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Eur J Contracept Reprod Health Care 2019 Feb 12:1-6. Epub 2019 Feb 12.

b Women's Health Hospital, Faculty of Medicine , Assiut University , Assiut , Egypt.

Objective: The study aimed to compare the efficacy and safety of sublingual and vaginal misoprostol for termination of pregnancy in women with first trimester missed abortion.

Methods: A single-blind, parallel group, randomised clinical trial (ClinicalTrials.gov NCT02686840) was conducted in a university hospital between 1 February 2016 and 31 January 2017. Read More

Cureus 2018 Nov 8;10(11):e3562. Epub 2018 Nov 8.

Obstetrics & Gynecology, King Saud Hospital, Unizah, SAU.

Placenta accreta is abnormal placental attachment to the myometrium, and the incidence rate has risen with the increased use of Cesarean sections. First-trimester placenta accreta is a rare, potentially life-threatening condition due to the severe hemorrhage it may cause, necessitating a hysterectomy. We present a case of a 38-year-old woman with a history of two Cesarean section deliveries who developed severe bleeding during curetting due to undiagnosed placenta accreta. Read More

Eur J Contracept Reprod Health Care 2018 Dec 2;23(6):451-457. Epub 2019 Jan 2.

b Department of Women's and Children's Health, Division of Obstetrics and Gynaecology , Karolinska Institutet and Karolinska University Hospital , Stockholm , Sweden.

Objective: Medical termination of pregnancy (MToP, or medical abortion) is a highly effective method with a reported efficacy of 95-98%. However, different criteria are currently used to define success, and there are different recommendations for the treatment of what is considered a failure of MToP. This work was undertaken to develop a consensus around a set of well-defined MToP outcomes, as recommended by the Core Outcomes in Women's and Newborn Health initiative. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13573

Department of Gynecology, the Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang.

The incidence of fertile women with missed abortion dramatically increased in recent years, while very few serum indices have been identified for the diagnosis of missed abortion. The aim of this study was to identify related factors for missed abortion through a retrospective study of serum indices.A total of 795 cases of women with missed abortion and 694 cases of women with normal pregnancy between March 2014 and March 2017 were included in the present study. Read More

Lancet Glob Health 2019 Jan 29;7(1):e12-e13. Epub 2018 Nov 29.

Aga Khan University, 00100 Nairobi, Kenya and Ghent University, Ghent, Belgium. Electronic address:

Neuro Endocrinol Lett 2018 Sep;39(3):156-159

Department of Pathology, Hospital Ceske Budejovice , Czech Republic.

Ectopic pregnancy is a condition when fertilized egg implants outside the uterine cavity. The reported incidence is about 0.5-1% of all pregnancies. Read More

J Gynecol Obstet Hum Reprod 2018 Oct 30. Epub 2018 Oct 30.

Department of Obstetrics and Gynaecology, Bangalore Baptist Hospital, Bangalore, Karnataka, India. Electronic address:

Objective: To determine the value of yolk sac size and shape for prediction of pregnancy outcome in the first trimester.

Material And Methods: 500 pregnant women between 6 and 9 weeks of gestation underwent transvaginal ultrasound and yolk sac diameter (YSD), gestational sac diameter (GSD) were measured, presence/absence of yolk sac (YS) and shape of the yolk sac were noted. Follow up ultrasound was done to confirm fetal well-being between 11 and 12 weeks and was the cutoff point of success of pregnancy. Read More

Hastings Cent Rep 2018 Sep;48(5):3-4

If you blinked you may have missed it. The Department of Health and Human Services published its strategic plan for the 2018-2022 fiscal years, which includes the statement that HHS accomplishes its mission through programs and initiatives that serve and protect "Americans at every stage of life, from conception." Of note, the "from conception" language is new and, depending on the direction President Trump's administration plans to go, could have profound implications for the regulation of reproductive services ranging from abortion to in vitro fertilization (IVF). Read More

Gynecol Minim Invasive Ther 2017 Oct-Dec;6(4):183-185. Epub 2017 Jun 13.

Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Affiliated with Tel-Aviv University, Sackler School of Medicine, Israel.

Study Objective: To investigate the use of operative hysteroscopy instead of traditional curettage in women with retained products of conception (RPOC) following first trimester medical abortion, with the aim of reducing post-operative intrauterine adhesions.

Design: Retrospective study.

Setting: Gynecology department in a University affiliated hospital. Read More

BMC Pregnancy Childbirth 2018 Sep 5;18(1):360. Epub 2018 Sep 5.

Department of Obstetrics and Gynecology, KK Women's and Children's Hospital, Singapore, 100 Bukit Timah Road, Singapore, 229899, Singapore.

Background: Progesterone is a critical hormone in early pregnancy. A low level of serum progesterone is associated with threatened miscarriage. We aim to establish the distribution of maternal serum progesterone in normal pregnancies compared to pregnancies complicated by threatened miscarriage from 5 to 13 weeks gestation. Read More

Int J Gynaecol Obstet 2018 Dec 21;143(3):289-299. Epub 2018 Sep 21.

Department of Obstetrics and Prenatal Medicine, Univeritair Ziekenhuis Brussel, Vrij Universiteit Brussel, Brussels, Belgium.

Objective: To investigate perceptions of early pregnancy assessment units (EPAUs) among perinatal practitioners working in Belgium, France, and Switzerland.

Methods: A prospective multinational survey was conducted between September 1, 2015, and May 21, 2016. Obstetricians, gynecologists, medical doctors, radiologists, and midwives were recruited during meetings, via e-mail invitations, or through the websites of regional obstetrics and gynecology scientific societies. Read More

Mymensingh Med J 2018 Jul;27(3):544-549

Dr Shereen Yousuf, Medical Officer, Department of Obst & Gynae, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Misoprostol has been widely used in Obstetrics and Gynecology for cervical priming, medical abortion and induction of labour. The purpose of the present study was to evaluate the efficacy and safety of intravaginal misoprostol in mid-trimester medical termination of pregnancy. This non-randomized clinical trial was carried out in the Department of Obstetrics and Gynecology at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from July 2007 to June 2008 for a period of one year. Read More

Mol Cytogenet 2018 17;11:44. Epub 2018 Aug 17.

2Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008 Jiangsu China.

Background: Chromosomal abnormality is one of the major cause of spontaneous abortion. Most available guidelines suggest genetic testing after three miscarriages, which has been proved to be difficult to adhere to and somewhat of low cost-effectiveness. As chromosomal microarray analysis has been recommended to be applied on miscarriage products, we managed a retrospective study on our experience investigate the potential impact of this technique on previous guidelines and our present management on miscarried couples and products. Read More

Biosci Rep 2018 10 17;38(5). Epub 2018 Oct 17.

Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Missed abortion is one of the common complications of assisted reproductive technology (ART). Genetic abnormality is the most important factor. However, the effect of ART on the molecular karyotype of products of conception (POC) remains unknown. Read More

Hum Reprod 2018 10;33(10):1968-1972

Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 82, Aarhus N, Denmark.

Study Question: What is the risk of venous thromboembolism (VTE) in the 12 weeks following early pregnancy loss in pregnancies conceived by IVF?

Summary Answer: The VTE risk is low in the 12 weeks following early pregnancy loss in pregnancies conceived by IVF.

What Is Known Already: There is an excess VTE risk during first trimester in complete IVF pregnancies leading to delivery. It is unknown whether this excess VTE risk also is present in IVF pregnancies terminated by early pregnancy loss (implantation failure, missed abortion, or spontaneous or induced abortion before 10 completed gestational weeks). Read More

Taiwan J Obstet Gynecol 2018 Aug;57(4):605-607

Department of Obstetrics and Gynecology, Mennonite Christian Hospital, Hualien, Taiwan. Electronic address:

Objective: Interstitial pregnancy occurs in the intramural segment of the Fallopian tubes, while angular pregnancy is one that is located in one of the lateral angles of the uterine cavity. The differential diagnosis and treatment of these conditions are important. We have used saline infusion sonohysterography (SIS) to help in differential diagnosis. Read More

J Obstet Gynaecol Can 2018 Aug;40(8):1017-1023

Maternal, Newborn and Teen Program, Department of Obstetrics and Gynaecology, North York General Hospital, Toronto, ON; Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Toronto, Toronto, ON. Electronic address:

Objective: This study sought to evaluate the sustained value of an early pregnancy assessment clinic (EPAC) in the management of early pregnancy complications and its effect on the incidence emergency room (ER) visits.

Methods: A 10-year retrospective study (January 2006 to December 2015) was conducted. The number of patients assessed, sources and reasons for referral, and treatments provided were reviewed. Read More

Contracept Reprod Med 2018 1;3:14. Epub 2018 Aug 1.

2Department of Population and Family Health, Jimma University, Jimma, Ethiopia.

Background: Family planning (FP) program is a key program to avert unbalanced human population growth, maternal mortality, unintended pregnancy, unsafe abortion, sexually transmitted diseases and malnutrition. To address these aims, all services that clients receive must be of consistently high quality. So, services that clients receive should be monitored and evaluated. Read More

Acta Obstet Gynecol Scand 2018 Dec 21;97(12):1491-1498. Epub 2018 Sep 21.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Introduction: Women with miscarriage experience several negative emotional feelings such as grief, isolation, coping, and despair. However, less is known about how the type of treatment and diagnosis of miscarriage influence the emotional experience.

Material And Methods: The present study was a randomized prospective longitudinal cohort study, in which women with spontaneous miscarriage (n = 35), and women with missed miscarriage (n = 67), were included to answer three validated questionnaires: Revised Impact of Miscarriage Scale, Perinatal Grief Scale, and Montgomery and Åsberg Depression Rating Scale, concerning experience of miscarriage, psychological well-being, and mental health 1 week and 4 months after finalized treatment. Read More

Med Hypotheses 2018 Sep 12;118:169-173. Epub 2018 Apr 12.

Department of Physiology and Immunology, Medical Faculty, University of Rijeka, 51000 Rijeka, B. Branchetta 20, Croatia; Department of Biomedical Sciences in Rijeka, Croatian Academy of Sciences and Arts, R. Matejcic 2, 51000 Rijeka, Croatia. Electronic address:

We hypothesize that progesterone causes tolerogenic maturation of myeloid dendritic cells (DCs) in human decidua of threatened miscarriage or missed abortion characterized by a distinct phenotype and cytokine production, including reduction of the main NK cell proliferation and cytotoxic factor interleukin (IL)-15. During DC/NK cell interaction, progesterone-shaped DCs cannot efficiently multiply or equip NK cells with the cytotoxic mediators peforin and granulysin, which might harm trophoblasts and induce abortion. We propose that the presence, and maturation stage of decidual myeloid DCs be investigated using semi-quantitative immunohistological analyses and/or double-color immuno-fluorescent labeling of DC lineage and activation markers. Read More

Mol Med Rep 2018 Aug 21;18(2):2027-2032. Epub 2018 Jun 21.

Department of Obstetrics and Gynecology, Chinese People's Liberation Army (PLA) General Hospital, Chinese PLA Medical School, Beijing 100853, P.R. China.

Missed abortion (MA) refers to a pregnancy in which there is fetal demise without outside intervention, and additionally no uterine activity that may expel the product of conception (POC) prior to 20 weeks of gestation. Chromosomal abnormalities are the primary cause of MA and single gene defects in the POC may additionally be associated with MA; however, few studies have been conducted on the identification of mutations by whole‑exome sequencing. In the present study, 19 unrelated MA POCs were collected and whole‑exome sequencing was performed on the POC. Read More

Arch Gynecol Obstet 2018 Sep 27;298(3):537-543. Epub 2018 Jun 27.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi, China.

Purpose: To analyze the effects of the hypoxia-inducible factor 1-alpha (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway on villous angiogenesis in early missed abortion.

Methods: Immunohistochemical assays were performed to detect the expression of micro-vessel density (MVD), HIF-1α, and VEGF in villous tissue samples from 30 missed abortions and 30 elective abortions in early pregnancy. We further analyzed the correlation between HIF-1α/VEGF and MVD. Read More

JAMA 2018 06;319(24):2497-2506

Center for Applied Studies in Health Economics, Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania.

Importance: Multiple states have laws requiring abortion facilities to meet ambulatory surgery center (ASC) standards. There is limited evidence regarding abortion-related morbidities and adverse events following abortions performed at ASCs vs office-based settings.

Objective: To compare abortion-related morbidities and adverse events at ASCs vs office-based settings. Read More

Vet Med Sci 2018 11 26;4(4):271-279. Epub 2018 Jun 26.

Department of Veterinary Public Health and Preventive Medicine, University of Ilorin, Ilorin, Kwara State, Nigeria.

Tick-borne relapsing fever (TBRF) caused by the bacteria Borrelia, is poorly documented in veterinary medicine. Given the widespread presence of the soft tick vectors - Ornithodoros and the recently discovered hard tick vectors, as well as their close association with animal hosts, it is highly likely that infection occurs, but is rarely reported to be of veterinary importance. Sporadic reports of canine infection, some being fatal through to probable cause of abortion in horses have been published. Read More

Fertil Steril 2018 06;109(6):1060-1064

Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, New York.

Objective: To determine if alpha-fetoprotein (AFP) concentration in vaginal blood, in the setting of dissolved fetal tissue, is significantly higher than its concentration in the maternal serum.

Design: A prospective cohort study.

Setting: Medical center. Read More

J Assist Reprod Genet 2018 Jun 18. Epub 2018 Jun 18.

Department of Obstetrics and Gynecology, Danube Hospital, Langobardenstrasse, 122, Vienna, Austria.

Purpose: The aim of the study was to assess cytogenetic and embryoscopic characteristics in subsequent miscarriages of spontaneous pregnancy losses (SPL) and recurrent pregnancy losses (RPL).

Methods: A retrospective cohort of 75 women was affected by repeated pregnancy loss. Of those, 34 had SPL, 24 primary RPL, and 17 secondary RPL. Read More

J Minim Invasive Gynecol 2018 Jun 8. Epub 2018 Jun 8.

Department of Obstetrics and Gynecology, Division of Minimally Invasive Gynecology, Uludag University Hospital, Bursa, Turkey (all authors).

Study Objective: Minimally invasive surgical procedures have shown significant improvement over the last 20 years. Today, nearly half of the surgeries, including oncology, are performed with minimally invasive methods. In obstetrics and gynecology surgery practice, laparoscopy can now be used in almost all operations. Read More

J Matern Fetal Neonatal Med 2018 Jul 18:1-8. Epub 2018 Jul 18.

a Department of Obstetrics & Gynecology, Woman's Health Hospital, Faculty of Medicine , Assiut University , Assiut , Egypt.

Objective: To determine whether the traction placed on a transcervical Foley catheter balloon inserted for the induction of mid-trimester missed abortion results in faster time of abortion.

Study Design: It was randomized clinical trial conducted at Assiut Woman's Health Hospital, Egypt, from September 2016 to August 2017 on women with missed abortion in the mid-trimester. Participants were randomly assigned to transcervical Foley catheter balloon insertion with or without traction. Read More

Taiwan J Obstet Gynecol 2018 Jun;57(3):427-431

Department of Clinical Biochemistry, Kayseri Training and Research Hospital, Kayseri, Turkey.

Objective: To evaluate serum dynamic thiol/disulphide concentrations in patients with suspected missed abortion (MA) and to determine whether this ratio has a predictive role in the viability in these pregnancies.

Materials And Methods: In this prospective cohort study, 48 out of 120 recruited pregnant patients were confirmed MA in the study group. Following the recommended waiting time (7-10 days), the remaining 72 viable pregnancies that met the inclusion criteria were categorized as the control group. Read More

Zhonghua Fu Chan Ke Za Zhi 2018 May;53(5):308-312

Department of Obstetric and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To investigate the value of bacterial artificial chromosome-on-beads (BoBs) technology in the genetic analysis of early missed abortion chorionic villi. Early missed abortion chorionic villi were detected with both conventional karyotyping method and BoBs technology in Peking Union Medical Hospital from July 2014 to March 2015. Compared the results of BoBs with conventional karyotyping analysis to evaluate the sensitivity, specificity and accuracy of this new method. Read More

Am J Reprod Immunol 2018 Sep 18;80(3):e12978. Epub 2018 May 18.

Medical Faculty, Department of Physiology and Immunology, University of Rijeka, Rijeka, Croatia.

Problem: Granulysin (GNLY) is a cytotoxic molecule mostly present in decidual natural killer (NK) cells. Blighted ovum (BO) and missed abortion (MA) represent the early pathological pregnancies with hindered development of the embryoblast or a dead embryo. We investigated the GNLY-mediated apoptotic mechanism potentially responsible for delayed termination of pregnancy. Read More

J Ultrasound Med 2018 Dec 17;37(12):2841-2847. Epub 2018 Apr 17.

Division of Prenatal Medicine, Department of Obstetrics and Gynecology, University of Schleswig-Holstein, Luebeck, Germany.

Objectives: The aim of this study was to evaluate the feasibility of sonographic assessment of the embryonic/fetal neural tube in nonviable pregnancies and to determine the defect incidence.

Methods: Prospective analysis of transvaginally acquired 3-dimensional (3D) multiplanar and 3D surface-rendered volume sets of 340 cases of missed abortion between March 2010 and September 2015 was performed. Data regarding karyotype and postmortem examination as well as demographic features and the outcomes of subsequent pregnancies were evaluated. Read More

Eur J Med Res 2018 Apr 16;23(1):17. Epub 2018 Apr 16.

Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Objectives: The purpose of this study was to evaluate the clinical characteristics, prenatal diagnosis, and management of patients with heterotopic pregnancy after ovulation induction or embryo transfer.

Methods: This was a retrospective study of fifty cases with heterotopic pregnancy, in which the fertilization way, type and number of embryo transferred, gestational age, clinical presentation and outcome of intrauterine, ultrasound presentation and site of ectopic pregnancy, bilateral fallopian tube and treatment were evaluated.

Results: Six patients had spontaneous pregnancy and two had artificial insemination after ovulation induction. Read More

Zhonghua Fu Chan Ke Za Zhi 2018 Mar;53(3):155-159

Prenatal Diagnosis Center, Jinhua Maternal and Child Health Care Hospital, Jinhua 321000, China.

To explore the occurrence of fetal chromosomal abnormalities among pregnant women with an adverse reproductive history using traditional karyotyping and single nucleotide polymorphism microarray (SNP-array) technology. Totally 94 in 2 163 (4.35%) cases of singleton pregnant women with an adverse reproductive history were performed amniocentesis in Jinhua Maternal and Child Health Care Hospital from June 2015 to June 2017. Read More

J Reprod Immunol 2018 Jun 16;127:55-57. Epub 2018 Mar 16.

Department of Pathology and Molecular Medicine, McMaster University, Canada.

Presence of the CD200 immune check-point inhibitor at the feto-maternal interface is linked to prevention of spontaneous abortion in mice and humans. In human missed abortions (MA), absence of Th17-driven inflammation has been attributed to expression of villus trophoblast CD200 quantified using immunohistochemistry. While rapid aneuploidy (QF-PCR) testing linked low CD200 to pregnancy failure, data showing normal VT CD200 in first trimester normal pregnancy and in abortion of chromosomally abnormal embryos has not been demonstrated. Read More

Obstet Gynecol Sci 2018 Mar 2;61(2):220-226. Epub 2018 Mar 2.

Department of Obstetrics and Gynecology, Seoul Metropolitan-Government Seoul National University Boramae Medical Center, Seoul, Korea.

Objective: This study was conducted to determine the effectiveness and safety of medical treatment with sublingual misoprostol (MS) in the 1st trimester miscarriage under the approval by Health Insurance Review and Assessment Service (HIRA) for off-label usage by the single medical center in Korea.

Methods: A retrospective cohort study was performed in one institution between April 2013 and June 2016. Ninety-one patients diagnosed with miscarriage before 14 weeks of gestation and wanted to try medical treatment were included. Read More

Eur J Obstet Gynecol Reprod Biol 2018 May 5;224:1-5. Epub 2018 Mar 5.

Department of Obstetrics and Gynecology, Assaf Harofe Medical Center (Affiliated with the Sackler Faculty of Medicine), Tel Aviv University, Tel Aviv, Israel.

Objective: To investigate whether women who were surgically treated for retained products of conception (RPOC) by either suction curettage or hysteroscopy are at risk for recurrent RPOC on their subsequent pregnancies.

Study Design: Retrospective analysis of 442 women surgically treated for RPOC following delivery or abortion by suction curettage (N = 63, 14.3%) or hysteroscopy (N = 379, 85. Read More

Zhejiang Da Xue Xue Bao Yi Xue Ban 2017 May;46(5):529-536

Department of Gynecology and Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.

Objective: To analyze the clinical features, diagnosis and treatment of gestational trophoblastic diseases in cesarean scar.

Methods: Clinical data of three cases of gestational trophoblastic diseases in cesarean scar diagnosed in Women's Hospital, Zhejiang University School of Medicine during December 2011 and December 2016 were collected. And literature search was performed in Wanfang data, VIP, CNKI, PubMed, ISI Web of Knowledge and EMbase database. Read More

J Coll Physicians Surg Pak 2018 Mar;28(3):S33-S34

Department of Obstetrics and Gynecology, The Aga Khan University Hospital, Karachi.

Uterine arteriovenous malformation (AVM) is an uncommon but life-threating source of bleeding. AVM is an abnormal connection between uterine arteries and veins. Patients typically present with vaginal bleeding following miscarriage (medical/surgical) or cesarean section. Read More

BMC Womens Health 2018 02 17;18(1):41. Epub 2018 Feb 17.

African Population and Health Research Center, 2nd Floor APHRC Campus, Manga Close Off Kirawa Road, P.O. Box 10787-00100, Nairobi, Kenya.

Background: Complications of unsafe abortion are a leading cause of maternal mortality in sub-Saharan Africa. Adolescents and young women are disproportionately represented among those at risk of these complications. Currently, we know little about the factors associated with young women's timing of abortion. Read More

Medicine (Baltimore) 2017 Dec;96(51):e9388

School of Public Health, Guangxi Medical University.

To assess the association between exposure to the tobacco, heavy metals and phthalate on early pregnancy and missed abortion.42 women with missed abortion and 57 matched controls (women with normal pregnancies) were recruited between March and May 2012, from the Department of Gynecology and Obstetrics, First Affiliated Hospital of Guangxi Medical University and the People Hospital of Guangxi Zhuang Autonomous Region. The questionnaire survey was carried on to learn about the basic conditions, as well as smoking history of all participants. Read More

Biochem Biophys Res Commun 2018 02 17;496(2):679-685. Epub 2018 Jan 17.

Department of Obstetrics and Gynaecology, The Fifth People's Hospital of Shanghai, School of Medicine, Fudan University, Shanghai, People's Republic of China. Electronic address:

A missed abortion (MA) is an in-utero death of the embryo or fetus before the 20th week of gestation with retained products of conception. In order to discover novel biomarkers for MA, a H NMR spectroscopy-based metabolomics approach was applied to detect human MA serum metabolic profiles. Serum samples were obtained from patients with MA (n = 15) and healthy controls (n = 9) for study. Read More

Gynecol Obstet Fertil Senol 2018 Feb 17;46(2):86-92. Epub 2018 Jan 17.

Maternité du CHRU Nancy, 10, rue du Docteur-Heydenreich, 54000 Nancy, France; Université de Lorraine, 9, avenue de la Forêt-de-Haye, 54505 Vandœuvre-lès-Nancy, France.

Objective: Ultrasound examination plays a central role in case of suspected non-viable pregnancy. A wrong diagnosis might have major consequence in terms of inadequate care, especially in cases of false positive non-viable pregnancy diagnosis. Ultrasound criterions are today well defined. Read More

Prenat Diagn 2018 02 31;38(3):204-209. Epub 2018 Jan 31.

Department of Obstetrics & Gynecology, Columbia University Medical Center, New York, NY, USA.

Objective: To determine how frequently and effectively products of conception can be obtained among women pursuing medical management of early pregnancy loss.

Methods: This pilot study was conducted to assess products of conception recovery outcomes for participants opting for medical management compared with women opting for surgical aspiration A tissue-collection kit was provided to women opting for medical management. Outcome measures included successful collection of products of conception, quantity and integrity of DNA, and participant satisfaction with the process. Read More

Ginekol Pol 2017 ;88(12):654-661

Objectives: To investigate the clinical features, disposition, and effect of pregnancy complicated with Takayasu arteritis (P-TA) on maternal and fetal outcomes.

Material And Methods: The clinical data (diagnosis and treatment, peri-pregnancy monitoring, and pregnancy outcomes) of patients with P-TA treated in our hospital between September 2007 and April 2016 were analyzed retrospectively.

Results: Among the 13 P-TA cases, seven were diagnosed before pregnancy, and six were diagnosed during pregnancy; six cases were diagnosed as the generalized type, and seven cases were diagnosed as the cephalic-brachial type; six cases were in the stable stage, and seven cases were in the active stage. Read More

Gynecol Endocrinol 2017 ;33(sup1):36-40

c Department of Obstetrics and Gynecology , Dagestan State Medical Academy , Makhahkala , Russia.

To evaluate the prognostic value of a comprehensive endometrial study after early reproductive losses (RL). A group of 306 women with early RL (missed abortion (n = 120), spontaneous miscarriage (n = 120), and ineffective in vitro fertilization attempts (n =66) were prospectively examined up to 6 months after the discharge of the uterus at the hospital bases of the Department of Obstetrics and Gynecology with the Сourse of perinatology at the PFUR Medical Faculty. Hysteroscopic macrotypes differentiation - hyperplastic (n = 89), hypoplastic (n = 94) and mixed (n = 87) - was carried out on the basis of features grouping characterizing the thickness, color and structure of the mucosa, the intensity of a vascular pattern in the presence of a chronic endometritis (CE). Read More

Gynecol Endocrinol 2017 ;33(sup1):32-35

e Scientist of the Laboratory of Genetics , FSBI "Urals Scientific Research Institute for Maternal and Child Care" of Ministry of Healthcare of the Russian Federation , Yekaterinburg , Russia.

The performed clinical laboratory and instrumental research involved 93 pregnant women after IVF: 36 with progressive pregnancy and 57 women with missed abortion at term 6-8 weeks. The following parameters were evaluated: family history of thrombosis, menstrual function, gynecological and other diseases, duration of infertility treatment, pelvic organs sonography, hemostasis evaluation and thrombophilia genes investigation. The association of polymorphic allele 455 A of gene FGB with the risk of nondeveloping pregnancy after IVF was revealed. Read More

Clin Med (Lond) 2017 Dec;17(6):581-583

Basildon University Hospital, Basildon and Thurrock NHS Foundation Trust.

A nine-week pregnant 33-year-old female presented with sudden-onset right-sided hemiparesis, hemisensory loss, dysarthria and homonymous hemianopia. She was known to have eleven previous miscarriages and used recreational drugs. A CT-head was unremarkable. Read More

Case Rep Obstet Gynecol 2017 18;2017:6070732. Epub 2017 Oct 18.

Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Background: The detection of a morbidly adherent placenta (MAP) in the first trimester is rare. Risk factors such as multiparity, advanced maternal age, prior cesarean delivery, prior myomectomy, placenta previa, or previous uterine evacuation place patients at a higher risk for having abnormal placental implantation. If these patients have a first trimester missed abortion and fail medical management, it is important that providers have a heightened suspicion for a MAP. Read More