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    30118 results match your criteria Mitral Regurgitation

    1 OF 603

    Outcomes in anticoagulated patients with atrial fibrillation and with mitral or aortic valve disease.
    Heart 2018 Jan 19. Epub 2018 Jan 19.
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.
    Objective: To assess stroke/systemic embolism, major bleeding and other outcomes, and treatment effect of apixaban versus warfarin, in patients with atrial fibrillation (AF) and different types of valvular heart disease (VHD), using data from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial.

    Methods: There were 14 793 patients with known VHD status, categorised as having moderate or severe mitral regurgitation (MR) (n=3382), aortic regurgitation (AR) (n=842) or aortic stenosis (AS) (n=324); patients with moderate or severe mitral stenosis were excluded from the trial. Baseline characteristics, efficacy and safety outcomes were compared between each type and no significant VHD. Read More

    Reversibility of severe mitral valve regurgitation after left ventricular assist device implantation: single-centre observations from a real-life population of patients.
    Eur J Cardiothorac Surg 2018 Jan 16. Epub 2018 Jan 16.
    Department of Cardiac Surgery, University of Leipzig, Leipzig Heart Center, Leipzig, Germany.
    Objectives: This study evaluates the impact of untreated preoperative severe mitral valve regurgitation (MR) on outcomes after left ventricular assist device (LVAD) implantation.

    Methods: Of the 234 patients who received LVAD therapy in our centre during a 6-year period, we selected those who had echocardiographic images of good quality and excluded those who underwent mitral valve replacement prior to or mitral valve repair during LVAD placement. The 128 patients selected were divided into 2 groups: Group A with severe MR (n = 65) and Group B with none to moderate MR (n = 63, 28 with moderate MR). Read More

    Assessment of mitral annulus and mitral leaflet in nonvalvular atrial fibrillation patients with various degrees of mitral regurgitation: Real time 3D transesophageal echocardiography.
    Echocardiography 2018 Jan 19. Epub 2018 Jan 19.
    Department of Ultrasound, Tianjin Chest Hospital, Tian Jin, China.
    Aim: To study the changes of mitral valve (MV) in patients with nonvalvular atrial fibrillation (NVAF)-related mitral regurgitation (MR) and the relationship between MV parameters and the enlarged left atrium (LA).

    Materials And Methods: A total of 43 patients with NVAF were divided into two groups: (1) the MR1 group with mild MR and (2) the MR2 group with moderate-to-severe MR. Real time 3D transesophageal echocardiography (TEE) was performed to detect the structure of MV. Read More

    An extensive caseous calcification of the mitral annulus complicated with severe mitral regurgitation.
    Echocardiography 2018 Jan 18. Epub 2018 Jan 18.
    Department of Cardiology, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey.
    Caseous calcification of the mitral annulus (CCMA) is considered a rare variant of mitral annular calcification (MAC) due to caseous transformation of the inner material and prevalence of CCMA, about 0.63% of all MAC cases and 0.06%-0. Read More

    Tricuspid regurgitation in acute heart failure: is there any incremental risk?
    Eur Heart J Cardiovasc Imaging 2018 Jan 15. Epub 2018 Jan 15.
    Department of Cardiology, Rambam Medical Center, and B. Rappaport Faculty of Medicine, Technion Medical School, POB 9602, Haifa 31096, Israel.
    Aim: Significant tricuspid regurgitation (TR) is common in heart failure (HF) and portends poor prognosis. We sought to determine whether the poor outcome results from the TR itself, or whether the TR is a surrogate marker of advanced left-sided myocardial or valvular heart disease.

    Methods And Results: We studied 639 patients admitted for acute HF. Read More

    Catheter-based edge-to-edge mitral valve repair for pulmonary pressure reduction and to postpone heart transplantation in a teenaged patient.
    ESC Heart Fail 2018 Jan 18. Epub 2018 Jan 18.
    Clinical Division of Cardiology and Angiology, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria.
    We report a case of catheter-based edge-to-edge mitral valve repair in a teenage male patient with non-ischaemic cardiomyopathy to improve pulmonary hypertension secondary to severe functional mitral regurgitation (FMR) to defer anticipated heart transplantation. A 19-year-old patient with previous history of fulminant myocarditis followed by markedly left ventricular dysfunction presented with severe mitral regurgitation 3 years after initial recovery. Slightly over time, deterioration of FMR was associated with gradual increase in pulmonary artery pressures despite optimal medical therapy. Read More

    Prognosis of patients with secondary mitral regurgitation and reduced ejection fraction.
    Open Heart 2018 9;5(1):e000745. Epub 2018 Jan 9.
    Cardiology, Harvard Medical School, Boston, Massachusetts, USA.
    Objective: The impact of the severity of secondary mitral regurgitation (MR) on the risk of death and heart failure (HF) hospitalisations in patients with reduced left ventricular (LV) systolic function is poorly defined. The study sought to identify the incremental risk of secondary MR in patients with reduced LV systolic function.

    Methods: We studied 615 consecutive patients with LV ejection fraction ≤35% by transthoracic echocardiography at a single medical centre. Read More

    Clinical profile of patients with heart failure can predict rehospitalization and quality of life.
    J Cardiovasc Med (Hagerstown) 2018 Jan 15. Epub 2018 Jan 15.
    Department of Cardiology, Cardiovascular Disease, University of L'Aquila, L'Aquila.
    Background: The aim of this retrospective study was to identify clinical, humoral and echocardiographic variables predicting rehospitalization and poor quality of life (QOL) in patients with reduced or mid-range ejection fraction heart failure.

    Methods: From 2009 to 2012, 310 patients were admitted having signs and symptoms of heart failure with reduced ejection fraction. All the patients were followed by phone, calling the patients or the referring general practitioner. Read More

    Early and long-term outcomes of mitral valve repair for Barlow's disease: a single-centre 16-year experience.
    Interact Cardiovasc Thorac Surg 2018 Jan 10. Epub 2018 Jan 10.
    Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, Netherlands.
    Objectives: Following mitral valve repair for Barlow's disease, recurrent mitral regurgitation (MR) is believed to occur frequently and is mainly attributed to disease progression.

    Methods: Between January 2000 and December 2015, 180 patients (40% women, mean age 58.7 ± 13. Read More

    Mitral valve replacement via a left thoracotomy in dextrocardia and situs solitus.
    Asian Cardiovasc Thorac Ann 2018 Jan 1:218492318755180. Epub 2018 Jan 1.
    1 Department of Cardiovascular Surgery, 16811 Coruna University Hospital , Coruna, Spain.
    Dextrocardia with situs solitus and severe mitral regurgitation is a rare clinical presentation which posse a surgical challenge and requires specific preoperative planning. A 54-year-old women with this anatomy, multiple thoracic procedures, and severe mitral valve regurgitation underwent successful mitral valve replacement with a 27-mm mechanical prosthesis through a left thoracotomy under ventricular fibrillation, on the basis of computed tomography findings. We emphasize the importance of preoperative planning and a surgical approach through a left thoracotomy and under ventricular fibrillation. Read More

    Large inferolateral left ventricular aneurysm.
    Ann Card Anaesth 2018 Jan-Mar;21(1):68-70
    Department of Cardiothoracic Surgery and Anesthesiology, Uppsala University Hospital, Uppsala, Sweden.
    The majority of cardiac left ventricular aneurysms involve the anterior and/or apical wall. We present a case of a 50-year-old man with heart failure caused by a large inferolateral left ventricular aneurysm and associated mitral regurgitation, managed by aneurysmectomy, mitral valvuloplasty, and surgical revascularization. Read More

    Rare Combination of Pathologies Causing Mitral Stenosis and Mitral Regurgitation: A Case Report.
    World J Pediatr Congenit Heart Surg 2018 Jan 1:2150135117743224. Epub 2018 Jan 1.
    1 Department of Pediatric Cardiology, Fortis-ESCORT Heart Institute, New Delhi, India.
    A supramitral ring is a rare cause of mitral stenosis, while an isolated mitral valve cleft is a rare cause of congenital mitral regurgitation. Fortunately, both the lesions are known to have good outcomes after surgical correction. Although each is known to be associated with a variety of other structural heart defects, their coexistence has not been reported previously. Read More

    Practical valvular issues in patients requiring ventricular assist devices.
    Curr Opin Cardiol 2018 Jan 13. Epub 2018 Jan 13.
    Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network.
    Purpose Of Review: As ventricular assist device (VAD) therapy in patients with advanced heart failure continues to grow, experience with concomitant valvular diseases present either before or after VAD implantation continues to accrue. In this review, we discuss recent data and current practice as it pertains to the subject of concomitant valvular disease in patients requiring VADs.

    Recent Findings: Persistent aortic valve closure has been identified as a potential contributor to aortic valve 'disuse atrophy' resulting in valve degeneration. Read More

    Mitral Valve Anatomic Predictors of Hemodynamic Success With Transcatheter Mitral Valve Repair.
    J Am Heart Assoc 2018 Jan 13;7(2). Epub 2018 Jan 13.
    Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
    Background: Mitral regurgitation is a heterogeneous disease. Determining which patients derive optimal outcomes from transcatheter edge-to-edge mitral valve repair (TMVR) remains challenging. We sought to determine whether baseline mitral valve anatomic characteristics are predictive of left atrial pressure (LAP) changes during TMVR with MitraClip. Read More

    Mechanisms of changes in functional mitral regurgitation by preload alterations.
    J Cardiol 2018 Jan 10. Epub 2018 Jan 10.
    Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Okayama, Japan.
    Background: This study aimed to investigate the mechanisms of acute changes in functional mitral regurgitation (FMR) by preload alterations.

    Methods: Twenty-two consecutive patients with left ventricular ejection fraction <40% and at least mild FMR underwent transthoracic echocardiography. Passive leg lifting and sublingual administration of nitroglycerin were performed to alter preload. Read More

    Hospital Outcome and Risk Indices of Mortality in Potential Candidates for Transcatheter Procedures: Results From a European Registry.
    J Cardiothorac Vasc Anesth 2017 Sep 28. Epub 2017 Sep 28.
    Division of Cardiac Surgery, University of Verona, Verona, Italy.
    Objective: Transcatheter mitral valve-in-valve/valve-in-ring procedures (TM-VIVoR) are increasing. The authors aimed to identify independent predictors for hospital mortality in redo mitral valve surgery as possible future selection criteria for TM-VIVoR.

    Design: Retrospective multicenter registry. Read More

    Tricuspid and Mitral Valve Regurgitation with Bi-fascicular Block Following a Horse Kick.
    Intern Med 2018 Jan 11. Epub 2018 Jan 11.
    Department of Cardiovascular Medicine, Fukushima Medical University, Japan.
    A 40-year-old man was transferred to our hospital following an isolated horse kick injury to the anterior chest wall. The case showed bi-fascicular block, severe tricuspid valve regurgitation due to ruptured chordae tendineae of the anterior leaflet, moderate mitral valve regurgitation due to prolapse of mitral anterior leaflet, and hypokinetic motion of the inferior septal wall. Both tricuspid and mitral insufficiency were completely repaired by a surgical operation. Read More

    Prognostic Value of Right Ventricular Dysfunction in Heart Failure With Reduced Ejection Fraction: Superiority of Longitudinal Strain Over Tricuspid Annular Plane Systolic Excursion.
    Circ Cardiovasc Imaging 2018 Jan;11(1):e006894
    From the Division of Cardiology, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia, Perugia, Italy.
    Background: In heart failure (HF) with reduced ejection fraction, right ventricular (RV) impairment, as defined by reduced tricuspid annular plane systolic excursion, is a predictor of poor outcome. However, peak longitudinal strain of RV free wall (RVFWS) has been recently proposed as a more accurate and sensitive tool to evaluate RV function. Accordingly, we investigated whether RVFWS could help refine prognosis of patients with HF with reduced ejection fraction in whom tricuspid annular plane systolic excursion is still preserved. Read More

    Pathophysiology of Degenerative Mitral Regurgitation: New 3-Dimensional Imaging Insights.
    Circ Cardiovasc Imaging 2018 Jan;11(1):e005971
    From the Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN (C.A., F.M., G.B., S.V.M., J.F.M., H.I.M., M.E.-S.); and Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy (F.M.).
    Despite its high prevalence, little is known about mechanisms of mitral regurgitation in degenerative mitral valve disease apart from the leaflet prolapse itself. Mitral valve is a complex structure, including mitral annulus, mitral leaflets, papillary muscles, chords, and left ventricular walls. All these structures are involved in physiological and pathological functioning of this valvuloventricular complex but up to now were difficult to analyze because of inherent limitations of 2-dimensional imaging. Read More

    Exercise Hemodynamic and Functional Capacity After Mitral Valve Replacement in Patients With Ischemic Mitral Regurgitation: A Comparison of Mechanical Versus Biological Prostheses.
    Circ Heart Fail 2018 Jan;11(1):e004056
    >From the Cardiovascular Department, Ospedale Papa Giovanni XXIII, Bergamo, Italy (C.F., A.I., P.F., M.M., L.G., P.F., D.C., M.S.); Hypertrofic Cardiomyopathy Centre, Policlinico di Monza, Monza, Italy (P.F.); Québec Heart & Lung Institute, Department of Medicine, Laval University, Quebec City, QC, Canada (P.P.); Department of Cardiothoracic Surgery, Royal Brompton and Harefield Hospital, London, United Kingdom (J.R.P.); Bristol Royal Infirmary, University of Bristol, United Kingdom (M.C.); Surgical Skills Centre, Manchester Science Park, United Kingdom (C.A.); Division of Cardiovascular Diseases, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Palermo, Italy (D.B.); and CHU Limoges, Hôpital Dupuytren, Service Cardiologie, France (J.M.).
    Background: In patients with ischemic mitral regurgitation requiring mitral valve replacement (MVR), the choice of the prosthesis type is crucial. The exercise hemodynamic and functional capacity performance in patients with contemporary prostheses have never been investigated. To compare exercise hemodynamic and functional capacity between biological (MVRb) and mechanical (MVRm) prostheses. Read More

    Long-Term Mortality in Patients with Severe Secondary Mitral Regurgitation and Normal Left Ventricular Ejection Fraction: Interventional Perspective.
    EuroIntervention 2018 Jan 9. Epub 2018 Jan 9.
    Department of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
    Aims: Patients with severe secondary mitral regurgitation (MR) and normal ejection fraction are being excluded from clinical trials evaluating transcatheter mitral devices. We sought to evaluate the long-term mortality with medical management alone in this patient population.

    Methods And Results: We retrospectively evaluated patients diagnosed with ≥3+ mitral MR at our institution over 15 years. Read More

    Alfieri stitch for temporary severe functional mitral regurgitation after aortic valve replacement.
    Surg Case Rep 2018 Jan 8;4(1). Epub 2018 Jan 8.
    Department of Cardiovascular Surgery, Awaji Medical Center, Hyogo, Japan.
    The outcome in functional mitral regurgitation after aortic valve replacement is unclear. A frail 82-year-old woman with severe aortic valve regurgitation and mild to moderate functional mitral valve regurgitation (NYHA functional class III) was referred to our clinic. In consideration of her frail condition, aortic valve replacement without mitral surgery was performed. Read More

    Imaging 4D morphology and dynamics of mitral annulus in humans using cardiac cine MR feature tracking.
    Sci Rep 2018 Jan 8;8(1):81. Epub 2018 Jan 8.
    National Heart Research Institute Singapore, National Heart Centre, Singapore, 5 Hospital Drive, 169609, Singapore.
    Feature tracking in cine cardiac magnetic resonance (CMR) is a quantitative technique to assess heart structure and function. We investigated 4-dimensional (4D) dynamics and morphology of the mitral annulus (MA) using a novel tracking system based on radially rotational long-axis cine CMR series. A total of 30 normal controls and patients with mitral regurgitation were enrolled. Read More

    3D vena contracta area after MitraClip© procedure: precise quantification of residual mitral regurgitation and identification of prognostic information.
    Cardiovasc Ultrasound 2018 Jan 9;16(1). Epub 2018 Jan 9.
    Department of Internal Medicine II, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, D-93053, Regensburg, Germany.
    Background: Percutaneous mitral valve repair (PMVR) is increasingly performed in patients with severe mitral regurgitation (MR). Post-procedural MR grading is challenging and an unsettled issue. We hypothesised that the direct planimetry of vena contracta area (VCA) by 3D-transoesophageal echocardiography allows quantifying post-procedural MR and implies further prognostic relevance missed by the usual ordinal scale (grade I-IV). Read More

    Causes of repair failure for degenerative mitral valve disease and reoperation outcomes.
    Eur J Cardiothorac Surg 2018 Jan 3. Epub 2018 Jan 3.
    Department of Cardiovascular Surgery, Sakakibara Heart Institute, Tokyo, Japan.
    Objectives: This study aimed to evaluate the causes of initial mitral valve (MV) repair failure, the details of reoperation and the long-term outcomes of mitral valve re-repair (Re-MVP).

    Methods: We retrospectively reviewed 86 patients who underwent reoperation after MV repair for MR due to degenerative disease from October 1991 to December 2015. First, we analysed the initial MV repair data, causes of MV repair failure, reoperation data and long-term outcomes including survival. Read More

    Calculation of Mitral Valve Area in Mitral Stenosis: Comparison of Continuity Equation and Pressure Half Time With Two-Dimensional Planimetry in Patients With and Without Associated Aortic or Mitral Regurgitation or Atrial Fibrillation.
    Acta Med Iran 2017 Nov;55(11):696-704
    Department of Cardiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
    Accurate measurement of Mitral Valve Area (MVA) is essential to determining the Mitral Stenosis (MS) severity and to achieving the best management strategies for this disease. The goal of the present study is to compare mitral valve area (MVA) measurement by Continuity Equation (CE) and Pressure Half-Time (PHT) methods with that of 2D-Planimetry (PL) in patients with moderate to severe mitral stenosis (MS). This comparison also was performed in subgroups of patients with significant Aortic Insufficiency (AI), Mitral Regurgitation (MR) and Atrial Fibrillation (AF). Read More

    Adverse impact of diabetes mellitus on left ventricular remodelling in patients with chronic primary mitral regurgitation.
    Arch Cardiovasc Dis 2018 Jan 3. Epub 2018 Jan 3.
    Cardiac Ultrasound Laboratory and Cardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston MA 02114, USA; Cardiac Ultrasound Laboratory, Perelman Center for Advanced Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:
    Background: Diabetes mellitus (DM) has an impact on left ventricular (LV) geometry and function, and is associated with worsening of pressure-overload LV remodelling; however, its impact on volume-overload LV remodelling is unknown.

    Aim: The objective of the study was to examine the association between DM and LV remodelling in patients with chronic mitral regurgitation (MR) caused by mitral valve prolapse.

    Methods: During a median follow-up of 3. Read More

    Clinical Utility of Left Atrial Strain in Children in the Acute Phase of Kawasaki Disease.
    J Am Soc Echocardiogr 2018 Jan 3. Epub 2018 Jan 3.
    Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea.
    Background: We aimed to evaluate the diagnostic utility of peak left atrial longitudinal strain (PALS) during left ventricular (LV) systole to differentiate children in the acute phase of Kawasaki disease (aKD) from controls. We also aimed to compare the diagnostic utility of PALS with those of conventional echocardiographic indices of diastolic function.

    Methods: Retrospectively measured PALS, LV longitudinal peak systolic strain, and strain rate obtained via velocity vector imaging were compared in a derivation cohort comprising 95 aKD and 67 controls. Read More

    Antithrombotic Treatment after Transcatheter Heart Valves Implant.
    Semin Thromb Hemost 2018 Jan 5. Epub 2018 Jan 5.
    The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
    Transcatheter heart valve replacement technology was introduced as alternative to surgery for the growing high-risk profile population. Developed first, aortic valve replacement (TAVR) became a standard of care for patients with severe aortic stenosis at high operative risk, with a potential future use also for low-risk subjects. In the last decade, a multitude of transcatheter mitral valve replacement (TMVR) devices have been developed for the treatment of severe mitral regurgitation, with encouraging results coming from first-in-man and feasibility studies. Read More

    A New Method to Evaluate Atrial Hemodynamic and Quantify Mitral Regurgitation using Cardiovascular Magnetic Resonance: The Pulmonary Venous Flow Approach.
    J Heart Valve Dis 2017 Jul;26(4):456-459
    Section of Cardiology, Department of Medicine, University of Verona, Verona, Italy.
    Pulmonary venous flow (PVF) provides incremental information on left ventricular (LV) diastolic function, and can support the diagnosis of severe mitral regurgitation (MR). The suggestion has been made to combine the left atrial filling volume (LA Fill) and PVF for estimating the mitral regurgitant volume, but echocardiographic PVF evaluation is known to have many limitations. The present case report includes an example of how to assess PVF using cardiovascular magnetic resonance, and a new method is proposed for quantification of the mitral regurgitant volume. Read More

    Restrictive Mitral Annuloplasty With or Without Papillary Muscle Approximation for Functional Mitral Regurgitation.
    J Heart Valve Dis 2017 Jul;26(4):447-455
    Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan.
    Background: The impact of adding papillary muscle approximation (PMA) to restrictive mitral annuloplasty (RMA) on postoperative left ventricular (LV) function is unknown. Changes in LV function parameters and clinical outcome were evaluated following RMA with and without PMA in patients with clinically relevant functional mitral regurgitation (FMR).

    Methods: A total of 176 patients with advanced cardiomyopathy underwent RMA either with (n = 59) or without (n = 117) PMA. Read More

    Left Heart Ejection Fraction as a Load-Independent Parameter for Patients with Mitral Regurgitation.
    J Heart Valve Dis 2017 Jul;26(4):437-446
    Department Echocardiography, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China. Electronic correspondence:
    Background: The functions of the left ventricle and left atrium are closely associated with the outcomes of surgically treated patients with severe mitral regurgitation (MR). However, both parameters were overestimated in the presence of MR. The present study integrated the left atrium and left ventricle as the left heart (LH) to eliminate the influence of MR within the integrated structure. Read More

    Impact of Tricuspid Valve Regurgitation on Early Outcomes after Transcatheter Aortic Valve Replacement.
    J Heart Valve Dis 2017 Jul;26(4):380-385
    Newark Beth Israel Medical Center, Newark, NJ, USA.
    Background: Tricuspid valve regurgitation (TR) is often not taken into consideration in the prognostication of patients undergoing transcatheter aortic valve replacement (TAVR). Accordingly, its impact on such patients remains relatively poorly defined. The study aim was to explore the effect of TR and parameters of right ventricular (RV) function on outcomes in patients undergoing TAVR. Read More

    Echocardiographic evaluation and guidance for MitraClip procedure.
    Cardiovasc Diagn Ther 2017 Dec;7(6):616-632
    Division of Cardiovascular Diseases, Department of Medicine, UPMC Heart & Vascular Institute, University of Pittsburgh, Pittsburgh, PA, USA.
    Transcatheter mitral valve repair using the MitraClip system (Abbott, Abbott Park, Il, USA) has become a world-wide, well-established therapeutic alternative to treat symptomatic patients with severe mitral regurgitation and prohibitive surgical risk. This article offers a comprehensive review of the important clinical and imaging aspects related to the patient selection, imaging evaluation and intraprocedural guidance for optimal results using this transcatheter device therapy. This article provides an updated framework for the interested practitioners summarizing the current understanding and applications for this device based on the current literature and growing experience of this technique. Read More

    Surgical treatment of secondary mitral regurgitation: is repair a reasonable option?
    J Vis Surg 2017 7;3:158. Epub 2017 Nov 7.
    Department of Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
    Background: The optimal approach for treating secondary mitral regurgitation (MR) is debated. Since annuloplasty alone has resulted in 30% or more recurrent MR in the mid-term, recent studies suggest mitral valve replacement. However, subvalvular repair strategies as an adjunct to annuloplasty in order to prevent recurrent MR due to ongoing left ventricle (LV) remodeling are becoming increasingly popular. Read More

    Educational needs and application of guidelines in the management of patients with mitral regurgitation. A European mixed-methods study.
    Eur Heart J 2018 Jan 2. Epub 2018 Jan 2.
    AP-HP, Cardiology Department, Bichat Hospital, Paris-Diderot University, DHU Fire, 46 rue Henri Huchard, 75018 Paris, France.
    Aims: To assess the knowledge and application of European Society of Cardiology (ESC) Guidelines in the management of mitral regurgitation (MR).

    Methods And Results: A mixed-methods educational needs assessment was performed. Following a qualitative phase (interviews), an online survey was undertaken using three case scenarios (asymptomatic severe primary MR, symptomatic severe primary MR in the elderly, and severe secondary MR) in 115 primary care physicians (PCPs), and 439 cardiologists or cardiac surgeons from seven European countries. Read More

    Multimodality imaging assessment of a caseous calcification of the mitral valve annulus.
    J Saudi Heart Assoc 2018 Jan 4;30(1):55-58. Epub 2017 May 4.
    Department of Cardiology, Military Hospital of Tunis, Tunis, Tunisia.
    Caseous calcification of the mitral annulus (CCMA) is a rare echocardiographic finding. It is commonly misdiagnosed as an abscess, tumor or infective vegetation on the mitral valve. Since it is a benign process, differentiating it from malignant intra-cardiac mass is primordial to avoid unnecessary surgery. Read More

    Loeys-Dietz syndrome with aortic wall necrosis secondary to external wrapping.
    Eur J Cardiothorac Surg 2017 Dec 25. Epub 2017 Dec 25.
    Laboratory of Diagnostic Pathology, Kochi Medical School, Kochi, Japan.
    External aortic wrapping may overcompress the aortic wall. An 18-year-old man underwent valve-sparing aortic root replacement for annuloaortic ectasia caused by Loeys-Dietz syndrome. External Dacron graft wrapping was performed to protect the ascending aorta. Read More

    Effects of Transcatheter Mitral Valve Repair with MitraClip on Left Ventricular and Atrial Hemodynamic Load and Myocardial Wall Stress.
    J Card Fail 2017 Dec 29. Epub 2017 Dec 29.
    Departments of Cardiology and Cardiothoracic Surgery, Heart Lung Centre, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:
    Aims: To evaluate the effects of MitraClip on left ventricular (LV) and left atrial (LA) myocardial wall stress as assessed with N-terminal pro-brain natriuretic peptide (NT-proBNP) and strain imaging.

    Methods And Results: Sixty-five patients with symptomatic moderate and severe mitral regurgitation (MR) (age 75±9 years, 57% male, 89% functional MR) treated with MitraClip were evaluated. Patients were divided according to the 6-month NT-proBNP tertiles. Read More

    Initial experience with percutaneous edge-to-edge transcatheter mitral valve repair in a tertiary medical center in Taiwan.
    J Chin Med Assoc 2017 Dec 29. Epub 2017 Dec 29.
    Division of Cardiovascular Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan, ROC.
    Background: The transcatheter edge-to-edge mitral valve repair, using MitraClip, has been a safe and effective treatment for severe mitral regurgitation (SMR) in the westerners. However, the therapeutic results of the MitralClip in Taiwan remained elucidated.

    Methods: Patients with symptomatic SMR were evaluated by the heart team. Read More

    Serotonin receptor 2B signaling with interstitial cell activation and leaflet remodeling in degenerative mitral regurgitation.
    J Mol Cell Cardiol 2017 Dec 30;115:94-103. Epub 2017 Dec 30.
    Columbia University, New York, NY, United States. Electronic address:
    Aims: Mitral valve interstitial cells (MVIC) play an important role in the pathogenesis of degenerative mitral regurgitation (MR) due to mitral valve prolapse (MVP). Numerous clinical studies have observed serotonin (5HT) dysregulation in cardiac valvulopathies; however, the impact of 5HT-mediated signaling on MVIC activation and leaflet remodeling in MVP have been investigated to a limited extent. Here we test the hypothesis that 5HT receptors (5HTRs) signaling contributes to MVP pathophysiology. Read More

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