15,843 results match your criteria Milroy Disease


Subclinical Lymphedema After Treatment for Breast Cancer: Risk of Progression and Considerations for Early Intervention.

Ann Surg Oncol 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: Breast cancer-related lymphedema (BCRL) is a devastating complication of breast cancer (BC) treatment. The authors hypothesized that identifying subclinical lymphedema (SCL) presents an opportunity to prevent BCRL development. They aimed to assess rates of SCL progression (relative volume change [RVC], 5-10%) to BCRL (RVC, ≥10%) in women undergoing axillary surgery for BC via axillary lymph node dissection (ALND) or sentinel lymph node biopsy (SLNB). Read More

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Advances in Lymphedema.

Circ Res 2021 Jun 10;128(12):2003-2016. Epub 2021 Jun 10.

Allan and Tina Neill Professor of Lymphatic Research and Medicine, Stanford University School of Medicine, Stanford, CA.

Lymphedema is a common, complex, and inexplicably underappreciated human disease. Despite a history of relative neglect by health care providers and by governmental health care agencies, the last decade has seen an explosive growth of insights into, and approaches to, the problem of human lymphedema. The current review highlights the significant advances that have occurred in the investigative and clinical approaches to lymphedema, particularly over the last decade. Read More

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Patient-Reported Outcome Measures With Secondary Lower Limb Lymphedemas: A Systematic Review.

J Adv Pract Oncol 2021 Mar 1;12(2):174-187. Epub 2021 Mar 1.

University of Applied Sciences for Health Professions Upper Austria, Steyr, Austria.

Background: Patient-reported outcome measures are measures of patients' health-related quality of life. They should be added to other lymphedema measurements. With an improved disease-free survival of secondary lower limb lymphedema, attention must focus on such assessments. Read More

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Evaluation and Management of Patients with Leg Swelling: Therapeutic Options for Venous Disease and Lymphedema.

Semin Intervent Radiol 2021 Jun 3;38(2):189-193. Epub 2021 Jun 3.

Division of Interventional Radiology, Department of Radiology, Weill Cornell Medical College, New York, New York.

Lower extremity swelling is a common condition which has a variety of etiologies and can be challenging to diagnose and manage. Swelling is usually the result of the accumulation of interstitial fluid in the subcutaneous tissues. Common etiologies include systemic, superficial, and deep venous, and lymphatic disorders. Read More

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Treatment of end-stage lymphedema following radiotherapy for lymphoma: A case report.

Medicine (Baltimore) 2021 May;100(19):e25871

Department of Plastic Surgery, Korea University College of Medicine, Seoul, South Korea.

Rationale: : Despite significant advances in microsurgical techniques, simultaneous vascularized lymph node transfer (VLNT) and lymphovenous anastomosis (LVA) surgeries may be effective for treatment of end-stage lymphedema. This case report describes the successful treatment of end-stage lymphedema with VLNT and LVA.

Patient Concerns: A 72-year-old patient with bilateral lower extremity lymphedema was referred to our lymphedema clinic. Read More

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Loco-regional therapy and the risk of breast cancer-related lymphedema: a systematic review and meta-analysis.

Breast Cancer 2021 Jun 9. Epub 2021 Jun 9.

Department of Breast Disease, Peking Union Medical College Hospital, Peking Union Medical College, 1 Shuaifuyuan, Wangfujing, Beijing, 100730, China.

Background: This meta-analysis was designed to assess the association between two loco-regional therapies, regional nodal irradiation (RNI) and axillary lymph node dissection (ALND), and breast cancer-related lymphoedema (BCRL).

Methods: We searched PubMed, Science Direct, Embase, and BMJ databases for clinical studies published between January 1, 2010 and January 1, 2020, which assessed risk factors and incidence/prevalence of BCRL. Two investigators independently selected articles to extract relative data and calculate corresponding exact binomial 95% confidence intervals (CIs). Read More

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Evaluation of pentoxifylline and ferrous sulfate for treatment of lower limb venous ulcers.

J Vasc Bras 2021 May 24;20:e2020167. Epub 2021 May 24.

Universidade Federal de Pernambuco - UFPE, Recife, PE, Brasil.

Background: Venous ulcers (VU) are the most advanced stage of chronic venous disease (CVD) of the lower limbs. They are frequently associated with episodes of hemorrhage that can provoke chronic anemia (CA), delaying healing. There are no studies in the literature analyzing the prevalence of CA among patients with VU of the lower limbs and few studies have analyzed use of pentoxifylline to treat VU of the lower limbs. Read More

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Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema.

Nat Commun 2021 06 8;12(1):3460. Epub 2021 Jun 8.

Department of Physiology, Semmelweis University School of Medicine, Budapest, Hungary.

Lack or dysfunction of the lymphatics leads to secondary lymphedema formation that seriously reduces the function of the affected organs and results in degradation of quality of life. Currently, there is no definitive treatment option for lymphedema. Here, we utilized nucleoside-modified mRNA encapsulated in lipid nanoparticles (LNPs) encoding murine Vascular Endothelial Growth Factor C (VEGFC) to stimulate lymphatic growth and function and reduce experimental lymphedema in mouse models. Read More

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A family with Milroy disease caused by the FLT4/VEGFR3 gene variant c.2774 T > A.

BMC Med Genomics 2021 Jun 8;14(1):151. Epub 2021 Jun 8.

Key Laboratory of Reproductive Health and Medical Genetics, Liaoning Province Research Institute of Family Planning, China Medical University, 10 Puhe Street, Huanggu District, Shenyang, 110031, Liao Ning Province, China.

Background: Milroy disease (MD) is a rare, autosomal-dominant disorder. Variants in the Fms-related tyrosine kinase 4 (FLT4/VEGFR3) gene cause the symptoms of this disease. In this report, we investigated the variant in a large Chinese family with MD. Read More

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The Learning Curve: Trends in the First 100 Immediate Lymphatic Reconstructions Performed at a Single Institution.

Ann Plast Surg 2021 Jun;86(6S Suppl 5):S495-S497

Department of Women's Oncology, Breast Program, Moffitt Cancer Center, Tampa, FL.

Background: Cancer-related lymphedema will affect 10% to 50% of breast cancer survivors. Early data show that immediate lymphatic reconstruction may help prevent breast cancer lymphedema; however, the details have not been fully elucidated. The purpose of this study was to evaluate the cohort of our first 100 patients for trends in demographics, treatment, and technique. Read More

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Quality of life in long term survivors of cervical cancer: A cross sectional study.

Indian J Cancer 2021 Apr-Jun;58(2):171-178

Department of Gynecological Oncology, Tata Memorial Centre, Homi Bhabha National University, Mumbai, Maharashtra, India.

Background: Quality of life (QOL) is an important parameter to evaluate and modify in patients treated for cervical cancer as long-term survival is excellent in early-stage and reasonably good in locally advanced stage compared to other solid cancers. The aim of the study was the cross sectional evaluation of the quality of life in survivors completing at least 3 years of follow-up after curative therapy for cervical cancer at a tertiary cancer institute.

Methods: All patients, following primary curative treatment with no evidence of recurrence and completing at least 3 years follow-up, were assessed for QOL using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-30 and its cervical cancer module (Cx24). Read More

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A Case of Yellow Nail Syndrome in Which Intranodal Lymphangiography Contributed to the Diagnosis.

Intern Med 2021 Jun 5. Epub 2021 Jun 5.

Department of Respiratory Medicine, Saitama Medical University Hospital, Japan.

Yellow nail syndrome (YNS) is a rare disease comprising the clinical triad of yellow nail discoloration, pleural effusion, and lower limb lymphedema. We encountered a difficult-to-treat case of YNS in which the diagnosis was finally made based on intranodal lymphangiography. An 84-year-old man was admitted to our hospital with pleural effusion and yellow-green discoloration of the nails, accompanied by onychomycosis and limb lymphedema. Read More

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The transverse musculocutaneous gracilis flap for autologous breast reconstruction: focus on donor site morbidity.

Breast Cancer 2021 Jun 6. Epub 2021 Jun 6.

Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Center, BG Trauma Center Ludwigshafen, Hand and Plastic Surgery, University of Heidelberg, Ludwigshafen, Germany.

Purpose: The transverse musculocutaneous gracilis (TMG) flap is as a valuable alternative in autologous breast reconstruction. The purpose of this study was to evaluate the donor site morbidity and secondary refinement procedures after TMG flap breast reconstruction.

Methods: A retrospective study was conducted, including all patients who received TMG flap breast reconstructions, from January 2012 to August 2019. Read More

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Effect of structured training programme on arm dysfunction, lymphoedema and quality of life after breast cancer surgery.

J Pak Med Assoc 2021 May;71(5):1413-1419

Department of Nursing, Sakarya University, Sakarya, Turkey.

Objective: To evaluate the effect of education given according to daily living activities model on arm dysfunction, lymphoedema and quality of life in patients undergoing breast cancer surgery.

Methods: The randomised controlled study was done at a tertiary hospital and comprised patients undergoing breast cancer surgery who underwent breast cancer surgery from November 2017 to October 2018. After randomisation, the intervention group received education through specifically-designed tools, while the control group received routine care. Read More

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Vascularized Lymph Node Transfer for Surgical Treatments of Upper Versus Lower Extremity Lymphedema.

J Vasc Surg Venous Lymphat Disord 2021 Jun 3. Epub 2021 Jun 3.

Department of Plastic Surgery, Korea University College of Medicine, Seoul, South Korea. Electronic address:

Objective: The purpose of this study was to compare clinical outcomes following vascularized lymph node transfer (VLNT) for the treatment of lymphedema performed on the upper and lower extremities.

Methods: Between April 2015 and January 2020, 71 patients with advanced-stage lymphedema, categorized as International Society of Lymphology late stage 2 or 3, who underwent VLNT in upper and lower extremities were included in this study. Thirty-seven and 34 patients underwent VLNT in upper and lower extremities, respectively. Read More

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Characteristics, clinical presentation and treatment outcomes of venous malformation in the extremities.

J Vasc Surg Venous Lymphat Disord 2021 Jun 3. Epub 2021 Jun 3.

Division of Vascular surgery, Stony Brook medicine, Stony Brook, United States. Electronic address:

Objectives: The clinical presentation of venous malformations (VMs) is variable and not well documented. This study was designed to determine the clinical characteristics and outcomes in association with the type and extent of VM in the extremities.

Methods: Patients diagnosed by ultrasound, CT or MRI were included. Read More

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The effect of omitting axillary dissection and the impact of radiotherapy on patients with breast cancer sentinel node macrometastases: a cohort study following the ACOSOG Z0011 and AMAROS trials.

Breast Cancer Res Treat 2021 Jun 4. Epub 2021 Jun 4.

Bellvitge University Hospital: Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain.

Purpose: To report the outcomes of implementing the ACOSOG Z0011 and AMAROS trials relevant to clinical practice, and to define target groups in whom to avoid or recommend axillary radiotherapy (ART). We also aimed to analyse the reduction in morbidity when axillary lymph node dissection (ALND) was omitted.

Methods: A retrospective cohort study of T1-T2 patients with macrometastases at sentinel lymph node (SLN) who were treated between 2011 and 2020. Read More

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The Effects of Synbiotic Supplementation on Serum Anti-Inflammatory Factors in the Survivors of Breast Cancer with Lymphedema following a Low Calorie Diet: A Randomized, Double-Blind, Clinical Trial.

Nutr Cancer 2021 Jun 4:1-13. Epub 2021 Jun 4.

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

Background And Aim: Breast cancer-related lymphedema (BCRL) is a treatment-related inflammatory complication in breast cancer survivors (BCSs). This study was aimed to evaluate the effect of synbiotic supplementation on serum concentrations of IL-10, TGF-β, VEGF, adiponectin, and edema volume among overweight or obese BCSs with lymphedema following a low-calorie diet (LCD).

Method: In a randomized double-blind, controlled clinical trial, 88 obese and overweight BCSs women were randomized to synbiotic supplement ( = 44) or placebo ( = 44) groups and both groups followed an LCD for 10 weeks. Read More

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The Interrater Reliability of the Scoring of the Lymphatic Architecture and Transport Through Near-InfraRed Fluorescence Lymphatic Imaging in Patients with Breast Cancer-Related Lymphedema.

Lymphat Res Biol 2021 Jun 2. Epub 2021 Jun 2.

Department of Vascular Surgery, Centre for Lymphedema, UZ Leuven-University Hospitals Leuven, Leuven, Belgium.

Of the 1.38 million women who are diagnosed every year with breast cancer worldwide, 21% will develop arm lymphedema. Near-infrared fluorescence lymphatic imaging (NIRFLI) is an effective method for real-time evaluation of the lymphatic system. Read More

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Lymphedema rehabilitation: Provision and practice patterns among service providers: National survey.

Int Wound J 2021 Jun 1. Epub 2021 Jun 1.

University of Missouri, Sinclair School of Nursing, Columbia, Missouri, USA.

Information on the current practices and quantification of lymphedema service may be beneficial to promote and improve the current health care system. Therefore, this study aimed to describe the characteristics of lymphedema practitioners, and lymphedema patients' profiles, and provide a comprehensive picture of lymphedema service provision in Saudi Arabia. A cross-sectional study design used an online survey to gather data. Read More

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The impact of lymphedema on health-related quality of life up to 10 years after breast cancer treatment.

NPJ Breast Cancer 2021 Jun 1;7(1):70. Epub 2021 Jun 1.

Department of Plastic Surgery, Research Unit for Plastic Surgery, Odense University Hospital, Odense, Denmark.

The impact of breast cancer-related lymphedema (BCRL) on long-term quality of life is unknown. The aim of this study was to investigate the impact of BCRL on health-related quality of life (HRQoL) up to 10 years after breast cancer treatment. This regional population-based study enrolled patients treated for breast cancer with axillary lymph node dissection between January 1st 2007 and December 31th 2017. Read More

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Lymphatic Connexins and Pannexins in Health and Disease.

Int J Mol Sci 2021 May 27;22(11). Epub 2021 May 27.

Department of Pathology and Immunology, University of Geneva, CH-1211 Geneva, Switzerland.

This review highlights current knowledge on the expression and function of connexins and pannexins, transmembrane channel proteins that play an important role in intercellular communication, in both the developing and mature lymphatic vasculature. A particular focus is given to the involvement of these proteins in functions of the healthy lymphatic system. We describe their influence on the maintenance of extracellular fluid homeostasis, immune cell trafficking to draining lymph nodes and dietary nutrient absorption by intestinal villi. Read More

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Lower-Limb Lymphedema after Sentinel Lymph Node Biopsy in Cervical Cancer Patients.

Cancers (Basel) 2021 May 13;13(10). Epub 2021 May 13.

Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University and General University Hospital, 12000 Prague, Czech Republic.

Background: To prospectively assess LLL incidence among cervical cancer patients treated by uterine surgery complemented by SLN biopsy, without PLND.

Methods: A prospective study in 150 patients with stage IA1-IB2 cervical cancer treated by uterine surgery with bilateral SLN biopsy. Objective LLL assessments, based on limb volume increase (LVI) between pre- and postoperative measurements, and subjective patient-perceived swelling were conducted in six-month periods over 24-months post-surgery. Read More

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Breast Cancer-Related Lymphedema: Recent Updates on Diagnosis, Severity and Available Treatments.

J Pers Med 2021 May 12;11(5). Epub 2021 May 12.

Division of Plastic and Reconstructive Surgery, Department of Medical and Surgical Sciences, Modena Policlinico Hospital, University of Modena and Reggio Emilia, 41124 Modena, Italy.

Breast cancer-related lymphedema (BCRL) represents a global healthcare issue affecting the emotional and life quality of breast cancer survivors significantly. The clinical presentation is characterized by swelling of the affected upper limb, that may be accompanied by atrophic skin findings, pain and recurrent cellulitis. Cardinal principles of lymphedema management are the use of complex decongestive therapy and patient education. Read More

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Cognitions and physical impairments in relation to upper limb function in women with pain and myofascial dysfunctions in the late stage after breast cancer surgery: an exploratory cross-sectional study.

Disabil Rehabil 2021 Jun 1:1-8. Epub 2021 Jun 1.

Pain in Motion International Research Group, Brussels, Belgium.

Purpose: Upper limb (UL) function is one of the health outcomes that matters the most for women with breast cancer. However, a better understanding of the factors contributing to UL dysfunctions in the late stage after breast cancer surgery is needed. This study explores associations between impairment-related and cognition-related factors and UL function in women with pain and myofascial dysfunctions at the affected UL region in this late stage after breast cancer surgery. Read More

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Necrotizing Fasciitis Occurred in the Lymphedematous leg.

Int J Low Extrem Wounds 2021 May 31:15347346211023030. Epub 2021 May 31.

13622JR Tokyo General Hospital, Tokyo, Japan.

Lymphedema is a chronic edema that sometimes occurs after treatment of gynecologic cancer, and cellulitis often occurs concomitantly with lymphedema. On the other hand, necrotizing fasciitis (NF) is a relatively rare, but life-threatening disease. The symptoms in cellulitis and NF are very similar. Read More

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Standard of care for lipedema in the United States.

Phlebology 2021 May 28:2683555211015887. Epub 2021 May 28.

The US Standard of Care Committee.

Background: Lipedema is a loose connective tissue disease predominantly in women identified by increased nodular and fibrotic adipose tissue on the buttocks, hips and limbs that develops at times of hormone, weight and shape change including puberty, pregnancy, and menopause. Lipedema tissue may be very painful and can severely impair mobility. Non-lipedema obesity, lymphedema, venous disease, and hypermobile joints are comorbidities. Read More

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Ipsilateral Intravenous Catheter Placement in Breast Cancer Surgery Patients.

Anesth Analg 2021 May 26. Epub 2021 May 26.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.

Background: There is a continued perception that intravenous line (IV) placement is contraindicated in the arm ipsilateral to prior breast cancer surgery to avoid breast cancer-related lymphedema (BCRL). The aim of this retrospective study was to determine the risk for development of BCRL in ipsilateral arm IV placement compared to contralateral arm IV placement to prior breast cancer surgery.

Methods: We performed a retrospective review, via our Integrated Clinical Systems and Epic Electronic Heath Record of IV placement for anesthesia and surgery in patients with a prior history of breast cancer surgery with or without axillary lymph node dissection. Read More

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Experience in a rehabilitation center for mastectomized women at the start of the COVID-19 pandemic.

Rev Gaucha Enferm 2021 19;42(spe):e20200331. Epub 2021 May 19.

Universidad de Concepción (UDEC), Facultad de Enfermería, Departamento Fundamentos de Enfermería y Salud Pública. Concepción, Región del Biobío, Chile.

Objective: Describe the experience lived in an interdisciplinary follow-up care center for mastectomized women at a public university in São Paulo during the beginning of the COVID-19 pandemic.

Method: Experience report on the health care provided in the health center for mastectomized women.

Results: The care was provided three times a week by an interdisciplinary health team. Read More

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