98,615 results match your criteria Minerva chirurgica[Journal]


Respiratory syncytial virus in infants: what's to know.

Minerva Pediatr 2018 Dec;70(6):552

Department of Pediatric Medicine, Bambino Gesù Pediatric Hospital, IRCCS, Rome, Italy.

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December 2018
1 Read

Children engage in competitive altruism.

J Exp Child Psychol 2018 Dec 8;179:176-189. Epub 2018 Dec 8.

Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA.

Humans cultivate their reputations as good cooperators, sometimes even competing with group mates, to appear most cooperative to individuals during the process of selecting partners. To investigate the ontogenetic origins of such "competitive altruism," we presented 5- and 8-year-old children with a dyadic sharing game in which both children simultaneously decided how many rewards to share with each other. The children were either observed by a third-person peer or not. Read More

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December 2018

G3 sports supplement in short triathlon: improvements in training, performance, recovery and oxidative stress.

Minerva Med 2018 Dec;109(6):451-456

CH-PE University, Irvine 3 Labs, Chieti, Italy.

Background: This registry study evaluated the effects of G3 Sports supplement drink (G3) on performance and endurance in triathlon in amateur athletes in a period of 2 weeks of training. G3 is composed of a proprietary fruit juice blend high in carotenoid compounds as well as 100 mg of standardized French oak (Quercus robur) wood extract, Robuvit®, per 50 mL bottle. The antioxidant and anti-inflammatory actions of the compounds in G3 may improve training efficiency (decreasing post-triathlon muscular pain, cramps and improve recovery time) and decrease post-training plasma free radicals (PFR). Read More

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December 2018

Silent somatotropinomas.

Minerva Endocrinol 2018 Dec 7. Epub 2018 Dec 7.

Pathology Department, Hospital General Universitario de Alicante, Alicante, Spain.

Silent somatotroph pituitary neuroendocrine tumors (or silent growth hormone pituitary neuroendocrine tumors, SGH-PitNET) are neoplasias with positive immunostaining for growth hormone (GH), in patients with no signs and symptoms of acromegaly nor biochemical evidence of GH hypersecretion. From a clinical stand-point they are considered and managed as non-functioning pituitary tumors, since they usually come to evidence due to mass-effects (headache, visual impairment, hypopituitarism) or as asymptomatic pituitary incidentalomas. SGH-PitNET have deserved little attention in the medical literature, and no specific guidelines exist regarding their management. Read More

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December 2018

Precision medicine in the treatment of acromegaly.

Minerva Endocrinol 2018 Dec 7. Epub 2018 Dec 7.

Endocrinology Service, Hospital de la Princesa, Madrid, Spain.

Acromegaly is a chronic disorder usually diagnosed late in the disease evolution, leading to substantial morbidity and mortality related to this long period of undiagnosed state as well as the difficulty in achieving normalization of GH hypersecretion and controlling tumour mass. First generation somatostatin analogues (SSA) are accepted as the first-line medical therapy or as second-line therapy in patients undergoing unsuccessful surgery. However, because a high percentage of patients experience SSA treatment failure, the inclusion of biomarkers associated with a successful or non-successful response to these drug ( as well as to all classes of medical therapy) is necessary to better guide the choice of treatment, potentially allowing for a quicker achievement of disease control. Read More

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December 2018

Pathological markers of somatotroph pituitary neuroendocrine tumors (PitNET)s predicting the response to medical treatment.

Minerva Endocrinol 2018 Dec 7. Epub 2018 Dec 7.

Lyon 1, Université de Lyon, Lyon, France -

Acromegaly is mainly due to the somatotroph pituitary neuroendocrine tumors (PitNET)s. These have been subtyped into densely granulated (DG) and sparsely granulated (SG) tumors, which differ in clinical, histological and biological characteristics and in response to somatostatin analogs (SA)s. The variable remission rate after surgical resection, as first line treatment, has increased interest in identifying pathological markers to better predict the response to medical treatment. Read More

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December 2018

Improving effect of vitamin D supplementation on obesity-related diabetes in rats.

Minerva Endocrinol 2018 Dec 7. Epub 2018 Dec 7.

School of Medicine, Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University, Shanghai, P.R. China -

Background: Vitamin D, a fat-soluble secosteroid, plays a key role in several metabolic diseases like diabetes. Diabetes is becoming a third leading chronic disease in the world, which seriously threatens human health.

Methods: In current study, we found the beneficial effects of vitamin D supplementation in obesity-related diabetes rat. Read More

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December 2018

Health care cost analysis of enhanced pacing modalities in bradycardia patients: Portuguese case study on the results of the MINERVA trial.

Rev Port Cardiol 2018 Dec 6. Epub 2018 Dec 6.

University of Florence, Florence, Italy.

Introduction: The MINERVA trial established that atrial preventive pacing and atrial antitachycardia pacing (DDDRP) in combination with managed ventricular pacing (MVP) reduces progression to permanent atrial fibrillation (AF) in patients with paroxysmal or persistent AF and bradycardia who need cardiac pacing, compared to standard dual-chamber pacing (DDDR). It was shown that AF-related health care utilization was significantly lower in the DDDRP + MVP group than in the control group. Cost analysis demonstrated significant savings related to this new algorithm, based on health care costs from the USA, Italy, Spain and the UK. Read More

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December 2018

Complement Factor H and Apolipoprotein E Participate in Regulation of Inflammation in THP-1 Macrophages.

Front Immunol 2018 21;9:2701. Epub 2018 Nov 21.

Department of Bacteriology and Immunology, and Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland.

The alternative pathway (AP) of complement is constantly active in plasma and can easily be activated on self surfaces and trigger local inflammation. Host cells are protected from AP attack by Factor H (FH), the main AP regulator in plasma. Although complement is known to play a role in atherosclerosis, the mechanisms of its contribution are not fully understood. Read More

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November 2018
4 Reads

Teaching the pony new tricks: competences for specialists in laboratory medicine to meet the challenges of disruptive innovation.

Clin Chem Lab Med 2018 Dec 4. Epub 2018 Dec 4.

Department of Laboratory Medicine, Bolton NHS Foundation Trust, Minerva Road, Bolton BL4 0JR, UK.

The 20th century digital revolution has already seen the introduction of faster, more diverse, easier to use technologies with extended capacity and capability that has enhanced productivity in Laboratory Medicine and allowed more effective use of human resource. With increasing demands for better health and best care the challenge to future healthcare systems is to deploy technology, facilities and human resources more effectively. For the 21st century the digital age heralds opportunities for information-led technology providers to become healthcare providers when algorithm driven care can support patients' needs at the point of care close to or in their homes. Read More

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December 2018
1 Read

Evidence for vasopressors during cardiopulmonary resuscitation in newborn infants.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, Alberta, Canada -

An estimated 0.1% of term infants and up to 15% of preterm infants (2-3 million worldwide) need extensive resuscitation, defined as chest compression and 100% oxygen with or without epinephrine in the delivery room. Despite these interventions, infants receiving extensive resuscitation in the DR have a high incidence of mortality and neurologic morbidity. Read More

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December 2018
2 Reads

Enterovirus and Parechovirus infections in children: differences in clinical presentation, mechanisms for meningitis without pleocytosis and mechanisms involved in the neurological outcome.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Pediatrics, Bravis Hospital, Roosendaal, The Netherlands -

Enterovirus (EV) and Parechovirus (HPeV) are a frequent cause of infection in children. This review gives an overview of possible causes for differences in clinical presentation. EV and HPeV can cause a meningitis with or without pleocytosis. Read More

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December 2018
4 Reads

Prognostic significance of expression of Myogenin and OCT4 in glioma.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Pediatric Neurology, Xuzhou Children's Hospital, Xuzhou, Jiangsu, P.R. China -

Background: Glioma is the most common extracranial solid tumor of children. The malignant (cancer) cells form in neural crest cell of the adrenal gland. In this study we investigate the expressions of Myogenin and OCT4 in Glioma which might be used as prognostic makers for this deteriorated disease. Read More

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December 2018
3 Reads

Association between interleukin-10 polymorphisms and juvenile idiopathic arthritis: a meta-analysis.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Korea University College of Medicine, Seoul, Korea -

Introduction: To investigate the IL-10 polymorphisms (-1082 G/A, -819 C/T, and -592 C/A) were associated with susceptibility to JIA.

Evidence Acquisition: A meta-analysis was conducted after database search for relevant articles (MEDLINE and EMBASE).

Evidence Synthesis: A total of seven studies involving 1,495 patients and 1,670 controls were considered in the meta-analysis. Read More

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December 2018
2 Reads

Pediatric total fractionated metanephrine. Age-related reference intervals in spot urine.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Laboratory Medicine and Pathology, Azienda USL of Modena, Modena, Italy.

Background: Sparse metanephrines reference intervals in pediatric populations are available and different study designs and technologies/ assays used in these studies lead to hardly transferable data from a laboratory to another. The objective of the study was to update pediatric reference intervals of total fractionated metanephrines in spot urine samples, using a commercial extraction kit run on a specific high pressure liquid chromatograph coupled with an electrochemical detector.

Methods: 452 spot pediatric urinary samples previously submitted to urinalysis were consecutively included in the study with the exclusion of children's samples with diagnosis or clinical suspicion of paraganglioma/pheochromocytoma, kidney diseases and arterial hypertension. Read More

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December 2018
4 Reads

Metabolic effects of treatment in patients with obstructive sleep apnea: a systematic review.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical, Surgical and Health Sciences, University of Messina, Messina, Italy.

Background: Growth retardation was frequently observed in obstructive sleep apnea (OSA) patients but the complex mechanisms causing this condition are still unclear. Several findings suggested growth catch-up after surgical treatment but other studies did not confirm the results, showing no improvement in OSA patients after adenotonsillectomy (T&A). The aim of the present study was to systematically review scientific literature of the relationships between OSA and metabolic changes involving growth hormone (GH) axis before and after treatment in patients. Read More

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December 2018
1 Read

A rare histopathological lesion of the jaw.

Minerva Stomatol 2018 Dec;67(6):259-260

Unit of Maxillofacial Surgery, Bufalini Hospital, Cesena, Italy.

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December 2018
1 Read

Y-TZP surface behavior under two different milling systems and three different accelerated aging protocols.

Minerva Stomatol 2018 Dec;67(6):237-245

Division of Prosthodontics, Department of Restorative Dentistry, Federal University of Federal University of Rio Grande do Norte (UFRN), Natal, Brazil.

Background: To evaluate the influence of aging and milling system on zirconia surface roughness (SR) and phase transformation.

Methods: Eighty crowns were divided in two groups according to yttria-stabilized tetragonal zirconia polycrystalline (Y-TZP) ceramic milling system (CAD-Neodent or MAD-Zirkonzahn). The crowns were submitted to different aging protocols (N. Read More

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December 2018
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Prediction of dental arch width increase in the early mixed dentition using craniofacial parameters.

Minerva Stomatol 2018 Dec;67(6):231-236

Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: The dimensions of the dental arch have considerable impact on treatment planning. Since the dental arch development has a relationship with the craniofacial growth, we designed a cohort study to find a regression model for predicting the mandibular arch width increase using craniofacial parameters.

Methods: A total of 148 children, all in early mixed dentition, were selected randomly from primary schools by cluster sampling. Read More

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December 2018

In-office and walking bleach dental treatments on endodontically-treated teeth: 25 years follow-up.

Minerva Stomatol 2018 Dec;67(6):225-230

Department of Medicine and Surgery, University of Salerno, Salerno, Italy.

Background: Many techniques have been evolved for the purpose of managing discoloured non-vital tooth such as dental bleaching, restorative and prosthetic treatment. In order to achieve better control on the patients, in-office and intra-coronal bleaching procedures were introduced in clinical practice. Such techniques usually use higher whitening agent concentrations activated by means of heat or light sources, resulting in improved color stability in the long term. Read More

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December 2018

promoted tumor invasion and proliferation via facilitating the phosphorylation of FAK signaling and associated with adverse clinical outcome of non-small cell lung cancer patients.

Onco Targets Ther 2018 25;11:7493-7501. Epub 2018 Oct 25.

Department of Respiratory Medicine, The First Hospital of China Medical University, Shenyang, China.

Background: Family with sequence similarity 129, member B (), also called MINERVA, is upregulated and promotes tumor invasion in multiple types of cancer. However, the mechanism and clinicopathological significance of remains unclear.

Materials And Methods: Online KM-plotter tool and immunohistochemistry were used to predict the prognostic value of expression in lung cancer tissues. Read More

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October 2018
2 Reads

Demographics, tumor characteristics, treatment, and clinical outcomes of patients with ampullary cancer: a surveillance, epidemiology, and end results (SEER) cohort study.

Minerva Gastroenterol Dietol 2018 Nov 27. Epub 2018 Nov 27.

Division of Gastroenterology and Hepatology, School of Medicine Huntsman Cancer Center, University of Utah, Salt Lake City, UT, USA -

Introduction: Ampullary cancer accounts for only 0.2% of GI cancers. The objective of this study was to investigate the incidence, demographics, tumor characteristics, treatment, and survival of patients with ampullary tumors. Read More

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November 2018
1 Read

Signet ring cancer of the gall bladder: a SEER database analysis.

Minerva Gastroenterol Dietol 2018 Nov 27. Epub 2018 Nov 27.

Division of Gastroenterology and Hepatology, School of Medicine Huntsman Cancer Center, University of Utah, Salt Lake City, UT, USA -

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November 2018
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The prevalence of gastroesophageal reflux disease in an adult, South African black population, and the association with obesity.

Minerva Gastroenterol Dietol 2018 Nov 27. Epub 2018 Nov 27.

National Health Laboratory Service, Department of Chemical Pathology, University of the Witwatersrand Medical School, Johannesburg, South Africa.

Background: The aim of the study was to determine the prevalence of gastroesophageal reflux disease (GORD) in a black population in South Africa and to determine if there was any association with obesity.

Methods: A sample of 312 black subjects was randomly selected and interviewed with a structured questionnaire (GerdQ) consisting of six questions translated into English and two of the most commonly used African languages (Zulu and Xhosa). This question-based symptom score for the diagnosis of GORD has been validated previously. Read More

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November 2018
1 Read

Microscopic colitis: a narrative review with clinical approach.

Minerva Gastroenterol Dietol 2018 Nov 21. Epub 2018 Nov 21.

Unit of Gastroenterology, Molinette-SGAS Hospital, Turin, Italy -

Microscopic colitis (MC) is diagnosed in presence of microscopic alterations of colonic mucosa, in patients without macroscopic lesions who referred for chronic diarrhea. The two types of MC are lymphocytic colitis (LC) and collagenous colitis (CC), but it is unclear whether these are the different expression of one unique disease or if they are distinct conditions. Today, although MC represents a consistent health problem, being responsible for a large part of gastroenterological consultations for diarrhea, it remains often underestimated. Read More

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November 2018
7 Reads

Uterine transposition technique: update and review.

Minerva Ginecol 2018 Nov 27. Epub 2018 Nov 27.

Department of Gynecologic Oncology, Instituto Nacional de Cancerología, Bogotá, Colombia.

To review and discuss the uterine transposition technique for preserving fertility in patients who require pelvic radiotherapy. Uterine transposition was developed from adapting well-established surgical techniques with the goal of keeping the uterus and adnexa outside the radiotherapy field in order to preserve their function. The uterine transposition technique is presented step by step, with discussion of the literature that served as the basis for the technique's development. Read More

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November 2018
1 Read

Fetoscopic spina bifida repair.

Minerva Ginecol 2018 Nov 27. Epub 2018 Nov 27.

The Johns Hopkins Center for Fetal Therapy, Department of Gynecology and Obstetrics, Johns Hopkins University, Baltimore, MD, USA.

Introduction: Spina bifida is the most common non-lethal congenital birth defect of the central nervous system that causes chronic disability due to the combined effects of local nerve damage and the sequelae of non-communicating hydrocephalus. This abnormality can be identified early in gestation and the damage can be progressive over the course of pregnancy. Advances in fetal treatment have made minimally invasive prenatal surgery a realistic consideration for spina bifida in order to improve the outcome for children affected this condition. Read More

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November 2018
3 Reads

Cumulative live birth rates in IVF.

Minerva Ginecol 2018 Nov 27. Epub 2018 Nov 27.

Department of Surgical and Clinical Science, Faculty of Medicine and Pharmacy, Vrije Universiteit, Vrije, Brussel.

Introduction: Traditionally, in vitro fertilization (IVF) success rates have been reported in terms of live birth per fresh cycle or embryo transfer. However, reporting IVF outcomes using cumulative live birth rates (LBR), defined as the first live birth following the use of all fresh and frozen embryos derived from a single ovarian stimulation cycle appears to be a better measure of IVF treatment success.

Evidence Acquisition And Synthesis: Although there is an initial increase in fresh LBR with the number of oocytes retrieved, LBR either reach a plateau or may even decline when more than 15-20 oocytes are harvested. Read More

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November 2018

Updates on the management of placenta accreta spectrum.

Minerva Ginecol 2018 Nov 27. Epub 2018 Nov 27.

Women ́s Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway -

Placenta accreta spectrum (PAS) disorders is a multifactorial process that encompasses a heterogeneous group of conditions characterized by an abnormal invasion of trophoblastic tissue through the myometrium and uterine serosa. PAS is associated with a high burden of adverse maternal outcomes including severe life-threatening hemorrhage, need for blood transfusion, damage to adjacent organs, and death. Prenatal screening of PAS is mandatory so that women may be counselled about the severity of this condition to plan management with a multidisciplinary team and delivery in a specialized center. Read More

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November 2018
1 Read

Knowledge and attitudes of midwives regarding reprotoxic agents during pregnancy: snapshot of the Marseille area, southern France.

Minerva Ginecol 2018 Nov 27. Epub 2018 Nov 27.

Aix Marseille Université, Avignon Université, CNRS, IRD, IMBE, Marseille, France. 3 EU3M Ecole Universitaire de Maïeutique Marseille Méditerranée, Marseille, France.

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November 2018

Histological evaluation of the prevalence of adenomyosis, myomas and of their concomitance.

Minerva Ginecol 2018 Nov 27. Epub 2018 Nov 27.

Department of Medical Area, Institute of Obstetrics and Gynecology, University of Udine, Udine, Italy -

Background: The objective of this study is to evaluate the prevalence of adenomyosis, leiomyomas and of their concomitance in women who underwent hysterectomy.

Methods: An observational study carried out on a cohort of 347 women who underwent hysterectomy from a sample of 2383 patients who had gynecological surgery for benign disease in a single University Hospital between 2013 and 2016. An histological evaluation of all surgical specimens was carried out for the presence of adenomyosis and leiomyomas. Read More

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November 2018
1 Read

Structured training program in colorectal surgery: the robotic surgeon as a new paradigm.

Minerva Chir 2018 Nov 21. Epub 2018 Nov 21.

Department of General and Minimally-Invasive Surgery, Misericordia Hospital, Grosseto, Italy.

Background: One major issue in general surgery is how to provide novice surgeons with a structured training program (STP). The aim of our study is to assess the efficacy of a STP in robotic colorectal surgery for young surgeons without prior experience in both open and laparoscopic colorectal surgery, who were autonomous in basic minimally-invasive surgical procedures. Right colectomy with intracorporeal anastomosis has been chosen as a model. Read More

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November 2018

The Video Consulting Emergency (VCE) protocol: a proposition from the World Society of Emergency Surgery members for the initial management of non traumatic acute abdomen.

Minerva Chir 2018 Nov 27. Epub 2018 Nov 27.

Emergency and Trauma Surgery Department, University Hospital of Parma, Parma, Italy.

Background: Our aim is to present the Video-Consulting Emergency (VCE) protocol to improve the decision-making process between an on-site emergency physician and a remote acute care surgeon using a smart phone and the FaceTime application and the Acute Abdominal Decision Making (AADM) model proposed by World Society of Emergency Surgeons members.

Methods: VCE protocol involves emergency physician and the on-call emergency surgeon. Both must be provided a smart phone for 24-hours video-consulting with FaceTime application. Read More

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November 2018

Ex-PRESS glaucoma shunt implantation and trabeculectomy combined with mitomycin C in the treatment of uveitic glaucoma.

Minerva Med 2018 Nov 27. Epub 2018 Nov 27.

Department of Ophthalmology, Harbin Ophthalmology Hospital, Harbin, China.

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November 2018
1 Read

A clinical comparative study of effects of different corneal refractive surgeries on postoperative stability of tear film.

Minerva Med 2018 Nov 27. Epub 2018 Nov 27.

Department of Ophtalmology, Yan'an affiliated Hospital of Kunming Medical University, Kunming, China -

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November 2018
1 Read

Clinical use of cardiac troponin for acute cardiac care and emerging opportunities in the outpatient setting.

Minerva Med 2018 Nov 27. Epub 2018 Nov 27.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.

Cardiac troponin (cTn) testing has evolved significantly in recent times. Because of increased sensitivity, its use has shifted from a marker used solely to help diagnose acute myocardial infarction (MI) to a marker than can be used in the outpatient setting, as well as for both detection of myocardial injury and risk-stratification. Its main role remains in the diagnosis of acute MI and the risk-stratification of patients presenting with suspected acute coronary syndrome. Read More

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November 2018
2 Reads

Bioavailability of a fixed combination of intramuscular diclofenac 75 mg + thiocolchicoside 4 mg single dose vs. single components.

Minerva Med 2018 Nov 27. Epub 2018 Nov 27.

Società Italiana di Farmacocinetica e Biofarmaceutica (S.I.F.E.B.), Pavia, Italy.

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November 2018

Efficacy of diclofenac mesotherapy for the treatment of chronic neck pain in spondylartrosis.

Minerva Med 2018 Nov 27. Epub 2018 Nov 27.

UOC of Physical Medicine and Rehabilitation, Hospital Foundation "Agostino Gemelli", IRCCS, Catholic University of Sacred Heart, Rome, Italy -

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November 2018
5 Reads

Perioperative management of the patient on direct oral anticoagulants: is it time to measure ?

Authors:
Tindaro Mogavero

Minerva Anestesiol 2018 Nov 23. Epub 2018 Nov 23.

Anesthesia and Intensive Care Unit 1, Ospedale S.Chiara, Trento, Italy -

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November 2018

Erector spinae block for parathyroidectomy.

Minerva Anestesiol 2018 Nov 23. Epub 2018 Nov 23.

Department of Surgery, Anesthesia and Intensive Care Section "G.B. Morgagni-Pierantoni" Hospital, Forlì, Italy.

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November 2018

Biomarkers in sepsis: towards precision medicine for the prevention of adverse outcomes.

Minerva Anestesiol 2018 11 23. Epub 2018 Nov 23.

Istituto di Anestesia e Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

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November 2018
1 Read

More salutary effects of intraoperative dexmedetomidine.

Minerva Anestesiol 2018 Nov 23. Epub 2018 Nov 23.

Department of Anesthesiology and Critical Care Medicine, University of New Mexico, Albuquerque, NM, USA -

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November 2018

Intravenous dexmedetomidine: can it modulate the effects of inflammation, or is it only an antinociceptive agent?

Minerva Anestesiol 2018 Nov 23. Epub 2018 Nov 23.

Department of Anesthesia and Perioperative Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain.

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November 2018

Pelvic plexus (PP) block; a new sonographic technique for acute pelvic pain.

Minerva Anestesiol 2018 Nov 23. Epub 2018 Nov 23.

Anatomy Department, Ain Shams University, Cairo, Egypt.

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November 2018

Sleep apnea and cardiovascular complications of the acromegaly. Response to the medical treatment.

Minerva Endocrinol 2018 Nov 26. Epub 2018 Nov 26.

Cardiology Department, University General Hospital of Alicante, Alicante, Spain -

Acromegaly is a rare disease characterized by high levels of growth hormone (GH) and insulin- like growth factor 1 (IGF-1). The excess of GH leads to the development of different manifestations in different organs, from subtle signs in the bones and soft tissues to the development of respiratory and cardiac insufficiency. In the cardiovascular system, the GH/IGF-1 axis exerts its influence on three major aspects: myocyte growth and structure, cardiac contractility and vascular function. Read More

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November 2018
11 Reads

Heterogeneous clinical features of ketosis-prone type 2 diabetes mellitus patients: gender, age, loss of weight and HbA1c.

Minerva Endocrinol 2018 Nov 26. Epub 2018 Nov 26.

Endocrinology Department of Rheumatism, the First People's Hospital of Wujiang, Suzhou, China -

Background: To observe the clinical features of type 2 diabetes mellitus (T2DM) patients with ketosis as the initial symptom, and investigate its differences from clinical features of non-ketotic T2DM patients.

Methods: A total of 385 T2DM patients treated in our hospital from 2014 to 2017 were selected and divided into ketosis-prone T2DM group and non-ketotic T2DM group. Ketosis-prone T2DM patients refer to DM patients with the urine ketone body++ or above or the blood ketone body ≥1. Read More

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November 2018
1 Read

Bone health among patients with primary aldosteronism: a systematic review and meta-analysis.

Minerva Endocrinol 2018 Nov 26. Epub 2018 Nov 26.

Clinical Academic Unit, Newcastle University Medicine Malaysia, Johor, Malaysia.

Background: Recent studies showed a possible association between hyperaldosteronism and secondary hyperparathyroidism leading to reduced bone health, however results are conflicting.

Methods: We conducted a meta-analysis to evaluate the relationship between primary aldosteronism (PA) with bone biochemical markers and to assess bone mineral density in patients with primary aldosteronism.

Results: A total of 939 subjects were examined (37. Read More

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November 2018
1 Read

Monitoring of treament adherence with easypodTM in 6 Italian centres: a real-world experience.

Minerva Endocrinol 2018 Nov 26. Epub 2018 Nov 26.

U.O. Endocrinologia, Azienda Ospedaliera San Camillo-Forlanini, Rome, Italy.

Background: A poor adherence to r-hGH therapy is associated to a low growth rate in patients with growth deficiency. For this reason, the choice of an objective method, such as an electronic device, for monitoring treatment adherence is very important. This retrospective study evaluated the r-hGH treatment adherence of patients with growth deficiency, monitored through the easypodTM device. Read More

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November 2018
1 Read

Novel transcatheter therapies for treating tricuspid regurgitation.

Minerva Cardioangiol 2018 Nov 26. Epub 2018 Nov 26.

Heart Valve Clinic, University Hospital of Zurich, Zurich, Switzerland -

Until recently, tricuspid valve (TV) disease has been relatively neglected for a long time, but recently tricuspid regurgitation (TR) has attracted attention. Although the prognosis of patients with these disorders is poor, the high mortality and morbidity associated with TV surgery have resulted in many patients not receiving surgical therapy. Current guidelines recommend that TV surgery should be considered in patients with severe TR who are symptomatic or have progressive right ventricle (RV) dilatation or dysfunction. Read More

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November 2018
4 Reads