7,133 results match your criteria Mitral Valve Prolapse


A rare case of Whipple's disease with endocarditis in a patient with dextrocardia.

SAGE Open Med Case Rep 2020 30;8:2050313X20936952. Epub 2020 Jun 30.

Department of Internal Medicine, Reading Hospital-Tower Health System, PA, USA.

We report a case of an elderly Caucasian male with past medical history of dextrocardia with situs inversus totalis, polymyalgia rheumatica, history of cryptogenic stroke, and severe mitral regurgitation with mitral valve prolapse, who presented with acute heart failure symptoms, including severe dyspnea on exertion and worsening lower extremity edema in the setting of immunosuppression with steroids for a year-old diagnosis of polymyalgia rheumatica. One month prior to this presentation, the patient suffered a transient ischemic attack and during the workup, his transthoracic echocardiography showed myxomatous degeneration of posterior mitral leaflet, partially flail, with severe mitral regurgitation, which required mitral valve replacement. Genome sequencing of mitral valve anterior leaflet pathology detected as a causal agent of culture-negative endocarditis. Read More

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http://dx.doi.org/10.1177/2050313X20936952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328352PMC

Long-term results of the edge-to-edge repair for failed mitral valve repair as a bailout option.

Gen Thorac Cardiovasc Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiovascular Surgery, Fuwai Hospital, Chinese Academy of Medical Science, No. 167, North Lishi Road, Xicheng District, Beijing, 100037, China.

Objective: We evaluate the long-term clinical and echocardiographic outcomes of edge-to-edge (E2E) repair combined with mitral annuloplasty in our institute with degenerative mitral regurgitation (MR) up to 10 years.

Methods: Twenty-six consecutive patients undergoing E2E mitral repair after failure of other conventional mitral repair technique. There were 16 (61. Read More

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http://dx.doi.org/10.1007/s11748-020-01433-zDOI Listing

[Minimally Invasive Mitral Valve Repair for Barlow's Disease;Stepwise Approach to the Complex Repair].

Authors:
Taichi Sakaguchi

Kyobu Geka 2020 Jul;73(7):529-537

Department of Cardiovascular Surgery, Hyogo College of Medicine, Nishinomiya, Japan.

Backgrounds: Mitral regurgitation (MR) in Barlow's disease is complicated because of its mixed pathophysiology, leaflet billowing with/without organic prolapse, and abnormal annular dynamics that causes functional prolapse. Complex repair techniques, including aggressive leaflet resection and implantation of multiple neochords, are conventionally performed;nevertheless, these are technically demanding, especially when performed using a minimally invasive approach. We aimed to standardize the repair technique for Barlow's disease and developed stepwise repair techniques. Read More

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[Tips for Use of Chordal Guide System for Easy Adjustment of Appropriate Artificial Chordae Length in Patients Undergoing Minimally Invasive Mitral Valve Repair].

Kyobu Geka 2020 Jul;73(7):517-522

Department of Cardiovascular Surgery, Osaka General Medical Center, Osaka, Japan.

Objectives: In patients who require minimally invasive mitral valve repair (MICS-mitral), it is difficult to determine the appropriate length of artificial chordae, position, and number of artificial chordae. The Memo 3D Rechord, a complete prosthetic ring associated with a temporary chordal guide system comprised of yellow loops that function as a reference guide for automatically determining the height of neo-chordae. We sought to evaluate our tips for use of this system. Read More

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Defining the left ventricular base in mitral valve prolapse: impact on systolic function and regurgitation.

Int J Cardiovasc Imaging 2020 Jul 6. Epub 2020 Jul 6.

Department of Cardiovascular Medicine, Morristown Medical Center, Gagnon Administration, Meade B, Morristown Medical Center, 100 Madison Ave, Morristown, NJ, 07960, USA.

In bileaflet mitral valve prolapse (BMVP) systolic leaflet displacement creates a pocket of blood on the left ventricular (LV) side of the leaflets, but on the atrial side of the annulus. This blood is excluded from the LV end-systolic volume if the mitral valve annulus is used to determine the most basal extent of the LV. The purpose of this study is to describe the quantitative implications of defining the LV base on mitral regurgitant severity and LV systolic function in BMVP. Read More

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http://dx.doi.org/10.1007/s10554-020-01927-0DOI Listing

Three patients with glucose-6 phosphatase catalytic subunit 3 deficiency.

J Pediatr Endocrinol Metab 2020 Jul 5. Epub 2020 Jul 5.

Department of Pediatrics, Division of Pediatric Immunology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Objectives Severe congenital neutropenia (SCN) is a primary immunodeficiency (PID) characterized by persistent severe neutropenia, recurrent infections, and oral aphthous lesions. Severe congenital neutropenia is caused by various genetic defects such as ELANE, GFI, HAX-1, JAGN1, SRP54, and glucose-6 phosphatase catalytic subunit 3 (G6PC3) deficiency. Clinical features of the patients with G6PC3 deficiency vary from neutropenia to several systemic features in addition to developmental delay. Read More

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http://dx.doi.org/10.1515/jpem-2019-0541DOI Listing

Extremely elevated serum alkaline phosphatase level upon treatment with teriparatide: a case report.

J Med Case Rep 2020 Jul 3;14(1):87. Epub 2020 Jul 3.

Rheumatology Research Center, Tehran University of Medical Sciences (TUMS), PO-Box: 1411713137, Tehran, Iran.

Background: Teriparatide is a homolog of human parathyroid hormone (1-34), which is approved for the treatment of postmenopausal and glucocorticoid-induced osteoporosis. Several minor and transient side effects have been reported for teriparatide. However, controversial findings showed an increased risk of more significant adverse effects, including osteosarcoma in humans, although this finding has been demonstrated primarily in murine models. Read More

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http://dx.doi.org/10.1186/s13256-020-02416-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333273PMC

Classification of heart sound signals using a novel deep WaveNet model.

Comput Methods Programs Biomed 2020 Jun 12;196:105604. Epub 2020 Jun 12.

School of Engineering, Ngee Ann Polytechnic, 535 Clementi Road, Singapore 599489, Singapore; International Research Organization for Advanced Science and Technology (IROAST), Kumamoto University, Kumamoto, Japan; Department Bioinformatics and Medical Engineering, Asia University, Taiwan. Electronic address:

Background And Objectives: The high mortality rate and increasing prevalence of heart valve diseases globally warrant the need for rapid and accurate diagnosis of such diseases. Phonocardiogram (PCG) signals are used in this study due to the low cost of obtaining the signals. This study classifies five types of heart sounds, namely normal, aortic stenosis, mitral valve prolapse, mitral stenosis, and mitral regurgitation. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105604DOI Listing

Safety and outcomes of combined liver transplantation and cardiac surgery in cirrhosis.

Ann Thorac Surg 2020 Jun 22. Epub 2020 Jun 22.

Departments of Gastroenterology/Transplant Hepatology, Cleveland Clinic, Ohio. Electronic address:

Background: Decompensation of the liver function after cardiac surgery in patients with cirrhosis has resulted high morbidity and mortality. A treatment strategy, of which there is a scarcity of data in the literature, encompasses combined liver transplant (LT) and cardiac surgery.

Methods: We performed a retrospective analysis of prospectively collected data on 15 patients who underwent combined LT and cardiac surgery between 2005 to 2017 at our institution. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.04.135DOI Listing

Mitral Annular Calcification In Stage 5 Chronic Kidney Disease On Dialysis Therapy.

J Ayub Med Coll Abbottabad 2020 Apr- Jun;32(2):179-183

Al-Aleem Medical College, Lahore, Pakistan.

Background: Mitral Annular Calcification (MAC) is a degenerative process involving the mitral valve and is a marker of advanced cardiovascular disease. Prevalence in the general population is upto 10% and increases in advanced age, diabetes mellitus, chronic kidney disease (CKD), end stage renal disease (upto 40%) and mitral valve prolapse.The aims of this study were to assess the prevalence of MAC in CKD5D patients and correlate with patients' characteristics. Read More

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Correction of bileaflet mitral valve prolapse via reduction of posterior leaflet height.

Ann Thorac Surg 2020 Jun 19. Epub 2020 Jun 19.

Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada. Electronic address:

Mitral regurgitation due to bileaflet prolapse can be corrected with height reduction of the posterior leaflet via detachment at its base, division of accompanying secondary chordae, and leaflet-annular re-approximation. This technique lowers the posterior leaflet height by approximately 1.5 cm, thereby displacing the line of coaptation posteriorly to achieve symmetry without the need for additional artificial chordae. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.04.131DOI Listing

New synthetic mitral valve model for human prolapsed mitral valve reconstructive surgery for training.

J Med Eng Technol 2020 Apr;44(3):133-138

The Heart Valve Performance Laboratory, School of Engineering, Faculty of Applied Science, University of British Columbia, Kelowna, BC, Canada.

The training process of young surgeons is highly desirable in order for them to gain an understanding of the quality of care and patient safety required during cardiac surgeries, however, it may take a few years of practice in order for them to properly develop these skills. Artificial life-like platforms and models are extremely recommended for teaching hands-on and real-world practice in both junior and even experienced medical professionals and surgeons. Suitable and accessible training tools are of significant importance for simulating a particular surgery in order to provide practice opportunities for a specific surgical procedure. Read More

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http://dx.doi.org/10.1080/03091902.2020.1753837DOI Listing

A Meta-analysis and Systematic Review of Valvular Heart Disease in Systemic Lupus Erythematosus and Its Association With Antiphospholipid Antibodies.

J Clin Rheumatol 2020 Jun 17. Epub 2020 Jun 17.

From the John H. Stroger Hospital of Cook County, Chicago.

Background: Valvular heart disease (VHD) is a known cardiac manifestation of systematic lupus erythematosus (SLE). This systematic review aims to pool data from studies to estimate the frequency of valvular lesions in SLE patients. It also aims to demonstrate the association between VHD in SLE and antiphospholipid antibodies positivity. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001464DOI Listing

A rare association of divided left atrium with mitral valve prolapse.

J Card Surg 2020 Jun 19. Epub 2020 Jun 19.

Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.

We hereby present a case of divided left atrium with mitral valve prolapse and discuss the hemodynamic consequences that ensue. This case demonstrates the utility of computed tomography angiography in identifying such associations. Read More

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http://dx.doi.org/10.1111/jocs.14743DOI Listing
June 2020
0.888 Impact Factor

Systolic Anterior Motion (SAM) Complicating Mitral Valve Repair: Current Concepts of Intraoperative and Postoperative Management.

Surg Technol Int 2020 Jun 16;37. Epub 2020 Jun 16.

Cardiovascular surgery, Universitá Campus Bio-Medico di Roma, Rome, Italy.

Mitral valve repair is the gold standard for treatment of degenerative mitral regurgitation, such as that caused by leaflet prolapse, flail or annular dilatation. A variety of surgical techniques allow surgeons to achieve a high rate of success with mitral valve repair, even in complex cases, and mitral valve repair is associated with better long-term outcomes than valve replacement. However, in the setting of mitral valve surgical repair, systolic anterior motion (SAM) is a complication that determines the dynamic anterior movement of the mitral valve towards the interventricular septum during systole, and creates a left ventricular outflow tract obstruction associated with residual mitral regurgitation. Read More

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Vascular Complications in the Era of Transcatheter Treatment of Adult Structural Heart Disease: A Single-Center Early Experience.

Vasc Endovascular Surg 2020 Aug 19;54(6):504-509. Epub 2020 Jun 19.

Division of Vascular & Endovascular Surgery, Department of Surgery, American University of Beirut Medical Centre, Beirut, Lebanon.

Transcatheter treatment is becoming the mainstay treatment for structural heart diseases (SHD) in prohibitive surgical risk patients. Recently with the encouraging results, it is being offered to regular risk patients. Peripheral vascular complications (VCs) are still inherent to these procedures due to the nature of this atherosclerotic high-risk group and the profile of the devices. Read More

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http://dx.doi.org/10.1177/1538574420934620DOI Listing

Double heterozygous variants in FBN1 and FBN2 in a Thai woman with Marfan and Beals syndromes.

Eur J Med Genet 2020 Jun 11;63(9):103982. Epub 2020 Jun 11.

Center of Excellence for Medical Genomics, Medical Genomics Cluster, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand; Excellence Center for Genomics and Precision Medicine, King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, 10330, Thailand.

A phenotype of an individual is resulted from an interaction among variants in several genes. Advanced molecular technologies allow us to identify more patients with mutations in more than one genes. Here, we studied a Thai woman with combined clinical features of Marfan (MFS) and Beals (BS) syndromes including frontal bossing, enophthalmos, myopia, the crumpled appearance to the top of the pinnae, midface hypoplasia, high arched palate, dermal stretch marks, aortic enlargement, mitral valve prolapse and regurgitation, aortic root dilatation, and progressive scoliosis. Read More

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http://dx.doi.org/10.1016/j.ejmg.2020.103982DOI Listing

Sneddon syndrome: under diagnosed disease, complex clinical manifestations and challenging diagnosis. A case-based review.

Rheumatol Int 2020 Jun 12. Epub 2020 Jun 12.

Department of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL, USA.

Herein, we report a case-based review of the Sneddon Syndrome (SS), a rare chronic condition which affects small to medium blood vessels. It is known by its skin presentation, livedo racemosa (LRC), and the relapsing cerebrovascular events. However, neither LRC nor cerebrovascular events are exclusive to SS. Read More

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http://dx.doi.org/10.1007/s00296-020-04625-1DOI Listing

Intrinsic cardiac elastography in patients with primary mitral regurgitation: predictive role after mitral valve repair.

Eur Heart J Cardiovasc Imaging 2020 Jun 12. Epub 2020 Jun 12.

Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Aims : Chronic volume-overload can impair systolic and diastolic myocardial properties. We tested the hypothesis that Intrinsic Cardiac Elastography may detect alterations in passive myocardial elasticity in patients with chronic severe mitral regurgitation (MR) and predict worsening left ventricular (LV) function after mitral valve repair (MVr).

Methods And Results : Comprehensive transthoracic echocardiography and cardiac elastography were performed in 80 patients with primary MR (prolapse and/or flail leaflets) of varying severity and compared with 40 normal subjects. Read More

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http://dx.doi.org/10.1093/ehjci/jeaa117DOI Listing

Arrhythmia insensitive rapid cardiac T1 mapping: comparison to modified look locker inversion recovery T1 mapping in mitral valve prolapse patients.

Int J Cardiovasc Imaging 2020 Jun 8. Epub 2020 Jun 8.

Austin Health, Heidelberg, Australia.

We compare a saturation recovery arrhythmia insensitive rapid (AIR) T1 mapping technique which is less sensitive to heart rate and requires shorter breath-holds to modified Look-Locker inversion recovery (MOLLI) T1 mapping in patients with mitral valve prolapse. 55 patients underwent AIR and MOLLI at 1.5 T. Read More

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http://dx.doi.org/10.1007/s10554-020-01910-9DOI Listing

Abnormal Papillary Muscle Signal on Cine MRI As a Typical Feature of Mitral Valve Prolapse.

Sci Rep 2020 Jun 8;10(1):9166. Epub 2020 Jun 8.

Division of Cardiology "Villa dei Fiori" Hospital, Acerra, Na, Italy.

Background: Mitral valve prolapse (MVP) is characterized by an abnormal movement of the valvular apparatus which may affect the papillary muscles (PMs) function and structure. Aim of the study was to investigate abnormal PM signal in MVP by using cardiac magnetic resonance imaging (MRI).

Methods And Results: We enrolled 47 consecutive patients with MVP evaluated by cardiac MRI. Read More

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http://dx.doi.org/10.1038/s41598-020-65983-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280529PMC

Long-term outcomes of ablation for ventricular arrhythmias in mitral valve prolapse.

J Interv Card Electrophysiol 2020 Jun 6. Epub 2020 Jun 6.

Division of Cardiovascular Medicine, University of California, San Francisco, San Francisco, CA, USA.

Purpose: Prior studies reporting efficacy of radiofrequency catheter ablation for complex ventricular ectopy in mitral valve prolapse (MVP) are limited by selective inclusion of bileaflet MVP, papillary muscle only ablation, or short-term follow-up. We sought to evaluate the long-term incidence of hemodynamically significant ventricular tachycardia (VT) or fibrillation (VF) in patients with MVP after initial ablation.

Methods: We studied consecutive patients with MVP undergoing ablation for complex ventricular ectopy between 2013 and 2017 at our institution. Read More

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http://dx.doi.org/10.1007/s10840-020-00775-1DOI Listing
June 2020
1.552 Impact Factor

Effect of a novel transcatheter edge-to-edge repair device on the three-dimensional geometry of mitral valve in degenerative mitral regurgitation.

Catheter Cardiovasc Interv 2020 Jun 4. Epub 2020 Jun 4.

Department of Cardiology, Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China.

Objectives: We sought to assess the acute intraprocedural effects of the ValveClamp system in DMR patients on the mitral valve (MV) three-dimensional (3D) geometry and the association of these effects with mitral regurgitation (MR) reduction.

Background: Few data are available about the specific impact of transcatheter edge-to-edge repair in patients with degenerative mitral regurgitation (DMR).

Methods: Thirty-five symptomatic patients (age 74. Read More

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http://dx.doi.org/10.1002/ccd.29002DOI Listing
June 2020
2.107 Impact Factor

TGFBR1 Rare Variant Associated With Thoracic Aortic Aneurysm, Double Chamber Left Ventricle, Coronary Anomaly, and Inducible Ventricular Tachycardia.

Circ Cardiovasc Imaging 2020 Jun;13(6):e010084

Division of Cardiology (K.B.-J., N.B.M., D.R., S.N., I.A.E., D.K., R.W.S., S.K.P.), Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston.

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http://dx.doi.org/10.1161/CIRCIMAGING.119.010084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285880PMC

Myocardial Infarction as the Initial Presentation for Fibromuscular Dysplasia.

Am J Med Case Rep 2020 12;8(7):166-172. Epub 2020 Apr 12.

Department of Internal Medicine, State University of New York: Downstate Medical Center, Brooklyn, New York, United States- 11203.

Background: Fibromuscular dysplasia (FMD) is a non-atherosclerotic disease that affects medium-sized arteries and results in stenosis, dissection, aneurysm or occlusion. It is most commonly reported in the renal and carotid arteries. Involvement of coronary arteries is quite rare and and leads to serious consequences. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252985PMC

Hybrid Positron Emission Tomography/Magnetic Resonance Imaging in Arrhythmic Mitral Valve Prolapse.

JAMA Cardiol 2020 May 27. Epub 2020 May 27.

The BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Importance: Myocardial replacement fibrosis has been reported to occur in one-third of patients with mitral valve prolapse (MVP) and significant mitral regurgitation (MR). However, it remains unknown whether there are detectable changes in myocardial metabolism suggestive of inflammation or ischemia that accompany the development of fibrosis.

Objectives: To characterize the burden and distribution of fluorine 18-labeled (18F) fluorodeoxyglucose (FDG) uptake and late gadolinium enhancement (LGE) in patients with degenerative MVP and ventricular ectopy. Read More

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http://dx.doi.org/10.1001/jamacardio.2020.1555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254450PMC

Association Between Malignant Mitral Valve Prolapse and Sudden Cardiac Death: A Review.

JAMA Cardiol 2020 May 27. Epub 2020 May 27.

Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St Luke's Medical Centers, University of Wisconsin School of Medicine and Public Health, Milwaukee.

Importance: Malignant arrhythmic mitral valve prolapse (MVP) phenotype poses a substantial risk of sudden cardiac death (SCD), and an estimated 26 000 individuals in the United States are at risk of SCD per year. Thus, identifying risk-stratification strategies for SCD is imperative.

Observations: Patients with MVP have a heterogenous clinical spectrum, ranging from a benign course to a devastating complication such as SCD. Read More

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http://dx.doi.org/10.1001/jamacardio.2020.1412DOI Listing

Oral batyl alcohol supplementation rescues decreased cardiac conduction in ether phospholipid-deficient mice.

J Inherit Metab Dis 2020 May 22. Epub 2020 May 22.

Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Vienna, Austria.

Plasmalogens (Pls) are a class of membrane phospholipids which serve a number of essential biological functions. Deficiency of Pls is associated with common disorders such as Alzheimer's disease or ischemic heart disease. A complete lack of Pls due to genetically determined defective biosynthesis gives rise to rhizomelic chondrodysplasia punctata (RCDP), characterized by a number of severe disabling pathologic features and death in early childhood. Read More

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http://dx.doi.org/10.1002/jimd.12264DOI Listing

Understanding Non-P2 Mitral Regurgitation Using Real-Time Three-Dimensional Transesophageal Echocardiography: Characterization and Factors Leading to Underestimation.

J Am Soc Echocardiogr 2020 Jul 6;33(7):826-837. Epub 2020 May 6.

Laboratory of Echocardiography, Cardiovascular Division, Yale New Haven Hospital, Yale University, New Haven, Connecticut. Electronic address:

Background: P2 prolapse is a common cause of degenerative mitral regurgitation (MR); echocardiographic characteristics of non-P2 prolapse are less known. Because of the eccentric nature of degenerative MR jets, the evaluation of MR severity is challenging. The aim of this study was to test the hypotheses that (1) the percentage of severe MR determined by transthoracic echocardiography (TTE) would be lower compared with that determined by transesophageal echocardiography (TEE) in patients with non-P2 prolapse and also in a subgroup with "horizontal MR" (a horizontal jet seen on TTE that hugs the leaflets without reaching the atrial wall, particularly found in non-P2 prolapse) and (2) the directions of MR jets between TTE and real-time (RT) three-dimensional (3D) TEE would be discordant. Read More

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http://dx.doi.org/10.1016/j.echo.2020.03.011DOI Listing

Stepwise mitral valve repair for Barlow's disease via a minimally invasive approach.

J Card Surg 2020 Jul 7;35(7):1471-1476. Epub 2020 May 7.

Department of Cardiovascular Surgery, The Sakakibara Heart Institute of Okayama, Okayama, Japan.

Background And Aim: Mitral regurgitation (MR) in Barlow's disease is complicated because of its mixed pathophysiology, leaflet billowing with or without organic prolapse, and abnormal annular dynamics that cause functional prolapse. Complex repair techniques, including aggressive leaflet resection and implantation of multiple artificial chordae, are conventionally performed; nevertheless, these are technically demanding, especially when performed using a minimally invasive approach. We aimed to standardize the repair technique for Barlow's disease and developed stepwise repair techniques. Read More

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http://dx.doi.org/10.1111/jocs.14615DOI Listing

Additional cleft mitral valve diagnosed by a combination of 2-D and 3-D echocardiography using transesophageal echocardiography during mitral valve prolapse: a case report.

JA Clin Rep 2020 May 1;6(1):30. Epub 2020 May 1.

Department of Anesthesia, New Heart Watanabe Institute, Hamadayama 3-19-11, Suginami-ku, Tokyo, 168-0065, Japan.

Background: A mitral cleft may be an important etiological factor for significant mitral regurgitation. We diagnose an additional cleft mitral valve by a combination of 2-dimensional (2-D) and 3-dimensional (3-D) echocardiography.

Case Presentation: We describe the case of a severe mitral regurgitation due to posterior leaflet prolapse (P2). Read More

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http://dx.doi.org/10.1186/s40981-020-00337-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195506PMC

A New Role for the Aldosterone/Mineralocorticoid Receptor Pathway in the Development of Mitral Valve Prolapse.

Circ Res 2020 Apr 24. Epub 2020 Apr 24.

Instituto de Investigación Sanitaria de Navarra.

Mitral valve prolapse (MVP) is one of the most common valvular disorders. However, the molecular and cellular mechanisms involved in fibromyxomatous changes in the mitral leaflet tissue have not been elucidated. Aldosterone (Aldo) promotes fibrosis in myocardium and mineralocorticoid receptor antagonists (MRAs) improve cardiac function by decreasing cardiac fibrosis. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.119.316427DOI Listing

Transthoracic echocardiography features of adult-type anomalous left coronary artery from the pulmonary artery before and after surgery: highlights from observational study in a single center of China.

Int J Cardiovasc Imaging 2020 Apr 23. Epub 2020 Apr 23.

Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Er Road, Guangzhou, 510100, China.

To review the imaging characteristics of adult-type anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) and evaluate the post-operative echocardiographic features. The transthoracic echocardiography (TTE) records and invasive coronary angiography (ICA), coronary computed tomography angiography (CTA) or operative findings of thirty adult patients with final diagnosis of ALCAPA were reviewed at our center. The diagnostic reliability of TTE was determined by comparing its results with that of ICA/CTA, and the echocardiographic features of the patients during early visit and post-operative follow-up were summarized. Read More

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http://dx.doi.org/10.1007/s10554-020-01857-xDOI Listing

Features of heritable disorders of connective tissue in children with acute rheumatic fever and rheumatic heart disease.

Authors:
Oksana Boyarchuk

Reumatologia 2020 28;58(1):21-25. Epub 2020 Feb 28.

Department of Children's Diseases and Paediatric Surgery, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.

Objectives: Heritable disorders of connective tissue (HDCT) are associated with morphological and functional disorders of different organs and systems. The aim of our study was to determine the clinical signs of heritable disorders of connective tissue and oxyproline levels in children with acute rheumatic fever (ARF) and rheumatic heart disease (RHD).

Material And Methods: A total of 155 patients aged 4 to 17 years participated in the study: 23 with ARF, 78 with RHD, and 54 healthy patients with a history of ARF. Read More

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http://dx.doi.org/10.5114/reum.2020.93509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174797PMC
February 2020

Nonbacterial Thrombotic Endocarditis and Widespread Skin Necrosis in Newly Diagnosed Lung Adenocarcinoma.

Case Rep Oncol 2020 Jan-Apr;13(1):239-244. Epub 2020 Mar 19.

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.

Nonbacterial thrombotic endocarditis (NBTE) is a rare entity most commonly diagnosed postmortem with rates in autopsy series ranging from 0.9 to 1.6%. Read More

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http://dx.doi.org/10.1159/000506453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154248PMC

Quantitative Proteomics of Human Heart Samples Collected Reveal the Remodeled Protein Landscape of Dilated Left Atrium Without Atrial Fibrillation.

Mol Cell Proteomics 2020 Jul 14;19(7):1132-1144. Epub 2020 Apr 14.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark

Genetic and genomic research has greatly advanced our understanding of heart disease. Yet, comprehensive, in-depth, quantitative maps of protein expression in hearts of living humans are still lacking. Using samples obtained during valve replacement surgery in patients with mitral valve prolapse (MVP), we set out to define inter-chamber differences, the intersect of proteomic data with genetic or genomic datasets, and the impact of left atrial dilation on the proteome of patients with no history of atrial fibrillation (AF). Read More

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http://dx.doi.org/10.1074/mcp.RA119.001878DOI Listing

Identification of known and unknown genes associated with mitral valve prolapse using an exome slice methodology.

J Med Genet 2020 Apr 10. Epub 2020 Apr 10.

Cardiology, Leiden University Medical Center, Leiden, Zuid-Holland, The Netherlands

Purpose: Although a familial distribution has been documented, the genetic aetiology of mitral valve prolapse (MVP) is largely unknown, with only four genes identified so far: , , and . The aim of this study was to evaluate the genetic yield in known causative genes and to identify possible novel genes associated with MVP using a heart gene panel based on exome sequencing.

Methods: Patients with MVP were referred for genetic counselling when a positive family history for MVP was reported and/or Barlow's disease was diagnosed. Read More

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http://dx.doi.org/10.1136/jmedgenet-2019-106715DOI Listing

A rare case of isolated mitral valve endocarditis by Gemella sanguinis: Case report and review of the literature.

Int J Surg Case Rep 2020 7;69:51-54. Epub 2020 Mar 7.

Department of Cardiothoracic Surgery, New York - Presbyterian Hospital, Weill Cornell Medical Center, New York, NY 10065, United States.

Introduction: Gemella sanguinis is an extremely rare cause of infectious endocarditis, with only 12 cases previously reported in the literature. Here we report the third known case of isolated mitral valve endocarditis secondary to G. sanguinis. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139129PMC

Long-term outcomes of surgical procedures for Marfan syndrome: aortic dissection versus aneurysm.

J Thorac Dis 2020 Mar;12(3):249-257

Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.

Background: Multiple of subsequent procedures may necessary in Marfan syndrome (MFS) patients after initial surgery. The aim of this study was to investigate the full spectrum of secondary distal vascular or valvular interventions encountered after initial surgery.

Methods: Retrospective analysis of 201 consecutive MFS patients between January 2000 and March 2019 who underwent 274 distal aortic reinterventions and 5 mitral valve replacements. Read More

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http://dx.doi.org/10.21037/jtd.2020.01.72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139013PMC

Dynamic computed tomographic assessment of the mitral annulus in patients with and without mitral prolapse.

J Cardiovasc Comput Tomogr 2020 Feb 27. Epub 2020 Feb 27.

Department of Radiology, 200 First Street SW, Mayo Clinic, Rochester, MN, 55905, USA. Electronic address:

Objectives: To obtain 3D CT measurements of mitral annulus throughout cardiac cycle using prototype mitral modeling software, assess interobserver agreement, and compare among patients with mitral prolapse (MP) and control group.

Background: Pre-procedural imaging is critical for planning of transcatheter mitral valve (MV) replacement. However, there is limited data regarding reliable CT-based measurements to accurately characterize the dynamic geometry of the mitral annulus in patients with MV disease. Read More

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http://dx.doi.org/10.1016/j.jcct.2020.02.005DOI Listing
February 2020

Butterfly technique in mitral valve repair.

Authors:
Tohru Asai

Asian Cardiovasc Thorac Ann 2020 Apr 6:218492320916298. Epub 2020 Apr 6.

Department of Cardiovascular Surgery, Juntendo University, Tokyo, Japan.

Degenerative mitral regurgitation due to posterior leaflet prolapse is often associated with tissue redundancy in the leaflet height and free margin of the prolapsing segment. The butterfly technique has been introduced for focal resection to precisely control the leaflet height without annular plication. This technique is indicated for a high prolapsing leaflet, greater than 20 mm. Read More

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http://dx.doi.org/10.1177/0218492320916298DOI Listing

Mitral valve prolapse and partial saw-tooth cardiomyopathy: an unusual combination.

J Cardiovasc Med (Hagerstown) 2020 Apr 3. Epub 2020 Apr 3.

Fondazione 'G.Monasterio' CNR - Regione Toscana.

: We present a case of pediatric mitral valve prolapse associated with an uncommon form of hypertrophic cardiomyopathy in a 16-year-old asymptomatic girl. Echocardiographic examination had shown a hyperechoic mass close to the papillary muscles. There was mitral valve prolapse with moderate regurgitation. Read More

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http://dx.doi.org/10.2459/JCM.0000000000000967DOI Listing

Marfan syndrome and related connective tissue disorders in the current era in Switzerland in 103 patients: medical and surgical management and impact of genetic testing.

Swiss Med Wkly 2020 Mar 3;150:w20189. Epub 2020 Apr 3.

Cardiovascular Centre, Klinik Im Park, Zurich, Switzerland.

Introduction: Marfan syndrome (MFS) and related connective tissue disorders (CTDs) are increasingly recognised. Genetic testing has greatly improved the diagnostic outcome/power over the last two decades. In this study we describe a multicentre cohort of adults with MFS and related CTDs, with a particular focus on results from genetic testing. Read More

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http://dx.doi.org/10.4414/smw.2020.20189DOI Listing

Preoperative determination of artificial chordae tendineae length by transoesophageal echocardiography in totally endoscopic mitral valve repair.

Interact Cardiovasc Thorac Surg 2020 Jul;31(1):20-27

Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA.

Objectives: Artificial chordae tendineae are widely used for surgical repair in patients with mitral regurgitation due to floppy mitral valve/mitral valve prolapse. Expanded polytetrafluoroethylene has been used to construct these artificial chordae; however, the determination of the optimal length of the chordae prior to surgery has been an issue. For this reason, such a method was developed and the results of its use are presented. Read More

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http://dx.doi.org/10.1093/icvts/ivaa046DOI Listing

Characteristic Histopathological Findings and Cardiac Arrest Rhythm in Isolated Mitral Valve Prolapse and Sudden Cardiac Death.

J Am Heart Assoc 2020 Apr 1;9(7):e015587. Epub 2020 Apr 1.

Department of Cardiology Austin Health and University of Melbourne Melbourne Victoria Australia.

Background The association between mitral valve prolapse (MVP) and sudden death remains controversial. We aimed to describe histopathological changes in individuals with autopsy-determined isolated MVP (iMVP) and sudden death and document cardiac arrest rhythm. Methods and Results The Australian National Coronial Information System database was used to identify cases of iMVP between 2000 and 2018. Read More

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http://dx.doi.org/10.1161/JAHA.119.015587DOI Listing

Respiratory Sinus Arrhythmia as an Index of Cardiac Vagal Control in Mitral Valve Prolapse.

Physiol Res 2020 03;69(Suppl 1):S161-S167

Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University Bratislava, Martin, Slovak

Respiratory sinus arrhythmia (RSA), i.e. heart rate (HR) variations during inspiration and expiration, is considered as a noninvasive index of cardiac vagal control. Read More

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http://dx.doi.org/10.33549/physiolres.934402DOI Listing

Mitral annulus morphometry in degenerative mitral regurgitation phenotypes.

Echocardiography 2020 Apr 30;37(4):612-619. Epub 2020 Mar 30.

Fondazione Cardiocentro Ticino, Lugano, Switzerland.

Objectives: Degenerative mitral regurgitation (DMR) is classified into different phenotypes based on the extent of leaflet degeneration. Our aim is to demonstrate that phenotype complexity predicts the extent of structural abnormalities of mitral annulus (MA).

Methods And Results: Seventy-five patients with DMR and severe valve regurgitation and 23 patients with normal mitral valve were studied using 3D transesophageal echocardiography. Read More

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http://dx.doi.org/10.1111/echo.14647DOI Listing

Recent Modifications of the Nuss Procedure: The Pursuit of Safety During the Minimally Invasive Repair of Pectus Excavatum.

Ann Surg 2020 Mar 27. Epub 2020 Mar 27.

Children's Hospital of The King's Daughters, Norfolk, VA.

Objective: To review standardized Nuss correction of pectus excavatum and vacuum bell treatment over the last 10 years.

Summary Of Background Data: In 2010, we reported 21 years of the Nuss procedure in 1215 patients.

Methods: Over the last 10 years, 2008-2018, we evaluated 1885 pectus excavatum patients. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003877DOI Listing