12,229 results match your criteria Minerva Pediatrica [Journal]


"Are perceptual disorder signs in diplegic cerebral palsied children stable over time? A retrospective cohort analysis".

Minerva Pediatr 2019 Apr 16. Epub 2019 Apr 16.

Surgical, Medical and Dental Department of Morphological Sciences related to Transplants Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Reggio Emilia, Italy.

Background: A group of diplegic cerebral palsied (CP) children presents six precise signs that can be easily observed during clinical examinations, physiotherapy sessions and everyday activities. These signs are: startle reaction, upper limbs in startle position, averted-eye gaze, grimaces, eye blinking and posture freezing.

Methods: In a population of 32 diplegic CP children (age 1 - 8 years) perceptual signs were retrospectively identified through videos to verify their stability in the same child over time. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05237-4DOI Listing

Absence of lingual frenulum in children with Ehlers-Danlos Syndrome: a retrospective study of forty cases and literature review of a twenty years long debate.

Minerva Pediatr 2019 04 5. Epub 2019 Apr 5.

Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

Background: Ehlers-Danlos syndrome is part of connective tissue disorders and is characterized by skin hyperextensibility, joint hypermobility, easy bruising and other severe manifestations such as epilepsy, pneumothorax, arterial rupture and bowel perforation. In 2017 a new classification was published, indicating major and minor criteria for each form of EDS. Further reports in the past years tried to determine whether or not the absence of lingual frenulum should be included in minor criteria for the diagnosis of EDS, but a consensus has still not been reached. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05530-0DOI Listing

Influence of prevention of caffeine citrate on cytokine profile and bronchopulmonary dysplasia in preterm infants with apnea.

Minerva Pediatr 2019 Apr 5. Epub 2019 Apr 5.

Intensive Care Unit, Department of Neonatal, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

Background: This study aims to investigate the preventive effects of caffeine citrate on cytokine profile and bronchopulmonary dysplasia (BPD) in preterm infants with apnea.

Methods: Preterm infants with apnea who were born at less than 32 weeks of gestational age and Birth weight≤1500 g were randomly divided into caffeine citrate prevention group and caffeine citrate treatment group. Preterm infants in caffeine citrate prevention group who were at risk of developing recurrent apnea were given to caffeine citrate within 8 h after birth. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05428-8DOI Listing

Epilepsy in Rett syndrome: can seizures play an encephalopathic effect in this disorder?

Minerva Pediatr 2019 Apr 5. Epub 2019 Apr 5.

Department of Medical and Translational Sciences, Child Neuropsychiatry, "Federico II" University of Naples, Naples, Italy.

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http://dx.doi.org/10.23736/S0026-4946.19.05309-XDOI Listing

Hearing loss in methimazole embriopathy: cues form a case.

Minerva Pediatr 2019 Apr 5. Epub 2019 Apr 5.

ENT and Audiology Department, University Hospital of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.23736/S0026-4946.19.05297-6DOI Listing

Weaning in Neurally Adjusted Ventilatory Assist (NAVA): a prospective interventional study in neonates.

Minerva Pediatr 2019 Apr 5. Epub 2019 Apr 5.

Neonatal and Paediatric Intensive Care Unit, Maggiore della Carità Hospital, Novara, Italy.

Background: Neurally adjusted ventilatory assist (NAVA) is a respiratory support triggered by the electrical activity of the diaphragm (EAdi). Only few studies evaluated NAVA short-term efficacy and safety in newborns. Aim of this study is to assess efficacy and safety of NAVA in a cohort of newborns and to analyse ventilation parameters helpful to guide weaning. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A190
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http://dx.doi.org/10.23736/S0026-4946.19.05142-9DOI Listing
April 2019
5 Reads

Non-standard approach to infants and children with megacolon: laparotomy and endorectal pull-through (ERPT) for diagnosis and treatment in difficult countries with low resources in a non-profit setting: return to the past Soave's ERPT.

Minerva Pediatr 2019 Mar 21. Epub 2019 Mar 21.

Paediatric Surgery Unit, Giannina Gaslini Children Hospital and Research Institute, Genoa, Italy.

Background: Hirschsprung's disease is an important cause of pediatric constipation with high risk of bacterial enterocolitis. Its diagnosis is histological and the suction biopsy is the gold standard. In resource-limited countries, the main diagnostic exam is the contrast enema and mini-invasive surgery lacks. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05487-2DOI Listing

The influence of air pollution on respiratory allergies, asthma and wheeze in childhood in Hungary.

Minerva Pediatr 2019 Mar 21. Epub 2019 Mar 21.

Department of Air Hygiene and Aerobiology, National Institute of Public Health, Budapest, Hungary.

Background: Higher exposure to air pollution may contribute to the increased prevalence of allergic diseases in children. The study investigated the associations between the prevalence of childhood respiratory diseases and long-term exposure to NO2, SO2, PM10, furthermore some surrogates in schoolchildren in Hungary. We also analysed the possible modification effects of some confounders by interaction analysis. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05466-5DOI Listing
March 2019
1 Read

Ultrasonography as first line imaging for the diagnosis of positional plagiocephaly: our experience and literature review.

Minerva Pediatr 2019 Mar 21. Epub 2019 Mar 21.

Department of Radiology, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Background: In the last years, numerous studies evaluated different tools for the diagnosis of positional plagiocephaly (PP). The purpose of this study was to evaluate ultrasonography (US) as a first line screening test of lambdoid sutural patency in child with PP and to compare our results with the literature.

Materials And Methods: All consecutive patients who referred to our Institute from January 2016 to October 2017 with the suspicion of PP, were included in the study and performed US examination of the lambdoid sutures. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05424-0DOI Listing

When cough drives you nuts.

Minerva Pediatr 2019 Mar 21. Epub 2019 Mar 21.

Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Pediatric Clinic, University of Verona, Verona, Italy.

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http://dx.doi.org/10.23736/S0026-4946.19.05418-5DOI Listing

Early assessment of weight velocity can support frontline health workers in predicting malnutrition in HIV exposed infants: preliminary results from a dream cohort in Malawi.

Minerva Pediatr 2019 Mar 21. Epub 2019 Mar 21.

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Roma, Italy.

Background: Children born to HIV-positive mothers are particularly susceptible to malnutrition. Currently, monitoring programs rely on punctual anthropometric measurements to assess child growth. Growth velocities could be an additional tool in identifying critical time windows for prevention and implementation of early intervention for malnutrition. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A190
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http://dx.doi.org/10.23736/S0026-4946.19.05417-3DOI Listing
March 2019
3 Reads

Influence of gender and malnutrition on QT dispersion in a north-Malagasy children population.

Minerva Pediatr 2019 Mar 21. Epub 2019 Mar 21.

Service of Pediatrics, Università Campus Bio-Medico di Roma, Roma, Italy.

Background: Children malnutrition involves simultaneous deficiency of nutrients, leading to cardiac morphological and functional alterations. In this complex condition repolarization abnormalities can evolve. Also sexual dimorphism is a well-established phenomenon, but its influence on ventricular repolarization varies tremendously among races. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05190-9DOI Listing

Final adult height in childhood-onset Inflammatory Bowel Disease.

Minerva Pediatr 2019 Mar 21. Epub 2019 Mar 21.

Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.

Background: Long term growth may be compromised in patients with Inflammatory Bowel Disease (IBD). The aims of the study were to evaluate the final height in a cohort of patients with pediatric-onset IBD with respect to genetic target and to determine factors influencing long-term growth.

Methods: This is a monocentric retrospective cohort study. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05183-1DOI Listing
March 2019
1 Read

Pirometaxine™ (Narlisim™) in pediatric nasal congestion: a retrospective study.

Minerva Pediatr 2019 Apr;71(2):110-115

Department of Pediatrics, Garibaldi Hospital, Catania, Italy.

Background: Nasal congestion represents a troublesome health issue which is especially and invalidating in children. Effective nasal drugs, such as sympathomimetic drugs, are usually forbidden in children under 12 years of age because of their potential systemic adverse effects. Hypertonic nasal physiological solutions have recently been successfully used to decongest nasal mucosa in children: its mechanical activity has been universally recognized as safe and effective and it represents a well-established, useful treatment in children. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05225-8DOI Listing
April 2019
1 Read

Personalization of therapies in rare diseases: a translational approach for the treatment of cystic fibrosis.

Minerva Pediatr 2019 Feb 13. Epub 2019 Feb 13.

European Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy -

High variability in the response rates to treatments can make the interpretation of data from clinical trials very difficult, particularly in rare genetic diseases in which the enrolment of thousands of patients is problematic. Personalized medicine largely depends on the establishment of appropriate early detectors of drug efficacy that may guide the administration (or discontinuation) of specific treatments. Such biomarkers should be capable of predicting the therapeutic response of individual patients and of monitoring early benefits of candidate drugs before late clinical benefits become evident. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05511-7DOI Listing
February 2019
3 Reads

Inhaled medications in cystic fibrosis beyond antibiotics.

Minerva Pediatr 2019 Feb 13. Epub 2019 Feb 13.

Department of Translational Medical Sciences, University Federico II, Naples, Italy -

Structural lung disease begins very early in children with Cystic Fibrosis, often in the first three months of life. Inhaled medications represent an attractive therapeutic approach in Cystic Fibrosis that are routinely used as early intervention strategies. Two aerosolized solutions, hypertonic saline and dornase alfa, have significant potential benefits by improving mucociliary clearance, with minimal associated side-effects. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05509-9DOI Listing
February 2019
1 Read

Mutation-specific therapies and drug repositioning in cystic fibrosis.

Minerva Pediatr 2019 Feb 13. Epub 2019 Feb 13.

European Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy -

Cystic Fibrosis (CF) is an inherited, prematurely lethal rare disease affecting more than 85,000 people worldwide. CF is caused by more than 2000 loss-of-function mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR). This review summarizes recent advances in the etiological therapies of CF that aim at repairing the functional defect of CFTR by means of CFTR modulators. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05506-3DOI Listing
February 2019
2 Reads

Efficacy of gummy lozenges containing erysimum as ancillary treatment in children with sore throat.

Minerva Pediatr 2019 Feb 13. Epub 2019 Feb 13.

Pediatri di Famiglia, Federazione Italiana Medici Pediatri (FIMP), Sezione Provinciale di Catania, Catania, Italy.

Background: Sore throat frequently occurs in children aged between 4 and 15 years and is often associated to inflammation of the upper respiratory tract mucosa. A reliable approach to limit the damage caused by inflammation and, therefore, to alleviate associated symptoms might be the protection of the mucosa. Aim of this study was to assess the efficacy and tolerability of a medical device, formulated as a gummy lozenge and containing a combination of natural functional components (erysimum, aloe vera and Xilogel®) able to exert a barrier effect on the mucosa, as ancillary treatment in children with sore throat. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05405-7DOI Listing
February 2019
2 Reads

Association between feeding/mealtime behavior problems and internalizing/externalizing problems in autism spectrum disorder (ASD), other neurodevelopmental disorders (NDDs) and typically developing children.

Minerva Pediatr 2019 Feb 13. Epub 2019 Feb 13.

Child Neuropsychiatry Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari ''Aldo Moro'', Bari, Italy.

Background: The aim of current study was to examine the nature and prevalence of feeding problems and mealtime behavior problems in children with ASD comparing to children with other neurodevelopmental disorders (NNDs) and TD children. We also investigated the impact of intelligence quotient (IQ) and/or emotional and behavioral problems on feeding and mealtime behavior problems.

Methods: Participants completed the following tests: Social Communication Questionnaire (SCQ), Child Behavior Checklist (CBCL), Brief Autism Mealtime Behavior Inventory (BAMBI) and Behavioral Pediatric Feeding Assessment Scale (BPFAS). Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A190
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http://dx.doi.org/10.23736/S0026-4946.19.05371-4DOI Listing
February 2019
15 Reads

To glance on psychiatric comorbidity in adolescent with anorexia nervosa.

Minerva Pediatr 2019 Feb 13. Epub 2019 Feb 13.

Faculty of Educational Science, Suor Orsola Benicasa University, Naples, Italy.

Background: Eating disorders display several psychiatric comorbidities. The aim of this study was to describe these comorbidities in a group of adolescent patients with Anorexia Nervosa or ED- NOS (Eating Disorder not otherwise specified); in detail, we have evaluated the comorbidity both with a clinical interview (categorical comorbidities) and with a self-report interview (dimensional comorbidities) in order to compare the two profiles.

Methods: The study was carried out at the child and adolescent psychiatry division (eating disorder service for developmental age) of the University of Campania "Luigi Vanvitelli" (ex Second University of Naples). Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05202-2DOI Listing
February 2019
2 Reads

Aseptic meningitis as onset of Kawasaki disease.

Minerva Pediatr 2019 Jan 17. Epub 2019 Jan 17.

First Division of Infectious Disease, Cotugno Hospital, Azienda Ospedaliera dei Colli, Naples, Italy.

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http://dx.doi.org/10.23736/S0026-4946.19.05384-2DOI Listing
January 2019
7 Reads

Evaluation of Ki-67 as prognostic factor for pediatric neuroblastoma and the possibility of molecular-targeted drugs with vascular endothelial growth factor and platelet-derived growth factor receptor.

Minerva Pediatr 2019 Jan 2. Epub 2019 Jan 2.

Department of Pediatric Surgery, Fujita Medical University, Toyoake, Japan.

Background: Neuroblastoma (NB) is a pediatric malignant solid tumor characterized as refractory cancer with poor prognosis. Mitosis-karyorrhexis index (MKI) is a prognostic factor but is prone to observer bias. The usefulness of MKI with Ki-67, as a marker of malignancy, was investigated. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05444-0DOI Listing
January 2019
1 Read

Human bocavirus in children with acute gastroenteritis in Piedmont, Italy.

Minerva Pediatr 2019 Jan 2. Epub 2019 Jan 2.

Citoimmunodiagnostics Laboratory, Department of Public Health and Pediatric Sciences, Medical School, University of Turin, Turin, Italy.

Background: Gastroenteritis is a common disease in children, characterized by diarrhea, vomiting, abdominal pain, and fever. Co-detection of HBoV with other gastroenteric viruses was reported a lot in patients with acute gastroenteritis.

Methods: This paper presents the real-time RT-PCR Taqman assay for the detection and quantification of HBoV for clinical fecal samples collected from hospitalized children with acute gastroenteritis in Piedmont. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05365-3DOI Listing
January 2019
12 Reads

Ibuprofen in the treatment of children's inflammatory pain: a clinical and pharmacological overview.

Minerva Pediatr 2019 Feb;71(1):82-99

Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.

Unlike fever, which is often over-treated especially in children, pain is underestimated and under-treated in pediatric age. The pharmacological agents approved for treating pain in these patients are few, also considering the recent limitation for codeine in children younger than 12 years. Paracetamol and the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen are the most used at this purpose. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05453-1DOI Listing
February 2019
8 Reads

When is it useful to act on microbiota in atopic children? A recent experience.

Minerva Pediatr 2019 Feb;71(1):1-3

Unit of Gastroenterology, Department of Medical Sciences, University of Turin, Turin, Italy.

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http://dx.doi.org/10.23736/S0026-4946.18.05425-7DOI Listing
February 2019

Respiratory syncytial virus in infants: what's to know.

Minerva Pediatr 2018 Dec;70(6):552

Department of Pediatric Medicine, Bambino Gesù Pediatric Hospital, IRCCS, Rome, Italy.

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http://dx.doi.org/10.23736/S0026-4946.18.05437-3DOI Listing
December 2018
11 Reads

Evidence for vasopressors during cardiopulmonary resuscitation in newborn infants.

Minerva Pediatr 2019 Apr 3;71(2):159-173. Epub 2018 Dec 3.

Center for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, Canada -

An estimated 0.1% of term infants and up to 15% of preterm infants (2-3 million worldwide) need extensive resuscitation, defined as chest compression and 100% oxygen with or without epinephrine in the delivery room. Despite these interventions, infants receiving extensive resuscitation in the DR have a high incidence of mortality and neurologic morbidity. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05452-XDOI Listing
April 2019
9 Reads

Enterovirus and parechovirus infections in children: differences in clinical presentation, mechanisms for meningitis without pleocytosis and mechanisms involved in the neurological outcome.

Minerva Pediatr 2019 Apr 3;71(2):150-158. Epub 2018 Dec 3.

Department of Pediatrics, Bravis Hospital, Roosendaal, The Netherlands -

Enterovirus (EV) and Parechovirus (HPeV) are a frequent cause of infection in children. This review gives an overview of possible causes for differences in clinical presentation. EV and HPeV can cause a meningitis with or without pleocytosis. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05449-XDOI Listing
April 2019
18 Reads

Prognostic significance of expression of Myogenin and OCT4 in glioma.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Pediatric Neurology, Xuzhou Children's Hospital, Xuzhou, Jiangsu, P.R. China -

Background: Glioma is the most common extracranial solid tumor of children. The malignant (cancer) cells form in neural crest cell of the adrenal gland. In this study we investigate the expressions of Myogenin and OCT4 in Glioma which might be used as prognostic makers for this deteriorated disease. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05396-3DOI Listing
December 2018
15 Reads

Association between interleukin-10 polymorphisms and juvenile idiopathic arthritis: a meta-analysis.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Korea University College of Medicine, Seoul, Korea -

Introduction: To investigate the IL-10 polymorphisms (-1082 G/A, -819 C/T, and -592 C/A) were associated with susceptibility to JIA.

Evidence Acquisition: A meta-analysis was conducted after database search for relevant articles (MEDLINE and EMBASE).

Evidence Synthesis: A total of seven studies involving 1,495 patients and 1,670 controls were considered in the meta-analysis. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05369-0DOI Listing
December 2018
6 Reads

Pediatric total fractionated metanephrine. Age-related reference intervals in spot urine.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Laboratory Medicine and Pathology, Azienda USL of Modena, Modena, Italy.

Background: Sparse metanephrines reference intervals in pediatric populations are available and different study designs and technologies/ assays used in these studies lead to hardly transferable data from a laboratory to another. The objective of the study was to update pediatric reference intervals of total fractionated metanephrines in spot urine samples, using a commercial extraction kit run on a specific high pressure liquid chromatograph coupled with an electrochemical detector.

Methods: 452 spot pediatric urinary samples previously submitted to urinalysis were consecutively included in the study with the exclusion of children's samples with diagnosis or clinical suspicion of paraganglioma/pheochromocytoma, kidney diseases and arterial hypertension. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05319-7DOI Listing
December 2018
17 Reads

Metabolic effects of treatment in patients with obstructive sleep apnea: a systematic review.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical, Surgical and Health Sciences, University of Messina, Messina, Italy.

Background: Growth retardation was frequently observed in obstructive sleep apnea (OSA) patients but the complex mechanisms causing this condition are still unclear. Several findings suggested growth catch-up after surgical treatment but other studies did not confirm the results, showing no improvement in OSA patients after adenotonsillectomy (T&A). The aim of the present study was to systematically review scientific literature of the relationships between OSA and metabolic changes involving growth hormone (GH) axis before and after treatment in patients. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05223-4DOI Listing
December 2018
1 Read

Comparison of the Fitbit® Charge and polysomnography for measuring sleep quality in children with sleep disordered breathing.

Minerva Pediatr 2018 Nov 7. Epub 2018 Nov 7.

Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital, Columbus, OH, USA.

Background: Due to the cost and inconvenience of polysomnography (PSG), wristworn accelerometers have been explored as an alternative method to measure sleep efficacy in children with obstructive sleep apnea (OSA) or sleep-disordered breathing (SDB). We compared the measurement of sleep quality with the Fitbit® Charge compared to PSG in children presenting for sleep studies.

Methods: Children ages 3 to 18 years, presenting for PSG with persistent SDB symptoms were enrolled. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05333-1DOI Listing
November 2018
6 Reads

Steroid- and immunosuppressant-based protocol of Henoch-Schönlein purpura nephritis without angiotensin inhibitors in the acute phase: case series with correlation to histology.

Minerva Pediatr 2018 Nov 7. Epub 2018 Nov 7.

Ichinomiya Medical Treatment & Habilitation Center, Ichinomiya-city, Aichi, Japan -

Background: The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines suggest initially using angiotensin-converting-enzyme inhibitors (ACE-Is) and/or angiotensin receptor blockers (ARBs) to treat Henoch-Schönlein purpura nephritis (HSPN). However, these guidelines might overlook the potential benefits of aggressive therapy. Therefore, we evaluated the efficacy of an HSPN protocol that primarily uses steroids and immunosuppressants, without ACE-Is or ARBs. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05324-0DOI Listing
November 2018
17 Reads

Targeting bacterial biofilms in pulmonary diseases in pediatric population.

Minerva Pediatr 2018 Nov 7. Epub 2018 Nov 7.

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Australia.

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05256-8DOI Listing
November 2018
12 Reads

Intrasphincteric BoTox injections in Hirschsprung's disease: indications and outcome in 64 procedures over a ten-year period.

Minerva Pediatr 2018 Nov 7. Epub 2018 Nov 7.

Department of Pediatric Surgery, Giannina Gaslini Children's Hospital, Institute for Scientific Research, Genoa, Italy.

Background: Intrasphincteric Botulinum toxin (BoTox) injection for symptomatic postoperative anal achalasia in Hirschsprung's disease (HSCR) has found wide application in the last twenty years. The aim of this study is to describe effectiveness and functional outcome of a series of patients treated over a 10-year period.

Methods: All consecutive HSCR patients who received intrasphincteric BoTox injections between January 2007 and December 2016 were included. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05238-6DOI Listing
November 2018
3 Reads

Early monitoring of fatty acid profile in children with attention deficit and/or hyperactivity disorder under treatment with omega-3 polyunsaturated fatty acids.

Minerva Pediatr 2018 Nov 7. Epub 2018 Nov 7.

Department of Pediatrics, School of Medicine, San Cecilio University Hospital, University of Granada, Granada, Spain.

Background: Cognitive effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) might make them helpful in attention deficit / hyperactivity disorder (ADHD). However, the results derived from supplementation studies in children depend on the respective combinations and the study period. We aimed to investigate the serum fatty acid profile, attention scores and the tolerability in a group of ADHD children after receiving methylphenidate (MPH) and ω-3 PUFAs for 1 month. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.04975-7DOI Listing
November 2018
9 Reads

RSV infection and respiratory sequelae.

Minerva Pediatr 2018 Dec 29;70(6):623-633. Epub 2018 Oct 29.

Unit of Neonatal Intensive Care, Department of Woman's and Child's Health, University of Padua, Padua, Italy.

Introduction: The association between respiratory syncytial virus (RSV) infections and long-term respiratory sequelae has long been recognized. It is estimated that individuals with a history of RSV bronchiolitis have 2- to 12-fold higher risk of developing asthma. Although this risk tends to decrease with age, persistent airway obstruction and hyperresponsiveness are observed even 30 years after RSV infection. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05327-6DOI Listing
December 2018
28 Reads

The management of hepatitis B and hepatitis C in children.

Minerva Pediatr 2019 Feb 18;71(1):59-75. Epub 2018 Oct 18.

Division of Pediatric Gastroenterology, Nutrition, and Hepatology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA -

In the present paper, we review the increased disease burden of hepatitis B (HBV) and hepatitis C (HCV) infection that is recognized worldwide; especially in children when the most common mode of transmission is vertically from infected mothers. In children with HBV and HCV infection, spontaneous clearance of the virus in the first years of life is not common, in contrast with adults, but these patients often stay asymptomatic until early adulthood, when disease has progressed to chronic hepatitis with increased risk of cirrhosis and its complication, and hepatocellular carcinoma. Due to limited treatment options of HBV infection in the pediatric population, clinicians focus on primary prevention, by vaccinating all infants during their first days of life. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05410-5DOI Listing
February 2019
34 Reads
0.723 Impact Factor

The infant with severe bronchiolitis: from high flow nasal cannula to continuous positive airway pressure and mechanical ventilation.

Minerva Pediatr 2018 Dec 18;70(6):612-622. Epub 2018 Oct 18.

Division of Anesthesia and Intensive Care, Department of Pediatrics, Children's Hospital Vittore Buzzi, ASST FBF Sacco, Milan, Italy.

Bronchiolitis is one of the most frequent reasons for Pediatric Intensive Care Unit (PICU) admission in children less than 1 year of age. It causes a wide spectrum of clinical scenarios from mild to severe respiratory failure and supportive therapy range from high flow nasal cannula (HFNC) to nonconventional ventilation and extra corporeal membrane oxygenation (ECMO) in the most severe forms. Aim of this article is to review the available ventilation mode in children with bronchiolitis and the scientific evidence. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05358-6DOI Listing
December 2018
6 Reads

Bronchiolitis clinics and medical treatment.

Minerva Pediatr 2018 Dec 18;70(6):600-611. Epub 2018 Oct 18.

Department of Pediatrics, Sapienza University, Rome, Italy.

Bronchiolitis is the most common acute lower respiratory tract infection in infants and the first cause of hospitalization in this age group. Despite it has been studied for over 70 years, its management remains controversial and nowadays the treatment is only supportive. Pediatricians should be well acquainted with the clinical course of the disease. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05334-3DOI Listing
December 2018
12 Reads

Respiratory syncytial virus prophylaxis and the "special population".

Minerva Pediatr 2018 Dec 18;70(6):589-599. Epub 2018 Oct 18.

Unit of Paediatric Pulmonology and Respiratory Intermediate Care, Academic Department of Paediatrics, Paediatric Hospital "Bambino Gesù" Research Institute, Rome, Italy.

Bronchiolitis is the most frequent airway infection in the first 2 years of life, and the respiratory syncytial virus (RSV) is the most frequently responsible virus. In selected high-risk groups, RSV may cause severe respiratory disease leading to hospitalization, need for mechanical ventilation, and even death. These high-risk groups include children with congenital heart disease, infants with neuromuscular impairment, cystic fibrosis, Down Syndrome, immunodeficiency syndromes and others specific conditions. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05316-1DOI Listing
December 2018
3 Reads

Respiratory syncytial virus.

Minerva Pediatr 2018 Dec 18;70(6):553-565. Epub 2018 Oct 18.

Laboratory of Virology, Department of Molecular Medicine, Sapienza University, Rome, Italy.

Respiratory syncytial virus (RSV) is the most common cause of infant hospitalization and causes a high burden of disease in the elderly, too. This enveloped negative-stranded RNA virus has been recently reclassified in the Pneumoviridae family. Infections of the respiratory cells happens when the two major surface glycoproteins, G and F, take contact with the cell receptor CX3CR1 and mediate entry by fusion, respectively. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05312-4DOI Listing
December 2018
1 Read

Active prophylaxis for respiratory syncytial virus: current knowledge and future perspectives.

Minerva Pediatr 2018 Dec 18;70(6):566-578. Epub 2018 Oct 18.

Unit of Pediatric Infectious Diseases, Department of Pediatrics, Bambino Gesù Children's Hospital (OPBG), Rome, Italy.

Respiratory syncytial virus (RSV) is the most common respiratory pathogen in infants and young children but represents also an important cause of morbidity in adults, particularly in the elderly and immunocompromised persons. Despite its global impact on human health, no effective treatment is available except for supportive care and no safe vaccine has been licensed yet. Vaccine development has been hindered by several factors including vaccine enhanced disease associated with formalin-inactivated RSV vaccine, ethical concerns and lack of consensus concerning the most appropriate target antigen. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05305-7DOI Listing
December 2018
15 Reads

RSV prophylaxis in premature infants.

Minerva Pediatr 2018 Dec 18;70(6):579-588. Epub 2018 Oct 18.

Department of Translational Medical Sciences, ''Federico II'' University, Naples, Italy.

Infants born prematurely before 37 weeks of gestational age (GA) have particular anatomical, immunological and metabolic characteristics that predispose them, even in the absence of diseases at birth, to severe morbidity. Respiratory syncytial virus (RSV) is the leading cause of hospitalization for lower respiratory tract infections (LRTI) in the first year of life, as well as an important cause of respiratory outcomes as recurrent wheezing in industrialized countries or mortality in developing countries. Prematurity is an important risk factor for hospitalization for severe RSV disease, but epidemiological, environmental and demographic risk factors also play a role in RSV infection. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05300-8DOI Listing
December 2018
22 Reads

Comparison between infantile hepatic hemangioendothelioma and hepatoblastoma in pediatric patients: clinical manifestations and contrast-enhanced computed tomography features.

Minerva Pediatr 2018 10;70(5):497-498

Department of Radiology, The Affiliated Hospital of Qingdao, University of Qingdao, Qingdao, China -

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https://www.minervamedica.it/index2.php?show=R15Y2018N05A049
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http://dx.doi.org/10.23736/S0026-4946.17.04919-2DOI Listing
October 2018
3 Reads
0.723 Impact Factor

Amoxicillin/clavulanic acid-induced exfoliative dermatitis in a child.

Minerva Pediatr 2018 10;70(5):495-496

Allergy Unit, Department of Pediatrics, Anna Meyer Children's University Hospital, Florence, Italy.

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https://www.minervamedica.it/index2.php?show=R15Y2018N05A049
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http://dx.doi.org/10.23736/S0026-4946.17.04845-9DOI Listing
October 2018
88 Reads

A rare cause of fever of unknown origin: hypohidrotic ectodermal dysplasia with a splice site mutation.

Minerva Pediatr 2018 10;70(5):493-495

Department of Pediatrics, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.

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https://www.minervamedica.it/index2.php?show=R15Y2018N05A049
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http://dx.doi.org/10.23736/S0026-4946.17.04817-4DOI Listing
October 2018
17 Reads

Mononucleosis-related fatigue: supplementary management with Robuvit®.

Minerva Pediatr 2018 10;70(5):425-429

IRVINE3 Labs, Department of Medical and Oral Sciences, and Biotechnologies, G. D'Annunzio University, Chieti-Pescara, Italy.

Background: Infectious mononucleosis (IM) is a common disease of adolescents and young adults, characterized by a specific triad of symptoms represented by fever, sore throat and lymphadenopathy. IM may also affect older adults, with different, more intense signs and symptoms such as fatigue, general malaise, and diffuse body pain. The aim of this four-week-registry study was to evaluate the effects of Robuvit® supplementation on the main consequences of mononucleosis, particularly fatigue, in otherwise healthy adults. Read More

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https://www.minervamedica.it/index2.php?show=R15Y2018N05A042
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http://dx.doi.org/10.23736/S0026-4946.18.05213-1DOI Listing
October 2018
17 Reads