13,230 results match your criteria Milker's Nodules


An Update on the Known Host Range of the Brazilian Vaccinia Virus: An Outbreak in Buffalo Calves.

Front Microbiol 2018 22;9:3327. Epub 2019 Jan 22.

Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Even nearly forty years after the eradication of smallpox, members of the family continue to be the focus of an increasing number of studies. Among these studies, prominently stands vaccinia virus, an orthopoxvirus that is associated with bovine vaccinia outbreaks. Although more frequently associated with infections in cattle and humans, the host range of vaccinia virus is not restricted only to these hosts. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350457PMC
January 2019
2 Reads

The Role of microRNAs in the viral Infections.

Curr Pharm Des 2019 Jan 10. Epub 2019 Jan 10.

Computational Optics Research Group, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City. Viet Nam.

MicroRNAs (miRNAs) are non-coding RNAs with 19 to 24 nucleotides which are evolutionally conserved. MicroRNAs play a regulatory role in many cellular functions such as immune mechanisms, apoptosis, and tumorigenesis. The main function of miRNAs is the post-transcriptional regulation of gene expression via mRNA degradation or inhibition of translation. Read More

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http://www.eurekaselect.com/168861/article
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http://dx.doi.org/10.2174/1381612825666190110161034DOI Listing
January 2019
6 Reads

Comparison of the sensitivity of three cell cultures to ORFV.

BMC Vet Res 2019 Jan 7;15(1):13. Epub 2019 Jan 7.

State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou, 730046, China.

Background: Contagious ecthyma (CE) appears in the countries and regions containing goat and sheep farms, and it is considered a global epidemic. CE not only severely endangers the healthy development of the sheep and goat industries but also threatens human health. For viral infectious diseases, fast and effective isolation and culture of the pathogen is critical for CE diagnosis, and for disease prevention and control. Read More

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http://dx.doi.org/10.1186/s12917-018-1760-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322270PMC
January 2019
3 Reads

Human Molecular Genetics Has Not Yet Contributed to Measurable Public Health Advances.

Perspect Biol Med 2018 ;61(4):537-549

For more than half a century, we have lived in a world dominated by the idea that the gene is the central and primary agent in biology, an era some have called the "Genetic Age." Each decade since the discovery of the double-helical structure of DNA in 1953 has seen scientific advances in genetics, discoveries that have led to at least 17 Nobel Prizes. Although the time span occupied by the Genetic Age has also been a time of great public health advances, no advance in human molecular genetics can be shown to have had any measurable effect on any public health parameter of importance. Read More

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http://dx.doi.org/10.1353/pbm.2018.0063DOI Listing
January 2019
2 Reads

Sounding the alarm: Defining thresholds to trigger a public health response to monkeypox.

PLoS Negl Trop Dis 2018 12 20;12(12):e0007034. Epub 2018 Dec 20.

Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.

Endemic to the Democratic Republic of the Congo (DRC), monkeypox is a zoonotic disease that causes smallpox-like illness in humans. Observed fluctuations in reported cases over time raises questions about when it is appropriate to mount a public health response, and what specific actions should be taken. We evaluated three different thresholds to differentiate between baseline and heightened disease incidence, and propose a novel, tiered algorithm for public health action. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319745PMC
December 2018
2 Reads

Seroprevalence and participatory epidemiology of camelpox in Afar region of Ethiopia.

Prev Vet Med 2018 Dec 12;161:25-32. Epub 2018 Oct 12.

Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University, Greenvale, NY, USA. Electronic address:

Camelpox is endemic in most camel rearing regions of the world, causing significant economic losses. However, its epidemiology is not extensively investigated. We conducted a cross sectional seroprevalence study of camelpox in Amibara and Awash Fentale districts in Afar region of Ethiopia from November 2014 to May 2015. Read More

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http://dx.doi.org/10.1016/j.prevetmed.2018.10.003DOI Listing
December 2018
21 Reads

Oral Tecovirimat for the Treatment of Smallpox.

N Engl J Med 2018 11;379(21):2084-2085

Global Health Institute, Antwerp, Belgium

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http://www.nejm.org/doi/10.1056/NEJMc1811044
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http://dx.doi.org/10.1056/NEJMc1811044DOI Listing
November 2018
12 Reads

Monkeypox - Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era.

Int J Infect Dis 2019 Jan 16;78:78-84. Epub 2018 Nov 16.

Division of Infection and Immunity, Center for Clinical Microbiology, University College London, United Kingdom; The National Institute of Health Research Biomedical Research Centre at UCL Hospitals, London, United Kingdom. Electronic address:

The identification of monkeypox in 3 separate patients in the United Kingdom in September raised media and political attention on an emerging public health threat. Nigeria, whose last confirmed case of monkeypox was in 1978, is currently experiencing an unusually large and outbreak of human monkeypox cases, a 'One Human-Environmental-Animal Health' approach is being effectively used to define and tackle the outbreak. As of 13th October 2018, there have been one hundred and sixteen confirmed cases the majority of whom are under 40 years. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.11.008DOI Listing
January 2019
12 Reads
2.330 Impact Factor

Seroprevalence and risk factors of lumpy skin disease in Ethiopia.

Prev Vet Med 2018 Nov 1;160:99-104. Epub 2018 Oct 1.

Quantitative Veterinary Epidemiology, Wageningen University & Research, P.O. Box 338, 6700 AH, Wageningen, the Netherlands.

Lumpy skin disease (LSD) is an acute or inapparent viral disease of cattle which is endemic in many African and Middle East countries. LSD is one of the major transboundary livestock diseases in Ethiopia. A cross-sectional study using multistage cluster sampling was undertaken in central and north-western parts of Ethiopia with the objectives to estimate seroprevalence and to identify and quantify risk factors contributing to the occurrence of the disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01675877183053
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http://dx.doi.org/10.1016/j.prevetmed.2018.09.029DOI Listing
November 2018
2 Reads

New Insights into the Evolutionary and Genomic Landscape of Molluscum Contagiosum Virus (MCV) based on Nine MCV1 and Six MCV2 Complete Genome Sequences.

Viruses 2018 10 26;10(11). Epub 2018 Oct 26.

Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, SI-1000 Ljubljana, Slovenia.

Molluscum contagiosum virus (MCV) is the sole member of the genus and the causative agent of molluscum contagiosum (MC), a common skin disease. Although it is an important and frequent human pathogen, its genetic landscape and evolutionary history remain largely unknown. In this study, ten novel complete MCV genome sequences of the two most common MCV genotypes were determined (five MCV1 and five MCV2 sequences) and analyzed together with all MCV complete genomes previously deposited in freely accessible sequence repositories (four MCV1 and a single MCV2). Read More

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http://www.mdpi.com/1999-4915/10/11/586
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http://dx.doi.org/10.3390/v10110586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266040PMC
October 2018
8 Reads

Molluscum contagiosum virus infection can trigger atopic dermatitis disease onset or flare.

Cutis 2018 Sep;102(3):191-194

Departments of Dermatology and Pediatrics, Mt Sinai St. Luke's of the Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Predisposition to cutaneous viral infections is known to be a minor criterion of Hanifin and Rajka's diagnostic standard of atopic dermatitis (AD); however, the causal relationship between molluscum contagiosum virus (MCV) infection and AD onset or aggravation has not been widely explored. The objective of this study was to identify pediatric patients with AD onset or flare triggered by MCV infection as well as to characterize the setting under which MCV may trigger AD onset or flares in children. Fifty children with prior or current MCV infection presenting sequentially to an outpatient pediatric dermatology practice over a 1-month period were evaluated. Read More

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September 2018

Detection of Fowlpox virus carrying distinct genome segments of Reticuloendotheliosis virus.

Virus Res 2019 01 22;260:53-59. Epub 2018 Oct 22.

Animal Disease Research and Diagnostic Laboratory (ADRDL), Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA. Electronic address:

Fowlpox virus (FWPV), the type species of the genus Avipoxvirus family Poxviridae, is a large double-stranded DNA virus that causes fowlpox in chickens and turkeys. Notably, sequences of the avian retrovirus reticuloendotheliosis virus (REV) are frequently found integrated into the genome of FWPV. While some FWPV strains carry remnants of the REV long terminal repeats (LTRs), other strains have been shown to contain insertions of nearly the full-length REV provirus in their genome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01681702183055
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http://dx.doi.org/10.1016/j.virusres.2018.10.017DOI Listing
January 2019
13 Reads
2.324 Impact Factor

Evidence of avian poxvirus and papillomavirus infection in Gyps fulvus in Italy.

Arch Virol 2019 Jan 5;164(1):291-295. Epub 2018 Oct 5.

Faculty of Veterinary Medicine, University of Teramo, Loc. Piano D'Accio, 64100, Teramo, Italy.

The identification of avian poxvirus and avian papillomavirus associated with cutaneous lesions in griffon vultures (Gyps fulvus) by histopathology, electron microscopy and PCR analysis is reported. Sequence analysis of the fpv140 gene revealed 99% identity to two poxviruses obtained from a white-tailed sea eagle (Haliaeetus albicilla) and a common buzzard (Buteo buteo). Partial sequence of the papillomavirus L1 gene showed sequence similarity to papillomavirus LI genes from African grey parrot (Psittacus erithacus) (69% identity), duck (Anas platyrhynchos) (68% identity), and yellow-necked francolin (Francolinus leucoscepus) (66% identity). Read More

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http://link.springer.com/10.1007/s00705-018-4055-8
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http://dx.doi.org/10.1007/s00705-018-4055-8DOI Listing
January 2019
3 Reads

Synthetic horsepox viruses and the continuing debate about dual use research.

PLoS Pathog 2018 10 4;14(10):e1007025. Epub 2018 Oct 4.

Department of Medical Microbiology & Immunology, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.plos.org/10.1371/journal.ppat.1007025
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http://dx.doi.org/10.1371/journal.ppat.1007025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171955PMC
October 2018
14 Reads

Inoculating science against potential pandemics and information hazards.

Authors:
Kevin M Esvelt

PLoS Pathog 2018 10 4;14(10):e1007286. Epub 2018 Oct 4.

MIT Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

The recent de novo assembly of horsepox is an instructive example of an information hazard: published methods enabling poxvirus synthesis led to media coverage spelling out the implications, efficiently disseminating true information that might be used to cause harm. Whether or not the benefits justified the risks, the horsepox saga provides ample reason to upgrade the current system for screening synthesized DNA for hazardous sequences, which does not cover the majority of firms and cannot reliably prevent the assembly of potentially pandemic pathogens. An upgraded system might leverage one-way encryption to confidentially scrutinize virtually all commercial production by a cooperative international network of servers whose integrity can be verified by third parties. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171951PMC
October 2018
3 Reads

Horsepox and the need for a new norm, more transparency, and stronger oversight for experiments that pose pandemic risks.

Authors:
Tom Inglesby

PLoS Pathog 2018 10 4;14(10):e1007129. Epub 2018 Oct 4.

Johns Hopkins Center for Health Security, Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171949PMC
October 2018

Monkeypox contacts: a puzzling problem.

Authors:
The Lancet

Lancet 2018 09 20;392(10152):986. Epub 2018 Sep 20.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183225
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http://dx.doi.org/10.1016/S0140-6736(18)32254-2DOI Listing
September 2018
10 Reads

Molecular identification and microscopic characterization of poxvirus in a Guiana dolphin and a common bottlenose dolphin, Brazil.

Dis Aquat Organ 2018 09;130(3):177-185

Laboratório de Patologia Comparada de Animais Selvagens, Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP 05508-270, Brazil.

The poxviruses identified in cetaceans are associated with characteristic tattoo or ring skin lesions. However, little is known regarding the prevalence and progression of these lesions and the molecular characterization of cetacean poxviruses in the Southern Hemisphere. This manuscript describes the progression of poxvirus-like skin lesions in 5 free-ranging Guiana dolphins Sotalia guianensis. Read More

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http://dx.doi.org/10.3354/dao03271DOI Listing
September 2018
10 Reads

Validation of a diagnostic tool for the diagnosis of lumpy skin disease.

Vet Dermatol 2018 Dec 24;29(6):532-e178. Epub 2018 Sep 24.

International Livestock Research Institute (BecA-ILRI hub), PO Box 30709, Nairobi, 00100, Kenya.

Background: Lumpy skin disease (LSD) is caused by LSD virus which is a member of the Capripoxvirus (CaPV) genus. Although PCR provides for a rapid and sensitive diagnosis, it has limited use due to its complexity in terms of cost, time and equipment. Loop-mediated isothermal amplification (LAMP) is a simple, specific and cost-effective method with a diagnostic accuracy similar to PCR. Read More

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http://dx.doi.org/10.1111/vde.12690DOI Listing
December 2018
12 Reads

Sporadic cases of lumpy skin disease among cattle in Sharkia province, Egypt: Genetic characterization of lumpy skin disease virus isolates and pathological findings.

Vet World 2018 Aug 23;11(8):1150-1158. Epub 2018 Aug 23.

Department of Virology, Faculty of Veterinary Medicine, Zagazig University, 44511-Zagazig, Sharkia Province, Egypt.

Background And Aim: Lumpy skin disease (LSD) is a highly infectious viral disease upsetting cattle, caused by LSD virus (LSDV) within the family . Sporadic cases of LSD have been observed in cattle previously vaccinated with the Romanian sheep poxvirus (SPPV) vaccine during the summer of 2016 in Sharkia province, Egypt. The present study was undertaken to perform molecular characterization of LSDV strains which circulated in this period as well as investigate their phylogenetic relatedness with published reference capripoxvirus genome sequences

Materials And Methods: A total of 82 skin nodules, as well as 5 lymph nodes, were collected from suspect LSD cases, and the virus was isolated in embryonated chicken eggs (ECEs). Read More

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http://www.veterinaryworld.org/Vol.11/August-2018/20.html
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http://dx.doi.org/10.14202/vetworld.2018.1150-1158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141277PMC
August 2018
6 Reads

Characterization of mule deerpox virus in Florida white-tailed deer fawns expands the known host and geographic range of this emerging pathogen.

Arch Virol 2019 Jan 21;164(1):51-61. Epub 2018 Sep 21.

Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Bldg 1379, Mowry Road, Gainesville, FL, 32611, USA.

Infections caused by mule deerpox virus (MDPV) have been sporadically reported in North American cervids. White-tailed deer (Odocoileus virginianus) fawns from a farm located in South Central Florida presented with ulcerative and crusting lesions on the coronary band as well as the mucocutaneous tissues of the head. Evaluation of the crusted skin lesions was undertaken using microscopic pathology and molecular techniques. Read More

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http://dx.doi.org/10.1007/s00705-018-3991-7DOI Listing
January 2019
5 Reads
2.282 Impact Factor

Respiratory infection due to direct contact with rabbit-skin powder contaminated by vaccinia virus.

Int J Infect Dis 2018 Nov 12;76:70-72. Epub 2018 Sep 12.

Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China. Electronic address:

Vaccinia virus infection was diagnosed in five male workers directly exposed to rabbit-skin powder contaminated by vaccinia virus via skin contact and inhalation. Four of the workers had been vaccinated against smallpox. Their clinical symptoms were severe, especially in the lungs; however, all symptoms improved after treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712183451
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http://dx.doi.org/10.1016/j.ijid.2018.09.005DOI Listing
November 2018
5 Reads

Identification and phylogenetic analysis of clade C Avipoxvirus in a fowlpox outbreak in exotic psittacines in southern Brazil.

J Vet Diagn Invest 2018 Nov 10;30(6):946-950. Epub 2018 Sep 10.

Departments of Preventive Veterinary Medicine (Murer, Westenhofen, Lovato), Brazil.

Fowlpox is one of the oldest diseases reported in birds. The causative genus Avipoxvirus affects ~232 domestic and wild species. We present herein the history, clinical findings, and macroscopic and histologic lesions caused by a clade C poxvirus in an exotic psittacine breeding colony in southern Brazil. Read More

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http://dx.doi.org/10.1177/1040638718775146DOI Listing
November 2018
2 Reads

The Virology of Taterapox Virus In Vitro.

Viruses 2018 08 29;10(9). Epub 2018 Aug 29.

Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St. Louis, MO 63104, USA.

Taterapox virus (TATV) is phylogenetically the closest related virus to variola-the etiological agent of smallpox. Despite the similarity, few studies have evaluated the virus. In vivo, TATV can infect several animals but produces an inapparent infection in wild-type mice; however, TATV does cause morbidity and mortality in some immunocompromised strains. Read More

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http://dx.doi.org/10.3390/v10090463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163509PMC
August 2018
16 Reads

Evaluation of a recombinant major envelope protein (F1L) based indirect- ELISA for sero-diagnosis of orf in sheep and goats.

J Virol Methods 2018 11 24;261:112-120. Epub 2018 Aug 24.

ICAR- National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru, 560064, Karnataka, India.

Orf or contagious ecthyma, is a highly contagious transboundary disease of sheep and goats. For sero-diagnosis of orf, recombinant antigen based assays are considered as alternatives to conventional approaches such as serum neutralization test (SNT) and counter-immuno-electrophoresis (CIE). A major envelope protein of orf virus (ORFV), F1L, is highly immunogenic and is a candidate for use in these assays. Read More

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http://dx.doi.org/10.1016/j.jviromet.2018.08.015DOI Listing
November 2018
17 Reads
1.883 Impact Factor

Reviewing the use of imiquimod for molluscum contagiosum.

Dermatol Online J 2018 Aug 23;24(6). Epub 2018 Aug 23.

Pediatrics, Johns Hopkins Children's Center, Baltimore, Maryland.

We discuss imiquimod associated with non-application site mucosal reactions and two of our own clinical cases. In one of our patients, erosive cheilitis developed in a young boy after using topical imiquimod 5% cream for 5 nights weekly on bilateral cheeks, chin, and near vermillion border for molluscum contagiosum. The case is discussed with concerns for imiquimod use in molluscum contagiosum when used near mucosal surfaces. Read More

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August 2018
3 Reads

Sequence analysis of haemagglutinin gene of camelpox viruses shows deletion leading to frameshift: Circulation of diverse clusters among camelpox viruses.

Transbound Emerg Dis 2018 Dec 13;65(6):1920-1934. Epub 2018 Aug 13.

Division of Virology, ICAR-Indian Veterinary Research Institute, Mukteswar, Uttarakhand, India.

Orthopoxviruses (OPVs) have broad host range infecting a variety of species along with gene-specific determinants. Several genes including haemagglutinin (HA) are used for differentiation of OPVs. Among poxviruses, OPVs are sole members encoding HA protein as part of extracellular enveloped virion membrane. Read More

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http://dx.doi.org/10.1111/tbed.12973DOI Listing
December 2018
5 Reads
2.944 Impact Factor

Ebola virus - prospects for a novel virus-like-particle-expressing modified vaccinia Ankara-based vaccine.

Expert Rev Vaccines 2018 09 20;17(9):769-771. Epub 2018 Aug 20.

b Laboratory of Virology, Division of Intramural Research , National Institute of Allergy and Infectious Diseases, National Institutes of Health , Hamilton , MT , USA.

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http://dx.doi.org/10.1080/14760584.2018.1510775DOI Listing
September 2018
6 Reads

Evolutionary view of the AIDS process.

Authors:
Vladimir Zajac

J Int Med Res 2018 Oct 8;46(10):4032-4038. Epub 2018 Aug 8.

Cancer Research Institute BMC SAS, Bratislava, Slovakia.

It is generally accepted that human immunodeficiency virus (HIV) is the etiological agent of acquired immune deficiency syndrome. According to this claim, HIV was transferred to humans from contact with monkeys around 35-50 years ago. However, this claim has not been sufficiently confirmed epidemiologically. Read More

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http://dx.doi.org/10.1177/0300060518786919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166329PMC
October 2018
5 Reads

Rapid whole-genome based typing and surveillance of avipoxviruses using nanopore sequencing.

J Virol Methods 2018 11 4;261:34-39. Epub 2018 Aug 4.

Université de Toulouse, ENVT, INRA, UMR 1225, 31076 Toulouse, France. Electronic address:

Avian pox is an infectious disease caused by avipoxviruses (APV), resulting in cutaneous and/or tracheal lesions. Poxviruses share large genome sizes (from 130 to 360 kb), featuring repetitions, deletions or insertions as a result of a long-term recombination history. The increasing performances of next-generation sequencing (NGS) opened new opportunities for surveillance of poxviruses, based on timely and affordable workflows. Read More

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http://dx.doi.org/10.1016/j.jviromet.2018.08.003DOI Listing
November 2018
4 Reads

Development of recombinant goatpox virus expressing Echinococcus granulosus EG95 vaccine antigen.

J Virol Methods 2018 11 4;261:28-33. Epub 2018 Aug 4.

OIE Reference Laboratory for Peste des Petits Ruminants, National Research Center for Exotic Animal Diseases, China Animal Health and Epidemiology Center, No.369 Nanjing Road, Qingdao, Shandong 266032, China. Electronic address:

Goatpox disease and cystic hydatidosis may be simultaneously endemic in a given area. Their pathogens are goatpox virus (GPV) and Echinococcus granulosus (E. granulosus), respectively. Read More

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http://dx.doi.org/10.1016/j.jviromet.2018.08.002DOI Listing
November 2018
3 Reads

Flavobacteria as secondary pathogens in carp suffering from koi sleepy disease.

J Fish Dis 2018 Nov 1;41(11):1631-1642. Epub 2018 Aug 1.

Fish Disease Research Unit, Institute for Parasitology, University of Veterinary Medicine, Hannover, Germany.

Koi sleepy disease (KSD) is a disease with increasing importance in global common carp aquaculture. Despite the fact that carp edema virus (CEV) is most likely the causative agent of KSD, the disease often presents itself as multifactorial with several parasites and bacteria species present on gills, skin or in internal organs. Therefore, in this study, we analysed and presented initial results on an interaction of flavobacteria and CEV in the development of clinical KSD in carp suffering from proliferative gill disease. Read More

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http://dx.doi.org/10.1111/jfd.12872DOI Listing
November 2018
2 Reads

Economic cost of lumpy skin disease outbreaks in three Balkan countries: Albania, Bulgaria and the Former Yugoslav Republic of Macedonia (2016-2017).

Transbound Emerg Dis 2018 Dec 10;65(6):1680-1688. Epub 2018 Jul 10.

Regional Office for Europe and Central Asia, Food and Agriculture Organization, Budapest, Hungary.

Lumpy skin disease (LSD) is an emerging viral disease that was detected for the first time in the Balkan Peninsula in Greece in 2015. In April 2016, there was a reoccurrence in Greece and the spread of the disease for the first time into Bulgaria, the Former Yugoslav Republic of Macedonia, Serbia, Kosovo, Albania and Montenegro. The veterinary services of the countries responded with different strategies to control the disease, mostly based on mass vaccination campaigns and diverse stamping out approaches. Read More

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http://doi.wiley.com/10.1111/tbed.12926
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http://dx.doi.org/10.1111/tbed.12926DOI Listing
December 2018
10 Reads

Suitability of group-level oral fluid sampling in ruminant populations for lumpy skin disease virus detection.

Vet Microbiol 2018 Jul 31;221:44-48. Epub 2018 May 31.

Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493, Greifswald, Insel Riems, Germany.

The geographic expansion of Lumpy skin disease (LSD) from the near East into the European Union highlighted again the need for appropriate disease detection tools applicable to animal host populations where access to individual animals is difficult. This is of particular importance considering that the clinical manifestation of LSD is often mild making early disease detection challenging under the above-mentioned conditions. Building on positive experiences of group-level oral fluid sampling for pathogen detection as it is known to work for swine herds and wild boar, the concept was transferred to ruminants. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.05.022DOI Listing
July 2018
7 Reads

Never Mind the Science, Here's the Convention on Biological Diversity: Viral Sovereignty in the Smallpox Destruction Debate.

J Law Med 2018 Feb;25(2):429-447

Griffith Law School, Griffith University, Gold Coast, Queensland.

Since the eradication of smallpox was declared in 1980, debate has ensued over what to do with the remaining stocks of the causative agent, variola virus. For more than three decades the World Health Organization has resolved to destroy the virus isolates, now maintained in high-security laboratories in the Russian Federation and the United States, and each time the deadline has been deferred. The legal facets of this debate have been largely overlooked. Read More

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February 2018
3 Reads

Oral Tecovirimat for the Treatment of Smallpox.

N Engl J Med 2018 07;379(1):44-53

From SIGA Technologies, Corvallis, OR.

Background: Smallpox was declared eradicated in 1980, but variola virus (VARV), which causes smallpox, still exists. There is no known effective treatment for smallpox; therefore, tecovirimat is being developed as an oral smallpox therapy. Because clinical trials in a context of natural disease are not possible, an alternative developmental path to evaluate efficacy and safety was needed. Read More

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http://dx.doi.org/10.1056/NEJMoa1705688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086581PMC
July 2018
4 Reads

Molluscum contagiosum arising in a melanocytic congenital nevus.

Pediatr Dermatol 2018 Sep 4;35(5):e310-e311. Epub 2018 Jul 4.

Section of Dermatology, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

Molluscum contagiosum within a congenital melanocytic nevus has rarely been reported. We report a 6-year-old child with molluscum contagiosum infection arising within an intermediate melanocytic congenital nevus of the thigh, associated with itching and occasional bleeding. Dermoscopy lead to the correct diagnosis, but histologic confirmation with shave biopsy was performed to reassure the parents and allow mechanical removal of the lesions using curettage. Read More

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http://dx.doi.org/10.1111/pde.13591DOI Listing
September 2018
5 Reads

Phylogenetic analysis of the lumpy skin disease viruses in northwest of Iran.

Trop Anim Health Prod 2018 Dec 13;50(8):1851-1858. Epub 2018 Jun 13.

Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

Lumpy skin disease (LSD) is a devastating viral disease of cattle which has recently spread from Africa into the countries of the Middle East. The aim of the present study was to investigate the relationships among lumpy skin disease viruses (LSDV) isolated from different regions of Iran and the origin and spread of these viruses. In this study, a total of 234 blood samples from clinically affected animals from four provinces in the northwest of Iran were screened for LSDV using polymerase chain reaction (PCR). Read More

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http://dx.doi.org/10.1007/s11250-018-1634-3DOI Listing
December 2018
16 Reads

Characterisation of putative immunomodulatory gene knockouts of lumpy skin disease virus in cattle towards an improved vaccine.

Vaccine 2018 07 22;36(31):4708-4715. Epub 2018 Jun 22.

Agricultural Research Council - Onderstepoort Veterinary Research, Private Bag X5, Onderstepoort 0110, South Africa; Department Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, South Africa.

Lumpy skin disease virus (LSDV) is responsible for causing severe economic losses to cattle farmers throughout Africa, the Middle East, and more recently, South-Eastern Europe and Russia. It belongs to the Capripoxvirus genus of the Poxviridae family, with closely related sheeppox and goatpox viruses. Like other poxviruses, the viral genome codes for a number of genes with putative immunomodulatory capabilities. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.06.017DOI Listing
July 2018
34 Reads

A many probes-one spot hybridization oligonucleotide microarray.

Anal Bioanal Chem 2018 Sep 22;410(23):5817-5823. Epub 2018 Jun 22.

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, pr. Lavrentieva 8, Novosibirsk, 630090, Russia.

A variant of the hybridization oligonucleotide microarray, utilizing the principle of many probes-one spot (MPOS-microarrays), is proposed. A case study based on Orthopoxviruses (Variola, Monkeypox, and Ectromelia viruses) demonstrates a considerable increase in the fluorescence signal (up to 100-fold) when several oligonucleotide probes are printed to one spot. Moreover, the specificity of detection also increases (almost 1000-fold), allowing the use of probes that individually lack such high specificity. Read More

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http://dx.doi.org/10.1007/s00216-018-1190-8DOI Listing
September 2018
16 Reads

Detection of vaccine-like lumpy skin disease virus in cattle and Musca domestica L. flies in an outbreak of lumpy skin disease in Russia in 2017.

Transbound Emerg Dis 2018 Oct 22;65(5):1137-1144. Epub 2018 Jun 22.

Federal Center for Animal Health, Vladimir, Russia.

Since 2012, lumpy skin disease virus (LSDV) has been spreading from the Middle East to south-east Europe and Russia. Although vaccination campaigns have managed to contain LSDV outbreaks, the risk of further spread is still high. The most likely route of LSDV transmission in short distance spread is vector-borne. Read More

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http://dx.doi.org/10.1111/tbed.12897DOI Listing
October 2018
22 Reads

Intranasal monkeypox marmoset model: Prophylactic antibody treatment provides benefit against severe monkeypox virus disease.

PLoS Negl Trop Dis 2018 06 21;12(6):e0006581. Epub 2018 Jun 21.

United States Army Medical Research Institute of Infectious Diseases, Virology Division, Fort Detrick Maryland, United States of America.

Concerns regarding outbreaks of human monkeypox or the potential reintroduction of smallpox into an immunological naïve population have prompted the development of animal models and countermeasures. Here we present a marmoset model of monkeypox and smallpox disease utilizing a relevant poxvirus via a natural exposure route. We found that 1000 plaque forming units (PFU) of Monkeypox virus was sufficient to recapitulate smallpox disease, to include an incubation period of approximately 13 days, followed by the onset of rash, and death between 15 and 17 days. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029809PMC
June 2018
3 Reads

Safety and efficacy of topical cantharidin for the treatment of pediatric molluscum contagiosum: a prospective, randomized, double-blind, placebo-controlled pilot trial.

Int J Dermatol 2018 Aug 15;57(8):1001-1006. Epub 2018 Jun 15.

Department of Internal Medicine, Division of Dermatology, Albert Einstein College of Medicine, Bronx, NY, USA.

Topical cantharidin is a commonly used treatment for molluscum contagiosum (MC). However, studies validating its safety and efficacy are limited. We conducted a 6-week, randomized, double-blind, placebo-controlled trial with subsequent open-label extension to assess the safety and effectiveness of cantharidin in treating pediatric MC. Read More

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http://dx.doi.org/10.1111/ijd.14079DOI Listing
August 2018
20 Reads

Novel and highly sensitive SYBR® Green real-time pcr for poxvirus detection in odontocete cetaceans.

J Virol Methods 2018 09 8;259:45-49. Epub 2018 Jun 8.

Centro de Investigación en Sanidad Animal (INIA-CISA), Ctra Algete el Casar s/n, Valdeolmos, Madrid, 28130, Spain. Electronic address:

Poxviruses are emerging pathogens in cetaceans, temporarily named 'Cetaceanpoxvirus' (CePV, family Poxviridae), classified into two main lineages: CePV-1 in odontocetes and CePV-2 in mysticetes. Only a few studies performed the molecular detection of CePVs, based on DNA-polymerase gene and/or DNA-topoisomerase I gene amplification. Herein we describe a new real-time PCR assay based on SYBR Green and a new primer set to detect a 150 bp fragment of CePV DNA-polymerase gene, also effective for conventional PCR detection. Read More

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http://dx.doi.org/10.1016/j.jviromet.2018.06.002DOI Listing
September 2018
4 Reads

Risk of introduction of lumpy skin disease in France by the import of vectors in animal trucks.

PLoS One 2018 11;13(6):e0198506. Epub 2018 Jun 11.

Members of the Expert Committee for Animal Health and Welfare, ANSES, Maisons-Alfort, France.

Background: The lumpy skin disease virus (LSDV) is a dsDNA virus belonging to the Poxviridae family and the Capripoxvirus genus. Lumpy skin diseases (LSD) is a highly contagious transboundary disease in cattle producing major economic losses. In 2014, the disease was first reported in the European Union (in Cyprus); it was then reported in 2015 (in Greece) and has spread through different Balkan countries in 2016. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198506PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995388PMC
December 2018
6 Reads

Batf3-Dependent Dendritic Cells Promote Optimal CD8 T Cell Responses against Respiratory Poxvirus Infection.

J Virol 2018 08 31;92(16). Epub 2018 Jul 31.

Department of Pathology, Immunology & Laboratory Medicine, University of Florida, Gainesville, Florida, USA

Respiratory infection with vaccinia virus (VacV) elicits robust CD8 T cell responses that play an important role in host resistance. In the lung, VacV encounters multiple tissue-resident antigen-presenting cell (APC) populations, but which cell plays a dominant role in priming of virus-specific CD8 effector T cell responses remains poorly defined. We used Batf3 mice to investigate the impact of CD103 and CD8α dendritic cell (DC) deficiency on anti-VacV CD8 T cell responses. Read More

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http://dx.doi.org/10.1128/JVI.00495-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069197PMC
August 2018
4 Reads

Serological and clinical evaluation of the Yugoslavian RM65 sheep pox strain vaccine use in cattle against lumpy skin disease.

Transbound Emerg Dis 2018 Dec 6;65(6):1657-1663. Epub 2018 Jun 6.

Independent Veterinary Consultant, The Pirbright Institute, Pirbright, Surrey, UK.

Lumpy skin disease (LSD) is an emerging infectious disease of cattle. Since 2012, it has been seen throughout the Middle East region. The aim of this study was to compare the humoral response of three different dosages of the RM65 sheep pox (SPP) vaccine to assess the use of ten times sheep dose of the RM65 vaccine against lumpy skin disease, and to explore the possible causes of, and characterize the side effects caused by the RM65 vaccine. Read More

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http://dx.doi.org/10.1111/tbed.12923DOI Listing
December 2018
1 Read

Molecular characterization of lumpy skin disease virus in Namibia, 2017.

Arch Virol 2018 Sep 4;163(9):2525-2529. Epub 2018 Jun 4.

Animal Production and Health Laboratory, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Wagramer Strasse 5, P.O. Box 100, 1400, Vienna, Austria.

Between January and July 2017, lumpy skin disease (LSD) outbreaks were reported in cattle in Namibia. DNA was extracted from skin biopsies taken from 32 cattle, and the RNA polymerase 30 kDa subunit (RPO30) gene of the LSD virus (LSDV) was successfully amplified by PCR. Phylogenetic analysis revealed that the newly sequenced LSDV isolates from Namibia were identical to LSDV isolates identified previously in Burkina Faso, Egypt, Greece, Niger, Serbia and South Africa. Read More

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http://dx.doi.org/10.1007/s00705-018-3891-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132926PMC
September 2018
7 Reads

Spatial and temporal distribution of lumpy skin disease outbreaks in Uganda (2002-2016).

BMC Vet Res 2018 Jun 1;14(1):174. Epub 2018 Jun 1.

College of Veterinary Medicine, Animal resources and Biosecurity, Makerere University, P.O.BOX 7062, Kampala, Uganda.

Background: Lumpy skin disease (LSD) is a devastating transboundary viral disease of cattle which causes significant loss in production. Although this disease has been reported in Uganda and throughout East Africa, there is almost no information about its epidemiology, spatial or spatio-temporal distribution. We carried out a retrospective study on the epidemiology of LSD in Uganda between the years 2002 and 2016, using data on reported outbreaks collected monthly by the central government veterinary administration. Read More

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http://dx.doi.org/10.1186/s12917-018-1503-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984736PMC
June 2018
29 Reads
1.780 Impact Factor