78,778 results match your criteria Mitral Stenosis


Left Ventricular End-Systolic Volume Can Predict 1-Year Hierarchical Clinical Composite End Point in Patients with Cardiac Resynchronization Therapy.

Yonsei Med J 2019 Jan;60(1):48-55

Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: This study aimed to elucidate which echocardiographic criteria at three time points, for cardiac resynchronization therapy (CRT) response, are accurate in discriminating the hierarchical clinical composite end point (HCCEP).

Materials And Methods: We included 120 patients (age, 66.1±12. Read More

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January 2019

A novel approach of clipping the mitral valve.

Cardiovasc Revasc Med 2018 Nov 30. Epub 2018 Nov 30.

Saint Joseph's Hospital and Medical Center, Phoenix, AZ, USA. Electronic address:

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November 2018

Percutaneous Aortic-to-Right Atrial Fistula Closure as a Complication of Surgical Aortic Valve Replacement.

JACC Cardiovasc Interv 2018 Dec 7. Epub 2018 Dec 7.

Division of Cardiology, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

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December 2018

Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Division of Cardiology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas.

Traditional approaches to the characterization of secondary or functional mitral regurgitation (MR) have largely ignored the critical importance of the left ventricle (LV). We propose that patients with secondary MR represent a heterogenous group, which can be usefully subdivided based on understanding that the effective regurgitant orifice area (EROA) is dependent on left ventricular end-diastolic volume (LVEDV). According to the Gorlin hydraulic orifice equation, patients with heart failure, an LV ejection fraction of 30%, an LVEDV of 220 to 250 ml, and a regurgitant fraction of 50% would be expected to have an EROA of ≈0. Read More

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December 2018

Feasibility of transcatheter prosthetic paravalvular leakage closure: a single-center, exploratory safety evaluation study of transcatheter closure of prosthetic paravalvular regurgitation in Japan (STOP PARA study).

Gen Thorac Cardiovasc Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Japan.

Objective: The standard treatment of prosthetic paravalvular leakage (PVL) accompanied by heart failure or hemolytic anemia is repeat open surgery. Although favorable outcomes for transcatheter prosthetic PVL closure in patients with a high surgical risk for repeat open surgery have been reported, procedural feasibility has not been examined in Japan.

Methods: From March 2015 to November 2015, transcatheter PVL closure in mitral position was performed in four patients (age range 41-78, three females) with high surgical risk due to history of repeated surgeries, chest radiation and reconstruction of the mitral annulus after debridement of abscess owing to infective endocarditis. Read More

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December 2018
2 Reads

Left ventricular hypertrophy is a possible biomarker for early mortality after type B aortic dissection.

J Vasc Surg 2018 Dec 11. Epub 2018 Dec 11.

Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle, Wash. Electronic address:

Objective: Data regarding the cardiac abnormalities associated with Stanford type B aortic dissection (TBAD) and whether these abnormalities are related to outcomes are limited. We describe the prevalence of cardiac abnormalities in patients with TBAD as detected by echocardiography.

Methods: This retrospective review included patients with TBAD presenting between 1990 and 2016. Read More

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December 2018

Fracture of a Transcatheter Atrial Septal Defect Occluder Device Causing Mitral Valve Perforation.

Ann Thorac Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland; Department of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland.

Transcatheter atrial septal defect (ASD) device closure has gained increasing popularity over the past decades due to shorter hospital stay and the absence of skin scars. However, concern about the seriousness of device-related complications is accumulating. We report a case of device fracture in a young asymptomatic woman almost 4 years after percutaneous secundum ASD closure, resulting in mitral valve perforation. Read More

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December 2018
4 Reads

Repair of tricuspid papillary muscle rupture after percutaneous coronary intervention.

Authors:
Shinji Kanemitsu

Multimed Man Cardiothorac Surg 2018 Dec 6;2018. Epub 2018 Dec 6.

Department of Thoracic and Cardiovascular Surgery Mie University Graduate School of Medicine 2-174 Edobashi, Tsu, Mie 514-8507, Japan.

Papillary muscle rupture is a rare complication after myocardial infarction and almost all cases occur in the mitral valve papillary muscle. Tricuspid regurgitation development after right ventricular myocardial infarction caused by papillary muscle rupture is extremely rare.  In this video tutorial we present a 70-year-old man with massive tricuspid regurgitation caused by papillary muscle rupture after percutaneous stenting of the right coronary artery. Read More

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December 2018

Minimally invasive triple valve surgery: The Rome approach.

Multimed Man Cardiothorac Surg 2018 Dec 4;2018. Epub 2018 Dec 4.

Department of Cardiac Surgery and Transplantation, S. Camillo Hospital, Rome, Italy.

Although the benefits of minimally invasive cardiac surgery are well recognized, most surgeons have little experience in the treatment of triple valve disease through a minithoracotomy approach. In this video tutorial, we present a case of concomitant aortic valve replacement with mitral and tricuspid valve repair through a lateral minithoracotomy. Read More

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December 2018

Left ventricular reverse remodelling predicts long-term outcomes in patients with functional mitral regurgitation undergoing MitraClip therapy: results from a multicentre registry.

Eur J Heart Fail 2018 Dec 13. Epub 2018 Dec 13.

Civil Hospital and University of Brescia, Brescia, Italy.

Aims: To explore whether left ventricular reverse remodelling (LVRR) is a predictor of outcomes in patients with functional mitral regurgitation (FMR) undergoing MitraClip procedure.

Methods And Results: We analysed 184 consecutive patients with FMR who underwent successful MitraClip procedure. LVRR was defined as a reduction in left ventricular end-systolic volume ≥ 10% from baseline to 6 months. Read More

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December 2018

Human native endocarditis caused by Streptococcus canis-a case report.

APMIS 2019 Jan;127(1):41-44

Centre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic.

We report a very rare case of Streptococcus canis native infective endocarditis in a 73-year-old woman living in close contact with her dog. Her echocardiography showed large calcifications in the mitral annulus, massive regurgitation below the posterior leaflet, and adjacent vegetation. Blood culture was positive for Streptococcus Lancefield group G. Read More

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January 2019
2 Reads

Insights into the Pulmonary Vascular complications of heart failure with Preserved Ejection Fraction.

J Physiol 2018 Dec 13. Epub 2018 Dec 13.

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.

Pulmonary hypertension in the setting of heart failure with preserved ejection fraction (PH-HFpEF) is a growing public health problem that is increasing in prevalence. While PH-HFpEF is defined by a high mean pulmonary artery pressure, high left ventricular end-diastolic pressure and a normal ejection fraction, some HFpEF patients develop PH in the presence of pulmonary vascular remodeling with a high transpulmonary pressure gradient or pulmonary vascular resistance. Aging, increased left atrial pressure and stiffness, mitral regurgitation, as well as features of metabolic syndrome, which include obesity, diabetes, and hypertension, are recognized as risk factors for PH-HFpEF. Read More

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December 2018

Redo mitral valve surgery following prior mitral valve repair.

J Card Surg 2018 Dec 12. Epub 2018 Dec 12.

Division of Cardiovascular Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: The optimal treatment strategy following a failed mitral valve repair remains unclear. This study evaluated early and long-term outcomes of redo mitral valve repair (MVr) and replacement (MVR) after prior mitral valve repair.

Methods: Patients undergoing redo mitral valve surgery after prior mitral valve repair at a single institution between 2002 and 2014 were reviewed. Read More

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December 2018
1 Read

Hypertrophic cardiomyopathy with dynamic obstruction and high left ventricular outflow gradients associated with paradoxical apical ballooning.

Echocardiography 2018 Dec 12. Epub 2018 Dec 12.

Mount Sinai West, Icahn School of Medicine at Mount Sinai, New York City, New York.

Background: Acute left ventricular (LV) apical ballooning with normal coronary angiography occurs rarely in obstructive hypertrophic cardiomyopathy (OHCM); it may be associated with severe hemodynamic instability.

Methods, Results: We searched for acute LV ballooning with apical hypokinesia/akinesia in databases of two HCM treatment programs. Diagnosis of OHCM was made by conventional criteria of LV hypertrophy in the absence of a clinical cause for hypertrophy and mitral-septal contact. Read More

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December 2018

Quantification of rheumatic mitral stenosis severity with three-dimensional vena contracta area.

Echocardiography 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiology, Marmara University Medical Center, Istanbul, Turkey.

Introduction: Rheumatic mitral stenosis (MS) is an important health issue in developing countries. Assessment of the correct mitral valve area (MVA) is essential for the timing of intervention. Most of the parameters for the assessment of rheumatic MS are derived from Two-dimensional (2D) echocardiography. Read More

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December 2018

Relation of Left Atrial Appendage Closure Devices to Topographic Neighboring Structures using Standardized Imaging by Cardiac Computed Tomography Angiography.

Clin Cardiol 2018 Dec 11. Epub 2018 Dec 11.

First Department of Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, European Center for AngioScience (ECAS), and DZHK (German Center for Cardiovascular Research) partner site Heidelberg/Mannheim, Mannheim, Germany.

Background: Although left atrial appendage (LAA) anatomy and topographic relations are well understood, little is known about the impairment of neighboring structures (NBS) by an implanted left atrial appendage closure (LAAC) device. This prospective longitudinal observational study for the first time describes distances of implanted LAAC devices to NBS using a standardized imaging protocol of cardiac computed tomography angiography (cCTA).

Hypothesis: cCTA imaging is an eligible tool for post-implantation evaluation of LAAC devices and their relation to neighboring structures. Read More

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December 2018
1 Read

Long-term outcome of a dilated cardiomyopathy patient after mitral valve surgery combined with tissue-engineered myoblast sheets-report of a case.

Surg Case Rep 2018 Dec 13;4(1):142. Epub 2018 Dec 13.

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.

Background: Dilated cardiomyopathy (DCM) is a life-threatening heart muscle disease characterized by progressive heart failure, which often requires left ventricular assist device (LVAD) implantation or heart transplantation (HTx). A tissue engineering strategy using cell sheets for end-stage heart failure has emerged in recent years.

Case Presentation: Here, we describe a 50-year-old DCM patient with severe symptoms of heart failure with severe mitral regurgitation (MR) who was not a candidate for LVAD or HTx. Read More

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December 2018
2 Reads

Left Ventricular Structure and Function in Elite Swimmers and Runners.

Front Physiol 2018 28;9:1700. Epub 2018 Nov 28.

Human Performance and Health Research Laboratory, University of Guelph, Guelph, ON, Canada.

Sport-specific differences in the left ventricle (LV) of land-based athletes have been observed; however, comparisons to water-based athletes are sparse. The purpose of this study was to examine differences in LV structure and function in elite swimmers and runners. Sixteen elite swimmers [23 (2) years, 81% male, 69% white] and 16 age, sex, and race matched elite runners participated in the study. Read More

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November 2018

[Borderline left ventricular ejection fraction is associated with alterations in mitral annular size and function. Results from the three-dimensional speckle-tracking echocardiographic MAGYAR-Healthy Study].

Orv Hetil 2018 Dec;159(50):2129-2135

II. Belgyógyászati Klinika és Kardiológiai Központ, Szegedi Tudományegyetem, Általános Orvostudományi Kar, Szent-Györgyi Albert Klinikai Központ Szeged, Semmelweis u. 8., 6725.

Introduction: Morphology and function of the mitral annulus (MA) shows alterations in different valvular (for instance in mitral regurgitation) and non-valvular disorders (for instance in certain cardiomyopathies, cardiac amyloidosis).

Aim: The aim of the present study was to examine the relationship between MA morphologic and functional properties and three-dimensional speckle-tracking echocardiography- (3DSTE) derived left ventricular (LV) ejection fraction (EF) in subjects with normal versus borderline LV-EF.

Method: The present study comprised 146 volunteers (mean age: 32. Read More

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December 2018

CRT Pacing: Midterm Follow-Up in LV Only Pacing without RV Lead in Patients with Normal AV Conduction.

J Clin Med 2018 Dec 8;7(12). Epub 2018 Dec 8.

University of Medicine and Pharmacy "Carol Davila", 014451 Bucharest, Romania.

Background: The aim of our study was to assess the real life cardiac resynchronization therapy (CRT) fusion left ventricular (LV) only pacing in patients with normal AV conduction (NAVc) without right ventricular (RV) lead.

Methods: Consecutive NAVc patients with CRT indication were implanted with a right atrium RA/LV DDD pacing system. Complete follow-up at 1, 3 and every 6 months thereafter included echocardiography and stress testing. Read More

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December 2018

Outcomes After the MitraClip Procedure in Patients at Very High Risk for Conventional Mitral Valve Surgery.

Innovations (Phila) 2018 Nov/Dec;13(6):433-437

From the Divisions of Cardiothoracic Surgery and.

Objective: Approximately 50% of patients with severe symptomatic mitral regurgitation are deemed too high risk for surgery. The MitraClip procedure is a viable option for this population. Our goal was to assess outcomes and survival of patients who underwent the MitraClip procedure at an institution where mitral valve surgery is routinely performed. Read More

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December 2018

Characteristics of pulmonary infection after mitral valve repair in patients with metabolic syndrome and its relationship with blood pressure, blood glucose and blood lipid.

Exp Ther Med 2018 Dec 9;16(6):5003-5008. Epub 2018 Oct 9.

Department of Cardiac Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China.

Characteristics of pulmonary infection after mitral valve repair in patients with metabolic syndrome (MS) and its relationships with blood pressure, blood glucose and blood lipid were investigated. Clinical data of 126 patients were retrospectively analyzed, and patients were divided into infection group (n=19) and non-infection group (n=107). The differences of MS components in patients between the two groups were compared, and the distribution of pathogens and related factors of pulmonary infection were analyzed. Read More

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December 2018

Propensity-matched analysis of minimally invasive approach versus sternotomy for mitral valve surgery.

Heart 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiothoracic Surgery, Lancashire Cardiac Centre, Blackpool, UK.

Objective: The objective of this multicentre study was to compare short-term and midterm outcomes between sternotomy and minimally invasive approaches for mitral valve surgery.

Methods: Data for all mitral valve procedures with or without concomitant tricuspid atrial fibrillation surgery were analysed from three UK hospitals between January 2008 and December 2016. To account for selection bias between minimally invasive approach and sternotomy, one-to-one propensity score calliper matching without replacement was performed. Read More

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December 2018

Reduction of sleep-disordered breathing following effective percutaneous mitral valve repair with the MitraClip system.

Sleep Breath 2018 Dec 6. Epub 2018 Dec 6.

Division of Cardiology, Pulmonology and Vascular Medicine, Heinrich-Heine University Medical Center Duesseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany.

Purpose: This study tested the hypothesis that a reduction of pulmonary congestion achieved by a reduction of mitral regurgitation (MR) severity in heart failure (HF) patients is associated with reduced event lengths of sleep-disordered breathing (SDB).

Methods: We prospectively enrolled 20 consecutive HF patients who underwent MitraClip implantation. Patients underwent cardiorespiratory polygraphic recording prior to and after percutaneous mitral valve repair (PMVR). Read More

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December 2018

Intermediate-term outcomes of our original multiple-knot technique using ePTFE sutures for anterior mitral leaflet prolapse.

Surg Today 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiovascular Surgery, Osaka Rosai Hospital, 1179-3, Nagasone-cho, Kita-ku, Sakai, Osaka, Japan.

Purpose: To define the outcomes of our original simple chordal replacement technique using ePTFE sutures for mitral regurgitation.

Methods: Between January, 2004 and March, 2014, 38 patients underwent mitral valve repair using our chordal replacement technique for anterior leaflet prolapse. The mitral regurgitation was caused by degenerative disease in 34 patients and infective endocarditis in 4 patients. Read More

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December 2018

Arrhythmic Mitral Valve Prolapse: JACC Review Topic of the Week.

J Am Coll Cardiol 2018 Dec;72(23 Pt A):2904-2914

Helmsley Electrophysiology Center, Icahn School of Medicine at Mount Sinai, New York, New York.

There is an increasing awareness of the association between mitral valve prolapse and sudden cardiac death. There are several clinical risk factors associated with an increased risk of mitral valve prolapse-related sudden cardiac death, most of which can be evaluated with noninvasive diagnostic modalities. For example, characteristic changes on the electrocardiogram (T-wave inversions in the inferior leads), complex ventricular ectopy, a spiked configuration of the lateral annular velocities by echocardiography, and evidence of myocardial fibrosis by cardiac magnetic resonance imaging have all been implicated as markers of risk. Read More

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December 2018

Pulsed Doppler Echocardiography: An Historical Perspective.

Authors:
Julius M Gardin

J Am Soc Echocardiogr 2018 Dec;31(12):1330-1343

Division of Cardiology, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address:

Over the past six decades, echocardiography has evolved into an important technique for not only imaging cardiac structures, but also, by employing the Doppler equation, for assessing cardiac blood flow and tissue velocities. This review focuses on pulsed Doppler echocardiography: its principles, early development, and clinical applications. Important clinical applications include: (1) measurement of flow velocities, stroke volumes, and regurgitant and shunt volumes; (2) assessment of time intervals, e. Read More

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December 2018

Genome-wide association study of degenerative mitral valve disease in Maltese dogs.

J Vet Sci 2018 Dec 4. Epub 2018 Dec 4.

Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, 05030, Korea.

Genome-wide association study (GWAS) is a powerful tool for identifying the genetic causes of various diseases. This study conducted to identify genomic variation in Maltese dog genomes associated with degenerative mitral valve disease (DMVD) development and evaluate the association of each biological condition with DMVD in Maltese dogs. DNA was extracted from blood samples obtained from 48 Maltese dogs (32 with DMVD and 16 controls). Read More

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December 2018
2 Reads

Effect of Functional Mitral Regurgitation on Outcome in Patients Receiving Cardiac Resynchronization Therapy for Heart Failure.

Am J Cardiol 2019 Jan 26;123(1):75-83. Epub 2018 Sep 26.

Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

Functional mitral regurgitation (FMR) is common in heart failure (HF), and negatively impacts prognosis. Cardiac resynchronization therapy (CRT) can improve FMR, but the long-term changes in and impact of FMR after CRT are still unclear. The present study investigated the prevalence, evolution and impact on mortality of FMR before and after CRT in patients with HF. Read More

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January 2019

Cardiac valve calcification and use of anticoagulants: Preliminary observation of a potentially modifiable risk factor.

Int J Cardiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Research, Innovation and Brand Reputation, ASST Papa Giovanni XXIII, Bergamo, Italy. Electronic address:

Aims: Direct oral anticoagulant (DOAC) has been recently introduced in the clinical practice. Rather than interfering with vitamin K-dependent posttranscriptional modification of various proteins, DOACs selectively inhibit factors involved in the coagulation cascade. In particular, in contrast with Warfarin, Rivaroxabn does not interfere with activation of matrix Gla Protein (MGP), a potent vascular calcification Inhibitor. Read More

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November 2018

Transcatheter mitral valve repair using the MitraClip: which patients benefit most?

Wien Klin Wochenschr 2018 Dec;130(23-24):692-693

Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

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December 2018

Association between coronary tortuosity and mitral annular calcification.

Cardiovasc J Afr 2018 Nov 30;29:1-4. Epub 2018 Nov 30.

Department of Paediatric Cardiology, Near East University Hospital, Nicosia, Cyprus.

Introduction: Coronary tortuosity (CorT) is a common coronary angiographic finding. The aetiology, clinical implication and long-term prognosis are not well clarified. Mitral annular calcification (MAC) is one of the most common cardiac structural abnormalities on echocardiographic examination. Read More

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November 2018
2 Reads

A rare cause of ischemic stroke: cardiac myxoma. Case report and review of literature.

Rom J Morphol Embryol 2018 ;59(3):903-909

Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, Romania;

A 46-year-old female diagnosed several years ago with arterial hypertension and an ischemic stroke with significant recovery was admitted for dyspnea on usual physical activity and fatigue. Physical examination revealed signs of heart failure with crackles on both lung bases, distented jugular veins, accentuated pulmonic valve closure (P2) and tricuspid regurgitation murmur. Echocardiography identified a large tumor in the left atrium, suggestive of atrial myxoma, which caused a severe functional mitral stenosis and produced severe pulmonary hypertension. Read More

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January 2018

Pre-operative right ventricular echocardiographic parameters associated with short-term outcomes and long-term mortality after CABG.

Echo Res Pract 2018 Dec;5(4):155-166

Division of Cardiovascular Medicine, University of Toledo Medical Center, Toledo, Ohio, USA.

Background This analysis aims to assess the prognostic value of pre-operative right ventricular echocardiographic parameters in predicting short-term adverse outcomes and long-term mortality after coronary artery bypass graft (CABG). Methods Study design: Observational retrospective cohort. Pre-operative echocardiographic data, perioperative adverse outcomes (POAO) and long-term mortality were retrospectively analyzed in 491 patients who underwent isolated CABG at a single academic center between 2006 and 2014. Read More

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December 2018
1 Read

[Cardiomegalia gigante].

Gac Med Mex 2018 ;154(6):727-728

Universidad de Castilla-La Mancha, Hospital General Universitario de Albacete; Centro de Salud de Villanueva de la Jara. Castilla-La Mancha, España.

Eighty-year old woman with a medical history of arterial hypertension, rheumatic valvular heart disease with mitral and aortic valve replacement, chronic atrial fibrillation and congestive heart failure dependent on domiciliary chronic oxygen for 17 daily hours. The reason for arrival to the hospital was a stroke of cardioembolic etiology. Read More

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January 2018

Acute Mitral Regurgitation of Unknown Etiology Associated with Disseminated Intravascular Coagulation Eventually Diagnosed as Enterococcus Faecalis Infective Endocarditis by Mitral Valve Surgery.

Am J Case Rep 2018 Dec 11;19:1467-1473. Epub 2018 Dec 11.

Department of General Medicine, Saga University Hospital, Saga City, Saga, Japan.

BACKGROUND Infective endocarditis is prevalent worldwide and the modified Duke criteria have been used universally to diagnose this condition. However, making the correct diagnosis is rather difficult because the clinical presentation and findings of blood tests are non-specific. CASE REPORT A 70-year-old female complaining of dyspnea for 5 days with acute mitral regurgitation was transferred to our hospital. Read More

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December 2018

Submitral Aneurysm: an unusual aneurysm of the left ventricle.

Ann Thorac Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Anesthesia, Shahid Gangalal National Heart Center, Kathmandu, Nepal; Department of Anesthesia, Nepal Mediciti, Lalitpur, Nepal.

We report a case of 42-year-old male with submitral aneurysm presenting to the emergency room in circulatory collapse with left ventricular obstruction and severe mitral valve stenosis and regurgitation due to the aneurysm. Resection of the aneurysm along with mitral valve replacement was done through a median sternotomy without any complication and good results. Read More

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December 2018
1 Read

A deep learning based method for large-scale classification, registration, and clustering of in-situ hybridization experiments in the mouse olfactory bulb.

J Neurosci Methods 2018 Dec 6;312:162-168. Epub 2018 Dec 6.

Bates College, Program in Neuroscience, Lewiston, ME 04240, United States. Electronic address:

Background: The Allen Mouse Brain Atlas allows study of the brain's molecular anatomy at cellular scale, for thousands genes. To fully leverage this resource, one must register histological images of brain tissue - a task made challenging by the brain's structural complexity and heterogeneity, as well as inter-experiment variability.

New Method: We have developed a deep-learning based methodology for classification and registration of thousands of sections of brain tissue, using the mouse olfactory bulb (OB) as a case study. Read More

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December 2018

Diagnostic Value of Three-Dimensional Echocardiography in the Assessment of a Stenotic Caged-Ball Mitral Valve Prosthesis.

Authors:
Michael Essandoh

J Cardiothorac Vasc Anesth 2018 Sep 25. Epub 2018 Sep 25.

Department of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, OH.

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September 2018

Impact of the Cox-Maze IV Procedure on Left Atrial Mechanical Function.

Heart Lung Circ 2018 Nov 30. Epub 2018 Nov 30.

St Vincent's Hospital, Melbourne, Victoria, Australia.

Background: The Cox-Maze IV procedure is a proven surgical treatment for atrial fibrillation (AF). Previous studies on the procedure and its effect on left atrial mechanical function have yielded mixed results.

Methods: Sixty-four patients underwent Cox-Maze IV at St Vincent's Hospital, Melbourne between March 2010 and May 2016. Read More

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November 2018

Cardiac papillary fibroelastoma: Report of a surgical series.

Rev Port Cardiol 2018 Dec 7. Epub 2018 Dec 7.

Cardiothoracic Surgery Department, Centro Hospitalar de São João, Porto, Portugal.

Introduction: Papillary fibroelastoma (PFE) is a rare primary benign tumor of cardiac origin that predominantly affects the cardiac valves. Although most patients are asymptomatic, serious complications may result given their propensity for embolization. Advances in imaging technology have enabled earlier detection and more accurate characterization of these tumors. Read More

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December 2018

Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease.

Int J Infect Dis 2018 Dec 5. Epub 2018 Dec 5.

Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Brazil; Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil; Instituto Nacional de Ciência e Tecnologia em Investigação em Imunologia (iii-INCT), São Paulo, Brazil.

Background: The immunological and clinical impact of trypanocidal treatment in chronic Chagas' disease (CCD) is unclear.

Methodology And Findings: Several cytokines were measured in plasma of 66 patients with CCD. Thirty-three patients had been previously treated with benznidazole and 33 had never been treated. Read More

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December 2018

Simultaneous Enterococcus faecalis mitral valve endocarditis, mycotic aortoiliac, and intracranial aneurysms: A surgical dilemma.

J Thorac Cardiovasc Surg 2018 Oct 23. Epub 2018 Oct 23.

Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia; Vascular Surgical Unit, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

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October 2018

Usefulness of the Echocardiographic Calcium Score to Refine Risk of Major Adverse Cardiovascular Events Beyond the Traditional Framingham Risk Score.

Am J Cardiol 2018 Oct 19. Epub 2018 Oct 19.

Albert Einstein Medical Center, Division of Cardiology, Philadelphia, Pennsylvania.

Echocardiographic calcifications are associated with major adverse cardiovascular events (MACE). A recently described semiquantitative Global Cardiac Calcium Score (GCCS) has been associated with mortality and stroke, with increasing scores associated with increasing risk. This score assigns points for calcium in the aortic root and valve, mitral valve and annulus, and submitral apparatus, with additional points for restricted leaflet mobility. Read More

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October 2018

Three-dimensional mitral valve structure in predicting moderate ischemic mitral regurgitation improvement after coronary artery bypass grafting.

J Thorac Cardiovasc Surg 2018 Sep 29. Epub 2018 Sep 29.

Department of Cardiothoracic Surgery, Huashan Hospital of Fudan University, Shanghai, China. Electronic address:

Objective: Focusing on 3-dimensional mitral valve structure, this study investigated predictors for moderate ischemic mitral regurgitation (IMR) improvement after off-pump coronary artery bypass grafting (OPCAB).

Methods: This study included 143 patients (age 67.6 ± 7. Read More

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September 2018

Comprehensive and Integrative Experimentation Setup for Large Animal Hybrid Valvular Heart Surgery.

J Surg Res 2019 Feb 12;234:249-261. Epub 2018 Oct 12.

Department of Cardiac, Thoracic and Vascular Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; National University Hospital, National University Health System, Singapore.

Background: Experimental surgical procedures for atrioventricular valves present promising translational capabilities, and preclinical studies are necessary to assess their applicability and to train young enthusiastic heart teams. Here, we present a synopsis of experimental surgical procedures on porcine models for mitral valvular (MV) and tricuspid valvular (TV) interventions; mitral valve-in-valve implantation (MViV), transapical cardioscopic (TAC) MV replacement (MVR), TAC-MV annuloplasty, and tricuspid valve-in-a-ring (TViR) procedures.

Methods: Twenty-five (n = 25) female Yorkshire pigs of 55-65 kg is the total number used in the four approaches; seven animals underwent MViV, six TAC-MVR, six TAC-MV annuloplasty, and six TViR, respectively. Read More

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February 2019

MitraClip After Disinsertion of a Prosthetic Mitral Ring.

Can J Cardiol 2018 Dec 17;34(12):1688.e25-1688.e27. Epub 2018 Sep 17.

Department of Medical Specialties, Cardiology Division, University Hospitals of Geneva, Geneva, Switzerland.

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December 2018

Double-Valve Surgery After Cardiac Retransplantation.

Can J Cardiol 2018 Dec 29;34(12):1687.e1-1687.e2. Epub 2018 Sep 29.

Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. Electronic address:

We provide an update on Canada's first neonatal heart transplant recipient who, after cardiac retransplantation, underwent a mitral valve replacement and tricuspid valve repair. Twenty-seven years after his initial heart surgery and 13 years after his most recent transplant, this patient developed heart failure with severe mitral regurgitation secondary to a calcified mitral valve. The patient was highly sensitized with no evidence of allograft rejection; therefore, mitral and tricuspid surgery was performed. Read More

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December 2018

The Value of Claims-Based Nontraditional Risk Factors in Predicting Long-term Mortality After MitraClip Procedure.

Can J Cardiol 2018 Dec 13;34(12):1648-1654. Epub 2018 Oct 13.

Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Beth Israel Deaconess Medical Center. Electronic address:

Background: We sought to identify nontraditional risk factors coded in administrative claims data and evaluate their ability to improve prediction of long-term mortality in patients undergoing percutaneous mitral valve repair.

Methods: Patients undergoing transcatheter mitral valve repair using MitraClip implantation between September 28, 2010, and September 30, 2015 were identified among Medicare fee-for-service beneficiaries. We used nested Cox regression models to identify claims codes predictive of long-term mortality. Read More

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December 2018