4,395 results match your criteria Minimal-Change Disease


Nanoscale Imaging of Kidney Glomeruli Using Expansion Pathology.

Front Med (Lausanne) 2018 21;5:322. Epub 2018 Nov 21.

Department of Biological Sciences, Mellon College of Science, Carnegie Mellon University, Pittsburgh, PA, United States.

Kidney glomerular diseases, such as the minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), and other nephrotic syndromes, are typically diagnosed or confirmed via electron microscopy. Although optical microscopy has been a vital tool to examine clinical specimens for diagnoses in pathology for decades, the optical resolution is constricted by the physical diffraction limit of the optical microscope, which prevents high-resolution investigation of subcellular anatomy, such as of the podocyte tertiary foot processes. Here, we describe a simple, fast, and inexpensive protocol for nanoscale optical imaging of kidney glomeruli. Read More

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November 2018
1 Read

The Kidney Specific Protein myo-Inositol Oxygenase, a Potential Biomarker for Diabetic Nephropathy.

Kidney Blood Press Res 2018 Nov 30;43(6):1772-1785. Epub 2018 Nov 30.

Department of Nephrology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha,

Background/aims: Renal tubular injury plays an important role in the progression of diabetic nephropathy (DN). However, there is a lack of specific biomarkers for tubular damage in incipient DN. We have evaluated the role of myo-inositol oxygenase (MIOX) in the tubular injury of DN, but whether it could serve as a new biomarker for the early diagnosis of DN is unclear. Read More

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November 2018

Efficacy and safety of mycophenolate mofetil versus levamisole in frequently relapsing nephrotic syndrome: an open-label randomized controlled trial.

Kidney Int 2018 Nov 22. Epub 2018 Nov 22.

Division of Nephrology, Department of Pediatrics, Indian Council of Medical Research Advanced Center for Research in Nephrology, India Institute of Medical Sciences, New Delhi, India. Electronic address:

Both levamisole and mycophenolate mofetil (MMF) prevent relapses in patients with frequently relapsing nephrotic syndrome; however, their efficacy has not been compared prospectively. This single-center, randomized, open-label trial enrolled 149 children ages 6-18 years with frequently relapsing or steroid-dependent nephrotic syndrome. Participants were randomized in a 1:1 ratio to receive therapy with MMF (750-1000 mg/m daily) or levamisole (2-2. Read More

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November 2018
1 Read

Changes in the diagnosis of glomerular diseases in east China: a 15-year renal biopsy study.

Ren Fail 2018 Nov;40(1):657-664

a Kidney Disease Centre, The First Affiliated Hospital , Zhejiang University School of Medicine , Hangzhou , China.

Background: There have been some gradual changes in the distribution of renal biopsy pathological diagnoses during recent years. This study aimed to show changes in renal disease prevalence in China by investigating 10 patients diagnosed at our Kidney Disease Centre during the last 15 years.

Methods And Results: All patients aged 15-year-old or older who underwent renal biopsy at the First Affiliated Hospital, Zhejiang University, from 2001 to 2015 were enrolled. Read More

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November 2018
1 Read

Efficacy of Semiannual Single Fixed Low-Dose Rituximab Therapy in Steroid-Dependent Minimal Change Nephrotic Syndrome: A Case Series.

Case Rep Nephrol Dial 2018 Sep-Dec;8(3):230-237. Epub 2018 Oct 22.

Division of Nephrology, Department of Medicine, Yachiyo Medical Center, Tokyo Women's Medical University, Chiba, Japan.

The frequency of using rituximab to treat refractory nephrotic syndrome has recently been increasing, and the conventional dose of rituximab used to treat it, 375 mg/m body surface area once weekly for 4 weeks, has been modelled on the chemotherapy regimen for B-cell non-Hodgkin's lymphoma. The dose and intervals of rituximab in refractory nephrotic syndrome remain controversial. Clear lymphoma cell hyperplasia is seen in lymphoma patients, but not in nephrotic syndrome patients. Read More

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October 2018
9 Reads

Early Skeletal Muscle Loss in Non-Small Cell Lung Cancer Patients Receiving Chemoradiation and Relationship to Survival.

Support Care Cancer 2018 Nov 26. Epub 2018 Nov 26.

Radiation Therapy Services, Peter MacCallum Cancer Centre, Melbourne, Victoria, 3002, Australia.

Purpose: Sarcopenia is associated with reduced survival in cancer. Currently, data on sarcopenia at presentation and muscle loss throughout treatment are unknown in patients receiving chemoradiation therapy (CRT) for non-small cell lung cancer (NSCLC). This study evaluated skeletal muscle changes in NSCLC patients receiving CRT and relationship with survival. Read More

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November 2018

Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cells.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Nov 22. Epub 2018 Nov 22.

Hormel Institute, University of Minnesota, Austin, MN 55912, USA. Electronic address:

Human GLTP on chromosome 12 (locus 12q24.11) encodes a 24 kD amphitropic lipid transfer protein (GLTP) that mediates glycosphingolipid (GSL) intermembrane trafficking and regulates GSL homeostatic levels within cells. Herein, we provide evidence that GLTP overexpression inhibits the growth of human colon carcinoma cells (HT-29; HCT-116), but spares normal colonic cells (CCD-18Co). Read More

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November 2018

The utility of urinary CD80 as a diagnostic marker in patients with renal diseases.

Sci Rep 2018 Nov 23;8(1):17322. Epub 2018 Nov 23.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

CD80, which regulates T cell activation, may provide a differential diagnostic marker between minimal change disease (MCD) and other renal diseases, including focal segmental glomerular sclerosis (FSGS). However, recent reports show contrasting results. Therefore, we evaluated the utility of urinary CD80 as a diagnostic biomarker. Read More

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November 2018
4 Reads

Neurofilament heavy polypeptide protects against reduction in synaptopodin expression and prevents podocyte detachment.

Sci Rep 2018 Nov 21;8(1):17157. Epub 2018 Nov 21.

Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421, Japan.

Podocytes are highly specialized cells that line the glomerulus of the kidney and play a role in filtration. Podocyte injury plays a critical role in the development of many kidney diseases, but the underlying mechanisms remain unclear. In this study, we identified that neurofilament heavy polypeptide (NEFH), an intermediate filament component, protects podocyte from injury. Read More

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November 2018
1 Read

Expression of DENDRIN in several glomerular diseases and correlation to pathological parameters and renal failure - preliminary study.

Diagn Pathol 2018 Nov 20;13(1):90. Epub 2018 Nov 20.

Department of Pathology, Forensic medicine and Cytology, University Hospital Centre Split, Split, Croatia.

Background: In glomerular injury dendrin translocates from the slit diaphragm to the podocyte nucleus, inducing apoptosis. We analyzed dendrin expression in IgA glomerulonephritis and Henoch Schönlein purpura (IgAN/HSP) versus in podocytopathies minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), and compared it to pathohistological findings and renal function at the time of biopsy and the last follow-up.

Methods: Twenty males and 13 females with median of age 35 years (min-max: 3-76) who underwent percutaneous renal biopsy and had diagnosis of glomerular disease (GD) were included in this retrospective study. Read More

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November 2018
21 Reads

Minimal change nephrotic syndrome in patients infected with human immunodeficiency virus: a retrospective study of 8 cases.

BMC Nephrol 2018 Nov 20;19(1):331. Epub 2018 Nov 20.

AP-HP (Assistance Publique-Hôpitaux de Paris), Service de Néphrologie et de Transplantation, Centre de Référence Maladie Rare Syndrome Néphrotique Idiopathique, Hôpital Henri-Mondor/Albert-Chenevier, F-94000, Créteil, France.

Background: Human immunodeficiency virus (HIV) is associated with diverse glomerular diseases. Characteristics of minimal change nephrotic syndrome (MCNS) in this setting have been little studied, and the specific features of this uncommon association remain to be determined.

Methods: We conduct a retrospective study. Read More

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November 2018
6 Reads

A Decision Analysis of Follow-up and Treatment Algorithms for Nonsolid Pulmonary Nodules.

Radiology 2018 Nov 20:180867. Epub 2018 Nov 20.

From the Department of Radiology, Brigham and Women's Hospital, Boston, Mass (M.M.H.); Institute for Technology Assessment, Massachusetts General Hospital, 101 Merrimac St, 10th Floor, Boston, MA 02114 (L.L.P., A.L.E., C.Y.K.); Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa, (E.M.B.); and Harvard Medical School, Boston, Mass (C.Y.K.).

Purpose To evaluate management strategies and treatment options for patients with ground-glass nodules (GGNs) by using decision-analysis models. Materials and Methods A simulation was developed for 1 000 000 hypothetical patients with GGNs undergoing follow-up per the Lung Imaging Reporting and Data System (Lung-RADS) recommendations. The initial age range was 55-75 years (mean, 64 years). Read More

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November 2018
1 Read

Nephrotic Syndrome.

Pediatr Clin North Am 2019 Feb;66(1):73-85

Division of Pediatric Nephrology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 2015 Uppergate Drive Northeast, Atlanta, GA 30322-1015, USA.

Nephrotic syndrome is characterized by edema, proteinuria, hypoalbuminemia, and hyperlipidemia. Minimal change disease, the most common cause in childhood, generally responds to corticosteroids, although most patients experience disease relapses. Focal segmental glomerulosclerosis is usually resistant to corticosteroids and carries a significant risk of kidney failure, necessitating renal transplantation. Read More

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February 2019
1 Read

Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study.

Kidney Int Rep 2018 Nov 3;3(6):1373-1384. Epub 2018 Aug 3.

Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, New York, USA.

Introduction: The Cure Glomerulonephropathy Network (CureGN) is a 66-center longitudinal observational study of patients with biopsy-confirmed minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or IgA nephropathy (IgAN), including IgA vasculitis (IgAV). This study describes the clinical characteristics and treatment patterns in the IgA cohort, including comparisons between IgAN versus IgAV and adult versus pediatric patients.

Methods: Patients with a diagnostic kidney biopsy within 5 years of screening were eligible to join CureGN. Read More

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November 2018
6 Reads

Persistent metabolic changes in HIV-infected patients during the first year of combination antiretroviral therapy.

Sci Rep 2018 Nov 16;8(1):16947. Epub 2018 Nov 16.

Department of Gastroenterology and Hepatology, Erasmus Medical Center, Wytemaweg 80, 3015 CE, Rotterdam, The Netherlands.

The HIV-human metabolic relationship is a complex interaction convoluted even more by antiretroviral therapy (cART) and comorbidities. The ability of cART to undo the HIV induced metabolic dysregulation is unclear and under-investigated. Using targeted metabolomics and multiplex immune biomarker analysis, we characterized plasma samples obtained from 18 untreated HIV-1-infected adult patients and compared these to a non-HIV infected (n = 23) control population. Read More

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November 2018
5 Reads
5.080 Impact Factor

Does What Goes Around Always Come Around?

Authors:
Howard Trachtman

Clin J Am Soc Nephrol 2018 Nov 15. Epub 2018 Nov 15.

Division of Nephrology, Department of Pediatrics, New York University Langone Health, New York, New York

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November 2018
1 Read

Urine afamin and afamin-creatinine ratio as biomarkers for kidney injury.

Biomark Med 2018 Nov 15. Epub 2018 Nov 15.

Department of Clinical Laboratory, Peking University First Hospital, 100034, Beijing, PR China.

Aim: The aim of this study was to evaluate the urine afamin (uAFM) and afamin-creatinine ratio (AfCR) levels in patients with glomerulonephritis.

Patients & Methods: We determined uAFM and AfCR of 247 healthy volunteers and 129 biopsy-proven glomerulonephritis patients.

Results: Analytical evaluation study revealed the assay is a reliable and robust test for measuring uAFM. Read More

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November 2018
2 Reads

Comparative Analysis of Podocyte Foot Process Morphology in Three Species by 3D Super-Resolution Microscopy.

Front Med (Lausanne) 2018 30;5:292. Epub 2018 Oct 30.

Institute for Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.

Since the size selectivity of the filtration barrier and kidney function are highly dependent on podocyte foot process morphology, visualization of foot processes is important. However, the size of foot processes is below the optical resolution of light microscopy. Therefore, electron microcopy has been indispensable to detect changes in foot process morphology so far, but it is a sophisticated and time-consuming technique. Read More

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October 2018
1 Read

Impairments in Postural Control and Re-test Reliability of Dynamic Posturographic Measures after Lung Transplantation.

Am J Phys Med Rehabil 2018 Nov 12. Epub 2018 Nov 12.

Department of Thoracic Surgery, Vienna Medical University, Vienna, Austria.

Objective: To classify impairments in postural control using computerized posturography in lung transplant recipients (LuTXr) undergoing subacute rehabilitation, and to examine the re-test reliability of these measures.

Methods: In a prospective repeated-measures study, 50 LuTXr underwent clinical and quantitative posturographic testing (SMART EquiTest), which included the Sensory Organisation Test (SOT), Motor Control Test (MCT) and Limits of Stability Test (LOS). Testing was repeated after 1-to-2 days and upon completion of rehabilitation, two months later. Read More

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November 2018
1 Read

CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease.

Am J Kidney Dis 2018 Nov 9. Epub 2018 Nov 9.

Center for Translational Science, Children's National Health System, Washington, DC.

Rationale & Objectives: Glomerular diseases, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A (IgA) nephropathy, share clinical presentations, yet result from multiple biological mechanisms. Challenges to identifying underlying mechanisms, biomarkers, and new therapies include the rarity of each diagnosis and slow progression, often requiring decades to measure the effectiveness of interventions to prevent end-stage kidney disease (ESKD) or death.

Study Design: Multicenter prospective cohort study. Read More

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November 2018
6 Reads

The Role of Glucocorticoid Receptors in Podocytes and Nephrotic Syndrome.

Nucl Receptor Res 2018 24;5. Epub 2018 Apr 24.

Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.

Glucocorticoid receptor (GC), a founding member of the nuclear hormone receptor superfamily, is a glucocorticoid-activated transcription factor that regulates gene expression and controls the development and homeostasis of human podocytes. Synthetic glucocorticoids are the standard treatment regimens for proteinuria (protein in the urine) and nephrotic syndrome (NS) caused by kidney diseases. These include minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN) and immunoglobulin A nephropathy (IgAN) or subsequent complications due to diabetes mellitus or HIV infection. Read More

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April 2018
1 Read

Nephrotic syndrome associated with Kimura's disease: a case report and literature review.

BMC Nephrol 2018 Nov 8;19(1):316. Epub 2018 Nov 8.

Department of Nephrology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No.32, West Section 2, Ring 1 Road, Chengdu, 610072, Sichuan, China.

Background: Kimura's disease (KD) is a rare chronic inflammatory disorder with a high incidence of renal involvement. In this report, we present a case study of KD-associated nephrotic syndrome combined with minimal change disease (MCD) and acute renal tubular injury. Meanwhile, the clinical and histopathological characteristics of 26 patients with KD presenting with renal involvement were retrospectively evaluated. Read More

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November 2018
2 Reads
1.520 Impact Factor

Water-Borne Perovskite Quantum Dot-Loaded, Polystyrene Latex Ink.

Front Chem 2018 23;6:453. Epub 2018 Oct 23.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry Jilin University, Changchun, China.

Highly lipophilic nanocrystals (NCs) of cesium lead halides were successfully embedded in polystyrene (PS) particles by deliberately controlling the swelling of the PS particles in the mixtures of good and bad organic solvents. The resulting composite particles were readily transferred into water via simple stepwise solvent exchange, which yielded water-borne perovskite NC-based inks with outstanding structural and chemical stability in aqueous media. Minimal change in the photoluminescence (PL) of the NCs loaded in the PS particles was visible after 1 month of incubation of the composite particles in water in a broad pH range from 1 to 14, which could otherwise be hardly realized. Read More

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October 2018
2 Reads

Clinical significance of serum and mesangial galactose-deficient IgA1 in patients with IgA nephropathy.

PLoS One 2018 2;13(11):e0206865. Epub 2018 Nov 2.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.

Introduction: Galactose-deficient IgA1 (Gd-IgA1) is a critical pathogenic factor for IgA nephropathy (IgAN), but its value as a disease-specific biomarker remains controversial. We aimed to clarify the clinical significance of Gd-IgA1 in patients with IgAN.

Methods: We retrospectively reviewed 111 patients who were diagnosed with IgAN based on the findings of renal biopsies (RB) at Showa University Hospital since 2007. Read More

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November 2018
5 Reads

An open-label randomized controlled trial of low-dose corticosteroid plus enteric-coated mycophenolate sodium versus standard corticosteroid treatment for minimal change nephrotic syndrome in adults (MSN Study).

Kidney Int 2018 Dec 29;94(6):1217-1226. Epub 2018 Oct 29.

AP-HP (Assistance Publique des Hôpitaux de Paris), Groupe Hospitalier Henri-Mondor, Department of Nephrology and Renal Transplantation, Créteil, France; UPEC (Université Paris Est Créteil), INSERM (Institut National de la Santé et de la Recherche Médicale) U955, Institut Mondor de Recherche Biomédicale (IMRB), Equipe 21, Créteil, France. Electronic address:

First-line therapy of minimal change nephrotic syndrome (MCNS) in adults is extrapolated largely from pediatric studies and consists of high-dose oral corticosteroids. We assessed whether a low corticosteroid dose combined with mycophenolate sodium was superior to a standard oral corticosteroid regimen. We enrolled 116 adults with MCNS in an open-label randomized controlled trial involving 32 French centers. Read More

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December 2018
4 Reads

An imaging system integrating optical coherence tomography and interferometry for in vivo measurement of the thickness and dynamics of the tear film.

Biomed Eng Online 2018 Nov 1;17(1):164. Epub 2018 Nov 1.

School of Optometry, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.

Background: The outermost layer of the tear film consists of a thin lipid layer (LL). The lipid layer serves as a barrier against evaporation of the aqueous component of the tear film. The ability to simultaneously image both the lipid layer thickness and overall tear film thickness is novel, and will help further understandings of mechanisms of how the lipid layer assembles and interacts with the full tear film thickness. Read More

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November 2018

Analysis of native kidney biopsy: Data from a single center from Bihar, India.

Saudi J Kidney Dis Transpl 2018 Sep-Oct;29(5):1174-1180

Department of Nephrology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.

This is a retrospective study of all native kidney biopsies performed at our center between October 1, 2012 and March 31, 2015. Relevant clinical and laboratory variables were recorded. Biopsy samples were processed for light microscopy and immunofluorescence in all cases. Read More

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November 2018
3 Reads

Histological heterogeneity in a large clinical cohort of juvenile idiopathic inflammatory myopathy: analysis by myositis autoantibody and pathological features.

Neuropathol Appl Neurobiol 2018 Oct 31. Epub 2018 Oct 31.

Developmental Biology of Birth Defects, Developmental Biology and Cancer Programme, UCL GOS Institute of Child Health, UCL London, UK.

Aim: Juvenile idiopathic inflammatory myopathies (IIM) have been recently reclassified into clinico-serological subgroups. Myopathological correlates of the subgroups are incompletely understood.

Methods: We studied muscle biopsies from 101 children with clinically and serologically-defined juvenile IIM from the UK JDM Cohort and Biomarker Study by applying the international JDM score tool, myopathological review, and C5b-9 complement analysis. Read More

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October 2018
3 Reads

[Clinical analysis of six cases with the glomerulitis after allogeneic hematopoietic stem cell transplantation].

Zhonghua Xue Ye Xue Za Zhi 2018 Sep;39(9):757-760

Department of Hematology, Affiliated Cancer Hospital Zhengzhou University, Henan Tumor Hospital, Institute of Hematology, Zhengzhou 450003, China.

To explore the occurrence, clinical characteristics, diagnosis and treatment of glomerulitis after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Analysis were carried out based on the clinical data of 6 patients with glomerulitis following allo-HSCT hospitalized in Henan Tumor Hospital from January 2008 to December 2016, and the clinical manifestation, pathology, diagnosis, treatment and outcome were investigated. The occurrence of glomerulitis was 1. Read More

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September 2018
7 Reads

Limited Phenotypic and Functional Plasticity of Influenza Virus-Specific Memory CD8 T Cells during Activation in an Alternative Cytokine Environment.

J Immunol 2018 Dec 26;201(11):3282-3293. Epub 2018 Oct 26.

Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia

Naive CD8 T cells show phenotypic, functional, and epigenetic plasticity, enabling differentiation into distinct cellular states. However, whether memory CD8 T cells demonstrate similar flexibility upon recall is poorly understood. We investigated the potential of influenza A virus (IAV)-specific memory CD8 T cells from mice to alter their phenotype and function in response to reactivation in the presence of IL-4 and anti-IFN-γ Ab (type 2 conditions). Read More

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December 2018
4 Reads

Emerging therapeutic strategies for minimal change disease and focal and segmental glomerulosclerosis.

Expert Opin Investig Drugs 2018 Nov 30;27(11):839-879. Epub 2018 Oct 30.

a Unit of Nephrology and Dialysis, Department of Internal Medicine , Messina , Italy.

Introduction: Minimal change disease (MCD) and Focal and segmental glomerulosclerosis (FSGS) are two of the major causes of nephrotic syndrome (NS) in children and adults. According to KDIGO (Kidney Disease: Improving Global Outcomes) guidelines, the treatment of adult primary MCD and FSGS should be based on immunosuppressants and antiproteinuric drugs. Recently, Rituximab, a humanized monoclonal antibody (mAb) has emerged as a potential treatment for steroid or calcineurin inhibitor-dependent patients; it has however demonstrated lower efficacy in those with nephrotic syndrome that is resistant to the above indicated drugs. Read More

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November 2018
1 Read
5.530 Impact Factor

Patterns of renal involvement in a cohort of patients with inflammatory bowel disease in Egypt.

Acta Gastroenterol Belg 2018 Jul-Sep;81(3):381-385

Department of Medicine, Cairo University Hospital, Cairo, Egypt.

Background And Study Aim: Renal complications are frequent extraintestinal manifestations in inflammatory bowel disease (IBD). We aimed in our study to describe the spectrum of renal affection in our IBD patients.

Patients And Methods: This study is a retrospective analysis of renal biopsies done for IBD patients who developed renal diseases, at Cairo University Hospital, from June 2005 to Jan. Read More

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October 2018
5 Reads

Management of steroid-resistant nephrotic syndrome in children and adolescents.

Lancet Child Adolesc Health 2018 Dec 18;2(12):880-890. Epub 2018 Oct 18.

Division of Nephrology, Indian Council of Medical Research Advanced Center for Research in Nephrology, All India Institute of Medical Sciences, New Delhi, India.

More than 85% of children and adolescents (majority between 1-12 years old) with idiopathic nephrotic syndrome show complete remission of proteinuria following daily treatment with corticosteroids. Patients who do not show remission after 4 weeks' treatment with daily prednisolone are considered to have steroid-resistant nephrotic syndrome (SRNS). Renal histology in most patients shows presence of focal segmental glomerulosclerosis, minimal change disease, and (rarely) mesangioproliferative glomerulonephritis. Read More

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December 2018
6 Reads

Focal segmental glomerulosclerosis lesion associated with inhibition of tyrosine kinases by lenvatinib: a case report.

BMC Nephrol 2018 Oct 19;19(1):273. Epub 2018 Oct 19.

Department of Hypertension and Nephrology, NTT Medical Centre Tokyo, 5-9-22, Higasi-Gotanda, Shinagawa-ku, Tokyo, 141-8625, Japan.

Background: Lenvatinib is a tyrosine kinase inhibitor with novel binding ability. It is considered the standard of care for metastatic thyroid cancer; moreover, whether it is indicated for other malignant tumors has been examined. Lenvatinib increases the risk of kidney injury in some patients. Read More

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October 2018
8 Reads

Comparison of the response of frequently relapsing steroid-dependent minimal change nephrotic syndrome to rituximab therapy between childhood-onset and adult-onset disease.

Medicine (Baltimore) 2018 Oct;97(42):e12704

Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.

Rituximab has been approved in Japan for the treatment of intractable nephrotic syndrome, but in cases of childhood-onset disease only; its efficacy and safety in adult-onset disease has yet to be established. This study was undertaken to evaluate the efficacy of rituximab and adverse effects in patients with adult-onset minimal change nephrotic syndrome (MCNS).The study involved 32 childhood-onset cases (mean age at onset: 8. Read More

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October 2018
5 Reads

Effect of angiotensin converting enzyme gene I/D polymorphism in South Indian children with nephrotic syndrome.

J Biomed Res 2018 Oct 16. Epub 2018 Oct 16.

Department of Pediatric Nephrology, Institute of Child Health and Hospital for Children, Chennai, Tamil Nadu 600008, India.

Nephrotic syndrome is one of the most common childhood kidney diseases. It is mostly found in the age group of 2 to 8 years. Around 10%-15% of nephrotic syndrome cases are non-responders of steroid treatment (SRNS). Read More

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October 2018
1 Read

Minimal Change Nephrotic Syndrome Relapse after 52 Years of Remission: A Case Report.

Case Rep Nephrol Dial 2018 May-Aug;8(2):178-181. Epub 2018 Aug 31.

Department of Nephrology, Hirosaki University Hospital, Hirosaki, Japan.

Minimal change nephrotic syndrome (MCNS) is the most common cause of nephrotic syndrome in children and can also present in adults. Corticosteroids generally induce remission of MCNS, and relapses are common after reduction or discontinuation of corticosteroids. We experienced a rare case of steroid-sensitive MCNS where the patient relapsed after 52 years of remission. Read More

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August 2018
6 Reads

Linked color imaging improves detection of minimal change esophagitis in non-erosive reflux esophagitis patients.

Endosc Int Open 2018 Oct 8;6(10):E1177-E1183. Epub 2018 Oct 8.

Department of Gastroenterology and Hepatology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China.

 Non-erosive reflux disease (NERD) includes minimal change esophagitis (MCE) and no endoscopic abnormalities. However, for most endoscopists, it is difficult to detect MCE with conventional white-light endoscopy (WLE). Linked color imaging (LCI) technology is the most recently developed image-enhancing technology and improves detection and differentiation of subtle mucosal changes using a color contrast method. Read More

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October 2018
6 Reads

Minimal Change Disease Associated with Ingestion of Poison Sumac.

Chonnam Med J 2018 Sep 27;54(3):201-202. Epub 2018 Sep 27.

Division of Nephrology, Department of Internal Medicine, Wonkwang University Hospital, Wonkwang University School of Medicine, Iksan, Korea.

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September 2018
2 Reads

Kidney-derived c-kit progenitor/stem cells contribute to podocyte recovery in a model of acute proteinuria.

Sci Rep 2018 Oct 3;8(1):14723. Epub 2018 Oct 3.

Interdisciplinary Stem Cell Institute, Leonard M Miller School of Medicine University of Miami, Miami, 33136, Florida, USA.

Kidney-derived c-kit cells exhibit progenitor/stem cell properties and can regenerate epithelial tubular cells following ischemia-reperfusion injury in rats. We therefore investigated whether c-kit progenitor/stem cells contribute to podocyte repair in a rat model of acute proteinuria induced by puromycin aminonucleoside (PAN), the experimental prototype of human minimal change disease and early stages of focal and segmental glomerulosclerosis. We found that c-kit progenitor/stem cells accelerated kidney recovery by improving foot process effacement (foot process width was lower in c-kit group vs saline treated animals, P = 0. Read More

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October 2018
3 Reads

Urinary Exosomal mRNA of WT1 as Diagnostic and Prognostic Biomarker for Diabetic Nephropathy.

J Med Invest 2018 ;65(3.4):208-215

Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School.

Diabetic nephropathy (DN) is the major cause of end-stage renal failure and is associated with increased morbidity and mortality as compared to other causes of renal disease. Albuminuria is often the first clinical indicator of the presence of DN. However, albuminuria or proteinuria is a common symptom in patients with various renal disorders. Read More

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January 2018
4 Reads

Examination of risk scores to better predict hospital-related harms.

Intern Med J 2018 Oct 1. Epub 2018 Oct 1.

Department of Aged Care and Rehabilitation, Caulfield Hospital, Alfred Health, Victoria, Australia.

Background: Many hospitals use predictive scores to identify a person's risk of inpatient falls, pressure injury and malnutrition despite evidence of limited predictive accuracy.

Aim: To examine whether we could improve predictive accuracy by generating a score combining all components of currently-used tools.

Methods: We performed a retrospective, cross-validation study in a single sub-acute (geriatrics and rehabilitation) hospital extracting data regarding hospital risk scores, and incidence of falls, pressure injury, and malnutrition from January 2014 to June 2016. Read More

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October 2018
5 Reads

Comparison of UV protection properties of cotton fabrics treated with aqueous and methanolic extracts of Solanum nigrum and Amaranthus viridis plants.

Photodermatol Photoimmunol Photomed 2018 Sep 24. Epub 2018 Sep 24.

Faculty of Engineering and Technology, National Textile University, Faisalabad, Pakistan.

Harmful effects of ultraviolet rays and protection against them have been long discussed. Numerous synthetic dyes, finishes, UV absorbers, and optical brightening agents are present in the market for decades for achieving UV protection through textiles. However, due to environmental impacts of these chemical agents, textile industry is looking for alternatives. Read More

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September 2018

[What is certain in the treatment of glomerulonephritis?]

Internist (Berl) 2018 Dec;59(12):1268-1278

Klinik für Nieren- und Hochdruckkrankheiten, Uniklinik der RWTH Aachen, Aachen, Deutschland.

Glomerulonephritides essentially all belong to the rare diseases; however, they are the most common cause of end-stage renal disease in young adults. Besides obtaining a specific diagnosis via a renal biopsy, assessing the prognosis constitutes the other essential step in the work-up, since this enables a decision to be made on whether supportive care with relatively few adverse effects is sufficient or whether additional immunosuppressive therapy is required. The latter is discussed focusing on the most common European types of glomerulonephritis: immunoglobulin A nephropathy, membranous glomerulonephritis, minimal change nephropathy and focal segmental glomerulosclerosis. Read More

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December 2018
2 Reads

Respiratory Tract Infection: A Risk Factor for the Onset and Relapse of Adult-Onset Minimal Change Disease in Southern China.

Biomed Res Int 2018 28;2018:1657208. Epub 2018 Aug 28.

Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China.

Aims/introduction: Steroid resistance and frequent relapse are problems in the treatment of minimal change disease (MCD). However, epidemiological factors that influence steroid-resistant and relapse of MCD are rarely reported. This study evaluated potential factors that influence the onset and relapse of MCD and the epidemiological features of southern Chinese patients with adult-onset MCD. Read More

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August 2018
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FTIR characterization of the setting reaction of biodentine™.

Dent Mater 2018 Sep 12. Epub 2018 Sep 12.

Bioclinical Sciences, Faculty of Dentistry, Health Science Centre, Kuwait University, Kuwait. Electronic address:

Objective: To provide insight of the setting reactions of Biodentine™, a hydraulic calcium silicate cement, based upon observations using Fourier Transform Infra-Red (FTIR) spectroscopy.

Methods: FTIR spectra of components before and during the setting reaction were taken using the attenuated total reflectance (ATR) technique. Measurements over wavelengths 600-4000cm were taken at regular intervals for two days. Read More

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September 2018

Improving the quality of maternity services in Nepal through accelerated implementation of essential interventions by healthcare professional associations.

Int J Gynaecol Obstet 2018 Dec 8;143(3):379-386. Epub 2018 Oct 8.

Department of Healthcare Quality and Patient Safety, Institute for Clinical Effectiveness, Buenos Aires, Argentina.

Objective: To assess whether the implementation of a package of activities through the joint action of three international healthcare professional associations (HCPAs) increased the use of essential interventions (EIs) for delivery and neonatal care.

Methods: A noncontrolled pre-intervention versus post-intervention study was conducted from June 13 to December 13, 2016, among women older than 18 years of age, who had delivered at one of two urban tertiary hospitals in Nepal.

Results: The study included 9252 women. Read More

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December 2018
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Idiopathic Nephrotic Syndrome: Characteristics and Identification of Prognostic Factors.

J Clin Med 2018 Sep 9;7(9). Epub 2018 Sep 9.

Service de Néphrologie Transplantation et Dialyse, Centre Hospitalier Universitaire de Bordeaux, Hôpital Pellegrin, 33076 Bordeaux, France.

There are various histopathological forms of idiopathic nephrotic syndrome, including minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). Whereas some relapse predictor factors have been identified in renal transplantation, the clinical future of idiopathic nephrotic syndrome in the native kidney remains uncertain. We designed a multicentric retrospective descriptive cohort study including all patients aged 15 years and over whose renal biopsy confirmed MCD or FSGS between January 2007 and December 2014. Read More

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September 2018
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Movement artefact removal from NIRS signal using multi-channel IMU data.

Biomed Eng Online 2018 Sep 10;17(1):120. Epub 2018 Sep 10.

Florida International University, Miami, FL, 33174, USA.

Background: The non-invasive nature of near-infrared spectroscopy (NIRS) makes it a widely accepted method for blood oxygenation measurement in various parts of the human body. One of the main challenges in this method lies in the successful removal of movement artefacts in the detected signal. In this respect, multi-channel inertia measurement unit (IMU) containing accelerometer, gyroscope and magnetometer can be used for better modelling of movement artefact than using accelerometer only, which as a result, movement artefact can be more accurately removed. Read More

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September 2018
6 Reads

Paraneoplastic immunoglobulin A nephropathy and associated focal segmental glomerulosclerosis in asymptomatic low volume B-cell lymphoma - a case report.

BMC Nephrol 2018 Sep 10;19(1):224. Epub 2018 Sep 10.

Kidney Health Service, Royal Brisbane and Women's Hospital, Brisbane, Australia.

Background: Paraneoplastic glomerulonephritis is rare in haematological malignancies and tends to manifest as minimal change disease, membranous glomerulonephritis or membranoproliferative glomerulonephritis. We present the first report of immunoglobulin A nephropathy and associated focal segmental glomerulosclerosis in a patient with asymptomatic low grade B-cell lymphoma.

Case Presentation: A 53 year old gentleman presented with nephrotic range proteinuria (urine protein creatinine ratio of 662 mg/mmol) on a background of type 2 diabetes mellitus (glycosylated haemoglobin: < 6%), hypertension, obesity (body mass index: 47. Read More

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September 2018
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