was to develop a generic framework for grading practice, enhancing standardisation while enabling flexibility in application of current and new educational standards. A mixed method on-line survey considered existing practice assessment tools, factors contributing to robust and reliable assessment and perceptions of two assessment tools developed by the research team: a 'Lexicon Framework' and 'Rubric', which were tested through scenarios. Read More

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November 2018

Repetitive negative thinking as a mediator in prospective cross-disorder associations between anxiety and depression disorders and their symptoms.

J Behav Ther Exp Psychiatry 2018 Nov 29;63:6-11. Epub 2018 Nov 29.

VU University Medical Center, Department of Psychiatry, Amsterdam, the Netherlands.

Background And Objectives: Comorbidity among anxiety and depression disorders and their symptoms is high. Rumination and worry have been found to mediate prospective cross-disorder relations between anxiety and depression disorders and their symptoms in adolescents and adults. We examined whether generic repetitive negative thinking (RNT), that is content- and disorder-independent, also mediates prospective cross-disorder associations between anxiety and depressions disorders and their symptoms. Read More

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November 2018
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Attentional bias modification reduces clinical depression and enhances attention toward happiness.

J Psychiatr Res 2018 Dec 1;109:145-155. Epub 2018 Dec 1.

Department of Psychology, The Third Military Medical University, Chongqing, 400038, China.

Difficulty in clinical antidepressant treatment leads to the pursuit of alternative treatments, such as cognitive-behavior therapy (CBT). CBT combined with regular antidepressants have indicated an optimal therapeutic effect in clinic. Attentional bias is important in the occurrence and remission of depression, however, few studies have explored the effect of attentional bias modification (ABM) on depression, and inconsistent results have been obtained due to the heterogeneity in the targeted populations, training tasks, strategies, and materials. Read More

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December 2018

4-Fluoramphetamine in the Netherlands: Text-mining and sentiment analysis of internet forums.

Int J Drug Policy 2018 Dec 11;64:34-39. Epub 2018 Dec 11.

Trimbos Institute, The Netherlands Institute of Mental Health and Addiction, Da Costakade 45, 3521VS, Utrecht, the Netherlands.

Background: Users of new psychoactive substances including 4-fluoroamphetamine (4-FA/4-FMP) frequently share their experiences or opinions in online drug forums. We have tested the potential of computerised analysis of drug users' forum posts for monitoring and early detection of trends. Specifically, we tested whether changes in the volume of 4-FA related posts and sentiments expressed in those posts can be observed around the time 4-FA was increasingly reported by Dutch drug monitoring sources (2012-2017). Read More

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December 2018

Enhanced DGT capability for measurements of multiple types of analytes using synergistic effects among different binding agents.

Sci Total Environ 2018 Dec 4;657:446-456. Epub 2018 Dec 4.

State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, China.

There is a requirement for simultaneous measurements of diverse analytes to reveal their biogeochemical couplings in the environment. In this study, we first realized simultaneous measurements of three types of analytes, including sulfide [S(-II)], metallic cations, and oxyanions by diffusive gradients in thin films (DGT) using a new mixed ZrO-CA binding gel. The ZrO-CA gel exhibited faster absorption rates for oxyanions than previously reported ZrO-Chelex gel, and faster absorption rates for cations when the gel was saturated with S(-II). Read More

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December 2018

Perceptions of climate change and occupational heat stress risks and adaptation strategies of mining workers in Ghana.

Sci Total Environ 2018 Dec 5;657:365-378. Epub 2018 Dec 5.

Edith Cowan University, Perth, Western Australia, Australia; Ghana Institute of Management and Public Administration, Ghana. Electronic address:

Heavy physical workload for long hours coupled with increasing workplace heat exposure due to rising temperatures stemming from climate change, especially where there are inadequate prevention and control policies, adversely affect workers' health and safety, productive capacity and social well-being. However, variations in workers' concerns and awareness of occupational heat stress and climate change risks impede the effectiveness of heat stress management. A mixed method approach was used to assess climate change perceptions and occupational heat stress risks and adaptation strategies of Ghanaian mining workers. Read More

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December 2018

Exploring the underpinning mechanisms of the proximity effect within a competitive food environment.

Appetite 2018 Dec 11. Epub 2018 Dec 11.

Department of Psychology, School of Social Sciences, Birmingham City University, Curzon Building, 4 Cardigan Street, Birmingham, B4 7BD, United Kingdom.

Objective: One method of influencing an individual's food consumption involves placing unhealthy snacks further away from individuals, known as the "proximity effect". However, only one laboratory study has explored the effect while both an unhealthy and a healthy option are presented simultaneously. Further, little is known about the potential underpinning mechanisms of the effect. Read More

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December 2018

Melatonin inhibits MLL-rearranged leukemia via RBFOX3/hTERT and NF-κB/COX-2 signaling pathways.

Cancer Lett 2018 Dec 10. Epub 2018 Dec 10.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China; State Key Laboratory of Targeted Drug for Tumors of Guangdong Province, Guangzhou Double Bioproduct Inc., Guangzhou, China. Electronic address:

MLL-rearranged leukemia is an aggressive malignancy associated with poor outcome, which is refractory to conventional treatment. Melatonin has been proven to exert anti-tumor activity, but the effect of melatonin on MLL-r leukemia and the underlying mechanism remain poorly understood. In this study, melatonin inhibited cell proliferation and induced apoptosis by activating the caspase-dependent apoptotic pathway in MLL-r leukemia cells. Read More

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December 2018

Relationships between Financial Toxicity and Symptom Burden in Cancer Survivors: A Systematic Review.

J Pain Symptom Manage 2018 Dec 11. Epub 2018 Dec 11.

School of Nursing, Queensland University of Technology, Kelvin Grove, Q4059, Australia; Department of Physiological Nursing, University of California, San Francisco, 2 Koret Way - N631Y, San Francisco, CA 94143-0610.

Context: Financial toxicity (FT) is used to describe the financial distress/hardship associated with cancer and its treatment.

Objectives: The aim of this review was to explore the relationship between FT and symptom burden.

Method: A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Read More

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December 2018
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Black and Minority Ethnic women's decision-making for risk reduction strategies after BRCA testing: Use of context and knowledge.

Eur J Med Genet 2018 Dec 11. Epub 2018 Dec 11.

King's College London, Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, London, United Kingdom; Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, United Kingdom.

Within the field of breast cancer care, women concerned about their family history are offered genetic testing and subsequent treatment options based on several factors which include but are not limited to personal and family cancer disease histories and clinical guidelines. Discussions around decision-making in genetics in Black and Minority Ethnic (BME) groups are rarely documented in literature, and information regarding interactions with genetics services is usually discussed and linked to lack of scientific knowledge. As such, counselling sessions based only on scientific and medical information miss out the many reasons participants consider in making health decisions, information which can be used to encourage BME women to engage in cancer genetics services. Read More

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December 2018
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A ball milling-based one-step transformation of chitin biomass to organo-dispersible strong nanofibers passing highly time and energy consuming processes.

Int J Biol Macromol 2018 Dec 11. Epub 2018 Dec 11.

Research Center for Bio-based Chemistry, Korea Research Institute of Chemical Technology (KRICT), Ulsan 44429, Republic of Korea; Advanced Materials and Chemical Engineering, University of Science and Technology (UST), Daejeon 34113, Republic of Korea. Electronic address:

Chitin, a sustainable and functional biological macromolecule, can be converted into chitin nanofibers (ChNFs), and are applicable as a mechanically reinforcing and bioactive filler for polymer matrices. Improving the performance of ChNFs typically relies on their nanofibrilization and miscibility with matrices. To transform chitin biomass into organo-dispersible ChNFs, a series of time-/energy-consuming chemical and mechanical treatments are required: 1) deacetylation, 2) disintegration, 3) surface modification to minimize their aggregation through hydrogen bonds, 4) drying, and 5) re-dispersion. Read More

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December 2018
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Is ventromedial prefrontal cortex critical for behavior change without external reinforcement?

Neuropsychologia 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurobiology, The Faculty of Life Sciences, Tel Aviv University; Sagol School of Neuroscience, Tel Aviv University, Israel.

Cue-approach training (CAT) is a novel paradigm that has been shown to induce preference changes towards items without external reinforcements. In the task, the mere association of a neutral cue and a speeded button response has been shown to induce a behavioral choice preference change lasting for months. This paradigm includes several phases: after the training of individual items, behavior change is manifested in binary choices of items with similar initial values. Read More

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December 2018

NOP agonist action of cebranopadol counteracts its liability to promote physical dependence.

Peptides 2018 Dec 11. Epub 2018 Dec 11.

Department of Medical Sciences, Section of Pharmacology, and National Institute of Neuroscience, University of Ferrara, Ferrara, Italy. Electronic address:

Cebranopadol is a mixed NOP/opioid receptor agonist currently under development as innovative analgesic. In this study the liability of cebranopadol to produce opioid-type physical dependence has been evaluated in comparison with morphine in wild type mice and in mice knockout for the NOP receptor gene (NOP(-/-)). Mice were treated twice a day for 5 days with increasing doses of cebranopadol or morphine (cumulative doses 10. Read More

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December 2018
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Impact of material properties and process variables on the residence time distribution in twin screw feeding equipment.

Int J Pharm 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.

Screw feeders are integrated as dispensing units in most continuous manufacturing platforms. Hence, characterizing and modelling the residence time distribution (RTD) of materials in feeders is indispensable to understand the traceability of raw materials from the drum till tablet, enabling the separation of non-confirming material. The proposed methodology addressed this leap in knowledge by characterizing materials, performing RTD trials according to an experimental design, applying RTD models and establishing a partial least square (PLS) regression model that links the material properties and process variables with the RTD responses as outputs. Read More

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December 2018

Interaction of Phthorimaea operculella granulovirus with a Nosema sp. microsporidium in larvae of Phthorimaea operculella.

J Invertebr Pathol 2018 Dec 11. Epub 2018 Dec 11.

Institute for Biological Control, Federal Research Centre for Cultivated Plants, Julius Kühn Institute, Heinrichstraße 243, 64287 Darmstadt, Germany. Electronic address:

An antagonistic effect of a microsporidium (Nosema sp.) infection on the virulence of Phthorimaea operculella granulovirus (PhopGV) was recorded in potato tuber moth (Phthorimaea operculella) larvae with mixed infections. When the P. Read More

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December 2018

Counterfactual Thinking, Causation, and Covariation in Mock Juror Assessments of Negligence: Twenty-Five Years Later.

Authors:
Jason A Cantone

Psychol Rep 2018 Dec 14:33294118816945. Epub 2018 Dec 14.

George Mason University, Fairfax, VA, USA.

In the past three decades, researchers have examined counterfactual thinking and causation in decision making. However, little work has applied these findings to trial settings. The present research examined two conflicting theories regarding counterfactual thinking and causation to elaborate on earlier work examining counterfactual thinking in negligence law cases. Read More

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December 2018

Identifying notions of environment in obesity research using a mixed-methods approach.

Obes Rev 2018 Dec 14. Epub 2018 Dec 14.

Copenhagen Centre for Health Research in the Humanities, The Saxo Institute, University of Copenhagen, Copenhagen, Denmark.

The recent rise of computation-based methods in social science has opened new opportunities for exploring qualitative questions through analysis of large amounts of text. This article uses a mixed-methods design that incorporates machine reading, network analysis, semantic analysis, and qualitative analysis of 414 highly cited publications on obesogenic environments between 2001 and 2015. The method produces an elaborate network map exhibiting five distinct notions of environment, all of which are currently active in the field of obesity research. Read More

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December 2018
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Optogenetic control of iPS cell-derived neurons in 2D and 3D culture systems using channelrhodopsin-2 expressed by the SYN1 and CaMKII promoters.

J Tissue Eng Regen Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Oncology, Old Road Campus Research Building, University of Oxford, UK.

Development of optogenetically controllable human neural network model in three-dimensional (3D) can provide an investigative system that is physiologically relevant or mimic to the human brain. Light-sensitive neurons were generated by transducing channelrhodopsin-2 (ChR2) into human induced pluripotent stem cells (hiPSCs) derived neural progenitor cells (Axol) using lentiviruses and cell-type specific promoters. A mixed population of human iPSC-derived cortical neurons, astrocytes and progenitor cells was obtained (Axol-ChR2) upon neural differentiation. Read More

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December 2018

Associations of Patient Experience in Primary Care With Hospitalizations and Emergency Department Visits on Isolated Islands: A Prospective Cohort Study.

J Rural Health 2018 Dec 14. Epub 2018 Dec 14.

Department of Family and Community Medicine, Hamamatsu University School of Medicine, Higashi-ku, Hamamatsu, Shizuoka, Japan.

Purpose: In rural areas, the management of hospitalizations and emergency department (ED) visits is an important issue, and it is compounded by factors such as the long distance to secondary care facilities, funding difficulties in many rural medical institutions, and shortage of medical staff. While better patient experience (PX) has been shown to reduce hospitalizations and ED visits, previous studies have not considered the differences between urban and rural areas. In addressing this gap, this study examines the association between PX and hospitalizations/ED visits on isolated islands. Read More

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December 2018

Ethnic background and children's television viewing trajectories: The Generation R Study.

PLoS One 2018 14;13(12):e0209375. Epub 2018 Dec 14.

Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands.

This study, conducted in the Netherlands, evaluated the association between ethnic background and children's TV viewing time at multiple time points and its trajectory. We analyzed 4,833 children with a Dutch, Moroccan, Turkish, or Surinamese ethnic background from the Generation R Study, a population-based study in the Netherlands. Parent-reported television viewing time for children at ages 2, 3, 4, 6, and 9 years was collected by questionnaires sent from April 2004 until January 2015. Read More

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December 2018

Multiscale computational model of Achilles tendon wound healing: Untangling the effects of repair and loading.

PLoS Comput Biol 2018 Dec 14;14(12):e1006652. Epub 2018 Dec 14.

Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States of America.

Mechanical stimulation of the healing tendon is thought to regulate scar anisotropy and strength and is relatively easy to modulate through physical therapy. However, in vivo studies of various loading protocols in animal models have produced mixed results. To integrate and better understand the available data, we developed a multiscale model of rat Achilles tendon healing that incorporates the effect of changes in the mechanical environment on fibroblast behavior, collagen deposition, and scar formation. Read More

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December 2018

Predictors of malaria Rapid Diagnostic Tests' utilisation among healthcare workers in Zamfara State.

PLoS One 2018 14;13(12):e0200856. Epub 2018 Dec 14.

Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria.

Introduction: Early diagnosis and prompt and effective treatment is one of the pillars of malaria control. Malaria case management guidelines recommend diagnostic testing before treatment using malaria Rapid Diagnostic Test (mRDT) or microscopy and this was adopted in Nigeria in 2010. However, despite the deployment of mRDT, the use of mRDTs by health workers varies by settings. Read More

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December 2018

Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas: Recommendations from the International Society of Gynecological Pathologists.

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S25-S39

Pathology Department, University of California San Francisco, San Francisco, California (J.T.R.) Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada (C.B.G.) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M.) Department of Pathology, University Hospital Arnau de Vilanova and Department of Pathology, University Hospital de Bellvitge, University of Lleida, IRBLLEIDA, IDIBELL, CIBERONC, Spain (X.M.G.) Department of Pathology, New York University Langone Medical Center, New York, New York (K.M.) Department of Pathology, Brigham and Women's Hospital (G.L.M.) Pathology Department, Massachusetts General Hospital (E.O.), Boston, Massachusetts Pathology Department, Yale New Haven Hospital, New Haven, Connecticut (V.P.) Department of Pathology, Johns Hopkins Medical Institutions (B.M.R.) Department of Pathology, University of Maryland School of Medicine (P.S.), Baltimore, Maryland Department of Histopathology, King Edward Memorial Hospital and School for Women's and Infants' Health, University of Western Australia, Perth, Australia (C.J.R.S.) Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK (W.G.M.).

This article provides practical recommendations developed from the International Society of Gynecological Pathologists Endometrial Carcinoma Project to address 4 issues that may arise in the diagnosis of uterine corpus low-grade endometrioid carcinoma: (1) The distinction between atypical hyperplasia and low-grade endometrioid carcinoma. (2) The distinction between low-grade endometrioid carcinoma and serous carcinoma. (3) The distinction between corded and hyalinized or spindle cell variants of low-grade endometrioid carcinoma and carcinosarcoma. Read More

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January 2019

Diet and colon: what matters?

Curr Opin Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.

Purpose Of Review: Colorectal cancer (CRC) is one of the most common cancers and the fourth leading cause of cancer-related deaths worldwide. Diet has a significant impact on the risk of developing CRC, but though processed meat is a known positive contributor, the effects of other dietary components are largely mixed. This review focuses on dietary patterns to describe the complexity of dietary diversity and overall food consumption and to examine the relationship between dietary patterns and risk of CRC. Read More

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December 2018
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EGFR-Mutant Adenocarcinomas That Transform to Small-Cell Lung Cancer and Other Neuroendocrine Carcinomas: Clinical Outcomes.

J Clin Oncol 2018 Dec 14:JCO1801585. Epub 2018 Dec 14.

1 Massachusetts General Hospital, Boston, MA.

Purpose: Approximately 3% to 10% of EGFR (epidermal growth factor receptor) -mutant non-small cell lung cancers (NSCLCs) undergo transformation to small-cell lung cancer (SCLC), but their clinical course is poorly characterized.

Methods: We retrospectively identified patients with EGFR-mutant SCLC and other high-grade neuroendocrine carcinomas seen at our eight institutions. Demographics, disease features, and outcomes were analyzed. Read More

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December 2018

Nocturnal ventricular repolarization lability predicts cardiovascular mortality in the Sleep Heart Health Study.

Am J Physiol Heart Circ Physiol 2018 Dec 14. Epub 2018 Dec 14.

Institut für Biomedizinische Technik, TU Dresden.

Background-The objective of this study was to quantify repolarization lability and its association with sex, sleep stage and cardiovascular mortality. Methods-We analyzed polysomnographic recordings of 2,263 participants enrolled in the Sleep heart health study (SHHS-2). Beat-to-beat QT interval variability (QTV) was quantified for consecutive epochs of 5 minutes according to the dominant sleep stage (AWAKE, NREM2, NREM3, REM). Read More

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December 2018

Surprisal modulates dual-task performance in older adults: Pupillometry shows age-related trade-offs in task performance and time-course of language processing.

Psychol Aging 2018 Dec;33(8):1168-1180

Department of Psychology.

Even though older adults are known to have difficulty at language processing when a secondary task has to be performed simultaneously, few studies have addressed how older adults process language in dual-task demands when linguistic load is systematically varied. Here, we manipulated surprisal, an information theoretic measure that quantifies the amount of new information conveyed by a word, to investigate how linguistic load affects younger and older adults during early and late stages of sentence processing under conditions when attention is split between two tasks. In high-surprisal sentences, target words were implausible and mismatched with semantic expectancies based on context, thereby causing integration difficulty. Read More

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December 2018

Handshaking promotes deal-making by signaling cooperative intent.

J Pers Soc Psychol 2018 Dec 13. Epub 2018 Dec 13.

Department of Marketing, Harvard Business School.

We examine how a simple handshake-a gesture that often occurs at the outset of social interactions-can influence deal-making. Because handshakes are social rituals, they are imbued with meaning beyond their physical features. We propose that during mixed-motive interactions, a handshake is viewed as a signal of cooperative intent, increasing people's cooperative behavior and affecting deal-making outcomes. Read More

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December 2018

Is developmental change in gender-typed behavior associated with adult sexual orientation?

Dev Psychol 2018 Dec 13. Epub 2018 Dec 13.

Carolina Population Center, Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill.

The goal of this article was to examine gender-typed behavior longitudinally and to consider its relationship with sexual orientation in adulthood. Data were from 10,624 respondents who completed Wave 1 (adolescence), Wave 3 (emerging adulthood), and Wave 4 (early adulthood) of the National Longitudinal Study of Adolescent to Adult Health. First, we described the distributions of gender-typed behavior by adult sexual orientation at each of the three developmental stages. Read More

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December 2018
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Age differences in everyday stressor-related negative affect: A coordinated analysis.

Psychol Aging 2018 Dec 13. Epub 2018 Dec 13.

Department of Biobehavioral Health and Medicine.

Advancing age is often characterized by preserved or even enhanced emotion regulation, which is thought to manifest in terms of age-related reductions in the within-person association between stressors and negative affect. Existing research from ecological momentary assessment and end-of-day daily diary studies examining such age-related benefits have yielded mixed results, potentially due to differences in samples, design, and measurement of everyday stressors and negative affect. We conducted a coordinated analysis of 5 ecological momentary assessments and 2 end-of-day daily diary studies to examine adult age differences in the within-person association between everyday stressors and negative affect. Read More

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December 2018

Prevention of anxiety and depression in school children: Effectiveness of the transdiagnostic EMOTION program.

J Consult Clin Psychol 2018 Dec 13. Epub 2018 Dec 13.

Centre for Child and Adolescent Mental Health, Eastern and Southern Norway.

Objective: The objective of the study was to examine the effectiveness of a transdiagnostic program (EMOTION, Coping Kids Managing Anxiety and Depression) targeting symptoms of anxiety and depression in schoolchildren by comparing the intervention condition (EC) to a control condition (CC).

Method: A clustered randomized design was used with schools as the unit of randomization. Children ( = 1686) aged 8-12 years in 36 schools completed screening using the Multidimensional Anxiety Scale (MASC-Child) and The Mood and Feelings Questionnaire Short version (SMFQ-Child). Read More

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December 2018

[Analysis of infants with moderate to severe laryngomalacia].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1406-1409

Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Xiamen University, Xiamen, 361003, China.

To investigate the clinical features and the treatment of moderate-severe laryngeallacia, and the application of CO₂laser supraglotation in laryngeallacia.Collecting the clinical data of 18 infants with moderate-to-severe laryngeallacia diagnosed in our hospital,10 cases were moderate. Eight cases were severe children; according to the classification of laryngeallacia, most of them were mixed type, including 2 cases of type Ⅱ, 3 cases of type Ⅲ, 5 cases of typeⅠ + type Ⅱ, 7 cases of typeⅡ+ type Ⅲ, and 1 case of typeⅠ+ typeⅡ + type Ⅲ. Read More

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September 2018

[Application of technique of HRCT and multipliate plane reconstruction in analysis of image features of superior semicircular canal dehiscence].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1082-1085;1090

Department of Radiology, Southern Medical University Nanfang Hospital.

Application of technique of high resolution CT (HRCT) and multipliate plane reconstruction, analyzed the image features of suspicious superior semicircular canal dehiscence (SSCD) to improve the understanding of the SSCD.From January 2016 to April 2017, a total of 230 adult patients who checked temporal bone HRCT were collected in this retrospective study, of which 160 cases (320 ears) of the non-SSCD, 73 cases were male (146 ears), 87 cases were female (174 ears), aged 18 to 70 years old; 70 cases (113 ears) were suspicious diagnosed with SSCD, 33 cases were male (55 ears), 37 cases were female (58 ears), and 18 to 71 years old. The thin section CT scan of the temporal bone translocation was performed on all subjects, then the CT post processing workstation was used for multipliate plane reconstruction (MPR), and the main rows of coronal and oblique sagittal image reconstruction was performed. Read More

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[Hemodialysis treatment as a trigger cause of cryoglobulinemic purpura: a case report].

G Ital Nefrol 2018 Dec;35(6)

U.O.C. Nefrologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, ROMA.

We describe the clinical case of a patient who developed mixed cryoglobulinemia syndrome after hemodialysis treatment with dialysate temperature lower than 36°C despite the negativization of the viral genome for HCV after eradication therapy. Read More

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December 2018

Heterogeneity of Treatment Effects of Long-Acting Injectable Antipsychotic Medications.

J Clin Psychiatry 2018 Nov 27;80(1). Epub 2018 Nov 27.

Department of Psychiatry and Health Behaviors, Augusta University Health, Augusta, Georgia, USA.

Objective: To investigate subgroup responses to long-acting injectable (LAI) medications haloperidol decanoate (HD) and paliperidone palmitate (PP) in a randomized controlled trial that found no difference between the treatments on the primary outcome of efficacy failure.

Methods: A Comparison of Long-Acting Injectable Medications for Schizophrenia (ACLAIMS) enrolled 311 participants from March 2011 to July 2013 meeting DSM-IV-TR criteria for diagnoses of schizophrenia or schizoaffective disorder at risk of relapse due to medication nonadherence or substance abuse. Participants were randomly assigned to double-blinded treatment with HD or PP and followed for up to 2 years. Read More

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November 2018

Abrupt Symptom Improvements in Antidepressant Clinical Trials: Transient Placebo Effects or Therapeutic Reality?

J Clin Psychiatry 2018 Dec 4;80(1). Epub 2018 Dec 4.

Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, USA.

Background: According to prevailing models and classical reports, abrupt responses to antidepressant medication are not true drug responses but rather transient placebo effects. By contrast, recent reports suggest that early sudden improvements have a lasting effect and appear in most patients receiving medication. Clinical guidelines influenced by these contradictory findings are mixed and confusing. Read More

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December 2018

Clinical Results of Anti-adhesion Adjuvants after Endonasal Dacryocystorhinostomy.

Korean J Ophthalmol 2018 Dec;32(6):433-437

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.

Purpose: Various absorbable anti-adhesion agents have been used to prevent postoperative synechia formation after endonasal surgery. The purpose of this study was to evaluate the anti-adhesion effects of HyFence and Mediclore after endonasal dacryocystorhinostomy (DCR) compared to a mixed solution of hyaluronic acid and sodium carboxymethylcellulose (Guardix-Sol).

Methods: In this retrospective study, endonasal DCR and silicone tube intubation were performed on 198 eyes of 151 patients. Read More

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December 2018

Four Decades of Public Participation in Risk Decision Making.

Risk Anal 2018 Dec 14. Epub 2018 Dec 14.

Social and Environmental Research Institute, Northampton, MA, USA.

Over the past four decades, the promise of public participation to improve decisions, obtain legitimacy, and build capacity for risk decision making and management has had a mixed record. In this article, we offer a narrative of how public participation has evolved in the United States and we examine prospects for its future. We trace three forces that have had significant impact on practice: an emergent emphasis on democratic deliberation, a transition from dichotomous thinking about science versus politics to an integrated perspective, and the recognition that different parties to the decision-making process bring valid epistemological contributions. Read More

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December 2018

A Flow Cytometry-Based Assay for High-Throughput Detection and Quantification of Neutrophil Extracellular Traps in Mixed Cell Populations.

Cytometry A 2018 Dec 14. Epub 2018 Dec 14.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Neutrophil extracellular traps (NETs) are web-like structures composed of decondensed chromatin and antimicrobial proteins that are released into the extracellular space during microbial infections. This active cell death program is known as NETosis. To date, florescence microscopy is the widely accepted method for visualization and quantification of NETs. Read More

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December 2018

Straightforward Ball-Milling Access to Dinucleoside 5',5'-Polyphosphates Through Phosphorimidazolide Intermediates.

Chemistry 2018 Dec 14. Epub 2018 Dec 14.

Universite de Montpellier, IBMM, Place Eugène Bataillon, 34095, Montpellier, FRANCE.

A solvent-assisted mechanochemical approach to access symmetrical and mixed dinucleoside 5,5'-polyphosphates is reported. Under ball-milling conditions, nucleoside 5'-monophosphates are quantitatively activated using N,N'-carbonyldiimidazole into their phosphorimidazolide derivatives. The addition of a nucleoside 5'-mono, di or triphosphate directly leads to the formation of the corresponding dinucleotides. Read More

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December 2018

Helping Her Heal: Randomized Clinical Trial to Enhance Dyadic Outcomes in Couples.

Psychooncology 2018 Dec 13. Epub 2018 Dec 13.

University of Washington, School of Nursing, Seattle, WA.

Objective: To test the short-term efficacy of a brief, fully manualized marital communication and interpersonal support intervention for couples facing recently diagnosed breast cancer.

Methods: A total of 322 women diagnosed within 6 months with Stage 0-III breast cancer and their 322 spouse caregivers were enrolled. Spouses in the experimental group received five, 30 to 60-minute intervention sessions at 2-week intervals by Masters prepared patient educators; controls received the booklet, "What's Happening to the Woman I Love?" Outcomes were assessed at 3, 6 and 9 months using Linear Mixed Models within an intent to treat analysis. Read More

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December 2018

Longitudinal change in the cerebroplacental ratio and the risk of stillbirth.

Ultrasound Obstet Gynecol 2018 Dec 13. Epub 2018 Dec 13.

Fetal Medicine Unit, St George's Hospital, St George's University of London, UK Cranmer Terrace, London, SW17 0RE.

Objectives: To investigate whether the longitudinal Doppler changes in small-for-gestational age (SGA) fetuses improves the prediction of those at risk of intrauterine fetal death (IUFD).

Methods: A longitudinal study using two cohorts of singleton pregnancies (SGA and appropriate for gestational age [AGA]). The inclusion criteria for the SGA cohort were singleton pregnancies at 20 weeks' gestation or beyond and diagnosed with SGA. Read More

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December 2018

Enhancing the oral bioavailability of baicalein via Solutol HS15 and Poloxamer 188 mixed micelles system.

J Pharm Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Objectives: To increase the solubility of baicalein (BAI) by preparing BAI-micelles (BAI-M) with Solutol HS15 (HS15) and Poloxamer 188 (F68), thereby improving its oral bioavailability.

Methods: Baicalein micelles were prepared with HS15 and F68 by thin-film dispersion method and optimized by central composite design (CCD) approach. Physicochemical, in vitro release, Caco-2 cell transport and pharmacokinetic studies of BAI-M were performed. Read More

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December 2018

Lactation intensity and duration to postpartum diabetes and prediabetes in women with gestational diabetes.

Diabetes Metab Res Rev 2018 Dec 13:e3115. Epub 2018 Dec 13.

Pennington Biomedical Research Center, Baton Rouge, LA.

Objective: To investigate the association of lactation intensity and duration with postpartum diabetes and prediabetes risks among Chinese women with a history of GDM.

Methods: We included 1260 women with a history of GDM who participated in the whole populationꞋs GDM universal screening survey by using World Health OrganizationꞋs criteria. Lactation intensity and lactation duration were collected by a standardized questionnaire. Read More

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December 2018

Geographical adaptation prevails over species-specific determinism in trees' vulnerability to climate change at Mediterranean rear-edge forests.

Glob Chang Biol 2018 Dec 13. Epub 2018 Dec 13.

Ecoclimatology, Department of Ecology and Ecosystem Management, Technische Universität München, Freising, Germany.

Climate change may reduce forest growth and increase forest mortality, which is connected to high carbon costs through reductions in gross primary production and net ecosystem exchange. Yet the spatiotemporal patterns of vulnerability to both short-term extreme events as well as gradual environmental changes are quite uncertain across the species' limits of tolerance to dryness. Such information is fundamental for defining ecologically relevant upper limits of species tolerance to drought and hence, to predict the risk of increased forest mortality and shifts in species composition. Read More

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December 2018

High-Performance Photoinduced Memory with Ultrafast Charge Transfer Based on MoS /SWCNTs Network Van Der Waals Heterostructure.

Small 2018 Dec 13:e1804661. Epub 2018 Dec 13.

State Key Laboratory for Chemo/Biosensing and Chemometrics, School of Physics and Technology, Wuhan University, Wuhan, 430072, China.

Photoinduced memory devices with fast program/erase operations are crucial for modern communication technology, especially for high-throughput data storage and transfer. Although some photoinduced memories based on 2D materials have already demonstrated desirable performance, the program/erase speed is still limited to hundreds of micro-seconds. A high-speed photoinduced memory based on MoS /single-walled carbon nanotubes (SWCNTs) network mixed-dimensional van der Waals heterostructure is demonstrated here. Read More

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December 2018

A study to investigate the impact of a blended learning teaching approach to teach pharmacy law.

Int J Pharm Pract 2018 Dec 13. Epub 2018 Dec 13.

School of Pharmacy, Newcastle University, Newcastle upon Tyne, UK.

Objective: To describe the implementation and assess the effect of a blended learning approach to teach pharmacy law.

Methods: Twenty didactic pharmacy law lectures were redeveloped to 9 h of flipped classroom sessions. Presession online videos delivered factual content created in-house. Read More

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December 2018

Toxicological evaluation of metal oxide nanoparticles and mixed exposures at low doses using zebra fish and THP1 cell line.

Environ Toxicol 2018 Dec 12. Epub 2018 Dec 12.

Department of Biotechnology, University Institute of Engineering and Technology (UIET), Panjab University, Chandigarh, India.

Metal and metal oxide nanoparticles are being used in different industries now-a-days leading to their unavoidable exposure to humans and animals. In the present study, toxicological testing was done using nanoparticles of copper oxide, cerium oxide and their mixture (1:1 ratio) on zebra fish embryos and THP-1 cell line. Zebrafish embryos were exposed to 0. Read More

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December 2018