137,319 results match your criteria Minnesota Medicine [Journal]


Habit-like attention.

Curr Opin Psychol 2018 Nov 30;29:65-70. Epub 2018 Nov 30.

Department of Psychology, University of Minnesota, United States.

The control of selective attention is traditionally considered to be either goal-driven or stimulus-driven. Increasing research, however, has linked past experience to attentional selection. Effects of selection history may be transient, as in inter-trial priming, or durable. Read More

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November 2018
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Guidelines for reporting of statistics for clinical research in urology.

BJU Int 2018 Dec 8. Epub 2018 Dec 8.

Memorial Sloan Kettering Cancer Center.

In an effort to improve the quality of statistics in the clinical urology literature, statisticians at European Urology, The Journal of Urology, Urology and BJUI came together to develop a set of guidelines to address common errors of statistical analysis, reporting and interpretation. Authors should "break any of the guidelines if it makes scientific sense to do so" but would need to provide a clear justification. Adoption of the guidelines will in our view not only increase the quality of published papers in our journals but improve statistical knowledge in our field in general. Read More

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December 2018
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Members of Minority and Underserved Communities Set Priorities for Health Research.

Milbank Q 2018 Dec;96(4):675-705

Friends of Parkside.

Policy Points Engaging and involving underrepresented communities when setting research priorities could make the scientific research agenda more equitable, more just, and more responsive to their needs and values. Groups and individuals from minority and underserved communities strongly prioritized child health and mental health research, often choosing to invest at the highest possible level. Groups consisting of predominantly Native American or Arab American participants invested in culture and beliefs research at the highest level, while many groups did not select it at all. Read More

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December 2018
1 Read

Editor's Remarks January 2019.

Authors:
Steven M Harris

J Marital Fam Ther 2018 Dec 11. Epub 2018 Dec 11.

University of Minnesota.

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December 2018

Early Endovascular Thrombectomy for Large Vessel Ischemic Stroke Reduces Disability at 90 Days.

Acad Emerg Med 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurology, University of Minnesota, Minneapolis, Minnesota.

Anterior circulation large vessel occlusion (LVO) of the internal carotid or middle cerebral artery is one of the most devastating ischemic stroke subtypes. Prior to 2015, evidence supporting endovascular thrombectomy for acute ischemic stroke was limited. This was due to multiple factors, including low recanalization rates with previous generation thrombectomy devices, inadequate neuroimaging inclusion criteria (patients enrolled in trials lacked target LVO and/or had large pre-existing core infarcts), and selection bias-patients considered most likely to benefit from thrombectomy underwent the procedure outside of clinical trials. Read More

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December 2018
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Mothering under political violence: Post-traumatic symptoms, observed maternal parenting practices and child externalising behaviour.

Int J Psychol 2018 Dec 10. Epub 2018 Dec 10.

Bar-Ilan University, Ramat-Gan, Israel.

Using the family stress model as our conceptual framework, we explored whether observed maternal parenting practices (positive and coercive) account for the associations between mothers' post-traumatic stress symptoms and children's externalising behaviours. Mothers' self-reported post-traumatic stress symptoms, observed maternal practices, and reports of children's externalising behaviour were collected from 123 Israeli mothers and their children, who were exposed to ongoing rocket attacks in southern Israel. A structural equation model revealed that mothers' post-traumatic stress symptoms were linked with greater maternal coercive parenting practices, which in turn were associated with more externalising behaviours in children. Read More

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December 2018

The partitioning of gross primary production for young Eucalyptus tereticornis trees under experimental warming and altered water availability.

New Phytol 2018 Dec 11. Epub 2018 Dec 11.

Hawkesbury Institute for the Environment, Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia.

The allocation of carbon (C) is an important component of tree physiology that influences growth and ecosystem C storage. Allocation is challenging to measure, and its sensitivity to environmental changes such as warming and altered water availability is uncertain. We exposed young Eucalyptus tereticornis trees to +3°C warming and elimination of summer precipitation in the field using whole-tree chambers. Read More

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December 2018

Characterization of Campylobacter jejuni, Campylobacter upsaliensis, and a novel Campylobacter sp. in a captive non-human primate zoological collection.

J Med Primatol 2018 Dec 9. Epub 2018 Dec 9.

Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts.

Background: The aim of this study was to longitudinally investigate the prevalence and characterization of Campylobacter spp. from non-human primates primate (NHP) with a history of endemic diarrhea housed at Como Park Zoo.

Methods: Fecal samples from 33 symptom-free NHP belonging to eight different species were collected weekly for 9 weeks. Read More

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December 2018
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Regulatory Landscape in the United States.

Authors:
Pamela L Vetter

Clin Pharmacol Ther 2018 Dec 7. Epub 2018 Dec 7.

1Department of Research Administration, Mayo Clinic, Rochester, Minnesota, USA.

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December 2018

Engineering an EGFR-Binding Gp2 Domain for Increased Hydrophilicity.

Biotechnol Bioeng 2018 Dec 8. Epub 2018 Dec 8.

University of Minnesota - Twin Cities, Department of Chemical Engineering and Materials Science, 421 Washington Avenue SE, Minneapolis, MN.

The Gp2 domain is a 45 amino-acid scaffold that has been evolved for specific, high-affinity binding towards multiple targets, and was proven useful in molecular imaging and biological antagonism. It was hypothesized that Gp2 may benefit from increased hydrophilicity for improved physiological distribution as well as for physicochemical robustness. We identified seven exposed hydrophobic sites for hydrophilic mutations and experimentally evaluated single mutants, which yielded six mutations that do not substantially hinder expression, binding affinity or specificity (to epidermal growth factor receptor), and thermal stability. Read More

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December 2018
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Xenotransplantation literature update, September/October 2018.

Xenotransplantation 2018 Dec 7:e12475. Epub 2018 Dec 7.

Department of Surgery, Schultz Diabetes Institute, University of Minnesota, Minneapolis, Minnesota.

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December 2018
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The array of clinical phenotypes of males with mutations in Methyl-CpG binding protein 2.

Am J Med Genet B Neuropsychiatr Genet 2018 Dec 7. Epub 2018 Dec 7.

University of Alabama at Birmingham, Birmingham, Alabama.

Mutations in the X-linked gene MECP2 are associated with a severe neurodevelopmental disorder, Rett syndrome (RTT), primarily in girls. It had been suspected that mutations in Methyl-CpG-binding protein 2 (MECP2) led to embryonic lethality in males, however such males have been reported. To enhance understanding of the phenotypic spectrum present in these individuals, we identified 30 males with MECP2 mutations in the RTT Natural History Study databases. Read More

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December 2018
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Systemic mastocytosis in adults: 2019 update on diagnosis, risk stratification and management.

Am J Hematol 2018 Dec 8. Epub 2018 Dec 8.

Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Overview: Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast cells (MC) in extra-cutaneous organs.

Diagnosis: The major criterion is presence of multifocal clusters of abnormal MC in the bone marrow. Minor diagnostic criteria include elevated serum tryptase level, abnormal MC CD25 expression, and presence of KITD816V mutation. Read More

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December 2018
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Pharmacotherapy in Older Adults with Cardiovascular Disease: Report from an American College of Cardiology, American Geriatrics Society, and National Institute on Aging Workshop.

J Am Geriatr Soc 2018 Dec 7. Epub 2018 Dec 7.

Cardiovascular Division, Department of Internal Medicine, Washington University, St. Louis, Missouri.

Objectives: To identify the top priority areas for research to optimize pharmacotherapy in older adults with cardiovascular disease (CVD).

Design: Consensus meeting.

Setting: Multidisciplinary workshop supported by the National Institute on Aging, the American College of Cardiology, and the American Geriatrics Society, February 6-7, 2017. Read More

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December 2018

A Comparison of U.S. and Canadian Osteoporosis Screening and Treatment Strategies in Postmenopausal Women.

J Bone Miner Res 2018 Dec 7. Epub 2018 Dec 7.

Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.

The optimal approach to osteoporosis screening and treatment in postmenopausal women is unclear. We compared 1) the United States Preventive Services Task Force (USPSTF) and Osteoporosis Canada osteoporosis screening strategies; and 2) the National Osteoporosis Foundation (NOF) and Canadian treatment strategies. We used data from the prospective Women's Health Initiative Observational Study and Clinical Trials of women aged 50-79 years at baseline (n = 117,707 followed for self-reported fractures; n = 8,134 in bone mineral density [BMD] subset). Read More

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December 2018

The diversity of population responses to environmental change.

Ecol Lett 2018 Dec 9. Epub 2018 Dec 9.

Université Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, F-69622, Villeurbanne, France.

The current extinction and climate change crises pressure us to predict population dynamics with ever-greater accuracy. Although predictions rest on the well-advanced theory of age-structured populations, two key issues remain poorly explored. Specifically, how the age-dependency in demographic rates and the year-to-year interactions between survival and fecundity affect stochastic population growth rates. Read More

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December 2018

How are nitrogen availability, fine-root mass, and nitrogen uptake related empirically? Implications for models and theory.

Glob Chang Biol 2018 Dec 7. Epub 2018 Dec 7.

Department of Integrative Biology, University of Texas at Austin, 2415 Speedway, Austin, Texas, 78712.

Understanding the effects of global change in terrestrial communities requires an understanding of how limiting resources interact with plant traits to affect productivity. Here, we focus on nitrogen and ask whether plant community nitrogen uptake rate is determined (i) by nitrogen availability alone or (ii) by the product of nitrogen availability and fine-root mass. Surprisingly, this is not empirically resolved. Read More

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December 2018

Utility of adjuvant chemotherapy in patients receiving surgery and adjuvant radiotherapy for primary treatment of esthesioneuroblastoma.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota.

Background: Past research established that surgery plus adjuvant radiotherapy (S + AR) improves overall survival (OS) in esthesioneuroblastoma (ENB). However, it is unknown if the addition of adjuvant chemotherapy (AC) further improves survival. The primary objective of this study was to compare survival among patients treated with S + AR alone to patients who underwent S + AR + AC. Read More

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December 2018

Comparison of demographic data, disease severity and response to treatment, between dogs with atopic dermatitis and atopic-like dermatitis: a retrospective study.

Vet Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Veterinary Clinical Sciences and Surgery, Universidade Federal de Minas Gerais, 6627 Antônio Carlos Ave, Belo Horizonte, 31270-901, Brazil.

Background: Limited information is available describing the features of canine atopic-like dermatitis (ALD) compared with atopic dermatitis (AD).

Objectives: To compare demographic data, disease severity and response to therapy between ALD and AD dogs.

Animals: Two hundred and fifty-three atopic dogs with intradermal and serum allergen-specific IgE test results were selected retrospectively. Read More

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December 2018
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Gossypin inhibits gastric cancer growth by direct targeting of AURKA and RSK2.

Phytother Res 2018 Dec 10. Epub 2018 Dec 10.

China-US (Henan) Hormel Cancer Institute, Zhengzhou, Henan, China.

Gossypin is a flavone extracted from Hibiscus vitifolius, which has been reported to exhibit anti-inflammatory, antioxidant, and anticancer activities. However, the anticancer properties of gossypin and its molecular mechanism of action against gastric cancer have not been fully investigated. In the present study, we report that gossypin is an Aurora kinase A (AURKA) and RSK2 inhibitor that suppresses gastric cancer growth. Read More

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December 2018
1 Read
2.397 Impact Factor

Conversation Orientation Moderates the Relationship between Information Sharing of Medically Assisted Reproduction and Child Adjustment.

Fam Process 2018 Dec 10. Epub 2018 Dec 10.

Department of Family Medicine and Community Health, University of Minnesota Twin Cities, St. Paul, MN.

Parents who experienced infertility have increasingly used medically assisted reproduction (MAR) to add children to their families over the past few decades. These parents will need to decide if they will tell their children about being conceived using MAR. Although MAR information sharing operates within family contexts, little is known about the role of conversation orientation-one family contextual factor-in child outcomes associated with MAR information sharing in middle childhood. Read More

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December 2018

Genetically Informative Mediation Modeling Applied to Stressors and Personality-Disorder Traits in Etiology of Alcohol Use Disorder.

Behav Genet 2018 Dec 7. Epub 2018 Dec 7.

Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.

A statistical mediation model was developed within a twin design to investigate the etiology of alcohol use disorder (AUD). Unlike conventional statistical mediation models, this biometric mediation model can detect unobserved confounding. Using a sample of 1410 pairs of Norwegian twins, we investigated specific hypotheses that DSM-IV personality-disorder (PD) traits mediate effects of childhood stressful life events (SLEs) on AUD, and that adulthood SLEs mediate effects of PDs on AUD. Read More

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December 2018

Correction to: Alison Butler: papers in celebration of her 2018 ACS Alfred Bader Award in Bioorganic or Bioinorganic Chemistry.

Authors:
Lawrence Que

J Biol Inorg Chem 2018 Dec 7. Epub 2018 Dec 7.

Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN, 55455-0431, USA.

"In the original online publication, the Foreword was incorrectly attributed. The correct author is Lawrence Que, Jr." Read More

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December 2018

Indole-3-acetylaspartate and indole-3-acetylglutamate, the IAA-amide conjugates in the diploid strawberry achene, are hydrolyzed in growing seedlings.

Planta 2018 Dec 8. Epub 2018 Dec 8.

USDA/ARS Genetic Improvement of Fruit and Vegetables Laboratory, 10300 Baltimore Avenue, Beltsville, MD, 20705, USA.

Main Conclusion: Indole-3-acetylaspartate and indole-3-acetylglutamate are the stored auxin amino acid conjugates of the achene of the diploid strawberry and serve as sources of auxin during seedling growth. The edible part of the strawberry, a pseudocarp, has long been known to enlarge in response to auxin produced by the developing achenes, the botanical true fruit. Auxin homeostasis involves a complex interaction between biosynthesis, conjugate formation and hydrolysis, catabolism and transport. Read More

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December 2018
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Cultivar and phosphorus effects on switchgrass yield and rhizosphere microbial diversity.

Appl Microbiol Biotechnol 2018 Dec 7. Epub 2018 Dec 7.

Department of Soil, Water and Climate, University of Minnesota, 439 Borlaug Hall, 1991 Upper Buford Circle, St. Paul, MN, 55108, USA.

Switchgrass (Panicum virgatum L.) is a native perennial grass identified as a promising biofuel crop for production on marginal agricultural lands. As such, research into switchgrass fertility and the switchgrass rhizosphere microbiome has been ongoing in an effort to increase production sustainability. Read More

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December 2018

Local Stem Cell Therapy for Crohn's Perianal Fistulae.

Inflamm Bowel Dis 2018 Dec 11. Epub 2018 Dec 11.

Center for Inflammatory Bowel Disease, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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December 2018

Association between sphingolipids and cardiopulmonary fitness in coronary artery disease patients undertaking cardiac rehabilitation.

J Gerontol A Biol Sci Med Sci 2018 Dec 8. Epub 2018 Dec 8.

Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

The long term benefits conferred by cardiac rehabilitation (CR) in those with CAD are strongly linked with an improvement in cardiopulmonary fitness. This study aimed to determine the association between peripheral sphingolipids and cardiopulmonary fitness in CAD subjects undertaking CR. Patients with CAD (n=100, mean age=64±6 years, 85% male, mean years of education=17±3 years) underwent 6 months of CR with blood collected at baseline, 3 and 6 months. Read More

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December 2018
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Persistent upregulation of the β-tubulin tubb6, linked to muscle regeneration, is a source of microtubule disorganization in dystrophic muscle.

Hum Mol Genet 2018 Dec 6. Epub 2018 Dec 6.

Light Imaging Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.

In healthy adult skeletal muscle fibers microtubules form a three-dimensional grid-like network. In the mdx mouse, a model of Duchenne muscular dystrophy (DMD), microtubules are mostly disordered, without periodicity. These microtubule defects have been linked to the mdx mouse pathology. Read More

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December 2018

Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies.

Am J Clin Nutr 2018 Sep;108(3):453-475

Departments of Complex Genetics.

Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. Read More

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September 2018

Positive Experiences and Self-Gain Among Family Caregivers of Persons With Heart Failure.

Gerontologist 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.

Background: The majority of aging adults with heart failure (HF) receive support from a family caregiver. Most literature has emphasized the stressors and burden of caregiving, with less focus on positive self-gains associated with caregiving.

Methods And Results: Using an explanatory sequential design, we assessed self-gain by administering a survey to caregivers of a person with HF (n = 108) and then conducted qualitative semi-structured interviews with a subset (n = 16) of these caregivers. Read More

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December 2018
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Epidemiology of Bloodstream Infections in Hospitalized Children in the United States, 2009-2016.

Clin Infect Dis 2018 Dec 9. Epub 2018 Dec 9.

Pediatric Emergency Medicine, Chief of Critical Care Services, Children's Minnesota, Minneapolis, MN, USA.

Background: Bloodstream infections (BSIs) cause significant morbidity and mortality in children. Recent pediatric epidemiological data may inform prevention strategies and empiric antimicrobial therapy selection.

Methods: We conducted a retrospective cohort study from 2009-2016 utilizing demographic and microbiology data on inpatients <19 years using the Premier Healthcare Database. Read More

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December 2018

Microfluidic long DNA sample preparation from cells.

Lab Chip 2018 Dec 11. Epub 2018 Dec 11.

Department of Chemical Engineering and Materials Science, University of Minnesota - Twin Cities, 421 Washington Ave. SE, Minneapolis, MN 55455, USA.

A number of outstanding problems in genomics, such as identifying structural variations and sequencing through centromeres and telomeres, stand poised to benefit tremendously from emerging long-read genomics technologies such as nanopore sequencing and genome mapping in nanochannels. However, optimal application of these new genomics technologies requires facile methods for extracting long DNA from cells. These sample preparation tools should be amenable to automation and minimize fragmentation of the long DNA molecules by shear. Read More

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December 2018
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Self-assembly dynamics and antimicrobial activity of all l- and d-amino acid enantiomers of a designer peptide.

Nanoscale 2018 Dec 10. Epub 2018 Dec 10.

MDRCBB, Minnesota Dental Research Center for Biomaterials and Biomechanics, University of Minnesota, Minneapolis, Minnesota 55455, USA.

Recent studies have shown that antimicrobial peptides (AMPs) can self-assemble into supramolecular structures, but this has been overlooked as causative of their antimicrobial activity. Also, the higher antimicrobial potency of d-enantiomers compared to l-enantiomers of AMPs cannot always be attributed to their different resistance to protease degradation. Here, we tested all l- and d-amino acid versions of GL13K, an AMP derived from a human protein, to study structural links between the AMP secondary structure, supramolecular self-assembly dynamics, and antimicrobial activity. Read More

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December 2018
7.394 Impact Factor

Correction: Controlled p-type substitutional doping in large-area monolayer WSe crystals grown by chemical vapor deposition.

Nanoscale 2018 Dec 11. Epub 2018 Dec 11.

Department of Electrical and Computer Engineering, University of Minnesota, 200 Union Street, Minneapolis, Minnesota 55455, USA.

Correction for 'Controlled p-type substitutional doping in large-area monolayer WSe2 crystals grown by chemical vapor deposition' by Stephen A. Campbell et al., Nanoscale, 2018, 10, 21374-21385. Read More

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December 2018

The Basement Flight.

J Hosp Med 2018 Nov 28. Epub 2018 Nov 28.

Departments of Medicine and Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

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November 2018

A minimum information standard for reproducing bench-scale bacterial cell growth and productivity.

Commun Biol 2018 6;1:219. Epub 2018 Dec 6.

Joint Initiative for Metrology in Biology, 443 Via Ortega, Room 325, Stanford, CA 94305 USA.

Reproducing, exchanging, comparing, and building on each other's work is foundational to technological advances. Advancing biotechnology calls for reliable reuse of engineered organisms. Reliable reuse of engineered organisms requires reproducible growth and productivity. Read More

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December 2018

Improvements in Thigh Strength Symmetry Are Modestly Correlated With Changes in Self-Reported Function After Anterior Cruciate Ligament Reconstruction.

Orthop J Sports Med 2018 Nov 28;6(11):2325967118807459. Epub 2018 Nov 28.

Orthopedics Biomechanics Laboratory and Sports Medicine Center, Mayo Clinic, Rochester, Minnesota, USA.

Background: The association between quadriceps strength and functional outcomes after anterior cruciate ligament reconstruction (ACLR) is a focus of current research, while evaluations of hamstring strength are limited, despite the frequent use of hamstring autografts.

Purpose/hypothesis: The purpose of this study was to determine the relationship between changes in quadriceps and hamstring strength symmetry and self-reported outcomes before ACLR and at 12 and 24 weeks after surgery. We hypothesized that improvements in quadriceps and hamstring strength symmetry would be correlated with improvements in self-reported outcome measures within the first 6 months after ACLR. Read More

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November 2018

Mapping a Novel Black Spot Resistance Locus in the Climbing Rose Brite Eyes™ ('RADbrite').

Front Plant Sci 2018 26;9:1730. Epub 2018 Nov 26.

USDA-ARS National Clonal Germplasm Repository, Corvallis, OR, United States.

Rose black spot, caused by , is one of the most devastating foliar diseases of cultivated roses ( spp.). The globally distributed pathogen has the potential to cause large economic losses in the outdoor cultivation of roses. Read More

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November 2018
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16S rRNA Gene Amplicon Data Set-Based Bacterial Diversity in a Water-Soil Sample from Pangong Tso Lake, a High-Altitude Grassland Lake of the Northwest Himalayas.

Microbiol Resour Announc 2018 Nov 1;7(17). Epub 2018 Nov 1.

Faculty of Applied Sciences and Biotechnology, Shoolini University, Solan, Himachal Pradesh, India.

We report here 16S rRNA-based bacterial diversity existing during freezing conditions in a high-altitude Himalayan lake through sequencing a 16S rRNA gene amplicon data set. A total of 121,857 high-quality reads were obtained; 40.78% of the bacterial population was classified to the genus level, while 1. Read More

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November 2018

Draft Genome Sequences for a Diverse Set of Seven and Species.

Microbiol Resour Announc 2018 Oct 25;7(16). Epub 2018 Oct 25.

Minnesota Department of Health Public Health Laboratory, St. Paul, Minnesota, USA.

is a complex genus that includes commensal and pathogenic species that pose a public health threat to humans. While the pathogenic species have been studied extensively, many commensals have limited genomic information available. Here, we present 24 draft genomes for a diverse set of 7 and species. Read More

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October 2018

Effect of Internet-based Cognitive Behavioral Humanistic and Interpersonal Training vs. Internet-based General Health Education on Adolescent Depression in Primary Care: A Randomized Clinical Trial.

JAMA Netw Open 2018 Nov;1(7)

Department of General Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.

Importance: Although 13-20% of American adolescents experience a depressive episode annually, no scalable primary care model for adolescent depression prevention is currently available.

Objective: To study whether CATCH-IT (Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training) reduces the hazard for depression in at-risk adolescents identified in primary care, as compared to a general health education attention control (HE).

Design: The Promoting AdolescenT Health (PATH) study compares CATCH-IT and HE in a phase 3 single-blind multicenter randomized attention control trial. Read More

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November 2018
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Multifactorial Origin of Exertional Rhabdomyolysis, Recurrent Hematuria, and Episodic Pain in a Service Member with Sickle Cell Trait.

Case Rep Genet 2018 7;2018:6898546. Epub 2018 Nov 7.

Consortium for Health and Military Performance, Department of Military and Emergency Medicine, Hébert School of Medicine, Uniformed Services University, 4301 Jones Bridge Rd., Bethesda, MD 20184, USA.

Individuals with Sickle Cell Trait (SCT), generally considered a benign carrier state of hemoglobin S (HbAS), are thought to be at risk for exertional rhabdomyolysis and hematuria, conditions that can also be caused by various other acquired and inherited factors. We report an SCT positive service member with an exertional rhabdomyolysis event, recurrent hematuria with transient proteinuria, and episodic burning pain in the lower extremities. Clinical and genetic studies revealed the multifactorial nature of his complex phenotype. Read More

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November 2018

Reactions of Diaziridines with Benzynes Give N-Arylhydrazones.

Org Lett 2018 Dec 11. Epub 2018 Dec 11.

Department of Chemistry , University of Minnesota , 207 Pleasant Street SE , Minneapolis , Minnesota 55455 , United States.

Reactions of thermally generated benzynes with diaziridines are reported. These trapping reactions follow the same pathway as reported earlier by Heine and co-workers with electron-deficient alkynes. The resulting N-arylhydrazones were obtained efficiently in a single step. Read More

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December 2018

Performance metrics and enabling technologies for nanoplasmonic biosensors.

Nat Commun 2018 Dec 10;9(1):5263. Epub 2018 Dec 10.

Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland.

Nanoplasmonic structures can tightly confine light onto a material's surface to probe biomolecular interactions not easily accessed by other sensing techniques. New and exciting developments in nanofabrication processes, nano-optical trapping, graphene devices, mid-infrared spectroscopy, and metasurfaces will greatly empower the performance and functionalities of nanoplasmonic sensors. Read More

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December 2018

Origin and evolution of pathogenic coronaviruses.

Nat Rev Microbiol 2018 Dec 10. Epub 2018 Dec 10.

CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China.

Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two highly transmissible and pathogenic viruses that emerged in humans at the beginning of the 21st century. Both viruses likely originated in bats, and genetically diverse coronaviruses that are related to SARS-CoV and MERS-CoV were discovered in bats worldwide. In this Review, we summarize the current knowledge on the origin and evolution of these two pathogenic coronaviruses and discuss their receptor usage; we also highlight the diversity and potential of spillover of bat-borne coronaviruses, as evidenced by the recent spillover of swine acute diarrhoea syndrome coronavirus (SADS-CoV) to pigs. Read More

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December 2018

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism.

Nat Neurosci 2018 Dec 10. Epub 2018 Dec 10.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.

Astrocytes, microglia, and tanycytes play active roles in the regulation of hypothalamic feeding circuits. These non-neuronal cells are crucial in determining the functional interactions of specific neuronal subpopulations involved in the control of metabolism. Recent advances in biology, optics, genetics, and pharmacology have resulted in the emergence of novel and highly sophisticated approaches for studying hypothalamic neuronal-glial networks. Read More

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December 2018

Cohort Analysis of Immigrant Rhetoric on Timely and Regular Access of Prenatal Care.

Obstet Gynecol 2018 Dec 4. Epub 2018 Dec 4.

Departments of Obstetrics & Gynecology, Divisions of Maternal-Fetal Medicine, Baylor College of Medicine & Texas Children's Hospital, Houston, Texas; St. Olaf College, Northfield, Minnesota; the University of Texas at Austin, Austin, Texas; and the National School for Tropical Medicine at Baylor College of Medicine, and the Department of Molecular & Human Genetics at Baylor College of Medicine, Houston, Texas.

Objective: To assess whether recent anti-immigration rhetoric is significantly associated with inadequate prenatal care.

Methods: This was a population-based cohort study (2011-2017). In their native language, patients were consented and queried regarding country of origin and time in the United States. Read More

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December 2018

2019 Directory of Christian Nursing Schools in North America.

J Christ Nurs 2019 Jan/Mar;36(1):16-21

Virginia Wolgemuth, PhD, RN, established and serves as chief nurse administrator of the University of Northwestern-St. Paul School of Nursing, Minnesota. She believes that nursing is a spiritual calling and a rewarding career.

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December 2018