8,059 results match your criteria Minimal-Change Disease


A Multicenter Pilot Randomized Clinical Trial of a Home-Based Exercise Program for Patients With Cirrhosis: The Strength Training Intervention (STRIVE).

Am J Gastroenterol 2021 Apr;116(4):717-722

1Department of Medicine, University of California-San Francisco, San Francisco, California, USA; 2Division of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA; 3Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA; 4Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Introduction: We developed the strength training intervention (STRIVE), a home-based exercise program targeting physical function in patients with cirrhosis. In this pilot study, we aimed to evaluate the safety and efficacy of STRIVE.

Methods: Eligible were adult patients with cirrhosis at 3 sites. Read More

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Knowledge of patient emotional health status: impact on clinical care in glaucoma and retinal services.

BMJ Open Ophthalmol 2021 21;6(1):e000640. Epub 2021 Apr 21.

Dana Center for Preventive Ophthalmology, Johns Hopkins Wilmer Eye Institute, Baltimore, Maryland, USA.

Objective: Knowledge of a patient's emotional health status and using patient-centred communication may be key to providing early intervention and referral to appropriate treatment/support services for ophthalmology patients. This study aims to determine if and how ophthalmologists use anxiety and depression scores to determine clinical care of patients with chronic eye disease.

Methods And Analysis: This cross-sectional study included 10 ophthalmologists and a convenience sample of 100 of their patients (>18 years). Read More

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Estimation of minimal clinically important difference for quadriceps and inspiratory muscle strength in older outpatients with chronic obstructive pulmonary disease: a prospective cohort study.

Phys Ther Res 2021 12;24(1):35-42. Epub 2020 Oct 12.

Department of Physical Therapy, Akita University Graduate School of Health Sciences, Japan.

Objective: To estimate the minimal clinically important difference (MCID) of quadriceps and inspiratory muscle strength after a home-based pulmonary rehabilitation program (PRP) in chronic obstructive pulmonary disease (COPD).

Method: Eighty-five COPD patients were included. Quadriceps maximal voluntary contraction (QMVC) was measured. Read More

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October 2020

Feasibility of active surveillance in small testicular mass: a mini review.

Cent European J Urol 2021 4;74(1):10-13. Epub 2021 Feb 4.

Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.

Introduction: Widespread use of scrotal ultrasonography has led to the detection of incidental, non-palpable small testicular masses (STMs). Historically, all intratesticular masses were treated radically, however more conservative strategies are now being applied with growing evidence that up to 80% of STMs are benign lesions. Testis-sparing surgery is deemed a gold standard in STMs. Read More

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February 2021

Cost and social distancing dynamics in a mathematical model of COVID-19 with application to Ontario, Canada.

R Soc Open Sci 2021 Feb 24;8(2):201770. Epub 2021 Feb 24.

Department of Mathematics and Statistics, York University, Toronto, Canada.

A mathematical model of COVID-19 is presented where the decision to increase or decrease social distancing is modelled dynamically as a function of the measured active and total cases as well as the perceived cost of isolating. Along with the cost of isolation, we define an overburden healthcare cost and a total cost. We explore these costs by adjusting parameters that could change with policy decisions. Read More

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February 2021

Minimal changes in telomere length after a 12-week dietary intervention with almonds in mid-age to older, overweight, and obese Australians: Results of a randomised clinical trial.

Br J Nutr 2021 May 11:1-38. Epub 2021 May 11.

Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Adelaide 5001, SA, Australia; (S.J.W.); (A.M.H.); (J.D.B.); (A.M.C.).

Diet is a modifiable risk factor for chronic disease and a potential modulator of telomere length (TL). The study aim was to investigate associations between diet quality and TL in Australian adults after a 12-week dietary intervention with an almond-enriched diet. Participants (overweight/obese, 50-80 years) were randomised to an almond-enriched diet (AED, N=62) or iso-caloric nut-free diet (NFD, N=62) for 12 weeks. Read More

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On a Trajectory for Success: 9 in Every 10 People With a Degenerative Meniscus Tear Have Improved Knee Function in the 2 Years After Treatment-A Secondary Exploratory Analysis of a Randomized Controlled Trial.

J Orthop Sports Phys Ther 2021 May 10:1-29. Epub 2021 May 10.

Division of Orthopedic Surgery, Oslo University Hospital, Oslo, Norway.

Objective: To identify trajectories of patient-reported knee function over five years in patients with degenerative meniscal tears, and to explore whether baseline characteristics were associated with trajectories of sport and recreational function.

Design: Prospective cohort study.

Methods: We conducted a secondary exploratory analysis of the randomized controlled Odense-Oslo Meniscectomy versus Exercise (OMEX) trial. Read More

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Patient, caregiver, and health care provider perspectives on barriers and facilitators to heart failure care in Kerala, India: A qualitative study.

Wellcome Open Res 2020 19;5:250. Epub 2021 Apr 19.

Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, India.

Deficits in quality of care for patients with heart failure (HF) contribute to high mortality in this population. This qualitative study aimed to understand the barriers and facilitators to high-quality HF care in Kerala, India. Semi-structured, in-depth interviews were conducted with a purposive sample of health care providers (n=13), patients and caregivers (n=14). Read More

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Chimeric antigen receptor T cells targeting CD7 in a child with high-risk T-cell acute lymphoblastic leukemia.

Int Immunopharmacol 2021 May 6;96:107731. Epub 2021 May 6.

Department of Hematology and Oncology, Shenzhen Children's Hospital, No. 7019 Yitian Rd, Shenzhen, Guangdong, PR China. Electronic address:

Effective systemic treatments for relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) are limited. Recent clinical application of chimeric antigen receptor (CAR) immunotherapy has demonstrated successful control of B-cell malignancies by CAR-T cells; however, designing CARs for T-ALL remains a challenge. CD7 overexpression in T-cell malignancies may be an attractive target for immunotherapy in T-ALL. Read More

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Minimal change disease relapse following SARS-CoV2 mRNA vaccine.

Kidney Int 2021 May 5. Epub 2021 May 5.

CHU de Nantes, Nantes Université, Néphrologie et Immunologie clinique, Nantes, France; CHU de Nantes, Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France.

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Predictors of clinical outcomes after non-operative management of symptomatic full-thickness rotator cuff tears.

World J Orthop 2021 Apr 18;12(4):223-233. Epub 2021 Apr 18.

Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48106, United States.

Background: Previous studies have shown that non-surgical management can be an effective treatment strategy for many patients with rotator cuff tears. Despite the prevalence of rotator cuff disease, few studies have examined the patient and tear related factors that predict outcomes of nonsurgical management in this cohort of patients.

Aim: To identify factors that are associated with changes in patient reported outcomes over time in individuals with full-thickness rotator cuff tears treated without surgery. Read More

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Trends in post-heart transplant biopsies for graft rejection versus nonrejection.

Proc (Bayl Univ Med Cent) 2021 Jan 26;34(3):345-348. Epub 2021 Jan 26.

Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, Texas.

With alternatives such as gene profiling available for surveillance after orthotopic heart transplantation, we sought to evaluate the utilization of endomyocardial biopsies (EMBs) for hospitalized patients after heart transplantation. Surveillance EMBs in patients with and without complications were evaluated from the 2004 to 2014 National Inpatient Sample. Over the study period, there was no significant change in the number of EMB procedures performed ( = 0. Read More

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January 2021

Collapsing focal segmental glomerulosclerosis in a patient with oral cavity cancer: A case report.

Medicine (Baltimore) 2021 May;100(18):e25857

Department of Internal Medicine, Research Institute of Clinical Medicine, Jeonbuk National University Medical School.

Rationale: Focal segmental glomerulosclerosis (FSGS) is one of the most common glomerular diseases, leading to end-stage renal disease. Among the 5 variants of FSGS, the collapsing variant is rare and has the worst prognosis. Solid and hematologic malignancies are associated with glomerular diseases, such as membranous nephropathy, minimal change disease, and FSGS. Read More

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Association between diuretic administration before diagnosis and incidence of acute kidney injury in patients with minimal change disease: A single-center observational study.

Medicine (Baltimore) 2021 May;100(18):e25845

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Abstract: We examined the association between diuretic administration before the diagnosis of minimal change disease and the incidence of acute kidney injury. Moreover, we examined whether the use of diuretics affected the time to complete remission in adults with such disease.The present study was a single-center, retrospective, observational cohort study. Read More

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Validity of the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) for Japanese patients with labral tear.

J Hip Preserv Surg 2020 Aug 29;7(3):466-473. Epub 2020 Oct 29.

Department of Anesthesiology, Aichi Children's Health and Medical Center, Cincinnati, Ohbu City, Aichi 474-8710, Japan.

The Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) was created for patient-reported outcome measures (PROMs) and to evaluate the conditions of patients with hip disease. Nevertheless, the validity of the JHEQ for patients with hip labral tears remains unclear. Therefore, we validated the JHEQ in patients with labral tears. Read More

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Establishing Thresholds for Minimal Clinically Important Differences for the Peripheral Artery Disease Questionnaire.

Circ Cardiovasc Qual Outcomes 2021 May 5:CIRCOUTCOMES120007232. Epub 2021 May 5.

Vascular Medicine Outcomes (VAMOS) Program, Section of Cardiovascular Medicine, Yale University, New Haven, CT (C.M.-H., Q.-U.-A.J., K.G.S.).

Background: Understanding minimum clinically important differences (MCID) in patient-reported outcomes is essential in interpreting the magnitude of changes in these measures. No MCID from patients' perspectives has ever been published for peripheral artery disease-specific health status assessment tools. The Peripheral Artery Questionnaire (PAQ) is a commonly used, validated peripheral artery disease-specific health status instrument for which we sought to prospectively establish its MCID from patients' perspectives. Read More

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Comprehensive metabolomic profiling in early IgA nephropathy patients reveals urine glycine as a prognostic biomarker.

J Cell Mol Med 2021 May 3. Epub 2021 May 3.

Kidney Research Institute, Seoul National University, Seoul, Korea.

Identification of a urinary metabolite biomarker with diagnostic or prognostic significance for early immunoglobulin A nephropathy (IgAN) is needed. We performed nuclear magnetic resonance-based metabolomic profiling and identified 26 metabolites in urine samples. We collected urine samples from 201, 77, 47, 36 and 136 patients with IgAN, patients with membranous nephropathy, patients with minimal change disease, patients with lupus nephritis and healthy controls, respectively. Read More

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Changes in left ventricular and atrial mechanics and function after dialysis in patients with end-stage renal disease.

Quant Imaging Med Surg 2021 May;11(5):1899-1908

Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Hemodialysis (HD) can influence end-stage renal disease (ESRD) patients' circulatory system. The present study aimed to evaluate the effect of volume depletion on left ventricular (LV) and left atrial (LA) function and determine the volume-independent parameters before and after HD in patients with ESRD.

Methods: Between January 2018 and January 2019, we recruited long-term HD patients (n=40, 51. Read More

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Rifampicin-Associated Secondary Minimal Change Disease Presenting with Nephrotic Syndrome in a Pulmonary Tuberculosis Patient.

Case Rep Nephrol 2021 14;2021:5546942. Epub 2021 Apr 14.

Department of Medicine, S.M.M.H. Government Medical College, Saharanpur, Uttar Pradesh, India.

Various extraglomerular disease processes have been associated with drug-induced secondary minimal change disease (MCD). In a majority of cases, preferably, a hypersensitivity reaction appears to be involved, and in some cases, there is direct toxic effect over glomerular capillaries. There are several reports to demonstrate that rifampicin has been associated with various nephrotoxic adverse effects, but rifampicin-induced secondary minimal change disease (MCD) is very rare. Read More

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Pooled Safety Results Through One Year of Two Phase-3 Trials of Guselkumab in Patients with Psoriatic Arthritis.

J Rheumatol 2021 May 1. Epub 2021 May 1.

Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare's Mercy Hospital, St. John's Newfoundland, Canada A1C 5B8.

Objective: Evaluate safety of guselkumab (monoclonal antibody targeting IL-23p19) in psoriatic arthritis (PsA) patients through 1year (1Y) of the Phase-3 DISCOVER-1&2 trials.

Methods: Patients with active PsA (N=1120; biologic-naïve except the118 TNFi-treated DISCOVER-1 patients) were randomized to subcutaneous guselkumab 100 mg every 4 weeks (Q4W) or at Week 0, Week4, then Q8W; or placebo. At Week24, placebo patients switched to guselkumab 100 mg Q4W. Read More

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RNA-extraction-free nano-amplified colorimetric test for point-of-care clinical diagnosis of COVID-19.

Nat Protoc 2021 Apr 30. Epub 2021 Apr 30.

Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

The global pandemic of coronavirus disease 2019 (COVID-19) highlights the shortcomings of the current testing paradigm for viral disease diagnostics. Here, we report a stepwise protocol for an RNA-extraction-free nano-amplified colorimetric test for rapid and naked-eye molecular diagnosis of COVID-19. The test employs a unique dual-prong approach that integrates nucleic acid (NA) amplification and plasmonic sensing for point-of-care detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with a sample-to-assay response time of <1 h. Read More

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Electrochemical DNA Biosensor That Detects Early Celiac Disease Autoantibodies.

Sensors (Basel) 2021 Apr 10;21(8). Epub 2021 Apr 10.

Department of Chemistry & Biochemistry, Metropolitan State University of Denver, Denver, CO 80204, USA.

Although it is estimated that more than one million Americans have celiac disease (CD), it remains challenging to diagnose. CD, an autoimmune and inflammatory response following the ingestion of gluten-containing foods, has symptoms overlapping with other diseases and requires invasive diagnostics. The gold standard for CD diagnosis involves serologic blood tests followed by invasive confirmatory biopsies. Read More

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Developing a Consistent, Reproducible Botulinum Toxin Type A Dosing Method for Upper Limb Tremor by Kinematic Analysis.

Toxins (Basel) 2021 04 8;13(4). Epub 2021 Apr 8.

Department of Clinical Neurological Sciences, London Health Sciences Centre-Lawson Health Research Institute, 339 Windermere Road, A10-026, London, ON N6A 5A5, Canada.

Botulinum toxin type A (BoNT-A) injection patterns customized to each patient's unique tremor characteristics produce better efficacy and lower adverse effects compared to the fixed-muscle-fixed-dose approach for Essential Tremor (ET) and Parkinson's disease (PD) tremor therapy. This article outlined how a kinematic-based dosing method to standardize and customize BoNT-A injections for tremors was developed. Seven ET and eight PD participants with significant tremor reduction and minimal perceived weakness using optimized BoNT-A injections determined by clinical and kinematic guidance were retrospectively selected to develop the kinematic-based dosing method. Read More

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Performance of the American Heart Association/American College of Cardiology Pooled Cohort Equations to Estimate Atherosclerotic Cardiovascular Disease Risk by Self-reported Physical Activity Levels.

JAMA Cardiol 2021 Apr 28. Epub 2021 Apr 28.

Department of Medicine (Cardiology), Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Importance: The American Heart Association/American College of Cardiology pooled cohort equations (PCEs) are used for predicting 10-year atherosclerotic cardiovascular disease (ASCVD) risk. Pooled cohort equation risk prediction capabilities across self-reported leisure-time physical activity (LTPA) levels and the change in model performance with addition of LTPA to the PCE are unclear.

Objective: To evaluate PCE risk prediction performance across self-reported LTPA levels and the change in model performance by adding LTPA to the existing PCE model. Read More

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[The correlation between polycyclic aromatic hydrocarbons and idiopathic membranous nephropathy].

Zhonghua Yi Xue Za Zhi 2021 Apr;101(16):1149-1153

Department of Nephrology, the First Affiliated Hospital of Zhengzhou University/Research Institute of Nephrology of Zhengzhou University/Research Center for Kidney Disease, Henan Province/Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province/Core Unit of National Clinical Medical Research Center of Kidney Disease, Zhengzhou 450052, China.

To explore the relationship between polycyclic aromatic hydrocarbons (PAHs), the major component of atmospheric pollutant particulate matter 2.5 (PM) and idiopathic membranous nephropathy (IMN) and its possible mechanisms. Thirty-five (24 males and 11 females) patients with IMN confirmed by renal biopsy pathology in the First Affiliated Hospital of Zhengzhou University from June to September 2020 were selected as the research group, with an age of (47. Read More

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Diagnostic and prognostic significance of extent of subepithelial electron dense deposits in membranous glomerulonephritis.

Ultrastruct Pathol 2021 Apr 25:1-12. Epub 2021 Apr 25.

Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK.

There are limited data concerning the range and diagnostic significance of the extent of subepithelial electron dense deposits (SEEDD) in membranous glomerulonephritis (MGN). We described the range, and assessed the diagnostic and prognostic significance of extent of SEEDD, particularly in patients with sparse SEEDD, where diagnostic difficulty can arise. Adult renal biopsies with a confident or suspected histological diagnosis of MGN between 2013 and 2020 were included. Read More

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