12,215 results match your criteria Minerva Pediatrica [Journal]


Personalization of therapies in rare diseases: a translational approach for the treatment of cystic fibrosis.

Minerva Pediatr 2019 Feb 13. Epub 2019 Feb 13.

European Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy -

High variability in the response rates to treatments can make the interpretation of data from clinical trials very difficult, particularly in rare genetic diseases in which the enrolment of thousands of patients is problematic. Personalized medicine largely depends on the establishment of appropriate early detectors of drug efficacy that may guide the administration (or discontinuation) of specific treatments. Such biomarkers should be capable of predicting the therapeutic response of individual patients and of monitoring early benefits of candidate drugs before late clinical benefits become evident. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05511-7DOI Listing
February 2019

Inhaled medications in cystic fibrosis beyond antibiotics.

Minerva Pediatr 2019 Feb 13. Epub 2019 Feb 13.

Department of Translational Medical Sciences, University Federico II, Naples, Italy -

Structural lung disease begins very early in children with Cystic Fibrosis, often in the first three months of life. Inhaled medications represent an attractive therapeutic approach in Cystic Fibrosis that are routinely used as early intervention strategies. Two aerosolized solutions, hypertonic saline and dornase alfa, have significant potential benefits by improving mucociliary clearance, with minimal associated side-effects. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05509-9DOI Listing
February 2019

Mutation-specific therapies and drug repositioning in cystic fibrosis.

Minerva Pediatr 2019 Feb 13. Epub 2019 Feb 13.

European Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy -

Cystic Fibrosis (CF) is an inherited, prematurely lethal rare disease affecting more than 85,000 people worldwide. CF is caused by more than 2000 loss-of-function mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR). This review summarizes recent advances in the etiological therapies of CF that aim at repairing the functional defect of CFTR by means of CFTR modulators. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05506-3DOI Listing
February 2019

Efficacy of gummy lozenges containing erysimum as ancillary treatment in children with sore throat.

Minerva Pediatr 2019 Feb 13. Epub 2019 Feb 13.

Pediatri di Famiglia, Federazione Italiana Medici Pediatri (FIMP), Sezione Provinciale di Catania, Catania, Italy.

Background: Sore throat frequently occurs in children aged between 4 and 15 years and is often associated to inflammation of the upper respiratory tract mucosa. A reliable approach to limit the damage caused by inflammation and, therefore, to alleviate associated symptoms might be the protection of the mucosa. Aim of this study was to assess the efficacy and tolerability of a medical device, formulated as a gummy lozenge and containing a combination of natural functional components (erysimum, aloe vera and Xilogel®) able to exert a barrier effect on the mucosa, as ancillary treatment in children with sore throat. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05405-7DOI Listing
February 2019

Association between feeding/mealtime behavior problems and internalizing/externalizing problems in autism spectrum disorder (ASD), other neurodevelopmental disorders (NDDs) and typically developing children.

Minerva Pediatr 2019 Feb 13. Epub 2019 Feb 13.

Child Neuropsychiatry Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari ''Aldo Moro'', Bari, Italy.

Background: The aim of current study was to examine the nature and prevalence of feeding problems and mealtime behavior problems in children with ASD comparing to children with other neurodevelopmental disorders (NNDs) and TD children. We also investigated the impact of intelligence quotient (IQ) and/or emotional and behavioral problems on feeding and mealtime behavior problems.

Methods: Participants completed the following tests: Social Communication Questionnaire (SCQ), Child Behavior Checklist (CBCL), Brief Autism Mealtime Behavior Inventory (BAMBI) and Behavioral Pediatric Feeding Assessment Scale (BPFAS). Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A190
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http://dx.doi.org/10.23736/S0026-4946.19.05371-4DOI Listing
February 2019
4 Reads

To glance on psychiatric comorbidity in adolescent with anorexia nervosa.

Minerva Pediatr 2019 Feb 13. Epub 2019 Feb 13.

Faculty of Educational Science, Suor Orsola Benicasa University, Naples, Italy.

Background: Eating disorders display several psychiatric comorbidities. The aim of this study was to describe these comorbidities in a group of adolescent patients with Anorexia Nervosa or ED- NOS (Eating Disorder not otherwise specified); in detail, we have evaluated the comorbidity both with a clinical interview (categorical comorbidities) and with a self-report interview (dimensional comorbidities) in order to compare the two profiles.

Methods: The study was carried out at the child and adolescent psychiatry division (eating disorder service for developmental age) of the University of Campania "Luigi Vanvitelli" (ex Second University of Naples). Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05202-2DOI Listing
February 2019

Aseptic meningitis as onset of Kawasaki disease.

Minerva Pediatr 2019 Jan 17. Epub 2019 Jan 17.

First Division of Infectious Disease, Cotugno Hospital, Azienda Ospedaliera dei Colli, Naples, Italy.

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http://dx.doi.org/10.23736/S0026-4946.19.05384-2DOI Listing
January 2019
3 Reads

Evaluation of Ki-67 as prognostic factor for pediatric neuroblastoma and the possibility of molecular-targeted drugs with vascular endothelial growth factor and platelet-derived growth factor receptor.

Minerva Pediatr 2019 Jan 2. Epub 2019 Jan 2.

Department of Pediatric Surgery, Fujita Medical University, Toyoake, Japan.

Background: Neuroblastoma (NB) is a pediatric malignant solid tumor characterized as refractory cancer with poor prognosis. Mitosis-karyorrhexis index (MKI) is a prognostic factor but is prone to observer bias. The usefulness of MKI with Ki-67, as a marker of malignancy, was investigated. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05444-0DOI Listing
January 2019
1 Read

Human bocavirus in children with acute gastroenteritis in Piedmont, Italy.

Minerva Pediatr 2019 Jan 2. Epub 2019 Jan 2.

Citoimmunodiagnostics Laboratory, Department of Public Health and Pediatric Sciences, Medical School, University of Turin, Turin, Italy.

Background: Gastroenteritis is a common disease in children, characterized by diarrhea, vomiting, abdominal pain, and fever. Co-detection of HBoV with other gastroenteric viruses was reported a lot in patients with acute gastroenteritis.

Methods: This paper presents the real-time RT-PCR Taqman assay for the detection and quantification of HBoV for clinical fecal samples collected from hospitalized children with acute gastroenteritis in Piedmont. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05365-3DOI Listing
January 2019
7 Reads

Ibuprofen in the treatment of children's inflammatory pain: a clinical and pharmacological overview.

Minerva Pediatr 2019 Feb;71(1):82-99

Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.

Unlike fever, which is often over-treated especially in children, pain is underestimated and under-treated in pediatric age. The pharmacological agents approved for treating pain in these patients are few, also considering the recent limitation for codeine in children younger than 12 years. Paracetamol and the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen are the most used at this purpose. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05453-1DOI Listing
February 2019
1 Read

When is it useful to act on microbiota in atopic children? A recent experience.

Minerva Pediatr 2019 Feb;71(1):1-3

Unit of Gastroenterology, Department of Medical Sciences, University of Turin, Turin, Italy.

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http://dx.doi.org/10.23736/S0026-4946.18.05425-7DOI Listing
February 2019

Respiratory syncytial virus in infants: what's to know.

Minerva Pediatr 2018 Dec;70(6):552

Department of Pediatric Medicine, Bambino Gesù Pediatric Hospital, IRCCS, Rome, Italy.

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http://dx.doi.org/10.23736/S0026-4946.18.05437-3DOI Listing
December 2018
6 Reads

Evidence for vasopressors during cardiopulmonary resuscitation in newborn infants.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, Alberta, Canada -

An estimated 0.1% of term infants and up to 15% of preterm infants (2-3 million worldwide) need extensive resuscitation, defined as chest compression and 100% oxygen with or without epinephrine in the delivery room. Despite these interventions, infants receiving extensive resuscitation in the DR have a high incidence of mortality and neurologic morbidity. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05452-XDOI Listing
December 2018
3 Reads

Enterovirus and Parechovirus infections in children: differences in clinical presentation, mechanisms for meningitis without pleocytosis and mechanisms involved in the neurological outcome.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Pediatrics, Bravis Hospital, Roosendaal, The Netherlands -

Enterovirus (EV) and Parechovirus (HPeV) are a frequent cause of infection in children. This review gives an overview of possible causes for differences in clinical presentation. EV and HPeV can cause a meningitis with or without pleocytosis. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05449-XDOI Listing
December 2018
9 Reads

Prognostic significance of expression of Myogenin and OCT4 in glioma.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Pediatric Neurology, Xuzhou Children's Hospital, Xuzhou, Jiangsu, P.R. China -

Background: Glioma is the most common extracranial solid tumor of children. The malignant (cancer) cells form in neural crest cell of the adrenal gland. In this study we investigate the expressions of Myogenin and OCT4 in Glioma which might be used as prognostic makers for this deteriorated disease. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05396-3DOI Listing
December 2018
10 Reads

Association between interleukin-10 polymorphisms and juvenile idiopathic arthritis: a meta-analysis.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Korea University College of Medicine, Seoul, Korea -

Introduction: To investigate the IL-10 polymorphisms (-1082 G/A, -819 C/T, and -592 C/A) were associated with susceptibility to JIA.

Evidence Acquisition: A meta-analysis was conducted after database search for relevant articles (MEDLINE and EMBASE).

Evidence Synthesis: A total of seven studies involving 1,495 patients and 1,670 controls were considered in the meta-analysis. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05369-0DOI Listing
December 2018
5 Reads

Pediatric total fractionated metanephrine. Age-related reference intervals in spot urine.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Laboratory Medicine and Pathology, Azienda USL of Modena, Modena, Italy.

Background: Sparse metanephrines reference intervals in pediatric populations are available and different study designs and technologies/ assays used in these studies lead to hardly transferable data from a laboratory to another. The objective of the study was to update pediatric reference intervals of total fractionated metanephrines in spot urine samples, using a commercial extraction kit run on a specific high pressure liquid chromatograph coupled with an electrochemical detector.

Methods: 452 spot pediatric urinary samples previously submitted to urinalysis were consecutively included in the study with the exclusion of children's samples with diagnosis or clinical suspicion of paraganglioma/pheochromocytoma, kidney diseases and arterial hypertension. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05319-7DOI Listing
December 2018
11 Reads

Metabolic effects of treatment in patients with obstructive sleep apnea: a systematic review.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical, Surgical and Health Sciences, University of Messina, Messina, Italy.

Background: Growth retardation was frequently observed in obstructive sleep apnea (OSA) patients but the complex mechanisms causing this condition are still unclear. Several findings suggested growth catch-up after surgical treatment but other studies did not confirm the results, showing no improvement in OSA patients after adenotonsillectomy (T&A). The aim of the present study was to systematically review scientific literature of the relationships between OSA and metabolic changes involving growth hormone (GH) axis before and after treatment in patients. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05223-4DOI Listing
December 2018
1 Read

Comparison of the Fitbit® Charge and polysomnography for measuring sleep quality in children with sleep disordered breathing.

Minerva Pediatr 2018 Nov 7. Epub 2018 Nov 7.

Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital, Columbus, OH, USA.

Background: Due to the cost and inconvenience of polysomnography (PSG), wristworn accelerometers have been explored as an alternative method to measure sleep efficacy in children with obstructive sleep apnea (OSA) or sleep-disordered breathing (SDB). We compared the measurement of sleep quality with the Fitbit® Charge compared to PSG in children presenting for sleep studies.

Methods: Children ages 3 to 18 years, presenting for PSG with persistent SDB symptoms were enrolled. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05333-1DOI Listing
November 2018
6 Reads

Steroid- and immunosuppressant-based protocol of Henoch-Schönlein purpura nephritis without angiotensin inhibitors in the acute phase: case series with correlation to histology.

Minerva Pediatr 2018 Nov 7. Epub 2018 Nov 7.

Ichinomiya Medical Treatment & Habilitation Center, Ichinomiya-city, Aichi, Japan -

Background: The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines suggest initially using angiotensin-converting-enzyme inhibitors (ACE-Is) and/or angiotensin receptor blockers (ARBs) to treat Henoch-Schönlein purpura nephritis (HSPN). However, these guidelines might overlook the potential benefits of aggressive therapy. Therefore, we evaluated the efficacy of an HSPN protocol that primarily uses steroids and immunosuppressants, without ACE-Is or ARBs. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05324-0DOI Listing
November 2018
14 Reads

Targeting bacterial biofilms in pulmonary diseases in pediatric population.

Minerva Pediatr 2018 Nov 7. Epub 2018 Nov 7.

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Australia.

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05256-8DOI Listing
November 2018
7 Reads

Intrasphincteric BoTox injections in Hirschsprung's disease: indications and outcome in 64 procedures over a ten-year period.

Minerva Pediatr 2018 Nov 7. Epub 2018 Nov 7.

Department of Pediatric Surgery, Giannina Gaslini Children's Hospital, Institute for Scientific Research, Genoa, Italy.

Background: Intrasphincteric Botulinum toxin (BoTox) injection for symptomatic postoperative anal achalasia in Hirschsprung's disease (HSCR) has found wide application in the last twenty years. The aim of this study is to describe effectiveness and functional outcome of a series of patients treated over a 10-year period.

Methods: All consecutive HSCR patients who received intrasphincteric BoTox injections between January 2007 and December 2016 were included. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05238-6DOI Listing
November 2018
2 Reads

Early monitoring of fatty acid profile in children with attention deficit and/or hyperactivity disorder under treatment with omega-3 polyunsaturated fatty acids.

Minerva Pediatr 2018 Nov 7. Epub 2018 Nov 7.

Department of Pediatrics, School of Medicine, San Cecilio University Hospital, University of Granada, Granada, Spain.

Background: Cognitive effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) might make them helpful in attention deficit / hyperactivity disorder (ADHD). However, the results derived from supplementation studies in children depend on the respective combinations and the study period. We aimed to investigate the serum fatty acid profile, attention scores and the tolerability in a group of ADHD children after receiving methylphenidate (MPH) and ω-3 PUFAs for 1 month. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.04975-7DOI Listing
November 2018
9 Reads

RSV infection and respiratory sequelae.

Minerva Pediatr 2018 Dec 29;70(6):623-633. Epub 2018 Oct 29.

Unit of Neonatal Intensive Care, Department of Woman's and Child's Health, University of Padua, Padua, Italy.

Introduction: The association between respiratory syncytial virus (RSV) infections and long-term respiratory sequelae has long been recognized. It is estimated that individuals with a history of RSV bronchiolitis have 2- to 12-fold higher risk of developing asthma. Although this risk tends to decrease with age, persistent airway obstruction and hyperresponsiveness are observed even 30 years after RSV infection. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05327-6DOI Listing
December 2018
22 Reads

The management of hepatitis B and hepatitis C in children.

Minerva Pediatr 2019 Feb 18;71(1):59-75. Epub 2018 Oct 18.

Division of Pediatric Gastroenterology, Nutrition, and Hepatology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA -

In the present paper, we review the increased disease burden of hepatitis B (HBV) and hepatitis C (HCV) infection that is recognized worldwide; especially in children when the most common mode of transmission is vertically from infected mothers. In children with HBV and HCV infection, spontaneous clearance of the virus in the first years of life is not common, in contrast with adults, but these patients often stay asymptomatic until early adulthood, when disease has progressed to chronic hepatitis with increased risk of cirrhosis and its complication, and hepatocellular carcinoma. Due to limited treatment options of HBV infection in the pediatric population, clinicians focus on primary prevention, by vaccinating all infants during their first days of life. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05410-5DOI Listing
February 2019
26 Reads
0.723 Impact Factor

The infant with severe bronchiolitis: from high flow nasal cannula to continuous positive airway pressure and mechanical ventilation.

Minerva Pediatr 2018 Dec 18;70(6):612-622. Epub 2018 Oct 18.

Division of Anesthesia and Intensive Care, Department of Pediatrics, Children's Hospital Vittore Buzzi, ASST FBF Sacco, Milan, Italy.

Bronchiolitis is one of the most frequent reasons for Pediatric Intensive Care Unit (PICU) admission in children less than 1 year of age. It causes a wide spectrum of clinical scenarios from mild to severe respiratory failure and supportive therapy range from high flow nasal cannula (HFNC) to nonconventional ventilation and extra corporeal membrane oxygenation (ECMO) in the most severe forms. Aim of this article is to review the available ventilation mode in children with bronchiolitis and the scientific evidence. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05358-6DOI Listing
December 2018
4 Reads

Bronchiolitis clinics and medical treatment.

Minerva Pediatr 2018 Dec 18;70(6):600-611. Epub 2018 Oct 18.

Department of Pediatrics, Sapienza University, Rome, Italy.

Bronchiolitis is the most common acute lower respiratory tract infection in infants and the first cause of hospitalization in this age group. Despite it has been studied for over 70 years, its management remains controversial and nowadays the treatment is only supportive. Pediatricians should be well acquainted with the clinical course of the disease. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05334-3DOI Listing
December 2018
11 Reads

Respiratory syncytial virus prophylaxis and the "special population".

Minerva Pediatr 2018 Dec 18;70(6):589-599. Epub 2018 Oct 18.

Unit of Paediatric Pulmonology and Respiratory Intermediate Care, Academic Department of Paediatrics, Paediatric Hospital "Bambino Gesù" Research Institute, Rome, Italy.

Bronchiolitis is the most frequent airway infection in the first 2 years of life, and the respiratory syncytial virus (RSV) is the most frequently responsible virus. In selected high-risk groups, RSV may cause severe respiratory disease leading to hospitalization, need for mechanical ventilation, and even death. These high-risk groups include children with congenital heart disease, infants with neuromuscular impairment, cystic fibrosis, Down Syndrome, immunodeficiency syndromes and others specific conditions. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05316-1DOI Listing
December 2018
2 Reads

Respiratory syncytial virus.

Minerva Pediatr 2018 Dec 18;70(6):553-565. Epub 2018 Oct 18.

Laboratory of Virology, Department of Molecular Medicine, Sapienza University, Rome, Italy.

Respiratory syncytial virus (RSV) is the most common cause of infant hospitalization and causes a high burden of disease in the elderly, too. This enveloped negative-stranded RNA virus has been recently reclassified in the Pneumoviridae family. Infections of the respiratory cells happens when the two major surface glycoproteins, G and F, take contact with the cell receptor CX3CR1 and mediate entry by fusion, respectively. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05312-4DOI Listing
December 2018
1 Read

Active prophylaxis for respiratory syncytial virus: current knowledge and future perspectives.

Minerva Pediatr 2018 Dec 18;70(6):566-578. Epub 2018 Oct 18.

Unit of Pediatric Infectious Diseases, Department of Pediatrics, Bambino Gesù Children's Hospital (OPBG), Rome, Italy.

Respiratory syncytial virus (RSV) is the most common respiratory pathogen in infants and young children but represents also an important cause of morbidity in adults, particularly in the elderly and immunocompromised persons. Despite its global impact on human health, no effective treatment is available except for supportive care and no safe vaccine has been licensed yet. Vaccine development has been hindered by several factors including vaccine enhanced disease associated with formalin-inactivated RSV vaccine, ethical concerns and lack of consensus concerning the most appropriate target antigen. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05305-7DOI Listing
December 2018
9 Reads

RSV prophylaxis in premature infants.

Minerva Pediatr 2018 Dec 18;70(6):579-588. Epub 2018 Oct 18.

Department of Translational Medical Sciences, ''Federico II'' University, Naples, Italy.

Infants born prematurely before 37 weeks of gestational age (GA) have particular anatomical, immunological and metabolic characteristics that predispose them, even in the absence of diseases at birth, to severe morbidity. Respiratory syncytial virus (RSV) is the leading cause of hospitalization for lower respiratory tract infections (LRTI) in the first year of life, as well as an important cause of respiratory outcomes as recurrent wheezing in industrialized countries or mortality in developing countries. Prematurity is an important risk factor for hospitalization for severe RSV disease, but epidemiological, environmental and demographic risk factors also play a role in RSV infection. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05300-8DOI Listing
December 2018
16 Reads

Comparison between infantile hepatic hemangioendothelioma and hepatoblastoma in pediatric patients: clinical manifestations and contrast-enhanced computed tomography features.

Minerva Pediatr 2018 10;70(5):497-498

Department of Radiology, The Affiliated Hospital of Qingdao, University of Qingdao, Qingdao, China -

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https://www.minervamedica.it/index2.php?show=R15Y2018N05A049
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http://dx.doi.org/10.23736/S0026-4946.17.04919-2DOI Listing
October 2018
3 Reads
0.723 Impact Factor

Amoxicillin/clavulanic acid-induced exfoliative dermatitis in a child.

Minerva Pediatr 2018 10;70(5):495-496

Allergy Unit, Department of Pediatrics, Anna Meyer Children's University Hospital, Florence, Italy.

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https://www.minervamedica.it/index2.php?show=R15Y2018N05A049
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http://dx.doi.org/10.23736/S0026-4946.17.04845-9DOI Listing
October 2018
69 Reads

A rare cause of fever of unknown origin: hypohidrotic ectodermal dysplasia with a splice site mutation.

Minerva Pediatr 2018 10;70(5):493-495

Department of Pediatrics, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.

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https://www.minervamedica.it/index2.php?show=R15Y2018N05A049
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http://dx.doi.org/10.23736/S0026-4946.17.04817-4DOI Listing
October 2018
13 Reads

Mononucleosis-related fatigue: supplementary management with Robuvit®.

Minerva Pediatr 2018 10;70(5):425-429

IRVINE3 Labs, Department of Medical and Oral Sciences, and Biotechnologies, G. D'Annunzio University, Chieti-Pescara, Italy.

Background: Infectious mononucleosis (IM) is a common disease of adolescents and young adults, characterized by a specific triad of symptoms represented by fever, sore throat and lymphadenopathy. IM may also affect older adults, with different, more intense signs and symptoms such as fatigue, general malaise, and diffuse body pain. The aim of this four-week-registry study was to evaluate the effects of Robuvit® supplementation on the main consequences of mononucleosis, particularly fatigue, in otherwise healthy adults. Read More

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https://www.minervamedica.it/index2.php?show=R15Y2018N05A042
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http://dx.doi.org/10.23736/S0026-4946.18.05213-1DOI Listing
October 2018
13 Reads

Proteinuria in children with autosomal dominant polycystic kidney disease.

Minerva Pediatr 2018 Oct;70(5):413-417

nd Faculty of Medicine, Charles University Prague, Motol University Hospital, Prague, Czech Republic.

Background: Proteinuria is a common complication in adults with autosomal dominant polycystic kidney disease (ADPKD) and serves as a risk factor for progression. However, proteinuria has rarely been examined in children with ADPKD and the type of proteinuria has not yet been investigated. The aim of the study was to assess the prevalence and to analyse the types of proteinuria in children with ADPKD. Read More

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https://www.minervamedica.it/index2.php?show=R15Y2018N05A041
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http://dx.doi.org/10.23736/S0026-4946.16.04404-2DOI Listing
October 2018
3 Reads

Outcomes of infants born near term: not quite ready for the "big wide world"?

Minerva Pediatr 2019 Feb 4;71(1):47-58. Epub 2018 Oct 4.

Neonatal Unit, University Hospitals of Leicester NHS Trust, Leicester, UK -

Until recently, there has been a strongly held belief on the part of neonatal and pediatric clinicians that outcomes for infants born close to term are not different from those of babies born at full term. In the last decade, however, this assumption has been challenged by reports suggesting that this is not correct, and highlighting differences in morbidity and mortality both in the short and long term. This has led to development of new terminology to more accurately reflect the impact of immaturity associated with birth at 32-33 weeks (moderately preterm) and 34-36 weeks (late preterm) of gestation. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05406-3DOI Listing
February 2019
10 Reads

Helicobacter pylori infection in children with portal hypertensive gastropathy: a clear indication for clinical practice.

Minerva Pediatr 2018 Oct 4. Epub 2018 Oct 4.

Pediatric Gastroenterology Unit, Department of Pediatrics, Azienda Ospedaliera-Universitaria Citta della Salute e della Scienza di Torino, University of Turin, Turin, Italy.

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http://dx.doi.org/10.23736/S0026-4946.18.05395-1DOI Listing
October 2018
1 Read

Lifestyle factors among adolescent.

Minerva Pediatr 2018 Dec 4;70(6):642-643. Epub 2018 Oct 4.

Alcohological Regional Center, Ligurian Region, ASL3 c/o IRCCS San Martino Polyclinic Hospital, Genoa, Italy -

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https://www.minervamedica.it/index2.php?show=R15Y2018N06A064
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http://dx.doi.org/10.23736/S0026-4946.18.05386-0DOI Listing
December 2018
2 Reads

New medical device coating mouth gel for temporary relief of teething symptoms: a pilot randomised, open-label, controlled study.

Minerva Pediatr 2018 Oct 4. Epub 2018 Oct 4.

University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.

Background: This study verified the feasibility of the monthly recruitment rate, tested the Face, Legs, Activity, Cry and Consolability Pain Assessment Tool (FLACC) for pain in infants and collected preliminary efficacy and safety data of a new proprietary oral gel formulation of high-molecularweight hyaluronan (HMWHA) for the relief of teething. Results will support the design a future main trial vs local anaesthetic, that is currently the only clinically proven pain reliever.

Methods: This was a pilot, randomised, controlled, multicentre, open-label, parallel-group trial. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05360-4DOI Listing
October 2018
3 Reads

A study on the effect of joint detection of biochemical markers and electrophysiological examination in the early diagnosis of children with Green-Barre syndrome.

Minerva Pediatr 2018 Oct 4. Epub 2018 Oct 4.

Department of Neurology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Children's Hospital, Zhengzhou, P.R. China -

Background: To investigate the effect of early diagnosis in children with GreenBarre syndrome (GBS) via joint detection of biochemical markers and electrophysiological examination.

Methods: A total of 90 children with (GBS collected from the Department of Neurology, intensive care unit (ICU), Rehabilitation Department of Cerebral Palsy of Children's Hospital Affiliated to Zhengzhou University, Department of Pediatrics of First Affiliated Hospital of Zhengzhou University and Henan Province People's Hospital were selected as the research objects. According to their onset time, they were divided into group A (n=30) hospitalized within 3 days of onset, group B (n=30) hospitalized from 4 to 7 days of onset, and group C (n=30) hospitalized after more than 7 days of onset. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05313-6DOI Listing
October 2018
2 Reads

The numerical value of fluid balance to predict survival in neonates requiring extracorporeal membrane oxygenation.

Minerva Pediatr 2018 Oct 4. Epub 2018 Oct 4.

Pediatric Intensive Care Unit, Affiliated Bayi Children's Hospital, PLA Army General Hospital, Southern Medical University, Beijing, China.

Background: To understand numerical variation of fluid balance in neonates requiring Extracorporeal membrane oxygenation (ECMO) and to assess the relationship between hourly fluid balance and mortality.

Methods: This is a prospective cohort study. All neonates supported by ECMO were enrolled from October 2011 to September 2017. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05301-XDOI Listing
October 2018
3 Reads

Increased parental perception of sleep disordered breathing in a cohort of infants with ALTE/BRUE events.

Minerva Pediatr 2018 Oct 4. Epub 2018 Oct 4.

Department of Pediatrics, University of Insubria, Varese, Italy.

Background: An apparent life-threatening event (ALTE) describes an acute, unexpected change in an infant's breathing, aspect, or behavior frightening to the parent or caretaker. According to the new recent terminology, clinicians should use the term Brief Resolved Unexplained Event (BRUE) to describe an event occurring in an infant <1 year of age when the observer reports a sudden, brief, and now resolved episode. The aims of the present study in infants were: to investigate sleep disturbances in both ALTE event and after their classification according the new BRUE criteria. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05276-3DOI Listing
October 2018
2 Reads

Impact of dance therapy on children with specific learning disability: a two arm cluster randomized control study on Italian sample.

Minerva Pediatr 2018 Oct 4. Epub 2018 Oct 4.

Department of Life, Health and Environmental Science, University of L'Aquila, L'Aquila, Italy.

Background: Dance Therapy can improve the quality of life for a person with several conditions, especially psychological wellbeing and quality of life, in the short and longterm. The aim of the study was to examine the effects of the Dance Therapy (DT) on specific learning disability (SLD) children. We wanted to test the impact on cognitive and emotional patterns on children with learning disorders. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05249-0DOI Listing
October 2018
2 Reads

Respiratory syncytial virus infection in cardiac patients: outcomes preordained by il-6 gene polymorphism?

Minerva Pediatr 2018 Oct 4. Epub 2018 Oct 4.

Division of Pediatrics and Neonatology, Moscati Hospital, Aversa, Caserta, Italy -

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05236-2DOI Listing
October 2018
2 Reads

Meeting nutritional needs of infants under 3 months of life within the first week after cardiovascular surgery.

Minerva Pediatr 2018 Oct 4. Epub 2018 Oct 4.

Hospital de Pediatria SAMIC, Juan P. Garrahan, CABA, Argentina.

Background: After heart surgery requiring cardiopulmonary bypass, neonates have a profound metabolic response to stress. If adequate nutritional support is not provided this leads to loss of lean mass and deterioration of vital organs. Our objective was to describe the nutritional status and nutritional support achieved in infants younger than 3 months of life undergo in cardiovascular surgery. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05200-3DOI Listing
October 2018
2 Reads

Clinical use of Basophil Activation Test (BAT) in drug, food and hymenoptera venom allergies.

Minerva Pediatr 2018 Oct 4. Epub 2018 Oct 4.

Pediatric Clinic, Foundation IRCCS Policlinic San Matteo, University of Pavia, Pavia, Italy.

The basophil activation is emerging as a reliable and robust in vitro biomarker of in vivo allergy reactions. Basophil Activation Test (BAT), intended as in vitro stimulation of patient blood basophil with allergens, followed by flow cytometric detection and quantification of such activation, is nowadays a well-established assay in a growing number of routine diagnostic labs. The advancements in the standardization of BAT testing and first convincing clinical evidence are behind this spreading of the assay in clinical lab. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05144-7DOI Listing
October 2018
18 Reads

The comparison of skin prick test, serological specific IgE test and solid phase immunoassay in the diagnosis of infantile allergic diseases.

Minerva Pediatr 2018 Jul 24. Epub 2018 Jul 24.

Department of Primary Child Care, Children's Hospital, Chongqing Medical University, Chongqing, China -

Background: This retrospective study was designed in order to compare the usefulness of skin prick tests, serological specific IgE tests and solid phase immunoassays in the diagnosis of infantile allergic diseases.

Methods: Two hundred infants with allergic diseases (120 infants with eczema and 80 infants with asthma), diagnosed in the Pediatric Clinic of our hospital between June of 2011 and June of 2016, were selected to participate in the study. 100 healthy infants were included in a control group. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05199-XDOI Listing
July 2018
7 Reads

Serum levels of LH, IGF-1 and leptin in girls with idiopathic central precocious puberty (ICPP) and the correlations with the development of ICPP.

Minerva Pediatr 2018 Jul 24. Epub 2018 Jul 24.

Department of Paediatrics, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, P.R. China.

Background: This paper aims to investigate the correlation between serum levels of luteinizing hormone (LH), insulin-like growth factor-1 (IGF-1) and leptin and the incidence of idiopathic central precocious puberty (ICPP) in girls, and to explore the clinical values in the diagnosis of ICPP.

Methods: A total of 48 girls with ICPP were selected in our hospital from March 2014 to March 2015 to serve as ICPP group. At the same time, 48 girls with the same age distribution were selected as control group. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05069-7DOI Listing
July 2018
8 Reads