14,969 results match your criteria Milroy Disease


Managing Lymphedema in Fracture Care: Current Concepts and Treatment Principles.

J Am Acad Orthop Surg 2020 Jul 1. Epub 2020 Jul 1.

From the Department of Orthopedics, Community Memorial Health System (Dr. Thomas), Department of Orthopedics, Ventura County Medical Center (Dr. Benson), Ventura, CA, and the Department of Orthopedics and Sports Medicine, Houston Methodist Hospital, Houston, TX (Dr. Le).

Lymphatic flow plays a notable role in the regulation of bone formation and remodeling. Chronic accumulation of the lymph fluid within tissues may lead to issues with proper bone healing after fractures, emphasizing the importance of proper management of lymphedema after trauma. Many associated risk factors place patients at risk for lymphedema, including previous surgery with nodal dissection, radiation therapy, infection, malignancy, family history of congenital lymphedema, and trauma. Read More

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http://dx.doi.org/10.5435/JAAOS-D-19-00722DOI Listing

Increased levels of VEGF-C and macrophage infiltration in lipedema patients without changes in lymphatic vascular morphology.

Sci Rep 2020 Jul 2;10(1):10947. Epub 2020 Jul 2.

Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.

Lipedema is a chronic adipose tissue disorder characterized by the disproportional subcutaneous deposition of fat and is commonly misdiagnosed as lymphedema or obesity. The molecular determinants of the lipedema remain largely unknown and only speculations exist regarding the lymphatic system involvement. The aim of the present study is to characterize the lymphatic vascular involvement in established lipedema. Read More

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http://dx.doi.org/10.1038/s41598-020-67987-3DOI Listing

Implementing a prospective surveillance and early intervention model of care for breast cancer-related lymphedema into clinical practice: application of the RE-AIM framework.

Support Care Cancer 2020 Jun 29. Epub 2020 Jun 29.

Vanderbilt University School of Nursing, Nashville, TN, USA.

Purpose: Chronic lymphedema following breast cancer (BC) affects individuals physically, functionally, psychologically, and financially. Despite national guidelines and evidence-based research supporting a prospective surveillance and early intervention model of care (PSM), bridging the gap between research and clinical practice has been difficult.

Method: As part of an international randomized controlled trial (RCT), Australian women with BC from four hospitals were recruited, monitored for lymphedema at regular intervals over a 3-year period, and were provided a compression garment if intervention was triggered. Read More

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http://dx.doi.org/10.1007/s00520-020-05597-5DOI Listing

Effects of 12 weeks of water aerobics on body composition in those affected by breast cancer.

Support Care Cancer 2020 Jul 1. Epub 2020 Jul 1.

Exercising Nutritionally, LLC, Lisle, IL, USA.

Exercise may prevent changes in body composition and provide an effective means of improving the side effects of treatment without causing lymphedema.

Purpose: Test the effectiveness of a 12-week water aerobics program on body composition and lymphedema risk in breast cancer survivors.

Methods: Body composition analysis was completed at weeks 0, 6, and 12 weeks. Read More

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http://dx.doi.org/10.1007/s00520-020-05596-6DOI Listing

Magnetic resonance imaging and bioimpedance evaluation of lymphatic abnormalities in patients with breast cancer treatment-related lymphedema.

Breast Cancer Res Treat 2020 Jun 29. Epub 2020 Jun 29.

Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.

Purpose: Breast cancer treatment-related lymphedema (BCRL) evaluation is frequently performed using portable measures of limb volume and bioimpedance asymmetry. Here quantitative magnetic resonance imaging (MRI) is applied to evaluate deep and superficial tissue impairment, in both surgical and contralateral quadrants, to test the hypothesis that BCRL impairment is frequently bilateral and extends beyond regions commonly evaluated with portable external devices.

Methods: 3-T MRI was applied to investigate BCRL topographical impairment. Read More

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http://dx.doi.org/10.1007/s10549-020-05765-5DOI Listing

A 61-year-old woman with chronic leg lymphedema managed with complete decongestive therapy.

CMAJ 2020 Jun;192(26):E708-E712

Alta Vista Chiropractic & Massage Clinic (Bondalevich), Ottawa, Ont.; Vodder Schools International (Bondalevich), North Vancouver, BC; Department of Family Medicine (de Laplante), University of Ottawa, Ottawa, Ont.

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http://dx.doi.org/10.1503/cmaj.190227DOI Listing

Prevalence and incidence of cancer related lymphedema in low and middle-income countries: a systematic review and meta-analysis.

BMC Cancer 2020 Jun 29;20(1):604. Epub 2020 Jun 29.

Improving Palliative, Aged and Chronic Care through Clinical Research and Translation (IMPACCT), Faculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia.

Background: Little is known about the prevalence and incidence in low and middle-income countries (LMICs) of secondary lymphedema due to cancer. The purpose of the study is to estimate the prevalence and incidence in LMICs of secondary lymphedema related to cancer and/or its treatment(s) and identify risk factors.

Method: A systematic review and meta-analysis was conducted. Read More

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http://dx.doi.org/10.1186/s12885-020-07079-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325022PMC

Dysfunction of dermal initial lymphatics of the arm and upper body quadrant causes congenital arm lymphedema.

J Vasc Surg Venous Lymphat Disord 2020 Jun 26. Epub 2020 Jun 26.

Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine.

Objectives: To explore the pathology underlying primary lymphedema.

Methods: Twenty-seven patients with unilateral congenital arm lymphedema who visited our clinic from 1 January 2014 to 30 May 2019 were enrolled. The patients' clinical signs, indocyanine green (ICG) lymphography, skin tissue immunohistochemical (IHC) staining, and whole-exome sequencing (WES) of tissue and blood were evaluated. Read More

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http://dx.doi.org/10.1016/j.jvsv.2020.06.009DOI Listing

Does the Sentinel Lymph Node Sampling Alone Improve Quality of Life in Early Cervical Cancer Management?

Front Surg 2020 12;7:31. Epub 2020 Jun 12.

Service de chirurgie et cancérologie gynécologique et mammaire, Institut Curie, Paris, France.

In this subanalysis of the prospective randomized multicenter SENTICOL 2 study, we compared the quality of life (QoL), in two arms, in association with lower-limb consequences in women with early stage cervical cancer undergoing randomized sentinel lymph node (SLN) sampling alone or SLN sampling and full pelvic lymphadenectomy. 206 patients with an early stage cervical cancer and a negative SLN, were randomized. Every patient had a SLN detection based on a combination of radio-isotope (Nanocis®) and blue dye (Bleu Patenté®) injections. Read More

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http://dx.doi.org/10.3389/fsurg.2020.00031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303263PMC

Grand Rounds: Multimodal surgical management of severe scrotal lymphedema and buried penis.

Urology 2020 Jun 25. Epub 2020 Jun 25.

Harvard Medical School, Boston, Mass; Division of Plastic Surgery, Brigham & Women's Hospital, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.urology.2020.06.016DOI Listing

Investigation on the role of biallelic variants in VEGF-C found in a patient affected by Milroy-like lymphedema.

Mol Genet Genomic Med 2020 Jun 26:e1389. Epub 2020 Jun 26.

Department of Surgery, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), San Raffaele Scientific Institute, Milan, Italy.

Background: Milroy-like disease is the diagnostic definition used for patients with phenotypes that resemble classic Milroy disease (MD) but are negative to genetic testing for FLT4. In this study, we aimed at performing a genetic characterization and biochemical analysis of VEGF-C variations found in a female proband born with congenital edema consistent with Milroy-like disease.

Methods: The proband underwent next-generation sequencing-based genetic testing for a panel of genes associated with known forms of hereditary lymphedema. Read More

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http://dx.doi.org/10.1002/mgg3.1389DOI Listing

Ultra-High frequency ultrasound imaging of lymphatic channels correlates with their histological features: A step forward in lymphatic surgery.

J Plast Reconstr Aesthet Surg 2020 May 25. Epub 2020 May 25.

Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, UOC Chirurgia Plastica, Università Cattolica del "Sacro Cuore" - Fondazione Policlinico Universitario A. Gemelli IRCCS - Largo A. Gemelli 8, 00168 Rome, Italy.

Background: Indocyanine green (ICG) lymphography gained widespread acceptance as a gold standard in lymphatic surgery, although this imaging modality has several limitations. Ultrasound is progressively emerging as a powerful tool in LVA preoperative planning, as it expands the available knowledge for both lymphatic channels and recipient venules. The purpose of this study is to evaluate the accuracy of ultrahigh frequency ultrasound (UHFUS) in detecting the lymphatic vessels and in evaluating their degeneration status, including wall and lumen characteristics, compared with direct histology observation. Read More

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http://dx.doi.org/10.1016/j.bjps.2020.05.053DOI Listing

Interventions for Breast Cancer-Related Lymphedema: Clinical Practice Guideline From the Academy of Oncologic Physical Therapy of APTA.

Phys Ther 2020 Jun 26. Epub 2020 Jun 26.

K. Ryans, PT, DPT, Doctor of Physical Therapy Program, Mercy College, Dobbs Ferry, New York. Dr Ryans is a board-certified clinical specialist in oncologic physical therapy and a certified lymphedema therapist-Lymphology Association of North America.

A work group from the American Physical Therapy Association (APTA) Academy of Oncologic Physical Therapy developed a clinical practice guideline to aid clinicians in identifying interventions for people with breast cancer-related lymphedema, targeting volume reduction, beginning at breast cancer diagnosis and continuing through cancer treatments and survivorship. Following a systematic review of published studies and a structured appraisal process, recommendations were developed to guide physical therapists and other health care clinicians in their intervention selection. Overall, clinical practice recommendations were formulated based on the evidence for each intervention and were assigned a grade based on the strength of the evidence. Read More

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http://dx.doi.org/10.1093/ptj/pzaa087DOI Listing

Editorial on "Simultaneous Ipsilateral Vascularized Lymph Node Transplantation and Contralateral Lymphovenous Anastomosis in Bilateral Different-Severities Extremity Lymphedema".

Ann Surg Oncol 2020 Jun 25. Epub 2020 Jun 25.

Department of Plastic Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1245/s10434-020-08721-1DOI Listing

Labial mucosa grafting for lid margin, anterior lamellar, and posterior lamellar correction in recurrent cicatricial entropion.

Orbit 2020 Jun 25:1-5. Epub 2020 Jun 25.

Ophthalmic Plastic Surgery Services, LJ Eye Institute , Ambala, India.

Purpose: To report a novel modified technique for severe recurrent cicatricial entropion correction based on anterior lamellar recession (ALR) and grafting.

Methods: Six eyelids of five patients (9-48 years; three females) with severe cicatricial entropion (three upper and three lower eyelids) had surgical correction using ALR and labial mucosal grafting for spacing the ciliary margin away from the lid margin and reconstruction of the lid margin and posterior lamella. The modified technique included using mucous membrane as a single unit for anterior lamella, lid margin, and posterior lamella reconstruction employing a different suturing technique. Read More

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http://dx.doi.org/10.1080/01676830.2020.1782439DOI Listing

Clinical Benefits of Supervised Home Care of the Morbidity Management and Disability Prevention Under National Filariasis Elimination Programme.

Lymphat Res Biol 2020 Jun 23. Epub 2020 Jun 23.

Division of Epidemiology and Biostatistics, National Institute of Epidemiology, ICMR, TNHB, Chennai, India.

Mass drug administration and morbidity management and disability prevention (MMDP) though considered as two pillars of global program for elimination of filariasis, implementation of MMDP was disregarded in several endemic countries. Limb hygiene is the main component of MMDP and to address its overall clinical benefits, a community-based study was undertaken in three sets of populations. After obtaining written informed consent, clinical, quality of life (QoL) assessments were carried out and lymphedema volume was measured for three groups of lymphedema patients at intake, at 6, and 12 months follow-up. Read More

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http://dx.doi.org/10.1089/lrb.2019.0058DOI Listing

Theory and Practice of Compression Therapy for Treating and Preventing Venous Ulcers.

Actas Dermosifiliogr 2020 Jun 20. Epub 2020 Jun 20.

Jefe de Servicio de Dermatología. Hospital Universitario Infanta Leonor, Madrid, Spain.

Compression therapy is the basis for treating the cause of venous ulcers and preventing recurrence. Various systems are currently available for applying compression, and adapting them to patients' needs can improve adherence to treatment. Understanding the principles that underlie compression therapy is essential for success. Read More

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http://dx.doi.org/10.1016/j.ad.2020.03.007DOI Listing

The impact of lower body compression garment on left ventricular rotational mechanics in patients with lipedema-Insights from the three-dimensional speckle tracking echocardiographic MAGYAR-Path Study.

Clin Obes 2020 Jun 23:e12380. Epub 2020 Jun 23.

Department of Dermatology and Allergology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary.

Lipedema is a lymphedema-masquerading symmetrical, bilateral and disproportional obesity. Its conservative maintenance treatment comprises the use of flat-knitted compression pantyhoses. Lipedema is known to be associated with left ventricular morphological and functional alterations. Read More

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http://dx.doi.org/10.1111/cob.12380DOI Listing

Non-contrast MR Lymphography of lipedema of the lower extremities.

Magn Reson Imaging 2020 Jun 17;71:115-124. Epub 2020 Jun 17.

Radiology Department, Fatebenefratelli Hospital, ASST Fatebenefratelli Sacco, Milano, Piazza Principessa Clotilde 3, 20121 Milano, Italy.

Aim: To assess imaging findings and characteristics of the lymphatic system in patients affected by lipedema and lipolymphedema of the lower extremities on Non-Contrast MR Lymphography (NCMRL).

Materials And Methods: 44 lower extremities in 11 consecutive female patients affected by lipedema, and 11 patients with lipolymphedema were examined by NCMRL. MR imaging was performed on 1. Read More

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http://dx.doi.org/10.1016/j.mri.2020.06.010DOI Listing

Cutaneous Pathological Changes as Quantifiable Endpoints in Human Lymphedema.

Lymphat Res Biol 2020 Jun;18(3):211

Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1089/lrb.2020.29088.srDOI Listing

Chronic adverse effects after an axillary lymphadenectomy in breast cancer patients after administering weaker and stronger postoperative analgesia: results of a prospective double-blind randomized study.

Breast Cancer Res Treat 2020 Aug 18;182(3):655-663. Epub 2020 Jun 18.

Department of Anesthesiology, Institute of Oncology, Zaloska 2, 1000, Ljubljana, Slovenia.

Purpose: The aim of this study was to compare the rate of chronic adverse effects after a weaker and stronger postoperative analgesia.

Methods: A prospective double-blind randomized study included 117 breast cancer patients receiving tramadol for pain relief for 4 weeks after an axillary lymphadenectomy from 2015 to 2018. Patients with a larger dose received 75/650 mg of tramadol with paracetamol every 8 h and a group with a lower dose received 37. Read More

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http://dx.doi.org/10.1007/s10549-020-05713-3DOI Listing

Simultaneous Ipsilateral Vascularized Lymph Node Transplantation and Contralateral Lymphovenous Anastomosis in Bilateral Extremity Lymphedema with Different Severities.

Ann Surg Oncol 2020 Jun 18. Epub 2020 Jun 18.

Plastic and Reconstructive Surgery, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy.

Background: Extremity lymphedema can occur bilaterally with different severities on each side. The aim of this study is to investigate the treatment outcomes of such patients with bilateral extremity lymphedema of different severities.

Patients And Methods: Between 2013 and 2017, patients with bilateral extremity lymphedema of different severities according to the Taiwan Lymphoscintigraphy Staging (TLS) system were retrospectively reviewed. Read More

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http://dx.doi.org/10.1245/s10434-020-08720-2DOI Listing

A systematic review of the impact of contemporary treatment modalities for cervical cancer on women's self-reported health-related quality of life.

Support Care Cancer 2020 Jun 18. Epub 2020 Jun 18.

The University of Sydney, Faculty of Science, School of Psychology, Quality of Life Office, Sydney, Australia.

Purpose: Given the high survival rate of cervical cancer patients, understanding women's health-related quality of life (HRQL) during and after treatment is of major clinical importance. We conducted a systematic review to synthesize all available evidence about the effects of each contemporary treatment modality for cervical cancer on all dimensions of women's HRQL, including symptoms, functioning, and global HRQL.

Methods: We searched four electronic databases from January 2000 to September 2019, cross-referenced and searched by author name for studies of patients treated for cervical cancer that reported patient-reported outcomes (PROs) before treatment and with at least one post-treatment measurement. Read More

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http://dx.doi.org/10.1007/s00520-020-05554-2DOI Listing

Sequencing of RNA in single cells reveals a distinct transcriptome signature of hematopoiesis in GATA2 deficiency.

Blood Adv 2020 Jun;4(12):2656-2670

Hematology Branch, National Heart, Lung, and Blood Institute.

Constitutional GATA2 deficiency caused by heterozygous germline GATA2 mutations has a broad spectrum of clinical phenotypes, including systemic infections, lymphedema, cytopenias, and myeloid neoplasms. Genotype-phenotype correlation is not well understood mechanistically in GATA2 deficiency. We performed whole transcriptome sequencing of single hematopoietic stem and progenitor cells from 8 patients, who had pathogenic GATA2 mutations and myelodysplasia. Read More

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http://dx.doi.org/10.1182/bloodadvances.2019001352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322959PMC

Comprehensive Decongestive Therapy as a Treatment for Secondary Lymphedema of the Lower Extremity and Quality of Life of Women After Gynecological Cancer Surgery.

Med Sci Monit 2020 Jun 17;26:e924071. Epub 2020 Jun 17.

Department of Physiotherapy, Faculty of Health Care, University of Prešov, Prešov, Slovakia.

BACKGROUND Lymphedema is a clinical manifestation of lymphatic system failure, caused by an imbalance between the transport capacity of the lymphatic system and the volume of the produced lymph. Lymphedema is complication and significantly worsens quality of life (QoL). MATERIAL AND METHODS There were 50 patients diagnosed with secondary lymphedema of the lower extremities after gynecological cancer followed by radiotherapy included in this study. Read More

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http://dx.doi.org/10.12659/MSM.924071DOI Listing

Secondary Angiosarcoma With C-MYC Amplification Following Prophylactic Bilateral Mastectomy and Autologous Breast Reconstruction: Report of a Case and Review of the Literature.

Int J Surg Pathol 2020 Jun 18:1066896920930100. Epub 2020 Jun 18.

UT Southwestern Medical Center, Dallas, TX, USA.

In this article, we report a very rare case of secondary angiosarcoma in a young woman with no prior history of breast cancer who had bilateral prophylactic mastectomies with autologous reconstruction due to a strong family history of breast cancer and gene variant of uncertain significance. The surgery was complicated by recurrent fat necrosis requiring several excisions and additional reconstruction followed by the development of localized lymphedema and subsequent angiosarcoma in the reconstructed breast 10 years later. The angiosarcoma was high grade with prominent epithelioid features associated with abundant tumor-infiltrating lymphocytes. Read More

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http://dx.doi.org/10.1177/1066896920930100DOI Listing

A Case of Congenital Lymphedema Complicated by Chronic Chylous Effusions and Recurrent Pericardial Effusion Requiring Pericardial Window.

Cureus 2020 May 16;12(5):e8160. Epub 2020 May 16.

Pulmonary Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, USA.

We are presenting a case of primary lymphedema (PL) complicated with a repeated need for thoracentesis and pericardiocentesis. Our patient is a 24-year-old male with primary lymphedema that is manifested in the left hand and right lower limb. The patient presented to the emergency department (ED) for recurrent right lower lobe cellulitis that had failed repeated attempts with outpatient antibiotic therapy. Read More

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http://dx.doi.org/10.7759/cureus.8160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294872PMC

Sentinel lymph node biopsy alone in the management of early cervical carcinoma.

Int J Gynecol Cancer 2020 Jun 16. Epub 2020 Jun 16.

Department of Mathematics and Applied Computation, University of Leicester, Leicester, Leicestershire, UK.

Objective: Sentinel lymph node (SLN) biopsy aims to assess lymph node status with reduced surgical morbidity. The aim of the study was to determine the accuracy and safety of SLN biopsy in the management of early cervical carcinoma using a double technique (technetium-99m (Tc-99m) nanocolloid and methylene blue dye injection).

Methods: This was a 10-year study from January 2009 to January 2019 that recruited 103 consecutive women undergoing surgery for early cervical carcinoma, FIGO 2009 stage IA1 (grade 3, and grade 2 with lymphovascular space invasion) to IB1 (<2 cm), at the West Kent Gynaecological Oncology Centre, Maidstone, UK. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001082DOI Listing

Clinical evaluation of tibiocalcaneal arthrodesis with retrograde intramedullary nail fixation in diabetic patients.

Acta Orthop Traumatol Turc 2020 May;54(3):255-261

Department of Orthopedic Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy.

Objective: The aim of this study was to evaluate clinical and functional outcomes in diabetic patients undergoing tibiocalcaneal arthrodesis using a retrograde nail.

Methods: A total of 12 diabetic patients [8 men and 4 women; mean age at intervention: 56.8 years (range: 27-76 years)] who underwent tibiocalcaneal arthrodesis by a retrograde nail were enrolled in this study. Read More

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http://dx.doi.org/10.5152/j.aott.2020.03.334DOI Listing

Relationship between perimetric increase and fluoroscopic pattern type in secondary upper limb lymphedema observed by Indocyanine green lymphography.

Medicine (Baltimore) 2020 Jun;99(24):e20432

Department of Physiotherapy, University of Seville, Spain.

To ascertain the relationship between the perimetric differences obtained between the limbs and the type of fluoroscopic pattern observed by Indocyanine green (ICG) lymphography in patients with upper limb lymphedema.A correlational descriptive study was carried out in 19 patients with upper limb lymphedema secondary to breast cancer. The perimetric increase was recorded in 11 anatomical regions after ICG injection, fluoroscopic patterns were identified using an infrared camera. Read More

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http://dx.doi.org/10.1097/MD.0000000000020432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302654PMC

Psychometric Validation of the Chinese Version of the Lymphedema Functioning, Disability, and Health Questionnaire for Upper Limb Lymphedema in Patients With Breast Cancer-Related Lymphedema.

Cancer Nurs 2020 Jun 12. Epub 2020 Jun 12.

Author Affiliations: Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China (Mss Zhao, Wu, Zhou, Li and Chen), Longgang District Central Hospital of Shenzhen, Shenzhen, Guangdong, PR China (Ms Tao) and Department of Rehabilitation Sciences, KU Leuven-University of Leuven, ResearchGroup for Rehabilitation in Internal Disorders, Leuven, Belgium (Ms De Vrieze).

Background: Breast cancer-related lymphedema (BCRL) has a notable impact on patients' quality of life. However, no instrument is available to assess the problems in functioning due to BCRL in China.

Objective: The aims of this study were to translate and validate a Chinese version of the Lymphedema Functioning, Disability, and Health Questionnaire for Upper Limb Lymphedema (Lymph-ICF-UL). Read More

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http://dx.doi.org/10.1097/NCC.0000000000000848DOI Listing

A quasi-randomized clinical trial: virtual reality versus proprioceptive neuromuscular facilitation for postmastectomy lymphedema.

J Egypt Natl Canc Inst 2020 Jun 15;32(1):29. Epub 2020 Jun 15.

Faculty of Physical Therapy, Cairo University, Giza, Egypt.

Background: Postmastectomy lymphedema can be considered the main cause of upper extremity functional impairment in patients with breast cancer. Fatigue, pain, and limited range of motion are common symptoms. If left untreated, lymphedema causes cellulitis, which can lead to gangrene in rare cases. Read More

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http://dx.doi.org/10.1186/s43046-020-00041-5DOI Listing

Comprehensive Overview of Available Donor Sites for Vascularized Lymph Node Transfer.

Plast Reconstr Surg Glob Open 2020 Mar 27;8(3):e2675. Epub 2020 Mar 27.

Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex.

The field of lymphedema surgery has grown tremendously in recent years. In particular, the diversity of available donor sites for vascularized lymph node transfer has increased, and new donor sites are emerging. Researchers have explored a number of different donor sites, and their reports have demonstrated promising results with each site. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253262PMC

Evolution in Surgical Management of Breast Cancer-related Lymphedema: The MD Anderson Cancer Center Experience.

Plast Reconstr Surg Glob Open 2020 Mar 27;8(3):e2674. Epub 2020 Mar 27.

Department of Plastic Surgery, University of Texas MD Anderson Cancer Center, Houston, Tex.

Lymphedema is a lifelong, debilitating condition that plagues a large portion of patients who have undergone multimodality therapy for breast cancer. With the increasing experience in supermicrosurgical treatment of lymphedema, reconstructive surgeons have made a tremendous impact in improving the quality of life of patients suffering from breast cancer related lymphedema.

Methods: Historical review of our evolution in treatment and management of breast cancer related lymphedema and implementation of our new algorithm. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253265PMC

Intra-abdominal Lymph Nodes: A Privileged Donor Site for Vascularized Lymph Node Transfer.

Plast Reconstr Surg Glob Open 2020 Mar 27;8(3):e2673. Epub 2020 Mar 27.

Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex.

A variety of donor options for vascularized lymph node transfer for the surgical treatment of lymphedema have been described. Intra-abdominal harvest sites including the gastroepiploic nodes within the omental flap and the mesenteric node flap are distinguished from their extra-abdominal counterparts by the absent risk of iatrogenic donor site lymphedema and discrete scar location, as well as the ability to harvest up to 3 vascularized nodal packets from 1 donor site. However, there are also potential morbidities including hernia and intra-abdominal visceral injuries. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253245PMC

Treatment of Upper Extremity Lymphedema following Chemotherapy and Radiation for Head and Neck Cancer.

Plast Reconstr Surg Glob Open 2020 Mar 27;8(3):e2672. Epub 2020 Mar 27.

Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex.

In the industrialized world, the most common cause of secondary lymphedema is iatrogenic. The inciting event is generally a combination of lymph node resection, chemotherapy, and radiation therapy. Although a regional nodal dissection is often the primary risk factor, lymphedema can also result from sentinel node dissections, or as in the case presented without any surgical resection. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253291PMC

Controversies in Surgical Management of Lymphedema.

Plast Reconstr Surg Glob Open 2020 Mar 27;8(3):e2671. Epub 2020 Mar 27.

Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex.

Surgical treatment of lymphedema has expanded in recent years. Lymphovenous bypass and vascularized lymph node transfer are both modern techniques to address the physiologic dysfunction associated with secondary lymphedema. While efficacy of both techniques has been demonstrated in numerous studies, there are several questions that remain. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253258PMC

Building a Multidisciplinary Comprehensive Academic Lymphedema Program.

Plast Reconstr Surg Glob Open 2020 Mar 20;8(3):e2670. Epub 2020 Mar 20.

Division of Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex.

Lymphedema is a debilitating clinical condition predominantly affecting survivors of cancer. It adversely affects patients' quality of life and results in substantial cost burdens to both patients and the healthcare system. Specialist lymphedema care is optimally provided within integrated clinical programs that align the necessary specialties to provide patient-focused, multidisciplinary, structured, and coordinated care. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253282PMC

Combining vascularized lymph node transfer with autologous breast reconstruction: A Surveillance, Epidemiology and End Results (SEER) Database cost-utility analysis.

J Plast Reconstr Aesthet Surg 2020 May 21. Epub 2020 May 21.

Division of Plastic and Reconstructive Surgery, Dalhousie University, 5850/5980 University Avenue, PO Box 9700, Halifax, Nova Scotia B3K 6R8, Canada.

Background: The cost effectiveness of combining vascularized lymph node transfer (VLNT) with autologous breast reconstruction has not been established. Herein we describe the use of Markov modeling to evaluate the cost utility of VLNT with delayed autologous breast reconstruction for patients with breast cancer related lymphedema (BCRL).

Methods: We conducted a cost effectiveness analysis using a Markov model with microsimulation. Read More

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http://dx.doi.org/10.1016/j.bjps.2020.05.027DOI Listing

Genetics of Skin Disease in Horses.

Vet Clin North Am Equine Pract 2020 Jun 10. Epub 2020 Jun 10.

Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Almas Allé 8, Uppsala 75007, Sweden. Electronic address:

Equine skin diseases are common, causing increased costs and reduced welfare of affected horses.Genetic testing, if available, can complement early detection, disease diagnosis, and clinical treatment and offers horse breeders the possibility to rule out carrier status. The mechanisms of complex disease can be investigated by using the latest state-of-the-art genomic technologies. Read More

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http://dx.doi.org/10.1016/j.cveq.2020.03.010DOI Listing

Picturing health: podoconiosis-stepping out of neglect.

Lancet 2019 10 16;394(10208):1499-1512. Epub 2019 Sep 16.

Centre for Global Health Research, Brighton & Sussex Medical School, Brighton, UK; School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia.

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http://dx.doi.org/10.1016/S0140-6736(19)32129-4DOI Listing
October 2019

Semiquantitative scoring system for lymphedema using Non-contrast Magnetic Resonance Lymphography (NMRL): Statistical issues on reproducibility to avoid misinterpretation.

Authors:
Siamak Sabour

Magn Reson Imaging 2020 Jun 10;71:103-104. Epub 2020 Jun 10.

Department of Clinical Epidemiology, School of Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Safety Promotions and Injury Prevention Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. Electronic address:

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http://dx.doi.org/10.1016/j.mri.2020.06.007DOI Listing

Ultrasound Vibroelastography for Evaluation of Secondary Extremity Lymphedema: A Clinical Pilot Study.

Ann Plast Surg 2020 Jul;85(S1 Suppl 1):S92-S96

From the Division of Plastic and Reconstructive Surgery.

Background: Lymphedema treatment is an ongoing challenge. It impacts quality of life due to pain, loss of range of motion of the extremity, and repeated episodes of cellulitis. Different modalities have been used to evaluate lymphedema; some are more error-prone and some are more invasive. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002448DOI Listing
July 2020
1.458 Impact Factor

Gastroepiploic Lymph Node Flap Harvest for Patients With Lymphedema: Minimally Invasive Versus Open Approach.

Ann Plast Surg 2020 Jul;85(S1 Suppl 1):S87-S91

Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung City, Taiwan.

Background: Vascularized gastroepiploic lymph node flaps have become a popular option to treat patients with extremity lymphedema. Overall, 2 surgical approaches to harvest this flap have been described: laparoscopic and open. In this study, we analyzed complications, harvesting time, and patient satisfaction scores, comparing these 2 techniques. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002460DOI Listing
July 2020
1.458 Impact Factor

Presentation and Management of Klippel-Trenaunay Syndrome: A Review of Available Data.

Cureus 2020 May 8;12(5):e8023. Epub 2020 May 8.

Internal Medicine, Dow University of Health Sciences, Karachi, PAK.

Klippel-Trenaunay Syndrome (KTS) is a rare and sporadic congenital disorder, characterized by the classical triad of port-wine stains, varicosities along with bone and soft tissue hypertrophy. Symptoms of Klippel-Trenaunay Syndrome include pain, swelling, lymphedema, bleeding, superficial thrombophlebitis, and deep vein thrombosis. The etiology remains indistinct and has been attributed to both genetic and environmental factors. Read More

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http://dx.doi.org/10.7759/cureus.8023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282379PMC

Platelet factor 4 is a biomarker for lymphatic-promoted disorders.

JCI Insight 2020 Jun 11. Epub 2020 Jun 11.

Center for Vascular and Developmental Biology, Feinberg Cardiovascular and , Northwestern University, Chicago, United States of America.

Genetic or acquired defects of the lymphatic vasculature often result in disfiguring, disabling and, occasionally, life-threatening clinical consequences. Advanced forms of lymphedema are readily diagnosed clinically, but more subtle presentations often require invasive imaging or other technologies for a conclusive diagnosis. On the other hand, lipedema, a chronic lymphatic microvascular disease with pathological accumulation of subcutaneous adipose tissue is often misdiagnosed as obesity or lymphedema; currently there are no biomarkers or imaging criteria available for a conclusive diagnosis. Read More

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http://dx.doi.org/10.1172/jci.insight.135109DOI Listing

Advances and current concepts in reconstructive surgery for breast cancer.

Semin Oncol 2020 May 24. Epub 2020 May 24.

Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH, United States of America. Electronic address:

In this article, we report on recent advancements in reconstructive care of the breast cancer patient. New developments in sensate breast reconstruction to help address the problem of numbness after mastectomy have emerged and show promise. Methods to restore lymphatic physiologic flow after axillary lymphadenectomy using supermicrosurgical techniques have begun to show benefit by reducing the short-term incidence of breast cancer related lymphedema (BRCL). Read More

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http://dx.doi.org/10.1053/j.seminoncol.2020.05.007DOI Listing

Watershed of posterior thigh lymph flows: Posterior midline vs. mid-lateral injection for posterior thigh indocyanine green lymphography.

Injury 2020 May 23. Epub 2020 May 23.

Department of Plastic and Reconstructive Surgery, National Center for Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku; 162-8655; Tokyo; Japan.

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http://dx.doi.org/10.1016/j.injury.2020.05.036DOI Listing

Microsurgical lymphatic vascular grafting and secondary liposuction: Results of combination treatment in secondary lymphedema.

Lymphology 2020 ;53(1):38-47

Division of Hand, Plastic and Aesthetic Surgery, University Hospital, LMU Munich, Germany.

Surgical treatment of lymphedema with liposuction typically requires subsequent compression therapy. Here we describe an approach where secondary arm lymphedemas are initially treated by autologous lymphatic grafting to bypass the axilla and restore lymphatic flow. In the presence of excess adipose tissue, liposuction is then performed in a second procedure. Read More

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January 2020