2,098 results match your criteria Mini-Reviews in Medicinal Chemistry[Journal]


Synthesis and Molecular Docking of New Thiophene Derivatives as Lactate Dehydrogenase-A Inhibitors.

Mini Rev Med Chem 2019 Feb 12. Epub 2019 Feb 12.

Drug Exploration & Development Chair (DEDC), Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Riyadh 11451. Saudi Arabia.

A series of novel derivatives possessing the thiophene moiety were synthesized using ethyl 5'-amino-2,3'-bithiophene-4'-carboxylate as starting material. The new synthesized derivatives were screened as lactate dehydrogenase (LDH) inhibitors. LDH plays an important role in glucose metabolism in cancer cells and can affect tumor genesis and metastasis. Read More

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http://dx.doi.org/10.2174/1389557519666190212165302DOI Listing
February 2019

Molecular Understanding of the Cardiomodulation in Myocardial Infarction and the Mechanism of Vitamin E Protection.

Mini Rev Med Chem 2019 Jan 30. Epub 2019 Jan 30.

Department of Biochemistry, Faculty of Medicine, UKM Medical Centre, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala Lumpur. Malaysia.

Myocardial infarction is a major cause of deaths globally. Modulation of several molecular mechanisms occur during the initial stages of myocardial ischemia prior to permanent cardiac tissue damage, which involve both pathogenic as well as survival pathways in the cardiomyocyte. Currently, there are increasing evidence regarding the cardioprotective role of vitamin E in alleviating the disease. Read More

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http://dx.doi.org/10.2174/1389557519666190130164334DOI Listing
January 2019

Ultrasound assisted synthesis of 3-(het)aryl isocoumarin derivatives and their in vitro pharmacological evaluation.

Mini Rev Med Chem 2019 Jan 30. Epub 2019 Jan 30.

Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046. India.

In view of numerous biological activities of 3-substituted isocoumarins a number of analogues based on this scaffold were synthesized for their in vitro pharmacological evaluation. Syntheses of these compounds were carried out via a Pd/C-catalyzed Suzuki-Miyaura coupling of 3-chloroisochromen-1-one with a range of boronic acid derivatives. This C-C bond forming reaction was facilitated by ultrasound irradiation to afford the desired products in good yields. Read More

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http://dx.doi.org/10.2174/1389557519666190130163708DOI Listing
January 2019
1 Read

Resveratrol and Its Analogues: Recent Advances in Structural Modification and Bioactivity.

Mini Rev Med Chem 2019 Jan 27. Epub 2019 Jan 27.

School of Biological and Medical Engineering, Hefei University of Technology, Hefei, 230009. China.

Resveratrol is a non-flavonoid polyphenol compound containing terpenoid structure. It has been intensively studied because of its wide variety of promising biological properties, such as anticancer, antioxidant, antibacterial, neuroprotection and anti-inflammatory activities. However, the medicinal application of resveratrol is extremely constrained due to its poor bioavailability and stability. Read More

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http://dx.doi.org/10.2174/1389557519666190128093840DOI Listing
January 2019

Phytochemical profiles and antibacterial activities of Origanum vulgare and Hypericum perforatum and carvacrol and hypericin as a promising anti-Staphylococcus aureus.

Mini Rev Med Chem 2019 Jan 21. Epub 2019 Jan 21.

Razi Herbal Medicines Research Center and Department of Microbiology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad. Iran.

Objectives: Staphylococcus aureus, a Gram-positive bacteria, is ranked second among the causes of hospital infections and is one of the three main causes of food poisoning. In recent times, the spread of antibiotic resistance in S. aureus has become very worrisome. Read More

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http://dx.doi.org/10.2174/1389557519666190121124317DOI Listing
January 2019

Research Progress of Glycyrrhizic Acid on Antiviral Activity.

Mini Rev Med Chem 2019 Jan 18. Epub 2019 Jan 18.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, No.163 Xianlin Road, Nanjing 210023. China.

Glycyrrhizic acid (GA), a triterpene isolated from the roots and rhizomes of licorice, named Glycyrrhiza glabra, is the principal bioactive ingredient of anti-viral, anti-inflammatory and hepatoprotective effects. GA has been used in the clinical treatment of hepatitis, bronchitis, gastric ulcer, AIDS (acquired immunodeficiency syndrome), certain cancers and skin diseases. It has a direct effect on anti-HBV (hepatitis B virus) via affecting the HBsAg (hepatitis B surface antigen) to extracellular secretion, improving liver dysfunction in patients with chronic hepatitis B, and ultimately improving the immune status of HBV. Read More

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http://dx.doi.org/10.2174/1389557519666190119111125DOI Listing
January 2019
18 Reads

Chitosan and its derivatives - biomaterials with diverse biological activity for manifold applications.

Mini Rev Med Chem 2019 Jan 12. Epub 2019 Jan 12.

Tricomed SA, ul. Swietojanska 5/9, 93-493 Lodz. Poland.

Derived from chitin, chitosan a natural polycationic linear polysaccharide is the second the most abundant polymer next to cellulose. The main obstacle in the wide use of chitosan is its almost complete lack of solubility in water and alkaline solutions. To break this obstacles the structure of chitosan is subjected to modification, improving its physic-chemical properties and facilitating application as components of composites or hydrogels. Read More

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http://dx.doi.org/10.2174/1389557519666190112142735DOI Listing
January 2019

Preface.

Authors:
George Perry

Mini Rev Med Chem 2019 ;19(1)

College of Sciences, The University of Texas at San Antonio, Texas, United States.

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http://dx.doi.org/10.2174/138955751901181206141758DOI Listing
January 2019
1 Read

Carbocyclic Analogues of Distamycin and Netropsin.

Mini Rev Med Chem 2019 ;19(2):98-113

Department of Organic Chemistry, Medical University, Bialystok 15-222, Mickiewicza Street 2c, Poland.

The DNA as the depository of genetic information is a natural target for chemotherapy. A lot of anticancer and antimicrobial agents derive their biological activity from their selective interaction with DNA in the minor groove and from their ability to interfere with biological processes such as enzyme catalysis, replication and transcription. The discovery of the details of minor groove binding drugs, such as netropsin and distamycin A, oligoamides built of 4-amino-1-methylpyrrole-2-carboxylic acid residues, allowed to develop various DNA sequence-reading molecules, named lexitropsins, capable of interacting with DNA precisely, strongly and with a high specificity, and at the same time exhibiting significant cytotoxic potential. Read More

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http://dx.doi.org/10.2174/1389557518666181009143203DOI Listing
January 2019
3 Reads

Design, Synthesis and Anticancer Activity of New Thiazole-Tetrazole or Triazole Hybrid Glycosides Targeting CDK-2 via Structure-Based Virtual Screening.

Mini Rev Med Chem 2018 Dec 31. Epub 2018 Dec 31.

Photochemistry Department, National Research Centre, El-Behouth St, Dokki, Cairo. Egypt.

The target tetrazole glycosides were synthesized by construction of ring system by cycloaddition reaction of benzothiazole-linked nitrile derivative and sodium azide followed by N-glycosylation process and deprotection. The triazole glycosides were resulted by applying click approach involving dipolar cycloaddition of benzothiazole possessing alkyne functionality and different glycosyl azides. The products incorporating acyclic analogs of sugar moieties were synthesized through alkylation using acyclic oxygenated halides. Read More

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http://dx.doi.org/10.2174/1389557519666181231121217DOI Listing
December 2018
3 Reads

A Review on Molecular Mechanism of Flavonoids as Antidiabetic Agents.

Mini Rev Med Chem 2018 Dec 27. Epub 2018 Dec 27.

Laboratory of Natural Products, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda (Pb.). India.

The development of drugs possessing anti-diabetic activities is a long pursual goal in drug discovery. It has been shown that deregulated insulin mediated signaling, oxidative stress, obesity, and β-cell dysfunction are the main factors responsible for the disease. With the advent of new and more powerful screening assays and prediction tools, the idea of a drug that can effectively treat diabetes by targeting different pathways has re-bloomed. Read More

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http://dx.doi.org/10.2174/1389557519666181227153428DOI Listing
December 2018

Hybrid molecules development: A versatile landscape for the control of antifungal drug resistance-A Review.

Mini Rev Med Chem 2018 Dec 10. Epub 2018 Dec 10.

Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus, Johannesburg. South Africa.

Hybrid molecule approach of drug design has become popular due to advantages such as delayed resistance, reduced toxicity, ease of treatment of co-infection and lower cost of preclinical evaluation. Antifungal drugs currently available for the treatment of fungal diseases suffer a major side effect of drug resistance. Hybrid drugs development is one of the approaches that has been employed to control microbial resistance. Read More

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http://dx.doi.org/10.2174/1389557519666181210162003DOI Listing
December 2018
1 Read

Design, Synthesis and Therapeutic Potential of some 6, 6'-(1,4-phenylene)bis(4-(4-bromophenyl)pyrimidin-2-amine)analogues.

Mini Rev Med Chem 2018 Dec 10. Epub 2018 Dec 10.

Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan. Malaysia.

A library of 6, 6'-(1,4-phenylene)bis(4-(4-bromophenyl)pyrimidin-2-amine) derivatives has been synthesized by Claisen-Schmidt condensation and its chemical structure was confirmed by FT-IR, 1H/13C-NMR spectral and elemental analyses. The molecular docking study was carried to find the interaction between active bis-pyrimidine compounds with CDK-8 protein. The in vitro antimicrobial potential of the synthesized compounds was determined against Gram-positive and Gram-negative bacteria species as well fungal species by tube dilution technique. Read More

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http://dx.doi.org/10.2174/1389557519666181210162413DOI Listing
December 2018
2 Reads

Activation of AMPK by Medicinal Plants and Natural Products: Its Role in Type 2 Diabetes Mellitus.

Mini Rev Med Chem 2018 Nov 28. Epub 2018 Nov 28.

Departament de Farmacologia, Facultat de Farmàcia, Universitat de València. Spain.

Type-2 diabetes (T2D) is a metabolic disease characterized by permanent hyperglycemia, whose development can be prevented or delayed by using therapeutic agents and implementing lifestyle changes. Some therapeutic alternatives include regulation of glycemia through modulation of different mediators and enzymes, such as AMP-activated protein kinase (AMPK), a highly relevant cellular energy sensor for metabolic homeostasis regulation, with particular relevance in the modulation of liver and muscle insulin sensitivity. This makes it a potential therapeutic target for antidiabetic drugs. Read More

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http://dx.doi.org/10.2174/1389557519666181128120726DOI Listing
November 2018
1 Read

Molecular targets, anti-cancer properties and potency of synthetic indole-3-carbinol derivatives.

Mini Rev Med Chem 2018 Nov 16. Epub 2018 Nov 16.

Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan. Iran.

The indole-3-carbinol (I3C) displays anti-proliferative and anti-cancer activities against human cancer cells. Cellular proliferation is an important event associated with cancer development and continued progression. This manifest is described by altered expression and/or functions of cell cycle related proteins. Read More

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http://dx.doi.org/10.2174/1389557518666181116120145DOI Listing
November 2018
6 Reads

Cannabis Associated "High" Cardiovascular Morbidity and Mortality: Marijuana Smoke Like Tobacco Smoke? A déjà vu / déjà vécu story?

Mini Rev Med Chem 2018 Nov 13. Epub 2018 Nov 13.

Third Department of Cardiology, Athens University School of Medicine, Athens. Greece.

Background: Cannabis use has increased over the past several years as some countries have legalized its use for treatment of certain medical conditions and/or for recreational use. Thus, concerns have risen about potential adverse health effects. Increasing number of reports have associated cannabis use with serious cardiovascular (CV) complications. Read More

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http://dx.doi.org/10.2174/1389557518666181114113947DOI Listing
November 2018
15 Reads

Halogenated Compounds from Corals: Chemical Diversity and Biological Activities.

Mini Rev Med Chem 2018 Nov 13. Epub 2018 Nov 13.

Department of Pharmaceutics, Qingdao University of Science and Technology, Qingdao 266042. China.

As important marine biological resources, corals produce a large amount of active organic compounds in their secondary metabolic processes, including numerous brominated, chlorinated, and iodinated compounds. These compounds, with novel structures and unique activities, guide the discovery and research of important lead compounds and novel biological mechanisms. Through large numbers of literature survey, this paper summarized a total of 145 halogenated secondary metabolites which were roughly divided into four major classes of terpenes, prostaglandins, steroids and alkaloids. Read More

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http://dx.doi.org/10.2174/1389557518666181113124015DOI Listing
November 2018
5 Reads

An Overview of Synthesis of Indole Alkaloids and Biological Activities of Secondary Metabolites Isolated from Hyrtios Species.

Mini Rev Med Chem 2019 ;19(3):194-205

Department of Chemistry, School of Advanced Sciences, VIT, Vellore-632014, Tamil Nadu, India.

Marine sponges are a rich source of more than 50% of marine natural compounds that have been isolated from marine organisms. This review article is focused on the importance of biologically active and pharmaceutically important secondary metabolites extracted from one of the important classes of marine sponge Hyrtios sp. This review also deals with reported synthetic routes of some indole alkaloids extracted from the marine sponge Hyrtios sp. Read More

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http://dx.doi.org/10.2174/1389557518666181102110537DOI Listing
January 2019
5 Reads

Drug Design of Inhibitors of Alzheimer's Disease (AD): POM and DFT Analyses of Cholinesterase Inhibitory Activity of β-amino di-Carbonyl Derivatives.

Mini Rev Med Chem 2018 Nov 1. Epub 2018 Nov 1.

Department of Chemistry, Faculty of Science, University of Cairo, Giza. Egypt.

Background: Since deficit of acetylcholine has been evidenced in the patients of Alzheimer's disease (AD), cholinesterase inhibitors are currently the most prescribed drug class for the treatment of AD.

Results: In the present study, 16 compounds (1-16) with dicarbonyl skeletons have been synthesized and tested for their inhibitory potential in vitro against AChE and BChE using ELISA microtiter plate assays at 100 µg/mL. Since metal accumulation is related to AD, the compounds were also tested for their metal-chelation capacity. Read More

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http://dx.doi.org/10.2174/1389557518666181102102816DOI Listing
November 2018
3 Reads
2.903 Impact Factor

Lemon juice mediated reaction under ultrasound irradiation: synthesis of indolofuroquinoxalines as potential anticancer agents.

Mini Rev Med Chem 2018 Oct 28. Epub 2018 Oct 28.

Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046. India.

A non-hazardous synthetic methodology has been developed for the preparation of compounds based on indolofuroquinoxaline framework. The lemon juice that is known to play the role of a biocatalyst in various organic reactions was used for this purpose. A number of indolofuroquinoxaline derivatives were prepared via the lemon juice mediated condensation of methyl 2-(2-chloro-1H-indol-3-yl)-2-oxoacetate or its N-alkyl derivatives with 1,2-diamines under ultrasound irradiation. Read More

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http://dx.doi.org/10.2174/1389557518666181029100044DOI Listing
October 2018
1 Read

One-Pot Three-Component Synthesis and Molecular Docking of Some Novel 2-Thiazolyl Pyridines as Potent Antimicrobial Agents.

Mini Rev Med Chem 2018 Oct 19. Epub 2018 Oct 19.

Institute of Organic Chemistry, TU-Dresden, Dresden 01062. Germany.

A novel series of 2-thiazolyl pyridines was prepared in a one-pot three-component reaction using 2-bromoacetyl pyridine as a starting precursor. The structure of all products was established on the bases of spectral data and elemental analyses and alternative synthesis if possible. The prepared compounds were screened for their in vitro antimicrobial activity and some derivatives showed promising activity. Read More

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http://dx.doi.org/10.2174/1389557518666181019124104DOI Listing
October 2018
1 Read
2.903 Impact Factor

Molecular concept of diabetic wound healing: effective role of herbal remedies.

Mini Rev Med Chem 2018 Oct 25. Epub 2018 Oct 25.

Universiti Kebangsaan Malaysia Medical Centre - Anatomy Kuala Lumpur. Malaysia.

The incidence of diabetes mellitus (DM) is increasing worldwide. One of the main complications in DM is delayed wound healing which often requires amputation. Various drugs have been used to treat DM but they present with various complications and patients often do not comply with such treatment. Read More

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http://dx.doi.org/10.2174/1389557518666181025155204DOI Listing
October 2018
1 Read

Association between vitamin D levels and nonalcoholic fatty liver disease: potential confounding variables.

Mini Rev Med Chem 2018 Oct 25. Epub 2018 Oct 25.

Institute of Translational Pharmacology, National Research Council, Via Fosso del Cavaliere, 100 00133-Rome. Italy.

Nonalcoholic fatty liver disease (NAFLD), historically considered as the hepatic component of the metabolic syndrome, is a spectrum of fat-associated liver conditions in the absence of secondary causes that may progress to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. Disease progression is closely associated with body weight or fatness, dyslipidemia, insulin resistance, oxidative stress, and inflammation. Recently, there has been a significant scientific interest into the relationship between vitamin D status and NAFLD. Read More

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http://dx.doi.org/10.2174/1389557518666181025153712DOI Listing
October 2018
2 Reads

Insulin-like Growth Factor I Receptor: A Novel Target for Hepatocellular Carcinoma Gene Therapy.

Mini Rev Med Chem 2018 Oct 25. Epub 2018 Oct 25.

Medical School of Nantong University, Nantong 226001. China.

Human insulin-like growth factor (IGF) axis affects the molecular pathogenesis of hepatocellular carcinoma (HCC), especially in the abnormality of hepatic IGF-I receptor (IGF-IR) or IGF-II expression as key molecule in hepatocarcinogenesis. However, the over-expression of hepatic IGF-IR is associated with HCC progression with largely unknown mechanisms. Recently, the IGF-IR as one key molecule of the IGF signal pathway plays an important role in hepatocyte malignant transformation. Read More

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http://dx.doi.org/10.2174/1389557518666181025151608DOI Listing
October 2018
8 Reads
2.900 Impact Factor

A review on quinoline derived scaffolds as Anti-HIV Agents.

Mini Rev Med Chem 2018 Oct 18. Epub 2018 Oct 18.

Department of Pharmaceutical Sciences and Natural Products, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, 151001. India.

After restricting the proliferation of CD4+T cells, Human Immunodeficiency Virus (HIV) infection persists at a very fast rate causing Acquired Immunodeficiency Syndrome (AIDS). This demands the vigorous need of suitable anti-HIV agents, as existing medicines do not provide complete cure and exhibit drawbacks like toxicities, drug resistance, side-effects, etc. Even the introduction of Highly Active Antiretroviral Therapy (HAART) failed to combat HIV/AIDS completely. Read More

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http://dx.doi.org/10.2174/1389557518666181018163448DOI Listing
October 2018
8 Reads
2.903 Impact Factor

Development of New Potential Anticancer Metal Complexes Derived from 2-Hydrazinobenzothiazole.

Mini Rev Med Chem 2018 Oct 17. Epub 2018 Oct 17.

Chemistry Department, Faculty of Science, Mansoura University, Mansoura. Egypt.

Background: Due to the bad side effects of clinically approved anticancer drugs there is a great need to explore and develop new metal-based anticancer drug molecules of high efficiency with less or no side effects.

Objective: To synthesize new metal complexes of 2-hydrazinobenzothiazole (hbt) and to investigate their potential anticancer characteristics.

Method: New five complexes; [VO(hbt)2SO4]. Read More

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http://dx.doi.org/10.2174/1389557518666181017143548DOI Listing
October 2018
10 Reads

Chronic myeloid leukemia: Existing therapeutic options and strategies to overcome drug resistance.

Mini Rev Med Chem 2018 Oct 17. Epub 2018 Oct 17.

Centre for Bioinformatics, School of Life Sciences, Pondicherry University, Kalapet, Puducherry 605014. India.

Chronic myeloid leukemia (CML) is a myeloproliferative disease caused due to translocation between chromosome 9 and 22 leading to chimeric gene product known as Bcr-Abl. Bcr-Abl fusion protein has constitutively activated Abl tyrosine kinase activity which is responsible for the uncontrolled proliferation in CML The tyrosine kinase inhibitors (TKIs) such as Imatinib, Dasatinib, and Nilotinib are the current firstline treatments approved by the United States Food and Drug Administration (US FDA) for the treatment of the disease. Despite the spectacular progress made over the decade with the TKIs, patients develop resistance to these TKIs. Read More

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http://dx.doi.org/10.2174/1389557518666181017124854DOI Listing
October 2018
5 Reads
2.903 Impact Factor

Synthesis, cytotoxicity, antimicrobial and docking simulation of novel pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[3,4-c]pyrimidine derivatives.

Mini Rev Med Chem 2018 Oct 17. Epub 2018 Oct 17.

Department of Chemistry, Faculty of Science, Cairo University, Giza 12613. Egypt.

Isobutyrohydrazonoyl bromide 1 was used as precursor for the synthesis of 4-imino-3-isopropyl-1-(4-nitrophenyl)-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-amine 4, which was converted to hydrazino derivative 5 by heating with hydrazine hydrate at reflux. Hydrazino as well as imino and amino derivatives undergo condensation and cyclization reactions to give pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[3,4-c]pyrimidine derivatives, respectively. Antimicrobial studies are performed using two-gram positive bacteria and two-gram negative bacteria. Read More

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http://dx.doi.org/10.2174/1389557518666181017162459DOI Listing
October 2018
15 Reads

Antimicrobial Effects of Chemical Compounds Isolated from Traditional Chinese Herbal Medicine (TCHM) Against Drug-Resistant Bacteria: A Review Paper.

Mini Rev Med Chem 2019 ;19(2):125-137

China Military Institute of Chinese Medicine, 302 Military Hospital of China, Beijing, 100039, China.

Infectious diseases caused by pathogenic bacteria seriously threaten human lives. Although antibiotic therapy is effective in the treatment of bacterial infections, the overuse of antibiotics has led to an increased risk of antibiotic resistance, putting forward urgent requirements for novel antibacterial drugs. Traditional Chinese herbal medicine (TCHM) and its constituents are considered to be potential sources of new antimicrobial agents. Read More

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http://www.eurekaselect.com/166383/article
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http://dx.doi.org/10.2174/1389557518666181017143141DOI Listing
January 2019
1 Read

Synthesis and Docking Study of Novel 4-Thiazolidinone Derivatives as Anti-Gram-positive and Anti-H. pylori Agents.

Mini Rev Med Chem 2019 ;19(3):239-249

Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Background: Bacterial resistance to the available antibiotics is a life threatening issue and researchers are trying to find new drugs to overcome this problem. Amongst the different structural classes, thiazolidinone-4-one, as a new effective pharmacophore against various bacteria, has been introduced.

Objective: A new series of 2-(5-(5-nitrothiophene-2-yl)-1,3,4-thiadiazole-2-ylimino)-5-arylidenethiazolidin- 4-one derivatives were designed and synthesized as new antibacterial agents. Read More

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http://www.eurekaselect.com/166379/article
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http://dx.doi.org/10.2174/1389557518666181017142630DOI Listing
January 2019
9 Reads

Benzimidazole Derivatives as Potential Antimicrobial and Antiulcer Agents: A Mini Review.

Mini Rev Med Chem 2018 Oct 16. Epub 2018 Oct 16.

Department of Chemistry, Govt Degree College (Boys) Sopore 193201. India.

Here in we report the number of strategies for the synthesis of differently substituted benzimidazole derivatives. The protocols involved in the syntheses of these derivatives were one-pot or multi-component. The characterization studies of these derivatives were carried by using different spectroscopic techniques (1H NMR, 13C NMR and MS) and elemental analyses. Read More

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http://dx.doi.org/10.2174/1381612824666181017102930DOI Listing
October 2018
2 Reads
2.903 Impact Factor

Synthesis and biological activity of 2-amino- and 2-aryl (heteryl) substituted 1,3-benzothiazin-4-ones.

Mini Rev Med Chem 2018 Oct 15. Epub 2018 Oct 15.

Postovsky Institute of Organic Synthesis Ekaterinburg. Russian Federation.

Cyclocondensations based on 2-chlorobenzoamides or 2-halogenobenzoyl isothiocyanates appear to be effective synthetic approaches to 2-cycloalkylimino-substituted 1,3-benzothiazin-4-ones. Some 2-amino- or 2-heteryl-derivatives of 1,3-benzothiazin-4-one are accessible through transformations of 2-mercaptobenzoic acids or 2-chloro-1,3-benzothiazin-4-ones. Synthetic ways to wide range of fluorinated 1,3-benzothiazin-4-ones are summarized. Read More

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http://dx.doi.org/10.2174/1389557518666181015151801DOI Listing
October 2018
2 Reads

Recent Progress of Supercritical Carbon Dioxide in Producing Natural Nanomaterials.

Mini Rev Med Chem 2018 Oct 15. Epub 2018 Oct 15.

School of Materials, The University of Manchester, Manchester M13 9PL. United Kingdom.

Clinical applications of natural active ingredient (NAI) are limited by their instability and poor water solubility, while micronization is one strategy to overcome these drawbacks. Supercritical carbon dioxide (sc-CO2) based nano techniques have drawn great attention in nanomedicinal area for many years, due to their unique characters such as fast mass transfer, near zero surface tension and effective solvents elimination. In terms of functions of sc-CO2, many modified sc-CO2 based techniques are developed to produce NAI nanoparticles. Read More

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http://dx.doi.org/10.2174/1389557518666181015152952DOI Listing
October 2018
10 Reads

Radicals, Oxidative/Nitrosative Stress and Preeclampsia.

Mini Rev Med Chem 2019 ;19(3):178-193

Division of Obstetrics and Gynecology, Golbasi State Hospital, Adiyaman, Turkey.

Preeclampsia (PE) has a profound effect in increasing both maternal and fetal morbidity and mortality especially in third World. Disturbances of extravillous trophoblast migration toward uterine spiral arteries is characteristic feature of PE, which, in turn, leads to increased uteroplacental vascular resistance and by vascular dysfunction resulting in reduced systemic vasodilatory properties. Underlying pathogenesis appeared to be an altered bioavailability of nitric oxide (NO•) and tissue damage caused by increased levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Read More

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http://dx.doi.org/10.2174/1389557518666181015151350DOI Listing
January 2019
12 Reads

A Structural Chemistry Perspective on the Antimalarial Properties of Thiosemicarbazone Metal Complexes.

Mini Rev Med Chem 2018 Oct 15. Epub 2018 Oct 15.

University of Saskatchewan. Canada.

Malaria is a potentially life-threatening disease, affecting approx. 214 million people world-wide. Malaria is caused by protozoan, Plasmodium falciparum, which is transmitted through the Anopheles mosquito. Read More

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http://www.eurekaselect.com/166273/article
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http://dx.doi.org/10.2174/1389557518666181015152657DOI Listing
October 2018
5 Reads

A Review Exploring Therapeutic Worth of 1,3,4-Oxadiazole Tailored Compounds.

Mini Rev Med Chem 2018 Oct 15. Epub 2018 Oct 15.

Jamia Hamdard New Delhi. India.

1,3,4-Oxadiazole ring is an important five-membered aromatic heterocycle widely present in a number of synthetic molecules. The unique structural feature of 1,3,4-oxadiazole ring with pyridine type of nitrogen atom is beneficial for 1,3,4-oxadiazole derivatives to readily bind with a variety of enzymes and receptors in biological systems through diverse weak interactions, thereby exhibiting broad bioactivities. The related research and developments of 1,3,4-oxadiazole-based medicinal chemistry have become a rapidly developing and increasingly active topic. Read More

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http://www.eurekaselect.com/166271/article
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http://dx.doi.org/10.2174/1389557518666181015152433DOI Listing
October 2018
26 Reads
2.903 Impact Factor

2-Mercaptobenzimidazole Schiff Bases: Design, Synthesis, Antimicrobial Studies and Anticancer Activity on HCT-116 Cell Line.

Mini Rev Med Chem 2018 Oct 9. Epub 2018 Oct 9.

Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300 Bandar Puncak Alam, Selangor Darul Ehsan. Malaysia.

Background: Increased rate of mortality due to the development of resistance to currently available antimicrobial and anticancer agents initiated the need to develop new chemical entities for the treatment of microbial infections and cancer.

Objective: The present study was aimed to synthesize and evaluate antimicrobial and anticancer activities of Schiff bases of 2-mercaptobenzimidazole.

Method: The Schiff bases of 2-mercaptobenzimidazole was synthesized from 4-(2-(1H-benzo[d]imidazol-2-ylthio)acetamido)benzohydrazide. Read More

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http://www.eurekaselect.com/166101/article
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http://dx.doi.org/10.2174/1389557518666181009151008DOI Listing
October 2018
2 Reads

Design, Synthesis and Biological Potential of 5-(2-Amino-6-(3/4-bromophenyl)pyrimidin-4-yl)benzene-1,3-diol Scaffolds as Promising Antimicrobial and Anticancer agents.

Mini Rev Med Chem 2018 Oct 9. Epub 2018 Oct 9.

Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan. Malaysia.

Pyrimidine derivatives attracted organic chemists very much due to their biological and chemotherapeutic importance. A series of pyrimidine scaffolds of 5-(2-amino-6-(3/4-bromophenyl)pyrimidin-4-yl)benzene-1,3-diol derivatives was synthesized by Claisen-Schmidt condensation and its chemical structures were confirmed by physicochemical properties and spectral data (NMR, IR, Mass and elemental analyses) study. The synthesized compounds were screened their in vitro antimicrobial activity against bacterial and fungal strains by tube dilution method and anticancer activity against HCT-116 cancer cell line by SRB assay method. Read More

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http://www.eurekaselect.com/166094/article
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http://dx.doi.org/10.2174/1389557518666181009141924DOI Listing
October 2018
3 Reads

Recent Advances in Glyoxalase-I Inhibition.

Mini Rev Med Chem 2018 Oct 9. Epub 2018 Oct 9.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid. Jordan.

Glyoxalase system is a ubiquitous system in human cells which has been examined thoroughly for its role in different disease conditions. It is composed of Glyoxalase-I (Glo-I) and Glyoxalase-II which perform an essential metabolic process inside the cell by detoxifying endogenous harmful metabolites, mainly methylglyoxal (MG) into non-toxic D-lactic acid. Tumor cells are well-known for their high metabolic rate which results in elevated levels of toxic metabolites. Read More

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http://dx.doi.org/10.2174/1389557518666181009141231DOI Listing
October 2018
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Beauvericin, A Fusarium Mycotoxin: Anticancer Activity, Mechanisms, and Human Exposure Risk Assessment.

Mini Rev Med Chem 2019 ;19(3):206-214

Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.

Beauvericin (BEA) is a cyclic hexadepsipeptide, which derives from Cordyceps cicadae. It is also produced by Fusarium species, which are parasitic to maize, wheat, rice and other important commodities. BEA increases ion permeability in biological membranes by forming a complex with essential cations, which may affect ionic homeostasis. Read More

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http://dx.doi.org/10.2174/1389557518666180928161808DOI Listing
January 2019

Azaindole analogues as bioactive agents: Present and future directions.

Mini Rev Med Chem 2018 Sep 28. Epub 2018 Sep 28.

Meerut Institute of Engineering & Technology - Department of Pharmaceutical Technology Meerut, Uttar Pradesh. India.

Azaindoles have been recognized as privileged structures in biological process modulation, in medicinal chemistry and drug discovery programs. Their commercial availability has steadily increased and synthetic innovation has been continuously updated. As in literature, azaindole is a very potent moiety, its derivatives displayed a number of biological activities such as kinase inhibitors, cytotoxic agents, anti-angiogenic activity, CRTh2 receptor antagonists, melanin agonist s, nicotine agonists, effectiveness in alzheimer disease, cytokinin analogs, Orai inhibitors in asthama and chemokine receptor-2 (CCR2) antagonists. Read More

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http://www.eurekaselect.com/165755/article
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http://dx.doi.org/10.2174/1389557518666180928154004DOI Listing
September 2018
14 Reads
2.903 Impact Factor

Phytochemical, Anti-diabetic and Cardiovascular Properties of Urtica dioica L. (Urticaceae): A Review.

Mini Rev Med Chem 2019 ;19(1):63-71

Department of Physiology (Cell Physiology Research Group), University of Extremadura, 10003-Caceres, Spain.

Type 2 diabetes mellitus and cardiovascular diseases (CVD) have become the main cause of morbidity and death worldwide. In addition, current anti-diabetic and cardiovascular therapy is based on conventional drugs that have limited effectiveness and adverse side effects. In this regard, the role of medicinal herbs as a complementary or an alternative medicine is of great interest. Read More

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http://www.eurekaselect.com/165593/article
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http://dx.doi.org/10.2174/1389557518666180924121528DOI Listing
January 2019
2 Reads

Novel Sulfones with Antifungal Properties: Antifungal Activities and Interactions with Candida spp. Virulence Factors.

Mini Rev Med Chem 2019 ;19(1):12-21

Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland.

Since candidiasis is so difficult to eradicate with an antifungal treatment and the existing antimycotics display many limitations, hopefully new sulfone derivatives may overcome these deficiencies. It is pertinent to study new strategies such as sulfone derivatives targeting the virulence attributes of C. albicans that differentiate them from the host. Read More

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http://dx.doi.org/10.2174/1389557518666180924121209DOI Listing
January 2019
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Advances in BPA-induced Oxidative Stress and Related Effects and Mechanisms in liver,1991-2017.

Authors:
Xun Zhang Rutao Liu

Mini Rev Med Chem 2018 Sep 11. Epub 2018 Sep 11.

School of Environmental Science and Engineering, Shandong University, China -America CRC for Environment & Health, Shandong Province, 27# Shanda South Road, Jinan 250100. China.

Bisphenol A (BPA) is an environmental endocrine disruptor widely spreading in life. Its characteristics, including small does, long incubation period, and frequent contact, make it easy to enter human body through drinking water, food, air and other pathways, leading to tumors, infertility, and liver damage. The present review summarizes the underlying mechanism of oxidative stress and its related effects induced by BPA in liver. Read More

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http://dx.doi.org/10.2174/1389557518666180912105345DOI Listing
September 2018
2 Reads

New 1-phthalazinone Scaffold based Compounds: Design, Synthesis, Cytotoxicity and Protein Kinase Inhibition Activity.

Mini Rev Med Chem 2018 ;18(20):1759-1774

University of Science and Technology, Zewail City of Science and Technology, Cairo, 12588, Egypt.

Background & Method: A series of thirty-one new 1-phthalazinones was designed and synthesized based on the well-known VEGFR inhibitor vatalanib. The obtained phthalazinones were screened for their cytotoxic activity against DLD-1 and LoVo (colon), and Panc-1 and Paca-2 (pancreas) cancer cell lines using MTT assay. The tested compounds revealed exceptionally promising cytotoxic activity against LoVo cell lines with IC50 ranges 0. Read More

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http://dx.doi.org/10.2174/1389557518666180903153254DOI Listing
December 2018
9 Reads

Design, Synthesis, SAR Study, Antimicrobial and Anticancer Evaluation of Novel 2-Mercaptobenzimidazole Azomethine Derivatives.

Mini Rev Med Chem 2018 Sep 3. Epub 2018 Sep 3.

Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300 Bandar Puncak Alam, Selangor Darul Ehsan. Malaysia.

Various analogues of benzimidazole are found to be biologically and therapeutically potent against several ailments. Benzimidazole when attached with heterocyclic rings has shown wide range of potential activities. So, from the above provided facts, we altered benzimidazole derivatives so that more potent antagonists could be developed. Read More

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http://dx.doi.org/10.2174/1389557518666180903151849DOI Listing
September 2018
14 Reads

New Trends in Liposome-based Drug Delivery in Colorectal Cancer.

Mini Rev Med Chem 2019 ;19(1):3-11

Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Poland.

Colorectal cancer (CRC) is one of the most common cancers in both men and women. Approximately one-third of patients do not survive five years from diagnosis, which indicates the need for treatment improvement, also through new ways of drug delivery. A possible strategy to increase treatment efficacy is the use of liposomal formulation, which allows delivering both hydrophobic and hydrophilic compounds with better biocompatibility and reduced side-effects. Read More

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http://dx.doi.org/10.2174/1389557518666180903150928DOI Listing
January 2019
9 Reads

Synthesis and Medicinal Applications of N-Aryl-C-nitroazoles.

Mini Rev Med Chem 2018 ;18(20):1733-1752

Saint Petersburg State University, St. Petersburg 199034, Russian Federation.

The review provides a summary of synthetic approaches to and medicinal applications of N-aryl-C-nitroazoles. This broad chemical family delivered numerous practical applications in the areas other than pharmaceuticals. This is most likely due to a common stigma associated with nitroheterocycles implying their inherent toxicity. Read More

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http://dx.doi.org/10.2174/1389557518666180831101841DOI Listing
December 2018
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Chemical compounds produced by Bacillus sp. factories and their role in nature.

Mini Rev Med Chem 2018 Aug 28. Epub 2018 Aug 28.

Facultad de Ciencias Quimicas, Benemerita Universidad Autonoma de Puebla, C.P. 72570, Puebla, Pue.. Mexico.

Microorganisms are able to produce hundreds of unique chemical structures that can be effectively used by the human beings on their own benefit using the products in chemical industry. Bacteria belonging to Bacillus genera are very good chemical factories capable to synthetized different compounds with a wide variety of activities. In this review we try to review the compounds with their respective biological activities produced by different species of Bacillus. Read More

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http://www.eurekaselect.com/164963/article
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http://dx.doi.org/10.2174/1389557518666180829113612DOI Listing
August 2018
6 Reads

Phenols and Polyphenols: Promise and Peril to Human Health.

Mini Rev Med Chem 2018 ;18(15):1242-1243

Department of Biotechnology Engineering Block-II M.M. University Mullana-Ambala-133207, India.

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http://dx.doi.org/10.2174/138955751815180808124616DOI Listing
December 2018
14 Reads