Search our Database of Scientific Publications and Authors

I’m looking for a

    6650 results match your criteria Mitral Valve Prolapse

    1 OF 133

    Triangular resection versus neochordal replacement for posterior leaflet prolapse: a morphological assessment.
    Interact Cardiovasc Thorac Surg 2017 Aug 14. Epub 2017 Aug 14.
    Department of Cardiovascular Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
    Objectives: To evaluate the morphological reconstruction as assessed by 3D transoesophageal echocardiography after triangular resection and neochordal replacement in the treatment of posterior leaflet prolapse.

    Methods: We retrospectively selected 46 patients with isolated posterior leaflet prolapse who were undergoing mitral valve repair using triangular resection ( n  = 20) and neochordal replacement ( n  = 26) techniques. Sixty patients without valvular heart disease were also included as the control group. Read More

    Autograft Valve-Sparing Root Replacement for Late Ross Failure during Quadruple-Valve Surgery.
    Ann Thorac Cardiovasc Surg 2017 Oct 17. Epub 2017 Oct 17.
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
    Approximately 25% of patients require reoperation within 15 yrs of a Ross procedure. Increasing experience with valve-sparing root replacement (VSRR) has led some surgeons to spare the autograft valve. Here, we demonstrate that all valves can be surgically repaired or replaced safely during autograft VSRR. Read More

    Percutaneous repair of severe mitral valve regurgitation secondary to chordae rupture in octogenarians using MitraClip.
    J Interv Cardiol 2017 Oct 12. Epub 2017 Oct 12.
    Department of Internal Medicine III, Division of Cardiology, University of Heidelberg, Heidelberg, Germany.
    Objectives: The aim of this study was to assess feasibility and clinical effectiveness of the MitraClip device in octogenarians suffering from severe mitral valve regurgitation due to chordae rupture.

    Background: The MitraClip procedure is a suitable technique in high-risk surgical patients to achieve safe and effective percutaneous repair of mitral valve regurgitation. Octogenarians show cumulative risk and social aspects hindering mitral valve surgery. Read More

    New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study.
    Eur Heart J 2017 Sep 6. Epub 2017 Sep 6.
    l'institut du thorax, INSERM, CNRS, UNIV Nantes, Nantes, France.
    Aims: Filamin-A (FLNA) was identified as the first gene of non-syndromic mitral valve dystrophy (FLNA-MVD). We aimed to assess the phenotype of FLNA-MVD and its impact on prognosis.

    Methods And Results: We investigated the disease in 246 subjects (72 mutated) from four FLNA-MVD families harbouring three different FLNA mutations. Read More

    Perioperative management of a patient with glanzmann's thrombasthenia for mitral valve repair under cardiopulmonary bypass.
    Ann Card Anaesth 2017 Oct-Dec;20(4):468-471
    Department of Anesthesiology, Sri Jayadeva Institute of Cardiovascular Sciences, Bengaluru, Karnataka, India.
    A 30-year-old male patient presented with Glanzmann's thrombasthenia and mitral valve prolapse. He was in acute decompensated congestive heart failure due to severe mitral and tricuspid regurgitation. After his cardiac failure had been stabilized, the patient was subjected to mitral and tricuspid valve repair. Read More

    Heritability of Mitral Regurgitation: Observations From the Framingham Heart Study and Swedish Population.
    Circ Cardiovasc Genet 2017 Oct;10(5)
    From the Boston University's and National Heart, Lung and Blood Institute's Framingham Heart Study, MA (F.N.D., B.T.L., E.W.O., P.S., E.J.B., R.S.V.); Cardiovascular Division, Department of Medicine, University of California San Francisco (F.N.D.); Center for Primary Health Care Research, Lund University, Malmö, Sweden (X.L., B.Z., K.S.); Department of Biostatistics (S.L., Q.Y., V.X.), Department of Epidemiology (V.X., E.J.B., R.S.V.), and Cardiology and Preventive Medicine Sections, Department of Medicine (E.J.B., R.S.V.), Boston University School of Medicine, MA; Department of Cardiology, Clinical Sciences, Lund University, Sweden (A.M., P.A., J.G.S.); and Skåne University Hospital, Lund, Sweden (A.M., P.A., J.G.S.).
    Background: Familial aggregation has been described for primary mitral regurgitation (MR) caused by mitral valve prolapse. We hypothesized that heritability of MR exists across different MR subtypes including nonprimary MR.

    Methods And Results: Study participants were FHS (Framingham Heart Study) Generation 3 (Gen 3) and Gen 2 cohort participants and all adult Swedish siblings born after 1932 identified in 1997 and followed through 2010. Read More

    Atrioventricular valve regurgitation in patients undergoing total cavopulmonary connection: Impact of valve morphology and underlying mechanisms on survival and reintervention.
    J Thorac Cardiovasc Surg 2017 Sep 15. Epub 2017 Sep 15.
    Department of Cardiovascular Surgery, German Heart Center Munich at the Technical University of Munich, Munich, Germany; German Centre for Cardiovascular Research, Munich, Germany.
    Objective: The study objective was to determine the mechanisms of atrioventricular valve regurgitation in single-ventricle physiology and their influence on outcomes after total cavopulmonary connection.

    Methods: Among 460 patients who underwent a total cavopulmonary connection, 101 (22%) had atrioventricular valve surgery before or coincident with total cavopulmonary connection.

    Results: Atrioventricular valve morphology showed 2 separated in 33 patients, mitral in 11 patients, tricuspid in 41 patients, and common in 16 patients. Read More

    Isolated aortic root dilation in homocystinuria.
    J Inherit Metab Dis 2017 Oct 4. Epub 2017 Oct 4.
    Charles Dent Metabolic Unit, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
    Background: Vascular complications in homocystinuria have been known for many years, but there have been no reports to date on involvement of the ascending aorta.

    Methods: We conducted a cross-sectional study of patients with homocystinuria, known to a single metabolic centre, and evaluated in 2016 with a transthoracic echocardiogram. Aortic root dilation was defined as Z-score ≥ 2. Read More

    Beating heart mitral valve repair with neochordae implantation: real-time monitoring of haemodynamic recovery.
    Eur J Cardiothorac Surg 2017 Jul 13. Epub 2017 Jul 13.
    Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.
    Transapical off-pump mitral valve repair with neochord implantation has been approved for patients presenting with severe mitral regurgitation due to leaflet prolapse or flail. The procedure is performed under real-time 2D and 3D transoesophageal echocardiography for both implantation and neochordae tension adjustment allowing real-time monitoring of haemodynamic recovery. Read More

    Systematic review and meta-analysis of chordal replacement versus leaflet resection for posterior mitral leaflet prolapse.
    J Thorac Cardiovasc Surg 2017 Aug 24. Epub 2017 Aug 24.
    Department of Surgery, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. Electronic address:
    Objectives: To compare outcomes of chordal replacement versus leaflet resection techniques for repair of isolated posterior mitral leaflet prolapse.

    Methods: We searched MEDLINE and EMBASE databases for studies that compared chordal replacement ("neo-chord" group) versus leaflet resection ("resection" group) techniques for the treatment of posterior mitral leaflet prolapse. Data were extracted by 2 independent investigators and subjected to a meta-analysis using a random-effects model. Read More

    Cardiovascular Benefits of Moderate Exercise Training in Marfan Syndrome: Insights From an Animal Model.
    J Am Heart Assoc 2017 Sep 25;6(9). Epub 2017 Sep 25.
    Departament de Biomedicina, Facultat de Medicina, Universitat de Barcelona, Spain
    Background: Marfan syndrome (MF) leads to aortic root dilatation and a predisposition to aortic dissection, mitral valve prolapse, and primary and secondary cardiomyopathy. Overall, regular physical exercise is recommended for a healthy lifestyle, but dynamic sports are strongly discouraged in MF patients. Nonetheless, evidence supporting this recommendation is lacking. Read More

    Surgical Outcomes of Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery in Children: An Echocardiography Follow-up.
    Chin Med J (Engl) 2017 Oct;130(19):2333-2338
    Heart Center, Children's Hospital of Fudan University, Shanghai 201102, China.
    Background: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare but potentially life-threatening congenital heart defect. A retrospective analysis was carried out to elucidate the surgical outcomes of ALCAPA in infants and children using follow-up echocardiography.

    Methods: From September 2008 to March 2017, 26 children diagnosed with ALCAPA underwent left coronary re-implantation. Read More

    Neochordoplasty versus leaflet resection for ruptured mitral chordae treatment: Virtual mitral valve repair.
    Comput Biol Med 2017 Nov 13;90:50-58. Epub 2017 Sep 13.
    Division of Cardiovascular Medicine, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Biomechatronic Engineering, Sungkyunkwan University, Suwon, Gyeonggi, South Korea. Electronic address:
    Degenerative mitral valve (MV) disease involving mitral prolapse is one of the most prevalent MV pathologies. Quadrangular leaflet resection and neochordoplasty demonstrate excellent clinical outcomes for the treatment of posterior leaflet prolapse. We evaluated the functional and biomechanical characteristics of a virtual pathologic MV model suffering from chordal rupture, performed virtual neochordoplasty and quadrangular leaflet resection, and compared the two post-repair MV functions. Read More

    Low body mass index correlates with low left ventricular mass index in patients with severe anorexia nervosa.
    Heart Vessels 2017 Sep 8. Epub 2017 Sep 8.
    Department of Psychosomatic Medicine, Liaison Center, St. Luke's International Hospital, Tokyo, Japan.
    The patients with anorexia nervosa (AN) are known to be associated with high mortality, but the actual causes of death are still undefined. We tested the hypothesis that AN patients had cardiac disorders, including left ventricular (LV) dysfunction and LV atrophy. This study is a cross-sectional study at St. Read More

    Infectious Endocarditis from Enterococcus faecalis Associated with Tubular Adenoma of the Sigmoid Colon.
    Case Rep Infect Dis 2017 7;2017:3095031. Epub 2017 Aug 7.
    Centro de Ensino Superior de Maringá (UNICESUMAR), Avenida Guedner, 1610 Jardim Aclimação, 87050-390 Maringá, PR, Brazil.
    Introduction: Enterococcus faecalis (E. faecalis), a constituent of the gut microbiota, can be associated with both colonic lesions and endocarditis. Since this microorganism is one of the endocarditis etiological agents, there is a need for greater study in regard to the association with endocarditis and colonic lesions. Read More

    A rare complication of mechanical aortic valve replacement: Separation in the region of the mitral-aortic intervalvular fibrosa.
    Echocardiography 2017 Aug;34(8):1232-1233
    Department of Cardiology, Kartal Kosuyolu Heart & Research Hospital, Istanbul, Turkey.
    A 28-year-old man was admitted to our emergency service with a shortness of breath and palpitation. On admission, his blood pressure was high and he was in hypertensive pulmonary edema. His physical examination showed rales in both lungs and pansystolic murmur at mitral focus. Read More

    Circulating exosome microRNA associated with heart failure secondary to myxomatous mitral valve disease in a naturally occurring canine model.
    J Extracell Vesicles 2017 12;6(1):1350088. Epub 2017 Jul 12.
    Department of Clinics Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, USA.
    Myxomatous mitral valve disease (MMVD) is functionally and histologically identical to mitral valve prolapse (MVP) in humans. Currently, there are no medical treatments that can delay the progression of this valvular disease or associated cardiac remodelling. Therefore, there is a need to understand the molecular pathology associated with MMVD and MVP better, and thus identify potential therapeutic targets. Read More

    The analysis of mitral annular disjunction detected by echocardiography and comparison with previously reported pathological data.
    J Echocardiogr 2017 Aug 10. Epub 2017 Aug 10.
    Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047, Japan.
    Background: Mitral annular disjunction is a structural abnormality of the mitral annulus fibrosus and is pathologically defined by a separation between the atrial wall-mitral valve junction and the left ventricular attachment. Mitral annular disjunction can cause hypermobility of the mitral valve apparatus and is often associated with mitral valve prolapse (MVP). The aim of this study was to investigate the frequency and characteristics of mitral annular disjunction in the patients referred to an echocardiography laboratory and to compare these with previously reported pathological data. Read More

    Whole Exome Sequencing Identify the 6q12-q16 Linkage Region and a Candidate Gene TTK for Pulmonary Nontuberculous Mycobacterial Disease.
    Am J Respir Crit Care Med 2017 Aug 4. Epub 2017 Aug 4.
    Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Baltimore, Maryland, United States ;
    Rationale: Pulmonary nontuberculous mycobacterial (PNTM) disease often affects white postmenopausal women, with a tall and lean body habitus and higher rates of scoliosis, pectus excavatum, mitral valve prolapse, and mutations in the CFTR gene. These clinical features and the familial clustering of the disease suggest an underlying genetic mechanism.

    Objectives: To map the genes associated with PNTM, whole-exome sequencing (WES) was conducted in 12 PNTM families and 57 sporadic cases recruited at the NIH Clinical Center during 2001-2013. Read More

    Left main coronary artery atresia in a child: a case report and review of the literature.
    Cardiol Young 2017 Nov 3;27(9):1841-1844. Epub 2017 Aug 3.
    Department of Pediatrics,Kurashiki Central Hospital,Kurashiki,Japan.
    Congenital atresia of the left coronary artery is a very rare condition. We report a case of a 13-year-old boy who was followed-up at our outpatient clinic from 6 months of age because of heart murmur. He had no symptoms for more than 10 years, and his left ventricular contraction was normal. Read More

    Should annuloplasty prosthesis be selected dependent on the location of prolapse in mitral valve repair for type II dysfunction?
    J Thorac Cardiovasc Surg 2017 Jul 4. Epub 2017 Jul 4.
    Department of Cardiac Surgery, National Cerebral and Cardiovascular Center, Osaka, Japan.
    Objective: This study explored the influence of prosthesis selection on long-term outcomes in patients who underwent mitral valve repair for mitral insufficiency (MI) due to type II dysfunction.

    Methods: We retrospectively reviewed 452 patients with MI who underwent mitral valve repair for type II dysfunction between 2001 and 2014. Of these, 167 patients (37%) presented with anterior leaflet prolapse (anterior group) and 285 (63%) presented with posterior prolapse (posterior group). Read More

    Impact of bileaflet mitral valve prolapse on quantification of mitral regurgitation with cardiac magnetic resonance: a single-center study.
    J Cardiovasc Magn Reson 2017 Jul 27;19(1):56. Epub 2017 Jul 27.
    Center for Cardiac Magnetic Resonance (CRMC), University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
    Background: To quantify mitral regurgitation (MR) with CMR, the regurgitant volume can be calculated as the difference between the left ventricular (LV) stroke volume (SV) measured with the Simpson's method and the reference SV, i.e. the right ventricular SV (RVSV) in patients without tricuspid regurgitation. Read More

    Matrix Metalloproteinase Polymorphisms in Patients with Floppy Mitral Valve/Mitral Valve Prolapse (FMV/MVP) and FMV/MVP Syndrome.
    Cardiology 2017 Jul 28;138(3):179-185. Epub 2017 Jul 28.
    Division of Cardiovascular Medicine, Department of Medicine, The Ohio State University, Columbus, OH, USA.
    Background: It has been suggested that collagen abnormalities of the mitral valve are present in patients with floppy mitral valve (FMV)/mitral valve prolapse (MVP). Genetic factors determining collagen synthesis and degradation have not been well defined in these patients. This study was undertaken to determine whether selective polymorphisms of matrix metalloproteinase-2 (MMP2) or transforming growth factor-β (TGFβ), with known or putative effects on collagen turnover, are more frequent in FMV/MVP. Read More

    Mitral Valve Repair: The French Correction Versus the American Correction.
    Surg Clin North Am 2017 Aug;97(4):867-888
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia, 1215 Lee Street, Box 800679, Charlottesville, VA 22908, USA.
    Degenerative mitral valve disease causing mitral regurgitation is the most common organic valve pathology and is classified based on leaflet motion. The "French correction" mitral valve repair method restores normal valvular anatomy with extensive leaflet resection, chordal manipulation, and rigid annuloplasty. The American correction attempts to restore normal valve function through minimal leaflet resection, flexible annuloplasty, and use of artificial chordae. Read More

    Effect of Recurrent Mitral Regurgitation After Mitral Valve Repair in Patients With Degenerative Mitral Regurgitation.
    Circ J 2017 Jul 20. Epub 2017 Jul 20.
    Department of Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine.
    Background: This study investigated the consequences of recurrent mitral regurgitation (MR) after mitral valve (MV) repair in patients with degenerative MR and risk factors for recurrence.Methods and Results:From January 1990 to December 2015, 792 patients underwent MV repair due to degenerative MR. Recurrent MR was defined as moderate-to-severe MR on follow-up echocardiography. Read More

    Marfan syndrome and cardiovascular complications: results of a family investigation.
    BMC Cardiovasc Disord 2017 Jul 19;17(1):193. Epub 2017 Jul 19.
    Department of Cardiology, Teaching Hospital Aristide Le Dantec, PO Box 6003, Dakar Etoile, Sénégal.
    Background: Cardiovascular complications in Marfan syndrome (MFS) make all its seriousness. Taking as a basis the Ghent criteria, we conducted a family screening from an index case. The objective was to describe the clinical characteristics of MFS anomalies and to detect cardiovascular complications in our patients. Read More

    Deletion of Fstl1 (Follistatin-Like 1) From the Endocardial/Endothelial Lineage Causes Mitral Valve Disease.
    Arterioscler Thromb Vasc Biol 2017 Sep 13;37(9):e116-e130. Epub 2017 Jul 13.
    From the Department of Medical Biology, Academic Medical Center, Amsterdam, The Netherlands (S.P., M.S., F.R., Q.D.G., J.M.R., M.J.B.v.d.H.); Cardiovascular Imaging Laboratory, Centro Nacional de Investigación Cardiovascular, Madrid, Spain (L.J.J.B., L.F.R.); and Intercellular Signaling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigación Cardiovascular, Madrid, Spain (J.-L.d.l.P.).
    Objective: Fstl1 (Follistatin-like 1) is a secreted protein that is expressed in the atrioventricular valves throughout embryonic development, postnatal maturation, and adulthood. In this study, we investigated the loss of Fstl1 in the endocardium/endothelium and their derived cells.

    Approach And Results: We conditionally ablated Fstl1 from the endocardial lineage using a transgenic Tie2-Cre mouse model. Read More

    An unusual presentation of ischaemic mitral regurgitation as P2 prolapse.
    Perfusion 2017 Jul 1:267659117720989. Epub 2017 Jul 1.
    2 Cardiothoracic Surgery, Imperial College Healthcare, Hammersmith Hospital, London, UK.
    A 54-year-old gentleman presented with pulmonary oedema secondary to anterolateral papillary muscle (PPM) rupture and acute mitral regurgitation subsequent to myocardial ischaemia (MI). Angiography revealed complete occlusion of the first obtuse marginal (OM1) branch of the circumflex coronary artery and a 70% occlusion of the left anterior descending (LAD) coronary artery. Operatively, unusual anatomy was noted; an accessory head was attached superiorly to the anterior lateral PPM. Read More

    Cardiovascular Histopathology of a 11-Year Old with Mucopolysaccharidosis VII Demonstrates Fibrosis, Macrophage Infiltration, and Arterial Luminal Stenosis.
    JIMD Rep 2017 Jul 13. Epub 2017 Jul 13.
    Department of Pediatrics, University of California, Irvine School of Medicine, Orange, CA, 92868, USA.
    Mucopolysaccharidosis type VII (MPS VII) is caused by β-glucuronidase deficiency, resulting in lysosomal accumulation of glycosaminoglycans (GAGs) and multisystemic disease. We present cardiovascular gross and histopathology findings from a 11-year-old MPS VII male, who expired after developing ventricular fibrillation following anesthesia induction. Gross anatomic observations were made at autopsy; postmortem formalin-fixed paraffin-embedded samples of the carotid artery, aorta, myocardium, and valves were sectioned and stained with hematoxylin-eosin, Verhoeff-Van Gieson, CD68, and trichrome stains. Read More

    The 'respect rather than resect' principle in mitral valve repair: the lateral dislocation of the P2 technique.
    J Cardiovasc Med (Hagerstown) 2017 Sep;18(9):687-690
    Department of Cardiovascular Disease, IRCCS Centro Cardiologico Monzino, Milan, Italy.
    Background: Leaflet resection represents the reference standard for surgical treatment of mitral valve (MV) regurgitation. New approaches recently proposed place emphasis on respecting, rather than resecting, the leaflet tissue to avoid the drawbacks of the 'resection' approach.

    Objectives: The lateral dislocation of mid portion of mitral posterior leaflet (P2) technique for MV repair is a nonresectional technique in which the prolapsed P2 segment is sutured to normal P1 segment. Read More

    Cervical artery dissection expands the cardiovascular phenotype in FBN1-related Weill-Marchesani syndrome.
    Am J Med Genet A 2017 Sep 11;173(9):2551-2556. Epub 2017 Jul 11.
    Cardiovascular Genetics Program, Massachusetts General Hospital, Boston, Massachusetts.
    Weill-Marchesani syndrome (WMS) is a rare form of acromelic dysplasia that is characterized by distinctive skeletal, ocular, and cardiovascular abnormalities. Previously described cardiac manifestations of WMS include aortic and pulmonary valve stenosis, mitral valve prolapse, mitral stenosis, and QTc prolongation. Autosomal dominant forms of WMS result from heterozygous pathogenic variants in FBN1, a gene with a well characterized role in the pathogenesis of thoracic aortic aneurysm (TAA) in the context of Marfan syndrome. Read More

    Assessment of Mitral Valve Repair With Exercise Echocardiography: Artificial Chordae vs Leaflet Resection.
    Semin Thorac Cardiovasc Surg 2017 Spring;29(1):25-32. Epub 2017 Jan 10.
    Department of Cardiothoracic Surgery, Skane University Hospital, Lund University, Lund, Sweden.
    Mitral valve (MV) repair with artificial chordae (AC) or leaflet resection (LR) is associated with good hemodynamics at rest. The aim of this study was to compare these techniques in terms of exercise capacity and echocardiographic parameters of hemodynamics at rest and peak exercise. We conducted a study in 2015 of 56 patients, who had undergone surgery for degenerative posterior mitral leaflet prolapse between 2005 and 2014 using either AC (n = 24) or LR (n = 32). Read More

    Functional validation reveals the novel missense V419L variant in TGFBR2 associated with Loeys-Dietz syndrome (LDS) impairs canonical TGF-β signaling.
    Cold Spring Harb Mol Case Stud 2017 Jul 5;3(4). Epub 2017 Jul 5.
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
    TGF-β-related heritable connective tissue disorders are characterized by a similar pattern of cardiovascular defects, including aortic root dilatation, mitral valve prolapse, vascular aneurysms, and vascular dissections and exhibit incomplete penetrance and variable expressivity. Because of the phenotypic overlap of these disorders, panel-based genetic testing is frequently used to confirm the clinical findings. Unfortunately in many cases, variants of uncertain significance (VUSs) obscure the genetic diagnosis until more information becomes available. Read More

    When your patient clicks: a loud clicking sound as a key sign to the diagnosis.
    BMJ Case Rep 2017 Jun 28;2017. Epub 2017 Jun 28.
    Department of Internal Medicine, Kantonsspital Baden, Baden, Switzerland.
    A 19-year-old male patient was referred by his general practitioner with a new 'cardiac murmur'. For 1 week, he had been able to provoke a clicking sound, which was in time with his heart beat and originated from his chest. The physical examination and laboratory tests were normal. Read More

    Efficacy of losartan as add-on therapy to prevent aortic growth and ventricular dysfunction in patients with Marfan syndrome: a randomized, double-blind clinical trial.
    Acta Cardiol 2017 Jun 28:1-9. Epub 2017 Jun 28.
    a Department of Medical Genetics , University Hospital Ghent , Ghent , Belgium.
    Background: Marfan syndrome (MFS) is a multisystemic hereditary connective tissue disease. Aortic root aneurysms and dissections are the most common and life-threatening cardiovascular disorders affecting these patients. Other cardiac manifestations include mitral valve prolapse, ventricular dysfunction and arrhythmias. Read More

    Transforming Growth Factor Beta-2 Mutations in Barlow's Disease and Aortic Dilatation.
    Ann Thorac Surg 2017 Jul;104(1):e19-e21
    Department of Cardiac Surgery, Central Hospital Bad Berka, Bad Berka, Germany; Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany.
    We report on a patient operated on for degenerative myxomatous mitral and tricuspid valve disease (Barlow's disease) and aortic root dilatation. A valve repair operation and the postoperative course were uneventful. Multigenerational genetic analyses revealed two different mutations in the transforming growth factor beta-2 gene in the same patient. Read More

    Routine echocardiography in patients with myotonic dystrophy type 1.
    J Chin Med Assoc 2017 Jul 7;80(7):408-412. Epub 2017 Jun 7.
    Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia. Electronic address:
    Background: Myotonic dystrophy type 1 (DM1) is an autosomal-dominant disease. One third of DM1 patients die suddenly, most of them due to the heart conduction abnormalities and arrhythmias. The aim of this study was to analyze echocardiographic findings in a large cohort of DM1 patients. Read More

    [Mitral Valve Repair in a Patient with Two Aneurysms of the Mitral Valve Due to Infective Endocarditis;Report of a Case].
    Kyobu Geka 2017 Jun;70(6):445-448
    Department of Cardiovascular Surgery, Yamato Seiwa Hospital, Yamato, Japan.
    Echocardiography revealed 2 aneurysms in the mitral valve with mitral regurgitation and aortic regurgitation,in a 42-years-old man. He had had infective endocarditis due to Streptococcus 9 months before. A prolapse in the right coronary cusp without vegetation and 2 aneurysms in the anterior mitral leaflet were found intraoperatively. Read More

    Postoperative Echocardiographic Reduction of Right Ventricular Function: Is Pericardial Opening Modality the Main Culprit?
    Biomed Res Int 2017 14;2017:4808757. Epub 2017 May 14.
    Department of Cardiology and Cardiac Surgery, Centro Cardiologico Monzino, IRCCS, University of Milan, Milan, Italy.
    Echocardiographic reduction of RV function, measured using TAPSE, is a well described phenomenon after cardiac surgery. The aim of the present study was to investigate the relation between the modality of pericardial opening (lateral versus anterior) and the postoperative right ventricular systolic function by comparing echocardiographic parameters in patients undergoing minimally invasive or traditional mitral valve repair. 34 patients with severe mitral regurgitation due to mitral valve prolapse underwent traditional (sternotomy) operation (Group A) or minimally invasive surgery with right anterolateral thoracotomy (Group B). Read More

    Minimally invasive mitral valve repair in osteogenesis imperfecta.
    Interact Cardiovasc Thorac Surg 2017 Oct;25(4):665-666
    Istituto Clinico Ligure di Alta Specialità (ICLAS), Rapallo, Italy.
    Osteogenesis imperfecta is a disorder of the connective tissue that affects several structures including heart valves. However, cardiac surgery is associated with high mortality and morbidity rates. In a 48-year-old man with osteogenesis imperfecta and mitral valve prolapse, we performed the first successful mitral valve repair by right anterior mini-thoracotomy. Read More

    Mitral valve prolapse and Marfan syndrome.
    Congenit Heart Dis 2017 Jul 5;12(4):430-434. Epub 2017 Jun 5.
    Department of Cardiac Surgery, Leeds General Infirmary, Great George Street, Leeds, United KIngdom.
    Marfan syndrome is a multisystemic genetic condition affecting connective tissue. It carries a reduced life expectancy, largely dependent on cardiovascular complications. More common cardiac manifestations such as aortic dissection and aortic valve incompetence have been widely documented in the literature. Read More

    Prolapse Volume to Prolapse Height Ratio for Differentiating Barlow's Disease From Fibroelastic Deficiency.
    Circ J 2017 May 31. Epub 2017 May 31.
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University.
    Background: As mitral valve (MV) repair for Barlow's disease remains surgically challenging, it is important to distinguish Barlow's disease from fibroelastic deficiency (FED) preoperatively. We hypothesized that the prolapse volume to prolapse height ratio (PV-PH ratio) may be useful to differentiate Barlow's disease and FED.Methods and Results:In 76 patients with MV prolapse who underwent presurgical transesophageal echocardiography, the 3D MV morphology was quantified: 19 patients were diagnosed with Barlow's disease and 57 with FED. Read More

    Randomised trial of mitral valve repair with leaflet resection versus leaflet preservation on functional mitral stenosis (The CAMRA CardioLink-2 Trial).
    BMJ Open 2017 May 30;7(5):e015032. Epub 2017 May 30.
    Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, Ontario, Canada.
    Background: The gold-standard treatment of severe mitral regurgitation (MR) due to degenerative disease is valve repair, which is surgically performed with either a leaflet resection or leaflet preservation approach. Recent data suggest that functional mitral stenosis (MS) may occur following valve repair using a leaflet resection strategy, which adversely affects patient prognosis. A randomised comparison of these two approaches to mitral repair on functional MS has not been conducted. Read More

    Aortic Root Surgery in Marfan Syndrome: Medium-Term Outcome in a Single-Center Experience.
    J Heart Valve Dis 2017 Jan;26(1):45-53
    Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota, USA.
    Background: The study aim was to analyze the authors' experience with aortic root surgery in Marfan syndrome (MFS), and to expand the surgical outcome data of patients meeting the Ghent criteria (Marfan registry).

    Methods: Analyses were performed of data acquired from MFS patients (who met the Ghent criteria), including an aortic root surgery and Kaplan-Meier survival.

    Results: Between April 2004 and February 2012, a total of 59 MFS patients (mean age at surgery 36 ± 13 years) underwent 67 operations for aortic root aneurysm (n = 52), aortic valve (AV) regurgitation (n = 15), acute aortic dissection (n = 2), and/or mitral valve (MV) regurgitation resulting from MV prolapse (n = 7). Read More

    Dynamic and quantitative evaluation of degenerative mitral valve disease: a dedicated framework based on cardiac magnetic resonance imaging.
    J Thorac Dis 2017 Apr;9(Suppl 4):S225-S238
    Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.
    Background: Accurate quantification of mitral valve (MV) morphology and dynamic behavior over the cardiac cycle is crucial to understand the mechanisms of degenerative MV dysfunction and to guide the surgical intervention. Cardiac magnetic resonance (CMR) imaging has progressively been adopted to evaluate MV pathophysiology, although a dedicated framework is required to perform a quantitative assessment of the functional MV anatomy.

    Methods: We investigated MV dynamic behavior in subjects with normal MV anatomy (n=10) and patients referred to surgery due to degenerative MV prolapse, classified as fibro-elastic deficiency (FED, n=9) and Barlow's disease (BD, n=10). Read More

    1 OF 133