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    Cardiac arrhythmias in adolescents with mitral valve prolapse and myxomatous degeneration of mitral valve leaflets.
    Wiad Lek 2016 ;69(6):730-733
    Department Of Clinical Pharmacology Of Kharkiv National Medical University, Kharkiv, Ukraine.
    Introduction: myxomatous degeneration (MD) of valve leaflets and other structures of the valve apparatus and the degree of its severity in particular is of great prognostic significance as this determines the risk of complications development as well as the prognosis. The aim of the paper was to assess heart rhythm and heart conduction disorders in adolescents with primary mitral valve prolapse (MVP) and myxomatous valve degeneration of various degrees.

    Materials And Methods: complete physical examination of 145 adolescents aged 12-16 with MVP was carried out. Read More

    Robotic mitral valve repair for degenerative posterior leaflet prolapse.
    Ann Cardiothorac Surg 2017 Jan;6(1):27-32
    Background: Robotic mitral valve (MV) repair is the least invasive surgical approach to the MV and provides unparalleled access to the valve. We sought to assess technical aspects and clinical outcomes of robotic MV repair for isolated posterior leaflet prolapse by examining the first 623 such cases performed in a tertiary care center.

    Methods: We reviewed the first 623 patients (mean age 56±9. Read More

    The adjustable slipknot technique for implanting neochordae in the repair of mitral valve prolapse.
    Multimed Man Cardiothorac Surg 2016 Dec 6;2016. Epub 2016 Dec 6.
    The adjustable slipknot technique is a novel procedure for implanting neochordae. The neochorda acts like a lasso. The procedure facilitates accurate assessment of the length of the neochordae. Read More

    Evaluation of Prolonged QT interval: Structural Heart Disease Mimicking Long QT Syndrome.
    Pacing Clin Electrophysiol 2017 Feb 3. Epub 2017 Feb 3.
    Division of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
    Background: In about 20-25% of patients with congenital long QT syndrome (LQTS) a causative pathogenic mutation is not found. The aim of this study was to explore the prevalence of alternative cardiac diagnoses among patients exhibiting prolongation of QT interval with negative genetic testing for LQTS genes.

    Methods: We conducted a retrospective analysis of 239 consecutive patients who were evaluated in the inherited arrhythmia clinic at the Toronto General Hospital between July 2013 and December 2015 for possible LQTS. Read More

    Transapical beating-heart chordae implantation in mitral regurgitation: a new horizon for repairing mitral valve prolapse.
    J Thorac Dis 2016 Dec;8(12):E1665-E1671
    Cardiovascular Department, GVM Care and Research, Maria Eleonora Hospital, Palermo, Italy; ; Department of Surgery and Cancer, University of Palermo, Palermo, Italy.

    Ischemic mitral valve prolapse.
    J Thorac Dis 2016 Dec;8(12):3752-3761
    Department of Cardiovascular Surgery, University Campus Bio-Medico di Roma, Rome, Italy.
    Ischemic mitral prolapse (IMP) is a pathologic entity encountered in about one-third among the patients undergoing surgery for ischemic mitral regurgitation (IMR). IMP is generally the result of a papillary muscle injury consequent to myocardial, but the recent literature is progressively unveiling a more complex pathogenesis. The mechanisms underlying its development regards the impairment of one or more components of the mitral apparatus, which comprises the annulus, the chordae tendineae, the papillary muscle and the left ventricular wall. Read More

    Twist deformation for predicting postoperative left ventricular function in patients with mitral regurgitation: A speckle tracking echocardiography study.
    Echocardiography 2017 Jan 28. Epub 2017 Jan 28.
    Kartal Kosuyolu Heart & Research Hospital, Cardiology Clinic, Istanbul, Turkey.
    Purpose: Postoperative LV dysfunction is associated with poor prognosis and increased mortality in patient with mitral regurgitation undergoing surgery. With this study, we aimed to investigate the predictive value of classic and speckle tracking echocardiographic (STE) LV deformational parameters for estimating postoperative LV dysfunction.

    Methods: Fifty-nine asymptomatic patients with severe mitral regurgitation (MR) due to mitral valve prolapse, who had sinus rhythm and LV ejection fraction (EF) ≥50%, were included. Read More

    A systematic review and meta-analysis of chordal replacement versus leaflet resection for isolated posterior mitral valve prolapse.
    J Cardiovasc Surg (Torino) 2017 Jan 25. Epub 2017 Jan 25.
    Division of Cardiology at Columbia University, Mount Sinai Heart Institute, Miami, FL, USA.
    Introduction: Chordal replacement (Chord MVr) for isolated posterior mitral valve prolapse allows for preservation of the native mitral valve apparatus. The potential benefits of this approach, as compared with leaflet resection (Resection), are not clearly defined.

    Evidence Acquisition: A systematic review and meta-analysis was conducted on operative, clinical, and echocardiographic outcomes. Read More

    Coexistence of abnormal systolic motion of mitral valve in a consecutive group of 324 adult Tetralogy of Fallot patients assessed with echocardiography.
    Open Heart 2016 30;3(2):e000518. Epub 2016 Dec 30.
    University of California San Francisco (UCSF) , San Francisco, California , USA.
    Background: The presence of mitral valve prolapse (MVP) in congenital heart disease (CHD) patients is not well described. Tetralogy of Fallot (TOF) is the most common cyanotic CHD associated with overall good long-term survival after palliation. Since MVP is more often identified in adults and TOF patients are now surviving longer, we thus sought to perform this cohort study with a case-control design to (1) determine the prevalence of MVP and systolic displacement of mitral leaflets (SDML) in adult TOF patients, and (2) describe their clinical and imaging characteristics. Read More

    The adjustable slipknot technique for implanting neochordae in the repair of mitral valve prolapse.
    Multimed Man Cardiothorac Surg 2016 Dec 6;2017. Epub 2016 Dec 6.
    The adjustable slipknot technique is a novel procedure for implanting neochordae. The neochorda acts like a lasso. The procedure facilitates accurate assessment of the length of the neochordae. Read More

    Optimal surgical mitral valve repair in Barlow's disease: the concept of functional prolapse.
    Multimed Man Cardiothorac Surg 2016 12 6;2017. Epub 2016 Dec 6.
    Barlow's disease presents the most severe form of degenerative mitral valve disease as it normally affects various valvular structures and segments. We discuss the technical aspects of mitral valve repair in this setting. Furthermore, the concept of "functional prolapse" of the mitral valve is discussed as well as recommendations on when to proceed with surgical correction of anterior leaflet prolapse. Read More

    Simplified mitral valve repair in pediatric patients with connective tissue disorders.
    J Thorac Cardiovasc Surg 2017 Feb 23;153(2):399-403. Epub 2016 Sep 23.
    Division of Cardiac Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
    Background: In pediatric patients with connective tissue disorders (CTDs), early cardiac presentation often involves severe mitral regurgitation (MR) associated with severe bileaflet prolapse and, less frequently, aortic root enlargement. We adopted a simplified repair to address MR and prevent systolic anterior motion (SAM) in this unique group of patients.

    Materials And Methods: Retrospective review of clinical and echocardiographic data of all pediatric patients (age < 18 years) with CTD and MR undergoing simplified repair at 3 institutions (2000-2014). Read More

    Numerical simulation of mitral valve prolapse considering the effect of left ventricle.
    Math Biosci 2017 Mar 28;285:75-80. Epub 2016 Dec 28.
    Biological Fluid Dynamics Laboratory, Biomedical Egngineering Faculty, Amirkabir University of Technology, Tehran, Iran.
    Heart failure is one of the most important issues that has been investigated in recent research studies. Variations that occur in apparatus of mitral valve, such as chordae tendineaea rupture, can affect the valve function during ventricular contraction and lead to regurgitation from the left ventricle into the left atrium. One method for understanding mitral valve function in such conditions is computational analysis. Read More

    Endovascular Repair of Bilateral Internal Mammary Artery Aneurysms in a Patient with Marfan Syndrome-A Case Report.
    Int J Angiol 2016 Dec 24;25(5):e39-e42. Epub 2014 Jun 24.
    Division of Cardiology, Loyola University Medical Center, Chicago, Illinois.
    Marfan syndrome (MFS) is an autosomal dominant condition that is caused by abnormal synthesis of connective tissue. The syndrome classically affects the ocular, musculoskeletal, and cardiovascular systems. The most common cardiovascular manifestations include mitral valve prolapse/regurgitation and aortic aneurysms at high risk of rupture and dissection. Read More

    A Yellow Papular Eruption on the Arms, Legs, and Neck: A Rare Masquerader.
    Skinmed 2016 1;14(6):465-466. Epub 2016 Dec 1.
    Department of Dermatology, Saint Louis University School of Medicine, St. Louis, MO.
    A 54-year-old Caucasian woman with a medical history of mitral valve prolapse presented with a 5-year history asymptomatic papules. There was no family history of similar lesions. Physical examination revealed >100, 2- to 4-mm, firm, yellow, dermal papules located on the neck, antecubital and popliteal fossae, flexor surface of both forearms, and inner aspect of the thighs (Figure 1). Read More

    Chordal Shortening for Anterior Mitral Leaflet Prolapse and the Maze Procedure for Persistent Atrial Fibrillation.
    J Heart Valve Dis 2016 Jul;25(4):525-526
    Department of Thoracic and Cardiovascular Surgery, Research Institute of Clinical Medicine and Biomedical Research Institute, Chonbuk National University Medical School, Jeonju, Chonbuk, South Korea.
    Letter to the Editor We read with great interest the report by Inoue et al. (Cusp-level chordal shortening for non-rheumatic mitralanterior leaflet prolapse in a patient with persistent atrial fibrillation. J Heart Valve Dis 2015;24:586-589) that described their mitral valve repair technique for anterior leaflet prolapse (ALP) and perioperative adaptive servo-ventilation (ASV) therapy for preventing the recurrence of atrial fibrillation after the maze procedure. Read More

    Off-Pump NeoChord Mitral Valve Repair to Simultaneously Treat Posterior Leaflet Prolapse and Systolic Anterior Motion.
    Ann Thorac Surg 2017 Jan;103(1):e29-e30
    Department of Surgical Sciences, Division of Cardiac Surgery, Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.
    This case represents the first report of complete elimination of systolic anterior motion by beating-heart implantation of artificial chordae tendineae on a prolapsing and redundant posterior leaflet. Read More

    Surgical Treatment of Posterior Mitral Valve Prolapse: Towards 100% Repair.
    J Heart Valve Dis 2015 Nov;24(6):752-759
    Centre of Cardiothoracic Surgery, University Hospital and Faculty of Medicine of Coimbra, Portugal.
    Background: The study aim was to evaluate the immediate and long-term results of surgical treatment of isolated posterior mitral valve leaflet prolapse (PLP), focusing on survival and freedom from recurrent mitral regurgitation (MR).

    Methods: Between January 1998 and December 2012, a total of 492 consecutive patients (375 males, 117 females; mean age 61.8 ± 12. Read More

    Repair of Anterior Mitral Leaflet Prolapse: Comparison of Mid-Term Outcomes with Chordal Transposition and Chordal Replacement Techniques.
    J Heart Valve Dis 2016 Mar;25(2):187-194
    Department of Cardiac Surgery, Montreal Heart Institute, Quebec, Canada.
    Background: The repair of anterior mitral leaflet prolapse is known to be challenging. Hence, the study aim was to compare the mid-term results of anterior leaflet prolapse (ALP) using chordal transposition with results obtained using chordal replacement with expanded polytetrafluoroethylene (ePTFE) sutures.

    Methods: Between 1999 and 2012, a total of 96 consecutive patients (mean age 62 years) with ALP underwent mitral valve repair at the authors' institution. Read More

    Distant Position of Chordae from Coaptation Causes Mitral Regurgitation in Patients with Atrial Fibrillation.
    J Heart Valve Dis 2016 May;25(3):323-331
    Noninvasive Cardiac Laboratory, Cedars-Sinai Heart Institute, Los Angeles, CA, USA. Electronic correspondence:
    Background: The study aim was to investigate the mechanism of mitral regurgitation (MR) in lone atrial fibrillation (AF) patients using three-dimensional (3D) transesophageal echocardiography (TEE).

    Methods: A retrospective analysis was conducted of 64 patients with AF and a normal left ventricle, and without prolapse of the mitral valve. Among these patients, significant MR was not identified in 33 cases (AF+MR- group) but was present in 31 cases (AF+MR+ group). Read More

    Technical aspects of robotic posterior mitral valve leaflet repair.
    Ann Cardiothorac Surg 2016 Nov;5(6):577-581
    Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.
    Posterior mitral valve leaflet repair is safe, effective and durable and can be performed through conventional sternotomy or by using minimally invasive thoracoscopic or robotic-assisted approaches. Triangular resection with ventricularization, quadrangular resection with sliding or folding leaflet reconstruction, neochordae implantation and edge-to-edge leaflet repair are different techniques for eliminating the prolapsing mitral leaflet segment and restoring normal leaflet coaptation. Recent studies have demonstrated that minimally invasive approaches are associated with a reduced risk of postoperative complications, shorter hospital stay and improved cosmetic outcomes when compared to conventional sternotomy. Read More

    Evaluation of Echocardiographic Abnormalities in HIV Positive Patients Treated with Antiretroviral Medications.
    Infect Disord Drug Targets 2016 Dec 5. Epub 2016 Dec 5.
    Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Echocardiography is a reliable means for the diagnosis of functional and valvular diseases of the heart in HIV positive and HIV negative patients. The current study was to evaluate echocardiographic abnormalities in HIV positive patients under an antiretroviral therapy (ART) program in Tehran, Imam Khomeini Hospital, Iran.

    Methods: This is a descriptive cross-sectional study, conducted among 231 HIV positive patients under ART. Read More

    Neochord placement versus triangular resection in mitral valve repair: A finite element model.
    J Surg Res 2016 Nov 15;206(1):98-105. Epub 2016 Jul 15.
    Department of Surgery, University of California, San Francisco, California; Department of Bioengineering, University of California, San Francisco, California; Department of Surgery, Veterans Affairs Medical Center, San Francisco, California. Electronic address:
    Background: Recurrent mitral regurgitation after mitral valve repair is common, occurring in nearly 50% of patients within 10 years of surgery. Durability of repair is partly related to stress distribution over the mitral leaflets. We hypothesized that repair with neochords (NCs) results in lower stress than leaflet resection (LR). Read More

    A hospital-based survey of patients with severe valvular heart disease in China.
    Int J Cardiol 2017 Mar 25;231:244-247. Epub 2016 Nov 25.
    Department of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China. Electronic address:
    Objectives: Due to increasing aging, the epidemiology of VHD may have changed in China. This study aimed to provide contemporary information on the prevalence, distribution patterns, and etiology of severe VHD in China.

    Methods: This was a retrospective survey at Second Affiliated Hospital of Zhejiang University, which included all consecutive patients between 2010 and 2015. Read More

    Twenty-Year Outcome After Mitral Repair Versus Replacement for Severe Degenerative Mitral Regurgitation: Analysis of a Large, Prospective, Multicenter, International Registry.
    Circulation 2017 Jan 29;135(5):410-422. Epub 2016 Nov 29.
    From Université Catholique de Louvain, Brussels, Belgium (S.L., J.-L.V., C.d.M., A.P.); Mayo Clinic College of Medicine, Rochester, MN (H.I.M., M.H., J.M., M.-A.C., M.E.-S.); University of Bologna, Italy (F.G., A.R.); Inserm, ERI-12, University Hospital, Amiens, France (C.T., D.R., C.S.); Aix-Marseille Université, Marseille, France (J.-F.A.); University of Modena, Italy (A.B.); and Cleveland Clinic, Department of Thoracic and Cardiac Surgery, OH (R.M.S.).
    Background: Mitral valve (MV) repair is preferred over replacement in clinical guidelines and is an important determinant of the indication for surgery in degenerative mitral regurgitation. However, the level of evidence supporting current recommendations is low, and recent data cast doubts on its validity in the current era. Accordingly, the aim of the present study was to analyze very long-term outcome after MV repair and replacement for degenerative mitral regurgitation with a flail leaflet. Read More

    Anaesthetic Management of a Case of Down's Syndrome with Achalasia Cardia.
    J Clin Diagn Res 2016 Oct 1;10(10):UD03-UD05. Epub 2016 Oct 1.
    Post Graduate, Department of Anesthesiology, Kasturba Medical College, Manipal University , Mangalore, Karnataka, India .
    Achalasia cardia is a disorder of the gastrointestinal tract characterized by dilatation of the oesophagus and collection of food and fluids in the oesophagus leading to massive regurgitation and aspiration of gastric contents. Down's syndrome has multisystem effects which can also present as difficult airway. Here, we present a case of a 14-year-old girl, a case of Down's syndrome with Achalasia cardia and mitral valve prolapse posted for Heller's cardiomyotomy. Read More

    Severe mitral regurgitation due to mitral leaflet aneurysm diagnosed by three-dimensional transesophageal echocardiography: a case report.
    BMC Cardiovasc Disord 2016 Nov 22;16(1):234. Epub 2016 Nov 22.
    Department of Cancer Pathology, Hokkaido University, Graduate School of Medicine, Sapporo, Japan.
    Background: A small mitral valve aneurysm (MVA) presenting as severe mitral regurgitation (MR) is uncommon.

    Case Presentation: A 47-year-old man with a history of hypertension complained of exertional chest discomfort. A transthoracic echocardiogram (TTE) revealed the presence of MR and prolapse of the posterior leaflet. Read More

    Percutaneous closure of isolated ostium secundum-type atrial septal defect in a patient with Mayer-Rokitansky-Küster-Hauser syndrome.
    Rev Port Cardiol 2016 Dec 16;35(12):701.e1-701.e3. Epub 2016 Nov 16.
    Department of Radiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
    Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare congenital anomaly characterized by complete or partial aplasia of the uterus and the upper part of the vagina. It is reported to be associated with cardiovascular disorders including atrial septal defect, anomalous pulmonary venous return, aortopulmonary window, pulmonary valve stenosis, mitral valve prolapse, tetralogy of Fallot, truncus arteriosus, and patent ductus arteriosus. Herein, for the first time in the medical literature, we present percutaneous closure of an isolated ostium secundum atrial septal defect in this syndrome. Read More

    In vitro and in silico approaches to quantify the effects of the Mitraclip(®) system on mitral valve function.
    J Biomech 2017 Jan 10;50:83-92. Epub 2016 Nov 10.
    Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.
    Mitraclip(®) implantation is widely used as a valid alternative to conventional open-chest surgery in high-risk patients with severe mitral valve (MV) regurgitation. Although effective in reducing mitral regurgitation (MR) in the majority of cases, the clip implantation produces a double-orifice area that can result in altered MV biomechanics, particularly in term of hemodynamics and mechanical stress distribution on the leaflets. In this scenario, we combined the consistency of in vitro experimental platforms with the versatility of numerical simulations to investigate clip impact on MV functioning. Read More

    Should pre-operative left atrial volume receive more consideration in patients with degenerative mitral valve disease undergoing mitral valve surgery?
    Int J Cardiol 2017 Jan 8;227:106-113. Epub 2016 Nov 8.
    Department of Medicine and Surgery, Unit of Cardiology, Campus Bio-Medico University of Rome, Italy.
    Background: Severe primary mitral regurgitation (MR) carries a significant incidence of mortality and morbidity. Though a number of prognostic factors have been identified, the best timing for mitral valve repair is still debated. We assessed the role of Left Atrial Volume Indexed (LAVI) as predictor of adverse events after mitral valve surgery. Read More

    Left Atrial Remodeling in Segmental vs. Global Mitral Valve Prolapse - Three-Dimensional Echocardiography.
    Circ J 2016 Nov 9;80(12):2533-2540. Epub 2016 Nov 9.
    Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine.
    Background: Segmental and global mitral valve prolapse (MVP) comprise 2 representative phenotypes in this syndrome. While mitral regurgitation (MR) severity is a major factor causing left atrial (LA) remodeling in MVP, prominent mitral valve (MV) annulus dilatation in global MVP may specifically cause inferiorly predominant LA remodeling. We compared MV annulus and LA geometry in patients with segmental and global MVP. Read More

    Clinical Characteristics of Marfan Syndrome in Korea.
    Korean Circ J 2016 Nov 24;46(6):841-845. Epub 2016 Oct 24.
    Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Background And Objectives: Marfan syndrome (MFS) is a connective tissue disorder with autosomal dominant inheritance and a highly variable clinical spectrum. However, there are limited data available on the clinical features of Korean patients with MFS. The aim of the present study was to describe the clinical characteristics and outcomes of Korean patients with MFS. Read More

    How Does Mitral Valve Repair Fail in Patients With Prolapse?-Insights From Longitudinal Echocardiographic Follow-Up.
    Ann Thorac Surg 2016 Nov 6;102(5):1459-1465. Epub 2016 Oct 6.
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada.
    Background: Repair of mitral regurgitation (MR) caused by prolapse has been well validated. Although favorable early and late results after repair have been reported, few data are available that mechanistically describe how a mitral repair fails beyond the mere need for mitral valve reoperation. We therefore sought to determine the modes of valve repair failure in patients who underwent surgical correction of MR caused by prolapse. Read More

    Incidental left anterior descending coronary artery to pulmonary artery fistula in myxomatous mitral valve prolapse.
    Indian Heart J 2016 Sep 5;68 Suppl 2:S88-S89. Epub 2016 Sep 5.
    Department of Cardiothoracic and Vascular Surgery, Medanta - The Medicity, Gurgaon, Haryana, India.
    Uniqueness of this case report is that though coronary cameral fistulas are itself rare, we closed fistula effectively in a different way. Since surgery was only good option available as patient had concomitant valvular disease, we closed distal end of fistula in PA and then took deep bites of suture in fistulous track itself. This approach closed fistula effectively and we had no need to dissect and ligate its origin from LAD which is more arduous and dangerous task. Read More

    Giant left atrium in undersized mitral ring annuloplasty.
    Monaldi Arch Chest Dis 2016 Oct 14;86(1-2):763. Epub 2016 Oct 14.
    Enlargement of left atrium occurs in patients with longstanding mitral valve disease due to chronic pressure and volume overload and occasionally left atrium reaches a massive enlargement, condition known as giant left atrium. It is most commonly associated with rheumatic mitral valve disease, both stenosis and regurgitation. This unique case deals with a 70-year-old woman who developed a giant left atrium due to a severe mitral regurgitation from complete prolapse of both mitral leaflets, as a consequence of previous undersized mitral ring annuloplasty. Read More

    Prognostic Importance of Exercise Brain Natriuretic Peptide in Asymptomatic Chronic Organic Severe Mitral Regurgitation: An Observational Study.
    J Clin Med Res 2016 Nov 29;8(11):797-804. Epub 2016 Sep 29.
    Department of Cardiology, LPS Institute of Cardiology, G. S. V. M. Medical College, Kanpur, Uttar Pradesh 208002, India.
    Background: The optimal timing of surgery in patients with chronic organic severe mitral regurgitation (MR) continues to be debated, especially for those who are asymptomatic. The aim of the study was to determine independent and additive prognostic value of exercise brain natriuretic peptide (eBNP) in patients with severe asymptomatic MR and normal left ventricular ejection fraction (LVEF).

    Methods: Two hundred twenty-three consecutive patients with severe MR defined by effective regurgitant orifice (ERO) area ≥ 40 mm(2) and/or residual volume ≥ 60 mL, LVEF > 60%, and normal LV end-systolic diameter < 40 mm underwent symptom limited exercise treadmill test (TMT). Read More

    QT dispersion and ventricular arrhythmias in children with primary mitral valve prolapse.
    Turk Pediatri Ars 2016 Sep 1;51(3):135-141. Epub 2016 Sep 1.
    Department of Pediatrics, Division of Pediatric Cardiology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey.
    Aim: To investigate ventricular arrhythmias in children with primary mitral valve prolapse and to evaluate its relation with QT length, QT dispersion, autonomic function tests and heart rate variability measurements.

    Material And Methods: Fourty two children with mitral valve prolapse and 32 healthy children were enrolled into the study. Twelve-lead electrocardiograms, autonomic function tests, echocardiography and 24-hour rhythm Holter tests were performed. Read More

    Basal Left Ventricular Dilatation and Reduced Contraction in Patients With Mitral Valve Prolapse Can Be Secondary to Annular Dilatation: Preoperative and Postoperative Speckle-Tracking Echocardiographic Study on Left Ventricle and Mitral Valve Annulus Interaction.
    Circ Cardiovasc Imaging 2016 Oct;9(10)
    From the Second Department of Internal Medicine (S.F., H.K., T.M., Y.O., S.S., Y.O.), Departments of Laboratory and Transfusion Medicine (M.T.), and Cardiovascular Surgery (M.E., Y.N.), University of Occupational and Environmental Health, Kitakyushu, Japan; Cardiac Imaging Center, Asan Medical Center Heart Institute, Seoul, South Korea (J.-K.S., J.Y.J., B.J.S., J.K.); Departments of Cardiology (K.M., S.T.) and Cardiovascular Surgery (K.M., S.T.), Sakakibara Heart Institute, Fuchu, Japan; and Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Boston (R.A.L.).
    Background: Prominent mitral valve (MV) annular dilatation with only modest left ventricular (LV) dilatation in patients with MV prolapse (MVP) suggests predominant dilatation in adjacent basal LV, which may augment regional wall tension and attenuate contraction by Laplace's law. We hypothesized that MV annular dilatation in patients with MVP is associated with the basal predominance of LV dilatation and attenuated contraction, which can be altered by surgical MV plasty with annulus reduction.

    Methods And Results: Echocardiography with speckle-tracking analysis to assess regional cross-sectional short-axis area and longitudinal contraction (strain) of basal, middle, and apical LV was performed in 30 controls and 130 patients with MVP. Read More

    Transapical off-pump mitral valve repair. First experience with the NeoChord system in Poland (report of two cases).
    Kardiol Pol 2017 7;75(1):7-12. Epub 2016 Oct 7.
    Medicover Hospital, Warsaw, Poland.
    Background: Artificial chord implantation to repair a flail or prolapsing mitral valve leaflet requires open heart surgery and cardiopulmonary bypass.

    Aim: Transapical off-pump artificial chordae implantation is a new surgical technique proposed to treat degenerative mitral valve regurgitation. The procedure is performed using the NeoChord DS1000 system (NeoChord, Inc. Read More

    Detecting Underlying Cardiovascular Disease in Young Competitive Athletes.
    Can J Cardiol 2017 Jan 23;33(1):155-161. Epub 2016 Jun 23.
    Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.
    Background: Sudden cardiac death (SCD) is frequently the first manifestation of underlying cardiovascular disease in young competitive athletes (YCAs), yet there are no Canadian guidelines for preparticipation screening in this population. The goal of this study was to determine the prevalence of potentially lethal cardiovascular disease in a sample of Canadian YCAs by comparing 2 screening strategies.

    Methods: We prospectively screened 1419 YCAs in British Columbia, Canada (age 12-35 years). Read More

    Mitral valve repair with the "respect" approach in dialysis-dependent patients: a single-center experience.
    Ann Transl Med 2016 Aug;4(16):302
    Department of Cardiac Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.
    Background: Morbidity and mortality risks in patients with end-stage renal disease (ESRD) undergoing mitral valve surgery are high; however, little is known regarding the risks and results of mitral valve repair in these patients.

    Methods: We retrospectively reviewed the clinical data of dialysis-dependent patients who underwent mitral valve repair with the "respect" approach between April 2012 and April 2015 in our institution.

    Results: All five identified patients survived and their data were included in the analysis. Read More

    The Role of Medical Therapy in Moderate to Severe Degenerative Mitral Regurgitation.
    Rev Cardiovasc Med 2016;17(1-2):28-39
    Cedars-Sinai Heart Institute, Los Angeles, CA.
    Mitral regurgitation (MR) is a common valvular disorder that has important health and economic consequences. Standardized guidelines exist regarding when and in whom to perform mitral valve surgery, but little information is available regarding medical treatment of MR. Many patients with moderate or severe MR do not meet criteria for surgery or are deemed to be at high risk for surgical therapy. Read More

    FLAIR Hyperintense Vessel Sign of Both MCAs with Severe Heart Failure.
    Case Rep Neurol Med 2016 25;2016:5169056. Epub 2016 Aug 25.
    Department of Neurology, Wonkwang University Sanbon Hospital, Sanbonro 321, Gunpo, Gyeonggi-do 15-865, Republic of Korea.
    Introduction. Fluid-attenuated inversion recovery hyperintense vessels (FHVs) can be seen in patients with occlusion or severe stenosis of the cerebral arteries. FHVs are known to reflect stagnant or slow blood flow within the cerebral artery. Read More

    Minimally Invasive Repair of Mitral Valve Prolapse and Concomitant Atrial Fibrillation Ablation in a Heart Transplant.
    Ann Thorac Surg 2016 Oct;102(4):e305-7
    Department of Cardiac Surgery, Ghent University Hospital, Ghent, Belgium.
    Significant mitral valve disease with atrial fibrillation after heart transplantation is unusual. We report the diagnosis and minimally invasive surgical treatment 17 years after transplantation, in which mitral valve repair together with left atrial ablation was performed, resulting in a satisfying clinical and echocardiographic improvement. Read More

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