55 results match your criteria Mini-Reviews in Medicinal Chemistry[Journal]


Premarital hepatitis screening. Attitude towards screening and the risk factors for transmission.

Saudi Med J 2018 Dec;39(12):1179-1185

College of Medicine, Qassim University, Qassim, Kingdom of Saudi Arabia. E-mail.

Objective: To explore all research articles investigating hepatitis premarital screening programs (PSPs) worldwide, considering all different outcomes of such programs, including efficacy, possible limitations to screening, and participants' knowledge and satisfaction regarding the program. Methods: The present systematic review used the databases of PubMed, Ovid Medline, and Google Scholar to search for articles related to both PSPs and the hepatitis viruses. Research articles were identified between October and December 2017, and articles were selected and extracted based on predefined inclusion and exclusion criteria from the year 1957 up to 2017. Read More

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December 2018
2 Reads

Emerging Models of Drug Metabolism, Transporters, and Toxicity.

Drug Metab Dispos 2018 11;46(11):1556-1561

Pfizer Worldwide Research & Development, Clinical Pharmacology, Cambridge, Massachusetts (A.S.-B.) and Pfizer Worldwide Research & Development, Pharmacokinetics, Dynamics, and Metabolism, Groton, Connecticut (R.S.O.).

This commentary summarizes expert mini-reviews and original research articles that have been assembled in a special issue on novel models of drug metabolism and disposition. The special issue consists of research articles or reviews on novel static or micro-flow based models of the intestine, liver, eye, and kidney. This issue reviews static intestinal systems like mucosal scrapings and cryopreserved intestinal enterocytes, as well as novel bioengineered or chemically engineered intestinal models derived from primary human tissue, iPSCs, enteroids, and crypts. Read More

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November 2018

An Overview of Fish-borne Nematodiases among Returned Travelers for Recent 25 Years- Unexpected Diseases Sometimes Far Away from the Origin.

Korean J Parasitol 2018 Jun 30;56(3):215-227. Epub 2018 Jun 30.

Tropical Diseases Research Center, Faculty of Medicine, Khon Kaen University, 123 Mitrapap Highway, Khon Kaen 40002, Thailand.

Along with globalization of traveling and trading, fish-borne nematodiases seems to be increasing in number. However, apart from occasional and sporadic case reports or mini-reviews of particular diseases in particular countries, an overview of fish-borne nematodiasis among travelers have never been performed. In this review, we gathered fishborne nematodiasis among travelers for recent 25 years by an extensive global literature survey using appropriate keywords, e. Read More

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June 2018
2 Reads

Launch of mini-reviews in hot topics.

Br J Pharmacol 2018 Jul;175(13):2537

University of Naples, Naples, Italy.

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July 2018
1 Read

Mini-reviews based on the First Conference of the Institute of Stress Biology & Medicine "Systems Biology-Medicine and Stress".

Hormones (Athens) 2018 Mar;17(1):3-4

Department of Pharmacology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

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March 2018
3 Reads

Marine Environmental Emergencies in the North Pacific Ocean: Lessons Learned from Recent Oil Spills.

Arch Environ Contam Toxicol 2017 Jul 10;73(1):1-4. Epub 2017 Jul 10.

JWS Consulting LLC, Juneau, AK, 99801, USA.

Increasing marine vessel traffic, and oil and gas exploration and development throughout the North Pacific basin brings increasing risks of oil spills. Recognizing the serious challenges presented to response authorities, this Special Issue was organized by the North Pacific Marine Science Organization to provide an introduction to the current state of scientific understanding regarding the environmental effects of oil spills. Because interactions of spilled oils with biota and their habitats are complex, the most serious environmental damages from these spills are not necessarily those of greatest immediate concern by the public. Read More

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July 2017
8 Reads

Wearable sensors: can they benefit patients with chronic kidney disease?

Expert Rev Med Devices 2017 Jul 28;14(7):505-519. Epub 2017 Jun 28.

a imec The Netherlands - Wearable Health Solutions , Eindhoven , The Netherlands.

Introduction: This article ponders upon wearable medical measurement devices in relation to Chronic Kidney Disease (CKD) and its' associated comorbidities - and whether these might benefit CKD-patients. We aimed to map the intersection(s) of nephrology and wearable sensor technology to help technologists understand medical aspects, and clinicians to understand technological possibilities that are available (or soon will become so). Areas covered: A structured literature search on main comorbidities and complications CKD patients suffer from, was used to steer mini-reviews on wearable sensor technologies clustered around 3 themes being: Cardiovascular-related, diabetes-related and physical fitness/frailty. Read More

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July 2017
32 Reads

2017 in-training initiative of the Journal of Assisted Reproduction and Genetics: the JARG Young Investigator Forum.

J Assist Reprod Genet 2017 Jan 21;34(1):3-5. Epub 2016 Dec 21.

Center for Human Reproduction, 21 East 69th Street, New York, NY, 10021, USA.

The Journal of Assisted Reproduction and Genetics introduces the JARG Young Investigator Forum, an in-training initiative aimed to expand opportunities for young investigators. The JARG Young Investigator Forum has three primary goals: first, to increase opportunities for trainees and young investigators to contribute as researchers and writers. Trainees will be invited to publish mini-reviews based on their area of research interest/expertise and will have the opportunity to indicate "in-training" when submitting manuscripts as first author Educational research pertaining to reproductive medicine training will be added to the purview of the journal. Read More

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January 2017
3 Reads

Biotransformation and bioactivation reactions - 2015 literature highlights.

Drug Metab Rev 2016 05;48(2):113-38

d Pfizer Global Research and Development, La Jolla Laboratories , San Diego , CA , USA.

Since 1972, Drug Metabolism Reviews has been recognized as one of the principal resources for researchers in pharmacological, pharmaceutical and toxicological fields to keep abreast of advances in drug metabolism science in academia and the pharmaceutical industry. With a distinguished list of authors and editors, the journal covers topics ranging from relatively mature fields, such as cytochrome P450 enzymes, to a variety of emerging fields. We hope to continue this tradition with the current compendium of mini-reviews that highlight novel biotransformation processes that were published during the past year. Read More

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May 2016
14 Reads

Heparin centenary - an ever-young life-saving drug.

Int J Cardiol 2016 Jun;212 Suppl 1:S1-4

Organic Chemistry Unit, Ronzoni Institute, Milan, Italy.

On the centenary of the discovery of heparin, the International Journal of Cardiology agreed to publish a collection of mini reviews that summarize the historical development of this ever-young life-saving drug. The present articles deal not only with the historical milestones, but also with current and future perspectives regarding the development of heparin in terms of its structure, as well as on-going biochemical, biological and clinical research. Attention is focused on recent applications of heparin derivatives to non-anticoagulant or antithrombotic therapies, providing particular emphasis on their inhibitory activities, including their potential as anti-cancer agents. Read More

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June 2016
3 Reads

Lipids and immunoinflammatory pathways of beta cell destruction.

Diabetologia 2016 Apr 11;59(4):673-8. Epub 2016 Feb 11.

Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA, 23507, USA.

Islet inflammation contributes to beta cell demise in both type 1 and type 2 diabetes. 12-Lipoxygenase (12-LO, gene expressed as ALOX12 in humans and 12-Lo in rodents in this manuscript) produces proinflammatory metabolites such as 12(S)-hydroxyeicosatetraenoic acids through dioxygenation of polyunsaturated fatty acids. 12-LO was first implicated in diabetes when the increase in 12-Lo expression and 12(S)-hydroxyeicosatetraenoic acid was noted in rodent models of diabetes. Read More

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April 2016
2 Reads

Noninvasive effects measurements for air pollution human studies: methods, analysis, and implications.

J Expo Sci Environ Epidemiol 2015 Jul-Aug;25(4):354-80. Epub 2015 Jan 21.

Department of Environmental Medicine, New York University School of Medicine, Nelson Institute of Environmental Medicine, Tuxedo, New York, USA.

Human exposure studies, compared with cell and animal models, are heavily relied upon to study the associations between health effects in humans and air pollutant inhalation. Human studies vary in exposure methodology, with some work conducted in controlled settings, whereas other studies are conducted in ambient environments. Human studies can also vary in the health metrics explored, as there exists a myriad of health effect end points commonly measured. Read More

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Understanding the role of heteroreceptor complexes in the central nervous system.

Curr Protein Pept Sci 2014 ;15(7):647

Department of Neuroscience Karolinska Institutet Stockholm Sweden.

This special issue is based on a mini-symposium in the area of neurosciences with the title "Understanding the role of heteroreceptor complexes in the central nervous system" held at the Nobel Forum, Karolinska Institutet on December 17th, 2012, organized by Kjell Fuxe, Dasiel O. Borroto-Escuela and Luigi F. Agnati. Read More

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June 2015
7 Reads

A quantitative analysis of the mass media coverage of genomics medicine in China: a call for science journalism in the developing world.

OMICS 2014 Apr 10;18(4):222-30. Epub 2014 Feb 10.

1 School of Public Health, Capital Medical University , Beijing, China .

Science journalism is a previously neglected but rapidly growing area of scholarship in postgenomics medicine and socio-technical studies of knowledge-based innovations. Science journalism can help evaluate the quantity and quality of information flux between traditional scientific expert communities and the broader public, for example, in personalized medicine education. Newspapers can play a crucial role in science and health communication, and more importantly, in framing public engagement. Read More

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April 2014
17 Reads

Foreword.

Authors:
Atta -Ur- Rahman

Mini Rev Med Chem 2014 Jan 13. Epub 2014 Jan 13.

Honorary Life Fellow, Kings College, University of Cambridge, Cambridge, UK.

"Mini-Reviews in Medicinal Chemistry" is now commencing its 14th year. It has grown over the years to a reputable international journal known for rapidly publishing exciting new researches in the field. The journal owes its success and popularity to the very hard work of the Co-Editors, Associate Editors, Regional Editors and Editorial Advisory Board Members to whom I am grateful for their kind guidance and enthusiastic support. Read More

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January 2014
1 Read

Male germ cell development in humans.

Horm Res Paediatr 2014 19;81(1):2-12. Epub 2013 Dec 19.

Pediatric Endocrinology Unit, Department of Women's and Children's Health, Karolinska Institutet and University Hospital, Stockholm, Sweden.

Background: Germ cells are unique cells that possess the ability to transmit genetic information between generations. Detailed knowledge about the molecular and cellular mechanisms determining the fate of human male germ cells still remains sparse. This is partially due to ethical issues limiting the access to research material. Read More

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January 2015
1 Read

Overview: cellular plasticity, cancer stem cells and metastasis.

Cancer Lett 2013 Nov 22;341(1):2-8. Epub 2013 Jun 22.

Molecular Cancer Therapeutics Program, University of Mississippi Medical Center Cancer Institute, USA.

Recently, a number of hypotheses have converged into a unified theoretical framework which addresses the most vexing aspects of cancer: metastasis, relapse and therapeutic resistance. The central component of this framework is the new paradigm of cellular differentiation, once viewed as a unidirectional process, but now recognized as a plastic process in which cancer cells can dedifferentiate into more primitive, stem-like phenotypes. This plasticity is controlled by both intrinsic biochemical processes and bi-directional environmental cues involving cancer-associated non-cancerous cells. Read More

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November 2013
3 Reads

PT quantum mechanics.

Philos Trans A Math Phys Eng Sci 2013 Apr 18;371(1989):20120523. Epub 2013 Mar 18.

Department of Physics, Washington University, St. Louis, MO 63130, USA.

PT-symmetric quantum mechanics (PTQM) has become a hot area of research and investigation. Since its beginnings in 1998, there have been over 1000 published papers and more than 15 international conferences entirely devoted to this research topic. Originally, PTQM was studied at a highly mathematical level and the techniques of complex variables, asymptotics, differential equations and perturbation theory were used to understand the subtleties associated with the analytic continuation of eigenvalue problems. Read More

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The ABCs of membrane transporters in health and disease (SLC series): introduction.

Mol Aspects Med 2013 Apr-Jun;34(2-3):95-107

Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.

The field of transport biology has steadily grown over the past decade and is now recognized as playing an important role in manifestation and treatment of disease. The SLC (solute carrier) gene series has grown to now include 52 families and 395 transporter genes in the human genome. A list of these genes can be found at the HUGO Gene Nomenclature Committee (HGNC) website (see www. Read More

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September 2013
4 Reads

Offshoots of the ESF functional genomics programme.

Authors:
Ulf Landegren

N Biotechnol 2013 Mar 4;30(3):296-8. Epub 2013 Jan 4.

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Dag Hammarskjoldsväg 20, SE-75185 Uppsala, Sweden.

After the conclusion of the second five-year period of the European Science Foundation (ESF) programme on functional genomics, it is time to take stock and evaluate its accomplishments. The programme networked leading scientists from a large number of European countries for strategy discussions about the promotion of functional genomics research, and to arrange scientific meetings and exchange programmes. In brief, I believe this programme has punched above its weight, and that it has successfully contributed to the overall organisation of molecular biosciences in Europe. Read More

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Seven things fish know about ammonia and we don't.

Respir Physiol Neurobiol 2012 Dec 10;184(3):231-40. Epub 2012 Aug 10.

Department of Integrative Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.

In this review we pose the following seven questions related to ammonia and fish that represent gaps in our knowledge. 1. How is ammonia excretion linked to sodium uptake in freshwater fish? 2. Read More

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December 2012
1 Read

The SEQanswers wiki: a wiki database of tools for high-throughput sequencing analysis.

Nucleic Acids Res 2012 Jan 15;40(Database issue):D1313-7. Epub 2011 Nov 15.

School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR.

Recent advances in sequencing technology have created unprecedented opportunities for biological research. However, the increasing throughput of these technologies has created many challenges for data management and analysis. As the demand for sophisticated analyses increases, the development time of software and algorithms is outpacing the speed of traditional publication. Read More

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January 2012
67 Reads

Using learning networks to understand complex systems: a case study of biological, geophysical and social research in the Amazon.

Biol Rev Camb Philos Soc 2011 May 17;86(2):457-74. Epub 2010 Sep 17.

Lancaster Environment Centre, Lancaster University, Lancaster, UK.

Developing high-quality scientific research will be most effective if research communities with diverse skills and interests are able to share information and knowledge, are aware of the major challenges across disciplines, and can exploit economies of scale to provide robust answers and better inform policy. We evaluate opportunities and challenges facing the development of a more interactive research environment by developing an interdisciplinary synthesis of research on a single geographic region. We focus on the Amazon as it is of enormous regional and global environmental importance and faces a highly uncertain future. Read More

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May 2011
18 Reads
7 Citations

An integrated approach to the understanding of Chlamydia infections: Introduction to the 2009 update.

Drugs Today (Barc) 2009 Nov;45 Suppl B:3-5

Laboratory of Immunogenetics, Department of Pathology, VU University Medical Center, 1081HV Amsterdam, The Netherlands.

An integrated, multidisciplinary effort is needed to achieve a greater understanding of the immunopathogenesis of urogenital and ocular Chlamydia trachomatis infections to combat this infection successfully, to prevent long-term complications and to develop a vaccine. The contribution of molecular epidemiology and host-pathogen genomics to the understanding of diseases caused by C. trachomatis was explored in depth by the ICTI Consortium, which was first introduced in the Netherlands in December 2004 at the First Annual Amsterdam Chlamydia Meeting (AACM) and was the subject of a special Drugs of Today supplement published in 2006, entitled "An integrated approach to the understanding of Chlamydia infections". Read More

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November 2009

Introduction to surrogates and evidence-based mini-reviews.

Authors:
Mark A Crowther

Hematology Am Soc Hematol Educ Program 2009 :15-6

Division of Hematology and Thromboembolism, McMaster University, St Joseph's Hospital, Hamilton, Ontario, Canada.

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March 2010
1 Read

The Plant-Associated Microbe Gene Ontology (PAMGO) Consortium: community development of new Gene Ontology terms describing biological processes involved in microbe-host interactions.

BMC Microbiol 2009 Feb 19;9 Suppl 1:S1. Epub 2009 Feb 19.

Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

All microbes that form beneficial, neutral, or pathogenic associations with hosts face similar challenges. They must physically adhere to and/or gain entry to host tissues; they must avoid, suppress, or tolerate host defenses; they must acquire nutrients from the host and successfully multiply. Microbes that associate with hosts come from many kingdoms of life and include bacteria, fungi, oomycetes, and nematodes. Read More

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February 2009

How we have learned about the complexity of physiology, pathobiology and pharmacology of bile acids and biliary secretion.

Authors:
Jose J G Marin

World J Gastroenterol 2008 Oct;14(37):5617-9

During the last decades the concept of bile secretion as merely a way to add detergent components to the intestinal mixture to facilitate fat digestion/absorption and to eliminate side products of heme metabolism has evolved considerably. In the series of mini-reviews that the World Journal of Gastroenterology is to publish in its section of "Highlight Topics", we will intend to give a brief but updated overview of our knowledge in this field. This introductory letter is intended to thank all scientists who have contributed to the development of this area of knowledge in gastroenterology. Read More

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October 2008
1 Read

Synopsis of the International Gap Junction Conference in Elsinore, Denmark August 5-9, 2007.

Cell Commun Adhes 2007 Nov-Dec;14(6):251-7

Institute of Genetics, University of Bonn, Bonn, Germany.

This synopsis covers the main results and conclusions from the platform presentations during the International Gap Junction Conference. More detailed information is provided in the mini reviews on controversial scientific issues, short reports of research results and conference abstracts published in this issue of Cell Communication and Adhesion. Read More

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Transport ATPases into the year 2008: a brief overview related to types, structures, functions and roles in health and disease.

Authors:
Peter L Pedersen

J Bioenerg Biomembr 2007 Dec;39(5-6):349-55

Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, MA 21205-2185, USA.

Transport ATPases can be lumped into four distinct types, P, F, V, and ABC, with the first three designated 20 years ago (Pedersen, P.L. and Carafoli, E. Read More

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December 2007
1 Read

Improving the prognosis of patients after radical cystectomy. Part I: the role of lymph node dissection.

BJU Int 2007 Dec;100(6):1221-4

Department of Urology and Paediatric Urology, Saarland University Hospital, Homburg/Saar, Germany.

The first two reviews are from the same unit in Germany and describe the well-known but still much discussed ways of improving the prognosis of patients undergoing cystectomy for bladder cancer. The authors review the roles of lymph node dissection and perioperative chemotherapy, and draw conclusions which will be of help for patients having this form of therapy. In a further review, authors from Egypt debate the requirement for a refluxing or non-refluxing uretero-ileal anastomosis in low-pressure reservoirs, drawing on their extensive experience in this field. Read More

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December 2007
2 Reads

RNA trafficking and local protein synthesis in dendrites: an overview.

J Neurosci 2006 Jul;26(27):7131-4

Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095-1761, USA.

It is now widely accepted that mRNAs localize to dendrites and that translation of these mRNAs is regulated in response to neuronal activity. Recent studies have begun to reveal the underpinnings of these processes and to underscore the importance of local protein synthesis to synaptic remodeling and plasticity. When Steward and Levy (1982) first reported their observation of polyribosomes at the base of spines, the prevailing view was that all proteins were synthesized in the cell body and then transported to distal compartments of neurons. Read More

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July 2006
1 Read

Clinical trials in patients with biochemically relapsed prostate cancer.

BJU Int 2006 May;97(5):905-10

UCSF Comprehensive Cancer Center, University of California/San Francisco, San Francisco, CA 94115, USA.

In this section there is a wide diversity of mini-reviews, covering several areas of interest for readers. Authors from the USA write about clinical trials in patients with biochemically relapsed prostate cancer, again bridging the divide between medical oncologists and urologists who specialise in urological oncological surgery. The second paper is a joint one from Germany and the USA, bringing the reader up to date with advances in the treatment of stress urinary incontinence. Read More

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May 2006
1 Read

Psychological interventions for multiple sclerosis.

Cochrane Database Syst Rev 2006 Jan 25(1):CD004431. Epub 2006 Jan 25.

Poole Hospital NHS Trust, Dorset Research and Development Support Unit, Cornelia House, Longfleet Road, Poole, Dorset, UK, BH15 2JB.

Background: The unpredictable, variable nature of Multiple Sclerosis (MS), and the possibility of increasing disability, means that a diagnosis can have substantial psychological consequences.

Objectives: To assess the effectiveness of psychological interventions for people with MS.

Search Strategy: We searched 19 databases up to December 2004; Cochrane MS Group Specialised Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PsychINFO, CINAHL and 14 others. Read More

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January 2006

Selecting therapy for maintaining sexual function in patients with benign prostatic hyperplasia.

Authors:
Ajay Nehra

BJU Int 2005 Aug;96(3):237-43

Department of Urology, Mayo Clinic, Rochester, MN 55905, USA.

In the first of these mini-reviews the selection of therapy for the maintenance of sexual function in patients with BPH is outlined, along with an explanation of how altered regulation of neurotransmitters, especially noradrenaline, may underlie the syndrome of LUTS and sexual dysfunction. Other mini-reviews outline the current status of robotic surgery to treat renal and adrenal disorders, and its future applications, and the potential use of the nitric oxide/cGMP pathway as a potential target to treat BOO associated with benign prostatic enlargement. Finally, the capacity to be creative in academic departments is extolled as a core property of academicians, and its surfacing described as having the potential to revitalize individuals and departments. Read More

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August 2005
1 Read

Molecular staging of bladder cancer.

BJU Int 2005 Jul;96(1):7-12

Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, 90033, USA.

Attempts are being made in many laboratories to find new biomarkers for and new methods of molecular staging of bladder cancer. At the forefront of this are the authors from Los Angeles who have contributed the first of four mini-reviews in this section. Other mini-reviews examine the role of hand-assisted laparoscopy in urology, a contribution to the sometimes heated argument about whether laparoscopy should be 'pure' or hand-assisted: in addition, two mini-reviews describe the role of photodynamic diagnosis in managing superficial bladder cancer, and the contribution of non-surgical factors to the success of hypospadias repair. Read More

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Oxidative Mechanisms in Neurodegenerative Disorders. Proceedings from a satellite symposium, Guilin, China, 7-11 February 2004.

Authors:

Mol Neurobiol 2005 ;31(1-3):1-300

This special issue of Molecular Neurobiology presents a series of mini-reviews resulting from an ISN satellite symposium entitled Oxidative Mechanisms in Neurodegenerative Disorders Held at the Guilin Park Hotel, Guilin, China on February 7-11, 2004. The timely topics in this symposium were contributed by more than 20 internationally acclaimed scientists and attended by more than 100 participants interested in this subject matter. This satellite symposium was also part of the 6th Biennial Asian-Pacific Society for Neurochemistry (APSN) meeting held in Hong Kong, China. Read More

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January 2006

[Sensory integration: hierarchy and synchronization].

Authors:
V I Kriukov

Zh Vyssh Nerv Deiat Im I P Pavlova 2005 Mar-Apr;55(2):163-9

This is the first in the series of mini-reviews devoted to the basic problems and most important effects of attention in terms of neuronal modeling. We believe that the absence of the unified view on wealth of new date on attention is the main obstacle for further understanding of higher nervous activity. The present work deals with the main ground problem of reconciling two competing architectures designed to integrate the sensory information in the brain. Read More

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Surgical margin status after radical retropubic prostatectomy.

BJU Int 2005 Feb;95(3):281-4

James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Jefferson Building Rm. 157, 600 North Wolfe Street, Baltimore, MD 21287, USA.

This month there are two mini-reviews on aspects of prostate cancer. The first, from the USA, presents the implications of surgical margin status after radical prostatectomy and the potential role of adjuvant radiation therapy. The second, from the USA and Belgium, discusses the use of hormonal therapy for PSA-only recurrence of prostate cancer after previous local therapy. Read More

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February 2005

Chemical derivatization and mass spectral libraries in metabolic profiling by GC/MS and LC/MS/MS.

J Exp Bot 2005 Jan 23;56(410):219-43. Epub 2004 Dec 23.

Bourne Laboratory, Centre for Chemical and Bioanalytical Sciences, Royal Holloway, University of London, Egham, Surrey TW20 0EX, UK.

An overview is presented of gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS), the two major hyphenated techniques employed in metabolic profiling that complement direct 'fingerprinting' methods such as atmospheric pressure ionization (API) quadrupole time-of-flight MS, API Fourier transform MS, and NMR. In GC/MS, the analytes are normally derivatized prior to analysis in order to reduce their polarity and facilitate chromatographic separation. The electron ionization mass spectra obtained are reproducible and suitable for library matching, mass spectral collections being readily available. Read More

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January 2005
1 Read

Ideas about control of skeletal and cardiac muscle blood flow (1876-2003): cycles of revision and new vision.

Authors:
Loring B Rowell

J Appl Physiol (1985) 2004 Jul;97(1):384-92

Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA.

This perspective examines origins of some key ideas central to major issues to be addressed in five subsequent mini-reviews related to Skeletal and Cardiac Muscle Blood Flow. The questions discussed are as follows. 1). Read More

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Diet and prostate cancer.

Authors:
D Mazhar J Waxman

BJU Int 2004 May;93(7):919-22

Cancer Centre, Division of Medicine, Faculty of Medicine, Imperial College London, London, UK.

There are four mini-reviews in this section, all on different areas of urological interest. Diet and prostate cancer continues to offer areas of clinical and laboratory research for investigation. Not every urologist looks after patients with spinal cord injury, but neuropathic bladder problems caused by other conditions are common. Read More

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The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction.

Pflugers Arch 2004 Feb 18;447(5):465-8. Epub 2003 Nov 18.

Membrane Biology Program and Renal Division, Brigham and Women's Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

The Human Genome Organisation (HUGO) Nomenclature Committee Database provides a list of transporter families of the solute carrier (SLC) gene series (see http://www.gene.ucl. Read More

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February 2004
2 Reads

Vitamins/minerals and genomic stability in humans.

Mutat Res 2001 Apr;475(1-2):1-6

Recommended dietary allowances (RDAs) of micronutrients have been traditionally derived as those levels necessary to prevent symptoms of deficiency diseases. There is increasing evidence that higher levels of many such micronutrients may be necessary for various DNA maintenance reactions, and that the current RDAs for some micronutrients may be inadequate to protect against genomic instability. Supplementation of a normal diet, with either vitamins and/or minerals or with isolated plant polyphenols, is becoming increasingly common in most Western populations. Read More

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April 2001
1 Read

[Stress management in the workplace in the era of industrial and economic change].

Authors:
S Nagata

Sangyo Eiseigaku Zasshi 2000 Nov;42(6):215-20

Department of Mental Health, Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu 807-8555, Japan.

The globalization of the economy and the recent economic recession in Japan has accelerated down-sizing or restructuring of corporations and has resulted in the induction of a wage system according to achievement instead of the traditional seniority wage system, break-down of the life-long employment system, excess labor and increased unemployment. These rapid changes in the labor situation have increased job stress. It was reported in the survey conducted by the Ministry of Labor in 1997 that 62. Read More

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November 2000

Integrin signaling.

Authors:
K M Yamada

Matrix Biol 1997 Oct;16(4):137-41

Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, USA.

Integrins provide dynamic links between cells and extracellular matrix molecules. Although integrins were originally viewed as relatively simple adhesion molecules, it soon became clear that intracellular signal transduction initiated by integrins is centrally involved in many cellular processes. In fact, a remarkable number of classical signaling pathways are now known to be activated or modified by the interactions of cells with matrix proteins via integrins. Read More

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October 1997

A compendium of reviews in biochemistry and molecular biology published in the second half of 1993.

Authors:
I G Giles

Int J Biochem 1994 Oct-Nov;26(10-11):1163-201

Department of Biochemistry, University of Southampton, UK.

1. A compendium of reviews and mini-reviews in Biochemistry and Molecular Biology published in the second half of 1993 is presented. In all 1063 titles are listed from 127 different publications. Read More

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