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    1 OF 595

    Custom extracellular matrix cylinder mitral valve in a pediatric patient.
    Echocardiography 2017 Sep 24. Epub 2017 Sep 24.
    Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.
    Mitral valve construction using extracellular matrix (ECM) is a relatively new procedure. In this case, a 15-month-old boy with a history of severe mitral valve regurgitation secondary to endocarditis underwent mitral valve surgery. Mitral valve repair was not possible, and thus, a 17 mm extracellular matrix cylinder valve (ECM-CV) was constructed for valve replacement. Read More

    Transcatheter mitral valve replacement: device landscape and early results.
    EuroIntervention 2017 Sep;13(AA):AA31-AA39
    Center for Interventional and Vascular Therapy, Columbia University Medical Center, New York, NY, USA.
    Mitral regurgitation (MR) is the second most common valvular heart disease in the western world with a prevalence in the USA alone of two to four million people. MR is age-dependent and hence the MR burden is expected to increase with the increase in life expectancy observed in Europe and the USA. Medical and surgical treatment has been the cornerstone of the treatment as untreated MR results in poor prognosis. Read More

    Mitral valve: repair/clips/cinching/chordae.
    EuroIntervention 2017 Sep;13(AA):AA22-AA30
    Cardiology Department, University Paris Diderot, Bichat Hospital, AP-HP, Paris, France.
    The treatment of mitral regurgitation has changed in recent years due to the advent of interventional techniques, mostly the percutaneous edge-to-edge repair, and, more recently, annuloplasty and chordal replacement. In the future, more advances are expected from further development of interventional techniques, careful evaluation and better patient selection. Read More

    Impact of Left Ventricular vs Biventricular Pacing on Reverse Remodelling: Insights From the Evaluation of Resynchronization Therapy for Heart Failure (EARTH) Trial.
    Can J Cardiol 2017 Oct 31;33(10):1274-1282. Epub 2017 Jul 31.
    Department of Medicine, Montreal Heart Institute, Montreal, Québec, Canada. Electronic address:
    Background: Studies comparing biventricular (BiV) cardiac resynchronization therapy (CRT) and left ventricular (LV) pacing alone have yielded conflicting results. We recently reported the results of the Greater Evaluation of Resynchronization Therapy for Heart Failure (GREATER-EARTH) trial demonstrating similar clinical benefits of BiV and LV-CRT on exercise tolerance. We report the prespecified secondary outcomes of the GREATER-EARTH trial, comparing the impact of BiV vs LV-CRT on structural and biochemical cardiac remodelling. Read More

    Surgical Outcomes of Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery in Children: An Echocardiography Follow-up.
    Chin Med J (Engl) 2017 Oct;130(19):2333-2338
    Heart Center, Children's Hospital of Fudan University, Shanghai 201102, China.
    Background: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare but potentially life-threatening congenital heart defect. A retrospective analysis was carried out to elucidate the surgical outcomes of ALCAPA in infants and children using follow-up echocardiography.

    Methods: From September 2008 to March 2017, 26 children diagnosed with ALCAPA underwent left coronary re-implantation. Read More

    Factors Related to Ventricular Size and Valvular Regurgitation in Healthy Tibetans in Lhasa.
    Chin Med J (Engl) 2017 Oct;130(19):2316-2320
    Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China.
    Background: Lhasa is the main residence of Tibetans and one of the highest cities in the world. Its unique geography and ethnic population provide the chance to investigate the interactions among high altitude, ethnicity, and cardiac adaptation. Meanwhile, echocardiographic data about healthy Tibetans on a large scale are not available. Read More

    Echocardiographic Screening of Rheumatic Heart Disease in American Samoa.
    Pediatr Cardiol 2017 Sep 20. Epub 2017 Sep 20.
    Division of Pediatric Cardiology, Oregon Health and Science University, CDRC-P, 707 SW Gaines St., Portland, OR, 97239, USA.
    While rheumatic heart disease (RHD) is a treatable disease nearly eradicated in the United States, it remains the most common form of acquired heart disease in the developing world. This study used echocardiographic screening to determine the prevalence of RHD in children in American Samoa. Screening took place at a subset of local schools. Read More

    Acute reverse annular remodeling during MitraClip(®) therapy predicts improved clinical outcome in heart failure patients: a 3D echocardiography study.
    Eur J Med Res 2017 Sep 20;22(1):33. Epub 2017 Sep 20.
    Department of Medicine, Division of Cardiology, Pneumology, and Angiology, University Hospital Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.
    Background: Transcatheter mitral valve repair (TMVR) has been shown to have acute effects on mitral valve geometry in patients with functional mitral regurgitation (FMR). This study investigates the impact of MitraClip(®) therapy-induced annular remodeling on clinical outcome and mitral regurgitation in heart failure patients.

    Methods: TMVR was performed successfully in 45 patients with FMR. Read More

    Transcatheter Mitral Valve Replacement of NaviGate Bioprosthesis in A Preclinical Model.
    EuroIntervention 2017 Sep 19. Epub 2017 Sep 19.
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH, USA.
    Aims: To test the feasibility of trans-catheter mitral valve implantation of the NaviGate device in acute and chronic preclinical models.

    Methods And Results: We evaluated the NaviGate valved stent implantation in the mitral position in an acute swine model (n=24, ≤ 5 days) through three different approaches: trans-atrial, trans-apical, and trans-septal, and in a chronic swine model (n=12, >10 days) through a trans-atrial approach. The NaviGate implantation procedures were successful in 83% of the acute model studies (n=20) and 83% of the chronic model studies (n=10). Read More

    Politetrafluorene suture used as artificial mitral chord: mechanical properties and surgical implications.
    J Cardiovasc Surg (Torino) 2017 Dec;58(6):895-903
    Department of Health Sciences, University Eastern Piedmont, UPO, Novara, Italy.
    Background: Novel surgical approach to repair degenerative mitral regurgitation such as transapical chordae tendineae replacement and "loop in loop" in loop techniques, need of artificial chordae longer than that used in the older techniques of chordae tendineae replacement. This difference in length has been reported as potential critical point for durability of artificial chordae. In the present paper we have investigated the elastic behavior of different diameter and length politetrafluorene (PTFE) suture threads as substitute of native chordae, to identify their reliability to use as long artificial chordae. Read More

    Left Ventricular False Tendons are Associated With Left Ventricular Dilation and Impaired Systolic and Diastolic Function.
    Am J Med Sci 2017 Sep 26;354(3):278-284. Epub 2017 May 26.
    Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
    Background: Left ventricular false tendons (LVFTs) are chord-like structures that traverse the LV cavity and are generally considered to be benign. However, they have been associated with arrhythmias, LV hypertrophy and LV dilation in some small studies. We hypothesize that LVFTs are associated with LV structural and functional changes assessed by echocardiography. Read More

    Anatomic Repair of Congenitally Corrected Transposition of the Great Arteries: Single-Center Intermediate-Term Experience.
    Pediatr Cardiol 2017 Sep 16. Epub 2017 Sep 16.
    Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.
    We present our experience for patients who have undergone an anatomic repair (AR) for congenitally corrected transposition of the great arteries (CCTGA) at the Children's Hospital of Wisconsin. A retrospective chart review of patients who underwent AR for CCTGA from 2001 to 2015 was performed. The cohort consisted of 15 patients (74% male). Read More

    Preoperative assessment of mitral valve abnormalities in left atrial myxoma patients using cardiac CT.
    Oncotarget 2017 Aug 11;8(34):57583-57593. Epub 2017 Mar 11.
    Department of Radiology, West China Second University Hospital, Sichuan University, China.
    Background: To retrospectively evaluate mitral valve abnormality in left atrial myxoma patients by using cardiac computed tomography (CT).

    Material And Methods: Cardiac CT was performed in 56 patients with left atrial myxoma and 50 controls. Tumor and mitral valve characteristics were analyzed. Read More

    The changing spectrum of rheumatic mitral regurgitation in Soweto, South Africa.
    Cardiovasc J Afr 2017 Jul/Aug;28(4):215-220
    Department of Cardiology Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.
    Objectives: To determine the clinical and echocardiographic characteristics of contemporary patients with rheumatic mitral regurgitation (MR) at Chris Hani Baragwanath Academic Hospital.

    Methods: This prospective, cross-sectional study included 84 patients with isolated moderate or severe rheumatic MR who underwent clinical and echocardiographic assessment.

    Results: Mean age of the patients was 44 ± 15. Read More

    Mitral regurgitation in patients with severe aortic stenosis: diagnosis and management.
    Heart 2017 Sep 13. Epub 2017 Sep 13.
    Baylor University Medical Center, Baylor Heart and Vascular Hospital, Dallas, Texas, USA.
    Severe aortic stenosis (AS) and mitral regurgitation (MR) frequently coexist. Although some observational studies have reported that moderate or severe MR is associated with higher mortality, the optimal management of such patients is still unclear. Simultaneous replacement of both aortic and mitral valves is linked to significantly higher morbidity and mortality. Read More

    Impact of cardiac resynchronization therapy on mitral valve apparatus geometry and clinical outcomes in patients with secondary mitral regurgitation.
    Echocardiography 2017 Sep 12. Epub 2017 Sep 12.
    Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Background: Cardiac resynchronization therapy (CRT) may improve secondary mitral regurgitation (MR) in patients with cardiomyopathy. The effects on mitral valve (MV) and left ventricular (LV) geometry, however, have not been clearly defined.

    Methods: Between 2009 and 2012, 229 CRT implants were performed at a single academic center. Read More

    Valvular Heart Disease in Women, Differential Remodeling, and Response to New Therapies.
    Curr Treat Options Cardiovasc Med 2017 Sep 11;19(9):74. Epub 2017 Sep 11.
    The Zena and Michael A. Wiener Cardiovascular Institute, The Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1030, New York, NY, 10029-6574, USA.
    Opinion Statement: In the United States, valvular heart disease (VHD) has a prevalence of 2.5%, most commonly presenting as aortic stenosis (AS) or mitral valve regurgitation (MR) and increasingly observed to be of a degenerative etiology. Women frequently have latent symptoms despite significant disease, and it is therefore pertinent to consider both clinical symptoms and imaging findings for decision-making on treatment. Read More

    Severe Mitral Regurgitation in a Child With Henoch-Schönlein Purpura and Pulmonary Hemorrhage.
    Glob Pediatr Health 2017 1;4:2333794X17726940. Epub 2017 Sep 1.
    Oakland University William Beaumont School of Medicine, Rochester, MI, USA.
    Introduction: Henoch-Schönlein purpura (HSP) is the most common vasculitis of childhood. The classic triad of HSP consists of nonthrombocytopenic purpura, arthritis/arthralgia, and gastrointestinal complaints. Pulmonary hemorrhage and cardiac involvement are rare complications of HSP. Read More

    [Emergency Mitral Valvoplasty for Papillary Muscle Rupture].
    Kyobu Geka 2017 Sep;70(10):832-835
    Department of Emergency, Asahikawa Red Cross Hospital, Asahikawa, Japan.
    We experienced 2 emergency surgical cases of severe mitral valve regurgitation due to papillary muscle rupture. Case 1:a 69-year-old man presented with respiratory and cardiac failure due to mitral regurgitation. He had no history of myocardial infarction. Read More

    Early results of robotically assisted mitral valve surgery: Analysis of the first 1000 cases.
    J Thorac Cardiovasc Surg 2017 Aug 1. Epub 2017 Aug 1.
    Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
    Objective: The study objective was to assess the technical and process improvement and clinical outcomes of robotic mitral valve surgery by examining the first 1000 cases performed in a tertiary care center.

    Methods: We reviewed the first 1000 patients (mean age, 56 ± 10 years) undergoing robotic primary mitral valve surgery, including concomitant procedures (n = 185), from January 2006 to November 2013. Mitral valve disease cause was degenerative (n = 960, 96%), endocarditis (n = 26, 2. Read More

    Calcium on Mitral Valve: Decipher Aetiopathogenesis.
    J Clin Diagn Res 2017 Jul 1;11(7):OD03-OD04. Epub 2017 Jul 1.
    Head and Professor, Department of Cardiology, Govt. Medical College and Super Speciality Hospital, Nagpur, Maharashtra, India.
    We hereby describe an unusual case of a 17-year-old female with severe mitral regurgitation secondary to heavily calcified immobile valve leaflets. Along with the mitral valve, corneas were also calcified, due to congenital systemic metabolic disorder, distal renal tubular acidosis. Histopathology proved that there was no intrinsic pathology of the mitral valve. Read More

    A focussed single-view hand-held echocardiography protocol for the detection of rheumatic heart disease.
    Cardiol Young 2017 Sep 11:1-10. Epub 2017 Sep 11.
    2Children's National Health System,Washington,District of Columbia,United States of America.
    Background: Echocardiographic screening represents an opportunity for reduction in the global burden of rheumatic heart disease. A focussed single-view screening protocol could allow for the rapid training of healthcare providers and screening of patients.

    Objective: The aim of this study was to determine the sensitivity and specificity of a focussed single-view hand-held echocardiographic protocol for the diagnosis of rheumatic heart disease in children. Read More


    Left ventricular blood cyst in an adult case.
    Clin Case Rep 2017 Sep 20;5(9):1441-1443. Epub 2017 Jul 20.
    Division of Cardiovascular SurgeryDepartment of SurgeryJichi Medical UniversityShimotsukeJapan.
    We present a 57-year-old man with a 1.5-cm-diameter blood cyst in the left ventricle, which was incidentally detected by conventional diagnostic echocardiography before colon surgery. The cyst originated from the papillary muscle, and the pathological findings were compatible with a cardiac blood cyst. Read More

    Transcatheter Mitral Valve Replacement with the Edwards Sapien 3 Valve.
    Tex Heart Inst J 2017 Aug 1;44(4):269-273. Epub 2017 Aug 1.
    We describe the case of a 57-year-old man who had severe mitral valve stenosis and regurgitation without significant annular calcification. He was not a candidate for surgical valve replacement or repair because of his substantial comorbid conditions, overall frailty, and elevated surgical risk. He underwent successful transcatheter mitral valve replacement of his native mitral valve with compassionate, off-label use of an Edwards Sapien 3 valve. Read More

    Survival and Cardiovascular Outcomes of Patients With Secondary Mitral Regurgitation: A Systematic Review and Meta-analysis.
    JAMA Cardiol 2017 Sep 6. Epub 2017 Sep 6.
    Division of Cardiology, Department of Medicine, Baylor University Medical Center, Baylor Heart and Vascular Hospital, Dallas, Texas.
    Importance: The outcomes of patients with left ventricular (LV) dysfunction and secondary mitral regurgitation (SMR) are still controversial.

    Objective: To clarify the role of SMR in the outcomes of patients with ischemic or idiopathic cardiomyopathies.

    Data Sources: MEDLINE, ISI Web of Science, and Scopus databases were searched for studies published up to March 2017. Read More

    MANAGEMENT OF FAILED MITRAL VALVE REPLACEMENT. THE DURBAN EXPERIENCE.
    S Afr J Surg 2017 Jun;55(2):72
    Surgery, University of KwaZulu-Natal, Durban.
    Background: Mitral valve replacement is the procedure of choice in patients with severe mitral valve disease. However, these patients are surviving longer and are thus at an increased risk of prosthesis failure or valve-related complications.

    Method: Study setting: Inkosi Albert Luthuli Central Hospital, a tertiary referral Hospital in Durban. Read More

    Multimodality imaging in the diagnosis of a large accessory papillary muscle.
    R I Med J (2013) 2017 Sep 1;100(9):33-36. Epub 2017 Sep 1.
    Department of Internal Medicine, Memorial Hospital of Rhode Island, Warren Alpert Medical School of Brown University; Department of Cardiology, Brigham and Woman's Hospital, Boston, Massachusetts.
    An accessory papillary muscle is an uncommon congenital anomaly usually found incidentally on routine cardiac imaging. While frequently asymptomatic, it is occasionally associated with mitral regurgitation, left ventricular dynamic outflow obstruction and hypertrophic cardiomyopathy1 and it is important to differentiate it from other pathological processes including papillary fibroelastoma, left ventricle thrombus, hemangioma, a single papillary muscle with a parachute mitral valve and a left ventricle false tendon. The clinical implication of these findings varies according to the degree of left ventricular out flow obstruction, location and pathology. Read More

    Ischaemia as a cause of LVOT gradient reversal in HOCM.
    Echo Res Pract 2017 Sep 4. Epub 2017 Sep 4.
    Demetrescu C, Echocardiography, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
    We present the case of a sprightly 84 year old female with hypertrophic obstructive cardiomyopathy (HOCM) echo phenotype with asymmetrical septal hypertrophy, significant left ventricular (LV) outflow obstruction (LVOT) and mitral regurgitation (MR) at rest. Valsalva provocation caused an increase in LVOT dynamic gradient and MR severity. The patient presented with progressive decrease in exercise capacity and chest pain relieved by rest or sublingual GTN spray. Read More

    Current status of MitraClip for patients with mitral and tricuspid regurgitation.
    Trends Cardiovasc Med 2017 Aug 18. Epub 2017 Aug 18.
    Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. Electronic address:
    Mitral valve regurgitation (MR) affects approximately 4 million people in the United States alone, increasing in prevalence with age. Approved by the Food and Drug Administration (FDA) in October 2013, percutaneous edge-to-edge transcatheter mitral valve repair (also known as the MitraClip system) has been used in over 40,000 patients globally. Additionally, there is keen interest and early exploration into the use of MitraClip for treatment of severe symptomatic tricuspid regurgitation, another undertreated disease with significant morbidity and mortality. Read More

    Serotonin and catecholamines in the development and progression of heart valve diseases.
    Cardiovasc Res 2017 Jul;113(8):849-857
    Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
    Heart valve diseases (HVDs) arise from a number of different processes that affect both the structure and function of the valve apparatus. Despite diverse aetiologies, treatments for HVDs are limited to percutaneous or surgical interventions. The search for medical therapies to prevent or slow the progression of HVDs has been hampered by our poor understanding of the progression from subclinical to symptomatic phases, and our limited knowledge of the molecular signals that control the susceptibility of valve interstitial cells to pathological remodeling. Read More

    Periorbital ecchymoses and breathlessness.
    J Fam Pract 2017 Sep;66(9):E11-E13
    Department of Biochemistry, College of Medicine and Sagore Dutta Hospital, West Bengal, India.
    A 54-year-old man presented at our facility with a 3-month history of exertional breathlessness and purple blotches around his eyes. Examination revealed bilateral periorbital and perioral ecchymosis, purpuric spots along his waist, and waxy papules on his eyelids. In addition, the patient had macroglossia with nodular infiltration and irregular indentations at the lateral margin of his tongue. Read More

    A systematic review of reported cases of combined transcatheter aortic and mitral valve interventions.
    Catheter Cardiovasc Interv 2017 Sep 1. Epub 2017 Sep 1.
    Division of Cardiology, Wayne State University/Detroit Medical Center, Detroit, Michigan.
    Objectives: To summarize the published data of combined transcatheter aortic and mitral valve intervention (CTAMVI).

    Background: CTAMVI, a combination of either transcatheter aortic valve replacement (TAVR) or transcatheter aortic valve-in-valve (TAViV) and transcatheter mitral valve replacement (TMVR), transcatheter mitral valve-in-valve/valve-in-ring (TMViV/ViR), or percutaneous mitral valve repair (PMVR) is an attractive alternative in high-surgical risk patients with combined aortic and mitral valve disease. However, its procedural details and clinical outcomes have not been well described. Read More

    A Review of the Use of Cardiac Computed Tomography for Evaluating the Mitral Valve before and after Mitral Valve Repair.
    Korean J Radiol 2017 Sep-Oct;18(5):773-785. Epub 2017 Jul 17.
    Department of Thoracic and Cardiovascular Surgery, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University, Biomedical Research Institute of Chonbuk National University Hospital, Jeonju 54907, Korea.
    The role of cardiac computed tomography (CT) for evaluating the mitral valve (MV) has been limited since echocardiography is the main method of evaluation. However, recent advances in cardiac CT have enable detailed evaluation of the anatomy and geometry of the MV. We describe assessments of the anatomy and coaptation geometric parameters of normal MVs, and also review repair of diseased/damaged MV. Read More

    Features of cardiac remodeling in Patients with Acute Coronary Syndrome Complicated with Rheumatoid Arthritis.
    Sci Rep 2017 Aug 31;7(1):10268. Epub 2017 Aug 31.
    Department of Rheumatology and Immunology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
    Cardiovascular diseases are important factors to increased morbidity and mortality in patients with rheumatoid arthritis (RA). The aim of this study is to investigate the effects of RA on cardiac remodeling in patients with acute coronary syndrome (ACS). Sixty-one patients with ACS complicated with RA (RA group) and 55 age- and sex-matched patients with ACS without RA (control group) were enrolled. Read More

    Effect of Losartan on Mitral Valve Changes After Myocardial Infarction.
    J Am Coll Cardiol 2017 Sep;70(10):1232-1244
    Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Departments of Cardiology and Cardiovascular Surgery, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, University Paris Descartes, INSERM Unit 633, Paris, France. Electronic address:
    Background: After myocardial infarction (MI), mitral valve (MV) tethering stimulates adaptive leaflet growth, but counterproductive leaflet thickening and fibrosis augment mitral regurgitation (MR), doubling heart failure and mortality. MV fibrosis post-MI is associated with excessive endothelial-to-mesenchymal transition (EMT), driven by transforming growth factor (TGF)-β overexpression. In vitro, losartan-mediated TGF-β inhibition reduces EMT of MV endothelial cells. Read More

    Evolution of Functional Mitral Regurgitation and Prognosis in Medically Managed Heart Failure Patients With Reduced Ejection Fraction.
    JACC Heart Fail 2017 Sep;5(9):652-659
    Department of Cardiology, Antwerp University Hospital, Antwerp, Belgium. Electronic address:
    Objectives: The purpose of this study was to assess whether medical management may alter the severity of functional mitral regurgitation (FMR) and its prognosis in patients who have heart failure with reduced ejection fraction (HFrEF).

    Background: FMR in patients who have HFrEF is associated with a worse prognosis. It is uncertain to what extent medical management may alter the severity of FMR and its prognosis. Read More

    A rapid echocardiographic screening protocol for rheumatic heart disease in Samoa: a high prevalence of advanced disease.
    Cardiol Young 2017 Oct;27(8):1599-1605
    4Department of Biology,Brigham Young University,Provo,Utah,United States of America.
    Background: Echocardiography has been proposed as a method to screen children for rheumatic heart disease. The World Heart Federation has established guidelines for echocardiographic screening. In this study, we describe a rapid echocardiogram screening protocol according to the World Heart Federation guidelines in Samoa, endemic for rheumatic heart disease. Read More

    Sequential Venous Percutaneous Transluminal Angioplasty and Balloon Dilatation of the Interatrial Septum during Percutaneous Edge-to-Edge Mitral Valve Repair.
    Case Rep Cardiol 2017 9;2017:3652413. Epub 2017 Aug 9.
    University Hospital, Department of Cardiology and Cardiovascular Medicine, Eberhard Karls University Tuebingen, Tuebingen, Germany.
    Percutaneous edge-to-edge mitral valve repair (PMVR) is widely used for selected, high-risk patients with severe mitral valve regurgitation (MR). This report describes a case of 81-year-old woman presenting with severe and highly symptomatic mitral valve regurgitation (MR) caused by a flail of the posterior mitral valve leaflet (PML). PMVR turned out to be challenging in this patient because of a stenosis and tortuosity of both iliac veins as well as sclerosis of the interatrial septum, precluding the vascular and left atrial access by standard methods, respectively. Read More

    Relationship of cardiac troponin to systolic global longitudinal strain in hypertrophic cardiomyopathy.
    Echocardiography 2017 Aug 28. Epub 2017 Aug 28.
    Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Centers, University of Wisconsin School of Medicine and Public Health, Milwaukee, WI, USA.
    Background: A high proportion of stable hypertrophic cardiomyopathy (HCM) patients have elevated serum cardiac troponin I (cTnI), but its clinical and echocardiographic determinants are unknown. Our objective was to determine the prevalence and clinical predictors of positive troponin (cTnI+) in a well-defined population of HCM patients using a highly sensitive assay.

    Methods: We retrospectively interrogated medical records of 167 stable HCM patients from 1/2011 to 3/2014. Read More

    Timing of Surgery for Fungal Infective Endocarditis.
    Heart Surg Forum 2017 08 24;20(4):E129-E131. Epub 2017 Aug 24.
    Division of Cardiovascular surgery, Department of Surgery, Changhua Christian Hospital, Taiwan, China.
    Fungal endocarditis rarely occurs and is difficult to treat. Taguchi et al described that a 55-year-old man, who developed severe mitral regurgitation with persistent fungal infective endocarditis (IE) 8 months after coronary artery bypass grafting, was cured with mitral valve replacement via the anterolateral right thoracotomy without cross-clamping method [Taguchi 2016]. Read More

    Incidence, risk factors, and mortality of neonatal and late-onset dilated cardiomyopathy associated with cardiac neonatal lupus.
    Int J Cardiol 2017 Dec 7;248:263-269. Epub 2017 Aug 7.
    AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Paris, France. Electronic address:
    Background: Dilated cardiomyopathy (DCM), a well-known complication of cardiac neonatal lupus, is associated with high mortality rate. Its risk factors remain unclear.

    Methods: We analyzed occurrence of postnatal DCM among children with high-degree congenital heart block (CHB) and mothers with anti-SSA and/or anti-SSB antibodies. Read More

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