41,847 results match your criteria Missed Abortion


Topographical distribution of sentinel nodes and metastases from T1-T2 oral squamous cell carcinomas.

Eur J Cancer 2018 Dec 12;107:86-92. Epub 2018 Dec 12.

Department of Plastic and Reconstructive Surgery, Odense University Hospital, Denmark.

Objective: The objective is to investigate the topographical distribution of sentinel nodes (SNs) and lymph node metastases in T1-2cN0 oral squamous cell carcinomas (OSCCs).

Methods: The study entailed a prospective enrolment of 220 patients with clinical T1-2N0 OSCCs who underwent preoperative lymphoscintigraphy (LSG) followed by gamma probe-guided sentinel lymph node biopsy (SLNB). Patients with positive SNs were treated with completion neck dissection. Read More

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December 2018

Missed at first Glanz: Glanzmann thrombasthenia initially misdiagnosed as Von Willebrand Disease.

Transfus Apher Sci 2018 Dec 5. Epub 2018 Dec 5.

National Coagulation Centre, St James's Hospital, Dublin 8, Ireland; Irish Centre for Vascular Biology, Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland. Electronic address:

Glanzmann thrombasthenia (GT) is an autosomal recessive bleeding disorder caused by a defect in platelet integrin αIIbβ3. Given the rarity of the condition (1/1,000,000), assessment and diagnosis should be undertaken in a specialist centre. We report the case of a 34 year old woman with severe menorrhagia and a childhood diagnosis from another centre of Von Willebrand Disease. Read More

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December 2018

Reversing wetland death from 35,000 cuts: Opportunities to restore Louisiana's dredged canals.

PLoS One 2018 14;13(12):e0207717. Epub 2018 Dec 14.

University of Central Florida, Orlando, Florida, United States of America.

We determined the number of permits for oil and gas activities in 14 coastal Louisiana parishes from 1900 to 2017, compared them to land loss on this coast, and estimated their restoration potential. A total of 76,247 oil and gas recovery wells were permitted, of which 35,163 (46%) were on land (as of 2010) and 27,483 of which are officially abandoned. There is a direct spatial and temporal relationship between the number of these permits and land loss, attributable to the above and belowground changes in hydrology resulting from the dredged material levees placed parallel to the canal (spoil banks). Read More

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December 2018
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Impact of Patient Safety Culture on Missed Nursing Care and Adverse Patient Events.

J Nurs Care Qual 2018 Dec 12. Epub 2018 Dec 12.

Columbia University, School of Nursing, New York, New York (Dr Hessels); Ann May Center for Nursing and Allied Health, Hackensack Meridian Health, Neptune, New Jersey (Drs Hessels, Weaver, and Wurmser); Institute of Evidence-Based Care, Hackensack Meridian Health, Neptune, New Jersey (Ms Paliwal); and Medical Services Division, United Nations, New York, New York (Dr Siddiqui).

Background: A strong patient safety culture (PSC) may be associated with improved patient outcomes in hospitals. The mechanism that explains this relationship is underexplored; missed nursing care may be an important link.

Purpose: The purpose of this study was to describe relationships among PSC, missed nursing care, and 4 types of adverse patient events. Read More

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December 2018

Regionalization of Retroperitoneal Sarcoma Surgery to High-Volume Hospitals: Missed Opportunities for Outcome Improvement.

J Oncol Pract 2018 Dec 14:JOP1800349. Epub 2018 Dec 14.

MedStar-Georgetown Surgical Outcomes Research Center; MedStar-Georgetown University Hospital; Medstar-Washington Hospital Center; Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC; and MedStar Health Research Institute, Hyattsville, MD.

Purpose:: Surgery continues to be the dominant therapy for the management of retroperitoneal soft-tissue sarcoma (RPS). Many groups advocate performing these resections at high-volume hospitals (HVHs), given their complexity. We therefore sought to explore whether RPS surgery has indeed begun to regionalize to HVHs in the same manner as pancreatic cancer (PC) surgery during the last decade. Read More

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December 2018

[Nasal acinar cell carcinoma:a case report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1834-1835

Acinar cell carcinoma is a rare type of low-grade malignant tumor of the parotid gland epithelium. The progression of the disease is slow, and its tissue type and cell morphology are diverse. The diagnosis of tumor is difficult so that it is easy to cause missed diagnosis and misdiagnosis. Read More

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December 2018

[Clincal analysis of missed diagnosis and misdiagnosis of benign paroxysmal positional vertigo].

Authors:
X Wang Y S Xu

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1904-1905

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December 2018

Systematic review and meta-analysis on the role of prenatal magnetic resonance imaging in the era of fetal neurosonography: mild and moderate ventriculomegaly.

Ultrasound Obstet Gynecol 2018 Dec 14. Epub 2018 Dec 14.

Women´s Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway.

Objectives: To report the rate of additional anomalies detected exclusively on prenatal MRI in fetuses affected by isolated mild or moderate ventriculomegaly (VM) according to the type of ultrasound protocol adopted (dedicated neurosonography vs standard assessment of fetal brain) and to explore whether the diagnostic performance of fetal MRI in detecting such anomalies is affected by gestational age at scan and laterality of ventricular dilatation.

Methods: The primary aim was to report the rate of additional anomalies detected exclusively on prenatal MRI in fetuses affected by isolated mild and moderate VM (ventricular dilatation between 10-15 mm) undergoing compared to those not undergoing dedicated neurosonography, defined as a detail assessment of fetal brain according to the International Society of Ultrasound in Obstetrics and Gynecology guidelines. Medline, Embase, Cinahl and Clinicaltrials. Read More

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December 2018

The effect of a teamwork intervention on staff perception of teamwork and patient care on a medical surgical unit.

Nurs Forum 2018 Dec 12. Epub 2018 Dec 12.

School of Nursing, Western Kentucky University, Bowling Green, Kentucky.

As a result of the ever-changing health care environment and patient complexity, it is difficult for nursing teams to provide safe quality care and complete all tasks, also known as missed nursing care. Missed nursing care is a global health care issue and defined as any aspect of care missed in part, in whole, or delayed. Teamwork has been found to not only positively impact the performance of a team, but also patient outcomes. Read More

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December 2018

Point-of-care ultrasonography for diagnosing thoracoabdominal injuries in patients with blunt trauma.

Cochrane Database Syst Rev 2018 Dec 12;12:CD012669. Epub 2018 Dec 12.

Centre for Clinical Research, Department of Trauma and Orthopaedic Surgery, Unfallkrankenhaus Berlin, Berlin, Germany, 12683.

Background: Point-of-care sonography (POCS) has emerged as the screening modality of choice for suspected body trauma in many emergency departments worldwide. Its best known application is FAST (focused abdominal sonography for trauma). The technology is almost ubiquitously available, can be performed during resuscitation, and does not expose patients or staff to radiation. Read More

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December 2018

Posterior cord syndrome associated with postoperative seroma: The case to perform a complete neurologic exam.

J Spinal Cord Med 2018 Dec 14:1-3. Epub 2018 Dec 14.

b Physical Medicine and Rehabilitation Department , Tufts Medical Center , Boston , Massachusetts , USA.

Context: Posterior cord syndrome (PCS) is the least common incomplete spinal cord injury. Findings of posterior cord syndrome include loss of proprioception and vibration, which are not routinely tested with the American Spinal Cord Injury Association's International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) exam and can easily be missed. Seromas may develop after spinal instrumentation and can cause cord compression. Read More

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December 2018

Recurrent coronary artery dissection of left main trunk initially presented with normal coronary angiography.

J Cardiol Cases 2016 Dec 7;14(6):164-167. Epub 2016 Sep 7.

Division of Cardiovascular Medicine and Coronary Heart Disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

Although spontaneous coronary artery dissection (SCAD) is usually diagnosed by coronary angiography, diagnosis may be missed because of various presentations and imperfections of coronary angiography. We report a case of a 41-year-old female with pregnancy-related SCAD who presented with cardiac arrest. Initial coronary angiography was normal without intimal flap. Read More

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December 2016

Tetralogy of Fallot associated with supramitral ring: "Paying for a near miss".

J Cardiol Cases 2015 Nov 22;12(5):159-161. Epub 2015 Jul 22.

Nizam's Institute of Medical Sciences, Hyderabad, India.

A 13-year-old girl developed the features of congestive heart failure on day three of intracardiac repair of tetralogy of Fallot. A routine transthoracic echocardiography identified the missed supramitral ring (SMR), closely placed just above the mitral valve, the very reason for severe mitral stenosis and its implication in the present clinical deterioration. A rare association of SMR with tetralogy of Fallot may be missed narrowly because closely placed SMR can sometimes mask its hemodynamic effect when present with significant right ventricular outflow tract obstruction as in this case. Read More

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November 2015

A covert complication of arteriovenous fistulas.

J Cardiol Cases 2015 May 21;11(5):132-135. Epub 2015 Feb 21.

Department of Medicine, New Jersey Medical School Rutgers, The State University of New Jersey, Newark, NJ, USA.

Our patient is a 65-year-old man with a history of hypertension, aortic stenosis, and end-stage renal disease on hemodialysis who presented with worsening dyspnea. On examination, he exhibited signs of volume overload and had a radiocephalic arteriovenous fistula (AVF) with a significantly palpable thrill. Coronary angiogram showed normal coronary arteries. Read More

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Left atrial myxoma development after radiofrequency ablation of an atrial flutter substrate.

J Cardiol Cases 2015 Apr 20;11(4):124-126. Epub 2015 Feb 20.

Geriatrics-Rehabilitative Department, Italian National Research Center on Aging (I.N.R.C.A.), Fermo, Italy.

A 51-year-old man developed symptoms (palpitations) related to a large left atrial mass attached to interatrial septum discovered by trans-thoracic heart ultrasonography. Six months earlier this patient had undergone radiofrequency ablation (RFA) of an atrial flutter substrate. The left atrial mass was removed surgically using cardiopulmonary bypass with disappearance of symptoms. Read More

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Serendipitous diagnosis of cor triatriatum sinister in a child with Kawasaki disease.

J Cardiol Cases 2015 Jan 11;11(1):14-17. Epub 2014 Nov 11.

Division of Pediatric Cardiology, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea.

Cor triatriatum is a rare congenital anomaly which has wide-ranging severity depending on the structure of the additional intra-atrial septum. We report the case of a boy who was incidentally diagnosed with cor triatriatum by echocardiography during diagnosis and treatment of Kawasaki disease. He has had no definite life-threatening symptoms except recurring respiratory infections. Read More

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January 2015

Left ventricular apical aneurysm in chronic Chagas cardiomyopathy-A case report.

J Cardiol Cases 2014 Sep 14;10(3):88-90. Epub 2014 Jul 14.

Department of Cardiology, Jackson Memorial Hospital, Miami, FL, USA.

A 56-year-old female, who immigrated to the USA from Honduras, presented with worsening shortness of breath, orthopnea, paroxysmal nocturnal dyspnea, and decreased exercise tolerance over the previous 2 months. She was diagnosed 1 year previously with non-ischemic dilated cardiomyopathy and non-sustained monomorphic ventricular tachycardia. An implantable cardioverter defibrillator was placed. Read More

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September 2014

Coping with Asthma in Racially and Ethnically Diverse Urban Children: The Role of Emotional Problems in Disease Control.

Child Health Care 2017 16;46(2):151-169. Epub 2016 May 16.

Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois.

This study examined cross-sectional associations among coping, mental health, and asthma outcomes in racially/ethnically diverse urban children. Children (N=42; 65% female) ages 9 to 17 (M=11.9) years old and their parents reported on the child's coping, emotional and conduct problems, asthma control, and school missed due to asthma. Read More

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Assessment of body force effects in flow condensation, part II: Criteria for negating influence of gravity.

Int J Heat Mass Transf 2017 Feb 26;106:313-328. Epub 2016 Jul 26.

Boiling and Two-Phase Flow Laboratory (BTPFL), School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN 47907, USA.

This study concerns the development of a set of mechanistic criteria capable of predicting the flow conditions for which gravity independent flow condensation heat transfer can be achieved. Using FC-72 as working fluid, a control-volume based annular flow model is solved numerically to provide information regarding the magnitude of different forces acting on the liquid film and identify which forces are dominant for different flow conditions. Separating the influence of body force into two components, one parallel to flow direction and one perpendicular, conclusions drawn from the force term comparison are used to model limiting cases, which are interpreted as transition points for gravity independence. Read More

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February 2017

Use of “Months of the Year Backwards” (MOTYB) as a Screening Tool for Delirium in Palliative Care Patients in the Acute Hospital Setting

Ir Med J 2018 09 10;111(8):801. Epub 2018 Sep 10.

University Hospital Waterford

Introduction Delirium is common in palliative care. It effects up to 88% of patients with advanced cancer at end of life and has a point prevalence of 20% in the acute hospital setting across all diagnoses. It is under diagnosed and not optimally treated. Read More

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September 2018

Primary hypophysitis and other autoimmune disorders of the sellar and suprasellar regions.

Rev Endocr Metab Disord 2018 Dec 13. Epub 2018 Dec 13.

Medicover GmbH, Berlin/Hannover, Germany.

The pituitary gland and the hypothalamus can be affected by autoimmune-mediated structural and functional disruption. These autoimmune-mediated diseases occur more commonly in females and are often found during pregnancy or in the post-partum period. Autoimmune diseases can either affect parts of the pituitary or hypothalamus, or can involve both sellar and suprasellar structures. Read More

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December 2018
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The Morel-Lavallée lesion in thoracolumbar spine trauma-two index cases.

J Spine Surg 2018 Sep;4(3):654-657

Department of Neurosurgery, Royal North Shore Hospital, Sydney, Australia.

The Morel-Lavallée lesion (MLL) is a closed degloving injury caused by traumatic separation of the subcutaneous tissue from the underlying fascia, without a break in the overlying skin. We present two cases that demonstrate a previously unrecognised association of the MLL with thoracolumbar spine fractures. The lesion is frequently missed, or its significance is overlooked, on initial evaluation. Read More

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September 2018

An AI-Based Heart Failure Treatment Adviser System.

IEEE J Transl Eng Health Med 2018 23;6:2800810. Epub 2018 Nov 23.

Computer Science DepartmentThe University of Texas at DallasRichardsonTX75080USA.

Management of heart failure is a major health care challenge. Healthcare providers are expected to use best practices described in clinical practice guidelines, which typically consist of a long series of complex rules. For heart failure management, the relevant guidelines are nearly 80 pages long. Read More

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November 2018

Utility of Magnetic Resonance Imaging Brain Epilepsy Protocol in New-Onset Seizures: How is it Different in Developing Countries?

J Clin Imaging Sci 2018 15;8:43. Epub 2018 Nov 15.

Department of Radiodiagnosis, Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka, India.

Introduction: Magnetic resonance imaging (MRI) is the current imaging tool of choice in the investigation of patients with seizures. The advent of high-resolution MRI with a dedicated seizure protocol has significantly increased the chances of identifying a cause, resulting in a positive clinical impact on the management of these patients.

Aims: The aims of this study were to evaluate the diagnostic efficacy of standard MRI, identify whether there is an increase in the diagnostic yield with the addition of dedicated seizure protocol, and compare the diagnostic yields of MRI and electroencephalogram (EEG) individually and in combination. Read More

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November 2018

Multiple well-differentiated cardiac liposarcoma with a concomitant myocardial lipoma: A case report.

Mol Clin Oncol 2018 Dec 5;9(6):617-621. Epub 2018 Oct 5.

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.

A cardiac lipoma and a cardiac liposarcoma are very uncommon conditions; however, the simultaneous development of the two is extremely rare. In addition, the symptoms of these conditions are not evident in the vast majority of cases, making them easily missed during diagnosis. The present case report describes a case of well-differentiated cardiac liposarcoma with a concomitant myocardial lipoma that was misdiagnosed as multiple cardiac lipomas. Read More

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December 2018

Evaluation of an educational intervention to increase HIV-testing in high HIV prevalence general practices: a pilot feasibility stepped-wedged randomised controlled trial.

BMC Fam Pract 2018 Dec 13;19(1):195. Epub 2018 Dec 13.

Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.

Background: HIV-infected patients often present to primary care several times with HIV-indicator conditions before diagnosis but the opportunity to test by healthcare professionals (HCPs) is frequently missed. Current HIV testing rates in primary care are low and educational interventions to facilitate HCPs to increase testing and awareness of HIV are needed.

Method: We implemented a pilot feasibility stepped-wedged randomised controlled trial of an educational intervention in high HIV prevalence practices in Bristol. Read More

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December 2018
1 Read

Small Airway Disease in Pulmonary Hypertension-Additional Diagnostic Value of Multiple Breath Washout and Impulse Oscillometry.

J Clin Med 2018 Dec 9;7(12). Epub 2018 Dec 9.

1st Department of Medicine (Cardiology, Angiology, Pulmonary and Intensive Care), University Medical Center Mannheim, 68135 Mannheim, Germany.

Airways obstruction is frequent in patients with pulmonary hypertension (PH). Small airway disease (SAD) was identified as a major contributor to resistance and symptoms. However, it is easily missed using current diagnostic approaches. Read More

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December 2018

Identification of Patients At-Risk of QT Interval Prolongation during Medication Reviews: A Missed Opportunity?

J Clin Med 2018 Dec 10;7(12). Epub 2018 Dec 10.

Faculty of Health, University of Canberra, Bruce, ACT 2617, Australia.

The prolongation of the QT interval is a relatively rare but serious adverse drug reaction. It can lead to torsade de pointes, which is potentially life-threatening. The study's objectives were: determine the use of QT interval-prolonging drugs in an elderly community-dwelling population at risk of medication misadventure and identify recommendations regarding the risk of QT interval prolongation made by pharmacists when performing medication reviews. Read More

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December 2018

Family Practice Research in low-resource settings: what we have missed and what we have to know.

Fam Pract 2018 Dec 13. Epub 2018 Dec 13.

Clinic of Social and Family Medicine, School of Medicine, University of Crete, Heraklion, Greece.

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December 2018

The potential of reducing AST testing in hospital settings.

Clin Biochem 2018 Dec 10. Epub 2018 Dec 10.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada; McMaster University Medical Centre, Hamilton Health Sciences, Hamilton, Ontario, Canada.

Background: Aspartate aminotransferase (AST) is regularly ordered with alanine aminotransferase (ALT) to assess liver integrity. In many situations, AST testing provides little or no added clinical value, since ALT is more specific and the both enzyme activities highly correlate. The objective of this study is to determine the potential reduction in AST testing, if not performed when ALT results are within reference intervals (RI). Read More

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December 2018

Acceptable medication non-adherence: A crowdsourcing study among French physicians for commonly prescribed medications.

PLoS One 2018 13;13(12):e0209023. Epub 2018 Dec 13.

METHODS Team, Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), INSERM, UMR 1153, Paris, France.

Background: Achieving good medication adherence is a major challenge for patients with chronic conditions. Our study aimed to assess the Threshold for Unacceptable Risk of Non-adherence (TURN), defined as the threshold at which physicians consider the health risks incurred by patients due to medication non-adherence unacceptable, for the most commonly prescribed drugs in France.

Methods: We conducted an online study using a crowdsourcing approach among French general practitioners and specialists from September 2016 to August 2017. Read More

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December 2018

Are we aiming to miss in translational autoimmunity treatments?

F1000Res 2018 6;7:1754. Epub 2018 Nov 6.

Webb-Waring Center, University of Colorado, Anschutz Medical Campus, Aurora, CO, 80045, USA.

Autoimmunity treatments, fruitfully pioneered in mouse models, can be disappointing or result in immunosuppression and opportunistic infections in translational trials. Many possible reasons exist, but one major, overlooked reason may be the treatment timing in relation to circadian oscillations of the immune system. Mice and humans both have immunological circadian clocks and experience the same circulatory oscillations of immune cells with regards to their sleep/wake phases, but have opposite sleep/wake phases with regard to the daylight cycle. Read More

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November 2018

Communication between Audiologist, Patient, and Patient's Family Members during Initial Audiology Consultation and Rehabilitation Planning Sessions: A Descriptive Review.

J Am Acad Audiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Speech and Hearing Sciences, Lamar University, Beaumont, TX.

Background: Communication during clinical consultations is an important factor that facilitates decision-making by patients and family members. For clinicians, these interactions are opportunities to build rapport and to facilitate appropriate decision-making.

Purpose: This article presents the literature review of studies focusing on communication between audiologist, patients, and their family members during initial audiology consultations and rehabilitation planning sessions. Read More

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November 2018

Impact of engaging security personnel on access and polio immunization outcomes in security-inaccessible areas in Borno state, Nigeria.

BMC Public Health 2018 Dec 13;18(Suppl 4):1311. Epub 2018 Dec 13.

World Health Organization Country Representative's Office, Abuja, Nigeria.

Background: Nigeria was polio free for almost 2 years but, with the recent liberation of areas under the captivity of insurgents, there has been a resurgence of polio cases. For several years, these inaccessible areas did not have access to vaccination due to activities of Bokoharam, resulting in a concentration of a cohort of unvaccinated children that served as a polio sanctuary. This article describes the processes of engagement of security personnel to access security-compromised areas and the impact on immunization outcomes. Read More

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December 2018

Prevalence, Morphology, Embryogenesis, and Diagnostic Utility of Umbilical Cord Vitelline Vascular Remnants.

Authors:
James R Wright

Pediatr Dev Pathol 2018 Dec 12:1093526618811734. Epub 2018 Dec 12.

1 Department of Pathology & Laboratory Medicine, University of Calgary/Calgary Laboratory Services, Alberta Children's Hospital, Calgary, Alberta, Canada.

The objective of this study is to better understand embryonic vitelline vascular remnants in the umbilical cord, to assess their prevalence, to categorize their morphology, and then finally to describe and assess inflammation arising from these structures. During routine placental sign out, the author noted the presence or absence of vitelline vessel remnants for 1 year; when present, he assessed their histologic patterns and noted whether there were neutrophils marginating from the remnants and into the adjacent Wharton's jelly and whether there was any other evidence of amniotic fluid infection in sections of placental disc, membranes, or cord. All cord sections with vitelline vessel remnants were immunostained for CD15 to document any infiltrates, to highlight patterns of infiltration, and to evaluate whether mild cases of umbilical phlebitis were associated with these lesions and were at risk of being missed. Read More

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December 2018

Eye tracking technology in sports-related concussion: a systematic review and meta-analysis.

Physiol Meas 2018 Nov 8. Epub 2018 Nov 8.

Sports Science, Stellenbosch University Faculty of Education, Matieland, SOUTH AFRICA.

Objective: The development of objective quantitative tools for the assessment and monitoring of sports-related concussion is critical. Eye tracking is a novel tool that may provide suitable metrics. The aim of this review was to appraise current evidence for the use of eye tracking technology in sports-related concussion assessment and monitoring. Read More

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November 2018

The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number.

Dev Cell 2018 Dec 25;47(5):576-591.e8. Epub 2018 Oct 25.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

The Hippo pathway controls the activity of YAP/TAZ transcriptional coactivators through a kinase cascade. Despite the critical role of this pathway in tissue growth and tumorigenesis, it remains unclear how YAP/TAZ-mediated transcription drives proliferation. By analyzing the effects of inactivating LATS1/2 kinases, the direct upstream inhibitors of YAP/TAZ, on mouse brain development and applying cell-number-normalized transcriptome analyses, we discovered that YAP/TAZ activation causes a global increase in transcription activity, known as hypertranscription, and upregulates many genes associated with cell growth and proliferation. Read More

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December 2018

Utility of the Seattle Heart Failure Model for palliative care referral in advanced ambulatory heart failure.

BMJ Support Palliat Care 2018 Dec 6. Epub 2018 Dec 6.

Division of Cardiology, Toronto General Hospital - University Health Network, Toronto, Ontario, Canada.

Background: Physicians face uncertainty when predicting death in heart failure (HF) leading to underutilisation of palliative care. To facilitate decision-making, we assessed the Seattle Heart Failure Model (SHFM) as a referral tool by evaluating its performance in predicting 1-year event-free survival from death, heart transplant (HTx), and ventricular assist device (VAD) implantation.

Methods: We retrospectively reviewed the charts of consecutive patients with advanced ambulatory HF with New York Heart Association Class III/IV HF and a left ventricular ejection fraction of ≤40% from 2000 to 2016. Read More

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December 2018
3 Reads

The uptake of adolescent vaccinations through the School Immunisation Program in specialist schools in Victoria, Australia.

Vaccine 2018 Dec 3. Epub 2018 Dec 3.

The Department of Paediatrics, The University of Melbourne, Melbourne, Australia; Department of General Medicine, The Royal Children's Hospital, Melbourne, Australia; Vaccine and Immunisation Research Group, Murdoch Children's Research Institute, Melbourne, Australia; The School of Population Health, The University of Melbourne, Melbourne, Australia.

Background: As part of the National Immunisation Program (NIP) students in Australia receive adolescent immunisations through the School Immunisation Program at 12 to 13 years. For children with disabilities attending specialist schools, no vaccine uptake data is collected at this time point. We aimed to determine uptake of diphtheria-tetanus-pertussis (dTpa) and Human Papillomavirus (HPV) immunisations amongst young people with disabilities in specialist schools in Victoria. Read More

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December 2018

Laparoscopy for blunt abdominal trauma: A Challenging Endeavor.

Scand J Surg 2018 Dec 6:1457496918816927. Epub 2018 Dec 6.

1  Department of Surgery, Dr George Mukhari Academic Hospital, Sefako Makgatho Health Sciences University, Pretoria, South Africa.

Background And Aims:: Laparoscopy in blunt abdominal trauma is challenging because of multiple associated injuries, higher trauma score values and higher morbidity and mortality, as compared with patients with penetrating abdominal trauma. The aim of this study was to investigate the role of laparoscopy in the management of blunt abdominal trauma patients and to highlight related challenges.

Material And Methods:: Over a 4-year period, patients managed laparoscopically for blunt abdominal trauma were retrospectively analyzed. Read More

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December 2018

Wide-area transepithelial sampling with computer-assisted 3-dimensional analysis (WATS) markedly improves detection of esophageal dysplasia and Barrett's esophagus: analysis from a prospective multicenter community-based study.

Dis Esophagus 2018 Dec 12. Epub 2018 Dec 12.

Gastroenterology, New York University Langone Medical Center, New York, NY, USA.

The 4-quadrant forceps biopsy (FB) protocol for identifying Barrett's esophagus (BE) and esophageal dysplasia (ED) suffers from poor sensitivity due to significant sampling error. We investigated the benefit of wide-area transepithelial sampling with 3-dimensional computer-assisted analysis (WATS) used adjunctively to the combination of random and targeted FB in the detection of ED, and as a secondary outcome, BE. In this multicenter prospective trial, community endoscopists at 21 sites utilized WATS as an adjunct to both targeted and random FB in patients undergoing BE screening and surveillance. Read More

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December 2018
3 Reads

Family burden predicts functional outcome in the early course of schizophrenia beyond psychiatric symptoms and baseline functioning.

Schizophr Res 2018 Dec 7;202:328-332. Epub 2018 Jul 7.

UCLA Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, 300 Medical Plaza, Room 2240, Los Angeles, CA 90095, USA; UCLA Department of Psychology, UCLA, USA. Electronic address:

The goal of this study was to determine if family burden experienced by the families of individuals with a recent-onset of schizophrenia is associated with whether the individual is able to work or attend school during the first year of treatment. Forty-one participants with a recent first episode of schizophrenia and their families enrolled in two NIMH-funded protocols through the UCLA Aftercare Research Program completed a measure of family burden at baseline. Amount of work during this time was also recorded. Read More

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December 2018

Occult injuries of the contralateral sacroiliac joint in operatively treated pelvis fractures: incidence, root cause analysis, and proposal of treatment algorithm.

Int Orthop 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopaedics, Denver Health Medical Center, 777 Bannock Street, Denver, CO, 80204, USA.

Purpose: To determine the most common injury patterns, root cause, and the frequency with which unrecognized contralateral posterior ring injury occurs in patients presenting with surgically treated pelvic fractures.

Methods: The medical records of 73 patients presenting to our level I trauma center (52 male and 21 female patients; mean age 41.8 years; range 18-89 years) with surgically treated pelvic ring fractures between January 1, 2016 and January 1, 2018 were reviewed. Read More

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December 2018

Diagnosis of diaphragm injuries using modern 256-slice CT scanners: too early to abandon operative exploration.

Trauma Surg Acute Care Open 2018 26;3(1):e000251. Epub 2018 Nov 26.

Division of Acute Care Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: Missed injury of the diaphragm may result in hernia formation, enteric strangulation, and death. Compounding the problem, diaphragmatic injuries are rare and difficult to diagnose with standard imaging. As such, for patients with high suspicion of injury, operative exploration remains the gold standard for diagnosis. Read More

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November 2018

Diagnostic Errors in Tuberculous Patients: A Multicenter Study from a Developing Country.

J Environ Public Health 2018 13;2018:1975931. Epub 2018 Nov 13.

Department of Statistics, Faculty of Mathematical Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.

Although there is still much to learn about the types of errors committed in health care and why they occur, enough is known today to recognize that a serious concern exists for patients. Tuberculosis (TB) is an infectious disease that is frequently subject to diagnostic errors. Missed or delayed diagnosis of TB can affect patients and community adversely. Read More

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November 2018

Continuous Versus Intermittent Vital Signs Monitoring Using a Wearable, Wireless Patch in Patients Admitted to Surgical Wards: Pilot Cluster Randomized Controlled Trial.

J Med Internet Res 2018 Dec 11;20(12):e10802. Epub 2018 Dec 11.

Leeds Institute of Biomedical & Clinical Sciences, University of Leeds, Leeds, United Kingdom.

Background: Vital signs monitoring is a universal tool for the detection of postoperative complications; however, unwell patients can be missed between traditional observation rounds. New remote monitoring technologies promise to convey the benefits of continuous monitoring to patients in general wards.

Objective: The aim of this pilot study was to evaluate whether continuous remote vital signs monitoring is a practical and acceptable way of monitoring surgical patients and to optimize the delivery of a definitive trial. Read More

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December 2018
1 Read

Overcoming the barriers of teaching physical examination at the bedside: more than just curriculum design.

BMC Med Educ 2018 Dec 11;18(1):302. Epub 2018 Dec 11.

Department of Medicine, The Ottawa Hospital, University of Ottawa and the Ottawa Hospital Research Institute, 501 Smyth Road CPCR L2135, Box 209, Ontario, Ottawa, K1H 8L6, Canada.

Background: Physicians in training must achieve a high degree of proficiency in performing physical examinations and must strive to become experts in the field. Concerns are emerging about physicians' abilities to perform these basic skills, essential for clinical decision making. Learning at the bedside has the potential to support skill acquisition through deliberate practice. Read More

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December 2018
1 Read

Think twice, look twice: Eustachian valve endocarditis due to .

J Cardiol Cases 2013 Feb 11;7(2):e51-e52. Epub 2012 Dec 11.

Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Clinical Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK.

Eustachian valve endocarditis is a rare cause of infective endocarditis. We present the case of a 72-year-old woman in whom this was found after a lengthy search. We then go on to discuss the prevalence and some of the difficulties found in the investigation of this disease. Read More

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February 2013

Too Many Biopsies Performed to Rule Out Hirschsprung's Disease: But It is Worth Doing Them.

Eur J Pediatr Surg 2018 Dec 10. Epub 2018 Dec 10.

Department of Paediatric Surgery, Noah's Ark Children's Hospital for Wales, Cardiff, United Kingdom.

Introduction:  The U.K. National Institute for Health and Clinical Excellence (NICE) specify the following indications for performing rectal biopsy to rule out Hirschsprung's disease (HSD): (1) passage of meconium > 48 hours; (2) constipation since first few weeks of life; (3) chronic abdominal distension with vomiting; (4) family history of HSD; and (5) faltering growth in addition to any other indication. Read More

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December 2018