13,271 results match your criteria Milker's Nodules


Humoral immune response to repeated lumpy skin disease virus vaccination and performance of serological tests.

BMC Vet Res 2019 Mar 6;15(1):80. Epub 2019 Mar 6.

Friedrich-Loeffler-Institut, Südufer 10, D-17493, Greifswald-Insel Riems, Germany.

Background: In the presented study we investigated the development of the humoral immune response against LSDV during the process of re-vaccination of cattle over a time span of 5 months. In addition, the performance of different serological techniques for antibody detection against LSDV was compared. For sample collection, an area without previous LSD outbreak reports in Serbia was selected. Read More

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http://dx.doi.org/10.1186/s12917-019-1831-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404298PMC
March 2019
2 Reads

Prokaryotic expression, purification and evaluation of goatpox virus ORF117 protein as a diagnostic antigen in indirect ELISA to detect goatpox.

Arch Virol 2019 Apr 18;164(4):1049-1058. Epub 2019 Feb 18.

Division of Virology, ICAR-Indian Veterinary Research Institute, Mukteswar, Nainital, Uttarakhand, 263 138, India.

Goatpox is an economically significant transboundary viral disease of goats that is caused by goatpox virus (GTPV). This study describes the prokaryotic expression of the GTPV ORF117 protein, a homologue of vaccinia virus A27L, and evaluation of its diagnostic potential in ELISA. The GTPV ORF117 gene was cloned into the pET32a vector to express recombinant ORF117 protein (rA27L) in E. Read More

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http://dx.doi.org/10.1007/s00705-019-04170-8DOI Listing
April 2019
1 Read
2.282 Impact Factor

A poxvirus pseudokinase represses viral DNA replication via a pathway antagonized by its paralog kinase.

PLoS Pathog 2019 02 15;15(2):e1007608. Epub 2019 Feb 15.

Nebraska Center for Virology, University of Nebraska, Lincoln, NE, United States of America.

Poxviruses employ sophisticated, but incompletely understood, signaling pathways that engage cellular defense mechanisms and simultaneously ensure viral factors are modulated properly. For example, the vaccinia B1 protein kinase plays a vital role in inactivating the cellular antiviral factor BAF, and likely orchestrates other pathways as well. In this study, we utilized experimental evolution of a B1 deletion virus to perform an unbiased search for suppressor mutations and identify novel pathways involving B1. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395007PMC
February 2019
3 Reads

An Update on the Known Host Range of the Brazilian Vaccinia Virus: An Outbreak in Buffalo Calves.

Front Microbiol 2018 22;9:3327. Epub 2019 Jan 22.

Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Even nearly forty years after the eradication of smallpox, members of the family continue to be the focus of an increasing number of studies. Among these studies, prominently stands vaccinia virus, an orthopoxvirus that is associated with bovine vaccinia outbreaks. Although more frequently associated with infections in cattle and humans, the host range of vaccinia virus is not restricted only to these hosts. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350457PMC
January 2019
3 Reads

Sequential detection of pseudocowpox virus and bovine papular stomatitis virus in a same calf in Japan.

J Vet Med Sci 2019 Mar 22;81(3):440-443. Epub 2019 Jan 22.

Laboratory of Food and Environmental Hygiene, Cooperative Department of Veterinary Medicine, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan.

We detected parapoxviruses from environmental samples and calves with and without intraoral clinical signs and conducted molecular and serological analyses. Pseudocowpox virus (PCPV) was detected from a calf showing anorexia, frothy salivation, and erosion in the mucosa of the lip and tongue. At the time that PCPV was detected, bovine papular stomatitis viruses (BPSVs) were detected in environmental samples as well as in calves without intraoral clinical signs. Read More

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http://dx.doi.org/10.1292/jvms.18-0367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451898PMC
March 2019
2 Reads

The Role of microRNAs in the Viral Infections.

Curr Pharm Des 2018 ;24(39):4659-4667

Computational Optics Research Group, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

MicroRNAs (miRNAs) are non-coding RNAs with 19 to 24 nucleotides which are evolutionally conserved. MicroRNAs play a regulatory role in many cellular functions such as immune mechanisms, apoptosis, and tumorigenesis. The main function of miRNAs is the post-transcriptional regulation of gene expression via mRNA degradation or inhibition of translation. Read More

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http://www.eurekaselect.com/168861/article
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http://dx.doi.org/10.2174/1381612825666190110161034DOI Listing
January 2018
14 Reads

Comparison of the sensitivity of three cell cultures to ORFV.

BMC Vet Res 2019 Jan 7;15(1):13. Epub 2019 Jan 7.

State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou, 730046, China.

Background: Contagious ecthyma (CE) appears in the countries and regions containing goat and sheep farms, and it is considered a global epidemic. CE not only severely endangers the healthy development of the sheep and goat industries but also threatens human health. For viral infectious diseases, fast and effective isolation and culture of the pathogen is critical for CE diagnosis, and for disease prevention and control. Read More

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http://dx.doi.org/10.1186/s12917-018-1760-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322270PMC
January 2019
7 Reads

Human Molecular Genetics Has Not Yet Contributed to Measurable Public Health Advances.

Perspect Biol Med 2018 ;61(4):537-549

For more than half a century, we have lived in a world dominated by the idea that the gene is the central and primary agent in biology, an era some have called the "Genetic Age." Each decade since the discovery of the double-helical structure of DNA in 1953 has seen scientific advances in genetics, discoveries that have led to at least 17 Nobel Prizes. Although the time span occupied by the Genetic Age has also been a time of great public health advances, no advance in human molecular genetics can be shown to have had any measurable effect on any public health parameter of importance. Read More

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http://dx.doi.org/10.1353/pbm.2018.0063DOI Listing
January 2019
3 Reads

Poxvirus infection in a Steller's sea eagle (Haliaeetus pelagicus).

J Vet Med Sci 2019 Feb 1;81(2):338-342. Epub 2019 Jan 1.

Department of Pathogenetic Veterinary Science, United Graduated School of Veterinary Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

A severely emaciated adult Steller's sea eagle (Haliaeetus pelagicus) was found dead with electrocution-induced severe wing laceration, and with multiple cutaneous pock nodules at the periocular regions of both sides nearby the medial canthi and rhamphotheca. Histopathological examination of the nodules revealed hyperplasia of the epidermis with vacuolar degeneration and intracytoplasmic inclusion bodies (Bollinger bodies). The proventriculus was severely affected by nematodes and was ulcerated. Read More

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http://dx.doi.org/10.1292/jvms.18-0566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395218PMC
February 2019
2 Reads
0.782 Impact Factor

A virus-encoded type I interferon decoy receptor enables evasion of host immunity through cell-surface binding.

Nat Commun 2018 12 21;9(1):5440. Epub 2018 Dec 21.

Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), 28049, Madrid, Spain.

Soluble cytokine decoy receptors are potent immune modulatory reagents with therapeutic applications. Some virus-encoded secreted cytokine receptors interact with glycosaminoglycans expressed at the cell surface, but the biological significance of this activity in vivo is poorly understood. Here, we show the type I interferon binding protein (IFNα/βBP) encoded by vaccinia and ectromelia viruses requires of this cell binding activity to confer full virulence to these viruses and to retain immunomodulatory activity. Read More

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http://dx.doi.org/10.1038/s41467-018-07772-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303335PMC
December 2018
3 Reads

Sounding the alarm: Defining thresholds to trigger a public health response to monkeypox.

PLoS Negl Trop Dis 2018 12 20;12(12):e0007034. Epub 2018 Dec 20.

Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.

Endemic to the Democratic Republic of the Congo (DRC), monkeypox is a zoonotic disease that causes smallpox-like illness in humans. Observed fluctuations in reported cases over time raises questions about when it is appropriate to mount a public health response, and what specific actions should be taken. We evaluated three different thresholds to differentiate between baseline and heightened disease incidence, and propose a novel, tiered algorithm for public health action. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319745PMC
December 2018
4 Reads

Spatial analysis of lumpy skin disease in Eurasia-Predicting areas at risk for further spread within the region.

Transbound Emerg Dis 2019 Mar 28;66(2):813-822. Epub 2018 Dec 28.

Food and Agriculture Organization (FAO), Regional Office for Europe and Central Asia, Budapest, Hungary.

Data from affected lumpy skin disease (LSD) locations between July 2012 and September 2018 in the Balkans, Caucasus, and Middle East were retrieved from FAO's Global Animal Disease Information System (EMPRES-i) from the European Commission's Animal Disease Notification System (ADNS) and completed with data from the official veterinary services of some countries. During this period, a total of 7,593 locations from 22 countries were affected. Within this period, over 46,000 cattle were clinically affected by LSD, 3,700 animals died and 17,500 were slaughtered due to culling policies to stop the spread of the disease. Read More

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http://dx.doi.org/10.1111/tbed.13090DOI Listing
March 2019
4 Reads

Isolation and identification of a novel salmon gill poxvirus variant from Atlantic salmon in Eastern Canada.

J Fish Dis 2019 Feb 3;42(2):315-318. Epub 2018 Dec 3.

Gulf Fisheries Centre, Fisheries& Oceans Canada, Moncton, New Brunswick, Canada.

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http://dx.doi.org/10.1111/jfd.12922DOI Listing
February 2019
2 Reads

Seroprevalence and participatory epidemiology of camelpox in Afar region of Ethiopia.

Prev Vet Med 2018 Dec 12;161:25-32. Epub 2018 Oct 12.

Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University, Greenvale, NY, USA. Electronic address:

Camelpox is endemic in most camel rearing regions of the world, causing significant economic losses. However, its epidemiology is not extensively investigated. We conducted a cross sectional seroprevalence study of camelpox in Amibara and Awash Fentale districts in Afar region of Ethiopia from November 2014 to May 2015. Read More

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http://dx.doi.org/10.1016/j.prevetmed.2018.10.003DOI Listing
December 2018
28 Reads

Oral Tecovirimat for the Treatment of Smallpox.

N Engl J Med 2018 11;379(21):2084-2085

Global Health Institute, Antwerp, Belgium

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http://www.nejm.org/doi/10.1056/NEJMc1811044
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http://dx.doi.org/10.1056/NEJMc1811044DOI Listing
November 2018
17 Reads

Monkeypox - Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era.

Int J Infect Dis 2019 Jan 16;78:78-84. Epub 2018 Nov 16.

Division of Infection and Immunity, Center for Clinical Microbiology, University College London, United Kingdom; The National Institute of Health Research Biomedical Research Centre at UCL Hospitals, London, United Kingdom. Electronic address:

The identification of monkeypox in 3 separate patients in the United Kingdom in September raised media and political attention on an emerging public health threat. Nigeria, whose last confirmed case of monkeypox was in 1978, is currently experiencing an unusually large and outbreak of human monkeypox cases, a 'One Human-Environmental-Animal Health' approach is being effectively used to define and tackle the outbreak. As of 13th October 2018, there have been one hundred and sixteen confirmed cases the majority of whom are under 40 years. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.11.008DOI Listing
January 2019
13 Reads
2.330 Impact Factor

VARV B22R homologue as phylogenetic marker gene for Capripoxvirus classification and divergence time dating.

Virus Genes 2019 Feb 16;55(1):51-59. Epub 2018 Nov 16.

Division of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243122, India.

Sheeppox disease is associated with significant losses in sheep production world over. The sheep pox virus, the goatpox virus, and the lumpy skin disease virus cannot be distinguished by conventional serological tests. Identification of these pathogens needs molecular methods. Read More

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http://link.springer.com/10.1007/s11262-018-1613-9
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http://dx.doi.org/10.1007/s11262-018-1613-9DOI Listing
February 2019
19 Reads

Long-term effects of smallpox vaccination on expression of the HIV-1 co-receptor CCR5 in women.

PLoS One 2018 15;13(11):e0207259. Epub 2018 Nov 15.

Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.

Background: Smallpox vaccinations were stopped globally in 1980. Recent studies have shown that in women, being smallpox vaccinated was associated with a reduced risk of HIV infection compared with not being smallpox vaccinated. At the initial infection, HIV-1 most often uses CCR5 as a co-receptor to infect the T-lymphocytes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207259PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237380PMC
April 2019
21 Reads

Seroprevalence and risk factors of lumpy skin disease in Ethiopia.

Prev Vet Med 2018 Nov 1;160:99-104. Epub 2018 Oct 1.

Quantitative Veterinary Epidemiology, Wageningen University & Research, P.O. Box 338, 6700 AH, Wageningen, the Netherlands.

Lumpy skin disease (LSD) is an acute or inapparent viral disease of cattle which is endemic in many African and Middle East countries. LSD is one of the major transboundary livestock diseases in Ethiopia. A cross-sectional study using multistage cluster sampling was undertaken in central and north-western parts of Ethiopia with the objectives to estimate seroprevalence and to identify and quantify risk factors contributing to the occurrence of the disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01675877183053
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http://dx.doi.org/10.1016/j.prevetmed.2018.09.029DOI Listing
November 2018
3 Reads

Ectromelia virus induces tubulin cytoskeletal rearrangement in immune cells accompanied by a loss of the microtubule organizing center and increased α-tubulin acetylation.

Arch Virol 2019 Feb 29;164(2):559-565. Epub 2018 Oct 29.

Division of Immunology, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, Ciszewskiego 8, 02-786, Warsaw, Poland.

Ectromelia virus (ECTV) is an orthopoxvirus that productively replicates in dendritic cells (DCs), but its influence on the microtubule (MT) cytoskeleton in DCs is not known. Here, we show that ECTV infection of primary murine granulocyte-macrophage colony stimulating factor-derived bone marrow cells (GM-BM) downregulates numerous genes engaged in MT cytoskeleton organization and dynamics. In infected cells, the MT cytoskeleton undergoes dramatic rearrangement and relaxation, accompanied by disappearance of the microtubule organizing centre (MTOC) and increased acetylation and stabilization of MTs, which are exploited by progeny virions for intracellular transport. Read More

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http://dx.doi.org/10.1007/s00705-018-4030-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373239PMC
February 2019
2 Reads

New Insights into the Evolutionary and Genomic Landscape of Molluscum Contagiosum Virus (MCV) based on Nine MCV1 and Six MCV2 Complete Genome Sequences.

Viruses 2018 10 26;10(11). Epub 2018 Oct 26.

Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, SI-1000 Ljubljana, Slovenia.

Molluscum contagiosum virus (MCV) is the sole member of the genus and the causative agent of molluscum contagiosum (MC), a common skin disease. Although it is an important and frequent human pathogen, its genetic landscape and evolutionary history remain largely unknown. In this study, ten novel complete MCV genome sequences of the two most common MCV genotypes were determined (five MCV1 and five MCV2 sequences) and analyzed together with all MCV complete genomes previously deposited in freely accessible sequence repositories (four MCV1 and a single MCV2). Read More

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http://www.mdpi.com/1999-4915/10/11/586
Publisher Site
http://dx.doi.org/10.3390/v10110586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266040PMC
October 2018
17 Reads

Molluscum contagiosum virus infection can trigger atopic dermatitis disease onset or flare.

Cutis 2018 Sep;102(3):191-194

Departments of Dermatology and Pediatrics, Mt Sinai St. Luke's of the Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Predisposition to cutaneous viral infections is known to be a minor criterion of Hanifin and Rajka's diagnostic standard of atopic dermatitis (AD); however, the causal relationship between molluscum contagiosum virus (MCV) infection and AD onset or aggravation has not been widely explored. The objective of this study was to identify pediatric patients with AD onset or flare triggered by MCV infection as well as to characterize the setting under which MCV may trigger AD onset or flares in children. Fifty children with prior or current MCV infection presenting sequentially to an outpatient pediatric dermatology practice over a 1-month period were evaluated. Read More

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September 2018
1 Read

Detection of Fowlpox virus carrying distinct genome segments of Reticuloendotheliosis virus.

Virus Res 2019 01 22;260:53-59. Epub 2018 Oct 22.

Animal Disease Research and Diagnostic Laboratory (ADRDL), Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, South Dakota, USA. Electronic address:

Fowlpox virus (FWPV), the type species of the genus Avipoxvirus family Poxviridae, is a large double-stranded DNA virus that causes fowlpox in chickens and turkeys. Notably, sequences of the avian retrovirus reticuloendotheliosis virus (REV) are frequently found integrated into the genome of FWPV. While some FWPV strains carry remnants of the REV long terminal repeats (LTRs), other strains have been shown to contain insertions of nearly the full-length REV provirus in their genome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01681702183055
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http://dx.doi.org/10.1016/j.virusres.2018.10.017DOI Listing
January 2019
14 Reads
2.324 Impact Factor

Evidence of avian poxvirus and papillomavirus infection in Gyps fulvus in Italy.

Arch Virol 2019 Jan 5;164(1):291-295. Epub 2018 Oct 5.

Faculty of Veterinary Medicine, University of Teramo, Loc. Piano D'Accio, 64100, Teramo, Italy.

The identification of avian poxvirus and avian papillomavirus associated with cutaneous lesions in griffon vultures (Gyps fulvus) by histopathology, electron microscopy and PCR analysis is reported. Sequence analysis of the fpv140 gene revealed 99% identity to two poxviruses obtained from a white-tailed sea eagle (Haliaeetus albicilla) and a common buzzard (Buteo buteo). Partial sequence of the papillomavirus L1 gene showed sequence similarity to papillomavirus LI genes from African grey parrot (Psittacus erithacus) (69% identity), duck (Anas platyrhynchos) (68% identity), and yellow-necked francolin (Francolinus leucoscepus) (66% identity). Read More

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http://link.springer.com/10.1007/s00705-018-4055-8
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http://dx.doi.org/10.1007/s00705-018-4055-8DOI Listing
January 2019
5 Reads

Horsepox: Framing a dual use research of concern debate.

Authors:
Carolyn B Coyne

PLoS Pathog 2018 10 4;14(10):e1007344. Epub 2018 Oct 4.

Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171939PMC
October 2018

Synthetic horsepox viruses and the continuing debate about dual use research.

PLoS Pathog 2018 10 4;14(10):e1007025. Epub 2018 Oct 4.

Department of Medical Microbiology & Immunology, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.plos.org/10.1371/journal.ppat.1007025
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http://dx.doi.org/10.1371/journal.ppat.1007025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171955PMC
October 2018
14 Reads

Inoculating science against potential pandemics and information hazards.

Authors:
Kevin M Esvelt

PLoS Pathog 2018 10 4;14(10):e1007286. Epub 2018 Oct 4.

MIT Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

The recent de novo assembly of horsepox is an instructive example of an information hazard: published methods enabling poxvirus synthesis led to media coverage spelling out the implications, efficiently disseminating true information that might be used to cause harm. Whether or not the benefits justified the risks, the horsepox saga provides ample reason to upgrade the current system for screening synthesized DNA for hazardous sequences, which does not cover the majority of firms and cannot reliably prevent the assembly of potentially pandemic pathogens. An upgraded system might leverage one-way encryption to confidentially scrutinize virtually all commercial production by a cooperative international network of servers whose integrity can be verified by third parties. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171951PMC
October 2018
4 Reads

Horsepox and the need for a new norm, more transparency, and stronger oversight for experiments that pose pandemic risks.

Authors:
Tom Inglesby

PLoS Pathog 2018 10 4;14(10):e1007129. Epub 2018 Oct 4.

Johns Hopkins Center for Health Security, Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171949PMC
October 2018
1 Read

Monkeypox contacts: a puzzling problem.

Authors:
The Lancet

Lancet 2018 09 20;392(10152):986. Epub 2018 Sep 20.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183225
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http://dx.doi.org/10.1016/S0140-6736(18)32254-2DOI Listing
September 2018
16 Reads

Molecular identification and microscopic characterization of poxvirus in a Guiana dolphin and a common bottlenose dolphin, Brazil.

Dis Aquat Organ 2018 09;130(3):177-185

Laboratório de Patologia Comparada de Animais Selvagens, Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP 05508-270, Brazil.

The poxviruses identified in cetaceans are associated with characteristic tattoo or ring skin lesions. However, little is known regarding the prevalence and progression of these lesions and the molecular characterization of cetacean poxviruses in the Southern Hemisphere. This manuscript describes the progression of poxvirus-like skin lesions in 5 free-ranging Guiana dolphins Sotalia guianensis. Read More

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http://dx.doi.org/10.3354/dao03271DOI Listing
September 2018
11 Reads

Eradicating TB.

BMJ 2018 Sep 25;362:k3918. Epub 2018 Sep 25.

Division of HIV, Infectious Diseases, Global Medicine, University of California, San Francisco, USA.

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http://dx.doi.org/10.1136/bmj.k3918DOI Listing
September 2018
9 Reads

Validation of a diagnostic tool for the diagnosis of lumpy skin disease.

Vet Dermatol 2018 Dec 24;29(6):532-e178. Epub 2018 Sep 24.

International Livestock Research Institute (BecA-ILRI hub), PO Box 30709, Nairobi, 00100, Kenya.

Background: Lumpy skin disease (LSD) is caused by LSD virus which is a member of the Capripoxvirus (CaPV) genus. Although PCR provides for a rapid and sensitive diagnosis, it has limited use due to its complexity in terms of cost, time and equipment. Loop-mediated isothermal amplification (LAMP) is a simple, specific and cost-effective method with a diagnostic accuracy similar to PCR. Read More

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http://dx.doi.org/10.1111/vde.12690DOI Listing
December 2018
14 Reads

Sporadic cases of lumpy skin disease among cattle in Sharkia province, Egypt: Genetic characterization of lumpy skin disease virus isolates and pathological findings.

Vet World 2018 Aug 23;11(8):1150-1158. Epub 2018 Aug 23.

Department of Virology, Faculty of Veterinary Medicine, Zagazig University, 44511-Zagazig, Sharkia Province, Egypt.

Background And Aim: Lumpy skin disease (LSD) is a highly infectious viral disease upsetting cattle, caused by LSD virus (LSDV) within the family . Sporadic cases of LSD have been observed in cattle previously vaccinated with the Romanian sheep poxvirus (SPPV) vaccine during the summer of 2016 in Sharkia province, Egypt. The present study was undertaken to perform molecular characterization of LSDV strains which circulated in this period as well as investigate their phylogenetic relatedness with published reference capripoxvirus genome sequences

Materials And Methods: A total of 82 skin nodules, as well as 5 lymph nodes, were collected from suspect LSD cases, and the virus was isolated in embryonated chicken eggs (ECEs). Read More

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http://www.veterinaryworld.org/Vol.11/August-2018/20.html
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http://dx.doi.org/10.14202/vetworld.2018.1150-1158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141277PMC
August 2018
13 Reads

Characterization of mule deerpox virus in Florida white-tailed deer fawns expands the known host and geographic range of this emerging pathogen.

Arch Virol 2019 Jan 21;164(1):51-61. Epub 2018 Sep 21.

Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Bldg 1379, Mowry Road, Gainesville, FL, 32611, USA.

Infections caused by mule deerpox virus (MDPV) have been sporadically reported in North American cervids. White-tailed deer (Odocoileus virginianus) fawns from a farm located in South Central Florida presented with ulcerative and crusting lesions on the coronary band as well as the mucocutaneous tissues of the head. Evaluation of the crusted skin lesions was undertaken using microscopic pathology and molecular techniques. Read More

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http://dx.doi.org/10.1007/s00705-018-3991-7DOI Listing
January 2019
6 Reads
2.282 Impact Factor

Respiratory infection due to direct contact with rabbit-skin powder contaminated by vaccinia virus.

Int J Infect Dis 2018 Nov 12;76:70-72. Epub 2018 Sep 12.

Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China. Electronic address:

Vaccinia virus infection was diagnosed in five male workers directly exposed to rabbit-skin powder contaminated by vaccinia virus via skin contact and inhalation. Four of the workers had been vaccinated against smallpox. Their clinical symptoms were severe, especially in the lungs; however, all symptoms improved after treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712183451
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http://dx.doi.org/10.1016/j.ijid.2018.09.005DOI Listing
November 2018
6 Reads

Identification and phylogenetic analysis of clade C Avipoxvirus in a fowlpox outbreak in exotic psittacines in southern Brazil.

J Vet Diagn Invest 2018 Nov 10;30(6):946-950. Epub 2018 Sep 10.

Departments of Preventive Veterinary Medicine (Murer, Westenhofen, Lovato), Brazil.

Fowlpox is one of the oldest diseases reported in birds. The causative genus Avipoxvirus affects ~232 domestic and wild species. We present herein the history, clinical findings, and macroscopic and histologic lesions caused by a clade C poxvirus in an exotic psittacine breeding colony in southern Brazil. Read More

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http://dx.doi.org/10.1177/1040638718775146DOI Listing
November 2018
5 Reads

The Virology of Taterapox Virus In Vitro.

Viruses 2018 08 29;10(9). Epub 2018 Aug 29.

Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St. Louis, MO 63104, USA.

Taterapox virus (TATV) is phylogenetically the closest related virus to variola-the etiological agent of smallpox. Despite the similarity, few studies have evaluated the virus. In vivo, TATV can infect several animals but produces an inapparent infection in wild-type mice; however, TATV does cause morbidity and mortality in some immunocompromised strains. Read More

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http://dx.doi.org/10.3390/v10090463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163509PMC
August 2018
20 Reads

Glycolic acid cream for treatment of molluscum contagiosum.

Dermatol Ther 2018 09 28;31(5):e12630. Epub 2018 Aug 28.

Mansoura Dermatology, Venerology and Leprology Hospital, Mansoura, Egypt.

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http://dx.doi.org/10.1111/dth.12630DOI Listing
September 2018
5 Reads

Evaluation of a recombinant major envelope protein (F1L) based indirect- ELISA for sero-diagnosis of orf in sheep and goats.

J Virol Methods 2018 11 24;261:112-120. Epub 2018 Aug 24.

ICAR- National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru, 560064, Karnataka, India.

Orf or contagious ecthyma, is a highly contagious transboundary disease of sheep and goats. For sero-diagnosis of orf, recombinant antigen based assays are considered as alternatives to conventional approaches such as serum neutralization test (SNT) and counter-immuno-electrophoresis (CIE). A major envelope protein of orf virus (ORFV), F1L, is highly immunogenic and is a candidate for use in these assays. Read More

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http://dx.doi.org/10.1016/j.jviromet.2018.08.015DOI Listing
November 2018
18 Reads
1.883 Impact Factor

Reviewing the use of imiquimod for molluscum contagiosum.

Dermatol Online J 2018 Aug 23;24(6). Epub 2018 Aug 23.

Pediatrics, Johns Hopkins Children's Center, Baltimore, Maryland.

We discuss imiquimod associated with non-application site mucosal reactions and two of our own clinical cases. In one of our patients, erosive cheilitis developed in a young boy after using topical imiquimod 5% cream for 5 nights weekly on bilateral cheeks, chin, and near vermillion border for molluscum contagiosum. The case is discussed with concerns for imiquimod use in molluscum contagiosum when used near mucosal surfaces. Read More

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August 2018
4 Reads

An outbreak of Goatpox virus infection in Wild Red Serow (Capricornis rubidus) in Mizoram, India.

Transbound Emerg Dis 2019 Jan 10;66(1):181-185. Epub 2018 Sep 10.

Department of Veterinary Microbiology, CVSc & AH, Central Agricultural University, Selesih, Aizawl, India.

Goatpox virus (GTPV) belongs to the genus Capripoxvirus associated with characteristic clinical lesions in fully susceptible breeds of sheep and goats. To date, there is no report of outbreaks of GTPV infection in any wild animals. This study reports the outbreak of GTPV infection in wild Red Serow (Capricornis rubidus. Read More

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http://doi.wiley.com/10.1111/tbed.12997
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http://dx.doi.org/10.1111/tbed.12997DOI Listing
January 2019
47 Reads

Novel Orthopoxvirus and Lethal Disease in Cat, Italy.

Emerg Infect Dis 2018 09;24(9):1665-1673

We report detection and full-genome characterization of a novel orthopoxvirus (OPXV) responsible for a fatal infection in a cat. The virus induced skin lesions histologically characterized by leukocyte infiltration and eosinophilic cytoplasmic inclusions. Different PCR approaches were unable to assign the virus to a defined OPXV species. Read More

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http://dx.doi.org/10.3201/eid2409.171283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106440PMC
September 2018
1 Read

Poxviral protein E3-altered cytokine production reveals that DExD/H-box helicase 9 controls Toll-like receptor-stimulated immune responses.

J Biol Chem 2018 09 15;293(39):14989-15001. Epub 2018 Aug 15.

From the School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

Host pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) detect viruses and other pathogens, inducing production of cytokines that cause inflammation and mobilize cells to control infection. Vaccinia virus (VACV) encodes proteins that antagonize these host innate immune responses, and elucidating the mechanisms of action of these viral proteins helped shed light on PRR signaling mechanisms. The VACV virulence factor E3 is one of the most intensely studied VACV proteins and has multiple effects on host cells, many of which cannot be explained by the currently known cellular targets of E3. Read More

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http://dx.doi.org/10.1074/jbc.RA118.005089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166711PMC
September 2018

Infectious Disease in Contact Sports.

Sports Health 2019 Jan/Feb;11(1):47-58. Epub 2018 Aug 14.

University of Minnesota, Minneapolis, Minnesota.

Context:: Infections are common in contact sports. This review aims to describe the epidemiology, presenting signs and symptoms, treatment guidelines, and regulations for several common infections seen in contact sport athletes. The conditions discussed include bacterial skin infections, herpes simplex virus, molluscum contagiosum, common warts, tinea, scabies, head lice, conjunctivitis, human immunodeficiency virus, hepatitis C virus, and vaccine-preventable illnesses. Read More

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http://dx.doi.org/10.1177/1941738118789954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299350PMC
February 2019
13 Reads

Sequence analysis of haemagglutinin gene of camelpox viruses shows deletion leading to frameshift: Circulation of diverse clusters among camelpox viruses.

Transbound Emerg Dis 2018 Dec 13;65(6):1920-1934. Epub 2018 Aug 13.

Division of Virology, ICAR-Indian Veterinary Research Institute, Mukteswar, Uttarakhand, India.

Orthopoxviruses (OPVs) have broad host range infecting a variety of species along with gene-specific determinants. Several genes including haemagglutinin (HA) are used for differentiation of OPVs. Among poxviruses, OPVs are sole members encoding HA protein as part of extracellular enveloped virion membrane. Read More

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http://dx.doi.org/10.1111/tbed.12973DOI Listing
December 2018
11 Reads
2.944 Impact Factor

The spectre of smallpox lingers.

Authors:

Nature 2018 08;560(7718):281

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http://dx.doi.org/10.1038/d41586-018-05936-xDOI Listing

A generic framework for spatial quantitative risk assessments of infectious diseases: Lumpy skin disease case study.

Transbound Emerg Dis 2019 Jan 4;66(1):131-143. Epub 2018 Sep 4.

Animal and Plant Health Agency (APHA), Weybridge, UK.

The increase in availability of spatial data and the technological advances to handle such data allow for subsequent improvements in our ability to assess risk in a spatial setting. We provide a generic framework for quantitative risk assessments of disease introduction that capitalizes on these new data. It can be adopted across multiple spatial scales, for any pathogen, method of transmission or location. Read More

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http://dx.doi.org/10.1111/tbed.12993DOI Listing
January 2019
7 Reads