85,628 results match your criteria Missouri Medicine [Journal]


It's time to treat exercise in pregnancy as therapy.

Br J Sports Med 2018 Dec 15. Epub 2018 Dec 15.

Department of Obstetrics/Gynecology, St Louis University, St Louis, Missouri, USA.

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December 2018

New and Recurrent Colorectal Cancers After Resection: a Systematic Review and Meta-analysis of Endoscopic Surveillance Studies.

Gastroenterology 2018 Dec 13. Epub 2018 Dec 13.

Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Research and University Hospital, Rozzano (MI), Italy.

Background & Aims: Outcomes of endoscopic surveillance following surgery for colorectal cancer (CRC) vary with the incidence and timing of CRC detection, at anastomoses or non- anastomoses in the colorectum. We performed a systematic review and meta-analysis to evaluate the incidence of CRCs identified during surveillance colonoscopies of patients who have already undergone surgery for this cancer.

Methods: We searched PubMed, EMBASE, SCOPUS, and the Cochrane Central Register of Clinical Trials through January 1, 2018 to identify studies investigating rates of CRCs at anastomoses or other locations in the colorectum after curative surgery for primary CRC. Read More

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December 2018

Smc3 is required for mouse embryonic and adult hematopoiesis.

Exp Hematol 2018 Dec 13. Epub 2018 Dec 13.

Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri. Electronic address:

SMC3 encodes a subunit of the cohesin complex that has canonical roles in regulating sister chromatids segregation during mitosis and meiosis. Recurrent heterozygous mutations in SMC3 have been reported in acute myeloid leukemia (AML) and other myeloid malignancies. In this study, we investigated whether the missense mutations in SMC3 might have dominant-negative effects or phenocopy loss-of-function effects by comparing the consequences of Smc3 deficient and haploinsufficient mouse models. Read More

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December 2018

The "myth" of iodine allergy to radiocontrast in Emergency Medicine.

Am J Emerg Med 2018 Dec 8. Epub 2018 Dec 8.

University of Missouri-Columbia, Department of Emergency Medicine, United States of America.

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December 2018

A molecular approach combined with American Thyroid Association classification better stratifies recurrence risk of classic histology papillary thyroid cancer.

Cancer Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.

Background: Prognosis among patients with differentiated thyroid cancer is widely variable. Better understanding of biologic subtypes is necessary to stratify patients and improve outcomes.

Methods: In patients diagnosed with classic histology papillary thyroid cancer treated from 1973 to 2009, BRAF V600E mutation status was determined on surgical tumor specimens by restriction fragment length polymorphism analysis. Read More

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December 2018
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Genome-scale fluxome of Synechococcus elongatus UTEX 2973 using transient 13C-labeling data.

Plant Physiol 2018 Dec 14. Epub 2018 Dec 14.

The Pennsylvania State University CITY: University Park STATE: Pennsylvania POSTAL_CODE: n/a United States Of America [US]

Synechococcus elongatus UTEX 2973 (Synechococcus 2973) has the shortest reported doubling time (2.1 h) among cyanobacteria, making it a promising platform for the solar-based production of biochemicals. In this meta-analysis, its intracellular flux distribution was re-computed using genome-scale Isotopic Non-Stationary-13C-Metabolic Flux Analysis (INST-MFA) given the labeling dynamics of 13 metabolites reported in an earlier study. Read More

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December 2018

Phase II Randomized Trial of Sequential or Concurrent FOLFOXIRI-Bevacizumab Versus FOLFOX-Bevacizumab for Metastatic Colorectal Cancer (STEAM).

Oncologist 2018 Dec 14. Epub 2018 Dec 14.

Sarah Cannon Research Institute/Tennessee Oncology, Nashville, Tennessee, USA.

Background: First-line treatment for metastatic colorectal cancer (mCRC) typically entails a biologic such as bevacizumab (BEV) with 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX) or 5-fluorouracil/leucovorin/irinotecan (FOLFIRI). STEAM (NCT01765582) assessed the efficacy of BEV plus FOLFOX/FOLFIRI (FOLFOXIRI), administered concurrently (cFOLFOXIRI-BEV) or sequentially (sFOLFOXIRI-BEV, FOLFOX-BEV alternating with FOLFIRI-BEV), versus FOLFOX-BEV for mCRC.

Patients And Methods: Patients with previously untreated mCRC ( = 280) were randomized 1:1:1 to cFOLFOXIRI-BEV, sFOLFOXIRI-BEV, or FOLFOX-BEV and treated with 4-6-month induction followed by maintenance. Read More

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December 2018

Posteromedial rotatory incongruity of the elbow: a computational kinematics study.

J Shoulder Elbow Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Orthopaedic Surgery, University of Missouri-Kansas City, Kansas City, MO, USA.

Background: Our objective was to analyze the effect of different anteromedial coronoid fracture patterns with different combinations of ligamentous repairs. We hypothesized that smaller fractures would be sufficiently treated with ligamentous repair alone but that larger fragments would require a combination of ligament and bony repair versus reconstruction.

Methods: Two multibody models were created from cadaveric specimens in the ADAMS program. Read More

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December 2018

Precision Medicine in Pediatric Cancer: Current Applications and Future Prospects.

High Throughput 2018 Dec 13;7(4). Epub 2018 Dec 13.

Departments of Pathology and Pediatric Hematology-Oncology, University of Missouri School of Medicine, Kansas City, MO 64108, USA.

Precision oncologic medicine is an emerging approach for cancer treatment that has recently taken giant steps in solid clinical practice. Recent advances in molecular diagnostics that can analyze the individual tumor's variability in genes have provided greater understanding and additional strategies to treat cancers. Although tumors can be tested by several molecular methods, the use of next-generation sequencing (NGS) has greatly facilitated our understanding of pediatric cancer and identified additional therapeutic opportunities. Read More

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December 2018

Comparative Analysis of the Exposure and Surgical Freedom of the Endoscopic Extended Minipterional Craniotomy and the Transorbital Endoscopic Approach to the Anterior and Middle Cranial Fossae.

Oper Neurosurg (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurosurgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: Numerous minimally invasive approaches to the skull base have been successively developed. Knowledge of the surgical nuances of a specific approach may facilitate approach selection. This study sought to compare the nuances of an extended version of the minipterional craniotomy (EMPT) with those of the transorbital endoscopic approach (TOEA) to the anterior and middle cranial fossae (ACF and MCF, respectively). Read More

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December 2018
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A plastid phylogeny of the fern genus Arachniodes (Dryopteridaceae).

Mol Phylogenet Evol 2018 Dec 11. Epub 2018 Dec 11.

CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, P.O. Box 416, Chengdu, Sichuan 610041, China; Missouri Botanical Garden,4344 Shaw Blvd., St. Louis, Missouri 63110, U.S.A. Electronic address:

Arachniodes (Dryopteridaceae) is one of the most confusing and controversial fern genera in terms of its circumscription, nomenclature, and taxonomy. Estimates of species number range from 40 to 200. Previous molecular works included only 2-17 accessions representing 2-12 species of Arachniodes and allied genera, leaving most of the Asian species remain unsampled and the infragneric relationships unclear. Read More

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December 2018
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A Survey of Mohs Tissue Tracking Practices.

Dermatol Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology, MD Anderson Cancer Center, Houston, Texas.

Background: There are little data regarding error within the multistep process of Mohs micrographic surgery (MMS).

Objective: A survey of Mohs surgeons was performed to evaluate variation in tissue handling and processing within the MMS process.

Methods And Materials: A 9-question electronic survey was distributed to members of the American College of Mohs Micrographic Surgery. Read More

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December 2018
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Discrepancy Between Online Images of Mohs Surgery and Reality: An Opportunity for Improvement.

Dermatol Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology, University of Minnesota, Minneapolis, Minnesota Department of Dermatology, Saint Louis University, St. Louis, Missouri.

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December 2018

Does Hands-on Guarding Influence Performance on the Functional Gait Assessment?

J Geriatr Phys Ther 2018 Dec 12. Epub 2018 Dec 12.

CoxHealth, Springfield, Missouri.

Background And Purpose: An accurate fall risk assessment is an important component of fall prevention, though a fall could occur during testing. To minimize this risk, different guarding methods are used, though there is disagreement regarding the optimal method. The purpose of this study was to compare the effect of 2 guarding methods, contact guarding (CG) and standby guarding (SG), on performance during the Functional Gait Assessment (FGA). Read More

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December 2018

Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review.

Anesthesiology 2019 Jan;130(1):41-54

From The North American Malignant Hyperthermia Registry of the Malignant Hyperthermia Association of the United States, University of Pittsburgh Medical Center, Mercy Hospital, Pittsburgh, Pennsylvania (2000 through 2017; M.G.L., B.W.B.) Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida (2018; M.G.L.) Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan (T.T.K., M.T.V., S.K.) Department of Nurse Anesthesia, University of Pittsburgh, Pittsburgh, Pennsylvania (2016 through 2018; B.W.B.) Department of Anesthesiology, School of Medicine (K.G.B., T.W.K., J.C.) School of Public Health (K.G.B.), University of Minnesota, Minneapolis, Minnesota Department of Anesthesiology, Children's Hospital of Pittsburgh (E.L.S.) Department of Anesthesiology (A.H.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania Department of Anesthesiology, Weill Cornell Medical College and New York-Presbyterian Hospital, New York, New York (J.L.) Department of Anesthesia and Pain Management, University Health Network, University of Toronto, Toronto, Canada (S.R.) Department of Anesthesiology and Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Egleston Hospital, Atlanta, Georgia (D.M.). Current positions: Dr. Larach is now at the Department of Anesthesiology, University of Florida, Gainesville, Florida. Dr. Sivak is now at the Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio. Department of Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands Beaumont Health, Dearborn, Michigan Beaumont Health, Royal Oak, Michigan Beaumont Health, Farmington Hills, Michigan Beaumont Health, Grosse Pointe, Michigan Bronson Healthcare, Battle Creek, Michigan Bronson Healthcare, Kalamazoo, Michigan CHOC Children's Hospital, Orange, California Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio Department of Anesthesiology, Columbia University Medical Center, New York, New York Henry Ford Health System, Detroit, Michigan Henry Ford Health System, West Bloomfield, Michigan Holland Hospital, Holland, Michigan Mercy Health, Muskegon, Michigan Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Department of Anesthesiology, Perioperative Care, and Pain Medicine, New York University Langone Medical Center, New York, New York Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, Oregon St. Joseph Mercy, Ann Arbor, Michigan St. Joseph Mercy Oakland, Pontiac, Michigan St. Mary Mercy Hospital, Livonia, Michigan Sparrow Health System, Lansing, Michigan Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California Department of Anesthesiology, University Medical Center Utrecht, Utrecht, The Netherlands Department of Anesthesiology, University of Colorado, Aurora, Colorado Department of Anesthesiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma Department of Anesthesiology, University of Pennsylvania, Philadelphia, Pennsylvania Department of Anesthesiology, University of Tennessee Medical Center, Knoxville, Tennessee Department of Anesthesiology, University of Utah, Salt Lake City, Utah Department of Anesthesiology, University of Vermont, Larner College of Medicine, Burlington, Vermont Department of Anesthesiology, University of Virginia, Charlottesville, Virginia Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee Department of Anesthesiology, Wake Forest Baptist Health, Winston-Salem, North Carolina Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri Department of Anesthesiology, Weill Cornell Medical College, New York, New York Department of Anesthesiology, Yale School of Medicine, New Haven, Connecticut.

What We Already Know About This Topic: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Although dantrolene effectively treats malignant hyperthermia (MH), discrepant recommendations exist concerning dantrolene availability. Whereas Malignant Hyperthermia Association of the United States guidelines state dantrolene must be available within 10 min of the decision to treat MH wherever volatile anesthetics or succinylcholine are administered, a Society for Ambulatory Anesthesia protocol permits Class B ambulatory facilities to stock succinylcholine for airway rescue without dantrolene. The authors investigated (1) succinylcholine use rates, including for airway rescue, in anesthetizing/sedating locations; (2) whether succinylcholine without volatile anesthetics triggers MH warranting dantrolene; and (3) the relationship between dantrolene administration and MH morbidity/mortality. Read More

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January 2019

Impact of genetic variation on pravastatin systemic exposure in pediatric hypercholesterolemia.

Clin Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.

Division of Clinical Pharmacology, Medical Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, MO.

This study investigated the impact of SLCO1B1 genotype on pravastatin systemic exposure in hypercholesterolemic children and adolescents. Participants (8-20 years) with at least one allelic variant of SLCO1B1 c.521T>C (521TC, n=15; 521CC, n=2) and wild type controls (521TT, n=15) completed a single oral dose pharmacokinetic study. Read More

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December 2018

Cognitive performance in patients with implantable cardioverter defibrillators: Associations with objective sleep duration, age and anxiety.

J Sleep Res 2018 Dec 13:e12810. Epub 2018 Dec 13.

Department of Psychiatry, University of Missouri, Columbia, Missouri.

Sleep disturbance and anxiety are highly prevalent in patients with implantable cardiac defibrillators (ICDs). There is limited research, however, on the associations between cognitive performance and sleep parameters, age and anxiety. Forty-one patients with ICDs and self-reported sleep disturbance completed 14 days of actigraphy (M  = 60. Read More

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December 2018

Endotracheal intubation results in acute tracheal damage induced by mtDNA/TLR9/NF-κB activity.

J Leukoc Biol 2018 Dec 13. Epub 2018 Dec 13.

Surgery, Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.

Tracheitis secondary to placement of an endotracheal tube (ETT) is characterized by neutrophil accumulation in the tracheal lumen, which is generally associated with epithelial damage. Mitochondrial DNA (mtDNA), has been implicated in systemic inflammation and organ dysfunction following trauma; however, less is known about the effects of a foreign body on local trauma and tissue damage. We hypothesized that tracheal damage secondary to the ETT will result in local release of mtDNA at sufficient levels to induce TLR9 and NF-κB activation. Read More

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December 2018

Mineralized microbialites as archives of environmental evolution, Laguna Negra, Catamarca Province, Argentina.

Geobiology 2018 Dec 13. Epub 2018 Dec 13.

Department of Earth & Planetary Sciences, The University of Tennessee, Knoxville, Tennessee.

Environmental fluctuations are recorded in a variety of sedimentary archives of lacustrine depositional systems. Geochemical signals recovered from bottom sediments in closed-basin lakes are among the most sensitive paleoenvironmental indicators and are commonly used in reconstructing lake evolution. Microbialites (i. Read More

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December 2018

Behavioral and endocrine correlates of dominance in captive female Jackson's hartebeest (Alcelaphus buselaphus).

Zoo Biol 2018 Dec 13. Epub 2018 Dec 13.

Department of Biology, Georgia Southern University, Statesboro, Georgia.

For species that form dominance hierarchies, such as group-living ungulates, aggressive interactions can pose a challenge to successful captive management. For example, Jackson's hartebeest (Alcelaphus buselaphus), a rare antelope of east Africa, can be difficult to maintain in captivity because aggression within female dominance hierarchies can lead to injury and death. We quantified behavioral and endocrine correlates of dominance in a captive herd of ten female hartebeest with the goal of understanding how to minimize dangerous interactions. Read More

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December 2018

Trends in Female Leadership at High-Profile Otolaryngology Journals, 1997-2017.

Laryngoscope 2018 Dec 13. Epub 2018 Dec 13.

Department of Otolaryngology-Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington.

Objectives: To determine the proportion and relative advancement of women in leadership positions at high-impact otolaryngology journals.

Methods: Nine clinical otolaryngology journals were selected based on high impact factor and subspecialty representation (journal impact factor, 2016: 1.16-2. Read More

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December 2018
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Geriatric Assessment in Older Adults with Multiple Myeloma.

J Am Geriatr Soc 2018 Dec 13. Epub 2018 Dec 13.

Division of Public Health Sciences, Washington University School of Medicine, St Louis, Missouri.

Background/objectives: The incidence of myeloma in older adults is increasing, yet little is known about geriatric impairments in these patients. We aimed to examine the prevalence of geriatric impairments in older adults with myeloma and the association between geriatric assessment and autologous stem cell transplant eligibility.

Design: Prospective cohort study. Read More

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December 2018

Application of a recursive partitioning decision tree algorithm for the prediction of massive transfusion in civilian trauma: the MTPitt prediction tool.

Transfusion 2018 Dec 12. Epub 2018 Dec 12.

Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Background: A supervised machine learning algorithm was used to generate decision trees for the prediction of massive transfusion at a Level 1 trauma center.

Methods: Trauma patients who received at least one unit of RBCs and/or low-titer group O whole blood between January 1, 2015, and December 31, 2017, were included. Massive transfusion was defined as the transfusion of 10 or more units of RBCs and/or low-titer group O whole blood in the first 24 hours of admission. Read More

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December 2018
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Doubled lifespan and patient-like pathologies in progeria mice fed high-fat diet.

Aging Cell 2018 Dec 12:e12852. Epub 2018 Dec 12.

Edward A. Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri.

Hutchinson-Gilford Progeria Syndrome (HGPS) is a devastating premature aging disease. Mouse models have been instrumental for understanding HGPS mechanisms and for testing therapies, which to date have had only marginal benefits in mice and patients. Barriers to developing effective therapies include the unknown etiology of progeria mice early death, seemingly unrelated to the reported atherosclerosis contributing to HGPS patient mortality, and mice not recapitulating the severity of human disease. Read More

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December 2018
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TREM2 triggers microglial density and age-related neuronal loss.

Glia 2018 Dec 11. Epub 2018 Dec 11.

Neural Regeneration, Institute of Reconstructive Neurobiology, University Hospital of Bonn, University of Bonn, Bonn, Germany.

The microglial triggering receptor expressed on myeloid cells 2 (TREM2) signals via the activatory membrane adaptor molecule TYROBP. Genetic variants or mutations of TREM2 or TYROBP have been linked to inflammatory neurodegenerative diseases associated with aging. The typical aging process goes along with microglial changes and mild neuronal loss, but the exact contribution of TREM2 is still unclear. Read More

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December 2018

The use of whole blood in US military operations in Iraq, Syria, and Afghanistan since the introduction of low-titer Type O whole blood: feasibility, acceptability, challenges.

Transfusion 2018 Dec 11. Epub 2018 Dec 11.

Armed Service Blood Program, Brooke Army Medical Center, JBSA-Fort Sam Houston, Texas.

Background: Hemorrhage is the leading cause of preventable death in military and civilian traumatic injury. Blood product resuscitation improves survival. Low-titer Type O Whole Blood (LTOWB) was recently re-introduced to the combat theater as a universal resuscitation product for hemorrhagic shock. Read More

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December 2018
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Fractional Angular Momentum at Topological Insulator Interfaces.

Phys Rev Lett 2018 Nov;121(22):227001

Institute for Theoretical Solid State Physics, IFW Dresden, Helmholtzstrasse 20, 01069 Dresden, Germany.

Recently, two fundamental topological properties of a magnetic vortex at the interface of a superconductor (SC) and a strong topological insulator (TI) have been established: The vortex carries both a Majorana zero mode relevant for topological quantum computation and, for a time-reversal invariant TI, a charge of e/4. This fractional charge is caused by the axion term in the electromagnetic Lagrangian of the TI. Here we determine the angular momentum J of the vortices, which in turn determines their mutual statistics. Read More

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November 2018

Risk Factors for Short- and Long-Term Outcomes in Children With STEC-HUS/D HUS: A Single-Center Experience.

Glob Pediatr Health 2018 4;5:2333794X18816920. Epub 2018 Dec 4.

The Children's Mercy Hospitals and Clinics, Kansas City, MO, USA.

. Hemolytic uremic syndrome (HUS) is one of the common causes for acute kidney injury in childhood. . Read More

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December 2018

Kazin's Trilling: A Cold War Portrait.

Authors:
Richard M Cook

Society 2018 5;55(6):506-511. Epub 2018 Nov 5.

College of Arts and Sciences, Department of English, University of Missouri-St. Louis, 461 Lucas Hall, 1 University Blvd, St. Louis, MO 63121-4400 USA.

This essay describes the eminent Americanist, critic, and New York intellectual, Alfred Kazin's creation of a Lionel Trilling "character" in his 1978 autobiography, , and his use of that character to critique significant features of the country's Cold War literary culture. Among these are: the narrowing and hardening of intellectual discourse in a cultural-political climate dominated by the "liberal consensus," the discrediting of the progressive impulse in American writing, the subordination of "class" to "culture" in evaluations of American writers, and the changing status of Jews and Jewish writers in post-war America. Tapping into strong personal feelings, Kazin creates in Trilling a harsh, thoughtful and compelling portrait of an era. Read More

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November 2018

Effect of alcohol ingestion on plasma glucose kinetics after Roux-en-Y gastric bypass surgery.

Surg Obes Relat Dis 2018 Nov 2. Epub 2018 Nov 2.

Department of Food Science and Human Nutrition, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana-Champaign, Illinois; Division of Nutritional Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana-Champaign, Illinois. Electronic address:

Background: Roux-en-Y gastric bypass surgery (RYGB) increases the rate of alcohol absorption so that peak blood alcohol concentration is 2-fold higher after surgery compared with concentrations reached after consuming the same amount presurgery. Because high doses of alcohol can lead to hypoglycemia, patients may be at increased risk of developing hypoglycemia after alcohol ingestion.

Objectives: We conducted 2 studies to test the hypothesis that the consumption of approximately 2 standard drinks of alcohol would decrease glycemia more after RYGB than before surgery. Read More

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November 2018
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Integrating the PILP-mineralization process into a restorative dental treatment.

Dent Mater 2018 Dec 10. Epub 2018 Dec 10.

Department of Preventative and Restorative Dental Sciences, UCSF School of Dentistry, San Francisco, CA, USA. Electronic address:

The addition of charged polymers, like poly-aspartic acid (pAsp), to mineralizing solutions allows for transport of calcium and phosphate ions into the lumen of collagen fibrils and subsequent crystallization of oriented apatite crystals by the so-called Polymer-Induced Liquid Precursor (PILP) mineralization process, leading to the functional recovery of artificial dentin lesions by intrafibrillar mineralization of collagen.

Objective: To evaluate the feasibility of applying the PILP method as part of a restorative treatment and test for effectiveness to functionally remineralize artificial lesions in dentin.

Materials And Methods: Two methods of providing pAsp to standardized artificial lesions during a restorative procedure were applied: (A) pAsp was mixed into commercial RMGI (resin modified glass ionomer) cement formulations and (B) pAsp was added at high concentration (25mg/ml) in solution to rehydrate lesions before restoring with a RMGI cement. Read More

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December 2018
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Randomized sham-controlled trial of the 6-month swallowable gas-filled intragastric balloon system for weight loss.

Surg Obes Relat Dis 2018 Dec 29;14(12):1876-1889. Epub 2018 Sep 29.

Stony Brook Medicine, Stony Brook, New York.

Background: Obesity is a significant health problem and additional therapies are needed to improve obesity treatment.

Objective: Determine the efficacy and safety of a 6-month swallowable gas-filled intragastric balloon system for weight loss.

Setting: Fifteen academic and private practice centers in the United States. Read More

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December 2018

Proteomic Characterization of Bacteroids Reveals a Post-Symbiotic, Hemibiotrophic-Like Lifestyle of the Bacteria within Senescing Soybean Nodules.

Int J Mol Sci 2018 Dec 8;19(12). Epub 2018 Dec 8.

Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA.

The form and physiology of after the decline of symbiotic nitrogen fixation has been characterized. Proteomic analyses showed that post-symbiotic underwent metabolic remodeling as well-defined groups of proteins declined, increased or remained unchanged from 56 to 119 days after planting, suggesting a transition to a hemibiotrophic-like lifestyle. Enzymatic analysis showed distinct patterns in both the cytoplasm and the periplasm. Read More

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December 2018

Transcriptomic Characterization of Bacteroids Reveals a Post-Symbiotic, Hemibiotrophic-Like Lifestyle of the Bacteria within Senescing Soybean Nodules.

Int J Mol Sci 2018 Dec 7;19(12). Epub 2018 Dec 7.

Division of Biochemistry, University of Missouri, Columbia, MO 65211, USA.

The transcriptional activity of isolated from soybean nodules was monitored over the period from symbiosis to late plant nodule senescence. The bacteria retained a near constant level of RNA throughout this period, and the variation in genes demonstrating increased, decreased, and/or patterned transcriptional activity indicates that the bacteria are responding to the changing environment within the nodule as the plant cells progress from an organized cellular structure to an unorganized state of internal decay. The transcriptional variation and persistence of the bacteria suggest that the bacteria are adapting to their environment and acting similar to hemibiotrophs, which survive both as saprophytes on live plant tissues and then as necrophytes on decaying plant tissues. Read More

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December 2018

Dry eyes, dry mouth and kidney stones.

Rheumatology (Oxford) 2018 Dec 13. Epub 2018 Dec 13.

Rheumatology Division, Department of Medicine.

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December 2018
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Dynamics of aesthetic experience are reflected in the default-mode network.

Neuroimage 2018 Dec 10. Epub 2018 Dec 10.

Department of English, Pomona College, Claremont, CA, USA.

Neuroaesthetics is a rapidly developing interdisciplinary field of research that aims to understand the neural substrates of aesthetic experience: While understanding aesthetic experience has been an objective of philosophers for centuries, it has only more recently been embraced by neuroscientists. Recent work in neuroaesthetics has revealed that aesthetic experience with static visual art engages visual, reward and default-mode networks. Very little is known about the temporal dynamics of these networks during aesthetic appreciation. Read More

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December 2018

Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner.

PLoS Pathog 2018 Dec 13;14(12):e1007457. Epub 2018 Dec 13.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America.

Urinary tract infections (UTI) are extremely common and can be highly recurrent, with 1-2% of women suffering from six or more recurrent episodes per year. The high incidence of recurrent UTI, including recurrent infections caused by the same bacterial strain that caused the first infection, suggests that at least some women do not mount a protective adaptive immune response to UTI. Here we observed in a mouse model of cystitis (bladder infection) that infection with two different clinical uropathogenic Escherichia coli (UPEC) isolates, UTI89 or CFT073, resulted in different kinetics of bacterial clearance and different susceptibility to same-strain recurrent infection. Read More

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December 2018

Loncastuximab tesirine in patients with B-cell non-Hodgkin lymphoma.

Authors:
Brad S Kahl

Clin Adv Hematol Oncol 2018 Nov;16(11):732-734

Lymphoma Program, Washington University School of Medicine, St Louis, Missouri.

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November 2018

Synthesis and Characterization of Anionic Lanthanide(III) Complexes with a Bidentate Sulfonylamidophosphate (SAPh) Ligand.

Inorg Chem 2018 Dec 13. Epub 2018 Dec 13.

Department of Chemistry , Taras Shevchenko National University of Kyiv , 64/13 Volodymyrska Street , Kyiv 01601 , Ukraine.

A series of new anionic lanthanide(III) complexes with the general formula NEt[LnL] (1-Ln; HL = dimethyl[(4-methylphenyl)sulfonyl]amidophosphate; Ln = La, Nd, Eu), were synthesized and characterized by IR, UV-vis, and NMR spectroscopies, the differential scanning calorimetry method, thermogravimetric and X-ray analysis, and photoluminescence measurements. Single-crystal structures of NEt[EuL] (1-Eu) were determined at 293 and 100 K and evidenced the single-crystal-to-single-crystal phase transition. Both phases are in the monoclinic crystal system in centrosymmetric groups of the same Laue class. Read More

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December 2018

"Closing the Gap": Provider Recommendations for Implementing Birth Point of Care HIV Testing.

AIDS Behav 2018 Dec 12. Epub 2018 Dec 12.

Department of Family Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA.

Delays in traditional HIV DNA PCR testing for early infant diagnosis (EID) at 6 weeks of age result in late antiretroviral treatment (ART). Birth point of care (POC) testing is an emerging strategy with the potential to streamline EID services. We elicited providers' recommendations for introducing birth POC testing to guide strategies in Kenya and similar settings. Read More

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December 2018

Probucol protects circulating endothelial progenitor cells from ambient PM damage via inhibition of reactive oxygen species and inflammatory cytokine production .

Exp Ther Med 2018 Dec 24;16(6):4322-4328. Epub 2018 Sep 24.

Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.

Bone marrow-derived circulating endothelial progenitor cells (EPCs) contribute to angiogenesis and vascular repair. The number and function of EPCs are significantly decreased following exposure to ambient fine particulate matter of ≤2.5 µm in diameter (PM) through reactive oxygen species (ROS) generation and inflammatory cytokine secretion. Read More

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December 2018

Complex Structural Variant Associated with Non-syndromic Canine Retinal Degeneration.

G3 (Bethesda) 2018 Dec 12. Epub 2018 Dec 12.

University of Pennsylvania.

Rod and cone photoreceptors are specialized retinal neurons that have a fundamental role in visual perception, capturing light and transducing it into a neuronal signal. Aberrant functioning of rod and/or cone photoreceptors can ultimately lead to progressive degeneration and eventually blindness. In man, many rod and rod-cone degenerative diseases are classified as forms of retinitis pigmentosa (RP). Read More

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December 2018
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Acclimation and endogenous abscisic acid in the moss Physcomitrella patens during acquisition of desiccation tolerance.

Physiol Plant 2018 Dec 7. Epub 2018 Dec 7.

Department of Biology, University of South Dakota, Vermillion, SD, 57069, USA.

The moss Physcomitrella patens has been used as a model organism to study the induction of desiccation tolerance (DT), but links between dehydration rate, the accumulation of endogenous abscisic acid (ABA), and DT remain unclear. In this study, we show that prolonged acclimation of P. patens at 89% relative humidity (RH) (-16 MPa) can induce tolerance of desiccation at 33% RH (-153 MPa) in both protonema and gametophore stages. Read More

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December 2018

Micro-channel sieve electrode for concurrent bidirectional peripheral nerve interface. Part B: Stimulation.

J Neural Eng 2018 Nov 9. Epub 2018 Nov 9.

Department of Biomedical Engineering, Washington University in St Louis, Campus Box 1097, One Brookings Drive, Saint Louis, Missouri, 63130-4899, UNITED STATES.

Objective: Successful use of a prosthetic limb by an amputee is facilitated by haptic feedback - both a sense of touch and proprioception. Stimulating afferent fibers within peripheral nerves has been shown to provide somatosensation enabling amputees to modulate the control of prosthetic limbs. Peripheral nerve interfaces (PNIs) have also been used to decode patients' motor intentions. Read More

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November 2018

Micro-channel sieve electrode for concurrent bidirectional peripheral nerve interface. Part A: Recording.

J Neural Eng 2018 Nov 9. Epub 2018 Nov 9.

Department of Biomedical Engineering, Washington University in St Louis, Campus Box 1097, One Brookings Drive, Saint Louis, Missouri, 63130-4899, UNITED STATES.

Objective: Advancement in prosthetic limb technology requires corresponding improvements in the capability of the amputee to naturally control the device via original motor pathways while simultaneously receiving haptic feedback via sensory pathways. Recording efferent axonal activity using a peripheral neural interface (PNI) allows a good tradeoff between invasiveness and selectivity while possibly preserving the phenomenology of controlling the original limb. One such PNI, the thin-film transverse intrafascicular multichannel electrode (tfTIME), has been shown to be successful in controlling powered prosthetics. Read More

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November 2018

A short guide to working remotely.

Science 2018 Dec;362(6419):1206

Paul N. Frater is a Ph.D. candidate at the University of Iceland, working in Stevens Point, Wisconsin. Lauren L. Sullivan is a postdoctoral researcher at the University of Minnesota, working in St. Louis, Missouri. Send your career story to

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December 2018

Using Hyperpolarized Xenon-129 MRI to Quantify Early-Stage Lung Disease in Smokers.

Acad Radiol 2018 Dec 3. Epub 2018 Dec 3.

Center for In-vivo Hyperpolarized Gas MR Imaging, Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia.

Rationale And Objectives: Hyperpolarized xenon-129 magnetic resonance (MR) provides sensitive tools that may detect early stages of lung disease in smokers before it has progressed to chronic obstructive pulmonary disease (COPD) apparent to conventional spirometric measures. We hypothesized that the functional alveolar wall thickness as assessed by hyperpolarized xenon-129 MR spectroscopy would be elevated in clinically healthy smokers before xenon MR diffusion measurements would indicate emphysematous tissue destruction.

Materials And Methods: Using hyperpolarized xenon-129 MR we measured the functional septal wall thickness and apparent diffusion coefficient of the gas phase in 16 subjects with smoking-related COPD, 9 clinically healthy current or former smokers, and 10 healthy never smokers. Read More

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December 2018

Physical and Psychosocial Impact of a University-Based, Volunteer Student-Led Running Program for Children With Autism Spectrum Disorder.

J Am Acad Child Adolesc Psychiatry 2018 Dec;57(12):974-977

Washington University in St. Louis, MO. Electronic address:

Children with autism spectrum disorder (ASD) are frequently excluded from group sports. This accentuates the social isolation inherent in their condition, perpetuates cycles of perceived incompetence in physical activity, and increases susceptibility to weight gain influenced by psychotropic medications. In a 2015 study of 376 children with ASD, 18. Read More

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December 2018

Maintaining operative efficiency while allowing sufficient time for residents to learn.

Am J Surg 2018 Nov 27. Epub 2018 Nov 27.

University of Missouri-Kansas City School of Medicine, 2411 Holmes St, Kansas City, MO, 64108, USA. Electronic address:

Background: Surgical residents desire independent operating experience but recognize that attendings have a responsibility to keep cases as short as possible.

Methods: We analyzed video and interviews of attending surgeons related to more than 400 moments in which the resident was the primary operator. We examined these moments for themes related to timing and pace. Read More

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November 2018

30-Day Readmissions After Endovascular Thrombectomy for Acute Ischemic Stroke.

JACC Cardiovasc Interv 2018 Dec;11(23):2414-2424

Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

Objectives: The authors sought to investigate the incidence, predictors, and causes of 30-day nonelective readmissions after endovascular thrombectomy (EVT).

Background: Randomized trials have demonstrated that EVT improves outcomes in patients with acute ischemic stroke.

Methods: The Nationwide Readmissions Database, years 2013 and 2014, was used to identify hospitalizations for a primary diagnosis of acute ischemic stroke during which patients underwent EVT, with or without intravenous thrombolysis. Read More

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December 2018