8,560 results match your criteria Minimal-Change Disease


Validity and reliability of the 3-meter backward walk test in patients with multiple sclerosis.

Mult Scler Relat Disord 2022 May 4;63:103842. Epub 2022 May 4.

Department of Physiotherapy and Rehabilitation, SANKO University, Faculty of Health Science, Gaziantep, Turkey.

Background: The 3-meter backward walk test (3MBWT) evaluates neuromuscular control, proprioception, protective reflexes, fall risk, and balance. This study aimed to examine the reliability, validity, and minimal detectable change (MDC) of the 3MBWT in patients with Multiple Sclerosis (pwMS).

Methods: 40 pwMS (8 male, 32 female) were included in the study. Read More

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Liquid biopsies for residual disease and recurrence.

Med (N Y) 2021 Dec;2(12):1292-1313

Inivata, Cambridge CB22 3FH, UK; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK; Cancer Research UK Cambridge Centre, Cambridge CB2 0RE, UK. Electronic address:

Detection of minimal residual disease in patients with cancer, who are in complete remission with no cancer cells detectable, has the potential to improve recurrence-free survival through treatment selection. Studies analyzing circulating tumor DNA (ctDNA) in patients with solid tumors suggest the potential to accurately predict and detect relapse, enabling treatment strategies that may improve clinical outcomes. Over the past decade, assays for ctDNA detection in plasma samples have steadily increased in sensitivity and specificity. Read More

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December 2021

Focal segmental glomerulosclerosis: Risk for recurrence and interventions to optimize outcomes following recurrence.

Pediatr Transplant 2022 May 19:e14307. Epub 2022 May 19.

University of Wisconsin Madison, Madison, Wisconsin, USA.

Background: FSGS is a common indication for kidney transplant with a high-risk of posttransplant recurrence.

Methods: In this review, we summarize current knowledge about FSGS recurrence after kidney transplantation, including epidemiology, pretransplant planning, posttransplant management, and investigational treatments.

Results: FSGS recurs in 14%-60% of first transplants, likely associated with a circulating permeability factor. Read More

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A Case of Minimal Change Disease after SARS-CoV-2 Vaccination under the Age of 18.

Avicenna J Med 2022 Jan 10;12(1):31-33. Epub 2022 Mar 10.

Department of Nephrology, American Hospital, Dubai, United Arab Emirates.

This is a care report of a 16-year-old-male who developed de novo minimal change disease following the second dose of the Pfizer vaccine. The patient developed sudden onset edema and 10 kg weight gain. He had nephrotic range proteinuria with normal renal function. Read More

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January 2022

How Whole Slide Imaging and Machine Learning Can Partner with Renal Pathology.

Kidney360 2022 Mar 11;3(3):413-415. Epub 2022 Feb 11.

Division of Anatomic and Molecular Pathology, Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri.

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Explainable Biomarkers for Automated Glomerular and Patient-Level Disease Classification.

Kidney360 2022 Mar 9;3(3):534-545. Epub 2021 Dec 9.

Image Analysis in Medicine Lab (IAMLAB), Department of Electrical, Computer, and Biomedical Engineering, Ryerson University, Toronto, Canada.

Pathologists use multiple microscopy modalities to assess renal biopsy specimens. Besides usual diagnostic features, some changes are too subtle to be properly defined. Computational approaches have the potential to systematically quantitate subvisual clues, provide pathogenetic insight, and link to clinical outcomes. Read More

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Retinal drusen in glomerulonephritis with or without immune deposits suggest systemic complement activation in disease pathogenesis.

Sci Rep 2022 May 17;12(1):8234. Epub 2022 May 17.

University of Melbourne Department of Medicine (Melbourne Health), Parkville, VIC, 3076, Australia.

Retinal drusen are characteristic of macular degeneration and complement activation, but also occur in C3, lupus and IgA nephropathy. This cross-sectional observational study compared drusen counts in different forms of glomerulonephritis. Consecutive individuals with glomerulonephritis attending a general renal or transplant clinic underwent retinal imaging with a non-mydriatic camera. Read More

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Kidney Biopsy Features Most Predictive of Clinical Outcomes in the Spectrum of Minimal Change Disease and Focal Segmental Glomerulosclerosis.

J Am Soc Nephrol 2022 May 17. Epub 2022 May 17.

Department of Pathology, Division of AI and Computational Pathology, and Department of Medicine, Division of Nephrology, Duke University, Durham, North Carolina

Background: Heterogeneity in disease course and treatment response among patients with MCD/FSGS necessitates a granular evaluation of kidney tissue features. This study aimed to identify histologic and ultrastructural descriptors of structural changes most predictive of clinical outcomes in the Nephrotic Syndrome Study Network (NEPTUNE).

Methods: Forty-eight histologic (37 glomerular, 9 tubulointerstitial, 2 vascular) and 20 ultrastructural descriptors were quantified by applying the NEPTUNE Digital Pathology Scoring System to NEPTUNE kidney biopsies. Read More

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Associations Between Cessation of Second-Line Therapies and Relapse Rates of Childhood Refractory Minimal-Change Nephrotic Syndrome: A Single-Center, Retrospective Chart Review.

Curr Ther Res Clin Exp 2022 12;96:100671. Epub 2022 Apr 12.

Department of Pediatric Nephrology, Rheumatology, and Immunology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: Most patients (≥85%) with minimal-change nephrotic syndrome (MCNS) respond to corticosteroid treatment. However, about 10% to 20% of patients with MCNS have steroid-resistant nephrotic syndrome and 25% to 43% of patients have steroid-dependent nephrotic syndrome or frequent-relapse steroid-sensitive nephrotic syndrome. Patients with refractory MCNS are treated with various second-line therapies. Read More

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New-onset and relapse of nephrotic syndrome following COVID-19 vaccination: a questionnaire survey in Japan.

Clin Exp Nephrol 2022 May 15. Epub 2022 May 15.

Joint Research Team from Japanese Society of Nephrology and the Progressive Renal Diseases Research, Research on Intractable Disease, from the Ministry of Health, Labour and Welfare of Japan, Special Study Group for Nephrotic Syndrome, Tokyo, Japan.

Background: Recent clinical reports indicate a correlation between new-onset and relapse of nephrotic syndrome (NS) following coronavirus 2019 (COVID-19) vaccination in patients with glomerular diseases. However, there are no reports of a nationwide survey on NS following COVID-19 vaccination in Japan.

Methods: We conducted a web-based survey of council members of the Japanese Society of Nephrology (581 members, 382 facilities) to elucidate the relationship between COVID-19 vaccination and new-onset and relapse of NS. Read More

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Expression of VEGF, EGF, and Their Receptors in Squamous Esophageal Mucosa, with Correlations to Histological Findings and Endoscopic Minimal Changes, in Patients with Different GERD Phenotypes.

Int J Environ Res Public Health 2022 Apr 27;19(9). Epub 2022 Apr 27.

Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland.

Background: Gastroesophageal reflux disease (GERD) may present as nonerosive reflux disease (NERD), erosive esophagitis (EE), or be complicated by Barrett's esophagus (BE). The explanation as to what determines the phenotype of GERD is awaited. Therefore, we assessed the correlation between the growth factors expression and endoscopic as histologic findings in GERD patients. Read More

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Health-Related Quality of Life with Diroximel Fumarate in Patients with Relapsing Forms of Multiple Sclerosis: Findings from Qualitative Research Using Patient Interviews.

Adv Ther 2022 May 13. Epub 2022 May 13.

Biogen, 225 Binney St., Cambridge, MA, USA.

Introduction: Diroximel fumarate (DRF) is an oral fumarate for relapsing multiple sclerosis (MS). Clinical and real-world studies of DRF have demonstrated improved gastrointestinal (GI) tolerability and low (< 1%) GI-related treatment discontinuation versus dimethyl fumarate (DMF) and high rates of treatment adherence. Our aim was to conduct a concept elicitation study to identify treatment-related concepts most meaningful to patients and to evaluate how these concepts shape the patient perspective of DRF. Read More

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Minimal clinically important difference of the King's Parkinson's disease Pain Scale.

Disabil Rehabil 2022 May 12:1-4. Epub 2022 May 12.

Department of Neurosciences, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.

Objective: Pain is a common and debilitating symptom of Parkinson's disease (PD) and has no specific treatment. King's Parkinson's disease Pain Scale (KPPS) is the only specific scale for pain measurement in PD with established psychometric properties. The minimal clinically important difference (MCID) of KPPS, an important parameter for the design and interpretation of therapeutic interventions, has not yet been measured. Read More

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Optimised systematic review tool: Application to candidate biomarkers for the diagnosis of hepatocellular carcinoma.

Cancer Epidemiol Biomarkers Prev 2022 May 11. Epub 2022 May 11.

Imperial College London, London, United Kingdom.

This review aims to develop an appropriate review tool for systematically collating metabolites that are dysregulated in disease and applies the method to identify novel diagnostic biomarkers for hepatocellular carcinoma (HCC). Studies that analysed metabolites in blood or urine samples where HCC was compared with comparison groups (healthy, pre-cirrhotic liver disease, cirrhosis) were eligible. Tumour tissue was included to help differentiate primary and secondary biomarkers. Read More

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Analysis of the compound muscle action potential scan: Step index (STEPIX) and amplitude index (AMPIX).

Clin Neurophysiol 2022 Apr 26. Epub 2022 Apr 26.

Academic Hospital, Dept. of Clinical Neurophysiology, Uppsala, Sweden.

Objective: The compound muscle action potential (CMAP) scan is useful to study motor unit (MU) loss. It is of interest to develop simple measurements of the scan.

Methods: CMAP scan recordings were performed in the abductor pollicis brevis muscle of 20 control subjects and 26 patients with amyotrophic lateral sclerosis (ALS). Read More

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Coronavirus Disease-19 in a patient with minimal change nephrotic syndrome undergoing rituximab monotherapy.

Saudi J Kidney Dis Transpl 2021 Sep-Oct;32(5):1505-1506

Department of Infectious Diseases, Kameda Medical Center, Kamogawa, Japan.

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Dent Disease Type 1: A Diagnostic Dilemma and Review.

Cureus 2022 Apr 7;14(4):e23910. Epub 2022 Apr 7.

Pediatrics, St. John's Medical College Hospital, Bengaluru, IND.

This case report describes a boy with a rare genetic disease that primarily affects the kidneys and has implications on growth and development. Dent disease type 1 is an X-linked tubulopathy mainly caused by inactivating mutations in the chloride voltage-gated channel 5 (CLCN5) gene. It is a rare but important diagnosis for children with variable phenotypic presentations that can include low molecular weight proteinuria (LMWP), nephrocalcinosis, bony deformities and possible progression to early-onset renal failure. Read More

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Effect of nutritional calcium and phosphate loading on calciprotein particle kinetics in adults with normal and impaired kidney function.

Sci Rep 2022 05 5;12(1):7358. Epub 2022 May 5.

Department of Nephrology, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC, 3052, Australia.

Plasma approaches metastability with respect to its calcium and phosphate content, with only minor perturbations in ionic activity needed to sustain crystal growth once nucleated. Physiologically, calcium and phosphate are intermittently absorbed from the diet each day, yet plasma concentrations of these ions deviate minimally post-prandially. This implies the existence of a blood-borne mineral buffer system to sequester calcium phosphates and minimise the risk of deposition in the soft tissues. Read More

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Characteristics of responders to atropine 0.01% as treatment in Asian myopic children.

Sci Rep 2022 May 5;12(1):7380. Epub 2022 May 5.

Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-gong Rd., Neihu Dist., Taipei, 114, Taiwan, ROC.

Recently, low-concentration atropine (0.01%) has gained increased attention in controlling myopia progression with satisfying effects and minimal side effects. However, studies concerning responders to 0. Read More

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Deflazacort dose optimization and safety evaluation in Duchenne muscular dystrophy (DOSE): A randomized, double-blind non-inferiority trial.

Eur J Paediatr Neurol 2022 Apr 20;38:77-84. Epub 2022 Apr 20.

Pediatric Neurology Unit, Department of Pediatrics, Advanced Pediatrics Centre, PGIMER, Chandigarh, 160012, India.

Background: US food and drug administration has recently approved deflazacort for Duchenne muscular dystrophy (DMD) and recommended the dosage of 0.9 mg/kg/d for patients aged ≥5years. However, data assessing the minimal efficacious dose and need of dose-titration based on age or disease severity is limited. Read More

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Minimal Change Disease Is Associated With Endothelial Glycocalyx Degradation and Endothelial Activation.

Kidney Int Rep 2022 Apr 16;7(4):797-809. Epub 2021 Dec 16.

Section of Pediatric Nephrology, Department of Pediatrics, Children's Hospital Colorado, Aurora, Colorado, USA.

Introduction: Minimal change disease (MCD) is considered a podocyte disorder triggered by unknown circulating factors. Here, we hypothesized that the endothelial cell (EC) is also involved in MCD.

Methods: We studied 45 children with idiopathic nephrotic syndrome (44 had steroid sensitive nephrotic syndrome [SSNS], and 12 had biopsy-proven MCD), 21 adults with MCD, and 38 healthy controls (30 children, 8 adults). Read More

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Minimal Change Disease: More Than a Podocytopathy?

Kidney Int Rep 2022 Apr 3;7(4):675-677. Epub 2022 Mar 3.

Radboud University Nijmegen Medical Center, Nijmegen, Gelderland, The Netherlands.

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Test-Retest Reliability and Minimal Detectable Change of Four Cognitive Tests in Community-Dwelling Older Adults.

J Alzheimers Dis 2022 Apr 25. Epub 2022 Apr 25.

School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

Background: Cognitive test-retest reliability measures can be used to evaluate meaningful changes in scores.

Objective: This analysis aimed to develop a comprehensive set of test-retest reliability values and minimal detectable change (MDC) values for a cognitive battery for community-dwelling older individuals in Australia and the U.S. Read More

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'Shifting from anxiety to the new normal': A qualitative exploration on personal protective equipment use by otorhinolaryngology health-care professionals during COVID-19 pandemic.

Niger Postgrad Med J 2022 Apr-Jun;29(2):110-115

Department of ENT, JIPMER, Puducherry, India.

Background: The novel coronavirus pandemic has influenced the working practice of health-care professionals who come across symptomatic and asymptomatic COVID patients in their day-to-day practice. Especially, among HCWs in otorhinolaryngology, with the risk of exposure being high, hence were mandated to use personal protective equipment (PPE).

Materials And Methods: The change in perceptions and patterns of PPE use throughout the COVID-19 pandemic was studied in detail through interviews conducted among 15 key informants, and the data were analyzed using health belief model in our study. Read More

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RNA-seq profiling of tubulointerstitial tissue reveals a potential therapeutic role of dual anti-phosphatase 1 in glomerulonephritis.

J Cell Mol Med 2022 Apr 29. Epub 2022 Apr 29.

Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

Transcriptome profiling of tubulointerstitial tissue in glomerulonephritis may reveal a potential tubulointerstitial injury-related biomarker. We profiled manually microdissected tubulointerstitial tissue from biopsy cores of 65 glomerulonephritis cases, including 43 patients with IgA nephropathy, 3 with diabetes mellitus nephropathy, 3 with focal segmental glomerulosclerosis, 3 with lupus nephritis, 4 with membranous nephropathy and 9 with minimal change disease, and additional 22 nephrectomy controls by RNA sequencing. A potential biomarker was selected based on the false discovery rate, and experiments were performed in TNF-α-stimulated primary cultured human tubular epithelial cells (hTECs). Read More

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Longitudinal Cognitive Changes in Genetic Frontotemporal Dementia Within the GENFI Cohort.

Neurology 2022 Apr 28. Epub 2022 Apr 28.

Divison of Neuroscience & Experimental Psychology, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, United Kingdom.

Background And Objectives: Disease-modifying therapeutic trials for genetic frontotemporal dementia (FTD) are underway, but sensitive cognitive outcome measures are lacking. The aim of this study was to identify such cognitive tests in early stage FTD by investigating firstly, cognitive decline in a large cohort of genetic FTD pathogenic variant carriers, and secondly, whether gene-specific differences are moderated by disease stage (asymptomatic, prodromal and symptomatic).

Methods: , and pathogenic variant carriers as well as controls underwent a yearly neuropsychological assessment covering eight cognitive domains, as part of the Genetic FTD Initiative (GENFI), a prospective multicenter cohort study. Read More

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Patient experienced symptom state in rheumatoid arthritis: sensitivity to change in disease activity and impact.

Rheumatology (Oxford) 2022 Apr 28. Epub 2022 Apr 28.

Department of Rheumatology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal).

Objectives: The Patient Experienced Symptom State (PESS) is a single-question, patient-reported outcome which is validated to assess global disease impact in rheumatoid arthritis (RA). This study addresses its sensitivity to change and reliability.

Methods: Disease activity, disease impact in the 7 domains of RAID and PESS were assessed in patients with RA from the NOR-DMARD registry, at two visits, six-months apart. Read More

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Efficacy and safety of electroacupuncture at auricular concha region in promoting of rehabilitation of ischemic stroke patients with upper limb motor dysfunction: A study protocol for a randomized pilot trial.

Medicine (Baltimore) 2022 Apr 15;101(15):e28047. Epub 2022 Apr 15.

Department of Rehabilitation Medicine, The Second Affiliated Hospital of Chongqing Medical University, 76 Linjiang Road, Yuzhong District, China.

Introduction: Ischemic stroke (IS) is the one of the most severe neurological disease, survivors may live with upper limb motor dysfunction (ULMD) resulting in heavy social and economic burden. Nowadays, there are few approaches to promote the rehabilitation of ULMD. Auricular acupuncture (electroacupuncture [EA]) has long been used in the treatment of neurological disorders in China. Read More

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Projected impact of change in the percentage of energy from each NOVA group intake on cardiovascular disease mortality in Brazil: a modelling study.

BMJ Open 2022 Apr 26;12(4):e057953. Epub 2022 Apr 26.

Department of Public Health and Policy, University of Liverpool, Liverpool, UK.

Objective: Estimate reductions in cardiovascular mortality achievable through improvement in nutrient intakes according to processing level (NOVA classification), that is, reducing consumption of culinary ingredients (G2), processed (G3) and ultra-processed foods (G4) while encouraging consumption of unprocessed and minimally processed foods (G1).

Design: Modelling study.

Setting: General adult population of Brazil. Read More

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[A possible relationship between anti-SARS-CoV-2 vaccination and glomerular diseases: food for thought for the nephrologist].

G Ital Nefrol 2022 Apr 21;39(2). Epub 2022 Apr 21.

Dipartimento di Sanità Pubblica, Università degli Studi di Napoli "Federico II", Napoli, Italy.

In order to fight the SARS-CoV-2 pandemic, mass-vaccination programs have been launched globally starting December 2020. The pace of COVID-19 vaccines development was impressive and although data from clinical trials and post-authorization studies showed acceptable safety profile, additional studies and long-term population-level surveillance are needed. A possible link between all type of vaccination and immunological diseases is perhaps one of the hottest topics in literature; correspondingly, there is growing concern over the small but growing number of case reports linking COVID-19 vaccines with the development of glomerular disease. Read More

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