13,742 results match your criteria Milroy Disease


Evaluation of a Novel Water-Based Volumetric Device for Measuring Upper Limb Lymphedema: First Experience with Healthy Volunteers.

Lymphat Res Biol 2019 Jan 17. Epub 2019 Jan 17.

Department of Plastic and Reconstructive Surgery, Maastricht University Medical Center +, Maastricht, The Netherlands.

Background: Lymphedema is a chronic, progressive disease consisting of tissue swelling resulting from excessive retention of lymphatic fluid. Measuring upper limb volume is crucial in patients to detect disease progression and to study the effects of treatment. The aim is to assess the validity and reliability of a newly developed system, Peracutus Aqua Meth, for measuring the upper limb volume compared with the gold standard water volumetry device. Read More

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http://dx.doi.org/10.1089/lrb.2018.0037DOI Listing
January 2019

Hormone therapy outcome in lymphedema.

Aging (Albany NY) 2019 Jan 16. Epub 2019 Jan 16.

I2MC, INSERM UMR 1048, CHU-Rangueil, Université de Toulouse, Toulouse, France.

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http://dx.doi.org/10.18632/aging.101772DOI Listing
January 2019

Small Peptide Modulation of Fibroblast Growth Factor Receptor 3-Dependent Postnatal Lymphangiogenesis.

Lymphat Res Biol 2019 Jan 16. Epub 2019 Jan 16.

1 Division of Plastic and Reconstructive Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California.

Background: The fibroblast growth factor receptor (FGFR) family includes transmembrane receptors involved in a wide range of developmental and postdevelopmental biologic processes as well as a wide range of human diseases. In particular, FGFR3 has been implicated in the mechanism by which 9-cis retinoic acid (9-cisRA) induces lymphangiogenesis and improves lymphedema. The purpose of this study was to validate the efficacy of a novel small peptide FGFR3 inhibitor, peptide P3 (VSPPLTLGQLLS), and to elucidate the role of FGFR3 in 9-cisRA-induced lymphangiogenesis using this peptide. Read More

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http://dx.doi.org/10.1089/lrb.2018.0035DOI Listing
January 2019

Reliability, Validity, and Feasibility of Water Displacement Method, Figure-of-Eight Method, and Circumference Measurements in Determination of Ankle and Foot Edema.

Lymphat Res Biol 2019 Jan 16. Epub 2019 Jan 16.

5 Department of Rehabilitation Sciences and Physiotherapy, Ghent University, Ghent, Belgium.

Background: To compare interrater reliability and the time-efficiency for the water displacement method, figure-of-eight method, and circumference measurements of the ankle and foot, and to investigate concurrent validity of the figure-of-eight method and circumference measurements with the water displacement method.

Methods And Results: Thirty patients (21 women and 9 men) with primary or secondary lower limb lymphedema were evaluated twice. The volume of the foot and ankle was measured in three different ways: water displacement with a volumeter, figure-of-eight method, and circumference measurements at the level of the malleoli and metatarsals with a tapeline. Read More

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http://dx.doi.org/10.1089/lrb.2018.0045DOI Listing
January 2019

A prospective multicenter trial on sentinel lymph node biopsy in patients with early-stage cervical cancer (SENTIX).

Int J Gynecol Cancer 2019 Jan;29(1):212-215

Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic.

Objective: Sentinel lymph node (SLN) biopsy has been increasingly used in the management of early-stage cervical cancer. It appears in guidelines as an alternative option to systematic pelvic lymphadenectomy. The evidence about safety is, however, based mostly on retrospective studies, in which SLN was combined with systematic lymphadenectomy. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000010DOI Listing
January 2019

Lymphedema, serious adverse events, and imaging 1 year after comprehensive staging for endometrial cancer: results from the RASHEC trial.

Int J Gynecol Cancer 2019 Jan;29(1):86-93

Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet and Theme Cancer, Karolinska University Hospital, Stockholm, Sweden.

Background And Objectives: In the Robot Assisted Surgery for High Risk Endometrial Cancer (RASHEC) trial, patients with high-risk endometrial cancer were randomly assigned to robot-assisted laparoscopic surgery (RALS) or laparotomy for pelvic and infrarenal para-aortic lymph node dissection. We here report on self-reported lower limb lymphedema (LLL), lymphocyst formation, ascites, and long-term serious adverse events 12 months after surgery.

Patients And Methods: Patients were enrolled between 2013 and 2016, and 96 patients were included in the per protocol analysis, evenly distributed between RALS and laparotomy. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000019DOI Listing
January 2019

Computational investigation of the Laplace law in compression therapy.

J Biomech 2018 Dec 19. Epub 2018 Dec 19.

ZCCE, College of Engineering, Swansea University, United Kingdom. Electronic address:

This study aims to use computational methods for elucidating the effect of limb shape on subgarment and subcutaneous pressures, stresses and strains. A framework was built that generates computational models from 3D arm scans using a depth sensing camera. Finite Element Analysis (FEA) was performed on the scans taken from 23 lymphoedema patients. Read More

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http://dx.doi.org/10.1016/j.jbiomech.2018.12.021DOI Listing
December 2018

Breast cancer treatment-related lymphedema (BCRL): An overview of the literature and updates in microsurgery reconstructions.

Eur J Surg Oncol 2019 Jan 4. Epub 2019 Jan 4.

Department of Plastic and Reconstructive Surgery, National Center for Global Health and Medicine Hospital, Japan. Electronic address:

Breast cancer is the most common cancer in Dharmais hospital. The treatment can give rise to breast cancer treatment-related lymphedema (BCRL) that will cause significant morbidities. Based on author's (BB) patient series in Dharmais hospital, BCRL occurred in 27. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.01.004DOI Listing
January 2019
1 Read

Resistance exercise and breast cancer related lymphedema - a systematic review update.

Disabil Rehabil 2019 Jan 13:1-10. Epub 2019 Jan 13.

a Department of Physical Medicine Rehabilitation and Occupational Medicine , Medical University of Vienna , Vienna , Austria.

Background: Purpose of this systematic review update was analyzing resistance exercise (RE) intervention trials in breast cancer survivors (BCS) regarding their effect on breast cancer-related lymphedema (BCRL) status. Articles published until 31 September 2017 were included.

Methods: A systematic literature search was conducted utilizing PubMed, MEDLINE, and EMBASE databases. Read More

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http://dx.doi.org/10.1080/09638288.2018.1514663DOI Listing
January 2019
1 Read

Changes in high endothelial venules in lymph nodes after vascularized and nonvascularized lymph node transfer in a murine autograft model.

J Surg Oncol 2019 Jan 12. Epub 2019 Jan 12.

Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Background And Objectives: Vascularized lymph node transfer (LNT) is gaining popularity in the treatment of lymphedema. However, it is unclear whether the vascularization of transferred lymph nodes (LNs) contributes to functional improvement. High endothelial venules (HEVs) are specialized vessels that allow lymphocytes to enter LNs. Read More

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http://dx.doi.org/10.1002/jso.25365DOI Listing
January 2019

T helper 2 differentiation is necessary for development of lymphedema.

Transl Res 2018 Dec 21. Epub 2018 Dec 21.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:

T cells infiltrating lymphedematous tissues have a mixed T helper 1 (Th1) and Th2 differentiation profile. Treatment with neutralizing antibodies targeting cytokines that promote Th2 differentiation (interleukin 4 [IL-4] and IL-13) decreases the severity of lymphedema in preclinical models, suggesting that Th2 cells play a key role in the pathology of this disease. However, these previous studies do not address the contribution of Th1 cells and it remains unknown if IL-4 and IL-3 blockade acts primarily on T cells or decreases the pathological changes of lymphedema by other mechanisms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19315244183023
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http://dx.doi.org/10.1016/j.trsl.2018.12.003DOI Listing
December 2018
1 Read

Progressive resistance training to prevent arm lymphedema in the first year after breast cancer surgery: Results of a randomized controlled trial.

Cancer 2019 Jan 11. Epub 2019 Jan 11.

Survivorship Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.

Background: Existing research suggests that progressive resistance training (PRT) after breast cancer (BC) surgery is safe, but the preventive effect on arm lymphedema has yet to be determined.

Methods: Women aged 18 to 75 years who were undergoing BC surgery with axillary lymph node dissection were eligible for the study. Recruited on the day of surgery, participants were allocated to intervention or usual care by computer randomization. Read More

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http://doi.wiley.com/10.1002/cncr.31962
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http://dx.doi.org/10.1002/cncr.31962DOI Listing
January 2019
1 Read

The Long-term Patency of Lymphaticovenular Anastomosis in Breast Cancer-Related Lymphedema.

Ann Plast Surg 2019 Feb;82(2):196-200

From the Department of Plastic and Reconstructive Surgery and.

Background And Objectives: Lymphedema is a condition that can greatly affect patient's quality of life. Promising results have been described with lymphaticovenular anastomosis (LVA) in the treatment of lymphedema. It is currently unknown at what rate anastomoses remain functional after a longer follow-up. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001674DOI Listing
February 2019
2 Reads

Compression therapy in lymphedema: Between past and recent scientific data.

Phlebology 2019 Jan 9:268355518824524. Epub 2019 Jan 9.

2 Eurocenter Venalinfa, San Benedetto del Tronto (AP), Italy.

Aim: To extrapolate and discuss the scientific data on compression in lymphedema treatment, so to review old and innovative concepts about pressure, stiffness and other interplaying factors related to its efficacy and comfort.

Material And Methods: Narrative review based on search in Medline/Google Scholar through key-words related to compression in lymphedema.

Results: Currently available literature lacks relevant details about data on protocol, devices, techniques, interface pressure, stiffness, as well as biases are represented by the different descriptions to present the outcomes. Read More

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http://dx.doi.org/10.1177/0268355518824524DOI Listing
January 2019

[Imaging for treatment planning in lipo-and lymphedema].

Handchir Mikrochir Plast Chir 2018 Dec 8;50(6):386-392. Epub 2019 Jan 8.

Universitätsklinikum Erlangen Plastisch- und Handchirurgische.

Lipoedema is a progressive disease, which predominantly affects women. It is characterised by circumferential growth, with increase in fat tissue of the extremities, and can lead to oedema. In contrast, the lymphoedema is defined by a specific lymphatic drainage disorder and can lead to fibrosis of the surrounding connective tissue. Read More

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http://dx.doi.org/10.1055/a-0739-7911DOI Listing
December 2018
2 Reads

Characterizing Lower Extremity Lymphedema and Lipedema with Cutaneous Ultrasonography and an Objective Computer-Assisted Measurement of Dermal Echogenicity.

Lymphat Res Biol 2019 Jan 7. Epub 2019 Jan 7.

3 Department of Plastic and Reconstructive Surgery, University of Southern California, Los Angeles, California.

Background: Sonographic findings differ in patients with primary lipedema from those with lymphedema. This project was designed to quantify those differences and objectively characterize findings of lipedema and lymphedema in the lower extremity.

Methods And Results: Patients with a clinical diagnosis of ISL stage I-II lipedema or lower extremity lymphedema that received ultrasound evaluation were included in this study. Read More

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http://dx.doi.org/10.1089/lrb.2017.0090DOI Listing
January 2019
1 Read

Comprehensive multimodal surgical treatment of end-stage lower extremity lymphedema with toe management: The combined Charles,' Homan's, and vascularized lymph node transfer (CHAHOVA) procedures.

J Surg Oncol 2019 Jan 6. Epub 2019 Jan 6.

Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung, Taiwan.

Background: End-stage lower extremity lymphedema (LEL) poses a particularly formidable challenge to surgeons as multiple pathological processes are at work. Because single modality treatment is often unsuccessful, we devised a comprehensive multimodal surgical treatment. The aim of this study is to share the technical considerations and examine the clinical outcomes of this combined approach. Read More

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http://dx.doi.org/10.1002/jso.25356DOI Listing
January 2019
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Combined double vascularized lymph node transfers and modified radical reduction with preservation of perforators for advanced stages of lymphedema.

J Surg Oncol 2019 Jan 4. Epub 2019 Jan 4.

Department of Plastic and Reconstructive Surgery, China Medical University, Taichung, Taiwan.

Background: Treatment of advanced lymphedema requires not only restoration of physiological lymph drainage, but also excision of fibrotic tissue and excess skin. The aim of this study is to show how the combination of double vascularized lymph node transfers (VLNTs) and a modified radical reduction with preservation of perforators (RRPP) can accomplish both of these treatment goals.

Methods: Between 2010 and 2016, 16 patients (15 female and one male) with extremity lymphedema underwent a combined double gastroepiploic VLNTs and modified RRPP. Read More

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http://dx.doi.org/10.1002/jso.25360DOI Listing
January 2019
1 Read

Robotic inguinal lymph node dissection for melanoma: a novel approach to a complicated problem.

J Robot Surg 2019 Jan 3. Epub 2019 Jan 3.

Division of Plastic and Reconstructive Surgery, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124, Bari, Italy.

Following the interesting reading of the article "Robotic inguinal lymph node dissection for melanoma: a novel approach to a complicated problem", the authors review the pros and cons of a minimally invasive technique for lymph node dissection, the consequences of complete lymph node dissection and the possible treatments for lymphedema, such as lymph node flap transfer and multiple lymphatic-venous anastomoses. The authors also review the possible benefits of applying the robotic technique to anatomical sites other than the inguinal one. Read More

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http://dx.doi.org/10.1007/s11701-018-00906-xDOI Listing
January 2019

Use of Sentinel Lymph Node Biopsy after Neoadjuvant Chemotherapy in Patients with Axillary Node-Positive Breast Cancer in Diagnosis.

J Breast Cancer 2018 Dec 23;21(4):433-441. Epub 2018 Nov 23.

Division of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: This study aimed to evaluate the effects of sentinel lymph node biopsy (SLNB) on recurrence and survival after neoadjuvant chemotherapy (NAC) in breast cancer patients with cytology-proven axillary node metastasis.

Methods: We selected patients who were diagnosed with invasive breast cancer and axillary lymph node metastasis and were treated with NAC followed by curative surgery between January 2007 and December 2014. We classified patients into three groups: group A, negative sentinel lymph node (SLN) status and no further dissection; group B, negative SLN status with backup axillary lymph node dissection (ALND); and group C, no residual axillary metastasis on pathology with standard ALND. Read More

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http://dx.doi.org/10.4048/jbc.2018.21.e54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310714PMC
December 2018

Breast cancer-related lymphedema in postmastectomy patients receiving adjuvant irradiation: A prospective study.

Indian J Cancer 2018 Apr-Jun;55(2):184-189

Department of Radiotherapy, SMS Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India.

Context: In India, most breast cancer patients present with advanced stage requiring postmastectomy radiotherapy. Lymphedema is a long-term side effect that causes both physical and psychological distresses.

Aims: The present prospective study was carried out to study various factors affecting breast cancer-related lymphedema (BCRL). Read More

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http://dx.doi.org/10.4103/ijc.IJC_570_17DOI Listing
January 2019
1 Read

Small numbers of CD4+ T cells can induce development of lymphedema.

Plast Reconstr Surg 2018 Dec 26. Epub 2018 Dec 26.

Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065.

Background: CD4 T cells have been implicated in the pathology of lymphedema. Interestingly, however, there have been case reports of lymphedema development in patients with low levels of CD4 T cells due to immunosuppression. In this study, we sought to delineate the effect of relative CD4 T cell deficiency on the development of lymphedema in a mouse model. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005322DOI Listing
December 2018
2 Reads

Myiasis-induced sepsis: a rare case report of Wohlfahrtiimonas chitiniclastica and Ignatzschineria indica bacteremia in the continental United States.

Medicine (Baltimore) 2018 Dec;97(52):e13627

Trauma and Acute Care Surgery, Indiana University Health Methodist Hospital, Indianapolis, Indiana.

Rationale: The presentation of sepsis and bacteremia in cutaneous and cavitary myiasis is uncommon. We present a patient, residing in a temperate region of the United States, with myiasis and sepsis from the emerging human pathogens Wohlfahrtiimonas chitiniclastica and Ignatzschineria indica.

Patient Concerns: A 37-year-old male patient with an 8-month history of chronic lymphedema and ulcers of the lower left extremity presented with myiasis of the left foot and leg. Read More

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http://dx.doi.org/10.1097/MD.0000000000013627DOI Listing
December 2018

Podoplanin+ tumor lymphatics are rate limiting for breast cancer metastasis.

PLoS Biol 2018 Dec 28;16(12):e2005907. Epub 2018 Dec 28.

Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

Metastatic dissemination employs both the blood and lymphatic vascular systems. Solid tumors dynamically remodel and generate both vessel types during cancer progression. Lymphatic vessel invasion and cancer cells in the tumor-draining lymph nodes (LNs) are prognostic markers for breast cancer metastasis and patient outcome, and tumor-induced lymphangiogenesis likely influences metastasis. Read More

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http://dx.plos.org/10.1371/journal.pbio.2005907
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http://dx.doi.org/10.1371/journal.pbio.2005907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310240PMC
December 2018
4 Reads

Baseline Lymphatic Dysfunction Amplifies the Negative Effects of Lymphatic Injury.

Plast Reconstr Surg 2019 Jan;143(1):77e-87e

New York, N.Y. From the Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center.

Background: Genetic mutations and obesity increase the risk of secondary lymphedema, suggesting that impaired lymphatic function before surgical injury may contribute to disease pathophysiology. Previous studies show that obesity not only decreases lymphatic function, but also markedly increases pathologic changes, such as swelling, fibroadipose deposition, and inflammation. However, although these reports provide circumstantial evidence supporting the hypothesis that baseline lymphatic defects amplify the effect of lymphatic injury, the mechanisms regulating this association remain unknown. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311716PMC
January 2019
5 Reads

Implementing a community vector collection strategy using xenomonitoring for the endgame of lymphatic filariasis elimination.

Parasit Vectors 2018 Dec 27;11(1):672. Epub 2018 Dec 27.

Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.

Background: The global strategy for elimination of lymphatic filariasis is by annual mass drug administration (MDA). Effective implementation of this strategy in endemic areas reduces Wuchereria bancrofti in the blood of infected individuals to very low levels. This minimises the rate at which vectors successfully pick microfilariae from infected blood, hence requiring large mosquito numbers to detect infections. Read More

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http://dx.doi.org/10.1186/s13071-018-3260-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307201PMC
December 2018

Whole Exome Sequencing Reveals the Major Genetic Contributors to Non-Syndromic Tetralogy of Fallot.

Circ Res 2018 Nov 28. Epub 2018 Nov 28.

Division of Cardiovascular Sciences, University of Manchester, UNITED KINGDOM.

Rationale: Familial recurrence studies provide strong evidence for a genetic component to the predisposition to sporadic, non-syndromic Tetralogy of Fallot (TOF), the most common cyanotic congenital heart disease (CHD) phenotype. Rare genetic variants have been identified as important contributors to the risk of CHD, but relatively small numbers of TOF cases have been studied to date.

Objective: We used whole exome sequencing (WES) to assess the prevalence of unique, deleterious variants in the largest cohort of non-syndromic TOF patients reported to date. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313250DOI Listing
November 2018
2 Reads

Tackling the diversity of breast cancer related lymphedema: Perspectives on diagnosis, risk assessment, and clinical management.

Breast 2018 Dec 17;44:15-23. Epub 2018 Dec 17.

Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy. Electronic address:

Breast cancer related lymphedema (BCRL) develops as a consequence of surgical treatment and/or radiation therapy in a significant number of breast cancer patients. The etiology of this condition is multifactorial and has not yet been completely elucidated. Risk factors include high body mass index, radical surgical procedures (i. Read More

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http://dx.doi.org/10.1016/j.breast.2018.12.009DOI Listing
December 2018
1 Read

Hamartomas and malformations of the liver.

Semin Diagn Pathol 2018 Nov 17. Epub 2018 Nov 17.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States. Electronic address:

Hamartomas and malformations of the liver are rare and can lead to diagnostic challenges. Most present as mass lesions that can mimic true neoplasms of the liver on imaging and sometimes on histology, one example being focal nodular hyperplasia. The primary cell type in the hamartomas and malformations can be biliary, vascular, or hepatic. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.11.005DOI Listing
November 2018
1 Read

Letter to the Editor regarding "Lymphedema in patients with hidradenitis suppurativa: a systematic review of published literature".

Int J Dermatol 2018 Dec 21. Epub 2018 Dec 21.

Dermatology Department, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

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http://doi.wiley.com/10.1111/ijd.14342
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http://dx.doi.org/10.1111/ijd.14342DOI Listing
December 2018
3 Reads

Impairment of Lymphatic Endothelial Barrier Function by X-ray Irradiation.

Int J Radiat Biol 2018 Dec 20:1-25. Epub 2018 Dec 20.

a Department of Medical Physiology , Texas A&M University College of Medicine , Temple , TX , USA.

Purpose: Although the microvascular system is a significant target for radiation-induced effects, the lymphatic response to radiation has not been extensively investigated. This is one of the first investigations characterizing the lymphatic endothelial response to ionizing radiation.

Materials And Methods: Rat mesenteric lymphatic endothelial cells (RMLECs) were exposed to X-ray doses of 0, 0. Read More

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http://dx.doi.org/10.1080/09553002.2019.1562253DOI Listing
December 2018

Interrater and Intrarater Reliability of Subcutaneous Echogenicity Grade and Subcutaneous Echo-Free Space Grade in Breast Cancer-Related Lymphedema.

Lymphat Res Biol 2018 Dec 20. Epub 2018 Dec 20.

Department of Physical Medicine and Rehabilitation, Marmara University School of Medicine, İstanbul, Turkey.

Background: Subcutaneous echogenicity grade (SEG) and subcutaneous echo-free space (SEFS) grade allow semiquantitation of nonspecific subcutaneous tissue inflammation and fluid accumulation in breast cancer-related lymphedema. However, inter- and intrarater reliability of SEG and SEFS is yet to be reported. The objective of this study is to assess inter-rater and intrarater reliability of SEG and SEFS in patients with breast cancer-related lymphedema. Read More

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http://dx.doi.org/10.1089/lrb.2018.0053DOI Listing
December 2018
1 Read

[Current status of chronic filariasis in Jiangsu Province].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2018 Nov;30(5):563-566

Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China.

Objective: To understand the current status of chronic filariasis patients in Jiangsu Province so as to provide basic data for following-up care for them.

Methods: The patients were followed up one by one according to history archives between June and July, 2018, and the clue investigation was also conducted. The base data of the patients was collected through a face-to-face questionnaire survey and analyzed. Read More

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http://dx.doi.org/10.16250/j.32.1374.2018215DOI Listing
November 2018
4 Reads

Lipedema-An update.

Authors:
Uwe Wollina

Dermatol Ther 2018 Dec 18:e12805. Epub 2018 Dec 18.

Department of Dermatology and Allergology, Academic Teaching Hospital Dresden, Dresden, Germany.

Lipedema is a chronic disabilitating disease affecting the subcutaneous adipose tissue of the extremities in females during or after puberty. The disease is characterized by bilateral swelling of legs and/or arms, bruising, and pain. In contrast to lymphedema, the most distal parts remain unaffected. Read More

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http://dx.doi.org/10.1111/dth.12805DOI Listing
December 2018
1 Read

Novel mutation in as a cause of recurrent hydrops fetalis from Hennekam lymphangiectasia-lymphedema syndrome-1.

Clin Case Rep 2018 Dec 24;6(12):2358-2363. Epub 2018 Oct 24.

Division of Maternal-Fetal Medicine Department of Obstetrics, Gynecology, and Reproductive Sciences University of California San Diego La Jolla California.

Whole exome sequencing (WES) was used to determine the etiology of recurrent hydrops fetalis in this case of Hennekam lymphangiectasia-lymphedema syndrome-1. WES is a useful approach for diagnosing rare single-gene conditions with nonspecific phenotypes and should be considered early in the diagnostic process of investigating fetal abnormalities. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.1804
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http://dx.doi.org/10.1002/ccr3.1804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293140PMC
December 2018
3 Reads

Lymphatic Tissue Engineering and Regeneration.

J Biol Eng 2018 17;12:32. Epub 2018 Dec 17.

1Department of Aerospace and Mechanical Engineering, Bioengineering Graduate Program, University of Notre Dame, Notre Dame, IN 46556 USA.

The lymphatic system is a major circulatory system within the body, responsible for the transport of interstitial fluid, waste products, immune cells, and proteins. Compared to other physiological systems, the molecular mechanisms and underlying disease pathology largely remain to be understood which has hindered advancements in therapeutic options for lymphatic disorders. Dysfunction of the lymphatic system is associated with a wide range of disease phenotypes and has also been speculated as a route to rescue healthy phenotypes in areas including cardiovascular disease, metabolic syndrome, and neurological conditions. Read More

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https://jbioleng.biomedcentral.com/articles/10.1186/s13036-0
Publisher Site
http://dx.doi.org/10.1186/s13036-018-0122-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296077PMC
December 2018
5 Reads

The Relationship Between Clinical and Indocyanine Green Staging in Lymphedema.

Lymphat Res Biol 2018 Dec 18. Epub 2018 Dec 18.

1 Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, Illinois.

Background: Multiple staging systems for classifying the severity of lymphedema exist. The International Society of Lymphology (ISL) stage is considered standard for clinical reporting, but the relationship between clinical and functional/imaging stage remains poorly defined.

Materials And Methods: We reviewed the prospectively collected data of all patients who underwent physiologic lymphedema surgery for a 3-year period by the senior author. Read More

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http://dx.doi.org/10.1089/lrb.2018.0014DOI Listing
December 2018

Optimizing Patient Positioning to Reduce Variation in the Measurement of Breast Cancer-Related Lymphedema.

Lymphat Res Biol 2018 Dec 18. Epub 2018 Dec 18.

4 Department of Radiation Oncology, and The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Prospective lymphedema screening is recommended for breast cancer patients. We observed interoperator variation in perometer-acquired arm volume measurements (P-AVMs) due to patient instability during measurements. We hypothesized that improved positioning during perometry would reduce P-AVM variability. Read More

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http://dx.doi.org/10.1089/lrb.2018.0018DOI Listing
December 2018

Development and Evaluation of a New In Vivo Volume Measuring System in Mouse Tail Lymphedema Model.

Lymphat Res Biol 2018 Dec 18. Epub 2018 Dec 18.

1 Biorobotics Laboratory, Department of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea.

Backgrounds: Secondary lymphedema is a common complication of parasitization and breast or gynecologic cancer therapy; however, options for the treatment of lymphedema are ineffective and limited. A mouse tail model is one of the most successful animal models for a lymphatic study. Lymphedema of the mouse tail is characterized by increases in the volume of the extremity caused by accumulation of tissue fluid, proliferation of fibroblasts and adipocytes, and excessive production of collagen. Read More

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http://dx.doi.org/10.1089/lrb.2018.0019DOI Listing
December 2018

Complete Decongestive Therapy Is an Option for the Treatment of Rosacea Lymphedema (Morbihan Disease): Two Cases.

Phys Ther 2018 Dec 18. Epub 2018 Dec 18.

Department of Dermatology, Ankara University.

Background And Purpose: Morbihan disease, also known as rosacea lymphedema, is a rare persistent form of lymphedema that is associated with the disease of rosacea. Even though acne rosacea responds well to standard medical treatment, the lymphedema component of the disease is resistant to both medical and surgical therapy. Complete decongestive therapy (CDT) may be considered as a conservative alternative option for treatment of rosacea lymphedema. Read More

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https://academic.oup.com/ptj/advance-article/doi/10.1093/ptj
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http://dx.doi.org/10.1093/ptj/pzy155DOI Listing
December 2018
3 Reads

Mechanical Dilation Using Nylon Monofilament Aids Multisite Lymphaticovenous Anastomosis Through Improving the Quality of Anastomosis.

Ann Plast Surg 2019 Feb;82(2):201-206

Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Lymphaticovenous anastomosis (LVA) is now a common treatment for lymphedema. It is important to create as many bypasses as possible to maximize the efficacy of LVA. We have developed a method whereby nylon monofilaments are placed inside the vessel lumen to act as dilators. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001681DOI Listing
February 2019
4 Reads

Functional loss in daily activity in ovarian cancer patients undergoing chemotherapy.

Arch Gynecol Obstet 2018 Dec 17. Epub 2018 Dec 17.

Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Purpose: Cancer survivors frequently experience cancer or treatment-related symptoms and functional morbidities that can be addressed through rehabilitation services, but these symptoms often go unnoticed and seldom managed. This study seeks to investigate the undetected patient symptoms and functional loss related to the activities of daily living (ADLs) in ovarian cancer patients during chemotherapy and to identify the influence of chemotherapy on such loss.

Methods: Ovarian cancer patients undergoing chemotherapy were identified from June to August 2016, who were treated at the department of Gynecology and Obstetrics of two tertiary hospitals. Read More

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http://link.springer.com/10.1007/s00404-018-4996-x
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http://dx.doi.org/10.1007/s00404-018-4996-xDOI Listing
December 2018
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Lymphedema following breast cancer: The importance of surgical methods and obesity.

Front Womens Health 2018 Jun 31;3(2). Epub 2018 May 31.

Department of Surgery, College of Medicine, University of Iowa, Iowa City, IA, USA.

Background: Breast cancer-related arm lymphedema is a serious complication that can adversely affect quality of life. Identifying risk factors that contribute to the development of lymphedema is vital for identifying avenues for prevention. The aim of this study was to examine the association between the development of arm lymphedema and both treatment and personal (e. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293280PMC
http://dx.doi.org/10.15761/FWH.1000144DOI Listing
June 2018
3 Reads

A novel autosomal dominant mutation in SOX18 resulting in a fatal case of hypotrichosis-lymphedema-telangiectasia syndrome.

Am J Med Genet A 2018 Dec 14;176(12):2824-2828. Epub 2018 Dec 14.

Department of Pediatrics, University of California, San Diego and Rady Children's Hospital, San Diego, California.

Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS) is a rare disorder caused by autosomal recessive and autosomal dominant mutations in SOX18. This gene encodes a transcription factor involved in the regulation and development of the human vasculature, lymphatic, and integumentary systems. Individuals with HLTS develop varying degrees of hypotrichosis, lymphedema, and telangiectasias. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ajmg.a.40532
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http://dx.doi.org/10.1002/ajmg.a.40532DOI Listing
December 2018
3 Reads

Secondary lymphedema after high ligation of the great saphenous vein surgery: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13379

Department of Vascular Surgery, Yuhuangding Hospital, Qingdao University.

A 56-year-old male patient with secondary lymphedema in a single lower extremity presented to our hospital.He received high ligation of great saphenous vein 3 years ago. Severe infection was observed in affected limb on postoperative day 10, and rapidly progressive pain and erythema spreading to inguinal region. Read More

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http://dx.doi.org/10.1097/MD.0000000000013379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310514PMC
December 2018
6 Reads

Early Detection and Treatment of Subclinical Lymphedema in Patients with Breast Cancer.

Lymphat Res Biol 2018 Dec 13. Epub 2018 Dec 13.

Department of Physical Medicine and Rehabilitation, Yıldırım Beyazıt Dışkapı Research and Training Hospital, University of Health Science , Ankara, Turkey .

Background: Early identification and treatment of subclinical lymphedema may prevent development of advanced stages and its related complications. We aimed to detect subclinical lymphedema and to evaluate the effects of early treatment program on the development of clinical lymphedema, upper extremity functions, and quality of life in patients with subclinical lymphedema.

Methods And Results: Twenty-five women who were diagnosed having subclinical lymphedema were enrolled in the study. Read More

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http://dx.doi.org/10.1089/lrb.2018.0033DOI Listing
December 2018
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Work experiences of Australian cancer survivors with lymphoedema: A qualitative study.

Health Soc Care Community 2018 Dec 7. Epub 2018 Dec 7.

Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Australian Lymphedema Education, Research & Treatment, Macquarie University, Sydney, NSW, Australia.

Our qualitative study addresses a significant gap in the scholarship on return-to-work after cancer by examining the impact of secondary lymphoedema on individuals in paid employment. We undertook an Interpretive Phenomenological Analysis of interviews with 14 cancer survivors (13 women) with secondary lymphoedema in Sydney, Australia. Our interviewees were engaged in paid employment during and after their lymphoedema diagnosis. Read More

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http://dx.doi.org/10.1111/hsc.12698DOI Listing
December 2018
5 Reads

GATA2 deficiency and human hematopoietic development modeled using induced pluripotent stem cells.

Blood Adv 2018 Dec;2(23):3553-3565

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, MD.

GATA2 deficiency is an inherited or sporadic genetic disorder characterized by distinct cellular deficiency, bone marrow failure, various infections, lymphedema, pulmonary alveolar proteinosis, and predisposition to myeloid malignancies resulting from heterozygous loss-of-function mutations in the gene. How heterozygous mutations affect human hematopoietic development or cause characteristic cellular deficiency and eventual hypoplastic myelodysplastic syndrome or leukemia is not fully understood. We used induced pluripotent stem cells (iPSCs) to study hematopoietic development in the setting of GATA2 deficiency. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018017137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290105PMC
December 2018
2 Reads

Present status of sentinel lymph node biopsy in cervical cancer.

Rep Pract Oncol Radiother 2018 Nov-Dec;23(6):495-502. Epub 2018 May 9.

Gynecological Oncology Unit, Barcelona Clinic Hospital, 170 Villaroel St, Barcelona 08036, Spain.

Cervical cancer is the fourth most common cancer in women, and seventh overall. This disease represents a medical, economic and social burden. In early FIGO stage patients (IA, IB1 and IIA1), nodal involvement is the most important prognostic factor. Read More

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http://dx.doi.org/10.1016/j.rpor.2018.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277279PMC
May 2018
1 Read