54,373 results match your criteria Minimally Invasive Therapy & Allied Technologies [Journal]


Do electrical current and laser therapies improve bone remodeling during an orthodontic treatment with corticotomy?

Clin Oral Investig 2019 Feb 15. Epub 2019 Feb 15.

Graduate Program of Biomedical Sciences, Herminio Ometto University Center, UNIARARAS, Dr. Maximiliano Baruto, 500, Araras, SP, 13607-339, Brazil.

Objectives: Evaluate the bone remodeling during orthodontic movement with corticotomy when submitted to low-intensity electrical stimulation application (microcurrent-MC) and low-level laser therapy (LLLT).

Material And Methods: One hundred and fifty Wistar rats were divided into the following 5 groups: (C) submitted to tooth movement; (Cort) tooth movement/corticotomy; (Cort-L) tooth movement/corticotomy/laser AsGaAl 808 nm (4.96J/50s); (Cort-Mc) tooth movement/corticotomy/microcurrent (10 μA/5 min); (Cort-L-Mc) tooth movement/corticotomy and laser/microcurrent alternated. Read More

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http://dx.doi.org/10.1007/s00784-019-02845-9DOI Listing
February 2019

A mixed-integer linear programming optimization model framework for capturing expert planning style in low dose rate prostate brachytherapy.

Phys Med Biol 2019 Feb 15. Epub 2019 Feb 15.

Mechanical Engineering, University of Alberta, Edmonton, Alberta, CANADA.

Low dose rate (LDR) brachytherapy is a minimally invasive form of radiation therapy, used to treat prostate cancer, and it involves permanent implantation of radioactive sources (seeds) inside of the prostate gland. Treatment planning in brachytherapy involves a decision making process for the placement of the sources in order to deliver an effective dose of radiation to cancerous tissue in the prostate while sparing the surrounding healthy tissue. Such a decision making process can be modeled as a mixed-integer linear programming (MILP) problem. Read More

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http://dx.doi.org/10.1088/1361-6560/ab075cDOI Listing
February 2019

An osteoclast-responsive, injectable bone of bisphosphonated-nanocellulose that regulates osteoclast/osteoblast activity for bone regeneration.

Biomacromolecules 2019 Feb 15. Epub 2019 Feb 15.

An injectable bone may serve as a minimally invasive therapy for large orthopedic defects and osteoporosis and an alternative to allografting and surgical treatment. However, conventional bone substitutes lack the desirable biodegradability, bioresponsibility, and functionality to regulate the bone regeneration process. Here, we report an injectable, bioresponsive bone composed of bisphosphonate-modified nanocellulose (pNC) as a bone substitute for bone regeneration. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01767DOI Listing
February 2019

Lymphatic supermicrosurgery for the treatment of recurrent lymphocele and severe lymphorrhea.

Microsurgery 2019 Feb 14. Epub 2019 Feb 14.

International Lymphedema Center, Hiroshima University Hospital, Hiroshima, Japan.

Background: Lymphocele and lymphorrhea are frequent complications after lymph node excision. Recurrent lymphoceles and intractable lymphorrhea are particularly difficult to treat conservatively. We describe the outcomes of four patients with recurrent lymphocele and nine patients with persistent lymphorrhea that were treated by supermicrosurgery. Read More

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http://dx.doi.org/10.1002/micr.30435DOI Listing
February 2019
1 Read

Current management of glaucoma.

Med J Aust 2019 Feb 14. Epub 2019 Feb 14.

University of Sydney, Sydney, NSW.

Glaucoma is an irreversible progressive optic neuropathy, for which the major proven treatment is to lower the intraocular pressure (IOP). Five groups of IOP-lowering eye drops have varying mechanisms of action. Some drops, such as β-blockers and α-2 agonists, have potentially serious systemic side effects. Read More

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http://dx.doi.org/10.5694/mja2.50020DOI Listing
February 2019

[Four Patients Who Underwent Proton Beam Therapy after Debulking Surgery and Omental Wrapping of the Residual Tumor as a Spacer for Unresectable Local Recurrence of Rectal Cancer].

Gan To Kagaku Ryoho 2019 Jan;46(1):79-82

Dept. of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University.

We report 4 patients who underwent proton beam therapy after debulking surgery for unresectable local recurrence of rectal cancer. Case 1: A 55-year-old man underwent radiotherapy and systemic chemotherapy for local recurrence; however, the lesion exhibited evident regrowth. Combination therapy of debulking surgery, omental wrapping of the residual tumor as a spacer, and postoperative proton beam therapy was performed. Read More

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January 2019

Emerging nonsurgical and surgical techniques to treat erectile dysfunction: A systematic review of treatment options and published outcomes.

J Plast Reconstr Aesthet Surg 2018 Dec 26. Epub 2018 Dec 26.

Department of Plastic and Reconstructive Surgery, University of Southern California, Keck Hospital of USC, 1510 San Pablo Street, Suite 4000, Los Angeles, CA 90033, United States. Electronic address:

Erectile dysfunction (ED) is one of the most common causes of morbidity in male patients, with a prevalence of 50-60% in men aged 40-70 years. EDs may be caused by physical or psychological trauma, the former of which may be treatable through surgical intervention. Physical trauma may be further categorized as vasculogenic, neurogenic, or idiopathic in nature. Read More

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http://dx.doi.org/10.1016/j.bjps.2018.12.028DOI Listing
December 2018

Anal Sphincteroplasty in the Minimally Invasive Era: Assessment of National Trends and Complications.

Am Surg 2019 Jan;85(1):46-51

Fecal incontinence is a debilitating and underreported condition. Despite introduction of novel therapies in recent years, anal sphincteroplasty (AS) remains the surgical choice for certain patients. Previous reports have primarily focused on single-surgeon or single-center experience with AS. Read More

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January 2019

Aquablation of the prostate for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia.

Cochrane Database Syst Rev 2019 Feb 13;2:CD013143. Epub 2019 Feb 13.

Department of Urology, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Hwasun, Korea, South.

Background: New, minimally invasive surgeries have emerged as alternatives to transurethral resection of the prostate (TURP) for the management of lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). Aquablation is a novel, minimally invasive, water-based therapy, combining image guidance and robotics for the removal of prostatic tissue.

Objectives: To assess the effects of Aquablation for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia. Read More

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http://dx.doi.org/10.1002/14651858.CD013143.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373984PMC
February 2019

The motility regulator flhDC drives intracellular accumulation and tumor colonization of Salmonella.

J Immunother Cancer 2019 Feb 12;7(1):44. Epub 2019 Feb 12.

Department of Chemical Engineering, University of Massachusetts, 159 Goessmann Laboratory, 686 North Pleasant St, Amherst, MA, 01003, USA.

Background: Salmonella have potential as anticancer therapeutic because of their innate tumor specificity. In clinical studies, this specificity has been hampered by heterogeneous responses. Understanding the mechanisms that control tumor colonization would enable the design of more robust therapeutic strains. Read More

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http://dx.doi.org/10.1186/s40425-018-0490-zDOI Listing
February 2019

Endoscopic vacuum assisted wound closure (EVAC) device to treat esophageal and gastric leaks: assessing time to proficiency and cost.

Surg Endosc 2019 Feb 11. Epub 2019 Feb 11.

Department of Minimally Invasive Surgery, Baylor University Medical Center, Dallas, TX, USA.

Background: Endoluminal vacuum therapy (EVAC) is an emerging procedure used to treat anastomotic leaks and/or perforations that would otherwise require surgery. The aim of this study was to determine time to proficiency in EVAC and the cost effectiveness of the procedure.

Methods: We retrospectively reviewed a prospectively maintained IRB approved database for all patients undergoing EVAC after esophageal and gastric complications between October 2013 and December 2017. Read More

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http://dx.doi.org/10.1007/s00464-019-06685-2DOI Listing
February 2019

The train has left: Can surgeons still get a ticket to treat structural heart disease?

J Thorac Cardiovasc Surg 2019 Jan 15. Epub 2019 Jan 15.

Department of Cardiothoracic Surgery, The Heart Hospital Baylor Plano, Plano, Tex.

With the disruptive advancement of catheter-based technologies and minimally invasive techniques in structural heart disease, surgeons must obtain necessary skills to continue to serve this large patient population. We believe that surgeons are uniquely positioned to offer the full spectrum of therapy in structural heart disease (transcatheter, minimally invasive, and complex redo interventions), making them comprehensive valve specialists. Given the variability in structural heart training, we urgently recommend the establishment of a standardized curriculum and pathways for surgical trainees to gain proficiency in transcatheter technologies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00225223193003
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http://dx.doi.org/10.1016/j.jtcvs.2019.01.011DOI Listing
January 2019
1 Read

Are circulating microRNAs suitable for the early detection of malignant mesothelioma? Results from a nested case-control study.

BMC Res Notes 2019 Feb 11;12(1):77. Epub 2019 Feb 11.

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Buerkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.

Objective: Malignant mesothelioma is an aggressive cancer of the serous membranes. For the detection of the tumor at early stages non- or minimally-invasive biomarkers are needed. The circulating biomarkers miR-132-3p, miR-126-3p, and miR-103a-3p were analyzed in a nested case-control study using plasma samples from 17 prediagnostic mesothelioma cases and 34 matched asbestos-exposed controls without a malignant disease. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-019-4113-7DOI Listing
February 2019
3 Reads

Evaluation of novel imaging devices for nanoparticle-mediated fluorescence-guided lung tumor therapy.

Ann Thorac Surg 2019 Feb 8. Epub 2019 Feb 8.

Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada. Electronic address:

Background: Non-surgical and minimally-invasive approaches for early stage peripheral lung cancer are needed to avoid the known morbidity of surgery, particularly in high-risk patients. We have previously demonstrated the utility of multifunctional porphyrin-phospholipid nanoparticles (porphysomes) for fluorescence imaging and phototherapy following preferential accumulation into tumors. The objective of this study was to demonstrate the feasibility of porphysome-mediated imaging and photothermal therapy using a newly-developed fiberscope and thoracoscope. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.008DOI Listing
February 2019

Spontaneous Closed Rupture of Achilles Tendon Following Minimally Invasive Ultrasonic Energy Therapy: A Report of Two Cases.

Surg Technol Int 2019 Feb 11;34. Epub 2019 Feb 11.

Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio.

This paper presents two patients who sustained spontaneous closed Achilles tendon ruptures following minimally invasive ultrasonic energy therapy for non-insertional Achilles tendinopathy. In both cases, the patients underwent minimally invasive ultrasonic energy therapy using a commercially available device. In addition, the current evidence, through available literature, has been reviewed and presented. Read More

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February 2019
1 Read

Asian Society of Gynecologic Oncology International Workshop 2018.

J Gynecol Oncol 2019 Jan 14. Epub 2019 Jan 14.

Department of Obstetrics and Gynecology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.

The Asian Society of Gynecologic Oncology International Workshop 2018 on gynecologic oncology was held in the Ajou University Hospital, Suwon, Korea on the 24th to 25th August 2018. The workshop was an opportunity for Asian doctors to discuss the latest findings of gynecologic cancer, including cervical, ovarian, and endometrial cancers, as well as the future of fertility-sparing treatments, minimally invasive/radical/debulking surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. Clinical guidelines and position statement of Asian countries were presented by experts. Read More

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https://ejgo.org/DOIx.php?id=10.3802/jgo.2019.30.e39
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http://dx.doi.org/10.3802/jgo.2019.30.e39DOI Listing
January 2019
2 Reads

Multimodal imaging assessment and histologic correlation of the female rat pelvic floor muscles' anatomy.

J Anat 2019 Feb 10. Epub 2019 Feb 10.

Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, La Jolla, CA, USA.

Pelvic floor disorders negatively impact millions of women worldwide. Although there is a strong epidemiological association with childbirth, the mechanisms leading to the dysfunction of the integral constituents of the female pelvic floor, including pelvic floor skeletal muscles, are not well understood. This is in part due to the constraints associated with directly probing these muscles, which are located deep in the pelvis. Read More

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http://dx.doi.org/10.1111/joa.12943DOI Listing
February 2019
2.097 Impact Factor

Minimally invasive coronary artery bypass: Twenty-year experience.

J Thorac Cardiovasc Surg 2018 Dec 29. Epub 2018 Dec 29.

Department of Cardiac Surgery, University of Brescia, Brescia, Italy.

Objective: Minimally invasive direct coronary artery bypass for the left thoracic artery on the left anterior descending artery is a safe and less traumatic surgical technique. We retrospectively evaluated long-term outcomes in a large series of patients undergoing minimally invasive direct coronary artery bypass.

Methods: From 1997 to 2016, 1060 patients underwent minimally invasive direct coronary artery bypass: 646 patients (61%) with isolated proximal left anterior descending disease and 414 patients (39%) with multivessel disease as a part of hybrid coronary revascularization or in association with medical therapy. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2018.11.149DOI Listing
December 2018

Combined locoregional-immunotherapy for liver cancer.

J Hepatol 2019 Feb 6. Epub 2019 Feb 6.

Center for Interventional Oncology, Radiology and Imaging Sciences, NIH Clinical Center & Center for Cancer Research, National Institutes of Health, United States; NCI CCR Liver Cancer Program, United States.

Locoregional therapies are commonly used to treat patients with hepatocellular carcinoma. It has been noted for many years that locoregional therapies may have additional systemic effects other than simple tumor elimination. Immunological "side effects" have been described in response to locoregional therapies in animal studies and also in patients. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.01.027DOI Listing
February 2019
1 Read

Efficacy and Safety of Ablative Therapy in the Treatment of Patients with Metastatic Pheochromocytoma and Paraganglioma.

Cancers (Basel) 2019 Feb 7;11(2). Epub 2019 Feb 7.

Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Metastatic pheochromocytoma and paraganglioma (PPGL) are incurable neuroendocrine tumors. The goals of treatment include palliating symptoms and reducing tumor burden. Little is known about the use of radiofrequency ablation (RFA), cryoablation (CRYO), and percutaneous ethanol injection (PEI) to treat metastatic PPGL. Read More

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http://dx.doi.org/10.3390/cancers11020195DOI Listing
February 2019

Trends and Outcomes of Synchronous Resection of Colorectal Metastasis in the Modern Era-Analysis of Targeted Hepatic NSQIP Database.

J Surg Res 2019 Feb 5;238:35-40. Epub 2019 Feb 5.

Good Samaritan General Surgery Residency Program, Cincinnati, Ohio; TriHealth Cancer Institute, Cincinnati, Ohio. Electronic address:

Background: Previous studies using the NSQIP database to study hepatectomies lacked hepatic specific variables and outcomes. We used the targeted NSQIP hepatectomy database to examine the nationwide trend and the safety profile of synchronous liver and colorectal resection compared with hepatectomy alone for colorectal liver metastasis.

Methods: The targeted NSQIP hepatectomy database from 2014 was used to study patients who underwent hepatectomy for diagnosis of adenocarcinoma of the colon and rectum. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.021DOI Listing
February 2019
1 Read

Advancing Frontiers in Bone Bioprinting.

Adv Healthc Mater 2019 Feb 8:e1801048. Epub 2019 Feb 8.

Center for Minimally Invasive Therapeutics (C-MIT), University of California - Los Angeles, Los Angeles, CA, 90095, USA.

Three-dimensional (3D) bioprinting of cell-laden biomaterials is used to fabricate constructs that can mimic the structure of native tissues. The main techniques used for 3D bioprinting include microextrusion, inkjet, and laser-assisted bioprinting. Bioinks used for bone bioprinting include hydrogels loaded with bioactive ceramics, cells, and growth factors. Read More

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http://dx.doi.org/10.1002/adhm.201801048DOI Listing
February 2019

Platinum Nanoparticles to Enable Electrodynamic Therapy for Effective Cancer Treatment.

Adv Mater 2019 Feb 8:e1806803. Epub 2019 Feb 8.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, P. R. China.

Electrochemical therapy (EChT), by inserting electrodes directly into tumors to kill cancer cells under direct current (DC), is clinically used in several countries. In EChT, the drastic pH variation nearby the inserted electrodes is the main cause of tumor damage. However, its limited effective area and complex electrode configuration have hindered the clinical application of EChT in treating diverse tumor types. Read More

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http://dx.doi.org/10.1002/adma.201806803DOI Listing
February 2019

[Female urology: review of the development in the past 5 decades].

Aktuelle Urol 2019 Feb 7;50(1):39-55. Epub 2019 Feb 7.

Charité - Universitätsmedizin Berlin, Klinik für Urologie, Berlin.

Urogynaecology is a highly specialised interdisciplinary medical field. It aims to investigate and treat functional, static, endocrine and sexual disorders of the genitourinary system and pelvic area in a sustainable and holistic manner.The "Urological Functional Diagnostics and Female Urology" working group of the German Urologist Academy was founded in 1977. Read More

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http://dx.doi.org/10.1055/a-0826-4089DOI Listing
February 2019
1 Read

Important surgical concepts and techniques in inguinal lymph node dissection.

Curr Opin Urol 2019 Feb 5. Epub 2019 Feb 5.

Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida, USA.

Purpose Of Review: Penile cancer is a rare disease with significant physical and psychosocial morbidity. It has a propensity to spread to the inguinal lymph nodes where it can progress to the pelvis and beyond. Here, we present a contemporary review on the surgical management of the lymph nodes. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000591DOI Listing
February 2019
2.333 Impact Factor

How to assess and predict success or failure of intra-detrusor injections with onabotulinumtoxinA.

Adv Clin Exp Med 2019 Feb 5. Epub 2019 Feb 5.

Department of Urology, Jagiellonian University Medical College, Kraków, Poland.

Intra-detrusor injection therapy with onabotulinumtoxinA is generally accepted as a highly effective, minimally invasive and well-tolerated day procedure for patients with refractory overactive bladder (OAB) and neurogenic detrusor overactivity (NDO). The aim of this study was to summarize currently available methods of assessing treatment efficacy and risk factors that may influence the therapeutic effect of this approach. We found that there are discrepancies in the assessment methods. Read More

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http://dx.doi.org/10.17219/acem/90764DOI Listing
February 2019

Clinical characteristics and outcomes of immune checkpoint inhibitor-induced pancreatic injury.

J Immunother Cancer 2019 Feb 6;7(1):31. Epub 2019 Feb 6.

Departments of Gastroenterology, Hepatology & Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Immune checkpoint inhibitor (ICI)-induced pancreatic injury (ICIPI) is not well documented in the literature. We aimed to describe the clinical characteristics and outcomes of patients who developed ICIPI.

Methods: We reviewed the medical records of consecutive patients who had a confirmed diagnosis of ICIPI (Common Terminology Criteria for Adverse Events grade ≥ 3 lipase elevation with or without clinical symptoms) from April 2011 through April 2018. Read More

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http://dx.doi.org/10.1186/s40425-019-0502-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364483PMC
February 2019

Primary tumour resection in non-small-cell lung cancer patients with ipsilateral pleural dissemination (M1a): a population-based study.

Eur J Cardiothorac Surg 2019 Feb 4. Epub 2019 Feb 4.

Department of Thoracic Surgery, Centre of Thoracic Minimally Invasive Surgery, Peking University People's Hospital, Beijing, China.

Objectives: Non-small-cell lung cancer (NSCLC) patients with ipsilateral pleural dissemination (M1a) are generally contraindicated for surgery. However, several small-sample studies have demonstrated that they might benefit from surgery. We investigated the effects of primary tumour resection on survival in these patients. Read More

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http://dx.doi.org/10.1093/ejcts/ezy439DOI Listing
February 2019
1 Read

Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma.

PLoS One 2019 6;14(2):e0211117. Epub 2019 Feb 6.

Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, United States of America.

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic stroma with a poor lymphocyte infiltrate, in part driven by cancer-associated fibroblasts (CAFs). CAFs, which express fibroblast activation protein (FAP), contribute to immune escape via exclusion of anti-tumor CD8+ T cells from cancer cells, upregulation of immune checkpoint ligand expression, immunosuppressive cytokine production, and polarization of tumor infiltrating inflammatory cells. FAP is a post-proline peptidase selectively expressed during tissue remodeling and repair, such as with wound healing, and in the tumor microenvironment by cancer-associated fibroblasts. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211117PLOS
February 2019
1 Read

Miniaturization in Glaucoma Monitoring and Treatment: A Review of New Technologies That Require a Minimal Surgical Approach.

Ophthalmol Ther 2019 Feb 6. Epub 2019 Feb 6.

University Eye Clinic, Ruhr University, Bochum, Germany.

In the management of glaucoma, recent and upcoming innovations have the potential to contribute to both the efficacy of intraocular pressure (IOP) monitoring and the number of available treatment options. These new devices and procedures have two things in common: they are part of the trend in medicine towards miniaturization, and they require a limited surgical procedure to become effective. This review focuses on the Eyemate (Argos) intraocular sensor, which offers a new way to reliably measure 24 h IOP, and on intraocular sustained release systems for pharmacological glaucoma therapy. Read More

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http://link.springer.com/10.1007/s40123-019-0161-2
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http://dx.doi.org/10.1007/s40123-019-0161-2DOI Listing
February 2019
2 Reads

Targeting cyclin-dependent kinases in gastrointestinal cancer therapy.

Discov Med 2019 Jan;27(146):27-36

Institute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.

Cyclin-dependent kinases (CDKs) play an important role in cell-cycle progression. CDKs are positively modulated by regulatory mitotic cyclins and negatively controlled by endogenous CDK inhibitors (CDKIs) cyclically as cells progress through different cell cycles of transitions. When activated by cyclins, cyclin-CDK complexes were able to facilitate the transition of cell cycle from one phase to the next, e. Read More

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January 2019

[The combined endoscopic treatment of the patient presenting with a large orolaryngopharyngeal papilloma].

Vestn Otorinolaringol 2018 ;83(6):48-50

The Endoscopic Department of the Rostov Research Institute of Oncology, Rostov-on-Don, Russian Federation, 344037.

The present article was designed to illustrate the potential for the combined treatment of a orolaryngopharyngeal papilloma under the conditions of an out-patient setting with the application of the minimally invasive endoscopic surgical intervention, the so-called photodynamic therapy (PDT). The authors describe the clinical case which demonstrate the possibilities for using photodynamic therapy as a component of the combined treatment of papilloma of the hypopharynx including its radical removal. The application of the PDT mdethod in the clinical case reported in the present article was aimed at preventing the recurrence of papillomatosis of the upper respiratory tract. Read More

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http://dx.doi.org/10.17116/otorino20188306148DOI Listing
January 2018

Responsible, Safe, and Effective Use of Antithrombotics and Anticoagulants in Patients Undergoing Interventional Techniques: American Society of Interventional Pain Physicians (ASIPP) Guidelines.

Pain Physician 2019 Jan;22(1S):S1-S74

Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Background: Interventional pain management involves diagnosis and treatment of chronic pain. This specialty utilizes minimally invasive procedures to target therapeutics to the central nervous system and the spinal column. A subset of patients encountered in interventional pain are medicated using anticoagulant or antithrombotic drugs to mitigate thrombosis risk. Read More

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January 2019
2 Reads
3.542 Impact Factor

Long-term effects of intracapsular debulking and adjuvant somatostatin analogs for growth hormone-secreting pituitary macroadenoma: 10 years of experience in a single institute.

World Neurosurg 2019 Feb 1. Epub 2019 Feb 1.

Department of Minimally Invasive Skull Base Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Physical Therapy, Hung Kuang University, Taichung, Taiwan. Electronic address:

Objective: Long-term effects of endoscopic endonasal transsphenoidal intracapsular debulking and adjuvant somatostatin analogs were evaluated in patients with growth hormone secreting pituitary macroadenomas.

Methods: We retrospectively reviewed the medical records of 45 patients with acromegalic macroadenoma who underwent endonasal endoscopic transsphenoidal intracapsular debulking and received adjuvant somatostatin analogs (octreotide) between 2006 and 2015, who had more than 1 year of follow-up. To evaluate the predictive factors for 1 year and long-term biochemical outcomes, univariate and multivariate analyses were performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193022
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http://dx.doi.org/10.1016/j.wneu.2019.01.125DOI Listing
February 2019
2 Reads

A Biocompatible Therapeutic Catheter-Deliverable Hydrogel for In Situ Tissue Engineering.

Adv Healthc Mater 2019 Feb 4:e1801147. Epub 2019 Feb 4.

Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.

Hydrogels have emerged as a diverse class of biomaterials offering a broad range of biomedical applications. Specifically, injectable hydrogels are advantageous for minimally invasive delivery of various therapeutics and have great potential to treat a number of diseases. However, most current injectable hydrogels are limited by difficult and time-consuming fabrication techniques and are unable to be delivered through long, narrow catheters, preventing extensive clinical translation. Read More

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http://dx.doi.org/10.1002/adhm.201801147DOI Listing
February 2019

Evolution of Nanoparticle-Mediated Photodynamic Therapy: From Superficial to Deep-Seated Cancers.

Molecules 2019 Jan 31;24(3). Epub 2019 Jan 31.

Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan 350, Taiwan.

Enthusiasm for photodynamic therapy (PDT) as a potential therapeutic intervention for cancer has increased exponentially in recent decades. Photodynamic therapy constitutes a clinically approved, minimally invasive treatment modality that uses a photosensitizer (light absorbing molecule) and light to kill cancer cells. The principle of PDT is, when irradiated with a light of a suitable wavelength, a photosensitizer absorbs the light energy and generates cytotoxic free radicals through various mechanisms. Read More

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http://www.mdpi.com/1420-3049/24/3/520
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http://dx.doi.org/10.3390/molecules24030520DOI Listing
January 2019
1 Read

Endoscopic arytenoid abduction lateropexy for the treatment of neonatal bilateral vocal cord paralysis - Long-term results.

Int J Pediatr Otorhinolaryngol 2019 Jan 22;119:147-150. Epub 2019 Jan 22.

Department of Otorhinolaryngology and Head and Neck Surgery Faculty of Medicine, University of Szeged, Szeged, Hungary.

Objectives: Bilateral vocal cord paralysis often causes severe dyspnea requiring an early airway intervention in neonates. Endoscopic arytenoid abduction lateropexy (EAAL) with suture is a quick, reversible, minimally-invasive vocal cord lateralizing technique to enlarge the glottis. The arytenoid cartilage is directly lateralized to a normal abducted position. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.01.032DOI Listing
January 2019

Surgical Management of Superficial Peritoneal Adolescent Endometriosis.

J Pediatr Adolesc Gynecol 2019 Jan 29. Epub 2019 Jan 29.

Division of Gynecology, Department of Surgery, Boston Children's Hospital; Division of Minimally Invasive Surgery, Brigham & Women's Hospital; Boston Center for Endometriosis; Harvard Medical School, Boston, Massachusetts.

Background: Adolescent endometriosis typically presents as Stage I with superficial peritoneal disease [SPD] and less commonly as Stage III or IV with deeply infiltrative disease [DIE]. Endometriosis lesions can be destroyed (cautery or laser), cutting out the discrete lesion with excision and destroyed, or radically excised with removal of the lesion and surrounding tissue. It has been shown to be beneficial to excise DIE to improve pain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10833188193000
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http://dx.doi.org/10.1016/j.jpag.2019.01.005DOI Listing
January 2019
3 Reads

Detailed Method for Intrathecal Delivery of Gene Therapeutics by Direct Lumbar Puncture in Mice.

Methods Mol Biol 2019 ;1937:305-312

Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA.

Delivery of viral vectors directly into the central nervous system (CNS) has emerged as an important tool for the refinement of gene therapy. Intrathecal delivery by direct lumbar puncture in conscious rodents offers a minimally invasive approach that avoids tissue damage and/or destruction. Here we describe delivery of small quantities of viral vector product to the intrathecal space of rodents via direct lumbar puncture aided by a catheter. Read More

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http://dx.doi.org/10.1007/978-1-4939-9065-8_20DOI Listing
January 2019

Exercise Training Does Improve Cardiorespiratory Fitness in Post-Bariatric Surgery Patients.

Obes Surg 2019 Feb 1. Epub 2019 Feb 1.

Department of Physical Therapy, Integrative Physiologic Laboratory, College of Applied Health Sciences, University of Illinois at Chicago (UIC), Chicago, IL, USA.

Although exercise is recognized as an important component of the management for patients following bariatric surgery (BS), its effectiveness on cardiorespiratory fitness (CRF) is still unclear. To investigate this relationship between BS and CRF, a systematic review was conducted in the MEDLINE database. The literature search included studies involving exercise training in patients following BS. Read More

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http://dx.doi.org/10.1007/s11695-019-03731-9DOI Listing
February 2019
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Role of digital single-operator cholangioscopy in the diagnosis and treatment of biliary disorders.

World J Gastrointest Endosc 2019 Jan;11(1):31-40

Department of Interventional Gastroenterology, Clinic of Gastroenterology, Acibadem City Clinic Tokuda Hopsital, Sofia 1407, Bulgaria.

Due to the need for improvement in the diagnosis and minimally invasive therapy of the bile duct disorders new technologies for cholangioscopy have been recently developed. Per-oral cholangioscopy has become an important diagnostic and therapeutic tool leading to avoidance of aggressive and unnecessary surgery in many clinical scenarios. This paper focuses on the newly developed SpyGlass DS technology, its advantages, and the technique of single-operator cholangioscopy (SOC), biliary indications and possible adverse events. Read More

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http://dx.doi.org/10.4253/wjge.v11.i1.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354115PMC
January 2019
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Multidisciplinary approach for multifocal, bilobar hepatocellular carcinoma: A case report and literature review.

World J Hepatol 2019 Jan;11(1):119-126

Department of Surgery, University of Washington, Seattle, WA 98195, United States.

Background: Hepatocellular carcinoma (HCC) is the second most lethal malignancy worldwide. There has been virtually no change in the survivability of HCC in spite of improvement in therapies. Surgery is considered the ideal first, curative intervention, however most patients present in advanced stages with unresectable disease. Read More

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http://dx.doi.org/10.4254/wjh.v11.i1.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354116PMC
January 2019

An anti-inflammatory peptide and brain-derived neurotrophic factor-modified hyaluronan-methylcellulose hydrogel promotes nerve regeneration in rats with spinal cord injury.

Int J Nanomedicine 2019 18;14:721-732. Epub 2019 Jan 18.

Institute of TBI and Neuroscience, Characteristic Medical Center of Chinese People's Armed Police Force (PAP), Tianjin Key Laboratory of Neurotrauma Repair, Tianjin 300162, China,

Background: Traumatic spinal cord injury (SCI) causes neuronal death, demyelination, axonal degeneration, inflammation, glial scar formation, and cystic cavitation resulting in interruption of neural signaling and loss of nerve function. Multifactorial targeted therapy is a promising strategy for SCI.

Methods: The anti-inflammatory peptide KAFAKLAARLYRKALARQLGVAA (KAFAK) and brain-derived neurotrophic factor (BDNF)-modified hyaluronan-methylcellulose (HAMC) hydrogel was designed for minimally invasive, localized, and sustained intrathecal protein delivery. Read More

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http://dx.doi.org/10.2147/IJN.S187854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342221PMC
January 2019

[Looking back 2018--focused on gastric cancer].

Authors:
Ziyu Li Xiangyu Gao

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Jan;22(1):1-8

Department of Gastrointestinal Surgery,Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China.

China is a country with high incidence of gastric cancer, most of which are advanced gastric cancer, accounting for about half of the new cases in the world. Environmental factors play a crucial role in the occurrence and development of gastric cancer. Helicobacter pylori and Epstein Barr virus(EBV) infection have been confirmed as one of the important pathogenic factors of gastric cancer. Read More

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January 2019
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The incidence of and risk factors for complications when removing a single uterine fibroid during cesarean section: a retrospective study with use of two comparison groups.

J Matern Fetal Neonatal Med 2019 Jan 30:1-8. Epub 2019 Jan 30.

e Laboratory of Human Physiology, Phystech BioMed School, Faculty of Biological & Medical Physics, Moscow Institute of Physics and Technology (State University) , Moscow State University, Inststitutskii per 9 , Dolgoprudny, Moscow region , Russia.

Purpose: To determine the incidence of and risk factors for perioperative complications in women with a single uterine fibroid, who had a cesarean myomectomy (CM).

Methods: This was a retrospective study of women who had a CM between 2015-2016. They were compared versus women who had a cesarean section (CS) alone and nonpregnant women who had a laparotomic myomectomy (LM). Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1570124DOI Listing
January 2019
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Enhanced local cancer therapy using a CA4P and CDDP co-loaded polypeptide gel depot.

Biomater Sci 2019 Jan 30. Epub 2019 Jan 30.

Department of Bioengineering, California Nanosystems Institute (CNSI), Jonsson Comprehensive Cancer Center, and Center for Minimally Invasive Therapeutics, University of California, Los Angeles (UCLA), 90095, USA. and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, USA.

Cancer combination therapy based on drug co-delivery systems provides an effective strategy for enhancing treatment efficacy and reducing side effects. In this work, a new strategy through co-delivery of combretastatin A4 disodium phosphate (CA4P) and cisplatin (CDDP) was developed for the local treatment of colon cancer, through an in situ thermo-gelling hydrogel (mPEG-b-PELG). The results indicated that this material possessed concentration-dependent thermogelling properties and tunable in vivo biodegradability. Read More

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http://xlink.rsc.org/?DOI=C8BM01442F
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http://dx.doi.org/10.1039/c8bm01442fDOI Listing
January 2019
3 Reads

In-vivo testing of a bioresorbable phosphate-based optical fiber.

J Biophotonics 2019 Jan 29:e201800397. Epub 2019 Jan 29.

Politecnico di Torino, Department of Applied Science and Technology and RU INSTM, Torino, Italy.

Optical fibers have recently attracted a noticeable interest for biomedical applications since they provide a minimally invasive method for in-vivo sensing, imaging techniques, deep-tissue photodynamic therapy or optogenetics. The silica optical fibers are the most commonly used because they offer excellent optical properties and they are readily available at a reasonable price. The fused silica is a biocompatible material, but it is not bioresorbable so it does not decompose in the body and the fibers must be ex-planted after in-vivo use and their fragments can present a considerable risk to the patient when the fiber breaks. Read More

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http://dx.doi.org/10.1002/jbio.201800397DOI Listing
January 2019

Multicenter retrospective study to evaluate the efficacy and safety of the double-flap technique as antireflux esophagogastrostomy after proximal gastrectomy (rD-FLAP Study).

Ann Gastroenterol Surg 2019 Jan 11;3(1):96-103. Epub 2018 Oct 11.

Department of Gastroenterological Surgery Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.

Aim: As a result of the difficulty in effective prevention of gastroesophageal reflux, no standard reconstruction procedure after proximal gastrectomy (PG) has yet been established. The double-flap technique (DFT), or Kamikawa procedure, is an antireflux reconstruction procedure in esophagogastrostomy. The efficacy of DFT has recently been reported in several studies. Read More

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http://dx.doi.org/10.1002/ags3.12216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345660PMC
January 2019
1 Read