99,778 results match your criteria Minimally Invasive Neurosurgery [Journal]


[The Rezūm system in the treatment of male lower urinary tract symptoms (LUTSs) due to benign prostatic obstruction (BPO)].

Aktuelle Urol 2018 Dec 6;49(6):519-524. Epub 2018 Dec 6.

Spital Thurgau AG, Urologie, Frauenfeld.

The classical algorithm of the management of male lower urinary tract symptoms (LUTSs) due to benign prostatic hyperplasia (BPH) includes a surgical approach in case pharmacological therapy has failed. Emerging minimally-invasive treatments (MITs) offer potential for rapid symptomatic relief, reducing the morbidity of invasive BPH surgery. Convective interstitial radiofrequency water vapour thermal ablation of the prostate with the Rezūm system is a novel MIT for the treatment of bothersome moderate-to-severe lower urinary tract symptoms associated with BPH. Read More

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December 2018
8 Reads

[The UroLift® system for treatment of the benign prostatic syndrome (BPS)].

Aktuelle Urol 2018 Dec 6;49(6):515-518. Epub 2018 Dec 6.

Klinikum Großhadern/Innenstadt, Ludwig-Maximilians-Universität München, Urologische Klinik und Poliklinik, München.

Minimally-invasive treatment options for patients with LUTS due to benign prostatic obstruction (BPO) become more and more important because they provide equal long-term efficacy compared with the reference method TURP, while having a more favourable safety profile. There are promising results for PUL (Prostatic Urethral Lift - UroLift) with low complication rates. UroLift is clearly superior regarding the preservation of sexual functions without impairment of ejaculatory function. Read More

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December 2018
5 Reads

miR-122 Targets X-Linked Inhibitor of Apoptosis Protein to Sensitize Oxaliplatin-Resistant Colorectal Cancer Cells to Oxaliplatin-Mediated Cytotoxicity.

Cell Physiol Biochem 2018 Dec 6;51(5):2148-2159. Epub 2018 Dec 6.

Minimally Invasive Treatment Center, Fudan University Shanghai Cancer Center, Shanghai,

Background/aims: Although oxaliplatin is one of the most effective chemotherapeutic drugs used to treat colorectal cancer (CRC), long-term administration usually induces acquired drug resistance during the course of treatment. Thus, there is an urgent need to explore novel strategies to improve the efficiency of cancer therapy. The aim of this study was to explore the effect of microRNA-122 (miR-122) on reversing oxaliplatin resistance in CRC. Read More

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December 2018
2 Reads

β-Elemene Inhibits Human Sperm Function by Affecting Sperm Vitality and Intracellular Calcium.

Cell Physiol Biochem 2018 Dec 6;51(5):2019-2029. Epub 2018 Dec 6.

State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-Sen University, Guangzhou,

Background/aims: β-Elemene is a bioactive sesquiterpene compound that exhibits a potent anti-tumor effect and is used in various clinical applications. However, little is known about its effect on the male reproductive system. The objective of this study was to investigate the in vitro actions of β-elemene on human sperm function and elucidate the underlying mechanism. Read More

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December 2018
2 Reads

Extent of Lymphadenectomy and Postoperative Major Complications Among Women with Endometrial Cancer Treated with Minimally Invasive Surgery.

Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.

Northwestern University, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Chicago, IL, USA; Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL; Center for Healthcare Studies, Institute for Public Health in Medicine, Chicago, IL.

Background: In patients with endometrial cancer sentinel lymphadenectomy is used to accurately prognosticate extent of disease and has been proposed as a method to decrease the incidence of medical and surgical complications associated with more extensive lymphadenectomy. It is unknown if patients who undergo traditional lymphadenectomy experience major postoperative complications at the same rates as those who undergo sentinel lymphadenectomy or those who do not undergo lymphadenectomy.

Objective: To compare the incidence of major postoperative complications among endometrial cancer patients undergoing total laparoscopic hysterectomy with traditional lymphadenectomy versus sentinel or no lymphadenectomy. Read More

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December 2018
2 Reads

[Infrapectineal plate for repair with minimal invasion of quadrilateral blade acetabular fractures: description new implant and paramedial access].

Acta Ortop Mex 2018 May-Jun;32(3):118-125

Instituto de Astronomía de la Universidad Nacional Autónoma de México.

Introduction: Quadrilateral plate fractures are the most difficult to reduce and fix. Different techniques have been developed for quadrilateral plate osteosynthesis. The objective of this work was to create an implant and a novel approach to simplify and improve acetabular fracture osteosynthesis. Read More

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December 2018

Evaluation of the effectiveness of laser photoselective vaporization of the prostate in the treatment of patients with benign prostatic hyperplasia.

Folia Med Cracov 2018 ;58(3):23-33

Urology Department Military Institute of Medicine, Szaserów 128, Warszawa, Poland.

Introduction: The prolongation of the life of men results in the growing number of people suffering from benign prostatic hyperplasia (BPH). In 2010, BPH concerned more than 200 million men in the whole world, which at that time made up 6% of the population of men at large. Currently, the population of men in the world amounts about three billion six hundred million. Read More

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January 2018
1 Read

Short communication: Targeted proteomic analysis detects acute T cell-mediated kidney allograft rejection in belatacept-treated patients.

Ther Drug Monit 2018 Dec 4. Epub 2018 Dec 4.

Departments of Internal Medicine, Division of Nephrology and Transplantation and.

Background: There is an unmet need for reliable minimally invasive diagnostic biomarkers for immunological allograft monitoring and for the detection of acute kidney transplant rejection. Here, targeted proteomic analysis was applied to compare 92 proteins in sera of belatacept-treated patients who had biopsy-proven, acute T cell-mediated rejection (aTCMR) with patients without aTCMR.

Methods: Proximity extension immunoassay (PEA) was used to measure 92 inflammation-related protein concentrations in the pre-rejection and rejection sera of 11 patients with aTCMR and 9 patients without aTCMR. Read More

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December 2018

Chinese Expert Consensus Workshop Report: Guideline for permanent iodine-125 seed implantation of primary and metastatic lung tumors.

Thorac Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Interventional Medicine, The Second Hospital of Shandong University, Jinan, China.

Surgery remains the first choice of cure for early stage lung cancer. However, many patients are diagnosed at advanced stage, and thus miss the opportunity to undergo surgery. As such patients derive limited benefits from chemotherapy or radiotherapy, alternatives focusing on local control have emerged, including iodine-125 seed implantation. Read More

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December 2018

In silico error correction improves cfDNA mutation calling.

Bioinformatics 2018 Dec 6. Epub 2018 Dec 6.

Medical Research Council Manchester Single Cell Research Centre, University of Manchester, Alderley Park, Manchester, UK.

Motivation: Circulating-free DNA (cfDNA) profiling by sequencing is an important minimally invasive protocol for monitoring the mutation profile of solid tumours in cancer patients. Since the concentration of available cfDNA is limited, sample library generation relies on multiple rounds of PCR amplification, during which the accumulation of errors results in reduced sensitivity and lower accuracy.

Results: We present PCR Error Correction (PEC), an algorithm to identify and correct errors in short read sequencing data. Read More

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December 2018
1 Read

A minimally-invasive hybrid approach for cardiac resynchronization of the systemic right ventricle.

Pacing Clin Electrophysiol 2018 Dec 6. Epub 2018 Dec 6.

University of California Los Angeles, Department of Cardiothoracic Surgery, UCLA Medical Center, Los Angeles, CA.

Background: Patients with systemic right ventricles (RV) often develop progressive heart failure and may benefit from cardiac resynchronization therapy (CRT), however the optimal strategy for CRT has not been defined.

Methods: A retrospective review of all patients with systemic RV failure undergoing a hybrid transcatheter-surgical approach was performed. Procedural technique and outcomes are reported. Read More

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December 2018

Predictive significance of serum inhibin B on testicular haploid gamete retrieval outcomes in nonobstructive azoospermic men.

Asian J Androl 2018 Nov 30. Epub 2018 Nov 30.

Center for Reproductive Medicine, Shandong University, Jinan 250001, China.

The purpose of this study was to determine the diagnostic accuracy of serum inhibin B (INHB) as a predictor of the retrieval outcome of testicular haploid gametes (spermatids and testicular spermatozoa) in nonobstructive azoospermic men. Serum hormone levels, testicular volume, and histological evaluation were performed in 403 Chinese nonobstructive azoospermic men. Testicular haploid gamete was successfully retrieved in 213 of 403 patients (52. Read More

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November 2018

Preliminary experience of the use of high-resolution skin ultrasound for the evaluation of extrathyroideal manifestations of Graves' disease and response to UVA-1 phototherapy.

Photodermatol Photoimmunol Photomed 2018 Dec 6. Epub 2018 Dec 6.

Dermatology Unit, Department of Medical, Surgical and Neuro-Sciences, University of Siena, Siena, Italy.

Graves' orbitopathy (GO) and pre-tibial mixedema (PTM) are autoimmune manifestation sharing the same etiology and histopathology, a chronic course and a frustrating treatment. Current management include topical and systemic corticosteroid as first line therapy, whereas cyclosporine, surgery and orbital radiotherapy are indicated for severe GO with variable results and mostly temporary remissions. In particular, keratopath and photophobia, due to exophthalmos and eyelid retraction, impaired eye mobility and diplopia due to the compression of optic nerve and extra-ocular muscles are usually minimally modified, as well as leg plaques/nodules and lymphoedema. Read More

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December 2018
2 Reads

European Surveillance System on Contact Allergies (ESSCA): contact allergies in relation to body sites in patients with allergic contact dermatitis.

Contact Dermatitis 2018 Dec 5. Epub 2018 Dec 5.

University of Groningen, University Medical Center Groningen, Department of Dermatology, The Netherlands.

Background: Analyses of the European Surveillance System on Contact Allergies (ESSCA) database have focused primarily on prevalence of contact allergies to the European baseline series; overall and in subgroups of patients. However, affected body sites have hitherto not been addressed.

Objective: To determine prevalence of contact allergies for distinct body sites in patients with allergic contact dermatitis (ACD). Read More

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December 2018
1 Read

Minimally invasive plate osteosynthesis (MIPO) in AO/OTA type B displaced clavicle fractures.

Musculoskelet Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Orthopaedics, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, India.

Introduction: Open reduction and plate fixation is known to reduce chances of malunion and symptomatic nonunion in displaced middle-third clavicle fractures. However, this treatment modality is also associated with several complications, such as hardware irritation, numbness around the surgical scar, infection, nonunion and implant failure. The minimally invasive plate osteosynthesis (MIPO) technique may reduce these complications. Read More

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December 2018

Laparoscopic and robotic-assisted repair of retrocaval ureter in children: a multi-institutional comparative study with open repair.

World J Urol 2018 Dec 5. Epub 2018 Dec 5.

Division of Pediatric Surgery, "Federico II" University of Naples, Via Pansini 5, 80131, Naples, Italy.

Purpose: This retrospective study aimed to report a multi-institutional experience with laparoscopic and robotic-assisted repair of retrocaval ureter in children and to compare outcome of minimally invasive surgery (MIS) with open repair.

Methods: The records of all children, who underwent MIS and open repair of retrocaval ureters in six international pediatric urology units over a 5-year period, were retrospectively collected. Data were grouped according to the operative approach: a laparoscopic group (G1) included five patients, a robotic-assisted group (G2) included four patients, and an open group (G3) included three patients. Read More

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December 2018
1 Read

[Combined XEN and Baerveldt implant-principles and management of complications].

Ophthalmologe 2018 Dec 5. Epub 2018 Dec 5.

Augenklinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstr. 1, 55116, Mainz, Deutschland.

The treatment of congenital glaucoma requires special expertise and often novel surgical approaches. The combined use of a XEN and a Baerveldt implant is an alternative to conventional tube implants and may be less harmful for long-term corneal endothelial damage. If this technique does not provide sufficient long-term control of intraorbital pressure (IOP), a direct implantation of the Baerveldt tube can be easily performed in a second intervention. Read More

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December 2018

Catheter-Directed Fenestration for Branch Vessel Reconnection in Aortic Dissection Using a Novel Diamond-Tipped Chronic Total Occlusion Drilling Device: A Technical Report.

Cardiovasc Intervent Radiol 2018 Dec 5. Epub 2018 Dec 5.

Interventional Radiology Service - Department of Radiology, Austin Hospital, Heidelberg, Melbourne, VIC, 3084, Australia.

Purpose: Aortic dissection is a complex condition with high morbidity and mortality. Endovascular treatments including percutaneous fenestration can be used to manage branch vessel ischaemia or risk of aortic rupture. A variety of techniques for aortic fenestration have been described. Read More

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December 2018

Efficacy of Alveolar Ridge Preservation after Maxillary Molar Extraction in Reducing Crestal Bone Resorption and Sinus Pneumatization: A Multicenter Prospective Case-Control Study.

Biomed Res Int 2018 4;2018:9352130. Epub 2018 Nov 4.

Department of Medical, Surgical and Health Sciences, University of Trieste, Italy.

Aim: To evaluate, with three-dimensional analysis, the effectiveness of alveolar ridge preservation (ARP) after maxillary molar extraction in reducing alveolar bone resorption and maxillary sinus pneumatization when compared to unassisted socket healing.

Methods: Patients were included in the study following inclusion criteria and underwent minimally traumatic maxillary molar extraction followed by ARP using synthetic nanohydroxyapatite (Fisiograft Bone, Ghimas, Italy) (test group) or unassisted socket healing (control group). Cone-beam computerized tomographies (CBCT) were performed immediately after tooth extraction (T0) and 6 months postoperatively (T1). Read More

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November 2018

Recent advances in the management of nasopharyngeal carcinoma.

F1000Res 2018 21;7. Epub 2018 Nov 21.

Department of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Over the last few years, certain areas in the management nasopharyngeal carcinoma (NPC) that have an impact on the care of these patients have evolved, particularly with regard to liquid biopsies, minimally invasive surgery, and advances in chemotherapy and immunotherapy. Beyond its proven role in the diagnostics, surveillance, and treatment of NPC, liquid biopsy with plasma Epstein-Barr virus DNA in the screening of high-risk populations for NPC is strongly supported by recent evidence. Surgery of the nasopharynx is reserved for locally recurrent NPC, and in recent years there have been great strides in minimally invasive techniques with survival rates similar to those of open techniques in treating NPC. Read More

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November 2018
1 Read

Outcomes of Laparoscopic Total Gastrectomy for Elderly Gastric Cancer Patients.

J Cancer 2018 22;9(23):4398-4403. Epub 2018 Oct 22.

Department of Gastrointestinal Surgery, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130000, People's Republic of China.

The purpose of this study was to compare the short- and long-term outcomes after laparoscopic total gastrectomy (LTG) between elderly and non-elderly patients with gastric cancer. A retrospective analysis was performed using clinical and follow-up data from 168 patients treated with LTG for gastric cancer at our institution from January 2010 to December 2017. For this study, the short- and long-term outcomes (including tumor recurrence rate, disease-free survival rate, and overall survival rate) were compared between the elderly group (≥70 years) and non-elderly group (<70 years). Read More

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October 2018

Promotion of Cell Proliferation through Inhibition of Cell Autophagy Signalling Pathway by Rab3IP is Restrained by MicroRNA-532-3p in Gastric Cancer.

J Cancer 2018 22;9(23):4363-4373. Epub 2018 Oct 22.

Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangdong Provincial Engineering Technology Research Center of Minimally Invasive Surgery, Guangzhou 510515, China.

RAB3A-interacting protein (Rab3IP) is known to be involved in cancer; however, its function during the proliferation of gastric cancer (GC) cells remains unknown. Therefore, this study aimed to explore the potential function of Rab3IP in GC. The expression of Rab3IP and its clinical pathology value were determined by quantitative real-time PCR and immunohistochemistry. Read More

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October 2018

Minimally invasive thoracic surgery for empyema.

Breathe (Sheff) 2018 Dec;14(4):302-310

Clinic for Thoracic Surgery, University Hospital Basel, Basel, Switzerland.

The widely accepted and still increasing use of video-assisted thoracic surgery (VATS) in pleuro-pulmonary pathology imposes the need to deal with two major pitfalls: the first is to avoid its unselective use, while the second relates to inappropriate rejection of VATS on the basis of "insufficient radicality". Unlike a quite established role of VATS in lung cancer patients, in patients with pleural empyema, the role of VATS is less clearly defined. The current evidence about VATS in patients with pleural empyema could be summarised as follows: VATS is accepted as a useful treatment option for fibrinopurulent empyema, but the treatment failure rate increases with the increasing proportion of stage III empyema, necessitating further surgical options like thoracotomy and decortication. Read More

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December 2018

Behavioral and Resting State Functional Connectivity Effects of High Frequency rTMS on Disorders of Consciousness: A Sham-Controlled Study.

Front Neurol 2018 21;9:982. Epub 2018 Nov 21.

Department of Neurology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

A combined approach of behavioral characteristics and network properties was applied to explore the effect of repetitive transcranial magnetic stimulation (rTMS) on disorders of consciousness (DOC) and to observe changes in brain network connections before and after the stimulation. A total of 7 DOC patients and 11 healthy controls were enrolled. The study was designed as a randomized, sham-controlled study. Read More

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November 2018
1 Read

Transarterial chemoembolization with radiofrequency ablation versus hepatectomy in hepatocellular carcinoma beyond the Milan criteria: a retrospective study.

Cancer Manag Res 2018 8;10:5545-5552. Epub 2018 Nov 8.

Minimally Invasive and Interventional Department, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China,

Purpose: To compare the efficacies of transarterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) with hepatectomy. Prognostic factors for the patient groups were analyzed.

Patients And Methods: Data of 314 newly diagnosed cases of hepatocellular carcinoma beyond the Milan criteria were studied from January 2012 to December 2013 in our hospital. Read More

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November 2018

Reinforcement of calcium phosphate cement using alkaline-treated silk fibroin.

Int J Nanomedicine 2018 9;13:7183-7193. Epub 2018 Nov 9.

Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China,

Background: Bone cement plays an important role in the treatment of osteoporotic vertebral compression fractures. Calcium phosphate cement (CPC) is a potential alternative to poly(methyl methacrylate), currently the gold standard of bone cements. However, the poor mechanical properties of CPCs limit their clinical applications. Read More

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November 2018
1 Read

Cryopreservation of primary B cells minimally influences their signaling responses.

Sci Rep 2018 Dec 5;8(1):17651. Epub 2018 Dec 5.

Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway.

Phospho flow is a powerful approach to detect cell signaling aberrations, identify biomarkers and assess pharmacodynamics, and can be performed using cryopreserved samples. The effects of cryopreservation on signaling responses and the reproducibility of phospho flow measurements are however unknown in many cell systems. Here, B lymphocytes were isolated from healthy donors and patients with the B cell malignancy chronic lymphocytic leukemia and analyzed by phospho flow using phospho-specific antibodies targeting 20 different protein epitopes. Read More

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December 2018

Assessment of Test Performance and Potential for Environmental Contamination Associated with a Point-of-Care Molecular Assay for Group A in an End-User Setting.

J Clin Microbiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905.

Although FDA-approved and CLIA-waived point-of-care (POC) molecular systems are being implemented in routine clinical practice, instrument reliability, test performance in the hands of end-users, and the potential for environmental contamination resulting from use of POC molecular systems have not been extensively evaluated. We performed a prospective evaluation of the Roche cobas Liat group A streptococcus (GAS) assay compared to routine real-time PCR. We evaluated test accuracy, instrument failure rate, and monitored for environmental contamination when testing was performed by minimally trained end users in an Express Care Clinic environment. Read More

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December 2018

Minimally invasive McKeown's vs open oesophagectomy for cancer: A meta-analysis.

Eur J Surg Oncol 2018 Nov 24. Epub 2018 Nov 24.

Division of Surgery, The Canberra Hospital, Garran, ACT, Australia. Electronic address:

Background: The effectiveness of minimally invasive oesophagectomy (MIO) compared to open oesophagectomy (OO) remains controversial. Various techniques for performing MIO are currently used, but the evidence for them is lacking. The objective of this meta-analysis was to compare the safety, efficacy and oncological outcomes of McKeown's minimally invasive oesophagectomy (McKeown's-MIO) to OO. Read More

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November 2018

Folded large-bore central catheter in the right internal jugular vein as shown by ultrasound: a case report.

J Int Med Res 2018 Dec 6:300060518813514. Epub 2018 Dec 6.

1 Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital, Gwangju, South Korea.

Central venous catheters are used for various purposes in the operating room. Generally, the use of ultrasound to insert a central venous catheter is rapid and minimally complicated. An advanced venous access (AVA) catheter is used to gain access to the pulmonary artery and facilitate fluid resuscitation through the internal jugular vein. Read More

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December 2018

Preoperative Administration of Olive Oil Reduces Chylothorax after Minimally Invasive Esophagectomy.

Ann Thorac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Surgical Oncology, Shantou Central Hospital, China. Electronic address:

Background: Chylothorax after esophagectomy is uncommon but potentially fatal. We performed a retrospective study to assess the effect of olive oil administered orally before surgery on reducing chylothorax in patients who underwent minimal invasive esophagectomy.

Methods: Between May 2013 and December 2016, patients with esophageal squamous cell cancer who underwent minimal invasive esophagectomy were screened. Read More

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November 2018

Asymmetric dimethylation at histone H3 arginine 2 by PRMT6 in gastric cancer progression.

Carcinogenesis 2018 Dec 3. Epub 2018 Dec 3.

Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

Histone modification plays important molecular roles in development and progression of cancers. Dysregulation of histone H3 arginine (R) methylation is still unknown in primary cancer, including gastric cancer (GC). Although PRMT6 contributes to asymmetric dimethylation at H3R2 (H3R2me2as) in cancer cells, its molecular functions are poorly understood in GC. Read More

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December 2018
1 Read

Anatomic Landmarks in Transoral Oropharyngeal Surgery.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Otolaryngology Section, Head and Neck Surgery, Hospital Universitari Germans Trias i Pujol.

Introduction: Minimally invasive transoral surgery for oropharyngeal cancer is a challenge for head and neck surgeons because of the inside-out anatomic presentation and the confined workspace. This study was performed to describe the main neurovascular and muscular landmarks in a transoral approach. The authors propose an anatomic stratification for this surgery. Read More

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November 2018

Tubular Transforaminal Lumbar Interbody Fusion is Superior to a Midline Incision With Cortical Screws for a Minimally Invasive Interbody Fusion.

Clin Spine Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL.

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November 2018
1 Read

Biomechanical comparison of three kinds of fixation in fracture-dislocation of the sacroiliac joint.

Technol Health Care 2018 Nov 15. Epub 2018 Nov 15.

Background: Although there are several different kinds of fixation techniques for the sacroiliac fracture-dislocation, the treatment remains a challenge for orthopedic surgeons.

Objective: The purpose of this study was to compare the stability of sacroiliac fracture-dislocation fixed with two iliosacral (IS) screws, tension band plate (TBP), and minimally invasive adjustable plate (MIAP).

Methods: Five human cadavers (L4-pelvic-femora) were used to compare biomechanical stability. Read More

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November 2018

Clinical advantages of robotic gastrectomy for clinical stage I/II gastric cancer: a multi-institutional prospective single-arm study.

Gastric Cancer 2018 Dec 3. Epub 2018 Dec 3.

Division of Gastric Surgery, Shizuoka Cancer Center, Shizuoka, Japan.

Background: Robotic gastrectomy (RG) for gastric cancer (GC) has been increasingly performed for a decade; however, evidence for its use as a standard treatment has not yet been established. The present study aimed to determine the safety, feasibility, and effectiveness of RG for GC.

Methods: This multi-institutional, single-arm prospective study, which included 330 patients from 15 institutions, was designed to compare morbidity rate of RG with that of a historical control (conventional laparoscopic gastrectomy, LG). Read More

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December 2018
1 Read

Quad Screen Test, A Multiplexed Biomarker Assay for Prenatal Screening to Assess Birth Defects: The Columbia University Experience Using the Beckman Access2 Immunoassay Analyzer and Benetech PRA.

Methods Mol Biol 2019 ;1885:297-307

Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.

In the prenatal quad screen, the levels of four analytes in maternal serum are used to calculate the risk of serious birth defects. The Beckman Access2 Immunoassay System is an automated analyzer that enables rapid measurement of alpha-fetoprotein, unconjugated estriol, human chorionic gonadotropin, and dimeric inhibin A. The Benetech PRA software package is used to convert maternal serum analyte concentrations to multiples of the median (MoM) and calculates the risks of particular birth defects. Read More

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January 2019

Minimally Invasive Treatment for Benign Prostatic Hyperplasia: Economic Evaluation from a Standardized Hospital Case Costing System.

Cardiovasc Intervent Radiol 2018 Nov 30. Epub 2018 Nov 30.

Division of Vascular and Interventional Radiology, Department of Medical Imaging, Toronto General Hospital, University Health Network, University of Toronto, 585 University Ave, Toronto, ON, M5G 2N2, Canada.

Purpose: Minimally invasive alternatives to transurethral resection of the prostate (TURP) such as prostate arterial embolization (PAE) and photoselective vaporization of the prostate (PVP) are being explored as adjuncts in the care of patients with benign prostatic hyperplasia. However, there are conflicting reports of the costs of these procedures. The purpose of this study was to compare the direct and indirect hospital costs of TURP, PAE and PVP. Read More

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November 2018
1 Read

Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).

Breast Cancer Res Treat 2018 Nov 30. Epub 2018 Nov 30.

Institute of Pathology and Molecular Pathology, University Hospital Zurich, Switzerland Schmelzbergstrasse 12., 8091, Zurich, Switzerland.

Purpose: The second International Consensus Conference on B3 lesions was held in Zurich, Switzerland, in March 2018, organized by the International Breast Ultrasound School to re-evaluate the consensus recommendations.

Methods: This study (1) evaluated how management recommendations of the first Zurich Consensus Conference of 2016 on B3 lesions had influenced daily practice and (2) reviewed current literature towards recommendations to biopsy.

Results: In 2018, the consensus recommendations for management of B3 lesions remained almost unchanged: For flat epithelial atypia (FEA), classical lobular neoplasia (LN), papillary lesions (PL) and radial scars (RS) diagnosed on core-needle biopsy (CNB) or vacuum-assisted biopsy (VAB), excision by VAB in preference to open surgery, and for atypical ductal hyperplasia (ADH) and phyllodes tumors (PT) diagnosed at VAB or CNB, first-line open surgical excision (OE) with follow-up surveillance imaging for 5 years. Read More

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November 2018
1 Read

DUSP6 Inhibitor (E/Z)-BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway.

Inflammation 2018 Dec 1. Epub 2018 Dec 1.

School of Stomatology, Dalian Medical University, Dalian, 116044, People's Republic of China.

Macrophages play a fundamental role in human chronic diseases such as rheumatoid arthritis, atherosclerosis, and cancer. In the present study, we demonstrated that dual-specificity phosphatase 6 (DUSP6) was upregulated by lipopolysaccharide (LPS) treatment of macrophages. (E/Z)-BCI hydrochloride (BCI) functions as a small molecule inhibitor of DUSP6, and BCI treatment inhibited DUSP6 expression in LPS-activated macrophages. Read More

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December 2018

Current concepts for lumbar disc herniation.

Int Orthop 2018 Nov 30. Epub 2018 Nov 30.

Orthopaedic and Traumatology Surgery Department (Pr Ch Court), AP-HP Paris, Bicêtre University Hospital, Paris-Sud University ORSAY, 78 Rue du Général Leclerc, 94275, Le Kremlin-Bicêtre, France.

Purpose: To present the pathophysiology, biology, clinical presentation, diagnosis, and current treatment options for lumbar disc herniation.

Methods: A thorough literature search was undertaken in PubMed and Google Scholar to summarize the current knowledge and future perspectives on lumbar disc herniation.

Results: Several changes in the biology of the intervertebral disc are thought to contribute to disc herniation; nevertheless, the exact inciting event leading to disc herniation is yet to be discovered. Read More

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November 2018
1 Read

Minimally invasive esophagectomy for Barrett's adenocarcinoma.

Transl Gastroenterol Hepatol 2018 16;3:77. Epub 2018 Oct 16.

Department of Biomedical Sciences for Health, Division of General Surgery, IRCCS Policlinico San Donato, University of Milan, Italy.

Minimally invasive esophagectomy has become the preferred approach for invasive Barrett's adenocarcinoma because it can speed recovery and enhance patient's quality of life. Multiple minimally invasive surgical techniques have been described during the last two decades. Preoperative staging, anatomy and physiological patient's status, comorbidity, and experience of the surgical team should drive the choice of the surgical approach. Read More

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October 2018

Arthroscopic Superior Capsular Reconstruction With a Minimally Invasive Harvested Fascia Lata Autograft Produces Good Clinical Results.

Orthop J Sports Med 2018 Nov 27;6(11):2325967118808242. Epub 2018 Nov 27.

Instituto de Engenharia de Sistemas e Computadores-Investigação e Desenvolvimento, Lisbon, Portugal.

Background: Painful dysfunctional shoulders with irreparable rotator cuff tears (IRCTs) in active patients are a challenge. Arthroscopic superior capsular reconstruction (ASCR) is a new treatment option originally described using a fascia lata autograft harvested through an open approach. However, concerns about donor site morbidity have discouraged surgeons from using this type of graft. Read More

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November 2018

Single-incision laparoscopic ileostomy is a safe and feasible method of fecal diversion for anastomotic leakage following laparoscopic low anterior resection.

Ann Surg Treat Res 2018 Dec 26;95(6):319-323. Epub 2018 Nov 26.

Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Currently, many operations are performed using the single-incision laparoscopic method. Although there have been recent reports on single-incision laparoscopic ileostomy, none have compared this method to conventional laparoscopic ileostomy. This study aimed to assess the safety and feasibility of single-incision laparoscopic ileostomy for anastomotic leakage following laparoscopic low anterior resections. Read More

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December 2018

Gasless, transaxillary robotic neck dissection: the technique and evidence.

Gland Surg 2018 Oct;7(5):466-472

Department of Surgery, Yonsei University College of Medicine, Seodaemun-gu, Seoul, South Korea.

Robotic neck dissection (ND) for the thyroid cancer with lateral neck metastasis case is one of the emerging surgical techniques, and has been highlighted as minimally invasive surgical technique recently. Gasless, transaxillary robotic approach enabled the surgeon to do meticulous and precise dissection in the complex procedure, such as ND, eventually showed favorable surgical safety and outcomes, as well as superior functional and cosmetic benefits. In this article, the author would like to introduce the detailed techniques and secure evidences for the gasless, transaxillary robotic ND. Read More

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October 2018
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Short-term clinical outcomes and long-term survival of minimally invasive direct coronary artery bypass grafting.

Ann Cardiothorac Surg 2018 Sep;7(5):621-627

Department of Cardiac Surgery, Harefield Hospital, London, UK.

Background: Minimally invasive direct coronary artery bypass (MIDCAB) grafting is regarded as an alternative to conventional coronary artery bypass grafting (CABG) through full sternotomy, particularly for patients with isolated proximal left anterior descending (LAD) artery stenosis deemed unsuitable for percutaneous coronary intervention. However, the technically demanding nature of the procedure and lack of long-term published outcomes have precluded its universal adoption. We report the comparative short-term outcomes and long-term survival of MIDCAB and conventional CABG through full sternotomy for grafting of isolated LAD. Read More

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September 2018

Comparison of minimally invasive direct coronary artery bypass and drug-eluting stents for management of isolated left anterior descending artery disease: a systematic review and meta-analysis of 7,710 patients.

Ann Cardiothorac Surg 2018 Sep;7(5):567-576

Department of Cardiac Surgery, St. George's Hospital, London, UK.

Background: In the contemporary era of drug-eluting stents (DES) the issue of optimal revascularization strategy for patients with isolated disease of the left anterior descending (LAD) artery has gained more significance. We aimed to evaluate the current best evidence on the subject by performing a systematic review and meta-analysis of the studies comparing minimally invasive direct coronary artery bypass (MIDCAB) grafting with DES in patients with isolated LAD disease.

Methods: A literature search was conducted from 1966 through March 2018 using MEDLINE, EMBASE, and other scientific databases to identify relevant articles. Read More

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September 2018

The modified transforaminal endoscopic technique in treating intracanalicular combining foraminal and/or extraforaminal lumbar disc herniations.

Quant Imaging Med Surg 2018 Oct;8(9):936-945

Department of Orthopedics, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.

Background: To develop a modified transforaminal endoscopic spine system (TESSYS) technique for treating intracanalicular combining foraminal and/or extraforaminal lumbar disc herniation (ICFE-LDH), and evaluate the technical efficacy and safety.

Methods: Twenty-three patients with ICFE-LDH underwent the modified TESSYS technique were enrolled. Magnetic resonance imaging (MRI) was used to verify the reduction of herniated disc. Read More

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October 2018
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Outcomes associated with robotic approach to pancreatic resections.

J Gastrointest Oncol 2018 Oct;9(5):936-941

Department of Gastrointestinal Oncology, Sarasota Memorial Hospital, Sarasota, FL, USA.

Minimally invasive techniques have improved post-operative outcomes, however, the majority of pancreatic surgery, known for its complexity, is still performed via open approaches. The development of robotics has improved dexterity which may allow for application in more complex surgeries. We queried a prospectively maintained robotic database to identify patients who underwent robotic pancreatic resection by a single surgeon between 2012 and 2016. Read More

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October 2018
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Esophagectomy from then to now.

J Gastrointest Oncol 2018 Oct;9(5):903-909

Department of Gastrointestinal Oncology, Sarasota Memorial Healthcare System, Sarasota, FL, USA.

We have come a long way from the onset of surgery for esophageal cancer. Surgical resection is pivotal for the long-term survival in patients with locally advanced esophageal cancer. Moreover, advancements in post-operative care and surgical techniques have contributed to reductions in morbidity. Read More

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October 2018
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