7,118 results match your criteria Minimal-Change Disease


Changing prevalence of current asthma and inhaled corticosteroid treatment in the UK: population based cohort 2006-2016.

Eur Respir J 2019 Feb 14. Epub 2019 Feb 14.

Population Health and Occupational Disease, NHLI, Imperial College London.

Background: Asthma is the most common respiratory disorder in the UK, yet we have incomplete knowledge on the prevalence of current disease, treatment and exacerbations.

Methods: We used UK electronic healthcare records, 2006-2016, to estimate the prevalence of current asthma by year, gender and age (<5, 5-11, 12-17, 18-24, 25-54 and ≥55 years), and the proportion prescribed inhaled corticosteroids (ICS) and additional asthma-therapy, treated for exacerbations and other asthma care markers.

Results: Overall current asthma prevalence was 6. Read More

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http://dx.doi.org/10.1183/13993003.02130-2018DOI Listing
February 2019

Longitudinal assessment of exercise capacity and quality of life outcome measures in cystic fibrosis: A year-long prospective pilot study.

J Eval Clin Pract 2019 Feb 13. Epub 2019 Feb 13.

Department of Pediatrics, Division of Pulmonology, Akron Children's Hospital, Akron, Ohio.

Background: Multiple outcomes measures including exercise capacity and quality of life are necessary to get complete and accurate picture of cystic fibrosis (CF) progression. In this pilot study, we investigated these measures in CF longitudinally for a year to determine (a) minimal clinically important difference (MCID) for 6-minute walk distance (6MWD) and CF Health-Related Quality of Life Questionnaire (CFQ-R) domains and (b) how 6MWD, CFQ-R, and spirometry change during times of exacerbation and baseline health and their relationship among each other.

Methods: Subjects with moderate and severe CF (baseline FEV less than 70% predicted) at Akron Children's Hospital CF centre were followed for a full year longitudinally. Read More

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http://dx.doi.org/10.1111/jep.13105DOI Listing
February 2019

Effectiveness of a 4-week rehabilitation program on endothelial function, blood vessel elasticity in patients with chronic obstructive pulmonary disease.

J Thorac Dis 2018 Dec;10(12):6482-6490

Department of Pulmonary Rehabilitation, National Koranyi Institute for Pulmonology, Budapest, Hungary.

Background: Chronic obstructive pulmonary disease (COPD) may have considerable cardiovascular risk. Physical activity has a paramount role in COPD treatment. Our aim was to evaluate the applicability of arteriograph in COPD and measure the effectiveness of pulmonary rehabilitation on endothelial function. Read More

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http://dx.doi.org/10.21037/jtd.2018.10.104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344670PMC
December 2018
1 Read

Renal toxicities associated with pembrolizumab.

Clin Kidney J 2019 Feb 9;12(1):81-88. Epub 2018 Nov 9.

Department of Pathology, Pitie-Salpetriere Hospital, Paris, France.

Objective: Expanded clinical experience with patients treated by pembrolizumab has accumulated. However, renal toxicities associated with this anti-programmed cell death 1 agent are poorly described because kidney histology is rarely sought. As a nephrology referral centre, we aimed to describe the clinic-biological and histopathological characteristics of pembrolizumab-related nephropathy and its response to treatment. Read More

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http://dx.doi.org/10.1093/ckj/sfy100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366307PMC
February 2019
1 Read

Does weight loss reduce the severity and incidence of psoriasis or psoriatic arthritis? A critically-appraised topic.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Clinical Question: Does weight loss reduce the severity and incidence of psoriasis or psoriatic arthritis (PsA) in obese individuals?

Background: Obesity presents a rising public health challenge and is more prevalent amongst individuals with psoriasis or PsA compared to the general population. Longitudinal population-based studies suggest a causal role for obesity in psoriasis and PsA onset and that obesity drives greater disease severity.

Methods: We systematically reviewed evidence within Medline/EMBASE/CENTRAL databases and clinical trials registries examining lifestyle, pharmacological and surgical weight loss interventions in the treatment and prevention of psoriasis and PsA in obese individuals. Read More

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http://dx.doi.org/10.1111/bjd.17741DOI Listing
February 2019
3 Reads

Effectiveness of an integrated diabetes care package at primary healthcare facilities: a cluster randomised trial in Pakistan.

BJGP Open 2018 Dec 12;2(4):bjgpopen18X101618. Epub 2018 Dec 12.

Senior Advisor, Department of Research, International Union Against Tuberculosis and Lung Disease, Winchester, UK.

Background: There were an estimated 7 million people living with diabetes in Pakistan in 2014, and this is predicted to reach 11.4 million by 2030.

Aim: To assess if an integrated care package can achieve better control of diabetes. Read More

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http://dx.doi.org/10.3399/bjgpopen18X101618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348328PMC
December 2018
3 Reads

Direct oral anticoagulant successfully used to treat an adult nephrotic patient complicated with portal vein thrombosis.

CEN Case Rep 2019 Feb 5. Epub 2019 Feb 5.

Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Tokushima, Japan.

Thromboembolism is a major complication of nephrotic syndrome, with the renal vein being the most frequent site. However, the incidence of portal vein thrombosis (PVT) in patients with nephrotic syndrome is rare. We report a case of a relapsed steroid-dependent minimal change disease with incidental PVT. Read More

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http://dx.doi.org/10.1007/s13730-019-00381-9DOI Listing
February 2019
1 Read

Trial to Encourage Adoption and Maintenance of a Mediterranean Diet (TEAM-MED): Protocol for a Randomised Feasibility Trial of a Peer Support Intervention for Dietary Behaviour Change in Adults at High Cardiovascular Disease Risk.

Int J Environ Res Public Health 2018 May 31;15(6). Epub 2018 May 31.

Centre for Public Health, Queen's University Belfast, Grosvenor Road, Belfast BT12 6BJ, UK.

Adoption of a Mediterranean diet (MD) reduces cardiovascular disease (CVD) risk. However, interventions to achieve dietary behaviour change are typically resource intensive. Peer support offers a potentially low-cost approach to encourage dietary change. Read More

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http://dx.doi.org/10.3390/ijerph15061130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025132PMC
May 2018
2 Reads

Psychometric properties of the Spanish version of the once-daily Urticaria Activity Score (UAS) in patients with chronic spontaneous urticaria managed in clinical practice (the EVALUAS study).

Health Qual Life Outcomes 2019 Jan 31;17(1):23. Epub 2019 Jan 31.

Allergy Unit, Pneumology Department, Hospital Clinic, University of Barcelona, Barcelona, Spain.

Background: The daily diary Urticaria Activity Score (UAS) and its weekly score (UAS7) are widely used to assess signs and symptoms in patients with chronic spontaneous urticaria (CSU). The objective of this study was to assess the psychometric properties of a Spanish version of the once-daily UAS.

Methods: Observational study in patients ≥18 years old receiving usual care for CSU (daily or almost daily occurrence of generalized hives or angioedema for ≥6 weeks). Read More

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http://dx.doi.org/10.1186/s12955-019-1087-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357477PMC
January 2019
1 Read

Diagnostics and treatment challenges of Ph-like acute lymphoblastic leukemia: a description of 3 clinical cases.

Ter Arkh 2018 Aug;90(7):110-117

National Research Center for Hematology, Moscow, Russia.

B-cell acute lymphoblastic leukemia (B-ALL) is a diverse group of malignant blood disorders both with regard to the biological properties of the tumor and to therapeutic approaches. Immunophenotyping, molecular genetic techniques, whole-genome sequencing characterize B-ALL as a very diverse group for sensitivity to chemotherapy and prognosis. We present three clinical cases of patients with B-ALL and expected good response to standard therapy, in whom standard protocol treatment failured: refractoriness, persistence of minimal residual disease (MRD), and progression (MRD increase). Read More

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http://dx.doi.org/10.26442/terarkh2018907110-117DOI Listing
August 2018
1 Read

TDP43 pathology in the brain, spinal cord, and dorsal root ganglia of a patient with FOSMN.

Neurology 2019 Jan 30. Epub 2019 Jan 30.

From the MRC Centre for Neuromuscular Diseases (A.M.R., M.M.R.), Department of Neurodegenerative Disease (Z.J.), Queen Square Brain Bank (Z.J., G.H.), and Dementia Research Centre (M.N.R.), UCL Institute of Neurology; National Hospital for Neurology and Neurosurgery (A.M.R., M.M.R., M.N.R.); and Division of Neuropathology (Z.J.), National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, UK.

Objective: To describe the histopathologic features of a case of facial-onset sensory and motor neuronopathy (FOSMN).

Methods: We describe a postmortem examination performed on a 54-year-old man with FOSMN associated with personality change.

Results: Postmortem examination revealed TAR DNA-binding protein (TDP) 43 proteinopathy with widespread distribution. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007008DOI Listing
January 2019
3 Reads

Impact of tricuspid annular size reduction on right ventricular function, geometry and strain.

Eur J Cardiothorac Surg 2019 Jan 29. Epub 2019 Jan 29.

Division of Cardiothoracic Surgery, Spectrum Health, Grand Rapids, MI, USA.

Objectives: Restrictive tricuspid annuloplasty is a clinically accepted approach to treat functional tricuspid regurgitation. We set out to investigate the effect of varying degrees of tricuspid annular reduction on the right ventricular (RV) function, geometry and strain.

Methods: Eight, healthy sheep (45 ± 4 kg) had 6 sonomicrometry crystals implanted around the tricuspid annulus and 20 onto the epicardium of the right ventricle defining 3 free wall regions: basal, mid and lower. Read More

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http://dx.doi.org/10.1093/ejcts/ezy484DOI Listing
January 2019
2 Reads

Structural Perspective on Revealing and Altering Molecular Functions of Genetic Variants Linked with Diseases.

Int J Mol Sci 2019 Jan 28;20(3). Epub 2019 Jan 28.

Department of Physics and Astronomy, Clemson University, Clemson, SC 29634, USA.

Structural information of biological macromolecules is crucial and necessary to deliver predictions about the effects of mutations-whether polymorphic or deleterious (i.e., disease causing), wherein, thermodynamic parameters, namely, folding and binding free energies potentially serve as effective biomarkers. Read More

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http://www.mdpi.com/1422-0067/20/3/548
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http://dx.doi.org/10.3390/ijms20030548DOI Listing
January 2019
4 Reads

Acute Kidney Injury in Nephrotic Syndrome.

Authors:
Shina Menon

Front Pediatr 2018 14;6:428. Epub 2019 Jan 14.

Division of Nephrology, Department of Pediatrics, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, WA, United States.

Nephrotic syndrome (NS) is one of the commonest kidney diseases seen in childhood and is characterized by a relapsing remitting course. Various complications have been reported in children with NS, including infections, thromboembolism, hypovolemia, and acute kidney injury (AKI). There is often a modest decrease in renal function in patients with active proteinuria due to decreased glomerular permeability that improves when they go into remission. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00428/
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http://dx.doi.org/10.3389/fped.2018.00428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340287PMC
January 2019
4 Reads

Cognitive screening in chronic obstructive pulmonary disease: patient's perspectives.

Disabil Rehabil 2019 Jan 26:1-7. Epub 2019 Jan 26.

c Improving Palliative , Aged and Chronic Care through Clinical Trials Centre , The University of Technology Sydney , Sydney , Australia.

Purpose: Cognitive impairment is highly prevalent (61%) in chronic obstructive pulmonary disease (COPD). International guidelines recommend providing self-management education through resource-intensive, pulmonary rehabilitation programs, yet screening for deficits likely to interfere with learning have received insufficient attention. Concerns over cognitive testing as confronting are described by health professionals as a barrier to screening, but with minimal empiric data. Read More

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http://dx.doi.org/10.1080/09638288.2018.1519046DOI Listing
January 2019
10 Reads

Is True Whole-body FDG-PET/CT required in paediatric lymphoma? An IAEA Multicentre Prospective Study.

J Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

International Atomic Energy Agency, Austria.

Guidelines recommend true whole body (TWB) FDG-PET/CT scans from vertex to toes in paediatric lymphoma patients, although this suggestion has not been validated in large clinical trials. The objective of the study is to evaluate the incidence and clinical impact of lesions outside the "eyes to thighs" regular field of view (R-FOV) in FDG-PET/CT staging (sPET) and interim (iPET) scans in paediatric lymphoma patients. TWB sPET and iPET scans were prospectively performed in paediatric lymphoma patients (11 worldwide centres). Read More

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http://dx.doi.org/10.2967/jnumed.118.222299DOI Listing
January 2019
3 Reads

A Modular Health-Related Quality of Life Instrument for Electronic Assessment and Treatment Monitoring: Web-Based Development and Psychometric Validation of Core Thrive Items.

J Med Internet Res 2019 Jan 25;21(1):e12075. Epub 2019 Jan 25.

PatientsLikeMe, Cambridge, MA, United States.

Background: Patient-reported outcome (PRO) measures describe natural history, manage disease, and measure the effects of interventions in trials. Patients themselves increasingly use Web-based PRO tools to track their progress, share their data, and even self-experiment. However, existing PROs have limitations such as being: designed for paper (not screens), long and burdensome, negatively framed, under onerous licensing restrictions, either too generic or too specific. Read More

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http://dx.doi.org/10.2196/12075DOI Listing
January 2019
2 Reads

Effect of calories-only vs physical activity calorie expenditure labeling on lunch calories purchased in worksite cafeterias.

BMC Public Health 2019 Jan 23;19(1):107. Epub 2019 Jan 23.

Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, USA.

Background: Calorie labeling on restaurant menus is a public health strategy to guide consumer ordering behaviors, but effects on calories purchased have been minimal. Displaying labels communicating the physical activity required to burn calories may be a more effective approach, but real-world comparisons are needed.

Methods: In a quasi-experimental study, we examined the effect of physical activity calorie expenditure (PACE) food labels compared to calorie-only labels on point-of-decision food purchasing in three worksite cafeterias in North Carolina. Read More

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http://dx.doi.org/10.1186/s12889-019-6433-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343240PMC
January 2019
2 Reads

Predictors of Short-Term Prognosis While in Pediatric Headache Care: An Observational Study.

Headache 2019 Jan 23. Epub 2019 Jan 23.

Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Objectives: To characterize the short-term prognosis of a clinical population of pediatric and young adult patients with migraine and explore predictors of clinical worsening while in care.

Methods: This was a retrospective study of all migraine patients seen at the Cincinnati Children's Hospital Headache Center from 09/01/2006 to 12/31/2017, who had at least 1 follow-up visit within 1-3 months of the index visit analyzed. Included data were: age, sex, race, primary ICHD diagnosis, chronic migraine, medication overuse, history of status migrainosus, BMI percentile, headache frequency, headache severity, PedMIDAS score, allodynia, preventive treatment type, lifestyle habits, disease duration, depressive and anxiety symptoms. Read More

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http://dx.doi.org/10.1111/head.13477DOI Listing
January 2019
1 Read

Effect of a Low Free Sugar Diet vs Usual Diet on Nonalcoholic Fatty Liver Disease in Adolescent Boys: A Randomized Clinical Trial.

JAMA 2019 01;321(3):256-265

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Emory University, Atlanta, Georgia.

Importance: Pediatric guidelines for the management of nonalcoholic fatty liver disease (NAFLD) recommend a healthy diet as treatment. Reduction of sugary foods and beverages is a plausible but unproven treatment.

Objective: To determine the effects of a diet low in free sugars (those sugars added to foods and beverages and occurring naturally in fruit juices) in adolescent boys with NAFLD. Read More

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http://dx.doi.org/10.1001/jama.2018.20579DOI Listing
January 2019
7 Reads

Management and treatment of glomerular diseases (part 2): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kidney Int 2019 Feb;95(2):281-295

Division of Nephrology, Rheinisch-Westfälische Technische Hochschule, University of Aachen, Aachen, Germany. Electronic address:

In November 2017, the Kidney Disease: Improving Global Outcomes (KDIGO) initiative brought a diverse panel of experts in glomerular diseases together to discuss the 2012 KDIGO glomerulonephritis guideline in the context of new developments and insights that had occurred over the years since its publication. During this KDIGO Controversies Conference on Glomerular Diseases, the group examined data on disease pathogenesis, biomarkers, and treatments to identify areas of consensus and areas of controversy. This report summarizes the discussions on primary podocytopathies, lupus nephritis, anti-neutrophil cytoplasmic antibody-associated nephritis, complement-mediated kidney diseases, and monoclonal gammopathies of renal significance. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.008DOI Listing
February 2019
1 Read

The minimal detectable difference for endurance shuttle walk test performance in people with COPD on completion of a program of high-intensity ground-based walking.

Respir Med 2019 Jan 20;146:18-22. Epub 2018 Nov 20.

Discipline of Physiotherapy, Faculty of Health Sciences, The University of Sydney, New South Wales, Australia; Sydney Local Health District, New South Wales, Australia.

Background: In people with moderate-to-severe chronic obstructive pulmonary disease (COPD), the minimal detectable difference (MDD) in endurance shuttle walk test (ESWT) performance following exercise training is unclear. We sought to determine the MDD for ESWT performance following supervised ground-based walking training using anchor- and distribution-based approaches and report whether these values exceeded random variation in test performance.

Methods: Participants with COPD trained for 30-45 min, 2-3 times weekly for 8-10 weeks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09546111183037
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http://dx.doi.org/10.1016/j.rmed.2018.11.013DOI Listing
January 2019
4 Reads

MeSsAGe risk score: tool for renal biopsy decision in steroid-dependent nephrotic syndrome.

Pediatr Res 2019 Jan 15. Epub 2019 Jan 15.

Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Level 12 NUHS Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.

Background: A lack of consensus exists as to the timing of kidney biopsy in children with steroid-dependent nephrotic syndrome (SDNS) where minimal change disease (MCD) predominates. This study aimed at examining the applicability of a biomarker-assisted risk score model to select SDNS patients at high risk of focal segmental glomerulosclerosis (FSGS) for biopsy.

Methods: Fifty-five patients with SDNS and biopsy-proven MCD (n = 40) or FSGS (n = 15) were studied. Read More

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http://www.nature.com/articles/s41390-019-0277-z
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http://dx.doi.org/10.1038/s41390-019-0277-zDOI Listing
January 2019
6 Reads
2.314 Impact Factor

Distinct skeletal muscle molecular responses to pulmonary rehabilitation in chronic obstructive pulmonary disease: a cluster analysis.

J Cachexia Sarcopenia Muscle 2019 Jan 18. Epub 2019 Jan 18.

Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.

Background: Pulmonary rehabilitation (PR) is a cornerstone in the management of chronic obstructive pulmonary disease (COPD), targeting skeletal muscle to improve functional performance. However, there is substantial inter-individual variability in the effect of PR on functional performance, which cannot be fully accounted for by generic phenotypic factors. We performed an unbiased integrative analysis of the skeletal muscle molecular responses to PR in COPD patients and comprehensively characterized their baseline pulmonary and physical function, body composition, blood profile, comorbidities, and medication use. Read More

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http://dx.doi.org/10.1002/jcsm.12370DOI Listing
January 2019
1 Read

Minimal Clinically Important Differences for the Modified Rodnan Skin Score: Results from the Scleroderma Lung Studies (SLS-I and SLS-II).

Arthritis Res Ther 2019 Jan 16;21(1):23. Epub 2019 Jan 16.

Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, USA.

Objective: This study aimed to assess the minimal clinically important differences (MCIDs) for the modified Rodnan skin score (mRSS) using combined data from the Scleroderma Lung Studies (I and II).

Methods: MCID estimates for the mRSS at 12 months were calculated using three anchors: change in scores on the Health Assessment Questionnaire- Disability Index from baseline to 12 months, change in scores on the Patient Global Assessment from baseline to 12 months, and answer at 12 month for the Short Form-36 health transition question "Compared to one year ago, how would you rate your health in general now?" We determined the mRSS MCID estimates for all participants and for those with diffuse cutaneous systemic sclerosis (dcSSc). We then assessed associations between MCID estimates of mRSS improvement and patient-reported outcomes, using Student's t test to compare the mean differences in patient outcomes between those who met the MCID improvement criteria versus those who did not meet the improvement criteria. Read More

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http://dx.doi.org/10.1186/s13075-019-1809-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335851PMC
January 2019
1 Read

Therapeutic Inhibition of VEGF Signaling and Associated Nephrotoxicities.

J Am Soc Nephrol 2019 Feb 14;30(2):187-200. Epub 2019 Jan 14.

Division of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, New York; and

Inhibition of vascular endothelial growth factor A (VEGFA)/vascular endothelial growth factor receptor 2 (VEGFR2) signaling is a common therapeutic strategy in oncology, with new drugs continuously in development. In this review, we consider the experimental and clinical evidence behind the diverse nephrotoxicities associated with the inhibition of this pathway. We also review the renal effects of VEGF inhibition's mediation of key downstream signaling pathways, specifically MAPK/ERK1/2, endothelial nitric oxide synthase, and mammalian target of rapamycin (mTOR). Read More

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http://dx.doi.org/10.1681/ASN.2018080853DOI Listing
February 2019
1 Read

Translating treatment effects between rheumatoid arthritis activity measures and American College of Rheumatology responses in direct comparison trials.

Arthritis Care Res (Hoboken) 2019 Jan 10. Epub 2019 Jan 10.

Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health.

Objective: Direct comparison trials in rheumatoid arthritis (RA) increasingly use changes in continuous disease activity measures as endpoints. However, the between-arm differences in these scores that are clinically meaningful are uncertain. To aid interpretation of clinical trials that use the Disease Activity Score 28 (DAS28) or Simplified Disease Activity Index (SDAI) as endpoints, we developed statistical equivalences between changes in these measures and American College of Rheumatology (ACR) responses. Read More

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http://doi.wiley.com/10.1002/acr.23825
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http://dx.doi.org/10.1002/acr.23825DOI Listing
January 2019
7 Reads

Peripapillary capillary vessel density progression in advanced glaucoma: a case report.

Authors:
Gábor Holló

BMC Ophthalmol 2019 Jan 5;19(1). Epub 2019 Jan 5.

Department of Ophthalmology, Semmelweis University, Mária u. 39, Budapest, 1085, Hungary.

Background: We report a case of advanced juvenile open-angle glaucoma (JOAG) in which peripapillary capillary vessel density (PcVD) in the inferior retina showed significant progression while the spatially corresponding retinal nerve fiber layer thickness (RNFLT) and visual field cluster defect values had reached their minimal detectable values, and showed no change during the follow-up (floor effect).

Case Presentation: A 45-year old white female patient with very advanced under treatment JOAG in the left eye was prospectively investigated with the AngioVue OCT (Optovue Inc., Fremont, USA) for RNFLT and PcVD, and Octopus Normal G2 visual field testing, at 6-month intervals for 2. Read More

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http://dx.doi.org/10.1186/s12886-018-1021-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321677PMC
January 2019
2 Reads

Inhibition of radiographic progression in psoriatic arthritis by adalimumab independent of the control of clinical disease activity.

Rheumatology (Oxford) 2019 Jan 3. Epub 2019 Jan 3.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Objectives: To evaluate the relationship between radiographic progression and disease activity in subjects with PsA treated with adalimumab (ADA) or placebo (PBO) and the impact of concomitant MTX.

Methods: This was a post hoc analysis of the randomized, double-blind, PBO-controlled ADEPT trial. Subjects were categorized according to time-averaged (TA) disease activity (remission, low, moderate or high) based on Disease Activity Score of 28 joints with CRP [DAS28(CRP)], Disease Activity Index for Psoriatic Arthritis (DAPSA) or Psoriatic Arthritis Disease Activity Score (PASDAS), and achievement of minimal disease activity (MDA) at week 24. Read More

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/key417DOI Listing
January 2019
3 Reads

Retrospective assessment of the quality of diabetes care in a rural diabetes clinic in Western Kenya.

BMC Endocr Disord 2018 Dec 27;18(1):97. Epub 2018 Dec 27.

Moi University School of Medicine, Nandi Hills Road, Eldoret, 30100, Kenya.

Background: Sub-Saharan Africa continues to face the highest rate of mortality from diabetes in the world due to limited access to quality diabetes care. We assessed the quality of diabetes care in a rural diabetes clinic in western Kenya.

Methods: To provide a comprehensive assessment, a set of clinical outcomes, process, and structure metrics were evaluated to assess the quality of diabetes care provided in the outpatient clinic at Webuye District Hospital. Read More

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http://dx.doi.org/10.1186/s12902-018-0324-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307239PMC
December 2018
3 Reads

Clinicopathological profile of pediatric renal biopsies at a tertiary care hospital, Pakistan.

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1403-1409

The Kidney Center, Karachi, Pakistan.

Renal biopsy is an important tool for the diagnosis of acute and chronic glomerular diseases in children. We aimed to analyze the spectrum of clinical indications and histopathological patterns (HPP) in children who underwent renal biopsy (RB). This is a retrospective review of case records of 108 renal biopsies carried out from January 2010 to December 2015 at the Pediatric Nephrology Department, National Institute of Child Health Karachi, Pakistan. Read More

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http://www.sjkdt.org/text.asp?2018/29/6/1403/248290
Publisher Site
http://dx.doi.org/10.4103/1319-2442.248290DOI Listing
December 2018
13 Reads

Spectrum of glomerular diseases in Arab countries: A systematic review.

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1256-1266

Department of Allied Health Sciences, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.

According to the best of our knowledge, there is no review compiling incidence of glomerular disease in all Arab countries. Most of the Arab countries do not have a national renal biopsy registry. In addition, there is scanty data available on the epidemiology of glomerular diseases in Arab countries. Read More

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http://www.sjkdt.org/text.asp?2018/29/6/1256/248285
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http://dx.doi.org/10.4103/1319-2442.248285DOI Listing
December 2018
7 Reads

Persistent CD-19 Depletion by Rituximab is Cost-effective in Maintaining Remission in Calcineurin-inhibitor Dependent Podocytopathy.

Nephrology (Carlton) 2018 Dec 26. Epub 2018 Dec 26.

Department of Nephrology, PGIMER, Chandigarh.

Aim: A significant proportion of patients with minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are either steroid dependent (SD) or resistant (SR), requiring long-term calcineurin inhibitors (CNIs) use. Rituximab has more favourable safety profile. The present study was undertaken to evaluate the efficacy and safety of rituximab in CNI dependent patients. Read More

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http://dx.doi.org/10.1111/nep.13554DOI Listing
December 2018
1 Read

Minimal change disease: A case report.

Authors:

Nursing 2019 Jan;49(1):37-38

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http://dx.doi.org/10.1097/01.NURSE.0000552823.13295.89DOI Listing
January 2019
1 Read

Participation in a single-blinded pediatric therapeutic strategy study for juvenile idiopathic arthritis: are parents and patient-participants in equipoise?

BMC Med Ethics 2018 12 20;19(1):96. Epub 2018 Dec 20.

Department of Medical Ethics and Health Law, Leiden University Medical Center, Leiden, the Netherlands.

Background: Genuine uncertainty on superiority of one intervention over the other is called equipoise. Physician-investigators in randomized controlled trials (RCT) need equipoise at least in studies with more than minimal risks. Ideally, this equipoise is also present in patient-participants. Read More

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http://dx.doi.org/10.1186/s12910-018-0336-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302476PMC
December 2018
2 Reads

Pimavanserin in Alzheimer's Disease Psychosis: Efficacy in Patients with More Pronounced Psychotic Symptoms.

J Prev Alzheimers Dis 2019 ;6(1):27-33

Clive Ballard, MBChB, Institute of Health Research, University of Exeter Medical School, Exeter EX1 2LU, UK,

Background: Pimavanserin is a 5-HT2A receptor inverse agonist/antagonist and is approved in the United States for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis.

Objective: Evaluate the efficacy of pimavanserin on symptoms of psychosis in patients with Alzheimer's disease (AD).

Design: Randomized, double-blind, placebo-controlled trial. Read More

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http://dx.doi.org/10.14283/jpad.2018.30DOI Listing
January 2019
15 Reads

Overproduction of Mitochondrial Fission Proteins in Membranous Nephropathy in Children.

Kidney Blood Press Res 2018 14;43(6):1927-1934. Epub 2018 Dec 14.

Department of Biostatistics, Peking University First Hospital, Beijing, China.

Background/aims: The molecules involved in nephrotic syndrome (NS) have not been fully clarified. Mitochondrial fission proteins are found to be involved in podocyte injury in vitro. Increased glomerular expression of mitochondrial fission proteins was found in adriamycin nephropathy in our previous study. Read More

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http://dx.doi.org/10.1159/000496006DOI Listing
December 2018
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Prenatal exposure to PCBs in Cyp1a2 knock-out mice interferes with F fertility, impairs long-term potentiation, reduces acoustic startle and impairs conditioned freezing contextual memory with minimal transgenerational effects.

J Appl Toxicol 2018 Dec 18. Epub 2018 Dec 18.

Department of Pediatrics, University of Cincinnati College of Medicine, and Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH, 45229, USA.

Polychlorinated biphenyls (PCBs) are toxic environmental pollutants. Humans are exposed to PCB mixtures via contaminated food or water. PCB exposure causes adverse effects in adults and after exposure in utero. Read More

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http://dx.doi.org/10.1002/jat.3751DOI Listing
December 2018
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Vitamin D deficiency in patients with stages 1 and 2 chronic kidney disease in Southern China.

Niger J Clin Pract 2018 Dec;21(12):1639-1644

Department of Nephrology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Aim: We aim to investigate the incidence and associated factors of vitamin D deficiency, a seldom reported factor, in patients with stages 1 and 2 chronic kidney disease (CKD) in southern China.

Methods: We conducted a single-center observational study. Hospitalized patients over 14 years old, who were diagnosed with stages 1 and 2 CKD and had their serum 25-hydroxyvitamin D [25 (OH) D] measured, were included. Read More

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http://dx.doi.org/10.4103/njcp.njcp_158_18DOI Listing
December 2018
1 Read

Short-Term Steroid Regimen for Adult Steroid-Sensitive Minimal Change Disease.

Am J Nephrol 2019 17;49(1):54-63. Epub 2018 Dec 17.

Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya,

Background: In pediatric patients with steroid-sensitive nephrotic syndrome, recent trials have revealed that a 2-month, short-term steroid regimen is not inferior to an extended steroid course. However, the optimal duration of initial steroid therapy for adult steroid-sensitive minimal change disease (MCD) remains unclear.

Objectives: The aim of present study was to evaluate the effectiveness of a 2-month, short-term steroid regimen in the treatment of adult steroid-sensitive MCD patients. Read More

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http://dx.doi.org/10.1159/000495352DOI Listing
December 2018
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Impact of cerebral blood flow changes due to arterial bypass surgery on cognitive function in adult patients with symptomatic ischemic moyamoya disease.

J Neurosurg 2018 Dec 14:1-9. Epub 2018 Dec 14.

1Department of Neurosurgery and.

OBJECTIVESome adult patients with moyamoya disease (MMD) undergoing revascularization surgery show an improvement or decline in cognition postoperatively. Revascularization surgery for ischemic MMD augments cerebral blood flow (CBF) and improves cerebral oxygen metabolism. However, cerebral hyperperfusion, which is a short-term, major increase in ipsilateral CBF that is much greater than the metabolic needs of the brain, sometimes occurs as a complication. Read More

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http://dx.doi.org/10.3171/2018.7.JNS18149DOI Listing
December 2018

Minimal Change Disease Associated with High-dose Aspirin.

Cureus 2018 Oct 4;10(10):e3408. Epub 2018 Oct 4.

Nephrology, North Florida Regional Medical Center, Gainesville, USA.

Minimal change disease (MCD) is an etiology of nephrotic syndrome that is more common in the pediatric population as compared to the adult population. Steroids are an effective treatment for MCD. Non-steroidal anti-inflammatory drugs (NSAIDS) are well known for their nephrotoxicity when used chronically. Read More

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http://dx.doi.org/10.7759/cureus.3408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284872PMC
October 2018

The elevated levels of urinary angiotensinogen are correlated with the severity of idiopathic membranous nephropathy.

BMC Nephrol 2018 Dec 12;19(1):357. Epub 2018 Dec 12.

Department of Nephrology, Peking University Third Hospital, No. 49, North Garden Road, Haidian District, Beijing, 100191, China.

Background: Immunosuppressive treatment will predispose an idiopathic membranous nephropathy (iMN) patient to opportunistic infections. Disease severity is one of the main concerns for making the treatment decision. Urinary angiotensinogen (UAGT) level has been shown highly correlated with intrarenal renin-angiotensin system (RAS) activity and severity of chronic kidney diseases (CKD). Read More

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http://dx.doi.org/10.1186/s12882-018-1165-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291953PMC
December 2018
1 Read

[Role of cofilin in kidney disease].

Authors:
Xiejia Li Hong Liu

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Oct;43(10):1159-1163

Department of Nephrology, Second Xiangya Hospital, Central South University; Hunan Key Laboratory of Kidney Disease and Blood Purifi cation, Changsha 410011, China.

Cofilin is a actin-binding protein in eukaryotic cells. It plays a role in maintaining the steady state of the internal environment through regulating actin dynamics, which contributes to the development of various kinds of diseases. In recent 20 years, cofilin has been widely attracted due to its regulatory effect on cell phenotype, gene transcription, apoptosis and inflammation in renal tissue. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.10.018DOI Listing
October 2018
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Targeted Therapies in CLL: Monotherapy Versus Combination Approaches.

Curr Hematol Malig Rep 2018 Dec;13(6):525-533

Department of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, 1500 E. Duarte Rd., Duarte, CA, 91010, USA.

Purpose Of Review: While chemoimmunotherapy has improved outcomes in chronic lymphocytic leukemia (CLL), it is not curative, has significant relapse rates, and is not always well tolerated. Recently, novel targeted therapies have been developed to increase response rates and reduce toxicity, especially in high-risk disease. Current goals of CLL therapies are to produce deep and durable, especially minimal residual disease (MRD)-negative, remissions so as to allow patients to ultimately discontinue treatment for a while. Read More

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http://link.springer.com/10.1007/s11899-018-0481-7
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http://dx.doi.org/10.1007/s11899-018-0481-7DOI Listing
December 2018
13 Reads

Short-Term Clinical Outcomes and Safety Associated With Percutaneous Radiofrequency Treatment for Excessive Sweating.

Aesthet Surg J 2018 Dec 9. Epub 2018 Dec 9.

Plastic surgeon in private practice in Osaka City, Japan.

Background: Primary excessive sweating of the axilla affects approximately 3.12% of the US population and has a negative impact on individuals' lives.

Objectives: We report the safety and effectiveness up to 90 days after treating excessive sweating with percutaneous radiofrequency when using a standardized protocol. Read More

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http://dx.doi.org/10.1093/asj/sjy277DOI Listing
December 2018
5 Reads

Immunoglobulin E and G Levels in Predicting Minimal Change Disease before Renal Biopsy.

Biomed Res Int 2018 11;2018:3480309. Epub 2018 Nov 11.

Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Purpose: The diagnosis of minimal change disease in adults relies mainly on renal biopsy, but this procedure is not without complications. Despite the advancements in technique of percutaneous renal biopsy, biopsy-related complications still occur. Bleeding is one of the major complications, which may lead to hemodynamic instability and, sometimes, even death. Read More

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http://dx.doi.org/10.1155/2018/3480309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252198PMC
November 2018
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Minimal change disease: A case report.

Nursing 2019 Jan;49(1):32-37

At California State University, Chico, Fay Mitchell-Brown is an associate professor and Tiernan Veisze is a senior nursing student. Dr. Mitchell-Brown teaches pathophysiology and is a practicing critical care nurse.

Although minimal change disease (MCD) is a major cause of nephrotic syndrome in children, it's less common in adults. It develops from damage to the glomeruli with a loss of large amounts of protein in the urine. Early recognition and treatment is the key to a good outcome. Read More

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http://dx.doi.org/10.1097/01.NURSE.0000549719.61573.cdDOI Listing
January 2019
2 Reads