2,129 results match your criteria Mini-Reviews in Medicinal Chemistry[Journal]


Recent advances in apoptosis: The role of hydrazones.

Mini Rev Med Chem 2019 Apr 10. Epub 2019 Apr 10.

Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Haydapaşa, 34668, İstanbul. Turkey.

The process of programmed cell death in higher eukaryotes (apoptosis), is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is considered as a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development and chemical-induced cell death. Apoptosis seems to play an important key role in the progression of several human diseases like Alzheimer's disease, Parkinson's disease and many types of cancer. Read More

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http://dx.doi.org/10.2174/1389557519666190410125910DOI Listing

2,4-Thiazolidinediones as PTP 1B Inhibitors: A Mini Review (2012-2018).

Mini Rev Med Chem 2019 ;19(7):591-598

School of Pharmaceutical Sciences, Guru Ghasidas Central University, Bilaspur- 495 009 (C.G.), India.

2,4-thiazolidinedione (TZD) scaffold is a synthetic versatile scaffold explored by medicinal chemists for the discovery of novel molecules for the target-specific approach to treat or manage number of deadly ailments. PTP 1B is the negative regulator of insulin signaling cascade, and its diminished activity results in abolishment of insulin resistance associated with T2DM. The present review focused on the seven years journey (2012-2018) of TZDs as PTP 1B inhibitors with the insight into the amendments in the structural framework of TZD scaffold in order to optimize/design potential PTP 1B inhibitors. Read More

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http://www.eurekaselect.com/166652/article
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http://dx.doi.org/10.2174/1389557518666181026092029DOI Listing
April 2019
3 Reads

Passive, Active and Ultrasonic Drug Delivery.

Mini Rev Med Chem 2019 Apr 8. Epub 2019 Apr 8.

Department of Chemistry, Biology and Environmental Science, American University of Sharjah, Sharjah. United Arab Emirates.

Cancer has become one of the most deadly non-communicable diseases globally. Several modalities used to treat cancer patients exist today yet many have failed to prove high efficacy and low side effects. The most common example of such modalities is the use chemotherapeutic drugs to destroy cancerous cells and deter their uncontrolled proliferation. Read More

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http://dx.doi.org/10.2174/1389557519666190408155251DOI Listing
April 2019
1 Read

Chemistry, Analysis, Pharmacokinetics and Pharmacodynamics aspects of Lorcaserin, a selective serotonin 5-HT2C receptor agonist: An update.

Mini Rev Med Chem 2019 Apr 8. Epub 2019 Apr 8.

Pharmaceutics, School of Pharmacy and Technology Management, NMIMS, Shirpur. India.

This review refers to the all-inclusive details of Lorcaserin Hydrochloride, on comprehensive information about synthesis, analytical methods, pharmacodynamics, pharmacokinetics, drug interaction, and adverse effect. Lorcaserin Hydrochloride is (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride chemically. Lorcaserin HCl is a novel synthetic, centrally acting selective serotonin C (5-HT2c) receptor, l agonist, which results in increased satiety and decreased food consumption in patients. Read More

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http://dx.doi.org/10.2174/1389557519666190408154443DOI Listing

Exploring signaling pathways and pancreatic cancer treatment approaches using genetic models.

Mini Rev Med Chem 2019 Mar 27. Epub 2019 Mar 27.

Department of Pharmacology and Toxicology, Boonshoft School of Medicine at Wright State University, Dayton OH 45345. United States.

Despite available treatment options, the overall survival rates of pancreatic cancer patients remain dismal. Multiple counter-regulatory pathways have been identified and shown to be involved in interfering with the efficacy of therapeutic agents. In addition, various known genetic alterations in the cellular signaling pathways have been implicated in affecting the growth and progression of pancreatic cancer. Read More

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http://dx.doi.org/10.2174/1389557519666190327163644DOI Listing
March 2019
1 Read
2.903 Impact Factor

Protective Role of Natural Products in Cisplatin-Induced Nephrotoxicity.

Mini Rev Med Chem 2019 Mar 20. Epub 2019 Mar 20.

Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur. Malaysia.

Cisplatin is a widely used antineoplastic agent for the treatment of metastatic tumors, advanced bladder cancer and many other solid tumors. However, at higher doses, toxicities such as nephrotoxicity may appear. Cisplatin leads to DNA damage and subsequently renal cell death. Read More

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http://dx.doi.org/10.2174/1389557519666190320124438DOI Listing
March 2019
4 Reads

Detoxification of Heterocyclic Aromatic Amines by Probiotic to Inhibit Medical Hazards.

Mini Rev Med Chem 2019 Mar 17. Epub 2019 Mar 17.

Research Committee of students, Department of Food Sciences and Technology, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Science, P. O. Box: 193954741, Tehran. Iran.

Cancer is the second leading factor of human death in the world. Long-term consumption of cooked red meat brings about various types of cancers like colorectal cancer due to formation of heterocyclic aromatic amines (HAAs) during the heating process of meat. There are various solutions for the reduction of these toxicants. Read More

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http://dx.doi.org/10.2174/1389557519666190318102201DOI Listing

Malaria Hybrids: A Chronological Evolution.

Mini Rev Med Chem 2019 Mar 14. Epub 2019 Mar 14.

Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi - 110062. India.

Malaria, an upsetting malaise caused by diverse class of Plasmodium species effects about 40% of world population. The distress associated with it has reached colossal scales owing to the development of resistance to most of the clinically available agents. Hence, the search of newer molecules for malaria treatment and cure is an incessant process. Read More

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http://dx.doi.org/10.2174/1389557519666190315100027DOI Listing

Brain-eating amoebae infection: challenges and opportunities in chemotherapy.

Mini Rev Med Chem 2019 Mar 13. Epub 2019 Mar 13.

Department of Biological Sciences, School of Science and Technology, Sunway University, Subang Jaya 47500, Selangor. Malaysia.

Pathogenic free-living amoeba are known to cause devastating infection of the central nervous system and are often referred to as "brain-eating amoebae". The mortality rate of more than 90% and free-living nature of these amoebae is a cause for concern. It is distressing that the mortality rate has remained the same over the past few decades highlighting lack of interest by the pharmaceutical industry. Read More

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http://dx.doi.org/10.2174/1389557519666190313161854DOI Listing
March 2019
1 Read

Analysis of the essential oils of five Artemisia species and evaluation of their cytotoxic and proapoptotic effects.

Mini Rev Med Chem 2019 Mar 11. Epub 2019 Mar 11.

Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad. Iran.

In this study, the essential oil composition and cytotoxic activities of five Artemisia species was determined. The collected plants were water-distilled separately to obtain oils which were subjected to GC and GC/MS in order to identify their compositions. The cancer cells were exposed to different concentrations of samples. Read More

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http://dx.doi.org/10.2174/1389557519666190311155021DOI Listing

Pharmacological aspects and potential use of phloretin: a systemic review.

Mini Rev Med Chem 2019 Mar 11. Epub 2019 Mar 11.

Department of Biotechnology, Thiruvalluvar University, Serkadu, Vellore- 632115. Tamilnadu. India.

Over the past two decades, many researchers have concluded that a diet rich in polyphenolic compounds plays an important therapeutic role in reducing the risk of cancer, cardiovascular disease, inflammation, type II diabetes, and other degenerative diseases. Polyphenolic compounds have been reported to be involved in neutralization of reactive oxygen species and charged radicals, and have anti-carcinogenic effects, hepatoprotective effects, low-glycaemic response, and other benefits. The benefits of fruits and vegetables may be partly attributable to polyphenolic compounds, which have antioxidant and free radical scavenging properties. Read More

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http://dx.doi.org/10.2174/1389557519666190311154425DOI Listing
March 2019
12 Reads
2.903 Impact Factor

Synthesis of Novel Bis-pyrazole Derivatives as Antimicrobial Agents.

Mini Rev Med Chem 2019 Mar 12. Epub 2019 Mar 12.

Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613. Egypt.

Background: bis-heterocycles especially those contain pyrazole moiety displayed much better antibacterial activity than mono heterocycles.

Objective: we interested herein to synthesis a series of new bis-pyrazoles and investigate its antimicrobial agents.

Method: A novel series of bis-pyrazole derivatives has been synthesized in good yield by coupling reaction of cyanoacetic acid {4-[(2-cyano-acetyl)-hydrazonomethyl]-benzylidene}-hydrazide with a number of diazonium salts of aromatic amines in DMF in the presence of NaOH. Read More

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http://dx.doi.org/10.2174/1389557519666190313095545DOI Listing
March 2019
5 Reads

Recent Advances towards Treatment of HIV: Synthesis and SAR Studies.

Mini Rev Med Chem 2019 Mar 12. Epub 2019 Mar 12.

Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451. Saudi Arabia.

In the present study authors wants to encouraged the research exertions through structure activity relationship for the identification of effective molecules for treatment of Human immunodeficiency virus because now a days globally AIDS is considered as one of the main cause of death in human beings. A diversity of biological sources has been searched and developed for the treatment of HIV but unfortunately till now no medicine is found to be fully effective, safe and cure of patients. Human immunodeficiency virus is a lentivirus type which cause the infection of HIV and once remain in human body for longer period of time triggered immunodeficiency syndrome. Read More

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http://dx.doi.org/10.2174/1389557519666190312170158DOI Listing
March 2019
1 Read

Synthesis, Docking Studies into CDK-2 and Anticancer Activity of New Derivatives Based Pyrimidine Scaffold and Their Derived Glycosides.

Mini Rev Med Chem 2019 Mar 12. Epub 2019 Mar 12.

Photochemistry Department, National Research Centre, Dokki, Cairo. Egypt.

New diaryl-substituted pyrimidinedione compounds, their thioxo derivatives as well as their bicyclic thiazole compounds were synthesized and characterized. The glycosylamino derivatives of the synthesized disubstituted derivatives of the pyrimidine scaffold were also prepared via reaction of the N3-amino derivatives with a number of monosaccharides followed by acetylation. The anticancer activity of the synthesized compounds was studied against human liver cancer (HepG2) and RPE-1cell lines. Read More

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http://www.eurekaselect.com/170670/article
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http://dx.doi.org/10.2174/1389557519666190312165717DOI Listing
March 2019
2 Reads

Therapeutic Potential of Vanillin and its Main Metabolites to Regulate the Inflammatory Response and Oxidative Stress.

Mini Rev Med Chem 2019 Mar 12. Epub 2019 Mar 12.

Department of Pharmaceutical Sciences, Universidade Federal da Paraíba, João Pessoa. Brazil.

Many phenolic compounds found in foods and medicinal plants have shown interesting therapeutic potential and have attracted the attention of the pharmaceutical industry as promising pharmacologically active compounds in health promotion and disease prevention. Vanillin is a phenolic aldehyde, widely used as a flavoring agent in the food, pharmaceutical, and cosmetics industries. A variety of pharmacological activities has been attributed to this compound and its main metabolites, vanillic acid and vanillyl alcohol, including their anti-inflammatory ability. Read More

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http://dx.doi.org/10.2174/1389557519666190312164355DOI Listing
March 2019
2 Reads

Follistatin-like 1 in Cardiovascular Disease and Inflammation.

Mini Rev Med Chem 2019 Mar 12. Epub 2019 Mar 12.

Department of Cardiology, Experimental Cardiology Laboratory, UMC Utrecht Regenerative Medicine Centre, University Medical Centre Utrecht, University Utrecht, Utrecht. Netherlands.

Follistatin-like 1 (FSTL1), a secreted glycoprotein, has been shown to participate in regulating developmental processes and to be involved in states of disease and injury. Spatiotemporal regulation and posttranslational modifications contribute to its specific functions and make it an intriguing candidate to study disease mechanisms and potentially develop new therapies. With cardiovascular diseases as the primary cause of death worldwide, clarification of mechanisms underlying cardiac regeneration and revascularization remains essential. Read More

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http://dx.doi.org/10.2174/1389557519666190312161551DOI Listing
March 2019
1 Read

A Review on the Antitumor Activity of Various Nitrogenous-based Heterocyclic Compounds as NSCLC Inhibitors.

Mini Rev Med Chem 2019 Mar 12. Epub 2019 Mar 12.

Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014. China.

At present, cancers have been causing deadly fears to humans and previously incogitable losses to health. Especially, lung cancer is one of the most common causes of cancer-related mortality accounting for approximately 15% of all cancer cases worldwide. While non-small cell lung carcinomas (NSCLCs) makes up to 80% of lung cancer cases. Read More

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http://dx.doi.org/10.2174/1389557519666190312152358DOI Listing

Antidotes against methanol poisoning, a review.

Authors:
Miroslav Pohanka

Mini Rev Med Chem 2019 Mar 12. Epub 2019 Mar 12.

Faculty of Military Health Sciences, University of Defense, Trebesska 1575, Hradec Kralove CZ-50001. Czech Republic.

methanol is the simplest alcohol at all. Comparing to ethanol that is fully detoxified by metabolism, methanol become activated to toxic products by enzymes alcohol dehydrogenase and aldehyde dehydrogenase. Paradoxically, the same enzymes convert ethanol up to harmless acetic acid. Read More

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http://dx.doi.org/10.2174/1389557519666190312150407DOI Listing

Potentials of Diphenyl Ether Scaffold as a Therapeutic Agent: A Review.

Mini Rev Med Chem 2019 Mar 12. Epub 2019 Mar 12.

Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHE, Manipal, Karnataka. India.

Diphenyl ethers (DPE) and its analogs have exhibited an excellent potential for therapeutic and industrial applications. Since the 19th century, intensive research is perpetuating on the synthetic routes and biological properties of DPEs. Few well-known DPEs are Nimesulide, Fenclofenac, Triclosan, Sorafenib, MK-4965, and MK-1439 which have shown the potential of this moiety as a lead scaffold for different pharmacological properties. Read More

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http://www.eurekaselect.com/170657/article
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http://dx.doi.org/10.2174/1389557519666190312150132DOI Listing
March 2019
3 Reads

Exploring the chemistry and therapeutic potential of triazoles: A comprehensive literature review.

Mini Rev Med Chem 2019 Mar 12. Epub 2019 Mar 12.

Department of Pharmaceutical Chemistry, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014. India.

Triazole has occur as a valuable platform in medicinal chemistry, acquiring assorted pharmacological properties, which could play a major role against the common mechanisms associated with various disorders like cancer, infections, inflammation, convulsions, oxidative stress and neurodegeneration etc. Structural modification of this scaffold could be helpful in the generation of new therapeutically useful agents. Although research endeavors are moving towards the growth of synthetic analogs of triazole, there is still lot of scope to achieve drug discovery break-through in this area. Read More

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http://dx.doi.org/10.2174/1389557519666190312162601DOI Listing
March 2019
2.903 Impact Factor

Bioactive Compounds from Seaweed with Anti-Leukemic Activity: A Mini-Review on Carotenoids and Phlorotannins.

Mini Rev Med Chem 2019 Mar 10. Epub 2019 Mar 10.

Team of Histomorphology, Physiopathology and Applied Toxicology, CIIMAR/CIMAR - Interdisciplinary Center for Marine and Environmental Research, U.Porto - University of Porto, Avenida General Norton de Matos s/n, 4450-208 Matosinhos. Portugal.

Chronic myeloid leukemia (CML) represents 15 - 20% of all new cases of leukemia and is characterized by an uncontrolled proliferation of abnormal myeloid cells. Currently, the first-line of treatment involves tyrosine kinase inhibitors (TKIs), which specifically inhibits the activity of the fusion protein BCR-ABL. However, resistance, mainly due to mutations, can occur. Read More

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http://dx.doi.org/10.2174/1389557519666190311095655DOI Listing
March 2019
2 Reads

Coumarin Hybrids: Promising Scaffolds in the Treatment of Breast Cancer.

Mini Rev Med Chem 2019 Mar 8. Epub 2019 Mar 8.

Department of Pharmaceutical Chemistry, Indo-Soviet Friendship College of Pharmacy (ISFCP), Moga-142001. India.

Breast cancer is the most common invasive cancer in women, and the second main cause of cancer death in women, after lung cancer. There is continuous advancement in the development of therapeutic agents against breast cancer in the recent years and still in progress. Development of hybrid molecules by combining different pharmacophores to obtain significant biological activity is an excellent approach. Read More

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http://dx.doi.org/10.2174/1389557519666190308122509DOI Listing

Pathological role of advanced glycation end products (AGEs) and their receptor axis in atrial fibrillation.

Mini Rev Med Chem 2019 Mar 11. Epub 2019 Mar 11.

Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume 830-0011. Japan.

Accumulating evidence has shown that incidence of atrial fibrillation (AF) is higher in patients with diabetes, especially those with poor glycemic control or long disease duration. Non-enzymatic glycation of amino acids of proteins, lipids, and nucleic acids has progressed under normal aging process and/or diabetic condition, which could lead to the formation and accumulation of advanced glycation end products (AGEs). AGEs not only alter the tertiary structure and physiological function of macromolecules, but also evoke inflammatory and fibrotic reactions through the interaction of cell surface receptor for AGEs (RAGE), thereby being involved in aging-related disorders. Read More

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http://dx.doi.org/10.2174/1389557519666190311140737DOI Listing

Clinical Management of Oral Lichen Planus: A Systematic Review.

Mini Rev Med Chem 2019 Mar 1. Epub 2019 Mar 1.

University of Milan-Bicocca. Italy.

Aim: The clinical management of OLP represents a considerable challenge for the oral physician. The aim of this review is to assess the main intervention used in the management of OLP and the efficacy of every type of treatment.

Materials And Methods: We searched and analyzed PubMed database for articles on OLP management. Read More

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http://www.eurekaselect.com/170373/article
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http://dx.doi.org/10.2174/1389557519666190301144157DOI Listing
March 2019
3 Reads
2.903 Impact Factor

Synthesis, structural characterization, molecular modeling and DNA binding ability of CoII, NiII, CuII, ZnII, PdII and CdII complexes of benzocycloheptenone thiosemicarbazone ligand.

Mini Rev Med Chem 2019 Mar 1. Epub 2019 Mar 1.

Chemistry Department, Faculty of Science, Cairo University, Gizza. Egypt.

Six novel complexes of transition metal namely, [CoLCl2(H2O)2]0.5H2O, [NiLCl2(H2O)2]0.5H2O, [CuLCl2]0. Read More

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http://dx.doi.org/10.2174/1389557519666190301143322DOI Listing
March 2019
2 Reads

New strategies for the delivery of some natural anti-oxidants with therapeutic properties.

Mini Rev Med Chem 2019 Feb 28. Epub 2019 Feb 28.

Department of Life Sciences and Biotechnologies, University of Ferrara, I-44121 Ferrara. Italy.

Nature offers a tremendous potential in medicine field. Natural antioxidant molecules inhibit or quench free radical reactions and delay or inhibit cellular damage. In the last few years researchers have been focusing on the health benefits of natural products. Read More

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http://dx.doi.org/10.2174/1389557519666190228160242DOI Listing
February 2019
4 Reads

Human Galectin-1 and its inhibitors: Privileged target for cancer and HIV.

Mini Rev Med Chem 2019 Mar 4. Epub 2019 Mar 4.

Department of Medicinal Chemistry, National Institute of pharmaceutical Education and Research (NIPER) - Hyderabad, Balanagar, 500037. India.

Galectin 1(Gal-1), a β-galactoside binding mammalian lectin of 14KDa, implicate in many signalling pathways, immune responses associated with cancer progression and immune disorders. Inhibition of human Gal-1 has been regarded as one of the potential therapeutic approaches for the treatment of cancer, as it plays a major role in tumour development and metastasis by modulating various biological functions viz. apoptosis, angiogenesis, migration, cell immune escape. Read More

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http://dx.doi.org/10.2174/1389557519666190304120821DOI Listing
March 2019
6 Reads

Correlation between in vitro and in vivo data of radiolabeled peptide for tumor targeting.

Mini Rev Med Chem 2019 Mar 4. Epub 2019 Mar 4.

Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical, Sciences, Sari. Iran.

The targeting peptides have been generally developed by the overexpression of tumor specific receptors in cancer. The use of specific radiolabeled peptide allows tumor visualization by single photon emission computed tomography (SPECT) and positron emission tomography (PET) instruments. Accordingly, this strategy relies on the high affinity and specific binding of radiolabeled peptide respect to tumoral receptors. Read More

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http://dx.doi.org/10.2174/1389557519666190304120011DOI Listing
March 2019
3 Reads
2.903 Impact Factor

Occurrence and Biological Activities of Phenylpropionyl Iridoids.

Mini Rev Med Chem 2019 ;19(4):292-309

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.

As noteworthy members of the terpenoid family, iridoids are a group of natural compounds that have a cyclopentane ring and hemiacetal structural features. Among them, phenylpropionyl iridoids- widely present in Bignoniaceae, Rubiaceae, Scrophulariaceae, Verbenaceae, and Oleaceae- were discovered and extracted from plants mainly between the 1980s and 2000s. Because of their unique structural features and complex stereo configurations, these compounds exhibit numerous desirable biological activities such as neuroprotective, anti-inflammatory, antimicrobial, and antitumour activities; they have received increasing interest recently. Read More

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http://dx.doi.org/10.2174/1389557518666181026091449DOI Listing
March 2019
11 Reads

Some Possibilities to Study New Prophylactics against Nerve Agents.

Mini Rev Med Chem 2019 02 28. Epub 2019 Feb 28.

Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic

Nerve agents belong to the most dangereous chemical warfare agents and can be/were misused by terrorists. Effective prophylaxis and treatment is necessary to diminish their effect. General principles of prophylaxis are summarized (protection against acetylcholinesterase inhibition, detoxification, treatment “in advance” and use of different drugs). Read More

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http://dx.doi.org/10.2174/1389557519666190301112530DOI Listing
February 2019
3 Reads

Scaffold Based Search On The Desferithiocin Archetype.

Mini Rev Med Chem 2019 Mar 1. Epub 2019 Mar 1.

Department of Pharmaceutical Sciences & Technology Birla Institute of Technology, Mesra Ranchi, Jharkhand 835215. India.

Iron overload disorder and diseases where iron mismanagement plays a crucial role requires orally available iron chelators with favourable pharmacokinetic & toxicity profile. Desferrithiocin (DFT), a tridentate and orally available iron chelator has with favourable pharmacokinetic profile but its use has been clinically restricted due to its nephrotoxic potential. The chemical architecture of the DFT has been naturally well optimized for better iron chelation and iron clearance from human biological system. Read More

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http://dx.doi.org/10.2174/1389557519666190301151151DOI Listing
March 2019
5 Reads

Pharmacophores modeling in terms of prediction of theoretical physico-chemical properties and verification by experimental correlations of Carbacylamidophosphates (CAPh) and Sulfanylamidophosphates (SAPh) Tested as New Carbonic Anhydrase Inhibitors.

Mini Rev Med Chem 2019 Feb 22. Epub 2019 Feb 22.

Department of Chemistry, Faculty of Science, Cairo University, Giza. Egypt.

Background: The function of Carbonic anhydrase is to facilitate the physiological process i.e. interconversion of CO2 to HCO3- by hydration. Read More

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http://dx.doi.org/10.2174/1389557519666190222172757DOI Listing
February 2019
4 Reads
2.903 Impact Factor

Synthesis and Molecular Docking of New Thiophene Derivatives as Lactate Dehydrogenase-A Inhibitors.

Mini Rev Med Chem 2019 Feb 12. Epub 2019 Feb 12.

Drug Exploration & Development Chair (DEDC), Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Riyadh 11451. Saudi Arabia.

A series of novel derivatives possessing the thiophene moiety were synthesized using ethyl 5'-amino-2,3'-bithiophene-4'-carboxylate as starting material. The new synthesized derivatives were screened as lactate dehydrogenase (LDH) inhibitors. LDH plays an important role in glucose metabolism in cancer cells and can affect tumor genesis and metastasis. Read More

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http://dx.doi.org/10.2174/1389557519666190212165302DOI Listing
February 2019
2 Reads
2.903 Impact Factor

Molecular Understanding of the Cardiomodulation in Myocardial Infarction and the Mechanism of Vitamin E Protection.

Mini Rev Med Chem 2019 Jan 30. Epub 2019 Jan 30.

Department of Biochemistry, Faculty of Medicine, UKM Medical Centre, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala Lumpur. Malaysia.

Myocardial infarction is a major cause of deaths globally. Modulation of several molecular mechanisms occur during the initial stages of myocardial ischemia prior to permanent cardiac tissue damage, which involve both pathogenic as well as survival pathways in the cardiomyocyte. Currently, there are increasing evidence regarding the cardioprotective role of vitamin E in alleviating the disease. Read More

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http://dx.doi.org/10.2174/1389557519666190130164334DOI Listing
January 2019
1 Read

Ultrasound assisted synthesis of 3-(het)aryl isocoumarin derivatives and their in vitro pharmacological evaluation.

Mini Rev Med Chem 2019 Jan 30. Epub 2019 Jan 30.

Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046. India.

In view of numerous biological activities of 3-substituted isocoumarins a number of analogues based on this scaffold were synthesized for their in vitro pharmacological evaluation. Syntheses of these compounds were carried out via a Pd/C-catalyzed Suzuki-Miyaura coupling of 3-chloroisochromen-1-one with a range of boronic acid derivatives. This C-C bond forming reaction was facilitated by ultrasound irradiation to afford the desired products in good yields. Read More

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http://dx.doi.org/10.2174/1389557519666190130163708DOI Listing
January 2019
3 Reads

Resveratrol and Its Analogues: Recent Advances in Structural Modification and Bioactivity.

Mini Rev Med Chem 2019 Jan 27. Epub 2019 Jan 27.

School of Biological and Medical Engineering, Hefei University of Technology, Hefei, 230009. China.

Resveratrol is a non-flavonoid polyphenol compound containing terpenoid structure. It has been intensively studied because of its wide variety of promising biological properties, such as anticancer, antioxidant, antibacterial, neuroprotection and anti-inflammatory activities. However, the medicinal application of resveratrol is extremely constrained due to its poor bioavailability and stability. Read More

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http://dx.doi.org/10.2174/1389557519666190128093840DOI Listing
January 2019
1 Read
2.903 Impact Factor

Phytochemical profiles and antibacterial activities of Origanum vulgare and Hypericum perforatum and carvacrol and hypericin as a promising anti-Staphylococcus aureus.

Mini Rev Med Chem 2019 Jan 21. Epub 2019 Jan 21.

Razi Herbal Medicines Research Center and Department of Microbiology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad. Iran.

Objectives: Staphylococcus aureus, a Gram-positive bacteria, is ranked second among the causes of hospital infections and is one of the three main causes of food poisoning. In recent times, the spread of antibiotic resistance in S. aureus has become very worrisome. Read More

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http://dx.doi.org/10.2174/1389557519666190121124317DOI Listing
January 2019
1 Read

Research Progress of Glycyrrhizic Acid on Antiviral Activity.

Mini Rev Med Chem 2019 Jan 18. Epub 2019 Jan 18.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, No.163 Xianlin Road, Nanjing 210023. China.

Glycyrrhizic acid (GA), a triterpene isolated from the roots and rhizomes of licorice, named Glycyrrhiza glabra, is the principal bioactive ingredient of anti-viral, anti-inflammatory and hepatoprotective effects. GA has been used in the clinical treatment of hepatitis, bronchitis, gastric ulcer, AIDS (acquired immunodeficiency syndrome), certain cancers and skin diseases. It has a direct effect on anti-HBV (hepatitis B virus) via affecting the HBsAg (hepatitis B surface antigen) to extracellular secretion, improving liver dysfunction in patients with chronic hepatitis B, and ultimately improving the immune status of HBV. Read More

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http://dx.doi.org/10.2174/1389557519666190119111125DOI Listing
January 2019
29 Reads

Chitosan and its derivatives - biomaterials with diverse biological activity for manifold applications.

Mini Rev Med Chem 2019 Jan 12. Epub 2019 Jan 12.

Tricomed SA, ul. Swietojanska 5/9, 93-493 Lodz. Poland.

Derived from chitin, chitosan a natural polycationic linear polysaccharide is the second the most abundant polymer next to cellulose. The main obstacle in the wide use of chitosan is its almost complete lack of solubility in water and alkaline solutions. To break this obstacles the structure of chitosan is subjected to modification, improving its physic-chemical properties and facilitating application as components of composites or hydrogels. Read More

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http://dx.doi.org/10.2174/1389557519666190112142735DOI Listing
January 2019
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Preface.

Authors:
George Perry

Mini Rev Med Chem 2019 ;19(1)

College of Sciences, The University of Texas at San Antonio, Texas, United States.

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http://dx.doi.org/10.2174/138955751901181206141758DOI Listing
January 2019
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Carbocyclic Analogues of Distamycin and Netropsin.

Mini Rev Med Chem 2019 ;19(2):98-113

Department of Organic Chemistry, Medical University, Bialystok 15-222, Mickiewicza Street 2c, Poland.

The DNA as the depository of genetic information is a natural target for chemotherapy. A lot of anticancer and antimicrobial agents derive their biological activity from their selective interaction with DNA in the minor groove and from their ability to interfere with biological processes such as enzyme catalysis, replication and transcription. The discovery of the details of minor groove binding drugs, such as netropsin and distamycin A, oligoamides built of 4-amino-1-methylpyrrole-2-carboxylic acid residues, allowed to develop various DNA sequence-reading molecules, named lexitropsins, capable of interacting with DNA precisely, strongly and with a high specificity, and at the same time exhibiting significant cytotoxic potential. Read More

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http://dx.doi.org/10.2174/1389557518666181009143203DOI Listing
January 2019
5 Reads

Design, Synthesis and Anticancer Activity of New Thiazole-Tetrazole or Triazole Hybrid Glycosides Targeting CDK-2 via Structure-Based Virtual Screening.

Mini Rev Med Chem 2018 Dec 31. Epub 2018 Dec 31.

Photochemistry Department, National Research Centre, El-Behouth St, Dokki, Cairo. Egypt.

The target tetrazole glycosides were synthesized by construction of ring system by cycloaddition reaction of benzothiazole-linked nitrile derivative and sodium azide followed by N-glycosylation process and deprotection. The triazole glycosides were resulted by applying click approach involving dipolar cycloaddition of benzothiazole possessing alkyne functionality and different glycosyl azides. The products incorporating acyclic analogs of sugar moieties were synthesized through alkylation using acyclic oxygenated halides. Read More

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http://www.eurekaselect.com/168652/article
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http://dx.doi.org/10.2174/1389557519666181231121217DOI Listing
December 2018
4 Reads

A Review on Molecular Mechanism of Flavonoids as Antidiabetic Agents.

Mini Rev Med Chem 2018 Dec 27. Epub 2018 Dec 27.

Laboratory of Natural Products, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda (Pb.). India.

The development of drugs possessing anti-diabetic activities is a long pursual goal in drug discovery. It has been shown that deregulated insulin mediated signaling, oxidative stress, obesity, and β-cell dysfunction are the main factors responsible for the disease. With the advent of new and more powerful screening assays and prediction tools, the idea of a drug that can effectively treat diabetes by targeting different pathways has re-bloomed. Read More

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http://dx.doi.org/10.2174/1389557519666181227153428DOI Listing
December 2018
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Hybrid Molecules Development: A Versatile Landscape for the Control of Antifungal Drug Resistance: A Review.

Mini Rev Med Chem 2019 ;19(6):450-464

Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus, Johannesburg, South Africa.

Hybrid molecule approach of drug design has become popular due to advantages such as delayed resistance, reduced toxicity, ease of treatment of co-infection and lower cost of preclinical evaluation. Antifungal drugs currently available for the treatment of fungal diseases suffer a major side effect of drug resistance. Hybrid drugs development is one of the approaches that has been employed to control microbial resistance. Read More

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http://dx.doi.org/10.2174/1389557519666181210162003DOI Listing
March 2019
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Design, Synthesis and Therapeutic Potential of Some 6, 6'-(1,4- phenylene)bis(4-(4-bromophenyl)pyrimidin-2-amine)analogues.

Mini Rev Med Chem 2019 ;19(7):609-621

Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia.

Background: A series of 6, 6'-(1,4-phenylene)bis(4-(4-bromophenyl)pyrimidin-2-amine) derivatives has been synthesized by Claisen-Schmidt condensation and its chemical structures was confirmed by FT-IR, 1H/13C-NMR spectral and elemental analyses. The molecular docking study was carried out to find the interaction between active bis-pyrimidine compounds with CDK-8 protein. The in vitro antimicrobial potential of the synthesized compounds was determined against Gram-positive and Gram-negative bacterial species as well fungal species by tube dilution technique. Read More

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http://dx.doi.org/10.2174/1389557519666181210162413DOI Listing
April 2019
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Activation of AMPK by Medicinal Plants and Natural Products: Its Role in Type 2 Diabetes Mellitus.

Mini Rev Med Chem 2018 Nov 28. Epub 2018 Nov 28.

Departament de Farmacologia, Facultat de Farmàcia, Universitat de València. Spain.

Type-2 diabetes (T2D) is a metabolic disease characterized by permanent hyperglycemia, whose development can be prevented or delayed by using therapeutic agents and implementing lifestyle changes. Some therapeutic alternatives include regulation of glycemia through modulation of different mediators and enzymes, such as AMP-activated protein kinase (AMPK), a highly relevant cellular energy sensor for metabolic homeostasis regulation, with particular relevance in the modulation of liver and muscle insulin sensitivity. This makes it a potential therapeutic target for antidiabetic drugs. Read More

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http://dx.doi.org/10.2174/1389557519666181128120726DOI Listing
November 2018
3 Reads

Molecular Targets, Anti-cancer Properties and Potency of Synthetic Indole-3-carbinol Derivatives.

Mini Rev Med Chem 2019 ;19(7):540-554

Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

The indole-3-carbinol (I3C) displays anti-cancer/proliferative activities against human cancer cells. Cellular proliferation is an event associated with the progress and its continuation. This manifest is described by variation in expression and/or functions of genes that are related with cell cycle relevant proteins. Read More

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http://dx.doi.org/10.2174/1389557518666181116120145DOI Listing
April 2019
12 Reads

Cannabis Associated "High" Cardiovascular Morbidity and Mortality: Marijuana Smoke Like Tobacco Smoke? A déjà vu / déjà vécu story?

Mini Rev Med Chem 2018 Nov 13. Epub 2018 Nov 13.

Third Department of Cardiology, Athens University School of Medicine, Athens. Greece.

Background: Cannabis use has increased over the past several years as some countries have legalized its use for treatment of certain medical conditions and/or for recreational use. Thus, concerns have risen about potential adverse health effects. Increasing number of reports have associated cannabis use with serious cardiovascular (CV) complications. Read More

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http://dx.doi.org/10.2174/1389557518666181114113947DOI Listing
November 2018
20 Reads

Halogenated Compounds from Corals: Chemical Diversity and Biological Activities.

Mini Rev Med Chem 2018 Nov 13. Epub 2018 Nov 13.

Department of Pharmaceutics, Qingdao University of Science and Technology, Qingdao 266042. China.

As important marine biological resources, corals produce a large amount of active organic compounds in their secondary metabolic processes, including numerous brominated, chlorinated, and iodinated compounds. These compounds, with novel structures and unique activities, guide the discovery and research of important lead compounds and novel biological mechanisms. Through large numbers of literature survey, this paper summarized a total of 145 halogenated secondary metabolites which were roughly divided into four major classes of terpenes, prostaglandins, steroids and alkaloids. Read More

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http://dx.doi.org/10.2174/1389557518666181113124015DOI Listing
November 2018
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An Overview of Synthesis of Indole Alkaloids and Biological Activities of Secondary Metabolites Isolated from Hyrtios Species.

Mini Rev Med Chem 2019 ;19(3):194-205

Department of Chemistry, School of Advanced Sciences, VIT, Vellore-632014, Tamil Nadu, India.

Marine sponges are a rich source of more than 50% of marine natural compounds that have been isolated from marine organisms. This review article is focused on the importance of biologically active and pharmaceutically important secondary metabolites extracted from one of the important classes of marine sponge Hyrtios sp. This review also deals with reported synthetic routes of some indole alkaloids extracted from the marine sponge Hyrtios sp. Read More

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http://dx.doi.org/10.2174/1389557518666181102110537DOI Listing
March 2019
10 Reads