7,191 results match your criteria Minimal-Change Disease


Risk Assessment of Diabetes Using the Indian Diabetes Risk Score: A Study on Young Medical Students from Northern India.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):86-90

Department of Community Medicine, Maulana Azad Medical College and Associated Hospitals, New Delhi, India.

Context: Identification of risk factors of diabetes is required among youth as diabetes in young persons is now spreading in epidemic proportions. Indian Diabetes Risk Score (IDRS) is a validated and cost- effective tool to identify risk of diabetes among population.

Aims: Present study was conducted among young medical students to assess risk of type 2 diabetes mellitus (T2DM) using the IDRS and to study association of risk of diabetes with other factors. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_623_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446666PMC

The relationship between thyroid dysfunction and nephrotic syndrome: a clinicopathological study.

Sci Rep 2019 Apr 23;9(1):6421. Epub 2019 Apr 23.

Renal Division, Department of Medicine, West China Hospital of Sichuan University, Kidney Research Institute, Chengdu, 610041, China.

Abnormalities of thyroid function are common in patients with nephrotic syndrome (NS). However, a limited number of studies have reported on the association between clinicopathologic features and thyroid dysfunction in patients with NS. We retrospectively studied 317 patients who had been definitively diagnosed with NS. Read More

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http://dx.doi.org/10.1038/s41598-019-42905-4DOI Listing

Two StereoTactic ablative radiotherapy treatments for localized prostate cancer (2STAR): Results from a prospective clinical trial.

Radiother Oncol 2019 Mar 19;135:86-90. Epub 2019 Mar 19.

Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada; Department of Health Policy, Measurement and Evaluation, University of Toronto, Canada. Electronic address:

Purpose: Ultrahypofractionation is appealing for prostate cancer (PCa) due to low α/β, and increasing the dose per fraction could improve the therapeutic index. Here we report the outcomes of a phase II prostate SABR trial using two fractions.

Methods: Patients had low or intermediate risk prostate cancer. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.03.002DOI Listing

Cardiopulmonary exercise testing for identification of patients with hyperventilation syndrome.

PLoS One 2019 23;14(4):e0215997. Epub 2019 Apr 23.

Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Introduction: Measurement of ventilatory efficiency, defined as minute ventilation per unit carbon dioxide production (VE/VCO2), by cardiopulmonary exercise testing (CPET) has been proposed as a screen for hyperventilation syndrome (HVS). However, increased VE/VCO2 may be associated with other disorders which need to be distinguished from HVS. A more specific marker of HVS by CPET would be clinically useful. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215997PLOS
April 2019
1 Read

A newly established clinical registry of minimal change disease and focal and segmental glomerulosclerosis in Germany.

Nephrol Dial Transplant 2019 Apr 21. Epub 2019 Apr 21.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt
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http://dx.doi.org/10.1093/ndt/gfz046DOI Listing
April 2019
1 Read

C1q nephropathy in adults is a form of focal segmental glomerulosclerosis in terms of clinical characteristics.

PLoS One 2019 19;14(4):e0215217. Epub 2019 Apr 19.

Korean GlomeuloNephritis Study Group, Korean Society of Nephrology, Seoul, Republic of Korea.

Although C1q nephropathy (C1qN) was introduced three decades ago, the clinical significance and renal outcomes of C1qN remain unclear. This study aimed to evaluate the clinical characteristics of C1qN, including renal outcomes, by performing a matched comparison within a multicenter cohort. We enrolled 6,413 adult patients who underwent kidney biopsy between January 2000 and January 2018 at three tertiary hospitals in Korea. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215217PLOS
April 2019
1 Read

Minimal change disease and malaria.

Clin Kidney J 2019 Apr 18;12(2):245-247. Epub 2018 Apr 18.

Cleveland Clinic Akron General/Akron Nephrology Associates, Akron, OH, USA.

Malaria is a tropical disease secondary to the parasite with clinical features ranging from febrile illness to acute renal failure and further renal sequelae. We present a case of a woman minimal change disease secondary to who developed nephrotic range proteinuria and ultimately acute renal failure requiring renal replacement therapy. With proper treatment of her malarial infection as well as long-term renal replacement therapy, she made a full recovery. Read More

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https://academic.oup.com/ckj/article/12/2/245/4976473
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http://dx.doi.org/10.1093/ckj/sfy029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452177PMC
April 2019
3 Reads

Continuous B-cell depletion in frequently relapsing, steroid-dependent and steroid-resistant nephrotic syndrome.

Clin Kidney J 2019 Apr 24;12(2):224-231. Epub 2018 Jul 24.

Vasculitis and Glomerulonephritis Center, Division of Nephrology, Massachusetts General Hospital, Boston, MA, USA.

Background: Patients with frequently relapsing (FR), steroid-dependent (SD) and steroid-resistant (SR) nephrotic syndrome are a therapeutic challenge with limited treatment options. Here, we retrospectively analyze the efficacy and safety of rituximab-induced continuous B-cell depletion in these populations.

Methods: Patients were included if they were at least 18 years of age and had FR, SD or SR minimal change disease (MCD) or primary focal segmental glomerulosclerosis (FSGS) and were treated with a strategy of continuous B-cell depletion. Read More

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http://dx.doi.org/10.1093/ckj/sfy067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452201PMC
April 2019
1 Read

Burden, access and disparities in kidney disease: chronic kidney disease hotspots and progress one step at a time.

Authors:
Alberto Ortiz

Clin Kidney J 2019 Apr 8;12(2):157-159. Epub 2019 Apr 8.

IIS-Fundacion Jimenez Diaz, School of Medicine, Universidad Autonoma de Madrid; Fundacion Renal Iñigo Alvarez de Toledo-IRSIN and REDINREN, Madrid, Spain.

The 2019 International Society of Nephrology World Kidney Day theme is Kidney Health for Everyone Everywhere. It focuses on the uneven burden of acute kidney injury and chronic kidney disease (CKD) in different communities, identifies disparities and challenges in access to care and calls for universal health coverage for prevention and early treatment of kidney disease. This topic is fully in line with the () editorial strategy for improving worldwide kidney care without leaving any community behind. Read More

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https://academic.oup.com/ckj/article/12/2/157/5429454
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http://dx.doi.org/10.1093/ckj/sfz026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452190PMC
April 2019
8 Reads

Do Patient Reported Outcome Measurement Information System (PROMIS) Scales Demonstrate Responsiveness as Well as Disease-Specific Scales in Patients Undergoing Knee Arthroscopy?

Am J Sports Med 2019 Apr 10:363546519832546. Epub 2019 Apr 10.

Department of Orthopaedics and Rehabilitation, University of Rochester, Rochester, New York, USA.

Background: The Patient Reported Outcomes Information System (PROMIS) is an efficient metric able to detect changes in global health.

Purpose: To assess the responsiveness, convergent validity, and clinically important difference (CID) of PROMIS compared with disease-specific scales after knee arthroscopy.

Study Design: Cohort study (Diagnosis); Level of evidence, 2. Read More

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http://dx.doi.org/10.1177/0363546519832546DOI Listing
April 2019
1 Read

Evaluation of left atrial volume and functions by real time three-dimensional echocardiography in patients with subclinical hypothyroidism before and after levothyroxine therapy.

Echocardiography 2019 Apr 9. Epub 2019 Apr 9.

Deparment of Internal Medicine, Ordu University Faculty of Medicine, Ordu, Turkey.

Background/aims: The cardiovascular system is one of the major targets of thyroid hormones. Subclinical hypothyroidism (SCH) is a common disease that can represent "early" thyroid failure. Our aim was to evaluate left atrial (LA) volume and functions in patients with SCH using real time three-dimensional echocardiography (RT3DE) and also to investigate changes in LA parameters after the levothyroxine treatment. Read More

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http://dx.doi.org/10.1111/echo.14324DOI Listing
April 2019
1 Read
1.254 Impact Factor

Open-Label Clinical Trials of Oral Pulse Dexamethasone for Adults with Idiopathic Nephrotic Syndrome.

Am J Nephrol 2019 Apr 9;49(5):377-385. Epub 2019 Apr 9.

Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, Maryland, USA,

Background: In adults with primary focal segmental glomerulosclerosis (FSGS), daily prednisone may induce complete remissions (CR) and partial remissions (PR), but relapses are frequent and adverse events are common.

Methods: We carried out 2 open-label, uncontrolled trials to explore the efficacy and tolerability of pulse oral dexamethasone as an alternative to daily prednisone. We enrolled adult patients with proteinuria > 3. Read More

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http://dx.doi.org/10.1159/000497064DOI Listing
April 2019
1 Read

Comorbidity has no impact on unplanned discharge or functional gains in persons with dysvascular amputation.

J Rehabil Med 2019 Apr 9. Epub 2019 Apr 9.

Physical Medicine and Rehabiltation, Medical Center Arlington, , 76015 Arlington, USA.

Objective: To examine how factors associated with infection, organ failure, poor wound healing, or indices of chronic vascular disease are associated with unplanned transfers and functional gains during inpatient rehabilitation.

Design: Cross-sectional.

Setting: Inpatient rehabilitation unit at an academic medical centre. Read More

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https://www.medicaljournals.se/jrm/content/abstract/10.2340/
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http://dx.doi.org/10.2340/16501977-2554DOI Listing
April 2019
3 Reads

Cast nephropathy associated with monoclonal immunoglobulin M-secreting mucosa-associated lymphoid tissue B-cell lymphoma
.

Clin Nephrol 2019 Apr 9. Epub 2019 Apr 9.

The kidney is among the various anatomical sites involved in mucosa-associated lymphoid tissue (MALT) lymphoma. A variety of renal pathological types, including membranous glomerulopathy, membranoproliferative glomerulonephritis, crescentic IgA nephropathy, minimal change disease, and cryoglobulinemic glomerulopathy, have been reported in MALT lymphoma patients. However, cast nephropathy is extremely rare in MALT lymphoma. Read More

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http://dx.doi.org/10.5414/CN109682DOI Listing
April 2019
4 Reads

Performance of the COPD Assessment Test in patients with connective tissue disease-associated interstitial lung disease.

Respir Med 2019 Apr 1;150:15-20. Epub 2019 Feb 1.

Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan. Electronic address:

Background: Patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) often experience impaired health status. In daily clinical practice, a short and easy instrument for assessing health status would be useful to help better understand the patient's condition. The COPD Assessment Test (CAT) is a simple questionnaire about respiratory symptoms and their impact. Read More

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http://dx.doi.org/10.1016/j.rmed.2019.01.017DOI Listing
April 2019
3 Reads

Microscopic polyangiitis associated with thymic tumor: a case report and review of the literature.

BMC Nephrol 2019 Apr 8;20(1):123. Epub 2019 Apr 8.

Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, 3-20-1 Chuo, Ami, Ibaraki, 300-0395, Japan.

Background: Thymic hyperplasia and thymic epithelial tumor (thymoma) have been associated with a variety of autoimmune diseases. Renal involvement has been reported in patients with thymoma. Minimal change disease and membranous nephropathy are frequently observed in glomerular lesions of thymoma patients, but ANCA-associated renal vasculitis is rare. Read More

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http://dx.doi.org/10.1186/s12882-019-1319-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454690PMC
April 2019
1 Read

Which MCI Patients Should be Included in Prodromal Alzheimer Disease Clinical Trials?

Alzheimer Dis Assoc Disord 2019 Apr 4. Epub 2019 Apr 4.

Institute for Memory Impairments and Neurological Disorders.

Background: Prodromal Alzheimer disease (AD) clinical trials enroll patients with mild cognitive impairment (MCI) meeting biomarker criteria, but specific enrollment criteria vary among trials.

Methods: We used data from AD Neuroimaging Initiative (ADNI) MCI participants to assess AD biomarker eligibility, variation in trial outcome measures, and statistical power.

Results: Most (65%) participants meet eligibility criteria based on low cerebrospinal fluid amyloid beta (Aβ). Read More

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http://dx.doi.org/10.1097/WAD.0000000000000303DOI Listing
April 2019
4 Reads

The King's Brief Interstitial Lung Disease (KBILD) questionnaire: an updated minimal clinically important difference.

BMJ Open Respir Res 2019 18;6(1):e000363. Epub 2019 Feb 18.

Centre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Introduction: The King's Brief Interstitial Lung Disease (KBILD) is a 15-item validated health-related quality of life (HRQOL) questionnaire. The method of scoring the KBILD has recently changed to incorporate a logit-scale transformation from one that used raw item responses, as this is potentially a more linear scale. The aim of this study was to re-evaluate the KBILD minimal clinically important difference (MCID) using the new logit -transformed scoring. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424243PMC
February 2019
4 Reads

Concurrent Paclitaxel and Radiotherapy for Node Positive Breast Cancer.

Gulf J Oncolog 2019 Jan;1(29):14-21

Clinical Oncology Department (NEMROCK), Kasr Al-Ainy School of Medicine, Cairo University, Egypt.

Background: Concurrent chemo-radiotherapy in breast cancer (BC) may yield better local control with minimal toxicity in node positive patients. The feasibility of paclitaxel with radiotherapy was assessed for tolerability, cosmetic outcome as well as local control.

Methods: A prospective feasibility study on forty-three female breast cancer with stage II-III was conducted after definite surgery (modified radical mastectomy and breast conservative surgery). Read More

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January 2019
4 Reads

15-White Dots APP-Coo-Test: a reliable touch-screen application for assessing upper limb movement impairment in patients with cerebellar ataxias.

J Neurol 2019 Apr 6. Epub 2019 Apr 6.

Department of Medical and Surgical Sciences and Biotechnologies (DSBMC), Polo Pontino-University of Rome "Sapienza", Via Faggiana 34, 40100, Latina, Italy.

Background: The use of objective measurements is essential to assess disease progression and to evaluate the effectiveness of rehabilitation protocols and clinical treatments.

Aim: The purpose of this study was to develop a touch-screen application, that we named 15-White Dots APP-Coo-Test (15-WDACT), able to carry out quantitative and objective measurements of the rapid and coordinated upper limb movements, typically impaired in patients with cerebellar ataxias (CA).

Methods: A total of 87 CA patients and 170 healthy subjects participated in this study. Read More

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http://dx.doi.org/10.1007/s00415-019-09299-9DOI Listing
April 2019
3 Reads

Management of Adult Minimal Change Disease.

Clin J Am Soc Nephrol 2019 Apr 5. Epub 2019 Apr 5.

Division of Nephrology, Department of Medicine, Rush University Medical Center, Chicago, Illinois.

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.01920219
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http://dx.doi.org/10.2215/CJN.01920219DOI Listing
April 2019
10 Reads

A Person-Centered Prehabilitation Program Based on Cognitive-Behavioral Physical Therapy for Patients Scheduled for Lumbar Fusion Surgery - A Randomized Controlled Trial.

Phys Ther 2019 Feb 21. Epub 2019 Feb 21.

Department of Orthopaedics at Sahlgrenska Academy, Institute of the Clinical Sciences, University of Gothenburg; Department of Orthopaedics, Sahlgrenska University Hospital; Division of Physiotherapy, Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Box 455, 405 30 Göteborg, Sweden; and Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Background: Prehabilitation programs have led to improved postoperative outcomes in several surgical contexts, but there are presently no guidelines for the prehabilitation phase before lumbar fusion surgery.

Objective: The objective was to investigate whether a person-centered physiotherapeutic prehabilitation program, based on a cognitive-behavioral approach, reduces disability and improves functioning after lumbar fusion surgery more than conventional care does in patients with degenerative disc disease.

Design: This study was a randomized controlled trial. Read More

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http://dx.doi.org/10.1093/ptj/pzz020DOI Listing
February 2019
2 Reads

Development and application of a porcine specific ELISA for the quantification of soluble CD163.

Vet Immunol Immunopathol 2019 Apr 25;210:60-67. Epub 2019 Mar 25.

Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, 52 Campus Dr., University of Saskatchewan, Saskatoon, SK, S7N 5B4, Canada.

The cellular marker CD163 is a type 1 transmembrane scavenger protein found either on the surface of antigen-presenting cells or in a soluble form (sCD163), released in response to inflammation. Despite an obligatory role in porcine reproductive and respiratory virus (PRRSV) infection, information on sCD163 as a biomarker of disease outcome in swine remains limited. In the present study, we developed a sandwich ELISA using an anti-bovine CD163 antibody, LND68A, in conjunction with the porcine specific 2A10/11 antibody. Read More

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http://dx.doi.org/10.1016/j.vetimm.2019.03.011DOI Listing
April 2019
1 Read

Monitoring Kidney Dysfunction in Kugelberg-Welander Syndrome.

Am J Case Rep 2019 Apr 3;20:441-446. Epub 2019 Apr 3.

Kidney Transplant Program, St. Michael's Hospital, Toronto, Canada.

BACKGROUND Kugelberg-Welander (K-W) syndrome is a type of spinal muscular atrophy that causes weakness of the hip-girdle muscles. If severe enough, this weakness can confine patients to a wheelchair in adult life. Proteinuria, a manifestation of kidney dysfunction, is associated with disorders of many organ systems. Read More

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http://dx.doi.org/10.12659/AJCR.914458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459160PMC
April 2019
2 Reads

Validation of the Turkish version of the Urticaria Control Test: Correlation with other tools and comparison between spontaneous and inducible chronic urticaria.

World Allergy Organ J 2019 26;12(1):100009. Epub 2019 Jan 26.

Dermatological Allergology, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Germany.

Background: The urticaria control test (UCT) is a questionnaire designed to determine if chronic urticaria (CU) is controlled or not and to aid therapeutic decision-making. It collects retrospective information about the symptoms and quality of life impairment over the last 4 weeks. The current study aimed to investigate the validity, reliability and sensitivity to change of the Turkish version of the UCT. Read More

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http://dx.doi.org/10.1016/j.waojou.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439411PMC
January 2019
2 Reads

Efficacy and immunologic effects of extracorporeal photopheresis plus interleukin-2 in chronic graft-versus-host disease.

Blood Adv 2019 Apr;3(7):969-979

Division of Hematologic Malignancies, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA; and.

Chronic graft-versus-host disease (cGVHD) affects >50% of hematopoietic stem cell transplant patients. Extracorporeal photopheresis (ECP), an immunomodulatory therapy, provides clinical benefit in steroid-refractory (SR) cGVHD, possibly via regulatory T (T) and natural killer (NK) cell expansion. We demonstrated that low-dose interleukin-2 (IL2) led to clinical improvement in SR-cGVHD and stimulated preferential T and NK-cell expansion with minimal effect on conventional T (T) cells. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018029124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457231PMC
April 2019
1 Read

Duodenal mucosal resurfacing: proof-of-concept, procedural development, and initial implementation in the clinical setting.

Gastrointest Endosc 2019 Mar 29. Epub 2019 Mar 29.

Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. Electronic address:

Background And Aims: We aimed to develop duodenal mucosal resurfacing (DMR), a minimally invasive upper endoscopic hydrothermal ablation procedure, to treat insulin-resistant metabolic diseases.

Methods: We completed a sham-controlled, rodent proof-of-concept study and longitudinal safety study in pigs to demonstrate feasibility to test DMR in humans. Subsequently, the DMR procedure was implemented in an open-label first-in-human (FIH) study of safety and efficacy in patients with type 2 diabetes (T2D). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165107193021
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http://dx.doi.org/10.1016/j.gie.2019.03.024DOI Listing
March 2019
10 Reads

Manipulation of the Gut-Liver Axis Using Microbiome Restoration Therapy in Primary Sclerosing Cholangitis.

Am J Gastroenterol 2019 Mar 12. Epub 2019 Mar 12.

Division of Gastroenterology and Hepatology, University of Virginia Health System, Charlottesville, Virginia, USA.

Alteration of the normal gut-liver axis is important in primary sclerosing cholangitis (PSC). Lack of effective medical therapy for PSC makes microbiome restoration an alluring therapeutic target. Allegretti et al. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000191DOI Listing
March 2019
1 Read

Disseminated Intravascular Coagulation-like Reaction after Rituximab Infusion in a Patient with Nephrotic Syndrome: A Case Report.

Intern Med 2019 Mar 28. Epub 2019 Mar 28.

Division of Nephrology, Department of Medicine, Showa University Fujigaoka Hospital, Japan.

Several case series have suggested that rituximab is efficacious in adult patients with minimal change disease. We herein report a case of disseminated intravascular coagulation-like reaction after rituximab infusion in a patient with nephrotic syndrome. A 58-year-old Japanese man with minimal change disease diagnosed 15 years earlier was started on rituximab to prevent relapse of nephrotic syndrome when he presented to our clinic with low albuminemia, massive proteinuria, and leg edema. Read More

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http://dx.doi.org/10.2169/internalmedicine.2236-18DOI Listing
March 2019
1 Read

Reproducibility and responsiveness of gait initiation in Parkinson's disease.

J Biomech 2019 Apr 18;87:197-201. Epub 2019 Mar 18.

University of Utah, Department of Physical Therapy and Athletic Training, 520 Wakara Way, Salt Lake City, UT 84108, USA. Electronic address:

Persons with Parkinson's disease (PD) have significant impairments in functional mobility, including the ability to initiate gait. Three-dimensional analysis of kinetic and kinematic outcomes has become one of the most powerful tools in evaluating abnormalities in gait initiation for persons with PD. Surprisingly however, the psychometric properties of spatial and temporal measures of gait initiation for persons with PD have not been established using force-platforms. Read More

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http://dx.doi.org/10.1016/j.jbiomech.2019.03.009DOI Listing
April 2019
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Concerning "Acute kidney injury complicating nephrotic syndrome of minimal change disease".

Kidney Int 2019 Apr;95(4):993

Department of Pathology, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.12.009DOI Listing
April 2019
1 Read

Soluble Vascular Cell Adhesion Molecule-1 Is Associated With Disease Activity in Adult-Onset Minimal Change Disease.

Am J Med Sci 2019 Apr 2;357(4):311-315. Epub 2019 Feb 2.

Department of Nephrology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address:

Background: Cell adhesion molecules have been documented to be elevated in numerous immune inflammatory diseases. Minimal change disease (MCD) is an immune disorder. This study aimed to evaluate whether levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin) reflect disease activity in adult-onset MCD. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.01.017DOI Listing
April 2019
1 Read

Health-related quality of life in glomerular disease.

Kidney Int 2019 May 27;95(5):1209-1224. Epub 2019 Feb 27.

Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.

There is scant literature describing the effect of glomerular disease on health-related quality of life (HRQOL). The Cure Glomerulonephropathy study (CureGN) is an international longitudinal cohort study of children and adults with four primary glomerular diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy). HRQOL is systematically assessed using items from the Patient-Reported Outcomes Measurement Informative System (PROMIS). Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.018DOI Listing
May 2019
3 Reads

[Minimal change disease and focal segmental glomerulosclerosis].

Internist (Berl) 2019 Mar 18. Epub 2019 Mar 18.

Medizinische Klinik IV, Friedrich-Alexander-Universität Erlangen-Nürnberg, Ulmenweg 18, 91054, Erlangen, Deutschland.

Minimal change disease (MCD) or minimal change glomerulonephritis and focal segmental glomerulosclerosis (FSGS) are the two major causes of nephrotic syndrome in children and young adults. Both disease entities resemble each other and can sometimes only be discriminated on the basis of their clinical courses. MCD and FSGS display two classical examples that share a common pathophysiology in which the glomerular podocyte and the cytoskeleton of its foot processes play important roles. Read More

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http://dx.doi.org/10.1007/s00108-019-0590-yDOI Listing
March 2019
1 Read

Real world long-term impact of intensive treatment on disease activity, disability and health-related quality of life in rheumatoid arthritis.

BMC Rheumatol 2019 25;3. Epub 2019 Feb 25.

5Department of Rheumatology, Guy's and St Thomas' NHS Trust, 4th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London, UK.

Background: The emphasis on treating rheumatoid arthritis (RA) intensively reduces disease activity but its impact in routine care is uncertain. We evaluated temporal changes in disease activities and outcomes in a 10-year prospective observational cohort study of patients in routine care at one unit.

Methods: The Guy's and St Thomas' RA cohort was established in 2005. Read More

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http://dx.doi.org/10.1186/s41927-019-0054-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390620PMC
February 2019
1 Read

Achieving minimal disease activity in psoriatic arthritis predicts meaningful improvements in patients' health-related quality of life and productivity.

BMC Rheumatol 2018 13;2:24. Epub 2018 Aug 13.

6University of Leeds School of Medicine, Leeds, UK.

Background: Although psoriatic arthritis is complex and involves multiple domains, recent advances in treatments have made remission or near-remission of most symptoms a potentially achievable goal for many patients. We sought to evaluate whether achieving minimal disease activity (MDA) criteria represented meaningful improvement from the patient perspective.

Methods: Data were combined from two randomized, multinational, 24 week clinical studies of ixekizumab, a high-affinity monoclonal antibody selectively targeting interleukin-17A, in biological drug-naïve or experienced adults. Read More

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http://dx.doi.org/10.1186/s41927-018-0030-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390571PMC
August 2018
1 Read

Climate change may enable Aedes aegypti infestation in major European cities by 2100.

Environ Res 2019 Feb 16;172:693-699. Epub 2019 Feb 16.

Department of Mathematics and Mathematical Statistics, Umeå University, Umeå, Sweden; Evolution and Ecology Program, International Institute for Applied Systems Analysis, Laxenburg, Austria.

Background: Climate change allows Aedes aegypti to infest new areas. Consequently, it enables the arboviruses the mosquito transmits -- e.g. Read More

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http://dx.doi.org/10.1016/j.envres.2019.02.026DOI Listing
February 2019
1 Read

Long-term biological variation of high-sensitivity cardiac troponin T using minimal important differences and reference change values in stable outpatients with cardiovascular disease.

Clin Biochem 2019 May 11;67:7-11. Epub 2019 Mar 11.

Zentrum für Innere Medizin, Klinik für Kardiologie, Angiologie und Pneumologie, Universitätsklinikum Heidelberg, Germany.

Objective: To evaluate the long term biological variation of high-sensitivity cardiac troponin T (hs-cTnT) in stable outpatients with cardiovascular disease (CVD).

Methods: After applying 8 exclusion criteria to 965 patients, hs-cTnT was measured at index visit and at a 12-month interval in 169 stable outpatients presenting for routine follow-up visits for any CVD. Stability was defined as absence of any endpoint within the follow-up period. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2019.03.003DOI Listing
May 2019
1 Read

The effect of mobile personalised texting versus non-personalised texting on the caries risk of underprivileged adults: a randomised control trial.

BMC Oral Health 2019 Mar 12;19(1):44. Epub 2019 Mar 12.

Prosthodontics and Oral Rehabilitation, Cork Dental School and Hospital, University College Cork, Cork, Republic of Ireland.

Background: In the Republic of Ireland (RoI), fluoridation has been effective and efficient for caries prevention at population level, regardless of income status; however, at individual level it still has limitations. This study aimed to compare personalised versus non-personalised text messaging on 'chance of avoiding new cavities' with the Cariogram, a computer-based caries risk assessment (CRA) model, in an economically disadvantaged adult population in the RoI.

Methods: The intervention was via a CRA summary letter plus 24 weekly personalised mobile-phone short text messages (text messages) based on the individual's CRA, compared with a non-personalised approach via a non-personalised letter and a predetermined, fixed set of 24 weekly text messages. Read More

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http://dx.doi.org/10.1186/s12903-019-0729-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417196PMC
March 2019
1 Read

"If you can, change this system" -Pregnant asylum seekers' perceptions on social determinants and material circumstances affecting their health whilst living in state-provided accommodation in Germany - a prospective, qualitative case study.

BMC Public Health 2019 Mar 12;19(1):287. Epub 2019 Mar 12.

Department of General Practice & Health Services Research, Heidelberg University Hospital, Im Neuenheimer Feld 130.3, 69120, Heidelberg, Germany.

Background: Pregnant women and new mothers seeking asylum are highly vulnerable and have special needs, yet there is dearth of research related to this group in Germany. This paper reports on material circumstances and behavioural factors as social determinants of asylum seekers' health during pregnancy and early motherhood. The study aim was to gain in-depth insights into these women's experiences and perceived needs with a focus on material circumstances whilst living in state-provided accommodation in one federal state in Southern Germany. Read More

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http://dx.doi.org/10.1186/s12889-019-6481-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417255PMC
March 2019
1 Read

Effect of Resveratrol on biofilm formation and virulence factor gene expression of Porphyromonas gingivalis in periodontal disease.

APMIS 2019 Apr 12;127(4):187-195. Epub 2019 Mar 12.

Central Research Laboratory, Maratha Mandal's NGH Institute of Dental Sciences & Research Centre, Belgavi, Karnataka, India.

Periodontal disease is an oral inflammatory disease that destroys the tooth supporting periodontal tissues resulting in tooth loss. Porphyromonas gingivalis is a keystone pathogen that plays a significant role in periodontitis. In previous studies, resveratrol has shown significant results by targeting inflammatory and adhesive markers. Read More

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http://dx.doi.org/10.1111/apm.12930DOI Listing
April 2019
2 Reads

Sporadic Creutzfeldt-Jakob Disease in a Young Girl With Unusually Long Survival.

J Neuropathol Exp Neurol 2019 Apr;78(4):373-378

Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada.

Creutzfeldt-Jakob disease (CJD) is a rapidly progressive, fatal degenerative encephalopathy caused by a pathologically altered form of the prion protein (PrP). CJD is rare, with 1 and 2 cases per million per year reported in the general population, mostly in individuals over 50 years of age. It is almost unknown in the pediatric population. Read More

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http://dx.doi.org/10.1093/jnen/nlz013DOI Listing
April 2019
2 Reads

[Hypophysitis and retroperitoneal fibrosis associated with autoimmune polyglandular syndrome and IgG4-related disease. Report of one case].

Rev Med Chil 2018 Dec;146(12):1486-1492

Servicio de Medicina, Hospital Naval A. Nef., Viña del Mar, Chile.

We report a 23 year old woman presenting with a nephrotic syndrome due to minimal change disease, central diabetes insipidus, primary hypothyroidism, vitiligo and universal alopecia. Eleven years later, she presented secondary amenorrhea due to hypogonadotropic hypogonadism, with mild hyperprolactinemia and central adrenal insufficiency. A magnetic resonance imaging of the sella turcica showed a pituitary mass with suprasellar extension that was resected using a transsphenoidal approach. Read More

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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.4067/s0034-98872018001201486DOI Listing
December 2018
9 Reads
0.373 Impact Factor

Quantitative Assessment of Mucociliary Clearance in Smokers with Mild-to-Moderate Chronic Obstructive Pulmonary Disease and Chronic Bronchitis from Planar Radionuclide Imaging Using the Change in Penetration Index.

J Aerosol Med Pulm Drug Deliv 2019 Mar 8. Epub 2019 Mar 8.

7 Clinical Studies Sweden, Forum South, Skane University Hospital, Lund, Sweden.

Background: Mucociliary clearance (MCC) rate from the lung has been shown to be reduced in chronic obstructive pulmonary disease (COPD). This study compared the use of change in penetration index (PI) with conventional whole lung clearance in assessing MCC in mild-to-moderate disease.

Methods: Measurement of lung MCC using planar gamma camera imaging was performed in three groups: (1) healthy nonsmoking controls (n = 9), (2) smoking controls who were current smokers with normal lung function (n = 10), and (3) current smokers with mild-to-moderate COPD and bronchitis (n = 15). Read More

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http://dx.doi.org/10.1089/jamp.2017.1441DOI Listing
March 2019
1 Read

Paraneoplastic relapsing minimal change disease associated with type A thymoma in an elderly patient: A case report and literature review.

Med J Malaysia 2019 Feb;74(1):97-98

National University Health System, Department of Medicine, Singapore.

Thymoma is a rare mediastinal tumour that can be accompanied by different paraneoplastic syndromes. Here we report a case of Type A thymoma associated with relapsing minimal change disease (MCD). This case highlights: (1) The need to balance rapid prednisolone weaning against risk for relapse in an elderly patient at risk for steroid-induced complications. Read More

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February 2019
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Linking PANSS negative symptom scores with the Clinical Global Impressions Scale: understanding negative symptom scores in schizophrenia.

Neuropsychopharmacology 2019 Mar 5. Epub 2019 Mar 5.

Medical Division, Gedeon Richter Plc, Budapest, Hungary.

Understanding how rating scale improvement corresponds to a clinical impression in patients with negative symptoms of schizophrenia may help define the clinical relevance of change in this patient population. We conducted post hoc equipercentile linking analyses of Positive and Negative Syndrome Scale (PANSS) outcomes (e.g. Read More

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http://dx.doi.org/10.1038/s41386-019-0363-2DOI Listing
March 2019
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Electron microscopic findings suggestive of focal and segmental glomerulosclerosis in patients with steroid-resistant nephrotic syndrome.

Ultrastruct Pathol 2019 Mar 5:1-7. Epub 2019 Mar 5.

b Department of Pathology , Shahid Hasheminejad Hospital, Iran University of Medical Sciences , Tehran , I.R. Iran.

Distinction between minimal change disease and unsampled Focal Segmental Glomerulosclerosis is a challenging concept in kidney biopsy of patients with nephrotic syndrome with minimal histopathological findings. This study was performed to compare electron microscopic findings in patients with steroid-resistant nephrotic syndrome with minimal histopathological abnormalities and cases with Focal Segmental Glomerulosclerosis. This Cohort study was conducted in Cancer Institute, Imam Khomeini Hospital Complex, Tehran, Iran. Read More

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http://dx.doi.org/10.1080/01913123.2019.1584258DOI Listing
March 2019
2 Reads

Spectrum of biopsy proven renal disease in northern India: a single centre study.

Nephrology (Carlton) 2019 Mar 4. Epub 2019 Mar 4.

Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India-110029.

Aim: Pattern of kidney diseases varies across geographies due to multiple factors. There is a paucity of information from South Asia due to absence of nationwide/regional biopsy registries. This study aimed to delineate the spectrum of renal parenchymal diseases in our region. Read More

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http://doi.wiley.com/10.1111/nep.13582
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http://dx.doi.org/10.1111/nep.13582DOI Listing
March 2019
14 Reads

DTEXT - text messaging intervention to improve outcomes of people with type 2 diabetes: protocol for randomised controlled trial and cost-effectiveness analysis.

BMC Public Health 2019 Mar 4;19(1):262. Epub 2019 Mar 4.

University of Sydney, Sydney, Australia.

Background: Diabetes prevalence is rapidly increasing, with type 2 diabetes predicted to be the leading contributor of non-communicable disease in Australia by 2020. It is anticipated that rates of type 2 diabetes will continue to increase if factors such as overweight and obesity, low physical activity and poor nutrition are not addressed. The majority of Australians with type 2 diabetes do not meet the guidelines for optimal diabetes management, and access to diabetes education is limited. Read More

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http://dx.doi.org/10.1186/s12889-019-6550-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399841PMC
March 2019
2 Reads

Outcomes of Older Patients (≥60 years) with New-Onset Idiopathic Nephrotic Syndrome Receiving Immunosuppressive Regimen: A Multicentre Study of 116 Patients.

J Clin Med 2019 Mar 2;8(3). Epub 2019 Mar 2.

Département de Néphrologie et Transplantation d'Organes, Centre de Référence des Maladies Rénales Rares, Centre Hospitalier Universitaire de Toulouse, 31000 Toulouse, France.

Because of its rarity, renal presentation and outcomes of idiopathic nephrotic syndrome (INS; minimal changes disease or focal and segmental glomerulosclerosis) has poorly been described in elderly patients, precluding an individualized therapy procedure. Whether immunosuppressive regimens formerly designed in children and young adults are safe and efficient in elderly remains elusive. In a large multicentric retrospective study that included 116 patients with INS and onset ≥ 60 years of age, we showed that cumulative incidence of renal response was 95% after frontline therapy, with an age-dependent median time-to-response (60 days before 70 years of age at the onset vs. Read More

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https://www.mdpi.com/2077-0383/8/3/298
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http://dx.doi.org/10.3390/jcm8030298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463053PMC
March 2019
8 Reads