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J Vet Sci 2018 Dec 4. Epub 2018 Dec 4.

Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, 05030, Korea.

Genome-wide association study (GWAS) is a powerful tool for identifying the genetic causes of various diseases. This study conducted to identify genomic variation in Maltese dog genomes associated with degenerative mitral valve disease (DMVD) development and evaluate the association of each biological condition with DMVD in Maltese dogs. DNA was extracted from blood samples obtained from 48 Maltese dogs (32 with DMVD and 16 controls). Read More

Am J Cardiol 2019 Jan 26;123(1):75-83. Epub 2018 Sep 26.

Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

Functional mitral regurgitation (FMR) is common in heart failure (HF), and negatively impacts prognosis. Cardiac resynchronization therapy (CRT) can improve FMR, but the long-term changes in and impact of FMR after CRT are still unclear. The present study investigated the prevalence, evolution and impact on mortality of FMR before and after CRT in patients with HF. Read More

Int J Cardiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Research, Innovation and Brand Reputation, ASST Papa Giovanni XXIII, Bergamo, Italy. Electronic address:

Aims: Direct oral anticoagulant (DOAC) has been recently introduced in the clinical practice. Rather than interfering with vitamin K-dependent posttranscriptional modification of various proteins, DOACs selectively inhibit factors involved in the coagulation cascade. In particular, in contrast with Warfarin, Rivaroxabn does not interfere with activation of matrix Gla Protein (MGP), a potent vascular calcification Inhibitor. Read More

J Cardiol Cases 2014 Jun 18;9(6):233-235. Epub 2014 Apr 18.

Cardiovascular Division, Department of Medicine II, Kansai Medical University, Osaka, Japan.

A patient without any known congenital cardiac abnormalities who suffered from ventricular tachycardia was taken to the emergency room following successful resuscitation. Transthoracic echocardiography showed diffuse left ventricle dysfunction and mild aortic regurgitation. Coronary angiography demonstrated intact coronary and suspected morphological abnormalities of the aortic valve. Read More

J Cardiol Cases 2014 May 24;9(5):208-210. Epub 2014 Feb 24.

Division of Cardiology, SUNY Downstate Medical Center, Brooklyn, New York, NY, USA.

We report a case of "rectangular (quadrangular) heart" seen on the chest X-ray. Full evaluation showed massive enlargement of right-sided chambers shadowing the left-sided chambers. Primary etiology of the right-sided failure was attributed to severe mitral and tricuspid regurgitation for which the patient underwent surgery. Read More

J Cardiol Cases 2014 Mar 3;9(3):124-126. Epub 2014 Jan 3.

Atherosclerosis Prevention Research Center, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Acquired fistulous communication with the left atrial (LA) chamber has been described in the presence of LA mural thrombus in patients with rheumatic mitral stenosis (MS). Hereby, we present the case of a 74-year-old man with rheumatic MS and a huge LA thrombus found in echocardiography. Coronary angiography revealed an extensive fistula formation feeding mainly from the atrial branches of left circumflex and right coronary arteries and draining into the LA chamber. Read More

J Cardiol Cases 2014 Mar 13;9(3):104-105. Epub 2013 Dec 13.

Cardiovascular and Thoracic Department, Rabta Hospital, Medical University of Tunis, Tunis, Tunisia.

Ischemic iatrogenic lesions can complicate surgical procedures on the mitral valve. One of the causative mechanisms is direct injury to or distortion of the circumflex coronary artery. The risk of damaging the circumflex coronary artery depends mainly upon the proximity of that vessel to the posterior segment of the mitral annulus, and this varies from patient to patient. Read More

J Cardiol Cases 2014 Feb 13;9(2):75-79. Epub 2013 Dec 13.

Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan.

A 64-year-old woman with recurrent mitral valve stenosis was hospitalized 30 years after open commissurotomy. Severe right cerebral embolism occurred at age 58, with left hemiparesis. She was debilitated with cardiac cachexia. Read More

J Cardiol Cases 2014 Feb 12;9(2):61-62. Epub 2013 Dec 12.

Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, Turkey.

A 64-year-old woman was admitted to our emergency department with shortness of breath and palpitation which started 2 h before her admission. She had a history of rheumatic mitral valve disease and was on drug treatment with warfarin and metoprolol. The patient was orthopneic, blood pressure was 108/68 mmHg with an irregular pulse with a heart rate of 158 beats per minute, and respiratory rate was 23 times per minute. Read More

J Cardiol Cases 2014 Feb 13;9(2):50-53. Epub 2013 Dec 13.

Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

Functional mitral regurgitation (MR) is a common complication accompanying left ventricular dysfunction. Increasing resting heart rate (HR) is demonstrated to be associated with increased mortality in heart failure (HF) patients. Thus, lowering HR is recommended by recent HF management guidelines. Read More

J Cardiol Cases 2014 Feb 16;9(2):48-49. Epub 2013 Dec 16.

Baylor College of Medicine, Section of Cardiology, Houston, TX, USA.

A 57-year-old male underwent mechanical mitral valve replacement for severe mitral regurgitation of a prolapsed myxomatous mitral valve. The patient's post-operative recovery period was uneventful until the eighth day when he decompensated into pulseless electrical activity arrest. A bedside transthoracic echocardiogram revealed a large, smooth-edged mass nearly obliterating the right atrial cavity. Read More

J Cardiol Cases 2015 Feb 25;11(2):69-72. Epub 2014 Nov 25.

Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.

A 65-year-old man with a history of hypertension was admitted to our hospital with fainting and syncope. He had experienced recurrent syncope since 20 years of age. On admission, systolic heart murmur was audible at the apex of the heart. Read More

J Cardiol Cases 2015 Feb 31;11(2):44-47. Epub 2014 Oct 31.

Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Massive calcification of the left atrium is an uncommon complication of long-standing rheumatic valve disease, and is frequently revealed in patients with a previous operation on the mitral valve. An 84-year-old woman, who had a history of rheumatic valvulopathy and mitral-aortic valve replacement surgery 35 years previously, was admitted to our hospital due to congestive heart failure. Chest X-ray showed severe cardiomegaly with rim of calcification outlining the enlarged left atrium. Read More

J Cardiol Cases 2014 Oct 23;10(4):147-149. Epub 2014 Jul 23.

Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.

We describe a case of a 54-year-old patient with rheumatic heart valve disease who was treated with double valve replacement (both aortic and mitral) twice. Two months after the second operation she developed a severe mitral paravalvular leakage (PVL) leading to cardiogenic shock for which she was hospitalized in the intensive care unit. Multiple weaning efforts proved to be unsuccessful because of persistent hemodynamic instability caused by the severe PVL. Read More

J Cardiol Cases 2014 Oct 15;10(4):125-128. Epub 2014 Jul 15.

Wake Forest Baptist Medical Center, Winston Salem, NC, USA.

Papillary fibroelastoma (PFE) is a rare benign tumor that most commonly involves heart valves. Cardiac PFE involving the mitral chorda is rarer. Most papillary PFE are asymptomatic; rarely, they are diagnosed because of cardiac symptoms or after an embolic event. Read More

J Cardiol Cases 2014 Jul 1;10(1):22-24. Epub 2014 May 1.

Teaching Hospital Kandy, Kandy, Sri Lanka.

Bacterial endocarditis gives rise to a variety of complications due to local tissue damage, immunological phenomena, and embolic phenomena. Only a small number of cases of coronary embolization have been reported in infective endocarditis patients. This is a case of subacute bacterial endocarditis in a postpartum mother complicated by fatal left and right coronary artery embolization. Read More

J Cardiol Cases 2013 Jun 18;7(6):e164-e167. Epub 2013 Mar 18.

La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain.

Primary cardiac sarcomas are rare. A 63-year-old woman presented with progressive symptoms of fatigue, palpitations, and dyspnea. Transthoracic echocardiography detected a mass in the left atrium, fixed and probably attached to the interatrial septum suggestive of myxoma. Read More

J Cardiol Cases 2013 Feb 8;7(2):e48-e50. Epub 2012 Dec 8.

Department of Second Section of Cardiology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5 Fuxing Street, Guishan Township, Taoyuan County 33305, Taiwan.

Loss of voice due to vocal cord paralysis, as in Ortner syndrome, is secondary to left recurrent laryngeal nerve palsy. Cardiovascular cause should be listed as a differential diagnosis of hoarseness and is incumbent upon the diagnostic physician to be familiar with the condition. A 56-year-old male presented to our emergency department with shortness of breath due to severe mitral regurgitation. Read More

J Cardiol Cases 2013 Feb 4;7(2):e37-e41. Epub 2012 Dec 4.

Department of Myocardial Dysfunction and Heart Failure, B.V. Petrovsky Russian Research Centre of Surgery RAMS, 119991, Abrikosovky per, 6, Moscow, Russia.

LEOPARD syndrome is a phenotypic expression of mutations in several genes: PTPN11, RAF1, and BRAF. All these genes are responsible for Ras/MARK signaling pathway, which are important for cell cycle regulation, differentiation, growth, and aging. Mutations result in anomalies of skin, skeletal, and cardiovascular systems. Read More

J Cardiol Cases 2013 Jan 5;7(1):e15-e17. Epub 2012 Oct 5.

Department of Cardiovascular Surgery, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Istanbul, Turkey.

Infective endocarditis (IE) remains a serious and deadly disease despite recent advances in diagnosis and treatment. In all IE cases, the rate of healthcare-associated IE has been reported as 23%. Aortic valve endocarditis may extend to mitral-aortic intervalvular fibrosa (MAIVF), which may cause pseudoaneurysm formation and subsequent perforation. Read More

J Cardiol Cases 2012 Nov 14;6(5):e150-e153. Epub 2012 Aug 14.

Department of Cardiology, Chonnam National University Hospital, 42 Jebong-ro, Dong-gu, Gwangju 501-757, South Korea.

Cardiac tumor can produce a variety of symptoms and clinical findings depending on the location, size, and histologic type. It may cause heart failure usually by interfering with intracardiac blood flows associated with the mass effects. Here, we report an extremely rare case of heart failure caused by primary cardiac sarcoma with a review of the literature. Read More

J Cardiol Cases 2012 Nov 9;6(5):e137-e140. Epub 2012 Aug 9.

Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan.

An 81-year-old woman had undergone percutaneus coronary intervention to mid left anterior descending coronary artery with a drug-eluting stent for effort angina pectoris. Although she had remained asymptomatic for 3 years, she developed cardiogenic shock following acute myocardial infarction due to stent thrombosis. Her condition deteriorated despite successful revascularization and an initiation of intra-aortic balloon pump (IABP). Read More

J Cardiol Cases 2012 Jul 16;6(1):e13-e16. Epub 2012 May 16.

Department of Cardiology, Japan Self Defense Forces Central Hospital, Tokyo, Japan.

Mitral annulus calcification (MAC) has been recognized as a potent risk factor to cause cerebral infarction. There has been suggested possible linkage between mass on MAC and systemic embolic events. We report a case of cerebral infarction with newly developed mobile mass superimposed on MAC. Read More

J Cardiol Cases 2012 Jul 31;6(1):e4-e7. Epub 2012 Mar 31.

Cardiology Department, Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, UK.

We report a case of severe rheumatic mixed mitral valve disease in a young adult male where a combination of imaging techniques was utilized. We demonstrate that cardiac magnetic resonance imaging may be used as an alternative imaging modality in patients not suitable for the more established techniques of transthoracic and transesophageal echocardiography. Additionally, the use of 3D-transesophageal imaging offered the cardiothoracic surgeon additional anatomical information at the time of mitral valve replacement. Read More

J Cardiol Cases 2012 Apr 12;5(2):e76-e79. Epub 2012 Jan 12.

Division of Cardiovascular Surgery, Tominaga Hospital, Osaka, Japan.

It is well known that post-infarction papillary muscle rupture of the anterolateral papillary muscle is less frequent than that of the posteromedial papillary muscle. This is thought to be due to a difference in blood supply (single vs dual) of the papillary muscles. Recently, we had two cases in which occlusion of the diagonal branch of the left anterior descending artery was found to be the culprit lesion of acute myocardial infarction leading to complete rupture of the anterolateral papillary muscle. Read More

J Cardiol Cases 2011 Dec 18;4(3):e156-e159. Epub 2011 Sep 18.

Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan.

An 86-year-old woman was referred to our hospital for the management of rapid onset of chest pain. Blood analysis showed increased levels of cardiac enzymes and B-type natriuretic peptide. An electrocardiogram showed poor R wave in precordial leads and a QS wave in lead V4. Read More

J Cardiol Cases 2011 Oct 19;4(2):e115-e120. Epub 2011 Aug 19.

Second Department of Internal Medicine, Kansai Medical University, Moriguchi City, Japan.

A 79-year-old female had paroxysmal supraventricular tachycardia. However, she was implanted with an inferior vena cava filter and her descending aorta had significant meandering. It was thought that the insertion of the catheters would be difficult from the femoral vessels. Read More

J Cardiol Cases 2011 Oct 22;4(2):e63-e66. Epub 2011 Jul 22.

Service de Chirurgie Cardiovasculaire, CHU de Clermont-Ferrand, BP 69-63003 Clermont-Ferrand, France.

We describe two cases of thrombosis after mitral valvuloplasty (MV). Antithrombotic therapy after MV in patients with no thromboembolic risk factors is essentially based on treatment with a platelet aggregation inhibitor. This strategy may not be sufficient in some cases and the introduction of oral anticoagulant therapy may be necessary. Read More

J Cardiol Cases 2011 Aug 25;4(1):e55-e57. Epub 2011 Jun 25.

Gazi University Medical Faculty, Department of Cardiology, Ankara, Turkey.

Fungal endocarditis is a relatively rare condition with particular difficulties in diagnosis and treatment. These difficulties lead to higher rates of mortality and morbidity. We report the successful treatment of a patient with rheumatic mitral valve who had fungal endocarditis due to Cushing syndrome caused by iatrogenic corticosteroid supplement. Read More

J Cardiol Cases 2011 Apr 20;3(2):e82-e85. Epub 2011 Feb 20.

Department of Cardiology, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia.

Infective endocarditis is a dynamic disease with changing epidemiology and diagnostic strategies. Culture negative endocarditis poses a particular problem for clinicians regarding appropriate antimicrobial therapy and adequate duration of therapy. Utilization of nucleic acid amplification techniques and subsequent sequencing has provided clinicians an alternative to traditional phenotypic microbial identification which has been extremely useful in identification of fastidious organisms. Read More

J Cardiol Cases 2011 Feb 8;3(1):e43-e45. Epub 2010 Oct 8.

Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences & Research, Bangalore, India.

We report the case of a 23-year-old female who underwent balloon mitral valvotomy for severe symptomatic mitral stenosis. Following septal puncture, the patient developed cardiac tamponade, which warranted sternotomy to suture the rent in the inferior vena cava-right atrial junction. The postoperative echocardiogram revealed nonhomogenous irregular opacities within the left atrium suggesting the possibility of thrombus formation. Read More

J Cardiol Cases 2010 Dec 8;2(3):e163-e165. Epub 2010 Aug 8.

Department of Cardiology, Tianjin Medical University General Hospital, 154, Anshan Road, Heping District, Tianjin 300052, China.

Pulmonary valve endocarditis is an extremely rare complication of aneurysm of the sinus of Valsalva. We report the case of a 26-year-old male patient who presented with pulmonary valve endocarditis which was associated with a ruptured aneurysm of the right sinus of Valsalva with aorto-right ventricular outflow tract fistula and aortic valve endocarditis. He underwent aortic valve replacement with a 23 mm pericardial bioprosthesis, reconstruction of the right sinus of Valsalva using a pericardial patch, and debridement of pulmonary valve leaflet vegetations. Read More

J Cardiol Cases 2010 Dec 7;2(3):e141-e143. Epub 2010 Jul 7.

Division of Cardiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.

Mitral annular calcification (MAC) is a common finding especially among the elderly. Caseous calcification of the mitral annulus (CCMA) is a rare variant of MAC, which may be mistaken for an intracardiac tumor or abscess. The clinical significance of CCMA and its potential as a source for cerebral embolism is not known. Read More

J Cardiol Cases 2010 Dec 11;2(3):e123-e127. Epub 2010 Jun 11.

Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

A 54-year old man was diagnosed with right lung carcinoma (squamous cell carcinoma, SCC), stage IIIB (c-T2N3M0). Transthoracic echocardiography (TTE) showed a huge 8.9 cm × 1. Read More

Wien Klin Wochenschr 2018 Dec;130(23-24):692-693

Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Cardiovasc J Afr 2018 Nov 30;29:1-4. Epub 2018 Nov 30.

Department of Paediatric Cardiology, Near East University Hospital, Nicosia, Cyprus.

Introduction: Coronary tortuosity (CorT) is a common coronary angiographic finding. The aetiology, clinical implication and long-term prognosis are not well clarified. Mitral annular calcification (MAC) is one of the most common cardiac structural abnormalities on echocardiographic examination. Read More

Rom J Morphol Embryol 2018 ;59(3):903-909

Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, Romania;

A 46-year-old female diagnosed several years ago with arterial hypertension and an ischemic stroke with significant recovery was admitted for dyspnea on usual physical activity and fatigue. Physical examination revealed signs of heart failure with crackles on both lung bases, distented jugular veins, accentuated pulmonic valve closure (P2) and tricuspid regurgitation murmur. Echocardiography identified a large tumor in the left atrium, suggestive of atrial myxoma, which caused a severe functional mitral stenosis and produced severe pulmonary hypertension. Read More

Echo Res Pract 2018 Dec;5(4):155-166

Division of Cardiovascular Medicine, University of Toledo Medical Center, Toledo, Ohio, USA.

Background This analysis aims to assess the prognostic value of pre-operative right ventricular echocardiographic parameters in predicting short-term adverse outcomes and long-term mortality after coronary artery bypass graft (CABG). Methods Study design: Observational retrospective cohort. Pre-operative echocardiographic data, perioperative adverse outcomes (POAO) and long-term mortality were retrospectively analyzed in 491 patients who underwent isolated CABG at a single academic center between 2006 and 2014. Read More

Gac Med Mex 2018 ;154(6):727-728

Universidad de Castilla-La Mancha, Hospital General Universitario de Albacete; Centro de Salud de Villanueva de la Jara. Castilla-La Mancha, España.

Eighty-year old woman with a medical history of arterial hypertension, rheumatic valvular heart disease with mitral and aortic valve replacement, chronic atrial fibrillation and congestive heart failure dependent on domiciliary chronic oxygen for 17 daily hours. The reason for arrival to the hospital was a stroke of cardioembolic etiology. Read More

Am J Case Rep 2018 Dec 11;19:1467-1473. Epub 2018 Dec 11.

Department of General Medicine, Saga University Hospital, Saga City, Saga, Japan.

BACKGROUND Infective endocarditis is prevalent worldwide and the modified Duke criteria have been used universally to diagnose this condition. However, making the correct diagnosis is rather difficult because the clinical presentation and findings of blood tests are non-specific. CASE REPORT A 70-year-old female complaining of dyspnea for 5 days with acute mitral regurgitation was transferred to our hospital. Read More

Ann Thorac Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Anesthesia, Shahid Gangalal National Heart Center, Kathmandu, Nepal; Department of Anesthesia, Nepal Mediciti, Lalitpur, Nepal.

We report a case of 42-year-old male with submitral aneurysm presenting to the emergency room in circulatory collapse with left ventricular obstruction and severe mitral valve stenosis and regurgitation due to the aneurysm. Resection of the aneurysm along with mitral valve replacement was done through a median sternotomy without any complication and good results. Read More

J Neurosci Methods 2018 Dec 6. Epub 2018 Dec 6.

Bates College, Program in Neuroscience, Lewiston, ME 04240, United States. Electronic address:

Background: The Allen Mouse Brain Atlas allows study of the brain's molecular anatomy at cellular scale, for thousands of. To fully leverage this resource, one must register histological images of brain tissue -- a task made challenging by the brain's structural complexity and heterogeneity, as well as inter-experiment variability.

New Method: We have developed a deep-learning based methodology for classification and registration of thousands of sections of brain tissue, using the mouse olfactory bulb (OB) as a case study. Read More

J Cardiothorac Vasc Anesth 2018 Sep 25. Epub 2018 Sep 25.

Department of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, OH.

Heart Lung Circ 2018 Nov 30. Epub 2018 Nov 30.

St Vincent's Hospital, Melbourne, Victoria, Australia.

Background: The Cox-Maze IV procedure is a proven surgical treatment for atrial fibrillation (AF). Previous studies on the procedure and its effect on left atrial mechanical function have yielded mixed results.

Methods: Sixty-four patients underwent Cox-Maze IV at St Vincent's Hospital, Melbourne between March 2010 and May 2016. Read More

Rev Port Cardiol 2018 Dec 7. Epub 2018 Dec 7.

Cardiothoracic Surgery Department, Centro Hospitalar de São João, Porto, Portugal.

Introduction: Papillary fibroelastoma (PFE) is a rare primary benign tumor of cardiac origin that predominantly affects the cardiac valves. Although most patients are asymptomatic, serious complications may result given their propensity for embolization. Advances in imaging technology have enabled earlier detection and more accurate characterization of these tumors. Read More

Int J Infect Dis 2018 Dec 5. Epub 2018 Dec 5.

Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Brazil; Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil; Instituto Nacional de Ciência e Tecnologia em Investigação em Imunologia (iii-INCT), São Paulo, Brazil.

Background: The immunological and clinical impact of trypanocidal treatment in chronic Chagas' disease (CCD) is unclear.

Methodology And Findings: Several cytokines were measured in plasma of 66 patients with CCD. Thirty-three patients had been previously treated with benznidazole and 33 had never been treated. Read More

J Thorac Cardiovasc Surg 2018 Oct 23. Epub 2018 Oct 23.

Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia; Vascular Surgical Unit, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

Am J Cardiol 2018 Oct 19. Epub 2018 Oct 19.

Albert Einstein Medical Center, Division of Cardiology, Philadelphia, Pennsylvania.

Echocardiographic calcifications are associated with major adverse cardiovascular events (MACE). A recently described semiquantitative Global Cardiac Calcium Score (GCCS) has been associated with mortality and stroke, with increasing scores associated with increasing risk. This score assigns points for calcium in the aortic root and valve, mitral valve and annulus, and submitral apparatus, with additional points for restricted leaflet mobility. Read More

J Thorac Cardiovasc Surg 2018 Sep 29. Epub 2018 Sep 29.

Department of Cardiothoracic Surgery, Huashan Hospital of Fudan University, Shanghai, China. Electronic address:

Objective: Focusing on 3-dimensional mitral valve structure, this study investigated predictors for moderate ischemic mitral regurgitation (IMR) improvement after off-pump coronary artery bypass grafting (OPCAB).

Methods: This study included 143 patients (age 67.6 ± 7. Read More

J Surg Res 2019 Feb 12;234:249-261. Epub 2018 Oct 12.

Department of Cardiac, Thoracic and Vascular Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; National University Hospital, National University Health System, Singapore.

Background: Experimental surgical procedures for atrioventricular valves present promising translational capabilities, and preclinical studies are necessary to assess their applicability and to train young enthusiastic heart teams. Here, we present a synopsis of experimental surgical procedures on porcine models for mitral valvular (MV) and tricuspid valvular (TV) interventions; mitral valve-in-valve implantation (MViV), transapical cardioscopic (TAC) MV replacement (MVR), TAC-MV annuloplasty, and tricuspid valve-in-a-ring (TViR) procedures.

Methods: Twenty-five (n = 25) female Yorkshire pigs of 55-65 kg is the total number used in the four approaches; seven animals underwent MViV, six TAC-MVR, six TAC-MV annuloplasty, and six TViR, respectively. Read More