7,620 results match your criteria Minimal-Change Disease


Minimum clinically important difference of major patient-reported outcome measures in patients undergoing decompression surgery for lumbar spinal stenosis.

Clin Neurol Neurosurg 2020 May 30;196:105966. Epub 2020 May 30.

Department of Orthopaedic Surgery, Japanese Red Cross Shizuoka Hospital, Shizuoka, Shizuoka, Japan.

Objective: A minimum clinically important difference (MCID) has been increasingly well known in the current era of patient-centered care because it reflects a smallest change that is meaningful for patients following a clinical intervention. Previous studies suggested MCID values are disease and/or procedure dependent. No MCID values have been reported on the lumbar spinal stenosis (LSS) following decompression surgery despite LSS is the most common spinal disease and the main treatment is decompression surgery. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.105966DOI Listing

Perforated Choledochal Cyst: Its Clinical Implications in Pediatric Patient.

Pediatr Gastroenterol Hepatol Nutr 2020 May 8;23(3):259-265. Epub 2020 May 8.

Department of Pediatric Surgery, Pusan National University Children's Hospital, Yangsan, Korea.

Purpose: Perforation of choledochal cyst (CC) is a relatively rare clinical presentation in pediatric populations and difficult to predict preoperatively. We assess the clinical implications by comparing clinical parameters based on a single-center experience between perforated and nonperforated CC to facilitate the appropriate management for future interventions.

Methods: A total of 92 cases of CC in pediatric patients (aged <18 years) who received surgical management between January 2003 and December 2018 at a Pusan National University Children's Hospital were reviewed. Read More

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http://dx.doi.org/10.5223/pghn.2020.23.3.259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231744PMC

B-cell oligoclonal expansions in renal tissue of patients with immune-mediated glomerular disease.

Clin Immunol 2020 May 29:108488. Epub 2020 May 29.

Joint Rheumatology Program, National and Kapodistrian University of Athens Medical School, Laiko Hospital, Athens, Greece. Electronic address:

B-cell clonal expansion has been sporadically described in the blood and/or renal tissue of patients with glomerulonephritides, albeit with unclear pathogenetic role. Herein, using spectratyping analysis, we observed oligoclonal intrarenal B-cell populations in 59% of glomerulonephritis patients with podocyte injury (6/7 with focal segmental glomerulosclerosis, 1/3 minimal change disease, 1/3 idiopathic membranous nephropathy, 3/4 IgA nephropathy, 2/5 membranous lupus nephritis), 20% of glomerulonephritis patients without podocyte involvement (4/13 with mesangial or proliferative lupus nephritis, 0/3 idiopathic membranoproliferative glomerulonephritis, 0/4 pauci-immune vasculitis) and 17% of control patients with renal cancer. In multivariate analysis, oligoclonal B-cells were associated with podocyte injury and the grade of glomerulosclerosis (both p = . Read More

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http://dx.doi.org/10.1016/j.clim.2020.108488DOI Listing

Defining Minimally Important Changes for the Patient Activity Scale-II.

Arthritis Care Res (Hoboken) 2020 May 31. Epub 2020 May 31.

University of Nebraska Medical Center, Omaha, Nebraska, United States.

Purpose: We defined the Minimal Clinically Important Improvement (MCII) and Worsening (MCIW) for the Patient Activity Scale (PAS)-II (range 0-10), a recommended patient-reported outcome measuring rheumatoid arthritis disease activity.

Methods: Data from Forward, The National Databank for Rheumatic Diseases from four 6-month data collection periods was utilized. Both anchor-based and distribution-based methods were used to estimate the MCII and MCIW. Read More

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http://dx.doi.org/10.1002/acr.24335DOI Listing

A case of immune complex mediated tubulointerstitial disease and nephrotic syndrome: anti LRP-2 Nephropathy with diffuse podocyte effacement.

J Nephrol 2020 May 29. Epub 2020 May 29.

Division of Nephrology, Department of Medicine, Saint Louis University School of Medicine, Floor 9, Desloge Towers, 3635 Vista Ave., St. Louis, MO, 63110, USA.

Anti-LDL Receptor-Related Protein 2 (Anti-LRP2) nephropathy is a rare form of kidney disease that affects the older patients and is characterized with acute kidney injury (AKI) and progressive renal tubular injury associated with IgG immune complex deposits along the basement membrane of proximal tubules, and circulating autoantibodies to the proximal tubule brush border protein LRP2 (megalin). We present the case of a 79-year-old man who was hospitalized for worsening malaise, abdominal distention and bilateral lower extremity edema, diagnosed with AKI and had nephrotic range proteinuria. Percutaneous kidney biopsy revealed tubulointerstitial nephritis with IgG immune complex deposits along the basement membrane of proximal tubules and brush borders. Read More

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http://dx.doi.org/10.1007/s40620-020-00762-9DOI Listing

Prospective deep phenotyping of choroideremia patients using multimodal structure-function approaches.

Eye (Lond) 2020 May 28. Epub 2020 May 28.

Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Objective: To investigate the retinal changes in choroideremia (CHM) patients to determine correlations between age, structure and function.

Subjects/methods: Twenty-six eyes from 13 male CHM patients were included in this prospective longitudinal study. Participants were divided into <50-year (n = 8) and ≥50-year (n = 5) old groups. Read More

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http://dx.doi.org/10.1038/s41433-020-0974-1DOI Listing

Urinary Incontinence - Incidence, Associations and Effect of Lung Transplant.

J Heart Lung Transplant 2020 Apr 30;39(4S):S492. Epub 2020 Mar 30.

Physiotherapy, Alfred Hospital, Melbourne, Australia.

Purpose: Compared to healthy peers, the prevalence of urinary incontinence (UI) is greater in males and females with respiratory disease, but the trajectory of UI and relationship with respiratory symptoms is unknown following lung transplantation (LTx).

Aim: Prospective questionnaire study aimed to investigate the prevalence and association with coughing of urinary incontinence before and after LTx.

Methods: The Leicester Cough Questionnaire (LCQ) and International Consultation on Incontinence Questionnaires Modules (ICIQ) were completed by consenting adult LTx candidates and repeated 3 months after their LTx. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.070DOI Listing

Responsiveness and minimal clinically important difference of the Mini-BESTest in patients with Parkinson's disease.

Gait Posture 2020 May 17;80:14-19. Epub 2020 May 17.

ICS Maugeri SPA SB, IRCCS, Institute of Pavia, Italy. Electronic address:

Background: Balance problems in Parkinson's Disease (PD) require appropriate evaluation. While the Mini-BESTest is commonly used to assess dynamic balance, some of its psychometric properties have not yet been addressed.

Research Question: What is the responsiveness and the Minimal Clinically Important Difference (MCID) of the Mini-BESTest in patients with PD?

Methods: One-hundred forty-eight patients with PD underwent a treatment specific for balance skills (1-h session, three times/week for four weeks). Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.05.004DOI Listing

Characterizing the potential for recall bias in anchor-based MCID calculation of patient-reported outcome measures for chronic rhinosinusitis.

Clin Otolaryngol 2020 May 25. Epub 2020 May 25.

Department of Otolaryngology - Head & Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Objective: Anchor-based methods to calculate the minimal clinically important difference (MCID) of a patient-reported outcome measure (PROM) may suffer from recall bias. This has never been investigated for otolaryngic PROMs. We sought to identify evidence of recall bias in calculation of MCIDs of PROMs for patients with chronic rhinosinusitis (CRS). Read More

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http://dx.doi.org/10.1111/coa.13589DOI Listing

Acute myocardial infarction due to fixed coronary artery stenosis from myocardial bridging.

Cardiovasc Revasc Med 2020 Apr 21. Epub 2020 Apr 21.

Department of Cardiovascular Diseases, Mayo Clinic, United States of America; Department of Laboratory Medicine and Pathology, Mayo Clinic, United States of America. Electronic address:

Myocardial bridging is a common coronary abnormality often associated with left ventricular hypertrophy. It can be noted incidentally on coronary angiography by findings of systolic narrowing of the involved coronary artery. We present the case of a 59-year-old woman that presented with a non-ST elevation myocardial infarction. Read More

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http://dx.doi.org/10.1016/j.carrev.2020.04.020DOI Listing

Malaria, Collapsing Glomerulopathy, and Focal and Segmental Glomerulosclerosis.

Clin J Am Soc Nephrol 2020 May 22. Epub 2020 May 22.

Assistance Publique des Hôpitaux de Paris, Hôpitaux Universitaires Henri Mondor, Service de Néphrologie et Transplantation, Centre de Référence Maladie Rare Syndrome Néphrotique Idiopathique, Créteil, France

Background And Objectives: Malaria, a potentially life-threatening disease, is the most prevalent endemic infectious disease worldwide. In the modern era, the spectrum of glomerular involvement observed in patients after malarial infections remains poorly described.

Design, Setting, Participants, & Measurements: We therefore performed a retrospective multicenter study to assess the clinical, biologic, pathologic, and therapeutic characteristics of patients with glomerular disease demonstrated by kidney biopsy in France within 3 months of an acute malaria episode. Read More

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http://dx.doi.org/10.2215/CJN.00590120DOI Listing

Minimal important change for the visual analogue scale foot and ankle (VAS-FA).

Foot Ankle Surg 2020 Apr 27. Epub 2020 Apr 27.

Department of Surgery, Central Finland Hospital District, Jyväskylä, Finland.

Background: Visual analogue scale foot and ankle (VAS-FA) is a patient-reported outcome measure for foot and ankle disorders. The VAS-FA is validated into several languages and well adopted into use. Nonetheless, minimal important change (MIC) for the VAS-FA has not been estimated thus far. Read More

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http://dx.doi.org/10.1016/j.fas.2020.04.005DOI Listing

A randomized controlled clinical trial comparing the use of displacement cords and aluminum chloride paste.

J Esthet Restor Dent 2020 Jun 22;32(4):410-415. Epub 2020 May 22.

Pro Vice Chancellor Health Sciences, University of Otago, Dunedin, New Zealand.

Objectives: This clinical study measured the change in opening and height of the displaced gingiva using paste and cord retraction materials for definitive impression making of natural teeth and assessed if they were comparable and clinically acceptable.

Methods: Impressions of 4 maxilla premolars from 10 participants were taken using a split-mouth protocol. All participants were free of periodontal disease, had a thick biotype, a minimal of 3 mm height of keratinized gingival tissue and gingival sulci depths of 2 mm. Read More

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http://dx.doi.org/10.1111/jerd.12581DOI Listing

Glomerulonephritis Histopathological Pattern Change.

BMC Nephrol 2020 May 18;21(1):186. Epub 2020 May 18.

Mubarak Al-Kabeer Hospital, Department of Internal Medicine, Nephrology Unit, Jabriya, Kuwait.

Background: Glomerulonephritides (GN) are relatively rare kidney diseases with substantial morbidity and mortality. They are often difficult to treat, sometimes with no cure, and can lead to chronic kidney disease (CKD) and end stage kidney disease (ESKD). Kidney biopsy is the diagnostic procedure of choice with variable indications from center to center. Read More

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http://dx.doi.org/10.1186/s12882-020-01836-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236312PMC

New evidence for construct validity and interpretability of the German Quality of Life in Hand Eczema Questionnaire (QOLHEQ).

Contact Dermatitis 2020 May 18. Epub 2020 May 18.

Institute of Social Medicine and Health Systems Research, Otto von Guericke University Magdeburg, Magdeburg, Germany.

Background: The Quality of Life in Hand Eczema Questionnaire (QOLHEQ) is a disease-specific instrument to assess health-related Quality of Life (HRQoL) in hand eczema patients according to the domains of (a) symptoms, (b) emotions, (c) functioning and (d) treatment/prevention. Today it is not clear what a single score of the QOLHEQ in its German language version means to a patient.

Objectives: It was the aim of this study to band the QOLHEQ-score to an anchor question (AQ) in order receive meaningful categories of the QOLHEQ to aid its interpretation. Read More

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http://dx.doi.org/10.1111/cod.13603DOI Listing

Effect of Alemtuzumab Infusions on Vital Signs: A Prospective Observational Study in Patients with Relapsing-Remitting Multiple Sclerosis.

Int J MS Care 2020 Mar-Apr;22(2):53-59

Background: Alemtuzumab efficacy and safety were established in phase 3 randomized trials. We characterize vital signs during and after the first alemtuzumab infusion course.

Methods: Patients with relapsing-remitting multiple sclerosis commercially prescribed alemtuzumab 12 mg/day on 5 consecutive days (initial course) were enrolled in this prospective, observational study. Read More

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http://dx.doi.org/10.7224/1537-2073.2018-076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204363PMC

Liver sinusoidal endothelial cells promote the differentiation and survival of mouse vascularised hepatobiliary organoids.

Biomaterials 2020 Aug 5;251:120091. Epub 2020 May 5.

O'Brien Institute, Department of St Vincent's Institute, Victoria, Australia; University of Melbourne Department of Surgery, St Vincent's Hospital Melbourne, Victoria, Australia; Australian Catholic University, Victoria, Australia.

The structural and physiological complexity of currently available liver organoids is limited, thereby reducing their relevance for drug studies, disease modelling, and regenerative therapy. In this study we combined mouse liver progenitor cells (LPCs) with mouse liver sinusoidal endothelial cells (LSECs) to generate hepatobiliary organoids with liver-specific vasculature. Organoids consisting of 5x10 cells were created from either LPCs, or a 1:1 combination of LPC/LSECs. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120091DOI Listing

Glomerular endothelial cells and podocytes can express CD80 in patients with minimal change disease during relapse.

Pediatr Nephrol 2020 May 12. Epub 2020 May 12.

Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, USA.

Background: Urinary CD80 has emerged as potential biomarker in idiopathic nephrotic syndrome (INS). However, its cellular source remains controversial. The aim of the study was to assess whether CD80 is truly expressed by glomerular cells in INS patients during relapse and in the LPS mouse model of podocyte injury. Read More

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http://dx.doi.org/10.1007/s00467-020-04541-3DOI Listing

Acute Kidney Injury Associated with Minimal Change Nephrotic Syndrome in an Elderly Patient Successfully Treated with both Fluid Management and Specific Therapy Based on Kidney Biopsy Findings.

Case Rep Nephrol Dial 2020 Jan-Apr;10(1):42-50. Epub 2020 Apr 22.

Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Oliguric acute kidney injury (AKI) with minimal change nephrotic syndrome (MCNS) has long been recognized. Several mechanisms such as hypovolemia due to hypoalbuminemia and the nephrosarca hypothesis have been proposed. However, the precise mechanism by which MCNS causes AKI has not been fully elucidated. Read More

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http://dx.doi.org/10.1159/000507426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204776PMC

The ankle brachial index in people with and without diabetes: intra-tester reliability.

J Foot Ankle Res 2020 May 12;13(1):21. Epub 2020 May 12.

School of Health Sciences, University of Newcastle, Ourimbah, Australia.

Background: The ankle-brachial index (ABI) is widely used for determining the presence and severity of peripheral arterial disease (PAD), and current guidelines suggest it should be used to monitor possible progression in affected individuals. It is therefore important that the technique demonstrates adequate reliability for repeated measurements. Existing studies suggest that the ABI is reliable in the general population however, there is a lack of evidence for the reliability of the ABI in people with diabetes. Read More

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http://dx.doi.org/10.1186/s13047-020-00389-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216386PMC

How is the minimal clinically important difference established in health-related quality of life instruments? Review of anchors and methods.

Health Qual Life Outcomes 2020 May 12;18(1):136. Epub 2020 May 12.

Laboratoire de Santé Publique, Faculté de Médecine, Université Aix-Marseille, 3279, Marseille, EA, France.

Background: The aim of this systematic review is to describe the different types of anchors and statistical methods used in estimating the Minimal Clinically Important Difference (MCID) for Health-Related Quality of Life (HRQoL) instruments.

Methods: PubMed and Google scholar were searched for English and French language studies published from 2010 to 2018 using selected keywords. We included original articles (reviews, meta-analysis, commentaries and research letters were not considered) that described anchors and statistical methods used to estimate the MCID in HRQoL instruments. Read More

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http://dx.doi.org/10.1186/s12955-020-01344-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218583PMC

Antibacterial Activity of Strains Isolated from Mongolian Yogurt against .

Biomed Res Int 2020 22;2020:3548618. Epub 2020 Apr 22.

College of Pharmacy, Shanghai Jiaotong University, Shanghai 201100, China.

Worldwide interest in the use of functional foods containing probiotic bacteria such as and for health promotion and disease prevention has increased significantly. Probiotics have demonstrated beneficial properties including strengthening the body's natural defense system, inhibiting the growth of pathogenic bacteria, and regulating mental activity, but their effects on the human vagina have not been fully elucidated. The primary purpose of our study was to isolate strains from old yogurt, a traditional dairy product, and investigate their probiotic potential with respect to the human vaginal system. Read More

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http://dx.doi.org/10.1155/2020/3548618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195648PMC

Clinical utility of serial analysis of circulating tumour cells for detection of minimal residual disease of metastatic nasopharyngeal carcinoma.

Br J Cancer 2020 May 6. Epub 2020 May 6.

Department of Clinical Oncology, University of Hong Kong, Hong Kong (Special Administrative Region), People's Republic of China.

Background: Nasopharyngeal carcinoma (NPC) is an important cancer in Hong Kong. We aim to utilise liquid biopsies for serial monitoring of disseminated NPC in patients to compare with PET-CT imaging in detection of minimal residual disease.

Method: Prospective serial monitoring of liquid biopsies was performed for 21 metastatic patients. Read More

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http://dx.doi.org/10.1038/s41416-020-0871-1DOI Listing

Meaningful improvement thresholds in measures of pain and quality of life in oral lichen planus.

Oral Dis 2020 May 4. Epub 2020 May 4.

UCL Eastman Dental Institute, London, UK.

Objectives: To evaluate the responsiveness of measures of pain and oral health-related quality of life (OH-QoL) in patients with oral lichen planus (OLP) and to determine thresholds for minimal important change (MIC) and minimal important difference (MID) for use in this patient population.

Methods: Data from baseline and 4-month follow-up including Visual Analog Scale (VAS), Numerical Rating Scale (NRS), 14-item Oral Health Impact Profile (OHIP-14), 15-item and 26-item Chronic Oral Mucosal Disease Questionnaire (COMDQ-15; COMDQ-26) were collected from 157 patients with OLP. Responsiveness was assessed by testing hypotheses and calculating the area under the curve. Read More

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http://dx.doi.org/10.1111/odi.13379DOI Listing

The Spectrum of Glomerular Diseases in Mashhad According to Kidney Biopsy Records.

Iran J Kidney Dis 2020 May;14(3):184-190

Kidney Transplantation Complications Research center,Mashhad University of Medical Sciences,Mashhad,Ira.

Introduction: Knowing the national statistics of glomerular diseases will help in the management and minimizing their burden in the community. The aim of this study was to assess the overall distribution of subtypes of glomerulonephritis (GN) and the prevalence of renal diseases in a subgroup of diabetic and hypertensive patients.

Methods: This cross-sectional study was conducted on 860 patients with different subtypes of GN diagnosed by percutaneous renal biopsy and histological examination. Read More

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Methodology and baseline characteristics of a randomized controlled trial testing a health care professional and peer-support program for patients with chronic obstructive pulmonary disease: The BREATHE2 study.

Contemp Clin Trials 2020 Apr 29;94:106023. Epub 2020 Apr 29.

Pulmonary and Critical Care Medicine, The Johns Hopkins School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA.

Background: Self-management support (SMS) for patients with COPD can improve health-related quality of life (HRQOL). However, it remains unclear what SMS strategies are most effective. Using peer support to advance self-management is promising, as peer supporters possess credibility and can serve as role models. Read More

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http://dx.doi.org/10.1016/j.cct.2020.106023DOI Listing

Ecology of Neglected Rodent-Borne American Orthohantaviruses.

Pathogens 2020 Apr 26;9(5). Epub 2020 Apr 26.

Department of Biological Sciences, University of Arkansas, Fayetteville, AR 72701, USA.

The number of documented American orthohantaviruses has increased significantly over recent decades, but most fundamental research has remained focused on just two of them: Andes virus (ANDV) and Sin Nombre virus (SNV). The majority of American orthohantaviruses are known to cause disease in humans, and most of these pathogenic strains were not described prior to human cases, indicating the importance of understanding all members of the virus clade. In this review, we summarize information on the ecology of under-studied rodent-borne American orthohantaviruses to form general conclusions and highlight important gaps in knowledge. Read More

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http://dx.doi.org/10.3390/pathogens9050325DOI Listing

Spray-drying microencapsulation of ascorbic acid: impact of varying loading content on physicochemical properties of microencapsulated powders.

J Sci Food Agric 2020 May 1. Epub 2020 May 1.

Applied Chemistry, School of Applied Sciences, RMIT University, Melbourne, Victoria, Australia.

Background: There is increased interest in the food, pharmaceutical and cosmetic industries in using ascorbic acid as an important component in the human diet for health support and disease prevention. However, its use as an ingredient is limited by its high instability and sensitivity to environmental conditions. Microencapsulation technology has been proposed to increase the stability of ascorbic acid. Read More

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http://dx.doi.org/10.1002/jsfa.10455DOI Listing

Minimal clinically important differences in average, best, worst and current intensity and unpleasantness of chronic breathlessness.

Eur Respir J 2020 Apr 27. Epub 2020 Apr 27.

IMPACCT, Faculty of Health, University of Technology Sydney, Ultimo, New South Wales, Australia.

Background: Chronic breathlessness has devastating consequences. The minimal clinically important difference (MCID) for has been estimated as 9 mm on a 100 mm visual analogue scale (VAS). We aimed to determine MCIDs for commonly used dimensions and recall periods: the and , , and of the last 24 h for chronic breathlessness. Read More

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http://dx.doi.org/10.1183/13993003.02202-2019DOI Listing

Trends and progress of bariatric and metabolic surgery in India.

Updates Surg 2020 Apr 24. Epub 2020 Apr 24.

Institute of Minimal Access, Metabolic and Bariatric Surgery, Max Superspecialty Hospital, Saket, New Delhi, India.

Bariatric and metabolic surgery are being performed in India for 2 decades. Aim of this paper is to evaluate the changing clinical trends over the last 5 years and to present the other aspects helmed by Obesity and Metabolic Surgery Society of India (OSSI) to aid the growth of research, education, data management and registry, quality control, insurance-related issues and policy change. OSSI conducts an annual survey to collect data pertaining to numbers of surgical procedures. Read More

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http://dx.doi.org/10.1007/s13304-020-00774-xDOI Listing

Approach to Diagnosis and Management of Primary Glomerular Diseases Due to Podocytopathies in Adults: Core Curriculum 2020.

Am J Kidney Dis 2020 Jun 21;75(6):955-964. Epub 2020 Apr 21.

Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY. Electronic address:

Podocyte injury is the initiating step in the pathway toward clinically evident forms of nephrotic syndrome known as podocytopathies, represented as either minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS). There are hallmark differences in the histologic appearances of MCD and FSGS, which in turn represent distinct pathogenic models after initial podocyte injury (eg, no change in podocyte number in MCD vs podocyte detachment and death in FSGS). However, MCD and FSGS also share a number of common causes, supporting the theory that these diseases lie along a shared podocytopathy spectrum. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.12.019DOI Listing

139 Early Response with Valbenazine and Long-Term Symptom Reduction in Patients with Tardive Dyskinesia: Post Hoc Analysis of the KINECT 3 Study.

CNS Spectr 2020 Apr;25(2):288-289

Medical Director, Medical Affairs, Neurocrine Biosciences, Inc., San Diego, CA.

Study Objective: Tardive dyskinesia (TD) is a persistent and potentially disabling movement disorder associated with prolonged exposure to antipsychotics and other dopamine receptor blocking agents. Valbenazine is a highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor approved for the treatment of TD in adults. Using data from a long-term study (KINECT 3; NCT02274558), the effects of once-daily valbenazine (40 mg, 80 mg) on TD were assessed using the Abnormal Involuntary Movement Scale (AIMS) in participants who were early responders based on subjective measures, including patient self-report (Patient Global Impression of Change [PGIC]) or clinician judgment (Clinical Impression of Change-Tardive Dyskinesia [CGI-TD]). Read More

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http://dx.doi.org/10.1017/S1092852920000553DOI Listing

Methodological considerations when measuring oral health-related quality of life.

J Oral Rehabil 2020 Apr 23. Epub 2020 Apr 23.

Department of Prosthetic Dentistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Dental patient-reported outcomes (dPROs) and their measures, dPROMs, are fundamental for evidence-based dentistry. However when selecting, applying, and evaluating an instrument with a focus on OHRQoL assessment for adults, several methodological considerations are essential to derive valid and meaningful results.

Methods: In this review article, criteria for selecting the appropriate OHRQoL instrument, aspects of administering the instrument, and how to evaluate resulting scores of single and multiple assessments are presented and critically assessed. Read More

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http://dx.doi.org/10.1111/joor.12983DOI Listing

Use of a Smartphone-Based Mobile App for Weight Management in Obese Minority Stroke Survivors: Pilot Randomized Controlled Trial With Open Blinded End Point.

JMIR Mhealth Uhealth 2020 Apr 22;8(4):e17816. Epub 2020 Apr 22.

Institute for Stroke and Cerebrovascular Disease, University of Texas Health Science Center at Houston, Houston, TX, United States.

Background: Minorities have an increased incidence of early-onset, obesity-related cerebrovascular disease. Unfortunately, effective weight management in this vulnerable population has significant barriers.

Objective: Our objective was to determine the feasibility and preliminary treatment effects of a smartphone-based weight loss intervention versus food journals to monitor dietary patterns in minority stroke patients. Read More

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http://dx.doi.org/10.2196/17816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203620PMC

Responsiveness and minimal clinically important difference of SGRQ-I and K-BILD in idiopathic pulmonary fibrosis.

Respir Res 2020 Apr 21;21(1):91. Epub 2020 Apr 21.

Center for Rare Lung Diseases, Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200, Aarhus N, Denmark.

Background: Idiopathic pulmonary fibrosis (IPF) specific version of St. George's Respiratory Questionnaire (SGRQ-I) and King's Brief Interstitial Lung Disease questionnaire (K-BILD) are validated health-related quality of life (HRQL) instruments, but no or limited data exist on their responsiveness and minimal clinically important difference (MCID). The objectives of this study were to assess responsiveness of SGRQ-I and K-BILD and determine MCID separately for deterioration and improvement in a large, prospective cohort of patients with IPF in a real-world setting. Read More

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http://dx.doi.org/10.1186/s12931-020-01359-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175493PMC

Ustekinumab for the treatment of refractory pediatric Crohn's disease: a single-center experience.

Intest Res 2020 04 22. Epub 2020 Apr 22.

McGill University, Montreal, QC, Canada.

Background/aims: Despite the well-established efficacy of tumor necrosis factor (TNF) antagonists as treatment options for Crohn's disease, many pediatric patients need a change in therapy due to adverse events and loss of response, highlighting the necessity for medications with a different mechanism of action. Ustekinumab has been shown to be effective in inducing clinical remission in some adults with disease refractory to anti-TNF agents, however, minimal data exists in the pediatric population.

Methods: We conducted a retrospective chart review of 11 pediatric patients receiving ustekinumab, specifically extracting baseline data, information on prior treatment and response, indications for starting ustekinumab, clinical information, and laboratory parameters pre- and post-therapy. Read More

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http://dx.doi.org/10.5217/ir.2019.09164DOI Listing

Synaptic withdrawal following nerve injury is influenced by postnatal maturity, muscle-specific properties, and the presence of underlying pathology in mice.

J Anat 2020 Apr 20. Epub 2020 Apr 20.

Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.

Axonal and synaptic degeneration occur following nerve injury and during disease. Traumatic nerve injury results in rapid fragmentation of the distal axon and loss of synaptic terminals, in a process known as Wallerian degeneration (WD). Identifying and understanding factors that influence the rate of WD is of significant biological and clinical importance, as it will facilitate understanding of the mechanisms of neurodegeneration and identification of novel therapeutic targets. Read More

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http://dx.doi.org/10.1111/joa.13187DOI Listing

Morphological Features of Minimal Change Disease and Focal Segmental Glomerulosclerosis Using Repeat Biopsy and Parietal Epithelial Cell Marker.

Kidney Dis (Basel) 2020 Mar 31;6(2):119-124. Epub 2020 Jan 31.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.

Introduction: Minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS) are representative podocyte diseases. The clinical cause of MCD and FSGS has not been clearly elucidated yet. However, it is important to distinguish MCD and FSGS because their prognoses and responses to treatment are quite different. Read More

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http://dx.doi.org/10.1159/000505125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154281PMC

CKD Awareness Among US Adults by Future Risk of Kidney Failure.

Am J Kidney Dis 2020 Apr 15. Epub 2020 Apr 15.

Departments of Medicine, University of California San Francisco, San Francisco, CA; Department of Medicine, Priscilla Chan and Mark Zuckerberg San Francisco General Hospital, San Francisco, CA.

Rationale & Objective: Persons with chronic kidney disease (CKD) are often unaware of their disease status. Efforts to improve CKD awareness may be most effective if focused on persons at highest risk for progression to kidney failure.

Study Design: Serial cross-sectional surveys. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.01.007DOI Listing

Ocular exposure to infectious laryngotracheitis virus alters leukocyte subsets in the head-associated lymphoid tissues and trachea of 6-week-old White Leghorn chickens.

Avian Pathol 2020 May 19:1-14. Epub 2020 May 19.

Department of Veterinary Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.

Infectious laryngotracheitis virus (ILTV), an alphaherpesvirus, causes acute respiratory disease primarily infecting the upper respiratory tract and conjunctiva. Administration of live attenuated ILTV vaccines via eye drop, drinking water, or by coarse spray elicits protective mucosal immunity in the head-associated lymphoid tissues (HALT), of which conjunctiva-associated lymphoid tissue (CALT) and the Harderian gland (HG) are important tissue components. The trachea, a non-lymphoid tissue, also receives significant influx of inflammatory cells that dictate the outcome of ILTV infection. Read More

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http://dx.doi.org/10.1080/03079457.2020.1757036DOI Listing

Blinatumomab for Acute Lymphoblastic Leukemia: The First Bispecific T-Cell Engager Antibody to Be Approved by the EMA for Minimal Residual Disease.

Oncologist 2020 Apr 14;25(4):e709-e715. Epub 2019 Nov 14.

European Medicines Agency, Amsterdam, The Netherlands.

On November 15, 2018, the Committee for Medicinal Products for Human Use (CHMP) recommended the extension of indication for blinatumomab to include the treatment of adults with minimal residual disease (MRD) positive B-cell precursor acute lymphoblastic leukemia (ALL). Blinatumomab was authorized to treat relapsed or refractory B-precursor ALL, and the change concerned an extension of use. On March 29, 2018, the U. Read More

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http://dx.doi.org/10.1634/theoncologist.2019-0559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160312PMC

Disease features associated with a low disease impact in patients with psoriatic arthritis: results of a cross-sectional multicenter study.

Arthritis Res Ther 2020 Apr 15;22(1):82. Epub 2020 Apr 15.

Medical Department, Pfizer, Avenida Europa 20B, Parque Empresarial La Moraleja, 28108, Madrid, Spain.

Background: Patient-reported outcomes measures, such as those provided by the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire, have been found to be a reliable indicator of change during treatment, predictive of long-term outcomes, and the impact of psoriatic arthritis (PsA) on patients' lives. The objective of the study was to describe the demographic and clinical characteristics of PsA patients with a low disease impact and to analyze predictive factors for that state.

Methods: Post hoc analysis of a cross-sectional multicenter study that included 223 consecutive patients. Read More

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http://dx.doi.org/10.1186/s13075-020-02168-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161121PMC

THE INFLAMMATORY BOWEL DISEASE-FATIGUE PATIENT SELF-ASSESSMENT SCALE: TRANSLATION, CROSS-CULTURAL ADAPTATION AND PSYCHOMETRIC PROPERTIES OF THE BRAZILIAN VERSION (IBD-F BRAZIL).

Arq Gastroenterol 2020 Jan-Mar;57(1):50-63

Universidade Federal de Juiz de Fora, Programa de Pós-graduação em Ciências da Reabilitação e Desempenho Físico-Funcional, MG, Brasil.

Background: Fatigue is a common symptom in patients with inflammatory bowel diseases (IBD). A translated and culturally adapted, instrument with robust psychometric for measuring fatigue in Brazilian patients with IBD is needed.

Objective: To translate and cross-culturally adapt the inflammatory Bowel Disease Fatigue Scale (IBD-F) into Brazilian-Portuguese and to test its measurement properties in Brazilian patients with IBD. Read More

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http://dx.doi.org/10.1590/S0004-2803.202000000-10DOI Listing

Rituximab therapy for focal segmental glomerulosclerosis and minimal change disease in adults: a systematic review and meta-analysis.

BMC Nephrol 2020 Apr 15;21(1):134. Epub 2020 Apr 15.

Division of Nephrology, Department of Medicine, Penn State University College of Medicine, Hershey, PA, 17033, USA.

Background: Use of rituximab (RTX) for focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) is widely described in children. Clinical evidence in adults is limited. The objective of this study was to determine the treatment outcomes of RTX in adults with FSGS and MCD. Read More

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http://dx.doi.org/10.1186/s12882-020-01797-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160971PMC

Renal histopathology spectrum in children with kidney diseases in Saudi Arabia, 1998-2017.

Saudi Med J 2020 Apr;41(4):369-375

Department of Pediatric, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To identify the trends in the diagnostic frequency of glomerular disease subtypes by renal biopsy in children in Saudi Arabia over the last 20 years.

Methods: In this retrospective observational study, we identified all patients aged less than 18 years for whom native kidney biopsy was performed between 1998 and 2017. The period during which biopsy was performed (1998-2004, 2005-2011, and 2012-2017) and the demographic information and their association with the prevalence of various glomerular disease subtypes were our primary outcomes. Read More

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http://dx.doi.org/10.15537/smj.2020.4.24999DOI Listing

Pattern of biopsy-proven renal disease in Sabah: A retrospective cross-sectional study over 3.5 years.

Med J Malaysia 2020 03;75(2):152-157

Queen Elizabeth Hospital, Department of Nephrology, Sabah, Malaysia.

Objectives: To explore the epidemiological and histopathological patterns of glomerular diseases in Sabah.

Methods: A state-wide cross-sectional study was conducted. There were 336 native renal biopsies in 296 eligible patients from 1st January 2013 to 30th June 2016. Read More

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Urinary Epidermal Growth Factor as a Marker of Disease Progression in Children With Nephrotic Syndrome.

Kidney Int Rep 2020 Apr 5;5(4):414-425. Epub 2019 Dec 5.

Division of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.

Introduction: Childhood-onset nephrotic syndrome has a variable clinical course. Improved predictive markers of long-term outcomes in children with nephrotic syndrome are needed. This study tests the association between baseline urinary epidermal growth factor (uEGF) excretion and longitudinal kidney function in children with nephrotic syndrome. Read More

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http://dx.doi.org/10.1016/j.ekir.2019.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136430PMC

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia.

J Alzheimers Dis 2020 ;75(2):501-519

TauRx Therapeutics Ltd., Aberdeen, UK.

Background: Hydromethylthionine is a potent inhibitor of pathological aggregation of tau and TDP-43 proteins.

Objective: To compare hydromethylthionine treatment effects at two doses and to determine how drug exposure is related to treatment response in bvFTD.

Methods: We undertook a 52-week Phase III study in 220 bvFTD patients randomized to compare hydromethylthionine at 200 mg/day and 8 mg/day (intended as a control). Read More

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http://dx.doi.org/10.3233/JAD-191173DOI Listing
January 2020

Dose-Response Relationship Between Intracoronary Acetylcholine and Minimal Lumen Diameter in Coronary Endothelial Function Testing of Women and Men With Angina and No Obstructive Coronary Artery Disease.

Circ Cardiovasc Interv 2020 Apr 13;13(4):e008587. Epub 2020 Apr 13.

Division of Cardiovascular Medicine, Stanford Cardiovascular Institute (V.S.P., T.N., Y.K., T.K., D.P.L., W.F.F., A.C.Y., J.A.T.), Stanford School of Medicine, CA.

Background: Intracoronary acetylcholine (Ach) provocation testing is the gold standard for assessing coronary endothelial function. However, dosing regimens of Ach are quite varied in the literature, and there are limited data evaluating the optimal dose. We evaluated the dose-response relationship between Ach and minimal lumen diameter (MLD) by sex and studied whether incremental intracoronary Ach doses given during endothelial function testing improve its diagnostic utility. Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.008587DOI Listing

Thermomechanical Ablation-Assisted Photodynamic Therapy for the Treatment of Acne Vulgaris. A Retrospective Chart Review of 30 Patients.

Lasers Surg Med 2020 Apr 9. Epub 2020 Apr 9.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Weizmann St 6, Tel Aviv, 6423906, Israel.

Background And Objectives: Acne vulgaris, a chronic inflammatory disease, affects more than 90% of teenagers. The first-line treatments for acne vulgaris are topical and oral medications, mainly antibiotics and retinoids. However, antibiotic resistance of Propionibacterium acnes, contraindications, partial response, significant adverse effects, or recurrence creates demand for novel treatment options in acne. Read More

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http://dx.doi.org/10.1002/lsm.23246DOI Listing