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Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, NY 10021.

Background: Age-related decline in reproductive potential is mainly due to the increased incidence of aneuploidy. Furthermore, two recent studies have shown that euploid embryos of older women may have a lower implantation potential compared to those of younger women, suggesting that aging might compromise embryos beyond their ploidy status. However, the inherent limitations of these studies preclude solid conclusions. Read More

J Assoc Genet Technol 2018 ;44(4):137-140

Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT.

Objectives: While the complete form of trisomy 22 is seemingly incompatible with life, the mosaic form is a rare syndrome associated with developmental delays, intellectual disability, and dysmorphic features. Due in part to the difficulty of analyzing chromosomal mosaicism, many instances either go undiagnosed or have their diagnosis delayed. We report a case of mosaic trisomy 22 in a diamnionic-dichorionic twin with marked growth discordance and intra-uterine growth restriction, diagnosed in a 2-year-old with developmental delays, sensorineural hearing loss, cardiac and gastrointestinal abnormalities, and osteopenia of prematurity. Read More

Cell J 2019 Apr 18;21(1):92-98. Epub 2018 Nov 18.

Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic Address:

Objective: Mesenchymal stem cells (MSCs), due to their immunomodulatory functions, are an ideal candidate for the treatment of immune-related diseases. Recurrent spontaneous abortion (RSA) is one of the most common complications of pregnancy which in many cases is related to the immune system disorders. Our previous study has shown that the abortion rate was decreased following the syngeneic MSCs therapy in abortion-prone mice. Read More

Biochem Biophys Res Commun 2018 Nov 28. Epub 2018 Nov 28.

Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. Electronic address:

Problem: Recurrent spontaneous abortion (RSA) is associated with immune imbalance at the maternal-fetal interface. Decidual immune cells and cytokines expressed at this interface regulate the response of the maternal immune system to the fetus. However, the populations and cytokine expression levels of these lymphocytes in miscarriage with normal and abnormal chromosome karyotypes remain unclear. Read More

Fertil Steril 2018 Dec;110(7):1408-1409

Department of Obstetrics and Gynecology, BC Women's Hospital and Health Centre, University of British Columbia, Vancouver, British Columbia, Canada.

Objective: To introduce and demonstrate an approach to the hysteroscopic removal of retained intrauterine devices (IUDs) in pregnancy. Pregnancy risks associated with retained IUDs are also discussed, specifically spontaneous abortion and preterm labor.

Design: A step-by-step explanation of the procedure with surgical video footage. Read More

Vaccine 2018 Nov 28. Epub 2018 Nov 28.

Danish Cancer Society Research Center, Virus, Lifestyle and Genes, Strandboulevarden 49, DK-2100 Copenhagen, Denmark; Department of Gynecology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic address:

Background: Few studies have studied the association between unintended human papillomavirus (HPV) vaccination and adverse pregnancy outcomes. This study set out to determine the association between HPV vaccination during pregnancy and subsequent risk of spontaneous abortion, stillbirth, and one-year infant mortality.

Methods: Population-based study including all pregnancies in Denmark (October 2006-December 2014) among women born 1975-1992. Read More

Epidemiol Infect 2018 Dec 3:1-7. Epub 2018 Dec 3.

Section of Epidemiology, Department of Public Health,University of Copenhagen,Copenhagen,Denmark.

It has been reported that foetal death follows a seasonal pattern. Influenza virus infection has been postulated as one possible contributor to this seasonal variation. This ecological study explored the temporal association between the influenza activity and the frequency of foetal death. Read More

Hum Fertil (Camb) 2018 Dec 2:1-11. Epub 2018 Dec 2.

a Korea University College of Medicine , Seoul , Korea.

Tumour necrosis factor alpha (TNF-α) concentration is associated with recurrent pregnancy loss (RPL). Moreover, TNF-α promoter polymorphisms affect cellular TNF-α concentrations. Although several studies on TNF-α polymorphisms have been reported, these studies only define specific loci and result in conflicting conclusions. Read More

J Patient Saf 2018 Dec 3. Epub 2018 Dec 3.

Center for Applied Studies in Health Economics, Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania.

Objective: The aim of the study was to examine whether miscarriage treatment-related morbidities and adverse events vary across facility types.

Methods: A retrospective cohort study compared miscarriage treatment-related morbidities and adverse events across hospitals, ambulatory surgery centers (ASCs), and office-based settings. Data on women who had miscarriage treatment between 2011 and 2014 and were continuously enrolled in their insurance plan for at least 1 year before and at least 6 weeks after treatment were obtained from a large national private insurance claims database. Read More

Eurasian J Med 2018 Oct;50(3):187-192

Department of Public Health, Atatürk University, Erzurum, Turkey.

Objective: Fertility preferences and status are important parameters involved in reproductive health. The aim of the present study was to define some characteristics of the fertility preferences of women aged 15-49 years in our region.

Materials And Methods: This cross-sectional study was conducted between 2013 and 2015. Read More

Thorax 2018 Dec 4. Epub 2018 Dec 4.

Centre for Fertility and Health (CeFH), Norwegian Institute of Public Health, Oslo, Norway.

Background: It remains unclear what underlies the greater risk of asthma reported among children conceived by assisted reproductive technologies (ART).

Objective: Our aim was to clarify the role of parental subfertility and unmeasured confounding on the association between ART and childhood asthma, and to examine the possibility for common mechanisms underlying parental subfertility and miscarriages influencing asthma pathogenesis.

Methods: We used data from national Norwegian health registries (n=474 402) and the Norwegian Mother and Child Cohort Study (MoBa) (n=75 797). Read More

Thorax 2018 Dec 4. Epub 2018 Dec 4.

BMC Womens Health 2018 Dec 4;18(1):196. Epub 2018 Dec 4.

Zealand University Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: Lifestyle, in particular obesity and smoking has significant impacts on fertility and an important focus for the treatment of reproductive failures is the optimisation of periconceptional lifestyle behaviours. The preimplantation intrauterine environment within the uterus is also key for embryo development and early programming. Although the benefits a healthy periconceptional lifestyle are well described, there remains a paucity of data demonstrating the efficacy of interventions designed to optimise preconceptional lifestyle behaviours and choices. Read More

Case Rep Infect Dis 2018 28;2018:2318539. Epub 2018 Oct 28.

Associate Residency Program Director, Newark Beth Medical Center, Department of Medicine, Newark, NJ, USA.

This is a case of a 38-year-old female with latent TB complicated by disseminated peritoneal TB with associated spontaneous abortion, who was initially thought to have an ovarian neoplasm, prompting extensive workup. Laparoscopy with biopsy later confirmed the patient's condition; she was initiated on the appropriate therapy and had a full recovery. Read More

Hum Reprod 2018 Nov 30. Epub 2018 Nov 30.

Boston IVF, Waltham, MA, USA.

Study Question: What is the treatment path and cumulative live birth (CLB) rate from a single oocyte retrieval of patients who intend to pursue PGT-A at the start of an IVF cycle compared to matched controls?

Summary Answer: The choice of PGT-A at the start of the first IVF cycle decreases the CLB per oocyte retrieval for patients <38 years of age, however patients ≥38 years of age benefit significantly per embryo transfer (ET) when live birth (LB) is evaluated.

What Is Known Already: PGT-A has been shown to reduce the practice of transferring multiple embryos and to confer a higher live birth rate per transfer.

Study Design, Size, Duration: This is a retrospective cohort study from December 2014 to September 2016, involving 600 patients: those intending PGT-A for their first IVF cycle (N = 300) and their matched controls. Read More

BMJ Open 2018 Nov 28;8(11):e024175. Epub 2018 Nov 28.

Public Health Interventions Research Group, Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.

Introduction: Several bacterial sexually transmitted and genital mycoplasma infections during pregnancy have been associated with poor pregnancy and perinatal outcomes. Comprehensive and systematic information about associations between sexually transmitted infections (STI) and genital infections in pregnancy and adverse perinatal outcomes is needed to improve understanding about the evidence for causal associations between these infections and adverse pregnancy and neonatal outcomes. Our primary objective is to systematically review the literature about associations between: (1) in pregnancy and preterm birth; (2) in pregnancy and preterm birth; (3) and/or in pregnancy and preterm birth. Read More

Int J Cancer 2018 Nov 29. Epub 2018 Nov 29.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.

The constitutional t(11;22)(q23;q11) translocation is the only recurrent non-Robertsonian translocation known in humans. Carriers are phenotypically normal and are usually referred for cytogenetic testing because of multiple miscarriages, infertility, or having aneuploidy in offspring. A breast cancer predisposition has been suggested, but previous studies have been small and had methodological shortcomings. Read More

Hum Reprod 2018 Nov 29. Epub 2018 Nov 29.

CHU de Bordeaux, Endocrinology and Metabolism, Reproductive Medicine Unit, Bordeaux, France.

Study Question: Does endometrial scratch in women undergoing a first or second IVF/ICSI attempt improve the clinical pregnancy rate (CPR)?

Summary Answer: Endometrial scratch (ES) in women undergoing their first or second IVF/ICSI attempt does not enhance the CPR under the technical conditions of our study.

What Is Known Already: Several studies have suggested that physical scratch of the endometrium before an IVF attempt could improve embryo implantation.

Study Design, Size, Duration: This was a randomized controlled multi-center, two-arm, parallel trial. Read More

Biol Reprod 2018 Nov 28. Epub 2018 Nov 28.

Department of Obstetrics and Gynecology, the First affiliated hospital, Chongqing Medical University, Chongqing, China.

Recurrent spontaneous abortion (RSA) is associated with abnormal maternal tolerance to the semi-allogenic fetus, wherein the Th17/Treg axis plays a crucial role. Adiponectin (APN) is an adipocytokine that is shown to be a novel negative T-cell regulator and induce immune tolerance. The CBA/J × DBA/2 mating was used as an abortion-prone model to investigate whether the addition of recombinant adiponectin (rAPN) improves the pregnancy outcome. Read More

Biotechnol J 2018 Nov 28:e1800238. Epub 2018 Nov 28.

Biopharming Research Unit, Department of Molecular and Cell Biology, University of Cape Town, Private Bag X3, Rondebosch 7700, South Africa.

Rift valley fever virus (RVFV) is an emerging mosquito borne virus and haemorrhagic fever agent, which causes abortion storms in farmed small ruminants and potentially causes miscarriages in humans. Although live-attenuated vaccines are available for animals, they can only be used in endemic areas and there are currently no commercially available vaccines for humans. Here we describe the production of chimaeric RVFV virus-like particles transiently expressed in Nicotiana benthamiana by Agrobacterium tumefaciens-mediated gene transfer. Read More

An Bras Dermatol 2018 Nov/Dec;93(6):874-877

Department of Pathology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Autoimmune progesterone dermatitis is an uncommon, poorly recognized and under-diagnosed catamenial dermatosis associated with hypersensitivity reactions to progestagens. Most cases manifest as urticaria, eczema or erythema multiforme-like. A 26-year-old woman developed violaceous plaques on the groin and abdomen, 4 days after a spontaneous abortion resolved with uterine curettage. Read More

Endocrinol Diabetes Metab Case Rep 2018 Nov 22;2018. Epub 2018 Nov 22.

Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

Addison's disease (AD) is the most common endocrine manifestation of antiphospholipid syndrome (APS), but it remains a very rare complication of the syndrome. It is caused by adrenal venous thrombosis and consequent hemorrhagic infarction or by spontaneous (without thrombosis) adrenal hemorrhage, usually occurring after surgery or anticoagulant therapy. We present a clinical case of a 36-year-old female patient with a previous diagnosis of APS. Read More

Cochrane Database Syst Rev 2018 Nov 14;11:CD011444. Epub 2018 Nov 14.

ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.

Background: The World Health Organization recommends intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine for malaria for all women who live in moderate to high malaria transmission areas in Africa. However, parasite resistance to sulfadoxine-pyrimethamine has been increasing steadily in some areas of the region. Moreover, HIV-infected women on cotrimoxazole prophylaxis cannot receive sulfadoxine-pyrimethamine because of potential drug interactions. Read More

BMC Pregnancy Childbirth 2018 Nov 26;18(1):458. Epub 2018 Nov 26.

Department of Obstetrics and Gynaecology, University of Zimbabwe College of Health Sciences, Central Hospital, P O Box ST 14, Southerton, Harare, Zimbabwe.

Background: Maternal 'near miss' can be a proxy for maternal death and it describes women who nearly died due to obstetric complications. It measures life threatening pregnancy related complications and allows the assessment of the quality of obstetric care.

Methods: A prospective descriptive study was carried out from October 1 2016 to 31 December 2016, using the WHO criteria for maternal 'near miss' at the two tertiary public hospitals which receive referrals of all obstetric complications in Harare city, Zimbabwe. Read More

BMC Pregnancy Childbirth 2018 Nov 26;18(1):460. Epub 2018 Nov 26.

Division of Women's and Children's Anesthesia, Department of Anesthesiology, Chi Mei Medical Center, 901 Zhonghua Road, Yongkang District, Tainan City, 710, Taiwan.

Background: Whether nonobstetric surgery during gestation is associated with a higher risk of spontaneous abortion or adverse delivery outcomes is still unclear.

Methods: We performed a retrospective case-control study using a Longitudinal Health Insurance Database (LHID 2000) containing claim-data of 1 million randomly selected beneficiaries. We compared the incidences and estimated the adjusted odds ratios (aOR) with 95% confidence interval (95% CI) for spontaneous abortion, adverse delivery outcomes, cesarean delivery, and prolonged hospital stay to determine the risk of adverse outcomes in women who had nonobstetric surgery during gestation as compared to those who did not have any surgery during gestation. Read More

Environ Int 2018 Nov 22. Epub 2018 Nov 22.

Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, PR China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China.

Background: The effect of maternal copper (Cu) level on the risk of spontaneous preterm birth (SPB) remains debate. Therefore, we conducted a prospective nested case-control study in Shanxi Province to investigate the relationship between maternal serum Cu concentration and SPB risk, as well as the potential mediation effect of lipid metabolism.

Method: From an overall cohort of 4229 women, 147 women affected by SPB at 20-36 gestational weeks (cases) and 381 women who delivered at ≥37 gestational weeks (controls) were included in our nested case-control study. Read More

Acta Obstet Gynecol Scand 2018 Nov 25. Epub 2018 Nov 25.

Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark.

Introduction: Monoamniotic twin pregnancies are high-risk pregnancies, and management by inpatient or frequent outpatient care is recommended. We report the outcomes of a national cohort of monoamniotic twin pregnancies managed primarily as outpatients MATERIAL AND METHODS: We analyzed prospectively recorded data from the Danish Fetal Medicine Database, local databases, and medical records of all monoamniotic twin pregnancies diagnosed at the first trimester scan or later, and managed at the six major fetal medicine centers in Denmark over a 10 year period RESULTS: Sixty-one monoamniotic twin pregnancies were included. Thirteen pregnancies were terminated early. Read More

BMC Pregnancy Childbirth 2018 Nov 23;18(1):456. Epub 2018 Nov 23.

Pediatric Gynecology, Department. Gynecology and Obstetrics, University Hospital of Erlangen, Erlangen, Germany.

Background: The most common form of congenital adrenal hyperplasia is 21-hydroxylase deficiency (CAH). Both men and women with classic CAH have lower fertility rates than the general population, and an increased rate of miscarriages has been reported in affected women. There are no data on the incidence rate of miscarriages in families with an offspring that have classic CAH. Read More

Eur Rev Med Pharmacol Sci 2018 Nov;22(21):7105-7112

Department of Obstetrics and Gynecology, Hanchuan People's Hospital of Hubei Province, Hanchuan, China.

Objective: The aim of this study was to investigate the role of long non-coding RNA (lncRNA) TCL6 in early abortion and to explore its underlying mechanism.

Patients And Methods: The expression levels of lncRNA-TCL6 and epidermal growth factor receptor (EGFR) in placental tissues of normal pregnancy, threatened abortion pregnancy, spontaneous abortion pregnancy, and induced abortion pregnancy were detected by quantitative Real-Time Polymerase Chain Reaction (qRT-PCR), respectively. Trophoblast cells were transfected with siRNA to knock-down lncRNA-TCL6. Read More

Soc Sci Med 2018 Sep 21. Epub 2018 Sep 21.

Department of Anthropology, University of Amsterdam, Nieuwe Achtergracht 166, PO Box 15508, 1001 NA Amsterdam, the Netherlands. Electronic address: https://twitter.com/BregjedeKok.

This paper explores loss in childbearing in Malawi (miscarriages, perinatal deaths and maternal mortality) as a lens to understand accountability and health system functioning. In low-income countries, maternal and perinatal mortality reflects poor health system functioning, to be improved in part through accountability. Understanding how accountability plays out on the ground requires examination of the existing, 'organic' accountability relationships and mechanisms. Read More

Prev Vet Med 2018 Dec 1;161:127-133. Epub 2018 Nov 1.

University of Milan, Department of Veterinary Medicine, Via dell'Università 6, 26900, Lodi, Italy. Electronic address:

A program for controlling bovine neosporosis based only on the use of beef semen, without culling seropositive animals, was evaluated in a closed dairy cattle herd over a 5-year period (2013-2017). The program was based on individual and periodic serological screenings to identify seropositive breeders. Seropositive cows were inseminated with beef-breed semen, thus excluding their descendants from the remount in order to prevent the vertical transmission of the disease. Read More

Cytogenet Genome Res 2018 Nov 23. Epub 2018 Nov 23.

We report a case of familial small supernumerary marker chromosome 15 in a phenotypically normal female with 4 recurrent spontaneous abortions and a healthy child. The initial karyotype showed a small, bisatellited, apparently metacentric marker chromosome, 47,XX,+idic(15)(q11.1), maternally inherited. Read More

BMC Pregnancy Childbirth 2018 Nov 21;18(1):451. Epub 2018 Nov 21.

Department of Obstetrics and Gynaecology, United Christian Hospital, 130 Hip Wo Street, Kwun Tong, Hong Kong.

Background: The use of intrauterine balloon tamponade to manage postpartum hemorrhage is increasing. However, there is lack of studies on the menstrual and reproductive outcomes after such treatment. The purpose of this study is to explore the menstrual and reproductive outcomes for patients who had been managed by intrauterine balloon tamponade for severe postpartum hemorrhage in her index pregnancy. Read More

BJOG 2018 Nov 20. Epub 2018 Nov 20.

Institute of Metabolism and Systems Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.

Background: There is a substantial body of research evaluating ways to prevent and manage miscarriage, but studies do not report on the same outcomes.

Objective: To systematically review outcomes reported in existing miscarriage trials.

Search Strategy: MEDLINE, Embase, CINAHL and Cochrane were searched from inception until January 2017. Read More

BJOG 2018 Nov 20. Epub 2018 Nov 20.

Department of Obstetrics, AP-HP, Paris, France.

Objective: To investigate the obstetric outcome of women carriers of OXPHOS disorders mutation.

Design: A retrospective cohort study in a single tertiary centre SETTING: A review of obstetric history of women referred for prenatal screening of a mitochondrial disorder was performed.

Population: Women were divided into three groups: 1) women carrying mitochondrial DNA (mtDNA) mutations 2) healthy women with a family history of mtDNA-related OXPHOS disorder, 3) healthy women carrying heterozygote nuclear DNA (nDNA) mutations. Read More

Pediatr Int 2018 Nov 20. Epub 2018 Nov 20.

Department of Pediatrics, Hallym University Medical Center, Seoul, Korea.

Background: Ureaplasma spp. in the maternal genitourinary tract has come to the attention for is becoming more evident as a cause of preterm labor, spontaneous abortion, chorioamnionitis and adverse outcomes. However, a few controversies still remain, namely, whether it should be treated aggressively or not. Read More

Front Physiol 2018 6;9:1569. Epub 2018 Nov 6.

Department of Chemistry and Biochemistry, Facultad de Farmacia, CEU San Pablo University - CEU Universities, Madrid, Spain.

The prevalence of obesity in women of childbearing age around the globe has dramatically increased in the last decades. Obesity is characterized by a low-state chronic inflammation, metabolism impairment and oxidative stress, among other pathological changes. Getting pregnant in this situation involves that gestation will occur in an unhealthy environment, that can potentially jeopardize both maternal and fetal health. Read More

Zhonghua Fu Chan Ke Za Zhi 2018 Nov;53(11):768-775

Department of Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.

To investigate the clinical features, diagnosis and treatments of heterotopic pregnancy (HP) and demonstrate the outcomes of HP after the surgical treatment of ectopic pregnancies. A retrospective analysis was performed on 144 cases of HP in Womens Hospital, School of Medicine, Zhejiang University from January 2003 to December 2016. (1) Clinical features of HP:the average age of patients was (30. Read More

Zhonghua Fu Chan Ke Za Zhi 2018 Nov;53(11):755-760

Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.

To compare differences of clinical factors related to early pregnancy loss between invitro fertilization-embryo transfer (IVF-ET) treatment and natural pegnancy. A retrospective analysis was performed on the 363 cases of early pregnancy loss between Dec. 2015 to May 2016 in Peking University Third Hospital, during which 173 cases were after IVF-ET treatment (IVF-ET group) , and others were natural pregnancies (natural group) . Read More

Zhonghua Fu Chan Ke Za Zhi 2018 Nov;53(11):749-754

IVF Laboratory, Hospital for Reproductive Medicine Affiliated to Shandong University, Jinan 250021, China.

To evaluate the application value of the blastocysts derived from non-pronucleus (0PN) zygotes by the good quality blastocyst formation rate and the clinical outcomes of frozen-thawed blastocyst transfers. The good quality blastocyst formation rate derived from 0PN zygotes was compared with that derived from2 pronucleus (2PN) zygotes in in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles from January 2015 to December 2016. In addition, the clinical pregnancy, embryo implantation and live birth rates of frozen-thawed blastocyst transfers with blastocysts derived from 0PN and 2PN zygotes were analyzed on corresponding dates. Read More

Am J Cardiol 2018 Nov 3;122(10):1738-1744. Epub 2018 Aug 3.

Department of Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, New York City, New York; Division of Cardiothoracic Surgery, The State University of New York, Stony Brook Hospital, New York City, New York.

The optimal choice of prosthetic heart valve for women of child-bearing age is not well established. We conducted this retrospective cohort study to compare pregnancy outcomes and maternal mortality and morbidity, including long-term valve reoperation, between women with biologic and mechanical valve replacements. Women ≤50 years of age with prosthetic heart valve implantation and subsequent pregnancy in California, New Jersey, and New York State between 1990 to 2015 were identified using mandatory state inpatient databases. Read More

Reprod Biol 2018 Nov 14. Epub 2018 Nov 14.

Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, P.O. Box: 16635-148, Tehran, Iran. Electronic address:

More than two consecutive miscarriages in less than 20 weeks of gestation is defined as recurrent spontaneous miscarriage. Various causes such as uterine anatomical anomalies, genetic factors, and infectious and endocrine disorders have been reported for RPL. However, approximately 50% of the causes are unknown, which can be due to male factors. Read More

Acta Obstet Gynecol Scand 2018 Nov 15. Epub 2018 Nov 15.

Department of Obstetrics and Gynecology, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Introduction: About 8% of pregnant women in Sweden receive counseling for fear of childbirth (FOC) during pregnancy. Little is known about the long-term reproductive and obstetric outcome after counseling for FOC: Therefore, the objective of this historical cohort study was to compare the long-term reproductive and obstetric outcomes in women treated for FOC in their first pregnancy to women without FOC.

Material And Methods: All nulliparas consecutively referred for treatment of severe FOC in 2001-2007 (n=608) were compared to all other nullipara giving birth on the same day (n=431). Read More

J Nephrol 2018 Nov 15. Epub 2018 Nov 15.

OU Nephrology and Dialysis, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy.

The number of pregnancies in women with pregestational diabetes has been steadily increasing worldwide. These pregnancies are associated with an increased risk of a variety of complications, including miscarriages, congenital malformations, macrosomia, fetal growth restriction, preeclampsia, preterm delivery and stillbirth. In pregnant women with diabetic nephropathy it is important to evaluate both the effect of pregnancy on kidney function and the effect of kidney disease on pregnancy outcomes. Read More

Fertil Steril 2018 Nov 10. Epub 2018 Nov 10.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California, Los Angeles, California; Fertility and Surgical Associates of California, Thousand Oaks, California.

Objective: To evaluate the impact of segmental mosaicism on pregnancy outcomes from the transfer of embryos previously designated as euploid.

Design: Retrospective cohort analysis.

Setting: Single, private, high-volume fertility center. Read More

Fertil Steril 2018 Nov 10. Epub 2018 Nov 10.

New York University Langone Fertility Center, New York, New York.

Objective: To assess patient decisions regarding mosaic embryos and their impact on clinical outcomes.

Design: Review of patients who had genetic counseling regarding mosaic embryos.

Setting: Academic department. Read More

J Adolesc Health 2018 Nov 8. Epub 2018 Nov 8.

Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Purpose: Identification of trends in the ability of young single women to protect themselves from unwelcome pregnancy is essential for evaluation and development of policies and programs. We document trends over a 15-year period in sexual activity, contraceptive use, and reproductive outcomes in four countries for single women aged 15-24 years.

Methods: Using retrospective month-by-month reproductive and contraceptive calendars, we constructed annual sexual, contraceptive, and reproductive profiles. Read More

Placenta 2018 Nov 18;71:31-40. Epub 2018 Jun 18.

Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Introduction: Immune imbalance at the maternal-fetal interface plays a fundamental role in the pathogenesis of unexplained recurrent spontaneous abortion (URSA). Human amniotic epithelial cells (hAECs) possess pregnancy-friendly immunomodulatory effects. Here, we investigated how function of naive CD4 T cells from URSA patients is affected by hAECs. Read More