Neurology 2022 Apr 28. Epub 2022 Apr 28.
Divison of Neuroscience & Experimental Psychology, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, United Kingdom.
Background And Objectives: Disease-modifying therapeutic trials for genetic frontotemporal dementia (FTD) are underway, but sensitive cognitive outcome measures are lacking. The aim of this study was to identify such cognitive tests in early stage FTD by investigating firstly, cognitive decline in a large cohort of genetic FTD pathogenic variant carriers, and secondly, whether gene-specific differences are moderated by disease stage (asymptomatic, prodromal and symptomatic).
Methods: , and pathogenic variant carriers as well as controls underwent a yearly neuropsychological assessment covering eight cognitive domains, as part of the Genetic FTD Initiative (GENFI), a prospective multicenter cohort study. Read More