55,259 results match your criteria Minimally Invasive Therapy & Allied Technologies [Journal]


Endovascular Treatment for Acute Ischemic Stroke: Clinical Outcomes Under Pressure.

Eur J Neurol 2019 Apr 19. Epub 2019 Apr 19.

Second Department of Neurology, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Current guidelines from the European Stroke Organisation (ESO) and the European Society for Minimally Invasive Neurological Therapy (ESMINT) on the endovascular treatment (EVT) for large vessel occlusion (LVO) patients with acute ischemic stroke (AIS) suggest to maintain blood pressure (BP) levels below 180/105 mmHg both during and for 24 hours after EVT, however grading this recommendation as weak due to the low quality of existing evidence. The association between functional outcomes following EVT and the various BP parameters, measured hourly during the first 24 hours after admission, was further investigated in the retrospective analysis of 378 LVO patients by Cho et al. This article is protected by copyright. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ene.13969
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http://dx.doi.org/10.1111/ene.13969DOI Listing
April 2019
1 Read

Closed-loop insulin delivery in end-of-life care: a case report.

Diabet Med 2019 Apr 19. Epub 2019 Apr 19.

Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

Background: Glucose management for people with diabetes approaching the end of life can be very challenging. The aim is to balance a minimally invasive approach with avoidance of symptomatic hypo- and hyperglycaemia.

Case Report: We present a case of a hospitalized individual whose glucose was managed with closed-loop insulin delivery within a randomized controlled trial setting during a period of terminal illness. Read More

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http://dx.doi.org/10.1111/dme.13974DOI Listing

Video-assisted thoracoscopic lobectomy: which patients require postoperative physiotherapy?

Physiotherapy 2019 Jan 11. Epub 2019 Jan 11.

Department of Thoracic Surgery, Heart of England NHS Foundation Trust, Bordesley Green East, Birmingham B9 5SS, UK. Electronic address:

Objectives: Following major thoracic surgery physiotherapy is recommended to improve reduced lung volume, aid secretion clearance, and improve mobility, however, in many centres physiotherapy provision is variable following minimally invasive video-assisted thoracoscopic surgery (VATS). The objective of this study was to observe frequency of problems potentially amenable to physiotherapy following VATS lobectomy, and to identify associated baseline factors of patients in whom physiotherapy may be beneficial.

Methods: A prospective observational study was performed including all consecutive cancer patients undergoing VATS lobectomy in a regional centre over 4years (2012-2016). Read More

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http://dx.doi.org/10.1016/j.physio.2019.01.001DOI Listing
January 2019
2 Reads

Prophylactic protocol for dental care in ligneous gingivitis due to severe plasminogen deficiency: Case report and review of literature.

Haemophilia 2019 Apr 17. Epub 2019 Apr 17.

Clinical Medicine I, Department of Medicine, University of Padua, Padua, Italy.

Introduction: Severe plasminogen (PLG) deficiency causes ligneous conjunctivitis, a rare disease characterized by the growth of fibrin-rich pseudomembranes on mucosal surfaces; gums involvement leads to ligneous gingivitis (LG). Specific therapy for LG is not available yet. We report a prophylactic treatment with enoxaparin and fresh frozen plasma (FFP) for invasive dental procedures in a patient with LG, and a review of literature on LG treatment. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hae.13745
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http://dx.doi.org/10.1111/hae.13745DOI Listing
April 2019
1 Read

Three-dimensional Therapy Needle Applicator Segmentation for Ultrasound-guided Focal Liver Ablation.

Med Phys 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Biophysics.

Purpose: Minimally invasive procedures, such as microwave ablation, are becoming first-line treatment options for early-stage liver cancer due to lower complication rates and shorter recovery times than conventional surgical techniques. Although these procedures are promising, one reason preventing widespread adoption is inadequate local tumour ablation leading to observations of higher local cancer recurrence compared to conventional procedures. Poor ablation coverage has been associated with two-dimensional (2D) ultrasound (US) guidance of the therapy needle applicators and has stimulated investigation into the use of three-dimensional (3D) US imaging for these procedures. Read More

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http://dx.doi.org/10.1002/mp.13548DOI Listing

Segmental Liver Stiffness Evaluated with Magnetic Resonance Elastography Is Responsive to Endovascular Intervention in Patients with Budd-Chiari Syndrome.

Korean J Radiol 2019 May;20(5):773-780

Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Objective: To assess segmental liver stiffness (LS) with MRI before and after endovascular intervention in patients with Budd-Chiari syndrome (BCS).

Materials And Methods: Twenty-three patients (13 males and 10 females; mean age, 42.6 ± 12. Read More

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http://dx.doi.org/10.3348/kjr.2018.0767DOI Listing

Combination of intratumoural micellar paclitaxel with radiofrequency ablation: efficacy and toxicity in rodents.

Eur Radiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Ultrasound, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education /Beijing), Peking University Cancer Hospital & Institute, Beijing, 100142, China.

Objectives: To determine whether radiofrequency ablation (RFA) is more effective when combined with intratumoural injection (IT) than with intravenous injection (IV) of micelles.

Materials And Methods: Balb/c mice bearing 4T1 breast cancer were used. The tumour drug accumulation and biodistribution in major organs were evaluated at different time points after IT, IV, IT+RFA and IV+RFA. Read More

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http://dx.doi.org/10.1007/s00330-019-06207-7DOI Listing

Arthroscopic matrix-associated, injectable autologous chondrocyte transplantation of the hip: significant improvement in patient-related outcome and good transplant quality in MRI assessment.

Knee Surg Sports Traumatol Arthrosc 2019 Apr 16. Epub 2019 Apr 16.

Medical Faculty Mannheim, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany.

Purpose: Acetabular chondral lesions are common in patients with FAI. For large full-thickness cartilage defects, arthroscopic matrix-associated autologous chondrocyte transplantation (MACT) using an injectable in situ crosslinking product is an option. Aim of the study was to evaluate clinical and MRI results 12 months after MACT of acetabular cartilage defects in FAI patients. Read More

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http://dx.doi.org/10.1007/s00167-019-05466-7DOI Listing

The effectiveness of group training of cognitive behavioral therapy-based stress management on anxiety, hardiness and self-efficacy in female medical students.

J Educ Health Promot 2019 15;8:49. Epub 2019 Feb 15.

Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran.

Introduction: The present study aimed to investigate the effectiveness of cognitive behavioral therapies (CBTs) for anxiety, hardiness, and self-efficacy in female students of Birjand University of Medical Sciences.

Materials And Methods: This was an interventional study. A sample of 30 participants were selected through the available sampling method and randomly assigned into experimental (CBT) and control groups (each group, 15 female student). Read More

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http://dx.doi.org/10.4103/jehp.jehp_327_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432834PMC
February 2019

Engineering Hydrogels beyond a Hydrated Network.

Adv Healthc Mater 2019 Apr 16:e1900038. Epub 2019 Apr 16.

NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU, Paseo de la Universidad 7, 01006, Vitoria-Gasteiz, Spain.

In recent years, many mechanical, physical, chemical, and biochemical features of biomatrices have emerged as important properties to dictate the fates of cells. To construct chemically defined biomaterials to recapitulate various biological niches for both cell biology research and therapeutic utilities, it has become increasingly clear that a simple hydrated polymer network would not be able to provide the complex cues and signaling required for many types of cells. The researchers are facing a growing list of mechanophysical and biochemical properties, while each of them could be an important cellular trigger. Read More

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http://dx.doi.org/10.1002/adhm.201900038DOI Listing
April 2019
4.880 Impact Factor

Life and death of circulating cell-free DNA.

Cancer Biol Ther 2019 Apr 16:1-11. Epub 2019 Apr 16.

a Sharett Institute of Oncology , Hadassah-Hebrew University Medical Center , Jerusalem , Israel.

Tumor-specific, circulating cell-free DNA in liquid biopsies is a promising source of biomarkers for minimally invasive serial monitoring of treatment responses in cancer management. We will review the current understanding of the origin of circulating cell-free DNA and different forms of DNA release (including various types of cell death and active secretion processes) and clearance routes. The dynamics of extracellular DNA in blood during therapy and the role of circulating DNA in pathophysiological processes (tumor-associated inflammation, NETosis, and pre-metastatic niche development) provide insights into the mechanisms that contribute to tumor development and metastases formation. Read More

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http://dx.doi.org/10.1080/15384047.2019.1598759DOI Listing

Comparing Outcomes of Medical Management and Minimally Invasive Surgical Techniques for Lower Urinary Tract Symptoms due to BPH.

Curr Urol Rep 2019 Apr 15;20(6):29. Epub 2019 Apr 15.

Division of Urology, Robert Wood Johnson Medical School, 125 Patterson St, MEB 584A, New Brunswick, NJ, 08901, USA.

Purpose Of Review: Compare outcomes of medical therapy as compared to minimally invasive surgical therapy (MIST) for treatment of bladder outlet obstruction RECENT FINDINGS: Treatment for lower urinary tract symptoms due to benign prostatic hyperplasia (LUTS/BPH) remains largely driven by patient symptomatology with medical therapy or watchful waiting as the first-line management strategies. However, most patients are not adherent to prescribed medical therapies and are hesitant to accept the risks associated with more invasive therapies. Minimally invasive surgical therapies are treatments providing short-term symptom relief superior to medical therapies without the sequela of more invasive procedures. Read More

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http://dx.doi.org/10.1007/s11934-019-0896-2DOI Listing

Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes.

Cells 2019 Apr 3;8(4). Epub 2019 Apr 3.

Department of Stem Cell and Regenerative Biotechnology, Konkuk University, 1 Hwayang-Dong, Gwangin-gu, Seoul 05029, Korea.

Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids, RNA, and DNA. They are derived from endocytic membranes and can transfer signals to recipient cells, thus mediating a novel mechanism of cell-to-cell communication. They are also thought to be involved in cellular waste disposal. Read More

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http://dx.doi.org/10.3390/cells8040307DOI Listing

The effect of antimicrobial photodynamic therapy on infected dentin in primary teeth: A randomized controlled clinical trial protocol.

Medicine (Baltimore) 2019 Apr;98(15):e15110

Nove de Julho University, São Paulo, State of São Paulo, Brazil.

Background: Antimicrobial photodynamic therapy (aPDT) has been used for the treatment of dental caries. Papacarie is a gel composed of papain and chloramine employed for the partial removal of carious tissue, effective against bacteria, however, some studies report that this antibacterial action is not quite so evident. The aim of this study is to evaluate the clinical effect of aPDT on infected dentin in dental caries lesion in primary teeth. Read More

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http://dx.doi.org/10.1097/MD.0000000000015110DOI Listing
April 2019
1 Read

Plasma microRNAs as potential new biomarkers for early detection of early gastric cancer.

World J Gastroenterol 2019 Apr;25(13):1580-1591

The Fifth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.

Background: Early gastric cancer (EGC), compared with advanced gastric cancer (AGC), has a higher 5-year survival rate. However, due to the lack of typical symptoms and the difficulty in diagnosing EGC, no effective biomarkers exist for the detection of EGC, and gastroscopy is the only detection method.

Aim: To provide new biomarkers with high specificity and sensitivity through analyzed the differentially expressed microRNAs (miRNAs) in EGC and AGC and compared them with those in benign gastritis (BG). Read More

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http://dx.doi.org/10.3748/wjg.v25.i13.1580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452233PMC
April 2019
1 Read
2.369 Impact Factor

Occipital Artery to Extradural Vertebral Artery Bypass for Posterior Circulation Ischemia.

Oper Neurosurg (Hagerstown) 2019 May;16(5):527-538

Department of Neurosurgery, Tianjin Huanhu Hospital, Nankai University, Tianjin, China.

Background: Posterior circulation ischemic strokes can have devastating consequences, despite medical therapies. Extracranial-intracranial bypass for the augmentation of flow is a treatment option for selected patients with hemodynamic compromise and recurrent ischemia. However, posterior circulation bypass carries a higher risk and lower patency rate than bypass with anterior circulation. Read More

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http://dx.doi.org/10.1093/ons/opy143DOI Listing

Feasibility of a tailored ERAS programme in octogenarian patients undergoing minimally invasive surgery for colorectal cancer.

Aging Clin Exp Res 2019 Apr 13. Epub 2019 Apr 13.

Department of General Surgery, Sesto San Giovanni Hospital, Milan, Italy.

Background: The enhanced recovery after surgery (ERAS) is nowadays a widely accepted multimodal programme of care in colorectal surgery, but still there is some reluctance in its application to very elderly patients.

Aim: The aim of this study is to investigate short-term outcomes of laparoscopic resection for colorectal cancer in octogenarian patients within the ERAS programme.

Methods: Data on 162 consecutive patients aged ≥ 80 years receiving elective minimally invasive colorectal resections within ERAS programme were collected in a multicentre, retrospective database in the period 2008-2017 in Italy. Read More

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http://dx.doi.org/10.1007/s40520-019-01195-6DOI Listing

Surgical treatment of gastric outlet obstruction from a large trichobezoar: A case report.

Int J Surg Case Rep 2019 Apr 6;57:183-185. Epub 2019 Apr 6.

Department of Minimally Invasive Surgery, Poissy Saint Germain Medical Center, Poissy, France.

Introduction: Bezoars are concretions of foreign indigestible material accumulating in the gastrointestinal tract leading to intraluminal mass formation that impairs the gastrointestinal motility and can lead to gastric obstruction of the small or the large bowel. There are different types of bezoars, named according to the material they are made of. These include phytobezoar, lactobezoar, pharmacobezoar, trichobezoar, and polybezoar. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.04.002DOI Listing
April 2019
2 Reads

ASGE guideline on the role of endoscopy in the evaluation and management of choledocholithiasis.

Gastrointest Endosc 2019 Apr 9. Epub 2019 Apr 9.

Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Center, Aurora, Colorado, USA. Electronic address:

Each year choledocholithiasis results in biliary obstruction, cholangitis, and pancreatitis in a significant number of patients. The primary treatment, ERCP, is minimally invasive but associated with adverse events in 6% to 15%. This American Society for Gastrointestinal Endoscopy (ASGE) Standard of Practice (SOP) Guideline provides evidence-based recommendations for the endoscopic evaluation and treatment of choledocholithiasis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165107183316
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http://dx.doi.org/10.1016/j.gie.2018.10.001DOI Listing
April 2019
1 Read

Evaluation of the Effects of Cultured Bone Marrow Mesenchymal Stem Cell Infusion on Hepatocarcinogenesis in Hepatocarcinogenic Mice With Liver Cirrhosis.

Transplant Proc 2019 Apr;51(3):925-935

Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan; Center for Liver Disease, Yamaguchi University Hospital, Yamaguchi University School of Medicine, Yamaguchi, Japan.

Objectives: Liver transplantation remains the only curative therapy for decompensated liver cirrhosis. However, it has several limitations, and not all patients can receive liver transplants. Therefore, liver regenerative therapy without liver transplantation is considered necessary. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345193049
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http://dx.doi.org/10.1016/j.transproceed.2019.03.011DOI Listing
April 2019
1 Read

Infection after spinal surgery and procedures.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):173-178

Department of Orthopaedics and Trauma Surgery, University Campus Bio-Medico of Rome, Rome, Italy.

Postoperative infections after spinal surgery are a challenging issue, difficult to diagnose and treat, that requires prolonged medical therapy and even surgery. In this paper, we aim to review the current standards in the diagnosis and treatment of post-procedural Spondylodiscitis (SD). We performed a review of the available literature focusing on diagnostic and therapeutic standards of post-procedural SD, both after minimally invasive procedures and open surgery. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17487DOI Listing
April 2019
1 Read

Bioinspired and Biomimetic Nanomedicines.

Acc Chem Res 2019 Apr 12. Epub 2019 Apr 12.

Department of Bioengineering , University of California , Los Angeles , California 90095 , United States.

Nanomedicine development aims to enhance the efficacy, accuracy, safety, and/or compliance of diagnosis and treatment of diseases by leveraging the unique properties of engineered nanomaterials. To this end, a multitude of organic and inorganic nanoparticles have been designed to facilitate drug delivery, sensing, and imaging, some of which are currently in clinical trials or have been approved by the Food and Drug Administration (FDA). In the process, the increasing knowledge in understanding how natural particulates, including cells, pathogens, and organelles, interact with body and cellular systems has spurred efforts to mimic their morphology and functions for developing new generations of nanomedicine formulations. Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.9b00079
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http://dx.doi.org/10.1021/acs.accounts.9b00079DOI Listing
April 2019
6 Reads

The determination of real fluid requirements in laparoscopic resection of pheochromocytoma using minimally invasive hemodynamic monitoring: a prospectively designed trial.

Surg Endosc 2019 Apr 11. Epub 2019 Apr 11.

Division of General Surgery, Section Endocrine Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.

Background: Hemodynamic instability is frequently observed during adrenalectomy for pheochromocytoma (PCC). Guidelines recommend liberal preoperative volume administration. However, it is unclear whether fluid deficiency or vasoplegia causes shifting hemodynamics and whether minimally invasive hemodynamic monitoring with esophageal Doppler (EDM) can help visualize intraoperative changes avoiding volume overload and complications. Read More

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http://dx.doi.org/10.1007/s00464-019-06777-zDOI Listing
April 2019
1 Read

Recent Developments of Nanoparticles In The Treatment Of Photodynamic Therapy For Cervical Cancer.

Authors:
Guan Jiang

Anticancer Agents Med Chem 2019 Apr 11. Epub 2019 Apr 11.

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002. China.

Photodynamic therapy (PDT) is a photoactivation or photosensitization process, wherein the photosensitizer (PS) is activated under appropriate wavelengths. Conventional antitumor therapy for cervical cancer includes surgery, radiotherapy, and chemotherapy. However, these techniques are accompanied by some evident shortcomings. Read More

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http://dx.doi.org/10.2174/1871520619666190411121953DOI Listing
April 2019
4 Reads

Photodynamic therapy guidelines for the management of oral leucoplakia.

Int J Oral Sci 2019 Apr 11;11(2):14. Epub 2019 Apr 11.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, Sichuan, China.

With recent developments in photosensitizers and light delivery systems, topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) has become the fourth alternative therapeutic approach in the management of oral leucoplakia (OLK) due to its minimally invasive nature, efficacy, and low risk of systemic side effects and disfigurement. This report presents step-by-step guidelines for applying topical ALA-PDT in the management of OLK based on both the clinical experience of the authors and a systematic review of the current literature. Studies using protocols with standardized parameters and randomized clinical trials at multiple centres with adequate sample sizes and both interim and long-term follow-ups are needed before universally applicable guidelines can be produced in this field. Read More

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http://www.nature.com/articles/s41368-019-0047-0
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http://dx.doi.org/10.1038/s41368-019-0047-0DOI Listing
April 2019
2 Reads

The Rationale and Efficacy of Primary and Secondary Prevention in Adenocarcinomas of the Upper Gastrointestinal Tract.

Dig Dis 2019 Apr 10:1-13. Epub 2019 Apr 10.

Department of Gastroenterology, Hepatology and Infectious Disease, Otto-von-Guericke University, Magdeburg, Germany.

While the primary risk factor for oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO) is gastro-oesophageal reflux, the infection with Helicobacter pylori (H. pylori) is the dominant risk factor for gastric cancer. Reduction of reflux by dietary measures and proton pump inhibitors has some merits in OAC prevention, and the chemopreventive effect of Aspirin and statins is being widely investigated; however, improved outcome in OAC occurs primarily as the result of secondary prevention. Read More

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http://dx.doi.org/10.1159/000499706DOI Listing
April 2019
1 Read

Photobiomodulation-induced analgesia in experimental temporomandibular disorder involves central inhibition of fractalkine.

Lasers Med Sci 2019 Apr 10. Epub 2019 Apr 10.

Laboratory of Neuromodulation of Experimental Pain, Department of Anatomy, Insitute of Biomedical Sciences, University of São Paulo, Av. Professor Lineu Prestes 2415, ICB III, Cidade Universitária, Sao Paulo, 05508-900, Brazil.

Temporomandibular disorder (TMD) is a collective term that encompasses a set of clinical problems that affect the masticatory muscles, the temporomandibular joint, and associated structures. Despite their high clinical prevalence, the mechanisms of chronic craniofacial muscle pain are not yet well understood. Treatments for TMD pain relief and control should be minimally invasive, reversible, and conservative. Read More

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http://dx.doi.org/10.1007/s10103-019-02785-6DOI Listing

Engineering a naturally-derived adhesive and conductive cardiopatch.

Biomaterials 2019 Jul 21;207:89-101. Epub 2019 Mar 21.

Department of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, CA 90095, USA; Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute (CNSI), University of California - Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA. Electronic address:

Myocardial infarction (MI) leads to a multi-phase reparative process at the site of damaged heart that ultimately results in the formation of non-conductive fibrous scar tissue. Despite the widespread use of electroconductive biomaterials to increase the physiological relevance of bioengineered cardiac tissues in vitro, there are still several limitations associated with engineering biocompatible scaffolds with appropriate mechanical properties and electroconductivity for cardiac tissue regeneration. Here, we introduce highly adhesive fibrous scaffolds engineered by electrospinning of gelatin methacryloyl (GelMA) followed by the conjugation of a choline-based bio-ionic liquid (Bio-IL) to develop conductive and adhesive cardiopatches. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470010PMC
July 2019
1 Read

Combined Treatment of Nonresectable Cholangiocarcinoma Complicated by Obstructive Jaundice.

Photodiagnosis Photodyn Ther 2019 Apr 6. Epub 2019 Apr 6.

Prokhorov General Physics Institute of the Russian Academy of Sciences, Vavilov str., 38, Moscow, 119991, Russia; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Kashirskoye sh., 31, Moscow, 115409, Russia. Electronic address:

Background: The five-year survival rate for successful surgical treatment of cholangiocellular cancer is only 20-40%, and in the case of an unresectable tumor, the life expectancy does not exceed 6 months. These terms decrease with the presence of jaundice due to the spread of the tumor process along the bile ducts, leading to their obstruction. The outcomes of patients with nonresectable bile duct carcinoma complicated by obstructive jaundice have been shown. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.04.006DOI Listing
April 2019
3 Reads

Radiofrequency ablation of liver metastasis: potential impact on immune checkpoint inhibitor therapy.

Eur Radiol 2019 Apr 8. Epub 2019 Apr 8.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

Percutaneous radiofrequency ablation (RFA), a generally accepted alternative therapy for patients with liver metastases, is a minimally invasive approach with a favorable safety profile and a lower rate of major complications. The use of RFA or combined RFA plus resection can produce total tumor clearance in patients with unresectable liver metastases. However, the relatively high rate of local tumor progression has prevented the widespread use of RFA. Read More

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http://dx.doi.org/10.1007/s00330-019-06189-6DOI Listing
April 2019
1 Read

Application of Imaging Technologies in Breast Cancer Detection: A Review Article.

Open Access Maced J Med Sci 2019 Mar 14;7(5):838-848. Epub 2019 Mar 14.

Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran.

One of the techniques utilised in the management of cancer in all stages is multiple biomedical imaging. Imaging as an important part of cancer clinical protocols can provide a variety of information about morphology, structure, metabolism and functions. Application of imaging technics together with other investigative apparatus including in fluids analysis and vitro tissue would help clinical decision-making. Read More

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http://dx.doi.org/10.3889/oamjms.2019.171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447343PMC
March 2019
1 Read

Educational Models for the Re-Establishment of Dental Therapy Education in Canada.

J Dent Educ 2019 Apr 8. Epub 2019 Apr 8.

Susanne Sunell, EdD, is Educational Consultant and Researcher, Omni Educational Group Ltd., Vancouver, Canada; Ann E. Wright, RDH, MBA, is Practice Consultant, ROI Corporation, Mississauga, Canada; Brenda K. Udahl, RDH, MHRD, was Academic Chair of Dental Programs, Saskatchewan Polytechnic, Regina, Canada, at the time of this study; and Paula Benbow, RDH, MPH, was Manager of Health Policy, Canadian Dental Hygienists Association, Ottawa, Canada, at the time of this study.

With the closure of the Canadian dental therapy program in Saskatchewan in 2011 and the increasing need for oral health providers, there have been growing discussions at the national and provincial levels regarding the re-establishment of a provider with dental therapy abilities. The aims of this study were to define models for dental therapy education in Canada and explore how dental therapy abilities could best be integrated into Canadian post-secondary education. In 2017, purposeful sampling was used to invite key informants to participate in a semi-structured interview. Read More

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http://dx.doi.org/10.21815/JDE.019.085DOI Listing
April 2019
3 Reads

Hydrogel Biomaterials for Stem Cell Microencapsulation.

Polymers (Basel) 2018 Sep 6;10(9). Epub 2018 Sep 6.

School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Korea.

Stem cell transplantation has been recognized as a promising strategy to induce the regeneration of injured and diseased tissues and sustain therapeutic molecules for prolonged periods in vivo. However, stem cell-based therapy is often ineffective due to low survival, poor engraftment, and a lack of site-specificity. Hydrogels can offer several advantages as cell delivery vehicles, including cell stabilization and the provision of tissue-like environments with specific cellular signals; however, the administration of bulk hydrogels is still not appropriate to obtain safe and effective outcomes. Read More

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http://dx.doi.org/10.3390/polym10090997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403586PMC
September 2018

Risk of bleeding in patients with continued dual antiplatelet therapy during orthopedic surgery.

Chin Med J (Engl) 2019 Apr;132(8):943-947

Department of Orthopaedics, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Background: To prevent risk of life-threatening stent thrombosis, all patients need to undergo dual antiplatelet therapy (DAPT) for at least 6 weeks to 12 months after stent implantation. If DAPT is continued during noncardiac surgery, there is a risk of severe bleeding at the surgical site. Our study was to assess the risk of bleeding in patients with continued DAPT during orthopedic surgery. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000186DOI Listing

In situ three-dimensional printing for reparative and regenerative therapy.

Biomed Microdevices 2019 Apr 6;21(2):42. Epub 2019 Apr 6.

Center for Minimally Invasive Therapeutics (C-MIT), University of California - Los Angeles, California, Los Angeles, USA.

Three-dimensional (3D) bioprinting is an emerging biofabrication technology, driving many innovations and opening new avenues in regenerative therapeutics. The aim of 3D bioprinting is to fabricate grafts in vitro, which can then be implanted in vivo. However, the tissue culture ex vivo carries safety risks and thereby complicated manufacturing equipment and practice are required for tissues to be implanted in the humans. Read More

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http://dx.doi.org/10.1007/s10544-019-0372-2DOI Listing
April 2019
2.877 Impact Factor

Advances in injectable self-healing biomedical hydrogels.

Acta Biomater 2019 Apr 3. Epub 2019 Apr 3.

Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; MOE Joint International Research Laboratory of CNS Regeneration, Jinan University, Guangzhou 510632, China. Electronic address:

In recent years, implantable biomaterials have attracted significant interest owing to their potentials for use in the therapy of physical defects and traumas. Among the implantable biomaterials, hydrogels have received increasing attention for their tunable structures and good rheological behavior. However, the mechanical failures of traditional gel materials during normal operation remain a serious issue. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.057DOI Listing
April 2019
2 Reads

Oncological outcome following TORS in HPV negative supraglottic carcinoma.

Indian J Cancer 2019 Jan-Mar;56(1):9-14

Department of Surgical Oncology, BLK Super Specialty Hospital, Pusa Road, Delhi, India.

Objective: The aim of this study was to determine the oncological and functional outcomes following transoral robotic surgery (TORS) in human papilloma virus negative supraglottic cancers.

Study Design: A prospective observational study at a tertiary cancer care center, New Delhi, India.

Materials And Methods: From February, 2013 to December, 2015, 45 patients with supraglottic lesions underwent TORS using the da Vinci® surgical system. Read More

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http://dx.doi.org/10.4103/ijc.IJC_172_18DOI Listing
April 2019
6 Reads

Toward Regeneration of the Heart: Bioengineering Strategies for Immunomodulation.

Front Cardiovasc Med 2019 21;6:26. Epub 2019 Mar 21.

National Heart and Lung Institute and BHF Centre for Research Excellence, Imperial College London, London, United Kingdom.

Myocardial Infarction (MI) is the most common cardiovascular disease. An average-sized MI causes the loss of up to 1 billion cardiomyocytes and the adult heart lacks the capacity to replace them. Although post-MI treatment has dramatically improved survival rates over the last few decades, more than 20% of patients affected by MI will subsequently develop heart failure (HF), an incurable condition where the contracting myocardium is transformed into an akinetic, fibrotic scar, unable to meet the body's need for blood supply. Read More

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http://dx.doi.org/10.3389/fcvm.2019.00026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437044PMC
March 2019
1 Read

Uterine-preserving pelvic organ prolapse surgery using the UPHOLD LITE vaginal support system: The outcomes of 291 patients.

Medicine (Baltimore) 2019 Apr;98(14):e15086

Department of Obstetrics and Gynecology.

This article aims to evaluate the safety and outcome of women with pelvic organ prolapse (POP) treated by a minimally invasive bilateral sacrospinous hysteropexy (UPHOLD LITE Vaginal Support System, Boston Scientific) without concomittent anti-incontinence surgery.This retrospective study was conducted between 2014 and 2016. Evaluated items included surgical parameter and postoperative outcome. Read More

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http://dx.doi.org/10.1097/MD.0000000000015086DOI Listing
April 2019
1 Read

Safe and effective percutaneous ethanol injection therapy of 200 thyroid cysts.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2019 Mar 29. Epub 2019 Mar 29.

Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology.

Introduction: Ultrasound-guided percutaneous ethanol injection therapy (US-PEIT) is a minimally invasive procedure that may be performed as an alternative to surgery for the treatment of recurrent symptomatic thyroid cysts for which simple aspiration failed. The present study aimed at assessing US-PEIT in a large cohort of patients, identifying factors influencing treatment outcome.

Methods: Retrospective analysis of 193 patients with 200 thyroid cysts who underwent US-PEIT in 2004-2018. Read More

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http://biomed.papers.upol.cz/doi/10.5507/bp.2019.007.html
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http://dx.doi.org/10.5507/bp.2019.007DOI Listing
March 2019
2 Reads

Robotic intracorporeal ileal conduit: Technical aspects.

Arch Esp Urol 2019 04;72(3):299-308

Catherine & Joseph Aresty Department of Urology. USC Institute of Urology and the Keck School of Medicine. University of Southern California. Los Angeles. CA. USA.

Objective: To present a review of the technical aspects of robotic intracorporeal ileal conduit  (IC) reconstruction after robot assisted radical cystectomy (RARC). METHODS: A non-systematic review is performed in order  to summarize technical aspects on robot assisted ileal conduit procedure following radical cystectomy in patients with muscle invasive bladder cancer.  RESULTS: Radical cystectomy with pelvic lymph node dissection and urinary diversion is the gold-standard therapy for localized muscle-invasive bladder cancer. Read More

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April 2019
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Salvage robot-assisted radical prostatectomy following failed local treatments.

Arch Esp Urol 2019 04;72(3):277-282

Lyx Institute of Urology. Madrid. Spain. University Hospital Puerta de Hierro-Majadahonda. Madrid. Spain.

Prostate cancer represents the most commonly diagnosed cancer in men and is the second-leading cause of cancer related death in the United States. Primary treatment for prostate cancer includes radiotherapy or ablative procedures such as cryotherapy, and high-intensity focused ultrasound (HIFU). Unfortunately, a large proportion of these patients, especially with high risk features, may experience disease recurrence within 10 years. Read More

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April 2019
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Treatment of thyroid nodules with radiofrequency: a 1-year follow-up experience.

J Ultrasound 2019 Apr 3. Epub 2019 Apr 3.

Department of Endocrinology, Azienda Ospedaliera San Giovanni Addolorata, Rome, Italy.

Purpose: The aim of this study is to assess the effectiveness and safety of radiofrequency ablation (RFA) in debulking benign solid thyroid nodules.

Materials And Methods: This is a retrospective review of 77 patients with predominantly solid thyroid nodules treated with RFA in a single center between 2013 and 2016. All patients declined or were not eligible for surgery. Read More

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http://dx.doi.org/10.1007/s40477-019-00375-4DOI Listing
April 2019
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A randomized 500-subject open-label phase 3 clinical trial of minimally invasive surgery plus alteplase in intracerebral hemorrhage evacuation (MISTIE III).

Int J Stroke 2019 Apr 3:1747493019839280. Epub 2019 Apr 3.

2 Division of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD, USA.

Rationale And Hypothesis: Surgical removal of spontaneous intracerebral hemorrhage may reduce secondary destruction of brain tissue. However, large surgical trials of craniotomy have not demonstrated definitive improvement in clinical outcomes. Minimally invasive surgery may limit surgical tissue injury, and recent evidence supports testing these approaches in large clinical trials. Read More

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http://journals.sagepub.com/doi/10.1177/1747493019839280
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http://dx.doi.org/10.1177/1747493019839280DOI Listing
April 2019
3 Reads

Evolution of Spinal Endoscopic Surgery.

Neurospine 2019 Mar 31;16(1):6-14. Epub 2019 Mar 31.

Department of Neurosurgery, Nanoori Incheon Hospital, Incheon, Korea.

Innovations in the development of endoscopic spinal surgery were classified into different generations and reviewed. Future developments and directions for endoscopic spinal surgery were discussed. Surgical therapy for spinal disease has been gradually changing from traditional open surgery to minimally invasive spinal surgery. Read More

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http://dx.doi.org/10.14245/ns.1836322.161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449828PMC
March 2019
1 Read

A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth.

ACS Nano 2019 Apr 3. Epub 2019 Apr 3.

Department of Bioengineering , University of California , Los Angeles , California 90095 , United States.

Activating hair follicle stem cells (HFSCs) to promote hair follicle regrowth holds promise for hair loss therapy, while challenges still remain to develop a scenario that enables enhanced therapeutic efficiency and easy administration. Here we describe a detachable microneedle patch-mediated drug delivery system, mainly made from hair-derived keratin, for sustained delivery of HFSC activators. It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model. Read More

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http://dx.doi.org/10.1021/acsnano.8b09573DOI Listing
April 2019
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A low inflammatory, Langerhans cell-targeted microprojection patch to deliver ovalbumin to the epidermis of mouse skin.

J Control Release 2019 Mar 30. Epub 2019 Mar 30.

The Delivery of Drugs and Genes Group (D(2)G(2)), Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St. Lucia, QL 4072, Australia. Electronic address:

In a low inflammatory skin environment, Langerhans cells (LCs) - but not dermal dendritic cells (dDCs) - contribute to the pivotal process of tolerance induction. Thus LCs are a target for specific-tolerance therapies. LCs reside just below the stratum corneum, within the skin's viable epidermis. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.027DOI Listing
March 2019
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Surgical interventions for the treatment of sacrococcygeal pilonidal sinus disease in children: A systematic review and meta-analysis.

J Pediatr Surg 2019 Mar 16. Epub 2019 Mar 16.

Department of General Surgery, Royal Derby Hospital, Derby, UK DE22 3NE; Department of Surgery, Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Derby, UK DE22 2DT.

Background: Pilonidal sinus disease (PNS) is not uncommon in children. Controversy remains over the best treatment and there is limited evidence. This systematic review and meta-analysis aims to establish which techniques have the best outcomes in children. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.02.058DOI Listing

Template-based temporomandibular joint puncturing and access in minimally invasive TMJ surgery (MITMJS) - a technical note and first clinical results.

Head Face Med 2019 Apr 2;15(1):10. Epub 2019 Apr 2.

Department of Oral and Maxillofacial Plastic Surgery, Helios Vogtlandklinikum Plauen, Roentgenstr. 2, 08529, Plauen, Germany.

Background: Minimally invasive temporomandibular joint surgery (MITMJS) is an option for patients suffering from severe internal derangement or adhesions. To improve TMJ access, a workflow to create surgical templates is introduced.

Methods: A workflow to generate a dividable patient specific template based on CBCT and optical scanning to access the joint is introduced. Read More

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http://dx.doi.org/10.1186/s13005-019-0194-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444874PMC
April 2019
4 Reads

[CAD/CAM Revolution in Craniofacial Reconstruction].

Praxis (Bern 1994) 2019 ;108(5):321-328

1 Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Universitätsspital Zürich.

CAD/CAM Revolution in Craniofacial Reconstruction Abstract. The face is an important part of the personality and at the same time fulfils a variety of tasks. Aesthetics and function form a unique unit. Read More

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http://dx.doi.org/10.1024/1661-8157/a003185DOI Listing
January 2019
2 Reads