16,853 results match your criteria Milroy Disease

Commentary: Gastroepiploic vascularized lymph node transfer for extremities' lymphedema: Is two better than one? A retrospective case-control study.

J Plast Reconstr Aesthet Surg 2022 Jun 17. Epub 2022 Jun 17.

Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, 1400 Pressler St., Unit 1488, Houston 77030, TX, USA. Electronic address:

View Article and Full-Text PDF

Current Mechanistic Understandings of Lymphedema and Lipedema: Tales of Fluid, Fat, and Fibrosis.

Int J Mol Sci 2022 Jun 14;23(12). Epub 2022 Jun 14.

Department of Medical Physiology, Texas A & M University College of Medicine, Bryan, TX 77807, USA.

Lymphedema and lipedema are complex diseases. While the external presentation of swollen legs in lower-extremity lymphedema and lipedema appear similar, current mechanistic understandings of these diseases indicate unique aspects of their underlying pathophysiology. They share certain clinical features, such as fluid (edema), fat (adipose expansion), and fibrosis (extracellular matrix remodeling). Read More

View Article and Full-Text PDF

Case study: night compression use in a patient with Milroy's disease.

Br J Nurs 2022 Jun;31(12):S34-S41

Nurse Consultant and Senior Lecturer, Allied Health Research Unit, University of Central Lancashire, Preston, and Northern Lymphology Limited, Slaidburn, Lancashire.

Aim: Lymphoedema is associated with dysfunctional lymphatics, tissue fibrosis and inflammatory changes in the skin and local tissue. Ensuring compression supports tissue health is crucial to managing lymphoedema. Providing patients with safe compression which enhances their tissue health is paramount when supporting their 24-hour self-management regimens. Read More

View Article and Full-Text PDF

Feasibility of machine-delivered sequential massage for the management of lymphedema in the head and neck cancer survivor.

Laryngoscope Investig Otolaryngol 2022 Jun 9;7(3):774-778. Epub 2022 May 9.

Louisiana State University Shreveport Louisiana USA.

Background: Lymphedema after treatment for head and neck cancer negatively impacts the quality of life and can produce neck tissue stiffness, dysphagia, pain, and swelling. One form of treatment for lymphedema is machine-delivered sequential lymphedema massage, which is home based and self administered. This study was undertaken to determine economic and system access to home-based lymphedema therapy and to measure patient-reported outcomes among those able to access therapy. Read More

View Article and Full-Text PDF

Psychological distress in breast cancer patients during oncological inpatient rehabilitation: incidence, triggering factors and correlation with treatment-induced side effects.

Arch Gynecol Obstet 2022 Jun 22. Epub 2022 Jun 22.

Institut Für Rehabilitationsforschung Und Survivorship (IREFOS), 88175, Scheidegg, Germany.

As a result of the cancer diagnosis and the mostly multimodal, stressful therapy, psychological distress is a common symptom in breast cancer patients. As part of this prospective study, 1400 patients who were admitted to the hospital for oncological rehabilitation were screened for distress and somatic, therapy-induced secondary disorders. Mean distress in the screened population was 5. Read More

View Article and Full-Text PDF

Single-cell RNA sequencing of subcutaneous adipose tissues identifies therapeutic targets for cancer-associated lymphedema.

Cell Discov 2022 Jun 21;8(1):58. Epub 2022 Jun 21.

Division of Plastic Surgery, Peking Union Medical College Hospital, Beijing, China.

Cancer-associated lymphedema frequently occurs following lymph node resection for cancer treatment. However, we still lack effective targeted medical therapies for the treatment or prevention of this complication. An in-depth elucidation of the cellular alterations in subcutaneous adipose tissues of lymphedema is essential for medical development. Read More

View Article and Full-Text PDF

Impact of retrograde anastomosis during supermicrosurgical lymphaticovenous anastomosis for cancer-related lower limb lymphedema: A retrospective cohort propensity-score-matched outcome analysis.

Int J Surg 2022 Jun 17;104:106720. Epub 2022 Jun 17.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: In addition to antegrade anastomosis, retrograde anastomosis has been thought to offer further improvements after lymphaticovenous anastomosis (LVA) by bypassing the retrograde lymphatic flow. However, this concept has yet to be validated. The aim of this study was to determine the impacts on outcomes of performing both retrograde and antegrade anastomosis, as compared to antegrade-only anastomosis for treating lower limb lymphedema. Read More

View Article and Full-Text PDF

Targeting Lymphatics for Nanoparticle Drug Delivery.

Front Pharmacol 2022 3;13:887402. Epub 2022 Jun 3.

Department of Bioengineering, University of Maryland College Park, College Park, MD, United States.

The lymphatics transport material from peripheral tissues to lymph nodes, where immune responses are formed, before being transported into systemic circulation. With key roles in transport and fluid homeostasis, lymphatic dysregulation is linked to diseases, including lymphedema. Fluid within the interstitium passes into initial lymphatic vessels where a valve system prevents fluid backflow. Read More

View Article and Full-Text PDF

Evaluation of Relative Abundance of Lymphedema after Reverse Axillary Mapping in Patients with Breast Cancer.

Adv Biomed Res 2022 29;11:36. Epub 2022 Apr 29.

Department of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: The axillary reverse mapping (ARM) technique identifies and preserves arm nodes during sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND). Here, we aimed to investigate the prevalence of lymphedema following ARM.

Materials And Methods: This is a clinical trial that was performed in 2019-2020 in Isfahan on patients with breast cancer in the early stages. Read More

View Article and Full-Text PDF

A Case Report on Breast Cancer-Related Lymphedema in Adulthood.

Cureus 2022 May 16;14(5):e25042. Epub 2022 May 16.

Physiotherapy, Fortis Super Specialty Hospital, Delhi, IND.

Breast cancer is a common occurrence in women, and it is also associated with lymphedema. In this case, the patient reported breast cancer-related lymphedema after a radical mastectomy with axillary lymph node dissection in the left breast; after her treatment, she experienced this condition for three months. Following the assessment, it was determined that the lymphedema was in stage 2 as a result of the delay. Read More

View Article and Full-Text PDF

DIEP flap breast reconstruction combined with vascularized lymph node transfer for patients with breast cancer-related lymphedema.

Eur J Surg Oncol 2022 May 20. Epub 2022 May 20.

Department of Plastic and Reconstructive Surgery, Radboud University Medical Center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands.

Introduction: Lymphedema is a condition which heavily impacts patients QoL. For patients who desire autologous breast reconstruction, lymph nodes can be included in the Deep Inferior Epigastric Artery (DIEP) flap combining vascularized lymph node transfer and autologous breast reconstruction.

Material And Methods: Patients who received autologous breast reconstruction with a DIEP flap in combination with vascularized lymph nodes were included in this study. Read More

View Article and Full-Text PDF

Genetic landscape of FOXC2 mutations in lymphedema-distichiasis syndrome: Different mechanism of pathogenicity for mutations in different domains.

Exp Eye Res 2022 Jun 15:109136. Epub 2022 Jun 15.

Health Management Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Sichuan Provincial Key Laboratory for Human Disease Gene Study and Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China. Electronic address:

Lymphedema-dissociated syndrome (LDS), of which the pathogenesis is not fully understood, afflicts many patients. In this study, we investigated the effect of FOXC2 gene loss-of-function on the development of LDS disease.Two Han Chinese families with LDS were recruited in this study, pathogenic mutations were identified by Sanger sequencing. Read More

View Article and Full-Text PDF

Retrograde Lymph Flow in the Lymphatic Vessels in Limb Lymphedema.

J Vasc Surg Venous Lymphat Disord 2022 Jun 14. Epub 2022 Jun 14.

Australian Lymphoedema Education, Research and Treatment (ALERT), Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.

Objective: Retrograde movement of lymph due to damaged and/or incompetent valves in the lymphatic vessels has been considered a pathological feature of lymphedema. This study aimed to determine the prevalence of retrograde lymph flow and the characteristics of patients with this condition using indocyanine green (ICG) lymphography.

Methods: An audit of 679 patients with upper or lower limb swelling who underwent ICG lymphography was undertaken over a 4-year period. Read More

View Article and Full-Text PDF

Lymphatic function and anatomy in early stages of lipedema.

Obesity (Silver Spring) 2022 Jun 15. Epub 2022 Jun 15.

Center for Molecular Imaging, Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

Objective: Lipedema is an inflammatory subcutaneous adipose tissue disease that develops in women and may progress to lipolymphedema, a condition similar to lymphedema, in which lymphatic dysfunction results in irresolvable edema. Because it has been shown that dilated lymphatic vessels, impaired pumping, and dermal backflow are associated with presymptomatic, cancer-acquired lymphedema, this study sought to understand whether these abnormal lymphatic characteristics also characterize early stages of lipedema prior to lipolymphedema development.

Methods: In a pilot study of 20 individuals with Stage I or II lipedema who had not progressed to lipolymphedema, lymphatic vessel anatomy and function in upper and lower extremities were assessed by near-infrared fluorescence lymphatic imaging and compared with that of a control population of similar age and BMI. Read More

View Article and Full-Text PDF

May-Thurner Syndrome and Lymphedema Reconstruction.

Plast Reconstr Surg Glob Open 2022 Jun 10;10(6):e4377. Epub 2022 Jun 10.

Oakland University William Beaumont School of Medicine, Rochester, Mich.

May-Thurner syndrome (MTS) is an anatomical variant that results in compression of the left common iliac vein by the right common iliac artery. Although often asymptomatic, lower extremity swelling/edema, deep venous thrombosis, post-thrombotic syndrome, and eventual lymphedema (due to long-standing venous obstruction) can develop. The clinical management of patients presenting for lymphedema surgery with concomitant or undiagnosed MTS is not well described. Read More

View Article and Full-Text PDF

Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion.

Circ Res 2022 Jun 14:101161CIRCRESAHA121320565. Epub 2022 Jun 14.

Department of Surgery (D.C., E.P., R.P.Y., M.N.C., I.-T.C., J.C., J.Y., L.Z., J.-E.I.Y., J.S.Y., B.N., S.L., Y.J.S., W.J., Y.-K.H.).

Background: Mutations in cause human lymphatic malformations. We have previously uncovered an Orai1-mediated mechanotransduction pathway that triggers lymphatic sprouting through Notch downregulation in response to fluid flow. However, the identity of its upstream mechanosensor remains unknown. Read More

View Article and Full-Text PDF

[Shock wave therapy in oncology: in vitro, in vivo, rehabilitation].

Vopr Kurortol Fizioter Lech Fiz Kult 2022 ;99(3):58-65

Moscow Scientific and Practical Center for Medical Rehabilitation, Restorative and Sports Medicine of the Department of Health of the City of Moscow, Moscow, Russia.

Extracorporeal shock wave therapy (ESWT) is a relatively new branch of physiotherapy.

Purpose Of The Study: Conduct an analytical review of the available literature data on the use of ESWT in oncology.

Material And Methods: A review was conducted, including data from electronic databases: Scopus, Web of Science, MedLine, World Health Organization, The Cochrane Central Register of Controlled Trials, ScienceDirect, US National Library of Medicine National Institutes of Health, PubMed, Google Scholar, elibrary, CyberLeninka, disserCat. Read More

View Article and Full-Text PDF

Integrated transmission assessment surveys (iTAS) of lymphatic filariasis and onchocerciasis in Cross River, Taraba and Yobe States, Nigeria.

Parasit Vectors 2022 Jun 13;15(1):201. Epub 2022 Jun 13.

Federal Ministry of Health, Abuja, Nigeria.

Background: Integrated transmission assessment surveys (iTAS) have been recommended for evaluation of the transmission of both lymphatic filariasis (LF) and onchocerciasis as the prevalence of both diseases moves toward their respective elimination targets in Nigeria. Therefore, we conducted an iTAS between May and December 2017 in five local government areas (LGAs), also known as implementation units (IUs), in states of Cross River, Taraba and Yobe in Nigeria.

Methods: The TAS comprised two phases: the Pre-iTAS and the iTAS itself. Read More

View Article and Full-Text PDF

Statistical methods for linking geostatistical maps and transmission models: Application to lymphatic filariasis in East Africa.

Spat Spatiotemporal Epidemiol 2022 Jun 21;41:100391. Epub 2020 Nov 21.

Department of Statistics, University of Warwick, Coventry, UK; Zeeman Institute, University of Warwick, Coventry, UK. Electronic address:

Infectious diseases remain one of the major causes of human mortality and suffering. Mathematical models have been established as an important tool for capturing the features that drive the spread of the disease, predicting the progression of an epidemic and hence guiding the development of strategies to control it. Another important area of epidemiological interest is the development of geostatistical methods for the analysis of data from spatially referenced prevalence surveys. Read More

View Article and Full-Text PDF

Hypofractionation with simultaneous integrated boost after breast-conserving surgery: Long term results of two phase-II trials.

Breast 2022 Aug 2;64:136-142. Epub 2022 Jun 2.

Klinik für Strahlentherapie, Universitätsklinikum Schleswig-Holstein und Christian-Albrechts-Universität zu Kiel, Germany. Electronic address:

Purpose: To analyze long-term results of two multicenter prospective single-arm trials (ARO-2010-01 and ARO-2013-04) investigating adjuvant hypofractionated radiotherapy (HF) with simultaneous integrated boost (SIB) after breast-conserving surgery (BCS).

Methods: Eligible patients had histopathologically confirmed unifocal breast cancer planned for whole breast irradiation plus boost radiotherapy to the tumor bed. In both studies, a total dose of 40 Gy was applied to the whole breast and of 48 Gy to the tumor bed in 16 fractions of 2. Read More

View Article and Full-Text PDF

Relationship of Adjuvant Radiation and the Lymphedema Index: A Valuable Trend to Follow Subclinical Lymphedema in Patients After Immediate Lymphatic Reconstruction.

Ann Plast Surg 2022 06;88(5 Suppl 5):S512-S516

From the Department of Plastic and Reconstructive Surgery, University of South Florida, Morsani College of Medicine.

Background: Immediate lymphaticovenular bypass (immediate lymphatic reconstruction [ILR]) at the time of axillary lymph node dissection has emerged as a preventative paradigm to decrease the incidence of breast cancer-related lymphedema in high-risk patients. These patients are often treated with adjuvant therapies, including radiation. Bioimpedance spectroscopy is a validated tool for trending breast cancer-related lymphedema and identifying subclinical disease. Read More

View Article and Full-Text PDF

Avoiding post mastectomy lateral "Dog Ears" by an L incision and lipoaspiration: The Paris Breast Center technique.

Eur J Surg Oncol 2022 May 25. Epub 2022 May 25.

Oncoplastic Breast Surgeon at "L'Institut Du Sein-The Paris Breast Centre", Paris, France.

Background: Lateral dog ear after mastectomy in overweight or large breasted patients is a source for patient discomfort and is aesthetically unpleasing. Although many different techniques have been proposed, none of them have emerged as standard. In 2012, the authors published their mastectomy technique based on an inverted L-scar incision and closure with a lateral skin flap advanced supero-medially onto the chest wall. Read More

View Article and Full-Text PDF

Regional Nodal Management in the Setting of Up-Front Surgery.

Semin Radiat Oncol 2022 Jul;32(3):221-227

Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.

Historically, axillary lymph node dissection was considered necessary for regional control of breast cancer. Moreover, nodal status was the major determinant of the need for chemotherapy. The increased use of systemic therapy coupled with expanding indications for nodal irradiation has led to interest in optimizing patient outcomes by leveraging the local control benefits of radiotherapy and systemic therapy to decrease the extent of surgery. Read More

View Article and Full-Text PDF

Hypoxia-inducible factors: roles in cardiovascular disease progression, prevention, and treatment.

Gregg L Semenza

Cardiovasc Res 2022 Jun 10. Epub 2022 Jun 10.

Armstrong Oxygen Biology Research Center, Vascular Program, Institute for Cell Engineering; and Departments of Genetic Medicine, Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Hypoxia-inducible factors (HIF)-1 and HIF-2 are master regulators of oxygen homeostasis that regulate the expression of thousands of genes in order to match O2 supply and demand. A large body of experimental data links HIF activity to protection against multiple disorders affecting the cardiovascular system: ischemic cardiovascular disease (including coronary artery disease and peripheral artery disease), through collateral blood vessel formation and preconditioning phenomena; emphysema; lymphedema; and lung transplant rejection. In these disorders, strategies to increase the expression of one or both HIFs may be of therapeutic utility. Read More

View Article and Full-Text PDF

Does Venipuncture Increase Lymphedema by Triggering Inflammation or Infection? An Experimental Rabbit Ear Lymphedema Model Study.

Lymphat Res Biol 2022 Jun 10. Epub 2022 Jun 10.

Department of Medical Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey.

Recent guidelines recommend avoiding venipuncture to prevent lymphedema for breast cancer patients. This study investigated whether single or multiple sterile venipuncture procedures develop a systemic inflammation or infection and increase lymphedema in the rabbit ear lymphedema model. Eighteen New Zealand white female rabbits were included. Read More

View Article and Full-Text PDF

What Should We Focus on When Managing Breast Cancer-Related Lymphedema to Improve Quality of Life?

Lymphat Res Biol 2022 Jun 10. Epub 2022 Jun 10.

Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Jongno-Gu, Seoul, Korea.

Breast cancer-related lymphedema (BCRL) is correlated with poor quality of life (QOL). The effects of the management of lymphedema on QOL remain controversial. We analyzed the changes in QOL and identified factors associated with its improvement to improve the care of patients with BCRL. Read More

View Article and Full-Text PDF

Clinical Significance of Serum Collagen Type IV and Procollagen Type III N-Peptide Levels in Diagnosis and Differential Diagnosis of Lymphedema.

Qian Meng Man Zhang

Lymphat Res Biol 2022 Jun 10. Epub 2022 Jun 10.

Clinical Laboratory Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Lymphatic endothelial cells production or modification were closely related to the extracellular matrix (ECM) molecules. The serum hyaluronic acid (HA), laminin (LN), procollagen type III N-peptide (PIIINP), and collagen type IV (CGIV) levels were researched to explore the clinical significance of serum ECM proteins in the diagnosis and differentiation of lymphedema. Fifty-five patients were enrolled. Read More

View Article and Full-Text PDF

Lymphatic Phenotype of Noonan Syndrome: Innovative Diagnosis and Possible Implications for Therapy.

J Clin Med 2022 May 31;11(11). Epub 2022 May 31.

Department of Pediatrics, Radboudumc Amalia Children's Hospital, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.

Dysregulation of the Ras/Mitogen-activated protein kinase (MAPK) signaling pathway is suggested to play a pivotal role in the development of the lymphatic system in patients with Noonan Syndrome (NS). Pathogenic gene variants in the Ras/MAPK pathway can therefore lead to various lymphatic diseases such as lymphedema, chylo-thorax and protein losing enteropathy. Diagnosis and treatment of the lymphatic phenotype in patients with NS remain difficult due to the variability of clinical presentation, severity and, probably, underlying unknown pathophysiologic mechanism. Read More

View Article and Full-Text PDF

Lymphaticovenous Anastomosis for Treating Secondary Lower Limb Lymphedema in Older Patients-A Retrospective Cohort Study.

J Clin Med 2022 May 30;11(11). Epub 2022 May 30.

College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.

Despite an increased incidence of secondary lower limb lymphedema (LLL) and severity of comorbidities with age, the impact of age on the effectiveness of lymphaticovenous anastomosis (LVA) in the older patients remains unclear.

Methods: This retrospective cohort study enrolled older patients (age > 65 years) with secondary unilateral LLL. All patients underwent supermicrosurgical LVA. Read More

View Article and Full-Text PDF

A Rapidly Accumulating Effusion in an Immunocompetent Woman.

Chest 2022 Jun;161(6):e377-e382

Division of Hematology/Oncology, Lenox Hill Hospital, New York, NY.

Case Presentation: An 87-year-old woman with a medical history of stroke, paroxysmal atrial fibrillation, type 2 diabetes mellitus, diastolic heart failure, and chronic bilateral lymphedema presents with 1 week of shortness of breath. The patient had a 20-pack-year smoking history and at baseline was able to ambulate freely without assistance. Her symptoms of dyspnea were mostly exertional and progressively worsening for 1 week before admission, despite compliance with her home furosemide. Read More

View Article and Full-Text PDF