819 results match your criteria Miscarriages Caused by Blood Coagulation Protein or Platelet Deficits

Ischemic Stroke in a SARS-CoV-2-Positive Octagenarian Without Cardiovascular Risk Factors: A Case Report.

Josef Finsterer

Cureus 2022 Mar 30;14(3):e23654. Epub 2022 Mar 30.

Neurology, Neurology and Neurophysiology Center, Vienna, AUT.

Ischemic and hemorrhagic strokes are increasingly recognized as complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. The absence of cardiovascular risk factors in SARS-CoV-2-infected patients who suffer a stroke supports a causal relationship as shown in the following report. The patient is an 86-year-old female who developed a mild, brachio-facial, right-sided hemi-symptomatic during a mild infection with SARS-CoV-2. Read More

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Distanct ischemic postconditioning in acute mild to moderate ischemic stroke: A randomized clinical study.

J Clin Neurosci 2022 Jun 13;100:89-93. Epub 2022 Apr 13.

Department of Neurology, the First Affiliated Hospital of Dalian Medical University, Dalian, PR China. Electronic address:

Objective: Distant ischemic postconditioning (DIPC) has been confirmed to have a neuroprotective effect in animal models of ischemia. However, there are only a few studies on its efficacy and safety in clinical applications.

Method: We divided 86 patients with acute non-cardiogenic mild to moderate cerebral infarction into DIPC and control groups. Read More

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Gestational and Lactational Iron Deficiency Anemia Impairs Myelination and the Neurovascular Unit in Infant Rats.

Mol Neurobiol 2022 Apr 6. Epub 2022 Apr 6.

Neurobiología Celular y Molecular, Instituto de Investigaciones Biológicas Clemente Estable (IIBCE), 3318, Italia Av., 11600, Montevideo, Uruguay.

Iron deficiency anemia is a prevalent health problem among pregnant women and infants, particularly in the developing countries that causes brain development deficits and poor cognitive outcomes. Since tissue iron depletion may impair myelination and trigger cellular hypoxic signaling affecting blood vessels, we studied myelination and the neurovascular unit (NVU) in infant rats born to mothers fed with an iron deficient (ID) or control diet from embryonic day 5 till weaning. Blood samples and brains of rat pups at postnatal day (PND) 14 and 30 were analyzed. Read More

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Effect of tirofiban in treating patients with progressive ischemic stroke.

Eur Rev Med Pharmacol Sci 2022 Mar;26(6):2098-2105

Department of Neurology, Clinical Medical College of Dali University, Dali, China.

Objective: Our aim is to investigate the efficacy and safety of tirofiban in the treatment of patients experiencing progressive ischemic stroke (PIS).

Patients And Methods: A retrospective analysis was performed on the clinical data of 150 patients with ischemic stroke admitted to our hospital from May 2018 to December 2019. All the patients were divided into two groups according to different treatment methods. Read More

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J147 Reduces tPA-Induced Brain Hemorrhage in Acute Experimental Stroke in Rats.

Front Neurol 2022 2;13:821082. Epub 2022 Mar 2.

Department of Neurosurgery and Neuroscience Institute, Penn State Hershey Medical Center, Hershey, PA, United States.

Background And Purpose: J147, a novel neurotrophic compound, was originally developed to treat aging-associated neurological diseases. Based on the broad spectrum of cytoprotective effects exhibited by this compound, we investigated whether J147 has cerebroprotection for acute ischemic stroke and whether it can enhance the effectiveness of thrombolytic therapy with tissue plasminogen activator (tPA).

Methods: Rats were subjected to transient occlusion of the middle cerebral artery (tMCAO) by insertion of an intraluminal suture or embolic middle cerebral artery occlusion (eMCAO), and treated intravenously with J147 alone or in combination with tPA. Read More

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Vaccine-induced thrombotic thrombocytopenia (VITT): first report from India.

Thromb J 2022 Mar 4;20(1):11. Epub 2022 Mar 4.

Clinical Haematology & Bone Marrow Transplantation, Believers Church Medical College Hospital, Thiruvalla, Kerala, 689103, India.

Background: Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare but devastating adverse event following adenoviral vector-based vaccinations for COVID-19, resulting in thrombosis, especially of the cerebral and splanchnic vasculature. Despite the progress in laboratory techniques for early diagnosis, VITT remains a clinical diagnosis supplemented by coagulation studies. We report on VITT for the first time from India. Read More

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Transfusion Ratios and Deficits in Injured Children With Life-Threatening Bleeding.

Pediatr Crit Care Med 2022 04 28;23(4):235-244. Epub 2022 Feb 28.

Department of Surgery, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.

Objectives: To assess the impact of plasma and platelet ratios and deficits in injured children with life-threatening bleeding.

Design: Secondary analysis of the MAssive Transfusion epidemiology and outcomes In Children study dataset, a prospective observational study of children with life-threatening bleeding events.

Setting: Twenty-four childrens hospitals in the United States, Canada, and Italy. Read More

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Downregulation of the schizophrenia risk-gene Dgcr2 alters early microcircuit development in the mouse medial prefrontal cortex.

Int J Dev Neurosci 2022 May 11;82(3):277-285. Epub 2022 Mar 11.

Department of Psychiatry, University of Geneva Medical School, Geneva, Switzerland.

Alterations in the generation, migration and integration of different subtypes of neurons in the medial prefrontal cortex (mPFC) microcircuit could play an important role in vulnerability to schizophrenia. Using in vivo cell-type specific manipulation of pyramidal neurons (PNs) progenitors, we aim to investigate the role of the schizophrenia risk-gene DiGeorge Critical Region 2 (Dgcr2) on cortical circuit formation in the mPFC of developing mice. This report describes how Dgcr2 knock down in upper-layer PNs impacts the functional maturation of PNs and interneurons (INs) in the mPFC. Read More

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The Effect of TGF-β1 Reduced Functionality on the Expression of Selected Synaptic Proteins and Electrophysiological Parameters: Implications of Changes Observed in Acute Hepatic Encephalopathy.

Int J Mol Sci 2022 Jan 19;23(3). Epub 2022 Jan 19.

Department of Neurotoxicology, Mossakowski Medical Research Institute, Polish Academy of Sciences, 5 Pawińskiego Str., 02-106 Warsaw, Poland.

Decreased platelet count represents a feature of acute liver failure (ALF) pathogenesis. Platelets are the reservoir of transforming growth factor 1 (TGF-β1), a multipotent cytokine involved in the maintenance of, i.a. Read More

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January 2022

'Crescendo transient ischemic attack'-an uncommon presentation of a very common disease: a case report on capsular warning syndrome.

Oxf Med Case Reports 2022 Jan 24;2022(1):omab129. Epub 2022 Jan 24.

Department of Internal Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia.

Capsular warning syndrome is a rare presentation of transient ischaemic attack, which described as recurrent episodes of motor and/or sensory deficits which typically sparring the cortical function. It has a significant risk to progress into a massive stroke with permanent disability, thus important to be recognise early. Here, we report a middle-age gentleman with no known medical illness presented with eight episodes of transient ischaemic attack within the span of 24 h. Read More

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January 2022

Post-stroke treatment with K-134, a phosphodiesterase 3 inhibitor, improves stroke outcomes in the stroke-prone spontaneously hypertensive rat model-A comparative evaluation of antiplatelet drugs.

J Pharmacol Sci 2022 Feb 7;148(2):229-237. Epub 2021 Dec 7.

Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba, Ibaraki, Japan; AIST-University of Tsukuba Open Innovation Laboratory for Food and Medicinal Resource Engineering (FoodMed-OIL), University of Tsukuba, Tsukuba, Japan; Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.

Post-stroke antiplatelet therapy has been proved to reduce the risk of recurrent stroke; however, it may also increase the incidence of intracranial hemorrhage that could offset any benefits. Therefore, the balance between the benefits and risks of antiplatelet drugs is a critical issue to consider. In the present study, we have compared the effects of post-stroke administration of antiplatelet agents on functional outcomes in the stroke-prone spontaneously hypertensive rat (SHRSP), an established animal model that mimics human lacunar stroke and cerebral small vessel disease. Read More

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February 2022

Recycling Apparent Waste Into Biologicals: The Case of Umbilical Cord Blood in Italy and Spain.

Front Cell Dev Biol 2021 4;9:812038. Epub 2022 Jan 4.

Centro Nazionale Sangue, Rome, Italy.

Most public cord blood banking programs are currently facing financial difficulties due to a progressive decline in the number of cord blood transplants performed worldwide and to a high discard rate of the donated units caused by progressively increasing thresholds of the stem cell dose required to perform safe and effective hemopoietic cord blood transplants. Recycling a proportion of unused cord blood units to prepare novel cord blood components obtained with minimal manipulation (platelets, plasma, red blood cells) and to develop more technologically complex products regulated in the US as Cellular and Gene Therapy Products and in Europe as Advanced Therapy Medicinal Products [e.g. Read More

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January 2022

Dynamic changes of CSF sPDGFRβ during ageing and AD progression and associations with CSF ATN biomarkers.

Mol Neurodegener 2022 01 15;17(1). Epub 2022 Jan 15.

Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.

Background: Loss of brain capillary pericyte is involved in the pathologies and cognitive deficits in Alzheimer's disease (AD). The role of pericyte in early stage of AD pathogenesis remains unclear.

Methods: We investigated the dynamic changes of soluble platelet-derived growth factor receptor β (sPDGFRβ) in cerebrospinal fluid (CSF), a marker of brain pericyte injury, in transition from normal ageing to early AD in a cognitively unimpaired population aged 20 to 90 years. Read More

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January 2022

Extension of the Human Fibrinogen Database with Detailed Clinical Information-The αC-Connector Segment.

Int J Mol Sci 2021 Dec 23;23(1). Epub 2021 Dec 23.

Department of Biochemistry, Institute of Hematology and Blood Transfusion, U Nemocnice 1, 12800 Prague, Czech Republic.

Fibrinogen, an abundant plasma glycoprotein, is involved in the final stage of blood coagulation. Decreased fibrinogen levels, which may be caused by mutations, are manifested mainly in bleeding and thrombotic disorders. Clinically relevant mutations of fibrinogen are listed in the Human Fibrinogen Database. Read More

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December 2021

Clinical and Laboratory Diagnostic Features of Kyasanur Forest Disease: A Study From Wayanad, South India.

Cureus 2021 Dec 6;13(12):e20194. Epub 2021 Dec 6.

Department of Health Services, Health Services, Government of Kerala, Kerala, IND.

Background Kyasanur forest disease (KFD), also known as monkey fever, was first recognized in the Shimoga district of Karnataka, India, in 1957. This study was conceived to address the paucity of medical literature on KFD, to describe the clinical and laboratory features of real-time reverse-transcriptase-polymerase chain reaction (rRT-PCR) confirmed cases of KFD, and to detect any change in the clinical picture and presentation of the disease over the last 30 years. Aim The study sought to document the clinical and laboratory features of Kyasanur forest disease (KFD), a tick-borne arboviral disease, now emerging in many parts of southern India. Read More

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December 2021

Phospholipid Profiles for Phenotypic Characterization of Adipose-Derived Multipotent Mesenchymal Stromal Cells.

Front Cell Dev Biol 2021 1;9:784405. Epub 2021 Dec 1.

Institute for Medical Physics and Biophysics, Faculty of Medicine, University of Leipzig, Leipzig, Germany.

Multipotent mesenchymal stromal cells (MSC) have emerged as therapeutic tools for a wide range of pathological conditions. Yet, the still existing deficits regarding MSC phenotype characterization and the resulting heterogeneity of MSC used in different preclinical and clinical studies hamper the translational success. In search for novel MSC characterization approaches to complement the traditional trilineage differentiation and immunophenotyping assays reliably across species and culture conditions, this study explored the applicability of lipid phenotyping for MSC characterization and discrimination. Read More

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December 2021

Lentiviral-Induced Spinal Cord Gliomas in Rat Model.

Int J Mol Sci 2021 Nov 30;22(23). Epub 2021 Nov 30.

Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA.

Intramedullary spinal cord tumors are a rare and understudied cancer with poor treatment options and prognosis. Our prior study used a combination of PDGF-B, HRAS, and p53 knockdown to induce the development of high-grade glioma in the spinal cords of minipigs. In this study, we evaluate the ability of each vector alone and combinations of vectors to produce high-grade spinal cord gliomas. Read More

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November 2021

Novel optimized drug delivery systems for enhancing spinal cord injury repair in rats.

Drug Deliv 2021 Dec;28(1):2548-2561

Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou City, PR China.

Effective and accurate delivery of drugs to tissue with spinal cord injury (SCI) is the key to rehabilitating neurological deficits. Sustained-release microspheres (MS) have excellent degradability and can aid in the long-term release of drugs. However, the burst release phenomenon can cause unexpected side effects. Read More

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December 2021

Reactive Thrombocytosis Related Cerebral Venous Thrombosis: A Rare Complication of Untreated Iron Deficiency Anemia.

Cureus 2021 Oct 26;13(10):e19064. Epub 2021 Oct 26.

Neurology, University of Connecticut, Hartford Hospital, Hartford, USA.

Thrombocytosis can be either primary or secondary, and it can cause venous pro-thrombotic states like cerebral venous thrombosis. Untreated iron deficiency anemia is postulated to cause reactive (secondary) thrombocytosis due to the proliferation of common progenitor cells. Here we present a case of a middle-aged woman with polycystic ovary syndrome and episodes of menorrhagia. Read More

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October 2021

Analysis of Factors Affecting Post-Stroke Fatigue: An Observational, Cross-Sectional, Retrospective Chart Review Study.

Healthcare (Basel) 2021 Nov 19;9(11). Epub 2021 Nov 19.

Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.

Post-stroke fatigue (PSF) is one of the most common emotional and mood disorders in stroke survivors. Several studies have suggested associations between PSF and various factors. However, they describe conflicting results. Read More

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November 2021

Ischemic Stroke as a Manifestation of Cholesterol Embolization Syndrome Following Percutaneous Coronary Intervention.

Kathmandu Univ Med J (KUMJ) 2021 Jan.-Mar;19(73):143-145

Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.

Cholesterol embolization syndrome (CES) is one of the major, yet underdiagnosed cause of morbidity and mortality following invasive coronary interventions. The major risk factors are elderly, male, atherosclerotic disease, anticoagulation and femoral access route. This multisystem disease affects skin, kidney, brain, eye and gastrointestinal tract. Read More

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November 2021

Inhibition of GPR17 with cangrelor improves cognitive impairment and synaptic deficits induced by Aβ through Nrf2/HO-1 and NF-κB signaling pathway in mice.

Int Immunopharmacol 2021 Dec 12;101(Pt B):108335. Epub 2021 Nov 12.

School of Pharmacy, Anhui Medical University, The Key Laboratory of Major Autoimmune Diseases of Anhui Province, Hefei 230032, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Anhui Medical University, Ministry of Education, Hefei 230032, China. Electronic address:

The accumulation of amyloid beta (Aβ) in the brain is thought to be associated with cognitive deficits in Alzheimer's disease (AD). However, current methods to combat Aβ neurotoxicity are still lacking. G protein-coupled receptor 17 (GPR17) has become a target for treating inflammation in brain diseases, but it is unclear whether it has a role in AD. Read More

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December 2021

Early argatroban and antiplatelet combination therapy in acute non-lacunar single subcortical infarct associated with mild intracranial atherosclerosis.

BMC Neurol 2021 Nov 10;21(1):440. Epub 2021 Nov 10.

Department of Neurology, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, No.70, Heping road, Huancui District, Weihai City, 264200, Shandong Province, China.

Background: Patients with acute non-lacunar single subcortical infarct (SSI) associated with mild intracranial atherosclerosis (ICAS) have a relatively high incidence of early neurological deterioration (END), resulting in unfavorable functional outcomes. Whether the early administration of argatroban and aspirin or clopidogrel within 6-12 h after symptom onset is effective and safe in these patients is unknown.

Methods: A review of the stroke database of Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University and Qingdao Center Hospital, Qingdao University Medical College in China was undertaken from May 2017 to January 2020 to identify all patients with non-lacunar SSI caused by ICAS within 6-12 h of symptom onset based on MRI screening. Read More

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November 2021

GAS6/Axl Signaling Modulates Blood-Brain Barrier Function Following Intravenous Thrombolysis in Acute Ischemic Stroke.

Front Immunol 2021 18;12:742359. Epub 2021 Oct 18.

Stroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.

Background And Purpose: Recent studies have shown that several proteins, including Axl, are related to hemorrhagic transformation (HT) following intravenous thrombolysis by affecting blood-brain barrier (BBB) function. However, the effects of these proteins on BBB function have been studied primarily in animal models. In this study, we aimed to identify serum protein markers that predict HT following intravenous thrombolysis in patients with acute ischemic stroke (AIS) and verify whether these serum proteins regulate BBB function and HT in animal stroke models. Read More

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December 2021

Ischemic Stroke in Patients with Cancer: a Retrospective Cross-Sectional Study.

J Crit Care Med (Targu Mures) 2021 Jan 29;7(1):54-61. Epub 2021 Jan 29.

George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures Targu Mures, Romania.

Introduction: An increasing trend of cancer associated stroke has been noticed in the past decade.

Objectives: To evaluate the risk factors and the incidence of neoplasia in stroke patients.

Material And Method: A retrospective, observational study was undertaken on 249 patients with stroke and active cancer (SAC) and 1563 patients with stroke without cancer (SWC). Read More

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January 2021

Cerebral venous sinus thrombosis after ChAdOx1 vaccination: the first case of definite thrombosis with thrombocytopenia syndrome from India.

BMJ Case Rep 2021 Oct 27;14(10). Epub 2021 Oct 27.

Endocrinology, Salford Royal NHS Foundation Trust, Salford, UK

Cerebral venous sinus thrombosis (CVST) following novel coronavirus-2019 (nCoV-19) vaccination is a rare adverse effect. We report the first case of CVST associated with ChAdOx1 vaccination, with positive anti-platelet factor 4 (PF4) antibodies, from India. A 44-year-old woman developed a thunderclap headache 4 days after the first dose of the adenoviral vector vaccine ChAdOx1 (Covishield). Read More

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October 2021

Inherited and acquired thrombophilia in women of Indian ethnicity with recurrent pregnancy loss: An observational study from North India.

Indian J Pathol Microbiol 2021 Oct-Dec;64(4):741-745

Department of Hematology, AIIMS, New Delhi, India.

Objectives: The spectrum of thrombophilia in women with recurrent pregnancy loss (RPL) is different in Indian ethnicity as reported by few studies. We aimed to study the prevalence of thrombophilia in RPL patients referred to hematology department of a tertiary centre.

Material And Methods: This is an observational study of 112 RPL patients with no apparent cause after extensive workup for non-hematological causes. Read More

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February 2022

[Intracerebral hemorrhage under platelet inhibition and oral anticoagulation in patients with cerebral amyloid angiopathy].

Nervenarzt 2021 Oct 15. Epub 2021 Oct 15.

Institut und Poliklinik für diagnostische und interventionelle Neuroradiologie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.

Oral anticoagulation in patients with cerebral amyloid angiopathy is a therapeutic challenge. The association of cerebral amyloid angiopathy with intracerebral hemorrhage, a high mortality of intracerebral hemorrhage especially under oral anticoagulation and the high risk of recurrent bleeding require a multidisciplinary approach and a thorough risk-benefit analysis. Vitamin K antagonists increase the risk of intracerebral bleeding and the accompanying mortality by 60% and should be avoided if possible or reserved for special clinical situations (e. Read More

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October 2021

An Unusual Cause of Internal Carotid Artery Dissection: Mobile Phone Misuse.

Ann Vasc Surg 2022 Feb 10;79:437.e1-437.e3. Epub 2021 Oct 10.

Department of Neurology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

The use of mobile phones has become an indispensable part of our lives, especially due to widespread use of the internet. We report the case of a 38-year-old male patient who developed internal carotid artery dissection after talking on the phone between her left shoulder and ear by laterally flexing the neck for 20 minutes. In addition to many positive effects of technology that facilitate the daily life, the development of neurological deficits may be observed with widespread use of mobile phones. Read More

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February 2022

Protective multi‑target effects of DL‑3‑n‑butylphthalide combined with 3‑methyl‑1‑phenyl‑2‑pyrazolin‑5‑one in mice with ischemic stroke.

Mol Med Rep 2021 Dec 13;24(6). Epub 2021 Oct 13.

Department of Basic Medicine, Jitang College of North China University of Science and Technology, Tangshan, Hebei 063210, P.R. China.

DL‑3‑n‑butylphthalide (NBP) and 3‑methyl‑1- phenyl‑2‑pyrazolin‑5‑one (edaravone) are acknowledged neuroprotective agents that protect against ischemic stroke. However, the underlying mechanisms of a combination therapy with NBP and edaravone have not yet been fully clarified. The aim of the present study was to explore whether the co‑administration of NBP and edaravone had multi‑target protective effects on the neurovascular unit (NVU) of mice affected by ischemic stroke. Read More

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December 2021