Circulation 2022 Jun 9. Epub 2022 Jun 9.
Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sweden; Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, University of Gothenburg, Sweden; The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden; Department of Clinical Physiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Swede.
Background: The role of diabetes in the development of valvular heart disease and particularly the relation with risk factor control, has not been extensively studied.
Methods: We included 715,143 patients with diabetes registered in the Swedish National Diabetes Register and compared them with 2,732,333 matched controls randomly selected from the general population. Trends were analyzed with incidence rates and Cox regression, which was also used to assess diabetes as a risk factor compared to controls, and, second, separately in patients with diabetes according to the presence of five risk factors. Read More